AR123150A1 - Composiciones para modular el empalme - Google Patents
Composiciones para modular el empalmeInfo
- Publication number
- AR123150A1 AR123150A1 ARP210102177A ARP210102177A AR123150A1 AR 123150 A1 AR123150 A1 AR 123150A1 AR P210102177 A ARP210102177 A AR P210102177A AR P210102177 A ARP210102177 A AR P210102177A AR 123150 A1 AR123150 A1 AR 123150A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- substituted
- independently hydrogen
- independently
- halogen
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 150000003384 small molecules Chemical class 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 101100385324 Arabidopsis thaliana CRA1 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004474 heteroalkylene group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En la presente descripción se describen compuestos moduladores de empalme de molécula pequeña que modulan el empalme de ARNm, tal como el pre-ARNm, codificado por genes, y métodos de uso de los compuestos moduladores de empalme de molécula pequeña para modular el empalme y tratar enfermedades y afecciones. Reivindicación 1: Un compuesto con la fórmula (1) en donde Q es alquileno C₁₋₇ sustituido o no sustituido o heteroalquileno C₁₋₇ sustituido o no sustituido; X es hidrógeno, CH₃ o cicloalquilo C₃₋₆ sustituido o no sustituido; cada R¹ y R² es independientemente hidrógeno, halógeno, o CH₃; cada R³ y R⁴ es independientemente hidrógeno o halógeno; cada A¹, A², A³ y A⁴ es independientemente N, -NRY¹, -O-, -S-, o CRA¹; cada ⁻ ⁻ ⁻ ⁻ es independientemente un enlace simple o doble; cada RA¹ es independientemente hidrógeno, halógeno, =O, o alquilo C₁₋₆ sustituido o no sustituido; y cada RY¹ es independientemente hidrógeno o alquilo C₁₋₆ sustituido o no sustituido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063061742P | 2020-08-05 | 2020-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123150A1 true AR123150A1 (es) | 2022-11-02 |
Family
ID=80117649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102177A AR123150A1 (es) | 2020-08-05 | 2021-08-04 | Composiciones para modular el empalme |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230331718A1 (es) |
| EP (1) | EP4192454A1 (es) |
| JP (1) | JP2023538524A (es) |
| KR (1) | KR20230048106A (es) |
| CN (1) | CN116171153A (es) |
| AR (1) | AR123150A1 (es) |
| AU (1) | AU2021320763A1 (es) |
| CA (1) | CA3188104A1 (es) |
| IL (1) | IL300352A (es) |
| MX (1) | MX2023001558A (es) |
| TW (1) | TW202216697A (es) |
| UY (1) | UY39368A (es) |
| WO (1) | WO2022031838A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022521467A (ja) * | 2019-02-05 | 2022-04-08 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| KR20210135507A (ko) | 2019-02-06 | 2021-11-15 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2531492T (pt) * | 2010-02-05 | 2016-07-07 | Heptares Therapeutics Ltd | Derivados 1,2,4-triazina4-amina |
| WO2019191092A1 (en) * | 2018-03-27 | 2019-10-03 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| WO2019199972A1 (en) * | 2018-04-10 | 2019-10-17 | Skyhawk Therapeutics, Inc. | Compounds for the treatment of cancer |
| JP2022521467A (ja) * | 2019-02-05 | 2022-04-08 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| WO2020163409A1 (en) * | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
-
2021
- 2021-08-04 EP EP21852740.6A patent/EP4192454A1/en active Pending
- 2021-08-04 AR ARP210102177A patent/AR123150A1/es unknown
- 2021-08-04 JP JP2023508065A patent/JP2023538524A/ja active Pending
- 2021-08-04 AU AU2021320763A patent/AU2021320763A1/en active Pending
- 2021-08-04 UY UY0001039368A patent/UY39368A/es unknown
- 2021-08-04 WO PCT/US2021/044528 patent/WO2022031838A1/en active Application Filing
- 2021-08-04 CA CA3188104A patent/CA3188104A1/en active Pending
- 2021-08-04 IL IL300352A patent/IL300352A/en unknown
- 2021-08-04 KR KR1020237007640A patent/KR20230048106A/ko unknown
- 2021-08-04 CN CN202180062419.8A patent/CN116171153A/zh active Pending
- 2021-08-04 TW TW110128712A patent/TW202216697A/zh unknown
- 2021-08-04 MX MX2023001558A patent/MX2023001558A/es unknown
-
2023
- 2023-01-31 US US18/162,085 patent/US20230331718A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023001558A (es) | 2023-04-26 |
| UY39368A (es) | 2022-01-31 |
| IL300352A (en) | 2023-04-01 |
| AU2021320763A1 (en) | 2023-03-30 |
| CA3188104A1 (en) | 2022-02-10 |
| CN116171153A (zh) | 2023-05-26 |
| JP2023538524A (ja) | 2023-09-08 |
| EP4192454A1 (en) | 2023-06-14 |
| TW202216697A (zh) | 2022-05-01 |
| US20230331718A1 (en) | 2023-10-19 |
| KR20230048106A (ko) | 2023-04-10 |
| WO2022031838A1 (en) | 2022-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |