CN115955973A - 脱靶活性降低的修饰siRNA - Google Patents

脱靶活性降低的修饰siRNA Download PDF

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CN115955973A
CN115955973A CN202180048996.1A CN202180048996A CN115955973A CN 115955973 A CN115955973 A CN 115955973A CN 202180048996 A CN202180048996 A CN 202180048996A CN 115955973 A CN115955973 A CN 115955973A
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sirna
methoxy
alkynyl
independently
compound
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黄金宇
罗敏
尹科
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Shanghai Tuojie Biomedical Technology Co ltd
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Abstract

脱靶活性降低的修饰siRNA。一种siRNA，其包含有义链和反义链，其中反义链在其5’区域的第2位至第8位中的至少一个核苷酸位置处包含式(I)所示的化学修饰或其互变异构体修饰。包含该siRNA的缀合物、药物组合物、细胞或试剂盒，以及该siRNA、其缀合物和/或药物组合物的医药用途。式(II)和式(III)所示的化合物或其互变异构体及其制备方法。

Description

PCT国内申请，说明书已公开。

Claims (33)

  1. PCT国内申请，权利要求书已公开。
CN202180048996.1A 2020-08-04 2021-08-04 脱靶活性降低的修饰siRNA Pending CN115955973A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2020107725426 2020-08-04
CN202010772542 2020-08-04
CN2021102449778 2021-03-05
CN202110244977 2021-03-05
CN2021103615027 2021-04-02
CN202110361502 2021-04-02
PCT/CN2021/110509 WO2022028462A1 (zh) 2020-08-04 2021-08-04 脱靶活性降低的修饰sirna

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CN115955973A true CN115955973A (zh) 2023-04-11

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US (1) US20230287418A1 (zh)
EP (1) EP4194553A1 (zh)
JP (1) JP2023536320A (zh)
KR (1) KR20230043195A (zh)
CN (1) CN115955973A (zh)
BR (1) BR112023002080A2 (zh)
CA (1) CA3190097A1 (zh)
TW (1) TW202214858A (zh)
WO (1) WO2022028462A1 (zh)

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TW202302851A (zh) * 2021-04-02 2023-01-16 大陸商上海拓界生物醫藥科技有限公司 Ｂ型肝炎病毒ｓｉＲＮＡ和ｓｉＲＮＡ綴合物
TW202334424A (zh) * 2021-12-16 2023-09-01 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其製備方法及應用
TW202340469A (zh) * 2022-01-20 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其應用及製備方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009102427A2 (en) * 2008-02-11 2009-08-20 Rxi Pharmaceuticals Corp. Modified rnai polynucleotides and uses thereof
ES2947520T3 (es) 2012-08-06 2023-08-10 Alnylam Pharmaceuticals Inc Proceso para la preparación de agentes de ARN conjugados con carbohidratos
KR20180086260A (ko) * 2015-12-13 2018-07-30 닛토덴코 가부시키가이샤 높은 활성 및 감소한 오프 타겟을 위한 sirna 구조
CN107177597B (zh) * 2016-08-18 2019-12-27 广州市锐博生物科技有限公司 用于抑制P65靶基因mRNA表达的寡核酸分子及其成套组合物
CN111378657B (zh) * 2018-12-28 2024-03-15 苏州瑞博生物技术股份有限公司 抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111378655B (zh) * 2018-12-28 2024-03-19 苏州瑞博生物技术股份有限公司 抑制CTGF基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111378656B (zh) * 2018-12-28 2022-07-26 苏州瑞博生物技术股份有限公司 一种抑制埃博拉病毒的核酸、含有该核酸的药物组合物及其用途

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KR20230043195A (ko) 2023-03-30
EP4194553A1 (en) 2023-06-14
BR112023002080A2 (pt) 2023-04-25
JP2023536320A (ja) 2023-08-24
CA3190097A1 (en) 2022-02-10
WO2022028462A1 (zh) 2022-02-10
US20230287418A1 (en) 2023-09-14
TW202214858A (zh) 2022-04-16

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