TW202214858A - 脫靶活性降低的修飾siRNA - Google Patents

脫靶活性降低的修飾siRNA Download PDF

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TW202214858A
TW202214858A TW110128792A TW110128792A TW202214858A TW 202214858 A TW202214858 A TW 202214858A TW 110128792 A TW110128792 A TW 110128792A TW 110128792 A TW110128792 A TW 110128792A TW 202214858 A TW202214858 A TW 202214858A
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methoxy
sirna
nucleotide
alkynyl
alkenyl
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TW110128792A
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黃金宇
羅敏
尹科
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大陸商上海拓界生物醫藥科技有限公司
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TW110128792A 2020-08-04 2021-08-04 脫靶活性降低的修飾siRNA TW202214858A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN202010772542 2020-08-04
CN202010772542.6 2020-08-04
CN202110244977 2021-03-05
CN202110244977.8 2021-03-05
CN202110361502.7 2021-04-02
CN202110361502 2021-04-02

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TW202214858A true TW202214858A (zh) 2022-04-16

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US (1) US20230287418A1 (https=)
EP (1) EP4194553A4 (https=)
JP (1) JP7849353B2 (https=)
KR (1) KR20230043195A (https=)
CN (1) CN115955973A (https=)
BR (1) BR112023002080A2 (https=)
CA (1) CA3190097A1 (https=)
TW (1) TW202214858A (https=)
WO (1) WO2022028462A1 (https=)
ZA (1) ZA202303275B (https=)

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TW202302851A (zh) * 2021-04-02 2023-01-16 大陸商上海拓界生物醫藥科技有限公司 Ｂ型肝炎病毒ｓｉＲＮＡ和ｓｉＲＮＡ綴合物
US20240229037A1 (en) * 2021-04-22 2024-07-11 Tuojie Biotech(Shanghai) Co., Ltd. SIRNA TARGETING 17Beta-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE
WO2023109932A1 (zh) * 2021-12-16 2023-06-22 上海拓界生物医药科技有限公司 一种dsRNA、其制备方法及应用
US20260076990A1 (en) 2022-01-20 2026-03-19 Tuojie Biotech (Shanghai) Co., Ltd. Dsrna, use thereof and preparation method therefor
KR20250123805A (ko) * 2022-12-13 2025-08-18 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 친유성 단량체를 포함하는 올리고뉴클레오티드 및 비-간 전달에서의 용도
JP2026503329A (ja) * 2023-02-21 2026-01-28 成都先導薬物開発股▲フン▼有限公司 ヌクレオチド類似体、その調製方法及び使用
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WO2025007907A1 (zh) * 2023-07-04 2025-01-09 大睿生物 包含肽的寡核苷酸递送配体
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CN121586578A (zh) 2023-08-24 2026-02-27 上海拓界生物医药科技有限公司 靶向RAGE的RNAi剂及其医药用途
TW202526017A (zh) * 2023-09-14 2025-07-01 美商Ionis製藥公司 用於減少ａｐｏｃｉｉｉ表現的化合物及方法
WO2025067317A1 (zh) * 2023-09-26 2025-04-03 上海拓界生物医药科技有限公司 一种脂质修饰的核酸化合物、其制备方法及用途
WO2025140299A1 (zh) * 2023-12-26 2025-07-03 广东东阳光药业股份有限公司 一种新型的化合物及其用途
WO2026002138A1 (zh) * 2024-06-27 2026-01-02 成都新泽利医药科技有限公司 特定修饰的双链寡核苷酸及其组合物
CN119410644A (zh) * 2025-01-08 2025-02-11 北京安龙生物医药有限公司 修饰的双链寡核苷酸及其缀合物和组合物
CN119528986B (zh) * 2025-01-23 2025-09-16 北京悦康科创医药科技股份有限公司 一种核苷类似物及其在降低寡核苷酸药物脱靶活性中的应用

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CN115955973A (zh) 2023-04-11
ZA202303275B (en) 2025-12-17
WO2022028462A1 (zh) 2022-02-10
JP2023536320A (ja) 2023-08-24
EP4194553A1 (en) 2023-06-14
JP7849353B2 (ja) 2026-04-21
EP4194553A4 (en) 2024-11-13
US20230287418A1 (en) 2023-09-14
CA3190097A1 (en) 2022-02-10
BR112023002080A2 (pt) 2023-04-25

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