CN115955973A - 脱靶活性降低的修饰siRNA - Google Patents

脱靶活性降低的修饰siRNA Download PDF

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CN115955973A
CN115955973A CN202180048996.1A CN202180048996A CN115955973A CN 115955973 A CN115955973 A CN 115955973A CN 202180048996 A CN202180048996 A CN 202180048996A CN 115955973 A CN115955973 A CN 115955973A
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sirna
methoxy
alkynyl
independently
compound
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黄金宇
罗敏
尹科
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Shanghai Tuojie Biomedical Technology Co ltd
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CN202180048996.1A 2020-08-04 2021-08-04 脱靶活性降低的修饰siRNA Pending CN115955973A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN202010772542 2020-08-04
CN2020107725426 2020-08-04
CN2021102449778 2021-03-05
CN202110244977 2021-03-05
CN2021103615027 2021-04-02
CN202110361502 2021-04-02
PCT/CN2021/110509 WO2022028462A1 (zh) 2020-08-04 2021-08-04 脱靶活性降低的修饰sirna

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CN115955973A true CN115955973A (zh) 2023-04-11

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US (1) US20230287418A1 (https=)
EP (1) EP4194553A4 (https=)
JP (1) JP7849353B2 (https=)
KR (1) KR20230043195A (https=)
CN (1) CN115955973A (https=)
BR (1) BR112023002080A2 (https=)
CA (1) CA3190097A1 (https=)
TW (1) TW202214858A (https=)
WO (1) WO2022028462A1 (https=)
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WO2024245410A1 (zh) * 2023-05-31 2024-12-05 上海拓界生物医药科技有限公司 一种靶向LPA的dsRNA及其应用
CN119410644A (zh) * 2025-01-08 2025-02-11 北京安龙生物医药有限公司 修饰的双链寡核苷酸及其缀合物和组合物
WO2025140299A1 (zh) * 2023-12-26 2025-07-03 广东东阳光药业股份有限公司 一种新型的化合物及其用途

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TW202302851A (zh) * 2021-04-02 2023-01-16 大陸商上海拓界生物醫藥科技有限公司 Ｂ型肝炎病毒ｓｉＲＮＡ和ｓｉＲＮＡ綴合物
CA3216332A1 (en) * 2021-04-22 2022-10-27 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting 17b-hydroxysteroid dehydrogenase type 13 and sirna conjugate
CN118339294A (zh) * 2021-12-16 2024-07-12 上海拓界生物医药科技有限公司 一种dsRNA、其制备方法及应用
TW202340469A (zh) * 2022-01-20 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其應用及製備方法
JP2025541262A (ja) * 2022-12-13 2025-12-18 上海拓界生物医薬科技有限公司 親油性モノマーを含むオリゴヌクレオチド及びその非肝臓送達における使用
WO2024175013A1 (zh) * 2023-02-21 2024-08-29 成都先导药物开发股份有限公司 核苷酸类似物及其制备方法和用途
WO2024179573A1 (zh) 2023-03-02 2024-09-06 上海拓界生物医药科技有限公司 靶向抑制素βE的siRNA、siRNA缀合物及其医药用途
EP4700125A2 (en) * 2023-04-21 2026-02-25 Suzhou Siran Biotechnology Co., Ltd. Oligomeric nucleic acid, and preparation method therefore and use thereof
CN120957994A (zh) 2023-04-27 2025-11-14 上海森辉医药有限公司 用于制备寡核苷酸类似物或其盐的中间体及其制备方法
TW202503060A (zh) 2023-06-13 2025-01-16 大陸商上海拓界生物醫藥科技有限公司 靶向ＭＭＰ７的ｓｉＲＮＡ、ｓｉＲＮＡ綴合物及其醫藥用途
WO2025007907A1 (zh) * 2023-07-04 2025-01-09 大睿生物 包含肽的寡核苷酸递送配体
AU2024315297A1 (en) 2023-08-01 2026-02-12 Tuojie Biotech (Shanghai) Co., Ltd. Dsrna targeting mapt and pharmaceutical use thereof
TW202509217A (zh) 2023-08-24 2025-03-01 大陸商上海拓界生物醫藥科技有限公司 靶向ＲＡＧＥ的ＲＮＡｉ劑及其醫藥用途
TW202526017A (zh) * 2023-09-14 2025-07-01 美商Ionis製藥公司 用於減少ａｐｏｃｉｉｉ表現的化合物及方法
AU2024351190A1 (en) * 2023-09-26 2026-03-26 Tuojie Biotech (Shanghai) Co., Ltd. Lipid-modified nucleic acid compound, and preparation method and use therefor
WO2026002138A1 (zh) * 2024-06-27 2026-01-02 成都新泽利医药科技有限公司 特定修饰的双链寡核苷酸及其组合物
CN119528986B (zh) * 2025-01-23 2025-09-16 北京悦康科创医药科技股份有限公司 一种核苷类似物及其在降低寡核苷酸药物脱靶活性中的应用

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CN111378657B (zh) * 2018-12-28 2024-03-15 苏州瑞博生物技术股份有限公司 抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111378655B (zh) * 2018-12-28 2024-03-19 苏州瑞博生物技术股份有限公司 抑制CTGF基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111378656B (zh) * 2018-12-28 2022-07-26 苏州瑞博生物技术股份有限公司 一种抑制埃博拉病毒的核酸、含有该核酸的药物组合物及其用途
CA3216332A1 (en) * 2021-04-22 2022-10-27 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting 17b-hydroxysteroid dehydrogenase type 13 and sirna conjugate

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024245410A1 (zh) * 2023-05-31 2024-12-05 上海拓界生物医药科技有限公司 一种靶向LPA的dsRNA及其应用
WO2025140299A1 (zh) * 2023-12-26 2025-07-03 广东东阳光药业股份有限公司 一种新型的化合物及其用途
CN119410644A (zh) * 2025-01-08 2025-02-11 北京安龙生物医药有限公司 修饰的双链寡核苷酸及其缀合物和组合物

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CA3190097A1 (en) 2022-02-10
JP7849353B2 (ja) 2026-04-21
KR20230043195A (ko) 2023-03-30
BR112023002080A2 (pt) 2023-04-25
WO2022028462A1 (zh) 2022-02-10
TW202214858A (zh) 2022-04-16
EP4194553A1 (en) 2023-06-14
JP2023536320A (ja) 2023-08-24
US20230287418A1 (en) 2023-09-14
ZA202303275B (en) 2025-12-17

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