KR20230043195A - 오프-타겟 활성이 감소된 변형된 siRNA - Google Patents

오프-타겟 활성이 감소된 변형된 siRNA Download PDF

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KR20230043195A
KR20230043195A KR1020237006847A KR20237006847A KR20230043195A KR 20230043195 A KR20230043195 A KR 20230043195A KR 1020237006847 A KR1020237006847 A KR 1020237006847A KR 20237006847 A KR20237006847 A KR 20237006847A KR 20230043195 A KR20230043195 A KR 20230043195A
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methoxy
alkyl
alkynyl
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진유 황
민 루오
케 인
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투오지에 바이오텍 (상하이) 컴퍼니 리미티드
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KR1020237006847A 2020-08-04 2021-08-04 오프-타겟 활성이 감소된 변형된 siRNA Pending KR20230043195A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN202010772542.6 2020-08-04
CN202010772542 2020-08-04
CN202110244977.8 2021-03-05
CN202110244977 2021-03-05
CN202110361502.7 2021-04-02
CN202110361502 2021-04-02
PCT/CN2021/110509 WO2022028462A1 (zh) 2020-08-04 2021-08-04 脱靶活性降低的修饰sirna

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US (1) US20230287418A1 (https=)
EP (1) EP4194553A4 (https=)
JP (1) JP7849353B2 (https=)
KR (1) KR20230043195A (https=)
CN (1) CN115955973A (https=)
BR (1) BR112023002080A2 (https=)
CA (1) CA3190097A1 (https=)
TW (1) TW202214858A (https=)
WO (1) WO2022028462A1 (https=)
ZA (1) ZA202303275B (https=)

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TW202526017A (zh) * 2023-09-14 2025-07-01 美商Ionis製藥公司 用於減少ａｐｏｃｉｉｉ表現的化合物及方法
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WO2022028462A1 (zh) 2022-02-10
CN115955973A (zh) 2023-04-11
TW202214858A (zh) 2022-04-16
EP4194553A1 (en) 2023-06-14
JP2023536320A (ja) 2023-08-24
US20230287418A1 (en) 2023-09-14
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