CN115955973A - 脱靶活性降低的修饰siRNA - Google Patents

脱靶活性降低的修饰siRNA Download PDF

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CN115955973A
CN115955973A CN202180048996.1A CN202180048996A CN115955973A CN 115955973 A CN115955973 A CN 115955973A CN 202180048996 A CN202180048996 A CN 202180048996A CN 115955973 A CN115955973 A CN 115955973A
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sirna
methoxy
alkynyl
independently
compound
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黄金宇
罗敏
尹科
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Shanghai Tuojie Biomedical Technology Co ltd
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CN202180048996.1A 2020-08-04 2021-08-04 脱靶活性降低的修饰siRNA Pending CN115955973A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN202010772542 2020-08-04
CN2020107725426 2020-08-04
CN2021102449778 2021-03-05
CN202110244977 2021-03-05
CN202110361502 2021-04-02
CN2021103615027 2021-04-02
PCT/CN2021/110509 WO2022028462A1 (zh) 2020-08-04 2021-08-04 脱靶活性降低的修饰sirna

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US (1) US20230287418A1 (https=)
EP (1) EP4194553A4 (https=)
JP (1) JP7849353B2 (https=)
KR (1) KR20230043195A (https=)
CN (1) CN115955973A (https=)
BR (1) BR112023002080A2 (https=)
CA (1) CA3190097A1 (https=)
TW (1) TW202214858A (https=)
WO (1) WO2022028462A1 (https=)
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WO2024245410A1 (zh) * 2023-05-31 2024-12-05 上海拓界生物医药科技有限公司 一种靶向LPA的dsRNA及其应用
CN119410644A (zh) * 2025-01-08 2025-02-11 北京安龙生物医药有限公司 修饰的双链寡核苷酸及其缀合物和组合物
WO2025140299A1 (zh) * 2023-12-26 2025-07-03 广东东阳光药业股份有限公司 一种新型的化合物及其用途

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WO2019006455A1 (en) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
TW202302851A (zh) * 2021-04-02 2023-01-16 大陸商上海拓界生物醫藥科技有限公司 Ｂ型肝炎病毒ｓｉＲＮＡ和ｓｉＲＮＡ綴合物
US20240229037A1 (en) * 2021-04-22 2024-07-11 Tuojie Biotech(Shanghai) Co., Ltd. SIRNA TARGETING 17Beta-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE
WO2023109932A1 (zh) * 2021-12-16 2023-06-22 上海拓界生物医药科技有限公司 一种dsRNA、其制备方法及应用
US20260076990A1 (en) 2022-01-20 2026-03-19 Tuojie Biotech (Shanghai) Co., Ltd. Dsrna, use thereof and preparation method therefor
KR20250123805A (ko) * 2022-12-13 2025-08-18 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 친유성 단량체를 포함하는 올리고뉴클레오티드 및 비-간 전달에서의 용도
JP2026503329A (ja) * 2023-02-21 2026-01-28 成都先導薬物開発股▲フン▼有限公司 ヌクレオチド類似体、その調製方法及び使用
EP4674965A1 (en) 2023-03-02 2026-01-07 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting inhibin ?e, sirna conjugate, and medical use thereof
WO2024217152A2 (zh) * 2023-04-21 2024-10-24 苏州时安生物技术有限公司 一种寡聚核酸及其制备方法和应用
AU2024262610A1 (en) 2023-04-27 2025-10-16 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Intermediate for preparing oligonucleotide analog or salt thereof, and preparation method therefor
AU2024302964A1 (en) 2023-06-13 2025-12-18 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting mmp7, sirna conjugate and medical use thereof
WO2025007907A1 (zh) * 2023-07-04 2025-01-09 大睿生物 包含肽的寡核苷酸递送配体
AU2024315297A1 (en) 2023-08-01 2026-02-12 Tuojie Biotech (Shanghai) Co., Ltd. Dsrna targeting mapt and pharmaceutical use thereof
CN121586578A (zh) 2023-08-24 2026-02-27 上海拓界生物医药科技有限公司 靶向RAGE的RNAi剂及其医药用途
TW202526017A (zh) * 2023-09-14 2025-07-01 美商Ionis製藥公司 用於減少ａｐｏｃｉｉｉ表現的化合物及方法
WO2025067317A1 (zh) * 2023-09-26 2025-04-03 上海拓界生物医药科技有限公司 一种脂质修饰的核酸化合物、其制备方法及用途
WO2026002138A1 (zh) * 2024-06-27 2026-01-02 成都新泽利医药科技有限公司 特定修饰的双链寡核苷酸及其组合物
CN119528986B (zh) * 2025-01-23 2025-09-16 北京悦康科创医药科技股份有限公司 一种核苷类似物及其在降低寡核苷酸药物脱靶活性中的应用

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CN111378657B (zh) * 2018-12-28 2024-03-15 苏州瑞博生物技术股份有限公司 抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111378656B (zh) * 2018-12-28 2022-07-26 苏州瑞博生物技术股份有限公司 一种抑制埃博拉病毒的核酸、含有该核酸的药物组合物及其用途
US20240229037A1 (en) * 2021-04-22 2024-07-11 Tuojie Biotech(Shanghai) Co., Ltd. SIRNA TARGETING 17Beta-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE

Cited By (3)

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Publication number Priority date Publication date Assignee Title
WO2024245410A1 (zh) * 2023-05-31 2024-12-05 上海拓界生物医药科技有限公司 一种靶向LPA的dsRNA及其应用
WO2025140299A1 (zh) * 2023-12-26 2025-07-03 广东东阳光药业股份有限公司 一种新型的化合物及其用途
CN119410644A (zh) * 2025-01-08 2025-02-11 北京安龙生物医药有限公司 修饰的双链寡核苷酸及其缀合物和组合物

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ZA202303275B (en) 2025-12-17
WO2022028462A1 (zh) 2022-02-10
JP2023536320A (ja) 2023-08-24
EP4194553A1 (en) 2023-06-14
JP7849353B2 (ja) 2026-04-21
EP4194553A4 (en) 2024-11-13
US20230287418A1 (en) 2023-09-14
CA3190097A1 (en) 2022-02-10
BR112023002080A2 (pt) 2023-04-25

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