TW202126651A - 吡啶酮化合物及使用方法 - Google Patents

吡啶酮化合物及使用方法 Download PDF

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Publication number
TW202126651A
TW202126651A TW109133416A TW109133416A TW202126651A TW 202126651 A TW202126651 A TW 202126651A TW 109133416 A TW109133416 A TW 109133416A TW 109133416 A TW109133416 A TW 109133416A TW 202126651 A TW202126651 A TW 202126651A
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TW
Taiwan
Prior art keywords
membered
alkyl
group
fluorophenyl
alkylene
Prior art date
Application number
TW109133416A
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English (en)
Chinese (zh)
Inventor
林 班儂
米娜 布依
發明 蔣
傑克 馬恩
安德魯 勞布
賈斯汀 桑文特
班傑明 斯潘格勒
健雲 曹
王勇
維 許
Original Assignee
美商艾克塞里克斯公司
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Application filed by 美商艾克塞里克斯公司 filed Critical 美商艾克塞里克斯公司
Publication of TW202126651A publication Critical patent/TW202126651A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW109133416A 2019-09-26 2020-09-25 吡啶酮化合物及使用方法 TW202126651A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962906647P 2019-09-26 2019-09-26
US62/906,647 2019-09-26
US202063053530P 2020-07-17 2020-07-17
US63/053,530 2020-07-17

Publications (1)

Publication Number Publication Date
TW202126651A true TW202126651A (zh) 2021-07-16

Family

ID=72827019

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109133416A TW202126651A (zh) 2019-09-26 2020-09-25 吡啶酮化合物及使用方法

Country Status (8)

Country Link
US (1) US12371428B2 (enExample)
EP (1) EP4034532A1 (enExample)
JP (1) JP2022551422A (enExample)
CN (1) CN114787144A (enExample)
AU (1) AU2020351782A1 (enExample)
CA (1) CA3155924A1 (enExample)
TW (1) TW202126651A (enExample)
WO (1) WO2021062245A1 (enExample)

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WO2025096463A1 (en) * 2023-10-30 2025-05-08 Vibliome Therapeutics, Llc Plk4 modulators
CN118878515B (zh) * 2024-06-19 2025-10-28 河北科技大学 一种取代苯胺嘧啶类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
EP4034532A1 (en) 2022-08-03
US12371428B2 (en) 2025-07-29
CN114787144A (zh) 2022-07-22
AU2020351782A1 (en) 2022-04-21
WO2021062245A1 (en) 2021-04-01
US20220315579A1 (en) 2022-10-06
JP2022551422A (ja) 2022-12-09
CA3155924A1 (en) 2021-04-01

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