TW202039444A - 作為殺真菌化合物之嗒(硫)醯胺 - Google Patents

作為殺真菌化合物之嗒(硫)醯胺 Download PDF

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TW202039444A
TW202039444A TW108143210A TW108143210A TW202039444A TW 202039444 A TW202039444 A TW 202039444A TW 108143210 A TW108143210 A TW 108143210A TW 108143210 A TW108143210 A TW 108143210A TW 202039444 A TW202039444 A TW 202039444A
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group
membered
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alkoxy
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瀟 陳
皮爾 克里斯陶
傑瑞米 杜芙
賽依德 馬森 依絲
茱莉 蓋斯特
瑪蒂爾 葛吉斯
多明尼克 洛克
安東尼 米列
丹尼爾 瑞克
安 索菲 賀伯史塔克
菲力浦 瑞諾斐
佐藤善孝
亞力山德 蘇道
文森 湯瑪士
斐勒麗 托慶
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德商拜耳廠股份有限公司
德商拜耳作物科學公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

本發明係關於嗒𠯤(硫)醯胺化合物、其製備方法及中間物以及其用於控制植物病原性微生物，諸如植物病原性真菌之用途。

Description

作為殺真菌化合物之嗒𠯤(硫)醯胺
本發明係關於嗒𠯤(硫)醯胺化合物及其用於控制植物病原性微生物(諸如植物病原性真菌)之用途。其亦關於用於製備此等化合物之方法及中間物。
迄今為止已研發出大量作物保護劑以對抗或預防微生物之傳染。然而，仍需要研發新化合物，如此，以便提供有效對抗具有低毒性、較高選擇性或可以低施用率使用同時仍允許有效有害生物防治的廣效性植物病原性微生物(諸如真菌)之化合物。亦期望可具有預防抗性出現之新穎化合物。
本發明提供用於控制諸如真菌之植物病原性微生物的新穎化合物，該等新穎化合物具有在至少一些此等方面優於已知化合物及組合物的優勢。
本發明係關於式(I)之化合物：
Figure 02_image003
， 其中T 、n 、m 、R1 、 R2 、R3 、R4 、R5 、R6 、R7 、R8 及Q 如本文所敍述；以及其鹽、N-氧化物及溶劑合物。
本發明係關於一種組合物，其包含至少一種如本文所定義之式(I)之化合物及至少一種農業上適合之助劑。
本發明係關於一種控制植物病原性真菌之方法，該方法包含以下步驟：將至少一種如本文所定義之式(I)之化合物或如本文所定義之組合物施加至植物、植物部分、種子、果實或施加至植物生長之土壤中。
本發明亦關於用於製備式(I)之化合物之方法及中間物。
定義 如本文所使用之術語「鹵素」係指氟、氯、溴或碘原子。
如本文中所使用之術語「亞甲基」係指經由雙鍵連接至碳原子之CH2 基團。
如本文所使用之術語「鹵亞甲基」係指經由雙鍵連接至碳原子之CX2 基團，其中X為鹵素。
如本文所使用之術語「側氧基」係指經由雙鍵鍵結至碳原子或硫原子之氧原子。
如本文所使用之術語「C1 -C6 烷基」係指具有1、2、3、4、5或6個碳原子之飽和的分支鏈或直鏈烴鏈。C1 -C6 烷基之實例包括但不限於甲基、乙基、丙基(正丙基)、1-甲基乙基(異丙基)、丁基(正丁基)、1-甲基丙基(第二丁基)、2-甲基丙基(異丁基)、1,1-二甲基乙基(第三丁基)、戊基、1-甲基丁基、2-甲基丁基、3-甲基丁基、2,2-二甲基丙基、1-乙基丙基、1,1-二甲基丙基、1,2-二甲基丙基、己基、1-甲基戊基、2-甲基戊基、3-甲基戊基、4-甲基戊基、1,1-二甲基丁基、1,2-二甲基丁基、1,3-二甲基丁基、2,2-二甲基丁基、2,3-二甲基丁基、3,3-二甲基丁基、1-乙基丁基、2-乙基丁基、1,1,2-三甲基丙基、1,2,2-三甲基丙基、1-乙基-1-甲基丙基及1-乙基-2-甲基丙基。特定言之，該烴鏈具有1、2、3或4個碳原子(「C1 -C4 烷基」)，例如甲基、乙基、丙基、異丙基、丁基、第二丁基、異丁基或第三丁基。
如本文所使用之術語「C2 -C6 烯基」係指具有2、3、4、5或6個碳原子且包含至少一個雙鍵之不飽和的分支鏈或直鏈烴鏈。C2 -C6 烯基之實例包括但不限於乙烯基(或「乙烯基(vinyl)」)、丙-2-烯-1-基(或「烯丙基」)、丙-1-烯-1-基、丁-3-烯基、丁-2-烯基、丁-1-烯基、戊-4-烯基、戊-3-烯基、戊-2-烯基、戊-1-烯基、己-5-烯基、己-4-烯基、己-3-烯基、己-2-烯基、己-1-烯基、丙-1-烯-2-基(或「異丙烯基」)、2-甲基丙-2-烯基、1-甲基丙-2-烯基、2-甲基丙-1-烯基、1-甲基丙-1-烯基、3-甲基丁-3-烯基、2-甲基丁-3-烯基、1-甲基丁-3-烯基、3-甲基丁-2-烯基、2-甲基丁-2-烯基、1-甲基丁-2-烯基、3-甲基丁-1-烯基、2-甲基丁-1-烯基、1-甲基丁-1-烯基、1,1-二甲基丙-2-烯基、1-乙基丙-1-烯基、1-丙基乙烯基，1-異丙基乙烯基、4-甲基戊-4-烯基、3-甲基戊-4-烯基、2-甲基戊-4-烯基、1-甲基戊-4-烯基、4-甲基戊-3-烯基、3-甲基戊-3-烯基、2-甲基戊-3-烯基、1-甲基戊-3-烯基、4-甲基戊-2-烯基、3-甲基戊-2-烯基、2-甲基戊-2-烯基、1-甲基戊-2-烯基、4-甲基戊-1-烯基、3-甲基戊-1-烯基、2-甲基戊-1-烯基、1-甲基戊-1-烯基、3-乙基丁-3-烯基、2-乙基丁-3-烯基、1-乙基丁-3-烯基、3-乙基丁-2-烯基、2-乙基丁-2-烯基、1-乙基丁-2-烯基、3-乙基丁-1-烯基、2-乙基丁-1-烯基、1-乙基丁-1-烯基、2-丙基丙-2-烯基、1-丙基丙-2-烯基、2-異丙基丙-2-烯基、1-異丙基丙-2-烯基、2-丙基丙-1-烯基、1-丙基丙-1-烯基、2-異丙基丙-1-烯基、1-異丙基丙-1-烯基、3,3-二甲基丙-1-烯基、1-(1,1-二甲基乙基)乙烯基、丁-1,3-二烯基，戊-1,4-二烯基、己-1,5-二烯基或甲基己二烯基。
如本文所使用之術語「C2 -C6 炔基」係指具有2、3、4、5或6個碳原子且包含至少一個參鍵之分支鏈或直鏈烴鏈。C2 -C6 炔基之實例包括但不限於乙炔基、丙-1-炔基、丙-2-炔基(或「炔丙基」)、丁-1-炔基、丁-2-炔基、丁-3-炔基、戊-1-炔基、戊-2-炔基、戊-3-炔基、戊-4-炔基、己-1炔基、己-2-炔基、己-3-炔基、己-4-炔基、己-5-炔基、1-甲基丙-2-炔基、2-甲基丁-3-炔基、1-甲基丁-3-炔基、1-甲基丁-2-炔基、3-甲基丁-1-炔基、1-乙基丙-2-炔基、3-甲基戊-4-炔基、2-甲基戊-4-炔基、1-甲基-戊-4-炔基、2-甲基戊-3-炔基、1-甲基戊-3-炔基、4-甲基戊-2-炔基、1-甲基-戊-2-炔基、4-甲基戊-1-炔基、3-甲基戊-1-炔基、2-乙基丁-3-炔基、1-乙基丁-3-炔基、1-乙基丁-2-炔基、1-丙基丙-2-炔基、1-異丙基丙-2-炔基、2,2-二甲基丁-3-炔基、1,1-二甲基丁-3-炔基、1,1-二甲基丁-2-炔基或3,3-二甲基丁-1-炔基。
如本文所使用之術語「C1 -C6 鹵烷基」係指如上文所定義之C1 -C6 烷基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C2 -C6 鹵烯基」係指如上文所定義之C2 -C6 烯基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C2 -C6 鹵炔基」係指如上文所定義之C2 -C6 炔基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C1 -C6 烷氧基」係指式(C1 -C6 烷基)-O-之基團，其中術語「C1 -C6 烷基」如本文中所定義。C1 -C6 烷氧基之實例包括但不限於甲氧基、乙氧基、正丙氧基、1-甲基乙氧基、正丁氧基、1-甲基丙氧基、2-甲基丙氧基、1,1-二甲基乙氧基、正戊氧基、1-甲基丁氧基、2-甲基丁氧基、3-甲基丁氧基、2,2-二甲基丙氧基、1-乙基丙氧基、1,1-二甲基丙氧基、1,2-二甲基丙氧基、正己氧基、1-甲基戊氧基、2-甲基戊氧基、3-甲基戊氧基、4-甲基戊氧基、1,1-二甲基丁氧基、1,2-二甲基丁氧基、1,3-二甲基丁氧基、2,2-二甲基丁氧基、2,3-二甲基丁氧基、3,3-二甲基丁氧基、1-乙基丁氧基、2-乙基丁氧基、1,1,2-三甲基丙氧基、1,2,2-三甲基丙氧基、1-乙基-1-甲基丙氧基及1-乙基-2-甲基丙氧基。
如本文所使用之術語「C1 -C6 鹵烷氧基」係指如上文所定義之C1 -C6 烷氧基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。C1 -C6 鹵烷氧基之實例包括但不限於氯甲氧基、溴甲氧基、二氯甲氧基、三氯甲氧基、氟甲氧基、二氟甲氧基、三氟甲氧基、氯氟甲氧基、二氯氟甲氧基、氯二氟甲氧基、1-氯乙氧基、1-溴乙氧基、1-氟乙氧基、2-氟乙氧基、2,2-二氟乙氧基、2,2,2-三氟乙氧基、2-氯-2-氟乙氧基、2-氯-2,2-二氟乙氧基、2,2-二氯-2-氟乙氧基、2,2,2-三氯乙氧基、五氟乙氧基及1,1,1-三氟丙-2-氧基。
如本文所使用之術語「C1 -C6 鹵烷氧基」係指如上文所定義之C1 -C6 烷氧基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C1 -C6 羥基烷基」係指如上文所定義之C1 -C6 烷基，其中至少一個氫原子經羥基置換。C1 -C6 羥基烷基之實例包括但不限於羥基甲基、1-羥基乙基、2-羥基乙基、1,2-二羥基乙基、3-羥基丙基、2-羥基丙基、1-羥基丙基、1-羥基丙-2-基、2-羥基丙-2-基、2,3-二羥丙基及1,3-二羥基丙-2-基。
如本文所使用之術語「C1 -C6 烷基硫基」係指式(C1 -C6 烷基)-S-之飽和的直鏈或分支鏈基團，其中術語「C1 -C6 烷基」如本文中所定義。C1 -C6 烷基硫基之實例包括但不限於甲基硫基、乙基硫基、丙基硫基、異丙基硫基、丁基硫基、第二丁基硫基、異丁基硫基、第三丁基硫基、戊基硫基、異戊基硫基、己基硫基。
如本文所使用之術語「C1 -C6 鹵烷基硫基」係指如上文所定義之C1 -C6 烷基硫基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C1 -C6 烷基亞磺醯基」係指式(C1 -C6 烷基)-S(=O)-之飽和的直鏈或分支鏈基團，其中術語「C1 -C6 烷基」如本文中所定義。C1 -C6 烷基亞磺醯基之實例包括但不限於具有1至8個、較佳1至6個且更佳1至4個碳原子之飽和的直鏈或分支鏈烷基亞磺醯基，例如(但不限於) C1 -C6 亞磺醯基，諸如甲基亞磺醯基、乙基亞磺醯基、丙基亞磺醯基、1-甲基乙基亞磺醯基、丁基亞磺醯基、1-甲基丙基亞磺醯基、2-甲基丙基亞磺醯基、1,1-二甲基乙基亞磺醯基、戊基亞磺醯基、1-甲基丁基亞磺醯基、2-甲基丁基亞磺醯基、3-甲基丁基亞磺醯基、2,2-二甲基丙基亞磺醯基、1-乙基丙基亞磺醯基、1,1-二甲基丙基亞磺醯基、1,2-二甲基丙基亞磺醯基、己基亞磺醯基、1-甲基戊基亞磺醯基、2-甲基戊基亞磺醯基、3-甲基戊基亞磺醯基、4-甲基戊基亞磺醯基、1,1-二甲基丁基亞磺醯基、1,2-二甲基丁基亞磺醯基、1,3-二甲基丁基亞磺醯基、2,2-二甲基丁基亞磺醯基、2,3-二甲基丁基亞磺醯基、3,3-二甲基丁基亞磺醯基、1-乙基丁基亞磺醯基、2-乙基丁基亞磺醯基、1,1,2-三甲基丙基亞磺醯基、1,2,2-三甲基丙基亞磺醯基、1-乙基-1-甲基丙基亞磺醯基及1-乙基-2-甲基丙基亞磺醯基。
如本文所使用之術語「C1 -C6 鹵烷基亞磺醯基」係指如上文所定義之C1 -C6 烷基亞磺醯基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C1 -C6 烷基磺醯基」係指式(C1 -C6 烷基)-S(=O)2 -之飽和的直鏈或分支鏈基團，其中術語「C1 -C6 烷基」如本文中所定義。C1 -C6 烷基磺醯基之實例包括但不限於甲磺醯基、乙磺醯基、丙磺醯基、1-甲基乙基磺醯基、丁磺醯基、1-甲基丙基磺醯基、2-甲基丙基磺醯基、1,1-二甲基乙磺醯基、戊基磺醯基、1-甲基丁基磺醯基、2-甲基丁基磺醯基、3-甲基丁基磺醯基、2,2-二甲基丙基磺醯基、1-乙基丙基磺醯基、1,1-二甲基丙基磺醯基、1,2-二甲基丙基磺醯基、己磺醯基、1-甲基戊基磺醯基、2-甲基戊基磺醯基、3-甲基戊基磺醯基、4-甲基戊基磺醯基、1,1-二甲基丁基磺醯基、1,2-二甲基丁基磺醯基、1,3-二甲基丁基磺醯基、2,2-二甲基丁基磺醯基、2,3-二甲基丁基磺醯基、3,3-二甲基丁基磺醯基、1-乙基丁基磺醯基、2-乙基丁基磺醯基、1,1,2-三甲基丙基磺醯基、1,2,2-三甲基丙基磺醯基、1-乙基-1-甲基丙基磺醯基及1-乙基-2-甲基丙基磺醯基。
如本文所使用之術語「C1 -C6 鹵烷基磺醯基」係指如上文所定義之C1 -C6 烷基磺醯基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C1 -C6 烷基羰基」係指式(C1 -C6 烷基)-C(=O)-之飽和的直鏈或分支鏈基團，其中術語「C1 -C6 烷基」如本文中所定義。
如本文所使用之術語「C1 -C6 鹵烷基羰基」係指如上文所定義之C1 -C6 烷基羰基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C1 -C6 烷氧羰基」係指式(C1 -C6 烷氧基)-C(=O)-之飽和的直鏈或分支鏈基團，其中術語「C1 -C6 烷氧基」如本文所定義。
如本文所使用之術語「C1 -C6 鹵烷氧羰基」係指如上文所定義之C1 -C6 烷氧羰基，其中一或多個氫原子經一或多個可相同或不同之鹵素原子置換。
如本文所使用之術語「C1 -C6 二烷基胺基」係指具有兩個獨立選擇的如本文所定義之C1 -C6 烷基的胺基。C1 -C6 二烷基胺基之實例包括但不限於N , N - 二甲胺基、N , N -二乙胺基、N , N -二異丙胺基、N -乙基-N -甲胺基、N -甲基-N -正丙胺基、N -異丙基-N -正丙胺基及N -第三丁基-N -甲胺基。
如本文所使用之術語「非芳族C3 -C12 碳環」係指非芳族、飽和或不飽和烴環系統，其中所有環成員(其在3至12之間變化)均為碳原子。環系統可為單環或多環(稠合、螺接或橋接)。非芳族C3 -C12 碳環包括但不限於C3 -C12 環烷基(單或雙環)、C3 -C12 環烯基(單或雙環)、包含與單環C3 -C8 環烷基(例如四氫萘基、二氫茚基)稠合之芳基(例如苯基)的雙環系統、包含與單環C3 -C8 環烯基(例如茚基、二氫萘基)稠合之芳基(例如苯基)的雙環系統及包含經由一個碳原子將環丙基連接至雙環系統的三環系統，該雙環系統包含與單環C3 -C8 環烷基或C3 -C8 環烯基稠合之芳基(例如苯基)。非芳族C3 -C12 碳環可經由任何碳原子連接至母體分子部分。
如本文所使用之術語「C3 -C12 環烷基」係指含有3、4、5、6、7、8、9、10、11或12個碳原子之飽和的單價的單環或雙環烴環。單環C3 -C8 環烷基之實例包括但不限於環丙基、環丁基、環戊基、環己基、環庚基或環辛基。雙環C6 -C12 環烷基之實例包括但不限於雙環[3.1.1]庚烷、雙環[2.2.1]庚烷、雙環[2.2.2]辛烷、雙環[3.2.2]壬烷、雙環[3.3.1]壬烷、雙環[4.2.0]辛基、八氫并環戊二烯基及雙環[4.2.1]壬烷。
如本文所使用之術語「C3 -C12 環烯基」係指含有3、4、5、6、7、8、9、10、11或12個碳原子之飽和的單價的單環或雙環烴環。單環C3 -C8 環烯基之實例包括但不限於環丁烯基、環戊烯基、環己烯基、環庚烯基及環辛烯基。雙環C6 -C12 環烯基之實例包括但不限於雙環[2.2.1]庚-2-烯基或雙環[2.2.2]辛-2-烯基。
如本文所使用之術語「芳族C6 -C14 碳環」或「芳基」係指芳族烴環系統，其中所有環成員(其在6至14、較佳6至10之間變化)均為碳原子。環系統可為單環或稠合多環(例如，雙環或三環)。芳基之實例包括但不限於苯基、薁基及萘基。芳基可經由任何碳原子連接至母體分子部分。此外應瞭解，當該芳基經一或多個取代基取代時，該(等)取代基可處於該(等)芳環上之任何位置。特定言之，在芳基為苯基之情況下，該(等)取代基可佔據一個或兩個鄰位、一個或兩個間位或對位或此等位置之任何組合。
如本文所使用之術語「非芳族3員至14員雜環」係指包含1至4個雜原子之飽和或不飽和非芳族環系統，該等雜原子獨立地選自由氧、氮及硫組成之群。若環系統含有超過一個氧原子，則其不直接相鄰。非芳族雜環包括但不限於3至7員單環非芳族雜環及6至14員多環(例如雙環或三環)非芳族雜環。非芳族3員至14員雜環可經由雜環內所含有之任何碳原子或氮原子連接至母分子部分。
如本文所使用之術語「非芳族3員至7員單環雜環」係指含有1、2或3個選自由氧、氮及硫組成之群之雜原子的3員、4員、5員、6員或7員單環系統，其中環系統為飽和或不飽和的但不為芳族的。舉例而言，雜環可包含一至三個氮原子、或一或兩個氧原子、或一或兩個硫原子、或一至三個氮原子及一個氧原子、或一至三個氮原子及一個硫原子、或一個硫原子及一個氧原子。飽和非芳族雜環之實例包括但不限於3員環(諸如環氧乙烷基、氮丙啶基)、4員環(諸如氮雜環丁烷基、氧雜環丁烷基、硫雜環丁烷基)、5員環(諸如四氫呋喃基、1,3-二氧戊環基、四氫噻吩基、吡咯啶基、吡唑啶基、咪唑啶基、三唑啶基、異噁唑啶基、噁唑啶基、噁二唑啶基、噻唑啶基、異噻唑啶基、噻二唑啶基)、6員環(諸如哌啶基、六氫嗒𠯤基、六氫嘧啶基、哌𠯤基、三氮雜環己烷基、六氫三嗪基、四氫哌喃基、二噁烷基、四氫硫代哌喃基、二噻烷基、嗎啉基、1,2-氧氮雜環己烷基、氧硫雜環己烷基、硫代嗎啉基)或7員環(諸如氧雜環庚烷基、氮雜環庚烷基、1,4-二氮雜環庚烷基及1,4-氧氮雜環庚烷基)。不飽和非芳族雜環基之實例包括但不限於5員環，諸如二氫呋喃基、1,3-間二氧雜環戊烯基、二氫噻吩基、吡咯啉基、二氫咪唑基、二氫吡唑基、異噁唑啉基、二氫噁唑基、二氫噻唑基或6員環，諸如哌喃基、硫代哌喃基、噻嗪基及噻二嗪基。
如本文所使用之術語「非芳族6員至14員多環雜環」係指含有1、2或3個獨立地選自由氧、氮及硫組成之群之雜原子的6員、7員、8員、9員、10員、11員、12員、13員或14員多環(例如雙環或三環)環系統，其中環系統為飽和或不飽和的但不為芳族的。非芳族雙環雜環可由如本文中所定義之與單環C3 -C8 環烷基、單環C3 -C8 環烯基或單環非芳族雜環稠合之單環雜芳基組成，或可由與芳基(例如苯基)、單環C3 -C8 環烷基、單環C3 -C8 環烯基或單環非芳族雜環稠合之單環非芳族雜環組成。當包含氮原子之兩個單環雜環(芳族或非芳族)稠合時，氮原子可在橋頭處(例如4,5,6,7-四氫吡唑并[1,5-a]吡啶基、5,6,7,8-四氫-[1,2,4]三唑并[1,5-a]吡啶基、5,6,7,8-四氫咪唑并[1,2-a]吡啶基)。非芳族三環雜環可由經由一個共同原子連接至非芳族雙環雜環之單環環烷基組成。
如本文所使用之術語「芳族5員至14員雜環」或「雜芳基」係指包含1至4個雜原子之芳環系統，該等雜原子獨立地選自由氧、氮及硫組成之群。若環系統含有超過一個氧原子，則其不直接相鄰。芳族雜環包括芳族5員或6員單環雜環及6員至14員多環(例如雙環或三環)芳族雜環。5員至14員芳族雜環可經由雜環內所含有之任何碳原子或氮原子連接至母體分子部分。
如本文所使用之術語「芳族5員或6員單環雜環」或「單環雜芳基」係指含有1、2、3或4個獨立地選自由氧、氮及硫組成之群之雜原子的5員或6員單環系統。5員單環雜芳基之實例包括但不限於呋喃基(呋喃基(furanyl))、噻吩基、吡咯基、吡唑基、咪唑基、三唑基、四唑基、異噁唑基、噁唑基、噁二唑基、噁三唑基、異噻唑基、噻唑基、噻二唑基及噻三唑基。6員單環雜芳基之實例包括但不限於吡啶基、噠𠯤基、嘧啶基、吡嗪基、三嗪基、四嗪基。
如本文所使用之術語「6員至14員多環芳族雜環」或「多環雜芳基」係指含有1、2或3個獨立地選自由氧、氮及硫組成之群之雜原子的6員、7員、8員、9員、10員、11員、12員、13員或14員多環(例如雙環或三環)環系統。芳族雙環雜環可由如本文所定義之與芳基(例如苯基)或與單環雜芳基稠合的單環雜芳基組成。雙環芳族雜環之實例包括但不限於9員環，諸如吲哚基、吲哚嗪基、異吲哚基、苯并吡唑基、咪唑并吡啶基、吲唑基、苯并三唑基、嘌呤基、苯并呋喃基、苯并噻吩基、苯并噻唑基、苯并噁唑基及苯并異噁唑基或10員環，諸如喹啉基、異喹啉基、㖕啉基、喹唑啉基、喹喏啉基、酞嗪基、㖠啶基、喋啶基及苯并二氧雜環己烯基。在包含兩個稠合5員或6員單環芳族雜環之9員或10員芳族雙環雜環中，氮原子可在橋頭處(例如，咪唑并[1,2-a]吡啶基、[1,2,4]三唑并[4,3-a]吡啶基、咪唑并[1,2-a]吡啶基、咪唑并[2,1-b]噁唑基、呋喃并[2,3-d]異噁唑基)。三環芳族雜環之實例包括但不限於咔唑基、吖啶基及啡嗪基。
如本文所使用之術語「非芳族C3 -C12 碳環基氧基」、「C3 -C8 環烷基氧基」、「芳族C6 -C14 碳環基氧基」、「芳族5員至14員雜環基氧基」、「非芳族3員至14員雜環基氧基」指代式-O-R之基團，其中R對應地為如本文所定義之非芳族C3 -C12 碳環、C3 -C8 環烷基、芳族C6 -C14 碳環、芳族5員至14員雜環基或非芳族3員至14員雜環基。
如本文所使用，當基團被稱為「經取代」時，基團可經一或多個取代基取代。表述「一或多個取代基」係指可能基於可用的鍵結位點之數目，在一個至最多個數量的取代基範圍內之多個取代基，其限制條件為滿足穩定性及化學可行性之條件。
如本文所用之術語「脫離基」應理解為意謂在取代或消除反應中由化合物置換之基團，例如鹵素原子、三氟甲烷磺酸酯(「三氟甲磺酸酯」)基、烷氧基、甲烷磺酸酯、對甲苯磺酸酯等。
當術語「如本文所描述」指代變數Q 、T 、R1 、R2 、R3 、R4 、R5 、R6 、R7 、R8 時，n及m參考變數之廣泛定義以及較佳、更佳且甚至更佳的定義(若存在)。
式 ( I ) 之化合物 本發明係關於式(I)之化合物：
Figure 02_image005
其中T 為O或S；n 為0或1；m 為0或1； 限制條件為當n 為1時，m 為1；R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，其中Ra1 選自由以下組成之群：C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基，且Ra2 選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基；R2 及R3 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；R4 及R5 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；或R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環，且R3 及R5 獨立地為氫或鹵素；或R2 與R4 一起形成共價鍵且R3 及R5 獨立地為氫或C1 -C6 烷基；R6 係選自由以下組成之群：非芳族C3 -C12 碳環、芳族C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、非芳族C3 -C12 碳環基氧基、芳族C6 -C14 碳環基氧基、芳族5員至14員雜環基氧基、非芳族3員至14員雜環基氧基、經非芳族C3 -C12 碳環取代之C1 -C3 烷氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、經非芳族3員至14員雜環取代之C1 -C3 烷氧基、經芳族5員至14員雜環取代之C1 -C3 烷氧基、經非芳族C3 -C12 碳環取代之C1 -C3 鹵烷氧基、經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基、經非芳族3員至14員雜環取代之C1 -C3 鹵烷氧基及經芳族5員至14員雜環取代之C1 -C3 鹵烷氧基，其中R6 取代基之環狀或環狀部分可經一或多個可相同或不同之R6S 取代基取代，R6S 係選自由以下組成之群：鹵素、氰基、異氰基、硝基、羥基、巰基、五氟硫基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C3 -C8 環烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基磺醯基、C3 -C8 -環烷基、C3 -C8 環烷基氧基、C3 -C8 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環、非芳族3員或7員單環雜環、-N(Rc )2 、-C(=O)Rd 、-C(=O)(ORd )、-C(=O)N(Rd )2 、-S(=O)2 N(Rd )2 、-O-Si(C1 -C6 烷基)3 及-Si(C1 -C6 烷基)3 ，或兩個R6S 取代基可與其所連接之碳原子一起形成C3 -C8 環烷基， 其中Rc 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基， 其中Rd 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C1 -C6 鹵烷基， 其中脂族R6S 、Rc 及Rd 取代基可經一或多個獨立地選自由以下組成之群的取代基取代：氰基、羥基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、C3 -C8 環烷基、C3 -C8 鹵環烷基及非芳族3員至7員單環雜環， 其中R6S 及環狀Rc 取代基之環狀或環狀部分可經一或多個獨立地選自由以下組成之群的取代基取代：鹵素、氰基、硝基、羥基、甲醯基、羧基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C3 -C8 環烷基及C3 -C8 鹵環烷基，及/或R6S 取代基之環狀或環狀部分可經兩個取代基取代，其中兩個取代基與其所連接之碳原子一起形成C3 -C8 環烷基；R7 係選自由以下組成之群：氫、鹵素、氰基、異氰基、羥基、巰基、硝基、胺基、甲醯基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C3 -C8 環烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基磺醯基、C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、-N(Re )2 、-C(=NRf )Rf 、-NRg C(=O)Rg 、-C(=O)(ORg )、-C(=O)N(Rg )2 、-S(=O)2 N(Rg )2 及-S(=O)(=NRg )Rg ， 其中Re 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環， 其中Rf 獨立地選自由以下組成之群：羥基、胺基、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷胺基及二(C1 -C6 烷基)胺基， 其中Rg 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基及C3 -C8 環烷基， 其中脂族R7 、Re 、Rf 及Rg 取代基可經一或多個可相同或不同之R7Sa 取代基取代， 其中R7 之環狀或環狀部分、環狀Re 及環狀Rg 取代基可經一或多個可相同或不同之R7Sc 取代基取代，R7Sa 係選自由以下組成之群：氰基、羥基、羧基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C1 -C6 烷氧基羧基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、芳族C6 -C14 碳環及非芳族3員至7員單環雜環，R7Sc 係選自由以下組成之群：鹵素、氰基、硝基、羥基、甲醯基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 - 烯基、C3 -C8 環烷基、C3 -C8 鹵環烷基、-O-Si(C1 -C6 -烷基)3 及非芳族3至7員單環雜環，或兩個R7Sc 取代基與其所連接之碳原子一起形成C3 -C8 環烷基；R8 係選自由以下組成之群：氫、鹵素、氰基、異氰基、胺基、硝基、羥基、巰基、羧基、C1 -C6 烷氧羰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、非芳族3員至14員雜環基氧基、芳族5員至14員雜環基氧基、-O-Si(C1 -C6 -烷基)3 、-Si(C1 -C6 -烷基)3 、-N(Rh )2 、-SRi 、-S(=O)Ri 及-S(=O)2 Ri ， 其中Rh 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員至14員雜環及非芳族3員至7員單環雜環， 其中Ri 選自由以下組成之群：C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員至14員雜環及非芳族3員至7員單環雜環， 其中脂族R8 、Rh 及Ri 取代基可經一或多個可相同或不同之R8Sa 取代基取代， 其中R8 、環狀Rh 及環狀Ri 取代基之環狀或環狀部分可經一或多個可相同或不同之R8Sc 取代基取代，R8Sa 係選自由以下組成之群：氰基、胺基、硝基、羥基、甲醯基、羧基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、非芳族3員至7員單環雜環及-N(Ra ' )2 ，其中Ra ' 獨立地選自由以下組成之群：氫、甲醯基、C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C1 -C6 烷基羰基，其中該非芳族3員至7員單環雜環R8Sa 可經一或多個可相同或不同之C1 -C6 烷基取代基取代，R8Sc 係選自由以下組成之群：鹵素、氰基、胺基、硝基、羥基、甲醯基、羧基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、C3 -C8 鹵環烷基、-O-Si(C1 -C6 烷基)3 及非芳族3員至7員單環雜環，其可經一或多個可相同或不同之C1 -C6 烷基取代基取代，或兩個R8Sc 取代基與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環，其中該非芳族3員至7員單環雜環可經一或多個可相同或不同之C1 -C6 烷基取代基取代；Q 係選自由以下組成之群：芳族C6 -C14 碳環、非芳族C3 -C12 碳環、非芳族3員至14員雜環及芳族5員至14員雜環，其中該等碳環或雜環基中之任一者可經一或多個可相同或不同之QS 取代基取代，QS 係選自由以下組成之群：鹵素、氰基、異氰基、硝基、羥基、巰基、甲醯基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基、C3 -C8 環烷基氧基、C3 -C6 環烯基、非芳族3員至7員單環雜環、芳族5員至14員雜環、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、-O-C(=O)Rj 、-NRj C(=O)Rj 、-C(=O)N(Rj )2 、-C(=S)Rj 、-C(=S)N(Rj )2 、-C(=NRj )Rj 及-C(=NORj )Rj 及-N(Rk )2 其中Rj 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基及C1 -C6 烷氧基， 其中Rk 獨立地選自由以下組成之群：氫、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基及C3 -C8 環烷基， 其中脂族QS 、Rj 及Rk 取代基可經一或多個獨立地選自由以下組成之群的取代基取代：氰基、胺基、硝基、羥基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C3 -C8 環烷基、C3 -C8 鹵環烷基、-Si(C1 -C6 -烷基)3 及非芳族3員至7員單環雜環， 其中QS 及環狀Rk 取代基之環狀或環狀部分可經一或多個獨立地選自由以下組成之群的RQs 取代基取代：鹵素、氰基、胺基、硝基、羥基、甲醯基、羧基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C2 -C6 烯基及非芳族3員至7員單環雜環，其中環狀RQs 取代基可經兩個取代基取代，其中該兩個取代基與其所連接之碳原子一起形成C3 -C8 環烷基， 其限制條件為式(I)之化合物不為： (a) 3-(1H -苯并三唑-1-基氧基)-N-(4-第三丁基苯基)-6-氯嗒𠯤-4-甲醯胺([561297-99-2])； (b) 3-(環戊氧基)-6-(4-氟苯氧基)-N-{[(3R)-1-異丙基哌啶-3-基]甲基}嗒𠯤-4-甲醯胺([1336909-91-1])； (c) 6-(4-氟苯氧基)-N-{[(3R)-1-異丙基哌啶-3-基]甲基}-3-(四氫-2H-哌喃-4-基氧基)嗒𠯤-4-甲醯胺([1336909-90-0])； (d) 6-氯-N-{[(3R)-1-異丙基哌啶-3-基]甲基}-3-(四氫-2H-哌喃-4-基氧基)嗒𠯤-4-甲醯胺([1336910-48-5])； (e) 6-氯-3-(環戊氧基)-N-{[(3R)-1-異丙基哌啶-3-基]甲基}嗒𠯤-4-甲醯胺([1336910-49-6])； (f) 3-(1H-苯并三唑-1-基氧基)-6-氯-N-(環己基甲基)嗒𠯤-4-甲醯胺([1202404-84-9)]。
化合物(a) ([561297-99-2])作為適用於治療癌症之經取代芳基胺衍生物之製備中的中間物揭示於US2009/0143355中。
化合物(b)及(c) ([1336909-91-1]及[1336909-90-0]作為適用於治療糖尿病及肥胖症之饑餓素受體之潛在調節劑揭示於WO2011/117254中。化合物(d)及(e) ([1336910-48-5]及[1336910-49-6])作為用於製備饑餓素受體之潛在調節劑之中間物揭示於WO2011/117254中。
化合物(f)作為可用於製備發光裝置之組合物之組分揭示於US2011/0108767中。
將上文所揭示之實施例在本文中稱為「實施例1」。
本文中不涵蓋由組合所產生之化合物，該等化合物抵抗自然法則且熟習此項技術者將因此基於其(his/her)專家知識不包括。舉例而言，不包括具有三個或更多個相鄰氧原子之環結構。
式(I)之化合物可適合地處於其游離形式、鹽形式、N-氧化物形式或溶劑合物形式(例如，水合物)。
取決於取代基之性質，式(I)之化合物可以不同立體異構體之形式存在。此等立體異構體為例如對映異構體、非對映異構體、滯轉異構體或幾何異構體。因此，本發明涵蓋純立體異構體及此等異構體之任何混合物兩者。當化合物可以處於平衡之兩種或更多種互變異構體形式存在時，將藉助於一個互變異構描述對化合物之引用視為包括所有互變異構體形式。
視化合物中之雙鍵數而定，本發明化合物中之任一者亦可以一或多種幾何異構體形式存在。利用關於雙鍵或環之取代基之性質，幾何異構體可以順(=Z -)或反(=E -)形式存在。因此，本發明同樣係關於所有幾何異構體且係關於呈各種比例之所有可能的混合物。
視取代基之性質而定，式(I)之化合物可以游離化合物及/或其鹽(諸如農業化學上之活性鹽)之形式存在。
農業化學上之活性鹽包括無機及有機酸之酸加成鹽以及習用鹼之鹽。無機酸之實例為氫鹵酸(諸如氟化氫、氯化氫、溴化氫及碘化氫)、硫酸、磷酸及硝酸及酸性鹽(諸如硫酸氫鈉及硫酸氫鉀)。適用之有機酸包括例如甲酸、碳酸及烷酸(諸如乙酸、三氟乙酸、三氯乙酸及丙酸)及亦乙醇酸、硫氰酸、乳酸、丁二酸、檸檬酸、苯甲酸、肉桂酸、草酸、具有6至20個碳原子之飽和或單或二不飽和脂肪酸、烷基硫酸單酯、烷基磺酸(具有直鏈或分支鏈烷基的磺酸，該烷基具有1至20個碳原子)、芳基磺酸或芳基二磺酸(帶有一或兩個磺酸基之芳族基，諸如苯基及萘基)、烷基膦酸(具有直鏈或分支鏈烷基的膦酸，該膦酸具有1至20個碳原子)、芳基膦酸或芳基二膦酸(帶有一或兩個膦酸基之芳族基，諸如苯基及萘基)，其中烷基及芳基可帶有其他取代基，例如對甲苯磺酸、水楊酸、對胺基水楊酸、2-苯氧基苯甲酸、2-乙醯氧基苯甲酸等。
本發明化合物或其鹽之溶劑合物為化合物與溶劑之化學計量組合物。
本發明化合物可以多種結晶及/或非晶形式存在。結晶形式包括非溶合之結晶形式、溶劑合物及水合物。
如本文所使用之脂族R6S 取代基之表述「脂族R6S 、Rc 及Rd 取代基可經一或多個取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基及-Si(C1 -C6 烷基)3 及-O-Si(C1 -C6 烷基)3 之C1 -C6 烷基部分。
如本文所使用之脂族Rc 取代基之表述「脂族R6S 、Rc 及Rd 取代基可經一或多個取代基取代」指代C1 -C6 烷基。
如本文所使用之脂族Rd 取代基之表述「脂族R6S 、Rc 及Rd 取代基可經一或多個取代基取代」指代C1 -C6 烷基及C1 -C6 鹵烷基。
如本文所使用之脂族R7 取代基之表述「脂族R7 、Re 、Rf 及Rg 取代基可經一或多個R7Sa 取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基及-Si(C1 -C6 烷基)3 及-O-Si(C1 -C6 烷基)3 之C1 -C6 烷基部分。
如本文所使用之脂族Re 取代基之表述「脂族R7 、Re 、Rf 及Rg 取代基可經一或多個R7Sa 取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基及C2 -C6 鹵炔基。
如本文所使用之脂族Rf 取代基之表述「脂族R7 、Re 、Rf 及Rg 取代基可經一或多個R7Sa 取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基及C1 -C6 烷胺基及二(C1 -C6 烷基)胺基之C1 -C6 烷基部分。
如本文所使用之脂族Rg 取代基之表述「脂族R7 、Re 、及Rg 取代基可經一或多個R7Sa 取代基取代」指代C1 -C6 烷基及C1 -C6 鹵烷基。
如本文所使用之脂族R8 取代基之表述「脂族R8 、Rh 及Ri 取代基可經一或多個R8Sa 取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基及-Si(C1 -C6 烷基)3 及-O-Si(C1 -C6 烷基)3 之C1 -C6 烷基部分。
如本文所使用之脂族Rh 取代基之表述「脂族R8 、Rh 及Ri 取代基可經一或多個R8Sa 取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基及C2 -C6 鹵炔基。
如本文所使用之脂族Ri 取代基之表述「脂族R8 、Rh 及Ri 取代基可經一或多個R8Sa 取代基取代」指代C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基及C2 -C6 鹵炔基。
如本文所使用之脂族QS 取代基之表述「脂族QS 、Rj 及Rk 取代基可經一或多個取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基及-Si(C1 -C6 烷基)3 及-O-Si(C1 -C6 烷基)3 之C1 -C6 烷基部分。
如本文所使用之脂族Rj 取代基之表述「脂族QS 、Rj 及Rk 取代基可經一或多個取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基及C1 -C6 烷氧基。
如本文所使用之脂族Rk 取代基之表述「脂族QS 、Rj 及Rk 取代基可經一或多個取代基取代」指代C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基及C2 -C6 鹵烯基。
如本文所使用之環狀R6 取代基之表述「R6 之環狀或環狀部分取代基可經一或多個R6S 取代基取代」指代非芳族C3 -C12 碳環、芳族C6 -C14 碳環、非芳族3員至14員雜環及芳族5員至14員雜環。
如本文所使用之R6 取代基之環狀部分之表述「R6 之環狀或環狀部分取代基可經一或多個R6S 取代基取代」指代非芳族C3 -C12 碳環基氧基之非芳族C3 -C12 碳環、芳族C6 -C14 碳環基氧基之芳族C6 -C14 碳環、芳族5員至14員雜環基氧基之芳族5員至14員雜環、非芳族3員至14員雜環基氧基之非芳族3員至14員雜環、經非芳族C3 -C12 碳環取代之C1 -C3 烷氧基的非芳族C3 -C12 碳環、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基的芳族C6 -C14 碳環、經非芳族3員至14員雜環取代之C1 -C3 烷氧基的非芳族3員至14員雜環、經芳族5員至14員雜環取代之C1 -C3 烷氧基的芳族5員至14員雜環、經非芳族C3 -C12 碳環取代之C1 -C3 鹵烷氧基的非芳族C3 -C12 碳環、經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基的芳族C6 -C14 碳環、經非芳族3員至14員雜環取代之C1 -C3 鹵烷氧基的非芳族3員至14員雜環、及經芳族5員至14員雜環取代之C1 -C3 鹵烷氧基的芳族5員至14員雜環。
如本文所使用之環狀R6S 取代基之表述「環狀R6S 及Rc 取代基可經一或多個取代基取代」指代C3 -C8 環烷基、C3 -C8 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環。
如本文所使用之R6S 取代基之環狀部分之表述「R6S 之環狀或環狀部分及環狀Rc 取代基可經一或多個取代基取代」指代C3 -C8 環烷基氧基之C3 -C8 環烷基、C3 -C8 環烷基硫基、C3 -C8 環烷基亞磺醯基及C3 -C8 環烷基磺醯基。
如本文所使用之環狀Rc 取代基之表述「R6S 之環狀或環狀部分及環狀Rc 取代基可經一或多個取代基取代」指代C3 -C8 環烷基。
如本文所使用之環狀R7 取代基之表述「環狀R7 、Re 及Rg 取代基可經一或多個R7Sc 取代基取代」指代C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環。
如本文所使用之R7 取代基之環狀部分之表述「R7 之環狀或環狀部分、環狀Re 及環狀Rg 取代基可經一或多個R7Sc 取代基取代」指代C3 -C8 環烷基氧基之C3 -C8 環烷基、C3 -C8 環烷基硫基、C3 -C8 環烷基亞磺醯基及C3 -C8 環烷基磺醯基、芳族C6 -C14 碳環基氧基之芳族C6 -C14 碳環、芳族5員或6員單環雜環基氧基之芳族5員或6員單環雜環、及非芳族3員至7員單環雜環基氧基之非芳族3員至7員單環雜環。
如本文所使用之環狀Re 取代基之表述「環狀R7 、Re 及Rg 取代基可經一或多個R7Sc 取代基取代」指代C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環。
如本文所使用之環狀Rg 取代基之表述「環狀R7 、Re 及Rg 取代基可經一或多個R7Sc 取代基取代」指代C3 -C8 環烷基。
如本文所使用之環狀R8 取代基之表述「其中環狀R8 、Rh 及Ri 取代基可經一或多個R8Sc 取代基取代」指代C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、非芳族3員至14員雜環及芳族5員至14員雜環。
如本文所使用之R8 取代基之環狀部分之表述「其中R8 之環狀或環狀部分、環狀Rh 及環狀Ri 取代基可經一或多個R8Sc 取代基取代」指代C3 -C8 環烷基氧基之C3 -C8 環烷基、芳族C6 -C14 碳環基氧基之C6 -C14 碳環、非芳族3員至14員雜環基氧基之非芳族3員至14員雜環、及芳族5員至14員雜環基氧基之芳族5員至14員雜環。
如本文所使用之環狀Rh 取代基之表述「其中R8 之環狀或環狀部分、環狀Rh 及環狀Ri 取代基可經一或多個R8Sc 取代基取代」指代C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員至14員雜環及非芳族3員至7員單環雜環。
如本文所使用之環狀Ri 取代基之表述「其中環狀R8 、Rh 及Ri 取代基可經一或多個R8Sc 取代基取代」指代C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員至14員雜環及非芳族3員至7員單環雜環。
如本文所使用之環狀QS 取代基之表述「QS 之環狀或環狀部分及環狀Rk 取代基可經一或多個RQs 取代基取代」指代C3 -C8 環烷基、C3 -C6 環烯基、非芳族3員至7員單環雜環及芳族5員至14員雜環。
如本文所使用之QS 取代基之環狀部分之表述「QS 之環狀或環狀部分及環狀Rk 取代基可經一或多個RQs 取代基取代」指代C3 -C8 環烷基氧基之C3 -C8 環烷基。
如本文所使用之環狀Rk 取代基之表述「環狀QS 及Rk 取代基可經一或多個RQs 取代基取代」指代C3 -C8 環烷基。
當在本文中據稱R2 及R4 一起形成共價鍵時，獲得以下基團：-CR3 =CR5 -。
在上式(I)中，n 為0或1且m 為0或1，其限制條件為當n 為1時m 為1。因此，本發明係關於化合物，其中n為1且m為1，或n為0且m為1，或n為0且m為0。
在一些實施例中，在上式(I)中，R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基及-C(=O)(ORa1 )，其中Ra1 為C1 -C6 烷基或C2 -C6 烯基。
在上式(I)中，R1 較佳選自由以下組成之群：氫、羥基及-C(=O)(ORa1 )，其中Ra1 為C1 -C6 烷基或C2 -C6 烯基，更佳R1 為氫。
適合之R1 之非限制性實例包括揭示於表1之「R1 」行中的R1 基團中之任一者。
在上式(I)中，當存在時(亦即n=1)，R2 及R3 較佳獨立地選自由以下組成之群：氫、氰基、C1 -C6 烷基(例如甲基)及C1 -C6 烷氧羰基(例如甲氧基羰基)，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)。更佳地，當存在時，R2 及R3 均為氫，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)。
在上式(I)中，當存在時(亦即m=1)，R4 及R5 較佳獨立地選自由以下組成之群：氫、鹵素、羥基及C1 -C6 烷基(例如甲基)或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)或非芳族3員至7員單環雜環(例如非芳族3員至7員飽和單環雜環，舉例而言氧雜環丁烷基)。更佳地，當存在時，R4 及R5 獨立地選自由以下組成之群：氫、鹵素(例如氟)及C1 -C6 烷基(例如甲基)，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)。
在上式(I)中，當R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基時，R2 及R4 較佳形成環丙基且R3 及R5 獨立地為氫或鹵素(例如氟)。
在上式(I)中，R6 較佳選自由以下組成之群：非芳族C3 -C12 碳環、芳族C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基。
當R6 為非芳族C3 -C12 碳環時，R6 較佳為C7 -C12 多環系統，更佳為包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的C7 -C12 雙環系統，或包含經由一個共用原子與包含與C3 -C8 環烷基或C3 -C8 環烯基稠合之芳基的雙環系統連接之環丙基的C9 -C12 三環系統。
包含與C3 -C8 環烷基稠合之芳基的較佳C7 -C12 雙環系統包括二氫茚基、1,2,3,4-四氫萘基及雙環[4.2.0]辛-1(6),2,4-三烯基。
包含與C3 -C8 環烯基稠合之芳基的較佳C7 -C12 雙環系統包括茚基及1,2-二氫萘基。
包含經由一個共用原子連接至雙環系統之環丙基的較佳C9 -C12 三環系統包括螺[環丙烷-1,2'-二氫茚]-1-基及螺[環丙烷-1,2'-萘滿]-1-基，該雙環系統包含與C3 -C8 環烷基或C3 -C8 環烯基稠合之芳基。
當R6 為非芳族C3 -C12 碳環時，R6 更佳為二氫茚基、1,2,3,4-四氫萘基或螺[環丙烷-1,2'-二氫茚]-1-基，甚至更佳地R6 為二氫茚-1-基、二氫茚-2-基、1,2,3,4-四氫萘-1-基、1,2,3,4-四氫萘-2-基、1,2,3,4-四氫萘-6-基或螺[環丙烷-1,2'-二氫茚]-1-基。
當R6 為芳族C6 -C14 碳環時，R6 較佳為苯基或萘基，更佳為苯基、萘-1-基或萘-2-基。
當R6 為非芳族3員至14員雜環時，R6 通常為非芳族6員至14員多環雜環，R6 較佳為包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族雙環雜環、包含與3員至7員單環非芳族雜環稠合之5員或6員單環雜芳基的非芳族雙環雜環、包含經由一個共用原子與非芳族雙環雜環連接之環丙基的非芳族三環雜環，該雜環包含與芳基(例如苯基)稠合之4員至6員單環非芳族雜環、或包含經由一個共用原子與非芳族雙環雜環連接之環丙基的非芳族三環雜環，該非芳族雙環雜環包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基。
包含與芳基稠合之4至6員單環非芳族雜環之較佳非芳族雙環雜環包括2,3-二氫苯并呋喃基、2,3-二氫苯并噻吩基、吲哚啉基、1,3-苯并二氧雜環戊烯基、1,2,3,4-四氫喹啉基、𠳭烷基、異𠳭烷基、硫𠳭烷基及2,3-二氫-1,4-苯并二氧雜環己烯基。
包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的較佳非芳族雙環雜環包括四氫苯并噻吩基、6,7-二氫-5H-環戊[b]吡啶基、5,6,7,8-四氫喹啉基、4,5,6,7-四氫苯并噻吩基、4,5,6,7-四氫苯并呋喃基、4,5,6,7-四氫-1,3-苯并噁唑基、4,5,6,7-四氫-1,3-苯并噻唑基、4,5,6,7-四氫-1H-苯并咪唑基、4,5,6,7-四氫吲唑基、4,5,6,7-四氫-2H-異吲哚基、4,5,6,7-四氫-2-苯并噻吩基、5,6-二氫-4H-環戊[b]苯硫基及5,6-二氫-4H-環戊[d]噻唑基。
包含與3員至7員單環非芳族雜環稠合之5員或6員單環雜芳基的較佳非芳族雙環雜環包括4,5,6,7-四氫吡唑并[1,5-a]吡啶基、5,6,7,8-四氫-[1,2,4]三唑并[1,5-a]吡啶基、5,6,7,8-四氫咪唑并[1,2-a]吡啶基及6,7-二氫-5H-噻吩并[3,2-b]哌喃基。
包含經由一個共同原子與非芳族雙環雜環連接之環丙基的較佳非芳族三環雜環包括螺[𠳭烷-3,1'-環丙烷]-基，該非芳族雙環雜環包含與芳基稠合之4員至6員單環非芳族雜環。
包含經由一個共用原子與非芳族雙環雜環連接之環丙基的較佳非芳族三環雜環包括螺[7,8-二氫-5H-喹啉-6,1'-環丙烷]-基，該非芳族雙環雜環包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基。
當R6 為非芳族3員至14員雜環時，R6 更佳為與苯基稠合之4員至6員單環非芳族雜環(較佳地選自由以下組成之群：2,3-二氫苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、異𠳭烷基、硫𠳭烷基及2,3-二氫-1,4-苯并二氧雜環己烯基)或與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基(較佳地5,6,7,8-四氫喹啉基或4,5,6,7-四氫苯并噻吩基)。
當R6 為非芳族3員至14員雜環時，R6 甚至更佳為2,3-二氫苯并呋喃-3-基、2,3-二氫苯并呋喃基-5-基、2,3-二氫苯并呋喃基-7-基、吲哚啉-3-基、1,3-苯并二氧雜環戊烯-5-基、𠳭烷-4-基、異𠳭烷-4-基、硫代苯并二氫哌喃-4-基、2,3-二氫-1,4-苯并二氧雜環己烯-5-基、2,3-二氫-1,4-苯并二氧雜環己烯-6-基、5,6,7,8-四氫喹啉-8-基、4,5,6,7-四氫苯并噻吩-4-基或4,5,6,7-四氫苯并噻吩-7-基，更特定言之2,3-二氫苯并呋喃-5-基或4,5,6,7-四氫苯并噻吩-7-基。
當R6 為芳族5員至14員雜環時，R6 較佳為芳族5員或6員單環雜環、包含與芳基稠合之5員或6員單環芳族雜環之9員或10員芳族雙環雜環；或包含兩個稠合的5員或6員單環芳族雜環之9員或10員芳族雙環雜環。
較佳芳族5員或6員單環雜環包括呋喃基、噻吩基、吡唑基、咪唑基、三唑基、噁唑基、噁二唑基、噻唑基、噻二唑基、吡啶基、噠𠯤基及嘧啶基。
包含與芳基(苯基)稠合之芳族5員或6員單環雜環的較佳9員或10員芳族雙環雜環包括吲哚基、苯并咪唑基、吲唑基、苯并呋喃基、苯并噻吩基、苯并噻唑基(例如1,3-苯并噻唑基、2,1-苯并噻唑基、1,2-苯并噻唑基)、苯并噁唑基(例如1,3-苯并噁唑基、2,1-苯并噁唑基、1,2-苯并噁唑基)、喹啉基、異喹啉基及喹喏啉基。
包含兩個稠合的5員或6員單環芳族雜環之較佳9員或10員芳族雙環雜環包括吡咯并[3,2-c]吡啶基、咪唑并[1,2-a]吡啶基、[1,2,4]三唑并[4,3-a]吡啶基、咪唑并[1,2-a]吡啶基、噻吩并[3,2-b]吡咯基、噻吩并[3,2-b]苯硫基、咪唑并[2,1-b]噁唑基、呋喃并[2,3-d]異噁唑基及噻吩并[2,3-d]異噻唑基。
當R6 為芳族5員至14員雜環時，R6 更佳為芳族5員或6員單環雜環，其選自由以下組成之群：呋喃基、噻吩基、吡唑基、吡啶基及嘧啶基；包含與芳基稠合之5員或6員單環芳族雜環的9員或10員芳族雙環雜環，其選自由以下組成之群：吲哚基、苯并呋喃基、苯并噁唑基、喹啉基及異喹啉基，或咪唑并[1,2-a]吡啶基。
當R6 為芳族5員至14員雜環時，R6 甚至更佳為呋喃-2-基、噻吩-3-基、吡唑-4-基、吡啶-2-基、吡啶-3-基、嘧啶-2-基、喹啉-2-基、喹啉-3-基、喹啉-5-基、異喹啉-3-基、異喹啉-4-基、異喹啉-5-基、異喹啉-7-基、吲哚-3-基、苯并呋喃-4-基、1,3-苯并噁唑-4-基或咪唑并[1,2-a]吡啶-2-基，更特定言之R6 為吡啶-2-基、1,3-苯并噁唑-4-基或吲哚-3-基。
當R6 為芳族C6 -C14 碳環基氧基時，R6 較佳為苯氧基。
當R6 為經芳族C6 -C14 碳環取代之C1 -C3 烷氧基時，R6 較佳為經苯基，更佳苯甲氧基取代之C1 -C3 烷氧基。
當R6 為經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基時，R6 較佳為經苯基，更佳-OCF2 -苯基取代之C1 -C3 鹵烷氧基。
在一些實施例中，R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環、芳族C6 -C14 碳環(苯基、萘基)、非芳族多環6員至14員雜環、芳族5員至14員雜環、非芳族多環C7 -C12 碳環基氧基、苯氧基、芳族5員至14員雜環基氧基、非芳族多環6員至14員雜環基氧基、經非芳族多環C7 -C12 碳環取代之C1 -C3 烷氧基、經苯基或萘基取代之C1 -C3 烷氧基、經非芳族多環6員至14員雜環取代之C1 -C3 烷氧基、經芳族5員至14員雜環取代之C1 -C3 烷氧基、經非芳族多環C7 -C12 碳環取代之C1 -C3 烷氧基、經苯基或萘基取代之C1 -C3 鹵烷氧基、經非芳族多環6員至14員雜環取代之C1 -C3 鹵烷氧基、及經芳族5員至14員雜環取代之C1 -C3 鹵烷氧基。
在一些實施例中，R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環、芳族C6 -C14 碳環、非芳族6員至14員多環雜環、芳族5員至14員雜環、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基。
在一較佳實施例中，R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環、芳族C6 -C14 碳環、非芳族6員至14員多環雜環、芳族5員至14員雜環、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基。
在一些實施例中，R6 係選自由以下組成之群：二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷-1,2'-二氫茚]-1-基、苯基、萘基、2,3-二氫苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、異𠳭烷基、硫𠳭烷基、2,3-二氫-1,4-苯并二氧雜環己烯基、5,6,7,8-四氫喹啉基、4,5,6,7-四氫苯并噻吩基、呋喃基、噻吩基、吡啶基、嘧啶基、吲哚基、苯并呋喃基、苯并噁唑基、喹啉基、異喹啉基、咪唑并[1,2-a]吡啶基、苯氧基、苯甲氧基及-OCF2 -苯基。
在一更佳實施例中，R6 係選自由以下組成之群：二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷-1,2'-二氫茚]-1-基、苯基、萘基、2,3-二氫苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、異𠳭烷基、硫𠳭烷基、2,3-二氫-1,4-苯并二氧雜環己烯基、5,6,7,8-四氫喹啉基、4,5,6,7-四氫苯并噻吩基、呋喃基、噻吩基、吡啶基、嘧啶基、吲哚基、苯并呋喃基、苯并噁唑基、喹啉基、異喹啉基、咪唑并[1,2-a]吡啶基、苯氧基、苯甲氧基及-OCF2 -苯基。
在一些實施例中，R6 為
Figure 02_image007
其中R6s1 為氫或R6s ，R6s2 為氫或R6s ，R6s 如本文(上文或下文)所描述，較佳R6s1 及R6s2 中之至少一者不同於氫。
在一甚至更佳實施例中，R6 為
Figure 02_image009
其中R6s1 為氫或R6s ，R6s2 為氫或R6s ，R6s 為鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 鹵烷基硫基、C3 -C6 環烷基、苯基、吡啶基、吡唑基、咪唑基、三唑基、氧雜環丁烷基、四氫呋喃基及四氫哌喃基，其中環狀R6S 取代基可經一至三個獨立地選自由以下組成之群的取代基取代：鹵素、C1 -C6 烷基、C1 -C6 鹵烷基及C1 -C6 烷氧羰基， 其中限制條件為R6s1 及R6s2 中之至少一者不同於氫。
如本文中所揭示之R6 基團可經如上文所揭示或如下文所揭示之一或多個R6S 取代基取代。
在一些實施例中，R6 經一或多個可相同或不同之如上文所揭示或如下文所揭示之R6S 取代基取代。
R6S 取代基較佳選自由以下組成之群：鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基(例如環丙基、環丁基、環戊基、環己基)、芳族C6 -C14 碳環(例如苯基)、芳族5員或6員單環雜環(例如吡啶基、嘧啶基、噻吩基、呋喃基、咪唑基、三唑基、吡唑基、噁唑基、噻唑基,較佳地吡啶基、吡唑基、咪唑基、三唑基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基、四氫呋喃基、四氫哌喃基(氧雜環己基)、吡咯啶基、氮雜環丁烷基、嗎啉基，較佳地氧雜環丁烷基、四氫呋喃基、四氫哌喃基(氧雜環己基))，其中環狀R6S 取代基可經一或多個獨立地選自由以下組成之群的取代基取代：鹵素、C1 -C6 烷基、C1 -C6 鹵烷基及C1 -C6 烷氧羰基。
R6S 取代基更佳選自由以下組成之群：鹵素(例如氯、溴、碘、氟)、氰基、C1 -C6 烷基(例如甲基)、C1 -C6 鹵烷基(例如CF3 、CHF2 )、C1 -C6 烷氧基(例如甲氧基、異丙氧基)、C1 -C6 鹵烷氧基(例如二氟甲氧基)、C2 -C6 烯基(例如丙-1-烯-2-基)、C2 -C6 炔基(例如乙炔基)、C1 -C6 鹵烷基硫基(例如-SCH2 CF3 )、環丙基、環丁基、環戊基、環己基、苯基、吡啶-2-基、吡啶-4-基、吡唑-4-基、咪唑-2-基、三唑-4-基、氧雜環丁-3-基、四氫呋喃-3-基及四氫哌喃-4-基(噁烷-4-基)，其中環狀R6S 取代基可經一或多個獨立地選自由以下組成之群的取代基取代：鹵素(例如氯)、C1 -C6 烷基(例如甲基)、C1 -C6 鹵烷基(例如CF3 )及C1 -C6 烷氧羰基(例如甲氧羰基)。
適合之
Figure 02_image011
鏈之非限制性實例包括揭示於表1之「
Figure 02_image013
」行中的
Figure 02_image015
鏈中之任一者。
在上式(I)中，R7 較佳選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C3 -C8 環烷基、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 、-C(=NRf )Rf 及-C(=O)N(Rg )2 ， 其中Re 如上文所揭示，較佳地，Re 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基(例如環丙基)， 其中Rf 如上文所揭示，較佳地，Rf 獨立地選自由以下組成之群：羥基、胺基、C1 -C6 烷基及C1 -C6 烷氧基， 其中Rg 如上文所揭示，較佳地，Rg 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基(例如環丙基)。
當R7 為C3 -C8 環烷基時，R7 較佳為環丙基。
當R7 為芳族5員或6員單環雜環時，R7 較佳選自由以下組成之群：吡啶基、嘧啶基、噻吩基、呋喃基、咪唑基、三唑基、吡唑基、噁唑基及噻唑基，更佳地吡啶基(例如，吡啶-4-基)、咪唑基(例如，咪唑-1-基、咪唑-5-基)及吡唑基(例如，吡唑-4-基)。
當R7 為非芳族3員至7員單環雜環時，R7 較佳選自由以下組成之群：環氧乙烷基、氧雜環丁烷基、四氫呋喃基、四氫哌喃基、吡咯啶基、氮雜環丁烷基、氮丙啶基、嗎啉基及2-氧雜-6-氮雜螺[3.3]庚基，更佳氧雜環丁烷基(例如氧雜環丁基-3-基)、四氫呋喃基(例如四氫呋喃-3-基)、四氫哌喃基(例如四氫哌喃-4-基)、吡咯啶基(例如吡咯啶-1-基)及氮雜環丁烷基(例如氮雜環丁-1-基)。
當R7 為-N(Re )2 時，R7 較佳為二甲胺基或環丙胺基。
當R7 為-C(=NRf )Rf 時，R7 較佳為1-肼醯乙基、1-(甲氧基亞胺基)乙基或1-羥基亞胺基乙基。
當R7 為-C(=O)N(Rg )2 時，Rg 較佳獨立地選自由以下組成之群：氫、甲基、丙基及環丙基。
在一些實施例中，R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、環丙基、吡啶基、咪唑基、吡唑基、氧雜環丁烷基、四氫呋喃基、四氫哌喃基、吡咯啶基、氮雜環丁烷基、二甲胺基、環丙胺基、環丙胺基羰基、1-肼醯乙基、1-(甲氧亞胺基)乙基及1-羥亞胺基乙基。
如本文所揭示之較佳脂族R7 、Re 、Rf 及Rg 取代基可經一或多個如上文所揭示或如下文所揭示之R7Sa 取代基取代。
R7Sa 取代基較佳選自由以下組成之群：羥基、氰基、C1 -C6 烷氧基(例如甲氧基)、C3 -C8 環烷基(例如環丁基)、C1 -C6 烷氧羰基(例如乙氧羰基)及芳族C6 -C14 碳環(例如苯基)。
如本文所揭示之較佳環狀R7 及Re 取代基可經一或多個如上文所揭示或如下文所揭示之R7Sc 取代基取代。
R7Sc 取代基較佳選自由以下組成之群：鹵素(例如氟、氯)、羥基、C1 -C6 烷基(例如甲基)及C1 -C6 烷氧基(例如甲氧基)。
在一些實施例中，R7 為未經取代之吡啶基(例如吡啶-4-基)或經鹵素(例如氟、氯)、C1 -C6 烷基(例如甲基)或C1 -C6 烷氧基(例如甲氧基)取代之吡啶基。
在一些實施例中，R7 為未經取代之咪唑基(例如咪唑-1-基、咪唑-5-基)或經C1 -C6 烷基(例如甲基)取代之咪唑基。
在一些實施例中，R7 為未經取代之氮雜環丁烷基(例如氮雜環丁-1-基)或經羥基取代之氮雜環丁烷基。
適合之R7 之非限制性實例包括揭示於表1之「R7 」行中的R7 基團中之任一者。
在上式(I)中，R8 較佳選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、芳族C6 -C14 碳環、非芳族3員至14員雜環、a芳族5員至14員、C3 -C8 環烷氧基、非芳族3員至14員雜環基氧基及-N(Rh )2 ， 其中Rh 如上文所揭示，較佳地，Rh 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)。
當R8 為C3 -C8 環烷基時，R8 較佳為環丙基。
當R8 為芳族C6 -C14 碳環時，R8 較佳為苯基。
當R8 為非芳族3員至14員雜環時，R8 較佳為非芳族3員至7員單環雜環。
較佳非芳族3員至7員單環雜環包括環氧乙烷基、氮雜環丙烷基、氧雜環丁烷基、氮雜環丁烷基、四氫呋喃基、吡咯啶基、四氫哌喃基(氧雜環己烷基)及嗎啉基。
當R8 為非芳族3員至14員雜環時，R8 更佳選自由以下組成之群：氧雜環丁烷基、氮雜環丁烷基、吡咯啶基、四氫哌喃基及嗎啉基。
當R8 為非芳族3員至14員雜環時，R8 甚至更佳地選自由以下組成之群：氧雜環丁烷-3-基、氮雜環丁烷-1-基、四氫哌喃-4-基及吡咯啶-1-基。
當R8 為芳族5員至14員雜環時，R8 較佳為5員或6員芳族單環雜環。
較佳5員或6員芳族單環雜環包括呋喃基、噻吩基、吡唑基、咪唑基、三唑基、噁唑基、噻唑基、吡啶基及嘧啶基。
當R8 為芳族5員至14員雜環時，R8 更佳地選自由以下組成之群：吡唑基、咪唑基、噻唑基及吡啶基。
當R8 為芳族5員至14員雜環時，R8 甚至更佳地選自由以下組成之群：吡唑-1-基、咪唑-1-基、噻唑-4-基、吡啶-2-基、吡啶-3-基及吡啶-4-基。
當R8 為C3 -C8 環烷基氧基時，R8 較佳為環丙基氧基。
當R8 為非芳族3員至14員雜環基氧基時，R8 較佳為非芳族3員至7員單環雜環基氧基。
較佳非芳族3員至7員單環雜環基氧基包括氧雜環丁烷基氧基及氮雜環丁烷基氧基。
當R8 為非芳族3員至14員雜環基氧基時，R8 更佳為氧雜環丁烷-3-基氧基或氮雜環丁烷-3-基氧基。
當R8 為N(Rh )2 時，Rh 較佳獨立地選自由以下組成之群：氫、C1 -C6 烷基(例如甲基、乙基、丙基、異丁基)、C2 -C6 烯基(例如丁-3-烯-2-烯基)、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)。
在一些實施例中，R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、環丙基、苯基、氧雜環丁烷基、氮雜環丁烷基、吡咯啶基、四氫哌喃基、嗎啉基、吡唑基、咪唑基、噻唑基、吡啶基、環丙基氧基、氮雜環丁烷基氧基、氮雜環丁烷基氧基及-N(Rh )2 ，其中Rh 較佳獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)。
在一較佳實施例中，R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、環丙基、苯基、氧雜環丁烷基、氮雜環丁烷基、吡咯啶基、四氫哌喃基、嗎啉基、吡唑基、咪唑基、噻唑基、吡啶基、環丙基氧基、氮雜環丁烷基氧基、氮雜環丁烷基氧基及-N(Rh )2 ，其中Rh 較佳獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C6 環烷基、苯基及氧雜環丁烷基。
如本文所揭示之較佳脂族R8 及Rh 取代基可經一或多個如上文所揭示或如下文所揭示之R8Sa 取代基取代。
R8Sa 取代基較佳選自由以下組成之群：羥基、羧基、C1 -C6 鹵烷基(例如三氟甲基)、C1 -C6 烷氧基(例如甲氧基、乙氧基)、C1 -C6 烷氧基-C1 -C6 烷氧基(例如-乙氧基-甲氧基)、C1 -C6 烷氧羰基(例如甲氧羰基)、C3 -C8 環烷基(例如環丙基)、C1 -C6 烷基硫基(例如甲基磺醯基)、-O-Si(C1 -C6 烷基)3 、非芳族3員至7員單環雜環(例如1,3-二氧戊環基)及-N(Ra ' )2 ，其中Ra ' 較佳獨立地選自由以下組成之群：氫、甲醯基、C1 -C6 烷基(例如甲基)及C1 -C6 烷基羰基(例如甲基羰基)。
適合之N(Ra ' )2 基團之非限制性實例包括乙醯基(甲基)胺基及甲醯基(甲基)胺基。
較佳環狀R8 及Rh 取代基可經一或多個如上文或下文揭示之可相同或不同之R8Sc 取代基取代。
R8Sc 取代基較佳選自由以下組成之群：側氧基、鹵素(例如氯)、氰基、羥基、C1 -C6 烷基(例如甲基)、C1 -C6 鹵烷基(例如二氟甲基)、C1 -C6 烷氧基(例如甲氧基)、C1 -C6 烷氧羰基(例如乙氧基羰基、丙氧基羰基)、C3 -C8 環烷基(例如環丙基)及非芳族3員至7員單環雜環(例如氧雜環戊基、氧雜環丁烷基、四氫呋喃基)或兩個R8Sc 取代基與其所連接的碳原子一起形成非芳族3員至7員單環雜環(例如氧雜環丁烷基、環氧乙烷基)。
適合之R8 之非限制性實例包括揭示於表1之「R8 」行中的R8 基團中之任一者。
在上式(I)中，當Q 為芳族C6 -C14 碳環時，Q 較佳為苯基或萘基，更佳為苯基或萘-2-基。
在上式(I)中，當Q 為非芳族C3 -C12 碳環時，Q 較佳為包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統或包含與C3 -C8 環烯基稠合之芳基的C7 -C12 雙環系統。
包含與C3 -C8 環烷基稠合之芳基的較佳C7 -C12 雙環系統包括雙環[4.2.0]辛-1(6),2,4-三烯基、二氫茚基及1,2,3,4-四氫萘基。
包含與C3 -C8 環烯基稠合之芳基的較佳C7 -C12 雙環系統包括茚基及二氫萘基。
當Q 為非芳族C3 -C12 碳環時，Q 更佳為包含與C3 -C8 環烷基稠合之芳基(例如苯基)，甚至更佳雙環[4.2.0]辛-1(6),2,4-三烯基，更特定言之3-雙環[4.2.0]辛-1(6),2,4-三烯基之C7 -C12 雙環系統。
在上式(I)中，當Q 為非芳族3員至14員雜環時，Q 通常為非芳族6員至14員雙環雜環，較佳地Q 為包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環或包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族雙環雜環。 包含與芳基稠合之4至6員單環非芳族雜環之較佳非芳族雙環雜環包括2,3-二氫苯并呋喃基、1,3-二氫異苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、2,3-二氫-1,4-苯并二氧雜環己烯基及[1,3]二氧雜環戊并[4,5-b]吡啶基。 包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基之較佳非芳族雙環雜環包括5,6,7,8-四氫喹啉基及6,7-二氫-5H-環戊[b]吡啶基。 當Q 為非芳族3員至14員雜環時，Q 更佳為包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環，甚至更佳地Q 為1,3-苯并二氧雜環戊烯基或2,3-二氫苯并呋喃基，更特定言之Q 為1,3-苯并二氧雜環戊烯-5-基或2,3-二氫苯并呋喃基-5-基。
在上式(I)中，當Q 為芳族5員至14員雜環時，Q 較佳為芳族5員或6員單環雜環、包含與芳基(苯基)稠合之芳族5員或6員單環雜環的芳族9員或10員雙環雜環、或包含兩個稠合的芳族5員或6員單環雜環之9員或10員芳族雙環雜環。 較佳芳族5員或6員單環雜環包括吡咯基、呋喃基、噻吩基、咪唑基、三唑基、噁唑基、噻唑基、吡啶基、噠𠯤基及嘧啶基。 包含與芳基(苯基)稠合之芳族5員或6員單環雜環的較佳芳族9員或10員雙環雜環包括吲哚基、苯并咪唑基、吲唑基、苯并呋喃基、苯并噻吩基、苯并噻唑基(例如，1,2-苯并噻唑基、1,3-苯并噻唑基)、苯并噁唑基(例如，1,2-苯并噁唑基、1,3-苯并噁唑基)及喹啉基。 包含兩個稠合5員或6員單環芳族雜環之較佳芳族9員或10員雙環雜環包括呋喃并[3,2-b]吡啶基、噻吩并[3,2-b]苯硫基及噻吩并[2,3-d]噻唑基。 當Q 為芳族5員至14員雜環時，Q 更佳為芳族5員或6員單環雜環，甚至更佳地Q 為噻吩基、吡啶基或吲哚基，更特定言之Q 為吡啶-2-基、吡啶-3-基、噻吩-3-基、吲哚-5-基或吲哚-6-基。
在一些實施例中，Q 係選自由以下組成之群：芳族C6 -C14 碳環、包含與C3 -C8 環烷基稠合之芳基的非芳族C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的非芳族C7 -C12 雙環系統、包含與芳基稠合之4至6員單環非芳族雜環的非芳族6員至14員雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族6員或14員雙環雜環、芳族5員或6員單環雜環、包含與芳基稠合之芳族5員或6員單環雜環的芳族9員或10員雙環雜環、及包含兩個稠合的芳族5員或6員單環雜環之9員或10員芳族雙環雜環。
在一較佳實施例中，Q 係選自由以下組成之群：芳族C6 -C14 碳環、包含與C3 -C8 環烷基稠合之芳基的非芳族C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的非芳族C7 -C12 雙環系統、包含與芳基稠合之4至6員單環非芳族雜環的非芳族6員至14員雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族6員或14員雙環雜環、芳族5員或6員單環雜環、包含與芳基稠合之芳族5員或6員單環雜環的芳族9員或10員雙環雜環、及包含兩個稠合的芳族5員或6員單環雜環之9員或10員芳族雙環雜環。
在一些實施例中，Q 係選自由以下組成之群：苯基、萘基、雙環[4.2.0]辛-1(6),2,4-三烯基、苯并二氧雜環戊烯基、2,3-二氫苯并呋喃基、吡啶基、噻吩基及吲哚基，較佳地Q 為苯基、萘-2-苯基、3-雙環[4.2.0]辛-1(6),2,4-三烯基、1,3-苯并二氧雜環戊烯-5-基、2,3-二氫苯并呋喃-5-基、吡啶-2-基、吡啶-3-基、噻吩-3-基、吲哚-5-基或吲哚-6-基。
在一更佳實施例中，Q 係選自由以下組成之群：苯基、萘基、雙環[4.2.0]辛-1(6),2,4-三烯基、苯并二氧雜環戊烯基、2,3-二氫苯并呋喃基、吡啶基、噻吩基及吲哚基。
在一甚至更佳實施例中，Q 係選自由以下組成之群：苯基、萘-2-基、3-雙環[4.2.0]辛-1(6),2,4-三烯基、1,3-苯并二氧雜環戊烯-5-基、2,3-二氫苯并呋喃-5-基、吡啶-2-基、吡啶-3-基、噻吩-3-基、吲哚-5-基或吲哚-6-基。
如本文中所揭示之Q 基團可經如上文所揭示或如下文所揭示之可相同或不同之一或多個QS 取代基取代。
在一些實施例中，Q 經一或多個如上文所揭示或如下文所揭示之可相同或不同之QS 取代基取代。
QS 取代基較佳選自由以下組成之群：鹵素(例如氟、氯、溴、碘)、氰基、硝基、羥基、C1 -C6 烷基 (例如甲基、乙基)、C1 -C6 鹵烷基(例如三氟甲基、二氟甲基)、C1 -C6 烷基羰基(例如甲基羰基)、C1 -C6 烷氧基(例如甲氧基)、C1 -C6 鹵烷氧基(例如二氟甲氧基、三氟甲氧基)、C1 -C6 烷氧基-C1 -C6 烷基(例如甲氧基甲基)、C2 -C6 烯基(例如乙烯基)、C2 -C6 炔基(例如乙炔基)、C1 -C6 烷基硫基(例如甲基硫基)、C1 -C6 鹵烷基硫基(例如三氟甲基硫基)、C3 -C8 環烷基(例如環丙基、環丁基)、非芳族3員至7員單環雜環(例如環氧乙烷基、氧雜環丁烷基)及-N(Rk )2 ，其中Rk 為氫。
脂族QS 取代基可如本文中所揭示經取代。
環狀QS 取代基可如本文所揭示經取代或較佳經一或多個鹵素原子(例如氟)取代。
適合之Q 之非限制性實例包括揭示於表1之「Q 」行中的Q 基團中之任一者。
在一些實施例中，Q 為
Figure 02_image017
其中Qs1 為氫或鹵素(較佳為氟)，Qs2 為氫或Qs ，其中Qs 為如上文所描述，較佳地QS2 係選自由以下組成之群：氫、鹵素(例如氟、氯、溴、碘)、氰基、硝基、羥基、胺基、C1 -C6 烷基(例如甲基、乙基)、C1 -C6 鹵烷基(例如三氟甲基、二氟甲基)、C1 -C6 烷基羰基(例如甲基羰基)、C1 -C6 烷氧基(例如甲氧基)、C1 -C6 鹵烷氧基(例如二氟甲氧基、三氟甲氧基)、C1 -C6 烷氧基-C1 -C6 烷基(例如甲氧基甲基)、C2 -C6 烯基(例如乙烯基)、C2 -C6 炔基(例如乙炔基)、C1 -C6 烷基硫基(例如甲基硫基)、C1 -C6 鹵烷基硫基(例如三氟甲基硫基)、可經一或多個鹵素原子取代之C3 -C8 環烷基(例如環丙基、環丁基)、及可經一或多個鹵素原子取代之非芳族3員至7員單環雜環(例如環氧乙烷基、氧雜環丁烷基)，更佳地，QS2 係選自由以下組成之群：氟、氯、溴、碘、氰基、硝基、羥基、胺基、甲基、三氟甲基、二氟甲基、甲氧基、二氟甲氧基、三氟甲氧基、乙烯基、乙炔基、甲基磺醯基、三氟甲基硫基、可經一或多個鹵素原子取代之環丙基、可經一或多個鹵素原子取代之環氧乙烷基及氧雜環丁烷基，較佳地Qs1 及Qs2 中之至少一者與氫不同。
在一甚至更佳實施例中，Q 為
Figure 02_image019
其中Qs1 為氫或鹵素，Qs2 為氫或Qs ，其中Qs 係選自由以下組成之群：氫、鹵素、氰基、硝基、羥基、胺基、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 烷基羰基、C1 -C4 烷氧基、C1 -C4 鹵烷氧基、C1 -C4 烷氧基-C1 -C4 烷基、C2 -C4 烯基、C2 -C4 炔基、C1 -C4 烷基硫基、C1 -C4 鹵烷基硫基、可經一或兩個鹵素原子取代之C3 -C6 環烷基、及可經一或兩個鹵素原子取代之非芳族3員至6員單環雜環，其限制條件為Qs1 及Qs2 中之至少一者與氫不同。
最佳地，QS2 係選自由以下組成之群：氟、氯、溴、碘、氰基、硝基、羥基、胺基、甲基、三氟甲基、二氟甲基、甲氧基、二氟甲氧基、三氟甲氧基、乙烯基、乙炔基、甲基硫基、三氟甲基硫基、可經一或兩個鹵素原子取代之環丙基、可經一或兩個鹵素原子取代之環氧乙烷基及氧雜環丁烷基。
R1 、R2 、R3 、R4 、R5 、R6 、R7 ,R8 及Q 之以上指定定義(廣泛定義以及較佳、更佳、甚至更佳定義)可以各種方式組合。因此，定義之此等組合提供根據本發明之化合物的子類別，諸如下文所揭示之化合物。
在一些實施例(在本文中稱為實施例2)中，根據本發明之化合物為式(I)之化合物：
Figure 02_image021
其中T 為O或S；n 為0或1；m 為0或1； 限制條件為當n 為1時，m 為1；R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，其中Ra1 選自由以下組成之群：C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基，且Ra2 選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基；R2 及R3 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；R4 及R5 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；或R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環，且R3 及R5 獨立地為氫或鹵素原子；或R2 與R4 一起形成共價鍵且R3 及R5 獨立地為氫或C1 -C6 烷基；R6 係選自由以下組成之群：非芳族C3 -C12 碳環(較佳C7 -C12 雙環系統，更佳包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的C7 -C12 雙環系統或包含經由一個共用原子連接至雙環系統之環丙基的C9 -C12 三環系統，該雙環系統包含與C3 -C8 環烷基或C3 -C8 環烯基稠合之芳基)、芳族C6 -C14 碳環(較佳苯基或萘基)、非芳族3員至14員雜環(較佳非芳族6員至14員多環雜環，更佳包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族雙環雜環、包含與3員至7員單環非芳族雜環稠合之5員或6員單環雜芳基的非芳族雙環雜環、包含經由一個共用原子連接至非芳族雙環雜環之環丙基的非芳族三環雜環，該雜環包含與芳基稠合之4員至6員單環非芳族雜環、或包含經由一個共用原子連接至非芳族雙環雜環之環丙基的非芳族三環雜環，該雙環雜環包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基)、芳族5員至14員雜環(較佳為5員或6員單環芳族雜環、包含與芳基稠合之5員或6員單環芳族雜環的9員或10員芳族雙環雜環、包含兩個稠合5員或6員單環芳族雜環的9員或10員芳族雙環雜環)、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基，較佳地R6 係選自由以下組成之群：二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷1,2'-二氫茚]-1-基、苯基、萘基、2,3-二氫苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、異𠳭烷基、硫𠳭烷基、2,3-二氫-1,4-苯并二氧雜環己烯基、5,6,7,8-四氫喹啉基、4,5,6,7-四氫苯并噻吩基、呋喃基、噻吩基、吡啶基、嘧啶基、吲哚基、苯并呋喃基、苯并噁唑基、喹啉基、異喹啉基、咪唑并[1,2-a]吡啶基、苯氧基、苯甲氧基及-OCF2 -苯基， 其中R6 取代基之環狀或環狀部分可經一或多個可相同或不同之R6S 取代基取代，R6S 如本文所揭示(包括較佳及更佳R6S )；R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C3 -C8 環烷基、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 、-C(=NRf )Rf 及-C(=O)N(Rg )2 ， 其中Re 如上文所揭示，較佳地Re 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基(例如環丙基)， 其中Rf 如上文所揭示，較佳地，Rf 獨立地選自由以下組成之群：羥基、胺基、C1 -C6 烷基及C1 -C6 烷氧基， 其中Rg 如上文所揭示，較佳地，Rg 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基， 較佳地，R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、環丙基、吡啶基、咪唑基、吡唑基、氧雜環丁烷基、四氫呋喃基、四氫哌喃基、吡咯啶基、氮雜環丁烷基、二甲胺基、環丙胺基、環丙胺基羰基、1-肼醯乙基、1-(甲氧亞胺基)乙基及1-羥亞胺基乙基， 其中脂族R7 、Re 、Rf 及Rg 取代基可經一或多個可相同或不同之R7Sa 取代基取代，R7Sa 如本文所揭示(包括較佳R7Sa )， 其中R7 之環狀或環狀部分、環狀Re 及環狀Rg 取代基可經一或多個可相同或不同之R7Sc 取代基取代，R7Sc 如本文所揭示(包括較佳R7Sc )；R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、芳族C6 -C14 碳環、非芳族3員至14員雜環(較佳地非芳族3員至7員單環雜環)、芳族5員至14員雜環(較佳地5員或6員芳族單環雜環)、C3 -C8 環烷基氧基、非芳族3員至14員雜環基氧基(較佳地非芳族3員至7員單環雜環基氧基)及-N(Rh )2 ，其中Rh 如上文所揭示，較佳地，Rh 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)， 較佳地，R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 -烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、環丙基、苯基、氧雜環丁烷基、氮雜環丁烷基、吡咯啶基、四氫哌喃基、嗎啉基、吡唑基、咪唑基、噻唑基、吡啶基、環丙基氧基、氧雜環丁烷基氧基、氮雜環丁烷基氧基及-N(Rh )2 ，其中Rh 較佳獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)， 其中脂族R8 及Rh 取代基可經一或多個可相同或不同之R8Sa 取代基取代，R8Sa 如本文所揭示(包括較佳R8Sa )， 其中R8 之環狀或環狀部分及環狀Rh 取代基可經一或多個可相同或不同之R8Sc 取代基取代，R8Sc 如本文中所揭示(包括較佳R8Sc )；Q 係選自由以下組成之群：芳族C6 -C14 碳環、包含與C3 -C8 環烷基稠合之芳基的非芳族C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的非芳族C7 -C12 雙環系統、包含與芳基稠合之4員至6員單環非芳族雜環的6員至14員非芳族雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的6員至14員非芳族雙環雜環、芳族5員或6員單環雜環、包含與芳基(苯基)稠合之5員或6員單環芳族雜環的9員或10員芳族雙環雜環、包含兩個稠合的5員或6員單環芳族雜環的9員或10員芳族雙環雜環，較佳地Q 係選自由以下組成之群：芳族C6 -C14 碳環、包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統、包含與芳基稠合之4員至6員單環非芳族雜環的6員至14員非芳族雙環雜環及芳族5員或6員單環雜環，更佳地Q 係選自由以下組成之群：苯基、萘基、3-雙環[4.2.0]辛-1(6),2,4-三烯基、1,3-苯并二氧雜環戊烯基、2,3-二氫苯并呋喃基、吡啶基、噻吩基及吲哚基， 其中各Q 基團可經一或多個可相同或不同之QS 取代基取代，QS 如本文所描述(包括較佳QS )。
在一些實施例(在本文中稱為實施例3)中，根據本發明之化合物為式(I)之化合物：
Figure 02_image023
其中T 為O或S；n 為0或1；m 為0或1； 限制條件為當n 為1時，m 為1；R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，其中Ra1 選自由以下組成之群：C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基，且Ra2 選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基；R2 及R3 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；R4 及R5 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；或R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環，且R3 及R5 獨立地為氫或鹵素原子；或R2 與R4 一起形成共價鍵且R3 及R5 獨立地為氫或C1 -C6 烷基；R6 係選自由以下組成之群：非芳族C3 -C12 碳環(較佳C7 -C12 雙環系統，更佳包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的C7 -C12 雙環系統或包含經由一個共用原子連接至雙環系統之環丙基的C9 -C12 三環系統，該雙環系統包含與C3 -C8 環烷基或C3 -C8 環烯基稠合之芳基)、芳族C6 -C14 碳環(較佳苯基或萘基)、非芳族3員至14員雜環(較佳非芳族6員至14員多環雜環，更佳包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族雙環雜環、包含與3員至7員單環非芳族雜環稠合之5員或6員單環雜芳基的非芳族雙環雜環、包含經由一個共用原子連接至非芳族雙環雜環之環丙基的非芳族三環雜環，該雜環包含與芳基稠合之4員至6員單環非芳族雜環、或包含經由一個共用原子連接至非芳族雙環雜環之環丙基的非芳族三環雜環，該雙環雜環包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基)、芳族5員至14員雜環(較佳為5員或6員單環芳族雜環、包含與芳基稠合之5員或6員單環芳族雜環的9員或10員芳族雙環雜環、包含兩個稠合5員或6員單環芳族雜環的9員或10員芳族雙環雜環)、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基，較佳地R6 係選自由以下組成之群：二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷1,2'-二氫茚]-1-基、苯基、萘基、2,3-二氫苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、異𠳭烷基、硫𠳭烷基、2,3-二氫-1,4-苯并二氧雜環己烯基、5,6,7,8-四氫喹啉基、4,5,6,7-四氫苯并噻吩基、呋喃基、噻吩基、吡啶基、嘧啶基、吲哚基、苯并呋喃基、苯并噁唑基、喹啉基、異喹啉基、咪唑并[1,2-a]吡啶基、苯氧基、苯甲氧基及-OCF2 -苯基， 其中R6 取代基之環狀或環狀部分可經一或多個可相同或不同之R6S 取代基取代，R6S 如本文所揭示(包括較佳及更佳R6S )；R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C3 -C8 環烷基、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 、-C(=NRf )Rf 及-C(=O)N(Rg )2 ， 其中Re 如上文所揭示，較佳地Re 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基(例如環丙基)， 其中Rf 如上文所揭示，較佳地Rf 獨立地選自由以下組成之群：羥基、胺基、C1 -C6 烷基及C1 -C6 烷氧基， 其中Rg 如上文所揭示，較佳地，Rg 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基， 較佳地，R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、環丙基、吡啶基、咪唑基、吡唑基、氧雜環丁烷基、四氫呋喃基、四氫哌喃基、吡咯啶基、氮雜環丁烷基、二甲胺基、環丙胺基、環丙胺基羰基、1-肼醯乙基、1-(甲氧亞胺基)乙基及1-羥亞胺基乙基， 其中脂族R7 、Re 、Rf 及Rg 取代基可經一或多個可相同或不同之R7Sa 取代基取代，R7Sa 如本文所揭示(包括較佳R7Sa )， 其中R7 之環狀或環狀部分、環狀Re 及環狀Rg 取代基可經一或多個可相同或不同之R7Sc 取代基取代，R7Sc 如本文所揭示(包括較佳R7Sc )；R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、芳族C6 -C14 碳環、非芳族3員至14員雜環(較佳地非芳族3員至7員單環雜環)、芳族5員至14員雜環(較佳地5員或6員芳族單環雜環)、C3 -C8 環烷基氧基、非芳族3員至14員雜環基氧基(較佳地非芳族3員至7員單環雜環基氧基)及-N(Rh )2 ， 其中Rh 如上文所揭示，較佳地，Rh 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)， 較佳地，R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 -烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、環丙基、苯基、氧雜環丁烷基、氮雜環丁烷基、吡咯啶基、四氫哌喃基、嗎啉基、吡唑基、咪唑基、噻唑基、吡啶基、環丙基氧基、氧雜環丁烷基氧基、氮雜環丁烷基氧基及-N(Rh )2 ，其中Rh 較佳獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)， 其中脂族R8 及Rh 取代基可經一或多個可相同或不同之R8Sa 取代基取代，R8Sa 如本文所揭示(包括較佳R8Sa )， 其中R8 之環狀或環狀部分及環狀Rh 取代基可經一或多個可相同或不同之R8Sc 取代基取代，R8Sc 如本文所揭示(包括較佳R8Sc )；Q 為
Figure 02_image025
其中Qs1 為氫或鹵素(較佳為氟)，Qs2 為氫或Qs ，其中Qs 係如上文所描述，較佳地QS2 係選自由以下組成之群：氫、鹵素(例如氟、氯、溴、碘)、氰基、硝基、羥基、胺基、C1 -C6 烷基(例如甲基、乙基)、C1 -C6 鹵烷基(例如三氟甲基、二氟甲基)、C1 -C6 烷基羰基(例如甲基羰基)、C1 -C6 烷氧基(例如甲氧基)、C1 -C6 鹵烷氧基(例如二氟甲氧基、三氟甲氧基)、C1 -C6 烷氧基-C1 -C6 烷基(例如甲氧基甲基)、C2 -C6 烯基(例如乙烯基)、C2 -C6 炔基(例如乙炔基)、C1 -C6 烷基硫基(例如甲基硫基)、C1 -C6 鹵烷基硫基(例如三氟甲基硫基)、可經一或多個鹵素原子取代之C3 -C8 環烷基(例如環丙基、環丁基)、及可經一或多個鹵素原子取代之非芳族3員至7員單環雜環(例如氧雜環丁烷基)，更佳地，QS2 係選自由以下組成之群：氟、氯、溴、碘、氰基、硝基、羥基、胺基、甲基、三氟甲基、二氟甲基、甲氧基、三氟甲氧基、乙烯基、乙炔基、甲基磺醯基、三氟甲基硫基、可經一或多個鹵素原子取代之環丙基、及可經一或多個鹵素原子取代之氧雜環丁烷基，較佳地Qs1 及Qs2 中之至少一者與氫不同。
在一些實施例(在本文中稱為實施例4)中，根據本發明之化合物為式(I)之化合物：
Figure 02_image027
其中T 為O或S；n 為0或1；m 為0或1； 限制條件為當n 為1時，m 為1；R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，其中Ra1 選自由以下組成之群：C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基，且Ra2 選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基；R2 及R3 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；R4 及R5 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；或R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環，且R3 及R5 獨立地為氫或鹵素原子；或R2 與R4 一起形成共價鍵且R3 及R5 獨立地為氫或C1 -C6 烷基；R6 為
Figure 02_image029
其中R6s1 為氫或R6s ，R6s2 為氫或R6s ，R6s 如本文所描述(包括較佳及更佳R6s )，較佳R6s1 及R6s2 中之至少一者與氫不同，R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C3 -C8 環烷基、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 、-C(=NRf )Rf 及-C(=O)N(Rg )2 ， 其中Re 如上文所揭示，較佳地Re 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基(例如環丙基)， 其中Rf 如上文所揭示，較佳地Rf 獨立地選自由以下組成之群：羥基、胺基、C1 -C6 烷基及C1 -C6 烷氧基， 其中Rg 如上文所揭示，較佳地，Rg 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基， 較佳地，R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、環丙基、吡啶基、咪唑基、吡唑基、氧雜環丁烷基、四氫呋喃基、四氫哌喃基、吡咯啶基、氮雜環丁烷基、二甲胺基、環丙胺基、環丙胺基羰基、1-肼醯乙基、1-(甲氧亞胺基)乙基及1-羥亞胺基乙基， 其中脂族R7 、Re 、Rf 及Rg 取代基可經一或多個可相同或不同之R7Sa 取代基取代，R7Sa 如本文所揭示(包括較佳R7Sa )， 其中R7 之環狀或環狀部分、環狀Re 及環狀Rg 取代基可經一或多個可相同或不同之R7Sc 取代基取代，R7Sc 如本文所揭示(包括較佳R7Sc )；R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、芳族C6 -C14 碳環、非芳族3員至14員雜環(較佳地非芳族3員至7員單環雜環)、芳族5員至14員雜環(較佳地5員或6員芳族單環雜環)、C3 -C8 環烷基氧基、非芳族3員至14員雜環基氧基(較佳地非芳族3員至7員單環雜環基氧基)及-N(Rh )2 ， 其中Rh 如上文所揭示，較佳地，Rh 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)， 較佳地，R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 -烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、環丙基、苯基、氧雜環丁烷基、氮雜環丁烷基、吡咯啶基、四氫哌喃基、嗎啉基、吡唑基、咪唑基、噻唑基、吡啶基、環丙基氧基、氧雜環丁烷基氧基、氮雜環丁烷基氧基及-N(Rh )2 ，其中Rh 較佳獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基(例如環丙基、環己基)、芳族C6 -C14 碳環(例如苯基)及非芳族3員至7員單環雜環(例如氧雜環丁烷基)， 其中脂族R8 及Rh 取代基可經一或多個可相同或不同之R8Sa 取代基取代，R8Sa 如本文所揭示(包括較佳R8Sa )， 其中R8 之環狀或環狀部分及環狀Rh 取代基可經一或多個可相同或不同之R8Sc 取代基取代，R8Sc 如本文所揭示(包括較佳R8Sc )；Q 為
Figure 02_image031
其中Qs1 為氫或鹵素(較佳為氟)，Qs2 為氫或Qs ，其中Qs 為如上文所描述，較佳地QS2 係選自由以下組成之群：氫、鹵素(例如氟、氯、溴、碘)、氰基、硝基、羥基、胺基、C1 -C6 烷基(例如甲基、乙基)、C1 -C6 鹵烷基(例如三氟甲基、二氟甲基)、C1 -C6 烷基羰基(例如甲基羰基)、C1 -C6 烷氧基(例如甲氧基)、C1 -C6 鹵烷氧基(例如二氟甲氧基、三氟甲氧基)、C1 -C6 烷氧基-C1 -C6 烷基(例如甲氧基甲基)、C2 -C6 烯基(例如乙烯基)、C2 -C6 炔基(例如乙炔基)、C1 -C6 烷基硫基(例如甲基硫基)、C1 -C6 鹵烷基硫基(例如三氟甲基硫基)、可經一或多個鹵素原子取代之C3 -C8 環烷基(例如環丙基、環丁基)、及可經一或多個鹵素原子取代之非芳族3員至7員單環雜環(例如環氧乙烷基、氧雜環丁烷基)，更佳地，QS2 係選自由以下組成之群：氟、氯、溴、碘、氰基、硝基、羥基、胺基、甲基、三氟甲基、二氟甲基、甲氧基、二氟甲氧基、三氟甲氧基、乙烯基、乙炔基、甲基磺醯基、三氟甲基硫基、可經一或多個鹵素原子取代之環丙基、及可經一或多個鹵素原子取代之氧雜環丁烷基，較佳地Qs1 及Qs2 中之至少一者與氫不同。
在一較佳實施例中，根據本發明之化合物為式(I)之化合物，其中T 為O或S；n 為0或1；m 為0或1； 限制條件為當n 為1時，m 為1；R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基及-C(=O)(ORa1 )，其中Ra1 選自由以下組成之群：C1 -C6 烷基及C2 -C6 烯基，R2 及R3 獨立地選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基及C1 -C6 烷氧羰基，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基，R4 及R5 獨立地選自由以下組成之群：氫、鹵素及C1 -C6 烷基，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；或R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基，且R3 及R5 獨立地為氫或鹵素；或R6 係選自由以下組成之群：非芳族C3 -C12 碳環、芳族C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、經非芳族C3 -C12 碳環取代之C1 -C3 鹵烷氧基、經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基，其中R6 取代基之環狀或環狀部分可經一個或三個可相同或不同之R6S 取代基取代，R6S 係選自由以下組成之群：鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環， 其中R6S 取代基之環狀或環狀部分可經一至三個獨立地選自由以下組成之群的取代基取代：鹵素、C1 -C6 烷基、C1 -C6 鹵烷基及C1 -C6 烷氧羰基，R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基、芳族5員或6員單環雜環、非芳族3員至7員單環雜環及-N(Re )2 ， 其中Re 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基及C3 -C8 環烷基， 其中脂族R7 及Re 取代基可經一至三個獨立地選自由以下組成之群的R7Sa 取代基取代：氰基、羥基、C1 -C6 烷氧基、C3 -C8 環烷基、C1 -C6 烷氧羰基及芳族C6 -C14 碳環， 其中R7 之環狀或環狀部分及環狀Re 可經一至三個獨立地選自由以下組成之群的R7Sc 取代基取代：鹵素、羥基、C1 -C6 烷基及C1 -C6 烷氧基，R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、芳族 C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、C3 -C8 環烷基氧基、非芳族3員至14員雜環基氧基及-N(Rh )2 ， 其中Rh 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C2 -C6 烯基、C3 -C8 環烷基、芳族C6 -C14 碳環及非芳族3員至7員單環雜環， 其中脂族R8 及Rh 取代基可經一至三個獨立地選自由以下組成之群的R8Sa 取代基取代：羥基、羧基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷氧基、C1 -C6 烷氧羰基、C3 -C8 環烷基、-O-Si(C1 -C6 烷基)3 、非芳族3員至7員單環雜環及-N(Ra ' )2 ，其中Ra ' 獨立地選自由以下組成之群：氫、甲醯基、C1 -C6 烷基及C1 -C6 烷基羰基， 其中R8 之環狀或環狀部分及環狀Rh 取代基可經一至三個獨立地選自由以下組成之群的R8Sc 取代基取代：鹵素、氰基、羥基、側氧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基、C3 -C8 環烷基及非芳族3員至7員單環雜環，或兩個R8Sc 取代基與其所連接之碳原子一起形成非芳族3員至7員單環雜環，Q 係選自由以下組成之群：苯基、萘基、包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的C7 -C12 雙環系統、包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族雙環雜環、芳族5員或6員單環雜環、包含與芳基(苯基)稠合之芳族5員或6員單環雜環的芳族9員或10員雙環雜環、包含兩個稠合的芳族5員或6員單環雜環之9員或10員芳族雙環雜環，其中該碳環或雜環基團中之任一者可經一至四個獨立地選自由以下組成之群的QS 取代基取代：鹵素、氰基、硝基、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、非芳族3員至7員單環雜環及-N(Rk )2 其中Rk 為氫， 其中QS 取代基之環狀或環狀部分可經一至三個獨立地選自由鹵素組成之群的RQs 取代基取代。
在一更佳實施例中，根據本發明之化合物為式(I)之化合物，其中T 為O；n 為0或1；m 為0或1； 限制條件為當n 為1時，m 為1；R1 係選自由以下組成之群：氫、羥基、C1 -C烷基及-C(=O)(ORa1 )，其中Ra1 選自由以下組成之群：C1 -C4 烷基及C2 -C4 烯基，R2 及R3 為氫，或R2 及R3 與其所連接之碳原子一起形成C3 -C6 環烷基，R4 及R5 獨立地選自由以下組成之群：氫、氟、氯及C1 -C4 烷基，或R4 及R5 與其所連接之碳原子一起形成C3 -C6 環烷基；或R2 及R4 與其所連接之碳原子一起形成C3 -C6 環烷基，且R3 及R5 獨立地為氫或鹵素；或R6 係選自由以下組成之群：二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷-1,2-二氫茚]-1-基、苯基、萘基、與苯基稠合之4員至6員單環非芳族雜環、與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基、芳族5員或6員單環雜環、與芳基稠合之5員或6員單環芳族雜環、苯氧基、苯甲氧基或-OCF2 -苯基，其中R6 取代基之環狀或環狀部分可經一至三個選自由以下組成之群的R6S 取代基取代：氟、氯、氰基、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 烷氧基、C1 -C4 鹵烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C4 鹵烷基硫基、C3 -C6 環烷基、苯基、吡啶基、吡唑基、咪唑基、三唑基、氧雜環丁烷基及四氫呋喃基， 其中R6S 取代基之環狀或環狀部分可經一至三個獨立地選自由以下組成之群的取代基取代：氟、氯、C1 -C4 烷基、C1 -C4 鹵烷基及C1 -C4 烷氧羰基，R7 係選自由以下組成之群：氫、氯、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 羥基烷基、C1 -C4 烷基羰基、C1 -C4 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C3 -C6 環烷基、吡啶基、咪唑基、吡唑基、氧雜環丁烷基、四氫呋喃基、四氫哌喃基、吡咯啶基、氮雜環丁烷基及-N(Re )2 ， 其中Re 獨立地選自由以下組成之群：氫、C1 -C4 烷基及C3 -C6 環烷基， 其中脂族R7 及Re 取代基可經一或兩個獨立地選自由以下組成之群的R7Sa 取代基取代：C1 -C4 烷氧基、C3 -C6 環烷基、C1 -C2 烷氧羰基及苯基， 其中R7 之環狀或環狀部分及環狀Re 可經一或兩個獨立地選自由以下組成之群的R7Sc 取代基取代：氟、氯、羥基、C1 -C4 烷基及C1 -C4 烷氧基，R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C4 烷基硫基、C1 -C4 鹵烷基硫基、C1 -C4 烷基亞磺醯基、C1 -C4 烷基磺醯基、C3 -C6 環烷基、苯基、非芳族3員至7員雜環、芳族5員或6員雜環、非芳族3員至7員雜環基氧基及-N(Rh )2 ， 其中Rh 獨立地選自由以下組成之群：氫、C1 -C4 烷基、C2 -C6 烯基、C3 -C6 環烷基、苯基及非芳族3員至7員單環雜環， 其中脂族R8 及Rh 取代基可經一至三個獨立地選自由以下組成之群的R8Sa 取代基取代：羥基、羧基、C1 -C4 烷氧基、C1 -C4 烷氧基-C1 -C4 烷氧基、C1 -C4 烷氧羰基、C3 -C6 環烷基、非芳族3員至7員單環雜環及-N(Ra ' )2 ，其中Ra ' 獨立地選自由以下組成之群：氫、C1 -C4 烷基及C1 -C2 烷基羰基， 其中R8 之環狀或環狀部分及環狀Rh 取代基可經一至三個獨立地選自由以下組成之群的R8Sc 取代基取代：氯、氰基、羥基、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 烷氧基、C1 -C4 烷氧羰基、C3 -C6 環烷基、氧雜環戊基、氧雜環丁烷基及四氫呋喃基，或兩個R8Sc 取代基與其所連接之碳原子一起形成氧雜環丁烷基或環氧乙烷基，Q 係選自由以下組成之群：苯基、萘-2-基、雙環[4.2.0]辛-1(6),2,4-三烯基、二氫茚基、1,2,3,4-四氫萘基、茚基、二氫萘基、雙環[4.2.0]辛-1(6)2,4-三烯基、2,3-二氫苯并呋喃基、1,3-二氫異苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、2,3-二氫-1,4-苯并二氧雜環己烯基、[1,3]二氧雜環戊并[4,5-b]吡啶基、5,6,7,8-四氫喹啉基、6,7-二氫-5H-環戊[b]吡啶基、1,3-苯并二氧雜環戊烯基、2,3-二氫苯并呋喃基、吡咯基、呋喃基、噻吩基、咪唑基、三唑基、噁唑基、噻唑基、吡啶基、噠𠯤基及嘧啶基、吲哚基、苯并咪唑基、吲唑基、苯并呋喃基、苯并噻吩基、苯并噻唑基、苯并噁唑基、喹啉基、呋喃并[3,2-b]吡啶基、噻吩并[3,2-b]苯硫基及噻吩并[2,3-d]噻唑基， 其中該等碳環或雜環基中之任一者可經一至三個獨立地選自由以下組成之群的QS 取代基取代：鹵素、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 烷氧基、C1 -C4 鹵烷氧基、C2 -C4 烯基、C2 -C4 炔基、C1 -C4 烷基硫基、C1 -C4 鹵烷基硫基、C3 -C6 環烷基、環氧乙烷基、氧雜環丁烷基及-N(Rk )2 ， 其中Rk 為氫， 其中QS 取代基之環狀或環狀部分可經一或兩個獨立地選自由以下組成之群的RQs 取代基取代：氟及氯。
在一甚至更佳實施例中，根據本發明之化合物為式(I)之化合物，其中T 為OR1 為氫， 當存在時(亦即n=1)，R2 及R3 為氫，或R2 及R3 與其所連接之碳原子一起形成環丙基或環丁基， 當存在時(亦即m=1)，R4 及R5 獨立地選自由以下組成之群：氫及鹵素，R6 為二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷-1,2'-二氫茚]-1-基、2,3-二氫苯并呋喃基、1,3-苯并二氧雜環戊烯基、2,3-二氫-1,4-苯并二氧雜環己烯基、4,5,6,7-四氫苯并噻吩基、噻吩基、吡啶基、吲哚基、苯并噁唑基、喹啉基或異喹啉基， 其中該二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷-1,2'-二氫茚]-1-基、2,3-二氫苯并呋喃基、1,3-苯并二氧雜環戊烯基、2,3-二氫-1,4-苯并二氧雜環己烯基、4,5,6,7-四氫苯并噻吩基、噻吩基、吡啶基、吲哚基、苯并噁唑基、喹啉基或異喹啉基可經一至三個獨立地選自由以下組成之群的R6S 取代基取代:鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 炔基、環丙基，R7 為氫、鹵素、氰基、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 羥基烷基、C1 -C4 烷基羰基、C1 -C4 烷氧基、C2 -C6 烯基、C2 -C6 炔基或環丙基， 其中脂族R7 可經一或兩個R7Sa 取代基甲氧基取代R8 為氫、鹵素、C1 -C4 烷基、C1 -C4 烷氧基、C2 -C4 烯基、C1 -C4 烷基硫基、吡唑基、咪唑基、噻唑基、吡啶基或-N(Rh )2 ， 其中Rh 獨立地選自由以下組成之群：氫、C1 -C4 烷基及環丙基， 其中該等脂族R8 取代基可經一或兩個獨立地選自由以下組成之群的R8Sa 取代基取代：C1 -C4 鹵烷基、C1 -C4 烷氧基、C1 -C4 烷氧基C1 -C2 烷氧基、環丙基及環丁基， 其中該等環狀R8 取代基可經一或兩個獨立地選自由鹵素組成之群的R8Sc 取代基取代，Q 為苯基、噻吩基或吡啶基， 其中該苯基、噻吩基及吡啶基可經一至三個獨立地選自由以下組成之群的QS 取代基取代：鹵素、C1 -C4 烷基、C1 -C4 鹵烷基、C1 -C4 烷氧基、C1 -C4 鹵烷氧基、C2 -C4 烯基、C2 -C4 炔基、C1 -C4 烷基硫基、C1 -C4 鹵烷基硫基、環丙基、環丁基、環氧乙烷基及氧雜環丁烷基。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中n為0且m為1。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中n為0且m為0。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中n為1且m為1。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中如本文所描述之Q 經一或多個可相同或不同之如本文所描述之QS 取代基取代。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中如本文所描述之R6 經一或多個可相同或不同之如本文所描述之R6S 取代基取代。
在實施例2、3及4中，R1 可選自由以下組成之群：氫、羥基及-C(=O)(ORa1 )，其中Ra1 為氫原子、C1 -C6 烷基或C2 -C6 烯基。適合之R1 之非限制性實例包括揭示於表1之「R1 」行中的R1 基團中之任一者。較佳地R1 為氫。
在實施例2、3及4中，當存在時(亦即n=1)，R2 及R3 可獨立地選自由以下組成之群：氫、氰基、C1 -C6 烷基(例如甲基)及C1 -C6 烷氧羰基(例如甲氧基羰基)，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)。較佳地，當存在時，R2 及R3 均為氫，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)。
在實施例2、3及4中，當存在時(亦即m=1)，R4 及R5 可獨立地選自由以下組成之群：氫、鹵素、羥基及C1 -C6 烷基(例如甲基)，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)或非芳族3員至7員單環雜環(例如非芳族3員至7員飽和單環雜環，舉例而言氧雜環丁烷基)。較佳地，當存在時，R4 及R5 獨立地選自由以下組成之群：氫、鹵素(例如氟)及C1 -C6 烷基(例如甲基)，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)。
在實施例2、3及4中，當R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基時，R2 及R4 較佳形成環丙基且R3 及R5 獨立地為氫或鹵素(例如氟)。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中當n=1且m=1時，R2 及R3 均為氫或在均為C1 -C6 烷基(例如甲基)，或R2 為氫且R3 為C1 -C6 烷氧羰基(例如甲氧基羰基)，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)，及R4 及R5 均為氫或均為鹵素(例如氟)，或R4 為氫且R5 為C1 -C6 烷基(例如甲基)，或R4 為氫且R5 為鹵素(例如氟)，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)，或R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基(例如環丙基)，且R3 及R5 獨立地為氫或鹵素(例如氟)。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中當n=0且m=1時，R4 及R5 均為氫或均為C1 -C6 烷基(例如甲基)或R4 為氫且R5 為C1 -C6 烷基(例如甲基)，或R4 及R5 形成非芳族3員至7員單環雜環(例如非芳族3員至7員飽和單環雜環，舉例而言氧雜環丁烷基)。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中當n=0且m=0時，R6 係選自由以下組成之群：非芳族C3 -C12 碳環(較佳C7 -C12 雙環系統，更佳包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統)、非芳族3員至14員雜環(較佳包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環、或包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族雙環雜環)、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基，較佳地R6 係選自由以下組成之群：二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷-1,2'-二氫茚]-1-基、2,3-二氫苯并呋喃基、𠳭烷基、異𠳭烷基、硫𠳭烷基、5,6,7,8-四氫喹啉基、4,5,6,7-四氫苯并噻吩基、苯甲氧基及-OCF2 -苯基。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中當n=0且m=1時，R6 係選自由以下組成之群：非芳族C3 -C12 碳環(較佳C7 -C12 雙環系統，更佳包含與C3 -C8 環烷基稠合之芳基的C7 -C12 雙環系統)、芳族C6 -C14 碳環、非芳族3員至14員雜環(較佳包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環)、芳族5員至14員雜環(較佳地包含與芳基稠合之5員或6員單環芳族雜環的9員或10員芳族雙環雜環、或包含兩個稠合的5員或6員單環芳族雜環之9員或10員芳族雙環雜環)、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基，較佳地R6 係選自由以下組成之群：二氫茚基、1,2,3,4-四氫萘基、苯基、萘基、2,3-二氫苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、吲哚基、喹啉基、異喹啉基、咪唑并[1,2-a]吡啶基、苯氧基、苯甲氧基及-OCF2 -苯基。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中當n=1且m=1時，R6 係選自由以下組成之群：芳族C6 -C14 碳環、非芳族3員至14員雜環(較佳包含與芳基稠合之4員至6員單環非芳族雜環的非芳族雙環雜環)、芳族5員至14員雜環(較佳5員或6員單環芳族雜環或包含與芳基稠合之5員或6員單環芳族雜環的9員或10員芳族雙環雜環)、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基，較佳地R6 係選自由以下組成之群：苯基、2,3-二氫苯并呋喃基、1,3-苯并二氧雜環戊烯基、2,3-二氫-1,4-苯并二氧雜環己烯基、呋喃基、噻吩基、吡啶基、嘧啶基、苯并呋喃基、1,3-苯并噁唑基、苯氧基、苯甲氧基及-OCF2 -苯基。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中T 為O。
在一些實施例中，根據本發明之化合物為根據實施例1、2、3或4之式(I)之化合物，其中T 為S。
本發明亦關於表1中所揭示之任何式(I)之化合物。
式(I)之化合物可用作殺真菌劑(用於防治植物病原性真菌)，尤其在用於控制植物病原性真菌之方法中使用，該方法包含以下步驟：將一或多種式(I)之化合物施加於植物上。
用於製備式 ( I ) 之化合物及中間物之方法 本發明係關於用於製備式(I)之化合物及其中間物之方法。除非另外指示，否則基團Q 、T 、R1 、R2 、R3 、R4 、R5 、R6 、R7 、R8 、m 及n 具有以上針對式(I)之化合物所給出之含義。此等定義不僅應用於式(I)之最終產物，但亦應用於所有中間物。
式(I-a)-(I-g)之化合物為式(I)之各種子組。式(I-a-1)-(I-a-8)之化合物為式(I-a)之各種子組。除非另外說明，否則式(I-a)-(I-g)及(I-a-1)-(I-a-8)之所有取代基如上文針對式(I)所定義。
通式(I)之化合物可藉由類似於已知方法之各種途徑來製備(參見例如及其中之參考文獻)。本文中描述適合之方法的非限制性實例。
式(I)之化合物可直接藉由執行方法A或B獲得，或可藉由根據本文所述之方法製備之另一式(I)之化合物之轉化或衍生獲得。舉例而言，式(I)之化合物可藉由用其他取代基替代式(I)之起始化合物之一或多個取代基而轉化為另一式(I)之化合物。下文描述此類轉化或衍生之非限制性實例(方法C至H)。
可使用一或多種慣用於所考慮之反應之惰性有機溶劑適當地執行本文所描述之方法。適合之惰性有機溶劑可選自以下：脂族、脂環族或芳族烴(例如石油醚、戊烷、己烷、庚烷、環己烷、甲基環己烷、石油醚、苯、甲苯、二甲苯或十氫萘)、鹵化脂族、脂環族或芳族烴(例如氯苯、二氯苯、二氯甲烷、三氯甲烷、四氯化碳、1,2-二氯乙烷或三氯乙烷)、醚(例如乙醚、二異丙基醚、甲基第三丁基醚、甲基第三戊基醚、二噁烷、四氫呋喃、2-甲基四氫呋喃、1,2-二甲氧基乙烷、1,2-二乙氧基乙烷或苯甲醚)、酮(例如丙酮、甲基乙基酮、甲基異丙基酮及甲基異丁基酮)、酯(例如乙酸甲酯、乙酸乙酯或乙酸丁酯)、醇(例如甲醇、乙醇、丙醇、異丙醇、丁醇、第三丁醇)、腈(例如乙腈、丙腈、正丁腈或異丁腈或苯甲腈)、醯胺(例如N,N-二甲基甲醯胺、N,N-二甲基乙醯胺、N-甲基甲醯苯胺、N-甲基吡咯啶酮或六甲基磷醯三胺)、亞碸(例如二甲亞碸)或碸(例如環丁碸)、尿素(例如1,3-二甲基-3,4,5,6-四氫-2(1H)-嘧啶酮)或其任何混合物。
本文所描述之一些方法可能需要或任選地使用慣用於此類反應之一或多種無機或有機鹼執行。適合之無機及有機鹼之實例包括但不限於：鹼土金屬或鹼金屬碳酸鹽(例如碳酸鈉、碳酸鉀、碳酸氫鉀、碳酸氫鈉、或碳酸銫)；鹼金屬氫化物(例如氫化鈉)；鹼土金屬或鹼金屬氫氧化物(例如氫氧化鈉、氫氧化鈣、氫氧化鉀或其他氫氧化銨衍生物)；鹼土金屬、鹼金屬或氟化銨(例如氟化鉀、氟化銫或氟化四丁基銨)；鹼金屬或鹼土金屬乙酸鹽(例如乙酸鈉、乙酸鋰、乙酸鉀或乙酸鈣)；鹼金屬醇合物(例如第三丁醇鉀或第三丁醇鈉)；鹼金屬磷酸鹽(例如參-磷酸鉀)；三級胺(例如三甲胺、三乙胺、三丁胺、N,N-二甲基苯胺、N,N-二環己基甲胺、N,N-二異丙基乙胺、N-甲基哌啶、N,N-二甲胺基吡啶、二氮雜二環辛烷(DABCO)、二氮雜二環壬烯(DBN)或二氮雜雙環十一烯(DBU)、
Figure 108143210-A0304-12-01
啶、3-乙醯氧基
Figure 108143210-A0304-12-01
啶、胍或芳族鹼(例如吡啶、甲基吡啶、二甲基吡啶或三甲基吡啶)。
本文所描述之方法中之一些可視情況在過渡金屬催化劑(諸如金屬(例如銅或鈀)鹽或錯合物)存在下，視情況在配位體存在下執行。
適合之銅鹽或錯合物及其水合物包括但不限於：銅金屬、碘化亞銅(I)、氯化亞銅(I)、溴化亞銅(I)、氯化銅(II)、溴化銅(II)、氧化銅(II)、氧化亞銅(I)、乙酸銅(II)、乙酸亞銅(I)、噻吩-2-甲酸亞銅(I)、氰化亞銅(I)、硫酸銅(II)、雙(2,2,6,6-四甲基-3,5-庚二酮酸)銅、三氟甲烷磺酸銅(II)、六氟磷酸肆(乙腈)亞銅(I)、四氟硼酸肆(乙腈)亞銅(I)。
亦可藉由單獨添加鹽及配位體或鹽至反應物中產生反應混合物中當場適合之銅錯合物，該銅鹽及配位體或鹽諸如乙二胺、N,N-二甲基伸乙基二胺、N,N'-二甲基伸乙基二胺、rac -反-1,2-二胺基環己烷、rac - 反-N,N'-二甲基環己烷-1,2-二胺、1,1'-聯萘-2,2'-二胺、N,N,N',N'-四甲基乙二胺、脯胺酸、N,N-二甲基甘胺酸、喹啉-8-醇、吡啶、2-胺基吡啶、4-(二甲胺基)吡啶、2,2'-二吡啶基、2,6-二(2-吡啶基)吡啶、2-吡啶甲酸、2-(二甲胺基甲基)-3-羥基吡啶、1,10-啡啉、3,4,7,8-四甲基-1,10-啡啉、2,9-二甲基-1,10-啡啉、4,7-二甲氧基-1,10-啡啉、N,N'-雙[(E)-吡啶-2-基亞甲基]環己烷-1,2-二胺、N-[(E)-苯基亞甲基]、N-[(E)-苯基亞甲基]-環己胺、1,1,1-參(羥基甲基)乙烷、乙二醇、2,2,6,6-四甲基庚烷-3,5-二酮、2-(2,2-二甲基丙醯基)環己酮、乙醯基丙酮、二苯甲基甲烷、2-(2-甲基丙醯基)環己酮、聯二苯-2-基(二-第三丁基)膦、伸乙基雙-(二苯基膦)、N, N-二乙基水楊醯胺、2-羥基苯甲醛肟、側氧基[(2,4,6-三甲基苯基)胺基]乙酸或1H-吡咯-2-羧酸。
適合之鈀鹽或錯合物包括但不限於：氯化鈀、乙酸鈀、肆(三苯基膦)鈀(0)、雙(二苯亞甲基丙酮)鈀(0)、參(二苯亞甲基丙酮)二鈀(0)、雙(三苯基膦)二氯化鈀(II)、[1,1'-雙(二苯基膦基)二茂鐵]二氯化鈀(II)、雙(苯烯丙基)二氯化鈀(II)、雙(烯丙基)-二氯化鈀(II)或[1,1'-雙(二-第三丁基膦基)二茂鐵]二氯化鈀(II)。
亦有可能藉由向反應物中單獨添加諸如以下之鈀鹽及配體或鹽而在反應混合物中產生鈀錯合物：三乙基膦、三-第三丁基膦、四氟硼酸三-第三丁基鏻、三環己基膦、2-(二環已基膦基)聯二苯、2-(二-第三丁基膦)聯二苯、2-(二環已基膦基)-2'-(N,N-二甲胺基)聯二苯、2-(第三丁基膦)-2'-(N,N-二甲胺基)聯二苯、2-二-第三丁基膦-2',4',6'-三異丙基聯二苯、2-二環己基膦基-2',4',6'-三異丙基聯二苯、2-二環己基膦基-2,6'-二甲氧基聯二苯、2-二環己基膦基-2',6'-二異丙氧基聯二苯、聯三苯-膦、參-(鄰甲苯基)膦、3-(二苯膦基)苯磺酸鈉、參-(2-甲氧基-苯基)膦、2,2'-雙(二苯膦基)-1,1'-聯萘、1,4-雙(二苯膦基)丁烷、1,2-雙(二苯膦基)乙烷、1,4-雙(二環已基膦基)丁烷、1,2-雙(二環已基膦基)-乙烷、2-(二環已基膦基)-2'-(N,N-二甲胺基)-聯二苯、1,1'-雙(二苯膦基)-二茂鐵、(R)-(-)-1-[(S)-2-二苯膦基)二茂鐵基]乙基二環己基膦、參-(2,4-第三丁基-苯基)亞磷酸鹽、二(1-金剛烷基)-2-嗎啉基苯基膦或氯化1,3-雙(2,4,6-三甲基苯基)咪唑鎓。
可商業目錄(諸如Strem Chemicals之「Metal Catalysts for Organic Synthesis」)或綜述(Chemical Society Reviews (2014),43 , 3525; Coordination Chemistry Reviews (2004),248 , 2337及其中之參考文獻)選擇適當的催化劑及/或配位體。
本文所描述之方法中之一些可藉由根據文獻(Nature chemistry review,(2017) 0052及其中之參考文獻；Science (2016) 352, 6291, 1304; Org. Lett. 2016, 18, 4012, J. Org. Chem 2016, 81, 6898; J. Am. Chem. Soc. 2016, 138, 12715, J. Am. Chem. Soc. 2016, 138, 13862; J. Am. Chem. Soc. 2016, 138, 8034; J. Org. Chem. 2016, 81, 12525, J. Org. Chem. 2015, 80, 7642)中報導之方法的金屬光氧化還原催化來進行。隨後在感光劑(諸如Ir及Ru錯合物或有機染料)及金屬催化劑(諸如Ni錯合物)存在下進行該方法。可在配位體存在下且適當時在鹼存在下在藍光或白光照射下進行反應。
適合之光敏劑包括但不限於：Ir(III)光催化劑，諸如[Ir(dFCF3 ppy)2 (bpy)]PF6 (dFCF3 ppy = 2-(2,4-二氟苯基)-5-三氟甲基吡啶, bpy = 2,2'-聯吡啶)、[Ir(dFCF3 ppy)2 (dtbbpy)]PF6 (dtbbpy = 4,4'-二-第三丁基-2,2'聯吡啶)、Ir(ppy)2 (dtbbpy)PF6 (ppy = 2-苯基吡啶)、Ir(ppy)2 (bpy)PF6 、Ir(dFppy)3 PF6 (dFCF3 ppy = 2-(2,4-二氟苯基)吡啶)、fac -Ir(ppy)3 、(Ir[diF(5-Me)ppy]2 (四MePhen)PF6 (diF(5-Me)ppy = 2-(2,4-二氟苯基)-5-甲基吡啶、四MePhen = 3,4,7,8-四甲基-1,10-啡啉)、Ru(II)光催化劑，諸如Ru(bpy)3 Cl2 或Ru(bpy)3 (PF6 )2 或類似於9-
Figure 108143210-A0304-12-02
基-10-吖啶之有機染料、類似於過氯酸鹽或四氟硼酸之鹽、或2,4,5,6-四-9H -咔唑-9-基-1,3-苯二甲腈、9-茀酮及9,10-菲醌。
適合之鎳催化劑包括但不限於：在其無水或水合物形式下之雙(1,5-環辛二烯)鎳(0)、氯化鎳(II)、溴化鎳(II)、碘化鎳(II)或作為二甲氧基乙烷錯合物、乙醯基丙酮酸鎳(II)、硝酸鎳(II)六水合物。此等鎳催化劑可與以下組合使用：聯吡啶配位體，諸如2,2'-聯吡啶、4,4'-二-第三丁基-2,2'-聯吡啶、4,4'-二甲氧基-2,2'-聯吡啶、4,4'-二甲基-2,2'-聯吡啶或啡啉，諸如1,10-啡啉、4,7-二甲基-1,10-啡啉、4,7-二甲氧基-1,10-啡啉或二胺，諸如N,N,N',N'-四甲基乙二胺或二酮諸如四甲基庚二酮。
本文所描述之方法可在範圍介於-105℃至250℃、較佳-78℃至185℃之溫度下進行。
反應時間隨反應規模及反應溫度變化，但通常在幾分鐘與48小時之間。
本文所描述之方法一般在標準壓力下進行。然而，亦有可能在高壓或減壓下起作用。
在本文所描述之方法中，起始物質通常以大致等莫耳量使用。然而，亦有可能以相對較大過量使用起始物質中之一者。
用於製備式 ( I ) 之化合物之方法 方法 A 式(I-a)化合物(亦即式 ( I ) ， 其中 T 為 O 且 R1 為氫、羥基、氰基、 C1 - C6 烷基或 C1 - C6 烷氧基 )可藉由包含以下步驟之方法製備：使式(1)之化合物與式(2)之胺或其鹽反應，如流程1中所示。 流程1：方法A 合成式(I-a)之醯胺
Figure 02_image033
U1 =羥基、鹵素、C1 -C6 烷氧基R1 =氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，其中Ra1 及Ra2 與如本文所描述
其中U1 為羥基之式(1)之化合物可在縮合試劑存在下藉助於文獻(例如Tetrahedron 2005, 61, 10827-10852)中所描述之方法與式(2)之胺反應。適合之縮合試劑之實例包括但不限於鹵化試劑(例如光氣、三溴化磷、三氯化磷、五氯化二磷、三氯化磷、乙二醯氯或亞硫醯氯)、脫水試劑(例如氯甲酸乙酯、氯甲酸甲酯、氯甲酸異丙酯、氯甲酸異丁酯或甲磺醯氯)、碳二醯亞胺(例如N,N'-二環己基碳化二亞胺(DCC))或其他習用縮合(或肽耦合)試劑(例如五氧化二磷、聚磷酸、雙(2-側氧基-3-四氫噁唑基)次膦醯氯、1-[雙(二甲胺基)亞甲基]-1H-1,2,3-三唑并[4,5-b]吡啶鎓3-氧化六氟磷酸酯(HATU)、N,N'-羰基-二咪唑、2-乙氧基-N-乙氧羰基-1,2-二氫喹啉(EEDQ)、三苯膦/四氯-甲烷、4-(4,6-二甲氧基[1.3.5]-三𠯤-2-基)-4-氯化甲基嗎福啉鎓水合物、溴基-三吡咯烷基鏻六氟磷酸鹽或丙烷膦酸酐(T3P)。
其中U1 為鹵素原子之式(1)之化合物可在除酸劑存在下藉助於熟知方法與式(2)之胺反應。適合之除酸劑包括如本文所描述之任何無機鹼及有機鹼，其對於此類反應為慣用的。較佳為鹼金屬碳酸鹽、鹼土金屬乙酸鹽、三級胺或芳族鹼。
其中U1 為C1 -C6 烷氧基之式(1)之化合物可與過量式(2)之胺，視情況在路易斯酸(諸如三甲基鋁)存在下反應。
式(1)之化合物可藉由本文所描述之方法中之一或多者製備(參見方法I、方法J及方法K)。
式(2)之胺為可商購的或可根據文獻(例如WO2007141009、WO2013064460、WO2015078800、WO2016066574、US20060116370、WO2007134799、WO2014177487、WO2011144338、EP0807629)中所描述之方法製備。
方法 B 式(I-a-1)(亦即式 ( I ) ， 其中 T 為 O ， R1 為氫、氰基、羥基、 C1 - C6 烷基或 C1 - C6 烷氧基 ， R7 及 R8 如流程 2 中所定義 )之化合物可藉由包含以下步驟之方法製備：使式(3)之化合物與式(4)之化合物在如流程2中所示之鹼(例如有機鹼或無機鹼)存在下反應。 流程2：工藝B-合成醯胺(I-a-1)
Figure 02_image035
G =鹵素R1 =氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基R8 =氫、C1 -C6 烷基R7 =氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵基烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔氧基、C2 -C6 鹵炔氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基、-N(Re )2
在流程2中，Re 如本文所揭示且R7 、R8 及Re 可如本文所揭示經取代。
方法B可在過渡金屬催化劑(諸如銅鹽或錯合物)存在下，適當時在配位體存在下進行。
式(3)之化合物可藉由本文所描述之方法M製備。
式(4)之化合物為可商購的或可藉由根據熟知方法之另一式(4)之化合物的轉化或衍生作用來獲得。
方法 C 式(I-b)(亦即式 ( I ) ， 其中 T 為 S 且 R1 為氫 )之化合物可藉由包含以下步驟之方法製備：使式(I-a-2) (亦即式 ( I ) ， 其中 T 為 O 且 R1 為氫 )之化合物與如流程3中所示之硫化劑反應。
Figure 02_image037
用於進行方法C之適合的硫化劑包括但不限於硫(S)、硫酸(H2 S)、硫化鈉(Na2 S)、硫氫化鈉(NaHS)、三硫化硼(B2 S3 )、雙(二乙基鋁)硫化物((AlEt2 )2 S)、硫化銨((NH4 )2 S)、五硫化磷(P2 S5 )、勞森試劑(2,4-雙(4-甲氧基苯基)-1,2,3,4-二硫雜二磷雜環丁烷2,4-二硫化物)或描述於Journal of the Chemical Society, Perkin 1 (2001), 358中之聚合物負載的硫試劑。
該方法視情況在催化或化學計量或過量之鹼(無機鹼及有機鹼)存在下進行。較佳為鹼金屬碳酸鹽(例如碳酸鈉、碳酸鉀、碳酸氫鉀、碳酸氫鈉)、雜環芳族鹼(例如吡啶、甲基吡啶、二甲基吡啶、三甲基吡啶)、以及三級胺(例如三甲胺、三乙胺、三丁胺、N,N-二甲基苯胺、N,N-二甲基吡啶-4-胺或N-甲基-哌啶)。
式(I-a-2)之化合物可藉由本文所描述之方法中之一或多者製備。
方法 D 式(I-c)之化合物(亦即式 ( I ) ， 其中 R1 為 - C (= O ) Ra1 、 - C (= O )( ORa1 ) ， 其中 Ra1 如本文所描述 )可藉由包含以下步驟之方法製備：使式(I-a-2)(亦即式(I)，其中 T 為O且 R1 為氫)之化合物或式(I-b)(亦即式(I)，其中 T 為S 且 R1 為氫)之化合物與流程4中所示之式(5)之化合物反應。 流程4：方法D-合成醯胺或硫醯胺(I-c)
Figure 02_image039
W =鹵素、-O-(C=O)Ra1 或-O-C(=O)(ORa1 )，與其中Ra1 選自由以下組成之群：C1 -C6 烷基及C1 -C6 鹵烷基R1 = -C(=O)Ra1 及-C(=O)(ORa1 )，其中Ra1 及Ra2 如本文所描述
方法D可藉助於文獻(例如Tetrahedron Lett. 1995, 36, 8949; Greene's Protective Groups in organic Synthesis; Peter G. M. Wuts; Wiley; 第五版; 2014; 1174-1175)中所描述之方法進行。
式(5)之化合物為可商購的。
式(I-a-2)或(I-b)之化合物可藉由本文所描述之方法中之一或多者製備。
方法 E 式(I-a-3)(亦即式(I)，其中 R1 為H， T 為O， R7 為如流程5中所示之R7a )之化合物可藉助於文獻中描述之方法轉化成如流程5中所示之一或多個步驟中之相應化合物(I-a-4) (亦即式(I)，其中 R1 為H， T 為O， R7 為如流程5中所示之R7b )或(I-a-5) (亦即式(I)，其中 R1 為H ， T 為 O ， R7 為如流程5中所示之R7c )。
Figure 02_image041
R7a =氫或鹵素(較佳氯)R7b =氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 、-C(=O)(ORg )R7c =硝基、甲醯基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 羥烷基、C1 -C6 氟烷基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C3 -C8 環烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基磺醯基、-C(=NRf )Rf 、 -C(=O)N(Rg )2 、-S(=O)(=NRg )Rg 、-S(=O)2 N(Rg )2
在流程5中，Re 、Rf 、Rg 如本文所揭示且脂族及環狀取代基R7b 、R7c 、Re 、Rf 、Rg 可如本文所揭示經取代。
根據流程5進行之轉化之非限制性實例提供於下文中。
其中R7a 為氯原子之式(I-a-3)之化合物可藉助於文獻(例如WO2016185342、WO2007022937)中描述之方法轉化成其中R7b 為溴或碘原子之式(I-a-4)之化合物。
在如文獻(Journal of Molecular Catalysis A: Chemical, 2014, 393, 191-209)中報導之鈀催化劑存在下，其中R7a 為鹵素原子之式(I-a-3)化合物可轉化成其中R7b 為氫原子之式(I-a-4)之化合物。
其中R7a 為氫原子或鹵素原子之式(I-a-3)化合物可藉由如本文所描述之過渡金屬催化或金屬光氧化還原催化方法轉化成式(I-a-4)之化合物，其中R7b 為氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 或-C(=O)(ORg )。
可藉助於文獻(例如J. Org. Chem. 1993, 55, 3114)中所描述之方法，將其中R7b 為經C1 -C3 烷氧基取代之C2 -C6 烯基的式(I-a-4)之化合物轉化成其中R7c 為C1 -C6 -烷基羰基之式(I-a-5)之化合物。
其中R7c 為C1 -C6 烷基羰基之式(I-a-5)之化合物可藉由文獻(例如Greene's Protective Groups in organic Synthesis; Peter G. M. Wuts; Wiley; 第五版; 2014; 655, 661, 667)中描述之方法進一步轉化為其中R7c 為-C(=NRf )-C1 -C6 烷基之式(I-a-5)之化合物。
其中R7c 為C1 -C6 烷基羰基之式(I-a-5)之化合物可藉由經典官能基相互轉化(諸如在含NaBH4 之MeOH存在下將酮還原成醇)而進一步轉化為其中R7c 為C1 -C6 羥基烷基之式(I-a-5)化合物。
其中R7c 為C1 -C6 羥基烷基之式(I-a-5)之化合物可在氟化劑存在下進一步轉化成其中R7c 為C1 -C6 氟烷基之化合物(I-a-5)。氟化劑之非限制性實例包括氟化硫，諸如四氟化硫、三氟化二乙基胺基硫、三氟化(N-嗎啉基)硫、三氟化雙(2-甲氧基乙基)胺基硫、2,2-二氟-1,3-二甲基咪唑啶或三氟化4-第三丁基-2,6-二甲基苯基硫。
式(I-a-3)之化合物可藉由本文所描述之方法中之一或多者製備。
方法 F 式(I-a-6)之化合物(亦即式 ( I ) ， 其中 R1 為 H ， T 為 O ， R7 為鹵素且 R8 為氫 )可藉助於文獻中描述之方法轉化成相應的式(I-a-7)之化合物(亦即式 ( I ) ， 其中 R1 為 H ， T 為 O ， R7 為鹵素且 R8 為如流程 6 中所示之 R8a )或流程6中所示之一或多個步驟中之式(I-a-8)之化合物(亦即式 ( I ) ， 其中 R1 為 H ， T 為 O ， R7 為鹵素且 R8 為如流程 6 中所示之 R8b )。
Figure 02_image043
R7 =鹵素R8a =鹵素、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、5員至14員芳族雜環、3員至14員非芳族雜環；R8b =鹵素、氰基、硝基、胺基、巰基、羥基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C3 -C8 環烷基、C3 -C6 環烯基、芳族5員至14員雜環、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、非芳族3員至14員雜環基氧基、芳族5員至14員雜環基氧基、-N(Rh )2 、-SRi 、-S(=O)Ri 及-S(=O)2 Ri ；
在流程6中，Rh 及Ri 如本文所揭示且脂族及環狀取代基R8a 及R8b 可如本文所揭示經取代。
根據流程6進行之轉化之非限制性實例提供於下文中。
可藉助於文獻(例如Org.Lett. 2009, 11, 1837)中描述之方法將式(I-a-6)之化合物轉化成式(I-a-7)之化合物(其中R8a 為在鹼及諸如NCS、NBS、NIS、六氯乙烷、溴或碘之親電子劑存在下之鹵素原子)。用於進行該方法之適合的鹼可選自鋰-二異丙基醯胺、鋰2,2,6,6-四甲基哌啶、正丁基鋰、甲基鋰、TMPZnCl.LiCl(2,2,6,6-四甲基哌啶基氯化鋅氯化鋰錯合物)、TMP2 Zn·2MgCl2 ·2LiCl(雙(2,2,6,6-四甲基哌啶基)氯化鋅氯化鋰錯合物)，參見例如Dissertation Albrecht Metzer 2010, University Munich。
視情況在鹼存在下且在適當時在過渡金屬催化劑(諸如金屬鹽或錯合物及如本文所描述之配位體)存在下或藉由文獻(雜環1976, 4(8), 1331)中所描述之方法,式(I-a-6)之化合物可轉化為式(I-a-7)之化合物(其中R8a 為C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、5員至14員雜芳族雜環或3員至14員非芳族雜環)。
在鹼存在下且視情況在過渡金屬催化劑(諸如金屬鹽或錯合物)存在下，且在適當時在配位體存在下，式(I-a-7)之化合物(其中R8a 為鹵素原子)可轉化為式(I-a-8)之化合物(其中R8b 表示氰基、硝基、胺基、巰基、羥基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C3 -C8 環烷基、C3 -C6 環烯基、芳族5員至14員雜環、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、非芳族3員至14員雜環基氧基、芳族5員至14員雜環基氧基、-N(Rh )2 或SRi )。
藉由使式(I-a-8)之化合物與氧、硫或基於胺基之親核劑反應，式(I-a-8)之化合物(其中R8b 為C2 -C6 烯基)可進一步轉化為式(I-a-8)之化合物(其中R8b 為經C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、非芳族3員至7員單環雜環及-N(Ra ' )2 取代之C1 -C6 烷基，其中Ra ' 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基及C3 -C8 環烷基)。
藉由使式(I-a-8)之化合物之起始化合物與諸如過氧化氫之氧化劑反應，式(I-a-8)之化合物(其中R8b 為SRi 基團)可進一步轉化為式(I-a-8)之化合物(其中R8b 為-S(=O)Ri 或-S(=O)2 Ri 基團)。
式(I-a-6)之化合物可藉由本文所描述之方法中之一或多者製備。
方法 G 式(I-d)(亦即式 ( I ) ， 其中 R6S 為鹵素 )之化合物或式(6)之化合物可與式(7)之化合物反應以得到如流程7中所示之式(I-e)(亦即式 ( I ) ， 其中 R6S 如流程 7 中所示 )之化合物。 流程7：方法G-合成醯胺或硫醯胺(I-e)
Figure 02_image045
G1 =鹵素G2 =脫離基(例如O-S(=O)2 -C1 -C6 烷基或O-S(=O)2 芳基，例如三氟甲磺酸酯基、甲磺酸酯基或甲苯磺酸酯基)W =氫、鹵素、硼酸、硼酸酯衍生物或三氟硼酸鉀衍生物或-Sn(C1 -C6 烷基)3 、-MgX、-ZnX，其中X為鹵素R6S =氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C8 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環
在流程7中，脂族及環狀R6S 取代基可如本文所揭示經取代。
方法G可藉由如本文所描述之金屬催化進行。
或者，方法G可藉由金屬-光氧化還原催化進行。更具體言之，藉由金屬-光氧化還原催化方法在諸如Ir及Ru錯合物之感光劑或有機染料及諸如Ni錯合物之金屬催化劑存在下，式(I-d)之化合物(其中G1 較佳為Br或I)可轉化成式(I-e)之化合物。可在配位體存在下且適當時在鹼存在下在藍光或白光照射下進行反應。
式(I-d)之化合物可藉由本文所描述之方法中之一或多者製備。
式(6)之化合物可藉由熟知方法製備。
式(7)之化合物為可商購的。
方法 H 式(I-f)(亦即式 ( I ) ， 其中 QS 為鹵素 )之化合物或式8之化合物可與式9之化合物反應以得到如流程8中所示之式(I-g)(亦即式 ( I ) ， 其中 QS 如流程 8 中所示 )之化合物。
Figure 02_image047
G1 =鹵素G2 =脫離基，例如O-S(=O)2 -C1 -C6 -烷基或O-S(=O)2 芳基W =氫、鹵素、硼酸、硼酸酯衍生物或三氟硼酸鉀衍生物或-Sn(C1 -C6 烷基)3 、-MgX、-ZnX，其中X為鹵素QS =氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C3 -C8 環烷基、C3 -C6 環烯基、非芳族3員至7員單環雜環、芳族5員至6員雜環
在流程8中，脂族及環狀QS 取代基可如本文所揭示經取代。
方法H可藉由過渡金屬催化進行。
或者，方法H可藉由金屬-光氧化還原催化進行。更具體言之，藉由金屬-光氧化還原催化方法在諸如Ir及Ru錯合物之感光劑或有機染料及諸如Ni錯合物之金屬催化劑存在下，式(I-f)之化合物(其中G1 較佳為Br或I)可轉化成式(I-g)之化合物。可在配位體存在下且適當時在鹼存在下在藍光或白光照射下進行反應。
式(I-f)之化合物可藉由本文所描述之方法中之一或多者製備。
式(8)之化合物可藉由熟知方法製備。
式(9)之化合物為可商購的。
用於製備式 ( 1 ) 之化合物之方法 式(1)之化合物可直接藉由進行下文所描述之方法I獲得，或可藉由轉化或衍生根據本文所描述之方法製備之另一式(1)之化合物獲得。式(1-a)-(1-e)之化合物為式(1)之各種子組。
方法 I 式(1-a)之化合物(亦即式 ( 1 ) ， 其中 R7 及 R8 如流程 9 中所定義 )可藉由包含以下步驟之方法製備：使式(10)之化合物與如流程9中所示之式(4)之試劑在鹼存在下反應。 流程9：方法I-製備化合物(1-a)及(1-b)
Figure 02_image049
U1 =C1 -C6 烷氧基U2 =羥基、鹵素G =鹵素R8 =氫、C1 -C6 烷基R7 =氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔氧基、C2 -C6 鹵炔氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基、-N(Re )2
在流程9中，Re 如本文所揭示且R7 、R8 及Re 可如本文所揭示經取代。
方法I可在適合之過渡金屬催化劑鹽或錯合物存在下，適當時在配位體存在下進行。
隨後可在一或多個步驟中將所獲得之式(1-a)之化合物轉化成式(1-b)之化合物。
在下文描述此類轉化之非限制性實例。
藉由熟知官能基相互轉化方法，例如藉由將酯基與LiOH在THF/水中水解，式(1-a)之化合物(其中U1 為C1 -C6 烷氧基)可轉化為式(1-b)之化合物(其中U2 為羥基)。
藉由熟知方法在鹵化劑存在下，式(1-b)之化合物(其中U2 為羥基)可轉化為式(1-b)之化合物(其中U2 為鹵素)。適合之鹵化劑包括但不限於三溴化磷、三氯化磷、五氯化二磷、三氧化二磷、乙二醯氯或亞硫醯二氯。
式(10)之化合物為可商購的或可藉由本文所述之方法M製備。
式(4)之化合物為可商購的或可藉由根據熟知方法之另一式(4)之化合物的轉化或衍生作用來獲得。
方法 J 藉助於已知方法，式(1-c)之化合物(亦即式 ( 1 ) ， 其中 R7 為如流程 10 中所定義之 R7a )可轉化為如流程10中所示之一或多個步驟中之式(1-d)之相應化合物(亦即式 ( 1 ) ， 其中 R7 為如流程 10 中所定義之 R7b )或式(1-e)之相應化合物 (亦即式 ( 1 ) ， 其中 R7 為如流程 10 中所定義之 R7c )。
Figure 02_image051
U1 =C1 -C6 烷氧基R7a =氫或鹵素(較佳氯)R7b =氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 、-C(=O)(ORg )R7c =硝基、甲醯基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 羥烷基、C1 -C6 氟烷基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C3 -C8 環烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基磺醯基、-C(=NRf )Rf 、 -C(=O)N(Rg )2 、-S(=O)(=NRg )Rg 、-S(=O)2 N(Rg )2
在流程10中，Re 、Rf 、Rg 如本文所揭示且脂族及環狀取代基R7b 、R7c 、Re 、Rf 、Rg 可如本文所揭示經取代。
轉化之非限制性實例可根據方法E中所提供之描述來進行。
隨後所獲得之式(1-d)及(1-e)之化合物可轉化為式(1-d)及(1-e)之化合物(其中U1 (C1 -C6 烷氧基)經羥基或鹵素置換)。
在下文描述此類轉化之實例。
藉由熟知官能基相互轉化方法，例如藉由將酯基與LiOH在THF/水中水解，式(1-c)、(1-d)、(1-e)之化合物(其中U1 為C1 -C6 烷氧基)可轉化為式(1-b)、(1-c)、(1-d)之化合物(其中U1 經羥基置換)。
隨後藉由熟知方法在鹵化劑存在下，式(1-c)、(1-d)、(1-e)之化合物(其中U1 已經羥基置換)可進一步轉化為式(1-b)、(1-c)、(1-d)之化合物(其中羥基經鹵素置換)。適合之鹵化劑包括但不限於三溴化磷、三氯化磷、五氯化二磷、三氧化二磷、乙二醯氯或亞硫醯二氯。
式(1-c)之化合物可藉由本文所描述之方法中之一或多者製備。
方法 K 藉助於文獻中描述之方法，式(1-f)之化合物(亦即式 ( 1 ) ， 其中 R8 為 H )可轉化為如流程11中所示之一或多個步驟中之式(1-g)之化合物(亦即式 ( 1 ) ， 其中 R8 為如流程 11 中所定義之 Ra )或式(1-h)之化合物(亦即式 ( 1 ) ， 其中 R8 為如流程 11 中所定義之 R8b )。
Figure 02_image053
U1 =C1 -C6 烷氧基R8a =鹵素、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、5員至14員芳族雜環、3員至14員非芳族雜環；R8b =鹵素、氰基、硝基、胺基、巰基、羥基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C3 -C8 環烷基、C3 -C6 環烯基、芳族5員至14員雜環、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、非芳族3員至14員雜環基氧基、芳族5員至14員雜環基氧基、-N(Rh )2 、-SRi 、-S(=O)Ri 及-S(=O)2 Ri
在流程11中，Rh 及Ri 如本文所揭示且脂族及環狀取代基R8a 及R8b 可如本文所揭示經取代。
轉化之非限制性實例可根據方法F中所提供之描述來進行。
隨後所獲得之式(1-f)及(1-g)之化合物可轉化為式(1-f)及(1-g)之化合物(其中U1 (C1 -C6 烷氧基)經羥基或鹵素置換)。
藉由熟知官能基相互轉化方法，例如藉由將酯基與LiOH在THF/水中水解，式(1-f)、(1-g)、(1-h)之化合物(其中U1 為C1 -C6 烷氧基)可轉化為式(1-f)、(1-g)、(1-h)之化合物(其中U1 經羥基置換)。
隨後藉由熟知方法在鹵化劑存在下，式(1-f)、(1-g)、(1-h)之化合物(其中U1 已經羥基置換)可進一步轉化為式(1-f)、(1-g)、(1-h)之化合物(其中羥基經鹵素置換)。適合之鹵化劑包括但不限於三溴化磷、三氯化磷、五氯化二磷、三氧化二磷、乙二醯氯或亞硫醯二氯。
式(1-f)之化合物可藉由本文所描述之方法中之一或多者製備。
用於製備式 ( 3 ) 之化合物之方法 方法 L 式(3)之化合物可藉由包含以下步驟之方法製備：使式(10)之化合物與如流程13中所示之式(2)之胺反應。 流程12：方法L-合成醯胺(3)
Figure 02_image055
U1 =羥基、鹵素、C1 -C6 烷氧基G =鹵素R1 =氫、羥基、C1 -C6 烷基、C1 -C6 烷氧基R8 =氫、C1 -C6 烷基R7 =氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔氧基、C2 -C6 鹵炔氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基、-N(Re )2 ；其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代。
可使用與方法A中所描述相同之條件進行方法L。
式(10)之化合物為可商購的或可藉由方法M獲得。
用於製備式 ( 10 ) 之化合物之方法 方法 M 在基於氧(乙醇)、硫(硫基乙基)或胺基(甲胺)之親核劑存在下，視情況在如流程13中所示之鹼存在下，式(10-a)之化合物(亦即式10之化合物，其中R7 為鹵素)可藉助於已知方法(WO2000044755)轉化為式(10-b)之化合物(亦即式10之化合物，其中R7 如流程13中所示)。 流程13：方法M-製備化合物(10-b)
Figure 02_image057
U1 =C1 -C6 烷氧基G =鹵素R8 =氫、C1 -C6 烷基R7 =鹵素、羥基、巰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔氧基、C2 -C6 鹵炔氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基、-N(Re )2 ；其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代。
使用與方法K中所描述相同之條件，式(10-a)及(10-b)之化合物可轉化為式(10-a)及(10-b)之化合物，其中U1 (C1 -C6 烷氧基)經羥基或鹵素置換。
式(10-a)之起始材料為可商購的。
根據本發明之化合物可根據上文所描述之方法製備。儘管如此，應理解，基於其常識及可用之公開案，熟習此項技術者將能夠根據需要合成之根據本發明化合物中之每一者的特殊性來調整此等方法。
用於製備式 ( I ) 之化合物之中間物 本發明亦關於用於製備式(I)之化合物的中間物。
根據本發明之中間物為式(1)之化合物：
Figure 02_image059
其中Q 如本文所描述；U1 表示羥基、鹵素、C1 -C6 烷氧基；R7 、R8 如本文所描述且不同時表示氫、C1 -C6 烷基及芳族C6 -C14 碳環； 其限制條件為式(1)之化合物不為：
 6-氯-3-(2,4-二氟苯氧基)嗒𠯤-4-甲酸甲酯 1007571-73-4
6-氯-3-[(8-甲醯基-4-甲基-2-側氧基-2H-苯并哌喃-7-基)氧基]嗒𠯤-4-甲酸 953070-74-1
6-氯-3-[(3-甲醯基-7-甲基喹啉-2-基)氧基]嗒𠯤-4-甲酸 953070-59-2
 6-氯-3-{[4-甲醯基-5-(羥基甲基)-2-甲基吡啶-3-基]氧基}嗒𠯤-4-甲酸 953070-45-6
 6-氯-3-[(1-甲醯基-2-萘基)氧基]嗒𠯤-4-甲酸 953070-36-5
6-氯-3-(2-甲醯基-5-甲氧基苯氧基)嗒𠯤-4-甲酸 953070-24-1
 3-苯氧基-6-苯基嗒𠯤-4-甲酸乙酯 338752-99-1
根據本發明之中間物為式(3)之化合物：
Figure 02_image061
其中G 為鹵素，n =1且m =1，R1 為氫R2 、R3 為氫R4 及R5 為氫或氟；R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環、芳族C6 -C14 碳環(苯基)及非芳族6員至14員多環雜環，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代，R8 為氫或C1 -C6 烷基， 其限制條件為式(3)之化合物不為(r4 r5均為氫)
3,6-二氯-N-[2-(3,5-二氟苯基)乙基]嗒𠯤-4-甲醯胺 1963486-79-4
3,6-二氯-N-[2-(3-甲基苯基)乙基]嗒𠯤-4-甲醯胺 1963267-34-6
3,6-二氯-N-[2-(3-氯苯基)乙基]嗒𠯤-4-甲醯胺 1961466-79-4
3,6-二氯-N-[2-(4-氟-2-甲基苯基)乙基]嗒𠯤-4-甲醯胺 1958752-63-0
3,6-二氯-N-[2-(3-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 1939713-84-4
3,6-二氯-N-[2-(2-甲基苯基)乙基]嗒𠯤-4-甲醯胺 1931068-89-1
3,6-二氯-N-[2-(4-羥基苯基)乙基]嗒𠯤-4-甲醯胺 1930978-66-7
3,6-二氯-N-[2-(3-氟苯基)乙基]嗒𠯤-4-甲醯胺 1930464-33-7
3,6-二氯-N-[2-(2-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 1926106-33-3
3,6-二氯-N-[2-(4-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 1917672-49-1
3,6-二氯-N-[2-(4-氟苯基)乙基]嗒𠯤-4-甲醯胺 1916146-17-2
3,6-二氯-N-[2-(2,4-二氯苯基)乙基]嗒𠯤-4-甲醯胺 1912316-22-3
3,6-二氯-N-[2-(2-氟苯基)乙基]嗒𠯤-4-甲醯胺 1911438-43-1
3,6-二氯-N-(2-苯基乙基)嗒𠯤-4-甲醯胺 199478-02-9
其他中間物為式(3)之化合物：
Figure 02_image063
其中G 為鹵素，n =0且m =0，R1 為氫、羥基、C1 -C6 烷基或C1 -C6 烷氧基，R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環及及非芳族7員至14員多環雜環，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代，R8 為氫或C1 -C6 烷基， 其限制條件為式(3)之化合物不為
3,6-二氯-N-[(1R,2S)-2-羥基-2,3-二氫-1H-茚-1-基]嗒𠯤-4-甲醯胺 1971154-81-0
3,6-二氯-N-(3,4-二氫-2H-硫𠳭烯-4-基)嗒𠯤-4-甲醯胺 1963331-87-4
3,6-二氯-N-(2,3-二氫-1-苯并呋喃-3-基)嗒𠯤-4-甲醯胺 1961467-92-4
3,6-二氯-N-(4,5,6,7-四氫-1-苯并噻吩-4-基)嗒𠯤-4-甲醯胺 1942812-74-9
3,6-二氯-N-(2,3-二氫-1H-茚-1-基)嗒𠯤-4-甲醯胺 1942811-70-2
3,6-二氯-N-(1,2,3,4-四氫萘-2-基)嗒𠯤-4-甲醯胺 1930978-86-1
3,6-二氯-N-(4,5,6,7-四氫-1-苯并呋喃-4-基)嗒𠯤-4-甲醯胺 1927604-75-8
3,6-二氯-N-(3,4-二氫-2H-𠳭烯-4-基)嗒𠯤-4-甲醯胺 1912470-99-5
3,6-二氯-N-(1,2,3,4-四氫萘-1-基)嗒𠯤-4-甲醯胺 1912469-89-6
3,6-二氯-N-(1H-吲唑-3-基)嗒𠯤-4-甲醯胺 1482112-42-4
3,6-二氯-N-(2-羥基-2,3-二氫-1H-茚-1-基)嗒𠯤-4-甲醯胺 1293136-37-4
3,6-二氯-N-(4-甲基環庚基)嗒𠯤-4-甲醯胺 1991622-18-4
3,6-二氯-N-(2-甲基環庚基)嗒𠯤-4-甲醯胺 1963487-84-4
3,6-二氯-N-(9-甲基-9-氮雜雙環[3.3.1]壬-3-基)嗒𠯤-4-甲醯胺 1963487-78-6
3,6-二氯-N-(1-甲基-4,5,6,7-四氫-1H-吲唑-4-基)嗒𠯤-4-甲醯胺 1963485-29-1
 N-(1-苯并噻吩-5-基)-3,6-二氯嗒𠯤-4-甲醯胺 1963485-06-4
3,6-二氯-N-(1H-吲唑-7-基)嗒𠯤-4-甲醯胺 1963332-46-8
3,6-二氯-N-(1,3,3-三甲基雙環[2.2.1]庚-2-基)嗒𠯤-4-甲醯胺 1963268-26-9
3,6-二氯-N-(1H-吲哚-5-基)嗒𠯤-4-甲醯胺 1963266-43-4
3,6-二氯-N-(1,7,7-三甲基雙環[2.2.1]庚-2-基)嗒𠯤-4-甲醯胺 1961466-74-9
3,6-二氯-N-環庚基-N-甲基嗒𠯤-4-甲醯胺 1961466-15-8
3,6-二氯-N-(5,6,7,8-四氫萘-1-基)嗒𠯤-4-甲醯胺 1961465-77-9
3,6-二氯-N-(八氫-1H-4,7-甲醇茚-5-基)嗒𠯤-4-甲醯胺 1958753-78-0
3,6-二氯-N-(三環[3.3.1.13,7 ]癸-2-基)嗒𠯤-4-甲醯胺 1942811-90-6
3,6-二氯-N-(1-氰基環辛基)嗒𠯤-4-甲醯胺 1939855-37-4
3,6-二氯-N-(2,3-二氫-1H-茚-2-基)嗒𠯤-4-甲醯胺 1939855-34-1
 N-(雙環[2.2.1]庚-2-基)-3,6-二氯嗒𠯤-4-甲醯胺 1931071-17-8
3,6-二氯-N-(三環[3.2.1.02,4 ]辛-3-基)嗒𠯤-4-甲醯胺 1927867-21-7
3,6-二氯-N-(1-氰基環庚基)嗒𠯤-4-甲醯胺 1927604-66-7
3,6-二氯-N-(2,3-二氫-1H-茚-1-基)-N-甲基嗒𠯤-4-甲醯胺 1927604-33-8
3,6-二氯-N-(2-羥基環庚基)嗒𠯤-4-甲醯胺 1920574-97-5
3,6-二氯-N-(2,3-二氫-1H-茚-5-基)嗒𠯤-4-甲醯胺 1916145-93-1
3,6-二氯-N-(三環[3.3.1.13,7 ]癸-1-基)嗒𠯤-4-甲醯胺 1915386-75-2
3,6-二氯-N-環辛基嗒𠯤-4-甲醯胺 1912469-87-4
3-{[(3, 6-二氯嗒𠯤-4-基)羰基]胺基}雙環[2.2.1]庚烷-2-甲酸 1562074-06-9
2-{[(3,6-二氯嗒𠯤-4-基)羰基]胺基}環庚烷甲酸 1509304-68-0
3,6-二氯-N-(2,3-二氫-1-苯并呋喃-5-基)嗒𠯤-4-甲醯胺 1961467-28-6
3,6-二氯-N-(八氫吲哚嗪-1-基)嗒𠯤-4-甲醯胺 1961467-09-3
3,6-二氯-N-(3-氰基-5,6-二氫-4H-環戊[b]噻吩-2-基)嗒𠯤-4-甲醯胺 1939278-48-4
3,6-二氯-N-(八氫吲哚嗪-7-基)嗒𠯤-4-甲醯胺 1930979-01-3
3,6-二氯-N-(六氫-1H-吡
Figure 108143210-A0304-12-03
-1-基)嗒𠯤-4-甲醯胺		 1930978-29-2
3,6-二氯-N-(6-氯-1,3-苯并二氧雜環戊烯-5-基)嗒𠯤-4-甲醯胺 1930464-71-3
3,6-二氯-N-(5,6-二氫-4H-環戊[d][1,3]噻唑-2-基)嗒𠯤-4-甲醯胺 1927604-87-2
3,6-二氯-N-(2-側氧基氮雜環庚烷-3-基)嗒𠯤-4-甲醯胺 1924934-65-5
3,6-二氯-N-(4,5,6,7-四氫-1,3-苯并噻唑-2-基)嗒𠯤-4-甲醯胺 1916206-93-3
3,6-二氯-N-(2,3-二氫-1,4-苯并二氧雜環己烯-6-基)嗒𠯤-4-甲醯胺 1912468-93-9
N-(1,3-苯并二氧雜環戊烯-5-基)-3,6-二氯嗒𠯤-4-甲醯胺 1912468-90-6
3,6-二氯-N-(1-羥基-1,3-二氫-2,1-苯并噁硼-6-基))嗒𠯤基-4-甲醯胺 1222509-88-7
其他中間物為式(3)之化合物：
Figure 02_image065
其中G 為鹵素，n =0且m =1，R1 為氫、羥基、C1 -C6 烷基或C1 -C6 烷氧基R4 及R5 如本文所描述，R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環、芳族C6 -C14 碳環(苯基)、芳族5員至14員雜環及非芳族6員至14員多環雜環，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代，R8 為氫或C1 -C6 烷基， 其限制條件為式(3)之化合物不為
3,6-二氯-N-(2-氟基苯甲基)嗒𠯤-4-甲醯胺 N-(2-溴苯甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-羥基-2-苯基丙-2-基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[4-(羥基甲基)苯甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(嘧啶-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-甲基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-硝基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(吡啶-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氟基-3,5-二甲基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-苯基丙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2-甲基嘧啶-4-基)甲基]嗒𠯤-4-甲醯胺 N-[2-(4-溴苯基)丙-2-基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(3,4-二氟基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-甲基-1-苯基丙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[氰基(苯基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(6-甲氧基吡啶-3-基)甲基]嗒𠯤-4-甲醯胺 N-[1-(2-溴苯基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氰基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-異丙基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[3-(甲氧基甲基)苯甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-苯基丁基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2-甲氧基吡啶-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氟基苯甲基)嗒𠯤-4-甲醯胺 N-[1-(3-溴苯基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-羥基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-甲基苯基)丙基]嗒𠯤-4-甲醯胺 N-[1-(4-溴苯基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-甲基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(甲氧基甲基)苯甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-乙基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氯-4-氟基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(6-甲基吡啶-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,5-二甲基苯基)乙基]嗒𠯤-4-甲醯胺 N-[1-(4-溴苯基)丙基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-羥基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,6-二氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(吡啶-4-基)乙基]嗒𠯤-4-甲醯胺 N-(4-溴苯甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-乙氧基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-乙基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-甲基吡啶-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(嗒𠯤-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2-甲氧基吡啶-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-甲基吡啶-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-硝基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[4-(二甲基胺基)苯甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-氟基-4-甲基苯基)乙基]嗒𠯤-4-甲醯胺 N-[1-(4-溴苯基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4-甲基吡啶-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-硝基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氟基-4-甲基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-氯苯基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,4-二甲基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-甲基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氰基-2-氟基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-乙基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2,5-二氟基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2,4-二氟基苯甲基)嗒𠯤-4-甲醯胺 N-[1-(4-溴苯基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺 N-(5-溴-2-氟基苯甲基)-3,6-二氯嗒𠯤-4-甲醯胺 N-(2-溴-5-氟基苯甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-{1-[4-(甲基硫基)苯基]乙基}嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,5-二氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-氰基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-氯-6-甲氧基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-羥基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-乙基吡啶-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 N-(3-溴苯甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-甲基吡嗪-2-基)甲基]嗒𠯤-4-甲醯胺 N-(1,3-苯并間二氧雜環戊烯-4-基甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3,4-二氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-氯苯基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[環丙基(苯基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氰基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(吡啶-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(吡啶-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-甲基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3,4-二氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-甲氧基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氯苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-甲氧基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-氯苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氯苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-甲基苯甲基)嗒𠯤-4-甲醯胺 N-(1,3-苯并間二氧雜環戊烯-5-基甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,4-二氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-甲氧基苯甲基)嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯嗒𠯤-4-甲醯胺 5-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)吡啶-2-羧酸 2-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)異菸酸 3,6-二氯-N-[3-(羥基甲基)苯甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3,4-二甲氧基苯甲基)嗒𠯤-4-甲醯胺 3-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)苯甲酸 4-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)苯甲酸 3,6-二氯-N-[1-(2,4-二氟基苯基)乙基]嗒𠯤-4-甲醯胺 N-苯甲基-3-氯-6-(吡啶-4-基)嗒𠯤-4-甲醯胺 3-氯-6-(3-氯吡啶-4-基)-N-(2,4-二氯苯甲基)嗒𠯤-4-甲醯胺 3-氯-N-(2,4-二氯苯甲基)-6-(吡啶-4-基)嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-甲氧基嗒𠯤-4-甲醯胺 3-氯-6-甲氧基-N-(三環[3.3.1.13,7 ]癸-1-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氟基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-苯基乙基)嗒𠯤-4-甲醯胺 N-(雙環[2.2.1]庚-2-基甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氯苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(3-甲基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氟基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-氯苯基)乙基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-氯苯甲基)-N-乙基嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氰基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-甲氧基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(3,5-二氯苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(2,3-二氯苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-氯苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(2,4-二氟基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氯苯甲基)-N-乙基嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-氟基苯基)乙基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(2,4-二甲基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氰基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 N-(3-胺甲醯基苯甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[1-(4-甲基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3,4-二氟基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1RS)-2-羥基-1-苯基乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-氟基苯基)乙基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-羥基苯基)乙基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-羥基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 N-(雙環[4.2.0]辛-1,3,5-三烯-7-基甲基)-3,6-二氯嗒𠯤-4-甲醯胺 N-(3-溴苯甲基)-3,6-二氯-N-甲基嗒𠯤-4-甲醯胺 N-(4-溴苯甲基)-3,6-二氯-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(4-甲基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-氯苯基)乙基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-氯苯基)乙基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-甲氧基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 N-(2-溴苯甲基)-3,6-二氯-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-羥基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(4-乙基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(1-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-(3-甲基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-羥基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1RS)-2-羥基-1-苯基乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[4-(甲基硫基)苯甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-氟基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-氯-6-氟基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-(3-氟基苯甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2,4-二氯苯甲基)-N-甲基嗒𠯤-4-甲醯胺 N-[1-(雙環[2.2.1]庚-2-基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-甲氧基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(3,4-二氯苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-氯苯甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(吡啶-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(6-甲基吡啶-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-氟基苯甲基)-N-甲基嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-丙基嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-甲基嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-(2,2,2-三氟基乙基)嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-乙基嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-異丙基嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-(2-甲氧基乙基)嗒𠯤-4-甲醯胺 N-苯甲基-N-第二-丁基-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-羥基-1-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-羥基環庚基甲基]嗒𠯤-4-甲醯胺 N-苯甲基-3,6-二氯-N-(2-羥基乙基)嗒𠯤-4-甲醯胺 (2RS)-{[(3,6-二氯嗒𠯤-4-基)羰基]胺基}(苯基)乙酸 {[(3,6-二氯嗒𠯤-4-基)羰基]胺基}(苯基)乙酸 3-氯-6-(3-氯-5-甲基苯基)-N-(3,4-二甲氧基苯甲基)嗒𠯤-4-甲醯胺 3-氯-N-(3,4-二甲氧基苯甲基)-6-(3,5-二甲基苯基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(6,7-二氫-5H-吡咯并[2,1-c][1,2,4]三唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(5,6-二氫-4H-環戊并[b]噻吩-2-基甲基)嗒𠯤-4-甲醯胺 N-(1H-苯并咪唑-2-基甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,2-噻唑-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,2,3-噻二唑-5-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,3-噁唑-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,2,3-噻二唑-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,2-噻唑-5-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1H-1,2,3-三唑-5-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4,5-二甲基-2-噻吩基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1,3-噻唑-2-基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1H吡咯并-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2-甲基-1,3-噻唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4-甲基-1,3-噻唑-5-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-甲基-2-呋喃基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-乙基-2-噻吩基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-乙基-1,3-噻唑-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-氯-2-噻吩基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-噻吩基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2-甲基-1,3-噻唑-5-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-甲基-1,2,4-噁二唑-5-基)甲基]嗒𠯤-4-甲醯胺 N-[(5-溴-2-噻吩基)甲基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(5-氯-2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-甲基-2-噻吩基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4-甲基-1,3-噻唑-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(5-甲基-1,3-噻唑-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-甲基-1,2-噁唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,5-二甲基-3-呋喃基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(5-甲基-2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-呋喃基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3,5-二甲基-1,2-噁唑-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(5-乙基-1,3-噻唑-2-基)乙基]嗒𠯤-4-甲醯胺 N-[(3-溴-2-噻吩基)甲基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4-甲基-3-噻吩基)甲基]嗒𠯤-4-甲醯胺 N-[(4-溴-2-噻吩基)甲基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(5-甲基-2-呋喃基)乙基]嗒𠯤-4-甲醯胺 N-(1,3-苯并噻唑-2-基甲基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-噻吩基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1,3-噻唑-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,3-噻唑-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-甲基-1,2,4-噁二唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1H-吡唑-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,2,4-噁二唑-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-乙基-2-噻吩基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4,5-二甲基-1,3-噁唑-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2-側氧基-2,3-二氫-1,3-噻唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,2-噁唑-5-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,3-噻唑-5-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-噻吩基)丁基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,4-二甲基-1,3-噻唑-5-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1,3-噻唑-2-基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-乙基-1,3-噁唑-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(5-甲基-1,3-噁唑-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-甲基-1,3-噁唑-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4H-1,2,4-三唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-甲基-1,3-噻唑-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,3-噻唑-2-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-甲基-2-噻吩基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3,5-二甲基-1,2-噁唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-甲基-1,3-噻唑-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1,2-噁唑-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-甲基-1,2-噁唑-5-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2,5-二甲基-3-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-呋喃基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-呋喃基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-噻吩基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1H-咪唑-2-基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1H-咪唑-2-基)乙基]嗒𠯤-4-甲醯胺 5-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)-2-糠酸 2-(1-{[(3,6-二氯嗒𠯤-4-基)羰基]胺基}乙基)-1,3-噻唑-4-羧酸 2-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)-1,3-噻唑-4-羧酸 2-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)-4-甲基-1,3-噻唑-5-羧酸 3,6-二氯-N-(1H-咪唑-5-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1H-咪唑-2-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1H-吡唑-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1H-四唑-5-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1H-四唑-5-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(4H-1,2,4-三唑-3-基甲基)嗒𠯤-4-甲醯胺 5-({[(3,6-二氯嗒𠯤-4-基)羰基]胺基}甲基)-2-甲基-3-糠酸 3,6-二氯-N-(1H-吡唑-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-甲基-1H-吡唑-4-基)甲基]嗒𠯤-4-甲醯胺 N-[(1-苯甲基-1H-吡唑-4-基)甲基]-3,6-二氯嗒𠯤-4-甲醯胺 N-[(1-苯甲基-1H-吡唑-3-基)甲基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-甲基-1H-吡唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(1-甲基-1H-吡唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1-甲基-1H-吡唑-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(2-甲基-1,3-噻唑-5-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-甲基-1H-吡唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(3-甲基-2-噻吩基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(5-甲基-2-呋喃基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(吡啶-2-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-甲基-1H-吡咯-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1,5-二甲基-1H-吡唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(2-甲基-1,3-噻唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(5-甲基-1,2-噁唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(2-甲基-3-呋喃基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-甲基-1H-吡唑-5-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-甲基-4H-1,2,4-三唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(3-噻吩基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-甲基-1H-吡咯-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(4-甲基-1,3-噻唑-5-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(1,3-噻唑-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1,3-二甲基-1H-吡唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3,5-二甲基-1,2-噁唑-4-基)甲基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-異丙基-N-[(5-甲基-2-呋喃基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-氰基乙基)-N-(2-呋喃基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(3-乙基-1-甲基-1H-吡唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(6-甲基吡啶-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(1-甲基-1H-咪唑-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(吡啶-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-呋喃基甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-甲基-1H-1,2,4-三唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[1-(吡啶-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(吡啶-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(六氫-1H-吡咯并[2,1-c][1,4]噁嗪-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2,3-二氫-1-苯并呋喃-2-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-異丙基-N-(吡啶-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-(吡啶-2-基甲基)嗒𠯤-4-甲醯胺 N-[(5-溴-3-噻吩基)甲基]-3,6-二氯-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-異丙基-N-(2-噻吩基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(8-甲基-8-氮雜雙環[3.2.1]辛-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-(2-呋喃基甲基)嗒𠯤-4-甲醯胺 3-{[(3,6-二氯嗒𠯤-4-基)羰基]胺基}-3-(2-噻吩基)丙炔酸 3,6-二氯-N-[1-(1,5-二甲基-1H-吡唑-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-氯-2-噻吩基)甲基]-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4-甲基-4H-1,2,4-三唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-(吡啶-4-基甲基)嗒𠯤-4-甲醯胺 N-[(5-溴-2-呋喃基)甲基]-3,6-二氯-N-甲基嗒𠯤-4-甲醯胺 N-[(5-溴-2-噻吩基)甲基]-3,6-二氯-N-乙基嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-(2-噻吩基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(3-呋喃基甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1,3,5-三甲基-1H-吡唑-4-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(1-甲基-1H-咪唑-2-基)甲基]嗒𠯤-4-甲醯胺 N-[(4-溴-2-噻吩基)甲基]-3,6-二氯-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(2-噻吩基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-異丙基-N-(吡啶-2-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-甲基-1-(2-噻吩基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-[(6-甲基吡啶-2-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-([1,2,4]三唑[4,3-a]吡啶-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[1-(5-甲基-2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[1-(2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(6,7-二氫-5H-吡咯并[2,1-c][1,2,4]三唑-3-基甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-[(5-氯-2-噻吩基)甲基]-N-乙基嗒𠯤-4-甲醯胺 3,6-二氯-N-[(4-乙基-4H-1,2,4-三唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[(5-甲基-4H-1,2,4-三唑-3-基)甲基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1H-咪唑-2-基甲基)-N-甲基嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(1H-吡唑-4-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(4H-1,2,4-三唑-3-基甲基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(吡啶-2-基甲基)嗒𠯤-4-甲醯胺 1984430-44-5 1983343-88-9 1980402-62-7 1965966-39-5 1963833-87-5 1963492-55-8 1963492-48-9 1963491-81-7 1963488-67-6 1963486-64-7 1963485-86-0 1963484-73-2 1963333-54-1 1963333-42-7 1963331-49-8 1963297-88-2 1963294-35-0 1963293-42-6 1963292-84-3 1963269-92-2 1963266-87-6 1963266-33-2 1963265-38-4 1963249-29-7 1963249-05-9 1963248-27-2 1963243-46-0 1962808-22-5 1961468-92-7 1961467-12-8 1958785-37-9 1958753-51-9 1958753-47-3 1942813-14-0 1942812-70-5 1942812-67-0 1942812-44-3 1942812-03-4 1942811-84-8 1942811-75-7 1933878-63-7 1933878-55-7 1931659-50-5 1931658-85-3 1931658-71-7 1931658-38-6 1931071-02-1 1931070-99-3 1931070-97-1 1931070-94-8 1931070-86-8 1931070-68-6 1931068-96-0 1930979-34-2 1930979-21-7 1930978-85-0 1930978-62-3 1930978-34-9 1930978-16-7 1930978-15-6 1930466-03-7 1930465-94-3 1930465-46-5 1930465-19-2 1930465-11-4 1930465-08-9 1930464-96-2 1930464-73-5 1930464-69-9 1930464-55-3 1930464-37-1 1927605-30-8 1927605-28-4 1927605-21-7 1927605-04-6 1927604-80-5 1927604-79-2 1927604-68-9 1927604-65-6 1927604-38-3 1927604-28-1 1927604-27-0 1927604-26-9 1927604-18-9 1927604-09-8 1927604-08-7 1919457-44-5 1919457-31-0 1916146-03-6 1916145-77-1 1912880-14-8 1912880-04-6 1912879-71-0 1912879-45-8 1912471-15-8 1912471-02-3 1912470-96-2 1911438-41-9 1880074-78-1 1517048-06-4 1511055-57-4 1405420-32-7 1225016-31-8 1183508-99-7 1098397-28-4 1090851-96-9 191410-88-5 161228-90-6 161228-88-2 2298913-34-3 2133857-04-0 1991771-80-2 1988789-00-9 1987081-15-1 1963493-19-7 1963485-43-9 1963484-44-7 1963333-30-3 1963332-79-7 1963293-80-2 1963293-26-6 1963266-27-4 1963249-00-4 1963248-88-5 1963075-71-9 1962813-56-4 1961466-57-8 1958753-45-1 1958751-48-8 1942812-46-5 1942812-24-9 1942811-37-1 1939959-83-7 1939278-59-7 1939278-58-6 1939278-57-5 1939278-54-2 1933879-30-1 1933878-73-9 1931659-70-9 1931659-02-7 1931658-98-8 1931658-46-6 1931658-28-4 1930978-48-5 1930978-28-1 1930978-20-3 1927604-57-6 1927604-54-3 1927369-37-6 1917672-69-5 1916146-31-0 1916146-24-1 1916146-09-2 1916146-00-3 1916145-61-3 1912880-08-0 1912879-93-6 1912471-09-0 1987080-66-9 1986954-61-3 1912316-19-8 1882013-85-5 1877684-70-2 1874825-14-5 1874578-66-1 1874578-65-0 1866600-42-1 1857334-84-9 1490216-99-3 1483136-13-5 1457256-24-4 1308237-58-2 1218464-07-3 1225016-34-1 1225016-32-9 1961466-89-6 1927604-67-8 1549932-84-4 2163201-91-8 2024446-45-3 2006958-66-1 2004285-43-0 1996485-85-8 1995732-69-8 1991569-72-2 1991569-50-6 1990070-85-3 1987539-29-6 1987081-08-2 1987080-93-2 1986453-83-1 1983851-90-6 1983344-50-8 1983343-92-5 1983343-79-8 1983343-71-0 1983343-64-1 1983091-96-8 1983088-96-5 1982203-99-5 1981931-26-3 1981931-02-5 1963491-90-8 1963486-37-4 1963333-53-0 1963326-34-2 1963325-71-4 1963296-03-8 1963295-51-3 1963295-45-5 1963295-18-2 1963076-44-9 1962813-77-9 1962806-33-2 1961468-21-2 1961467-79-7 1960925-03-4 1960734-20-6 1960647-70-4 1959928-52-9 1944224-32-1 1944175-80-7 1944092-53-8 1939855-08-9 1933879-62-9 1933879-42-5 1933816-57-9 1933237-05-8 1933235-18-7 1933211-12-1 1933075-14-9 1931742-39-0 1931070-72-2 1930978-98-5 1930465-59-0 1930465-52-3 1927605-15-9 1927604-96-3 1927604-36-1 1916146-38-7 1912880-00-2 1912471-11-4 1777242-75-7 1712498-63-9 1516773-69-5 1513042-93-7 1503494-31-2 1481992-26-0 1477586-27-8 1378481-77-6 1307455-79-3 1306409-32-4 1304608-61-4 1183972-25-9 1183858-15-2 1183827-88-4 1178934-83-2 1999589-02-4 1994116-56-1 1988885-72-8 1988885-56-8 1987763-00-7 1987539-17-2 1986954-08-8 1986953-73-4 1986953-63-2 1986411-77-1 1984166-87-1 1983611-73-9 1983343-98-1 1983343-52-7 1983088-82-9 1982231-41-3 1982204-16-9 1982203-88-2 1981930-80-6 1964928-85-5 1963487-15-1 1963486-30-7 1963326-14-8 1963077-09-9 1962813-68-8 1962813-36-0 1962807-42-6 1962806-93-4 1961467-39-9 1961466-14-7 1961466-02-3 1959976-49-8 1958754-06-7 1958720-30-3 1942813-31-1 1942812-35-2 1942812-14-7 1939274-40-4 1939274-12-0 1933879-57-2 1933879-27-6 1933879-20-9 1933878-95-5 1933878-78-4 1933878-68-2 1931659-36-7 1931658-89-7 1931658-88-6 1931658-23-9 1931658-19-3 1931070-73-3 1930978-97-4 1930978-90-7 1930978-56-5 1930978-05-4 1930464-94-0 1930464-77-9 1927605-12-6 1927604-73-6 1927604-53-2 1927604-52-1 1927604-51-0 1927604-24-7 1923078-50-5 1485156-86-2 1469787-71-0 1409147-57-4 1378919-35-7 380344-61-6
其他中間物為式(3)之化合物：
Figure 02_image067
其中G 為鹵素，n = 1且m = 1，R1 為氫、羥基、C1 -C6 烷基或C1 -C6 烷氧基，R2 、R3 、R4 及R5 如本文所描述，R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環、芳族C6 -C14 碳環(苯基)、芳族5員至14員雜環及非芳族6員至14員多環雜環，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代，R8 為氫或C1 -C6 烷基， 其限制條件為式(3)之化合物不為
3,6-二氯-N-[2-(吡啶-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(吡啶-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(3,5-二氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(3-甲基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(3-氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-氟基-2-甲基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(3-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-羥基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(3-氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(吡啶-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(2-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-甲氧基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(2,4-二氯苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(2-氟基苯基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-羥基-2-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-甲基-1H-吡唑-1-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-羥基-2-(3-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1,3-噻唑-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-甲基-1,3-噻唑-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1,2,4-噁二唑-5-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(3-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(3-甲基-1,2,4-噁二唑-5-基)乙基]嗒𠯤-4-甲醯胺 N-[2-(5-溴-2-噻吩基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(2-呋喃基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1,2,4-噁二唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(5-氯-2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(2-甲基-1,3-噻唑-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1H-1,2,3-三唑-1-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1,3-噻唑-2-基)乙基]嗒𠯤-4-甲醯胺 1-(2-{[(3,6-二氯嗒𠯤-4-基)羰基]胺基}乙基)-1H-咪唑e-4-羧酸 3,6-二氯-N-[2-(1H-吡咯-1-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1-甲基-1H-吡唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1-甲基-1H-吡唑-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(5-甲基-1,2,4-噁二唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1H-吡唑-1-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1H-咪唑-1-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1-甲基-1H-1,2,4-三唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1H-咪唑-2-基)乙基]嗒𠯤-4-甲醯胺 2-(2-{[(3,6-二氯嗒𠯤-4-基)羰基]胺基}乙基)-1,3-噻唑-4-羧酸 3,6-二氯-N-[2-(1H-咪唑-5-基)乙基]嗒𠯤-4-甲醯胺 1-(2-{[(3,6-二氯嗒𠯤-4-基)羰基]胺基}乙基)-1H-1,2,3-三唑-4-羧酸 3,6-二氯-N-[2-(4H-1,2,4-三唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1,3-噻唑-2-基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(4-甲基-4H-1,2,4-三唑-3-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1H-咪唑-1-基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[2-(2-噻吩基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-乙基-N-(2-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-甲基-2-苯基丙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-苯基丙-2-基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(5-甲基-2-噻吩基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-噻吩基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-苯基丙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-呋喃基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[1-(2-噻吩基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1-甲基-1H-吡唑-5-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2RS)-1-羥基-3-苯基丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(1H-吡唑-1-基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(4-氟基苯基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(2-苯基乙基)嗒𠯤-4-甲醯胺 3,6-二氯-N-[(2RS)-1-羥基-3-苯基丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(3-氯苯基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-氯苯基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(2-甲基苯基)乙基]嗒𠯤-4-甲醯胺 N-[1-(4-溴苯基)丙-2-基]-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-甲基苯基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(1-羥基-3-苯基丙-2-基)嗒𠯤-4-甲醯胺 N-{[3-氯-6-(4-氯苯基)嗒𠯤-4-基]羰基}苯基丙胺酸 3,6-二氯-N-甲基-N-[2-(吡啶-2-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-甲基-2-(2-噻吩基)丙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[1-(2-噻吩基)丙-2-基]嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-[2-(吡啶-4-基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-[2-(1-甲基-1H-咪唑-2-基)乙基]嗒𠯤-4-甲醯胺 N-[(3,6-二氯嗒𠯤-4-基)羰基]組胺酸 1982206-64-3 1981930-87-3 1963486-79-4 1963267-34-6 1961466-79-4 1958752-63-0 1939713-84-4 1930978-66-7 1930464-33-7 1927604-17-8 1926106-33-3 1917672-49-1 1916146-17-2 1916145-74-8 1912316-22-3 1911438-43-1 1155518-85-6 199478-02-9 1988885-38-6 1987840-59-4 1987333-52-7 1987081-19-5 1987081-05-9 1983447-74-0 1983088-84-1 1982958-83-7 1982305-31-6 1982203-97-3 1964916-99-1 1964235-20-8 1964117-88-1 1962807-54-0 1961467-67-3 1961444-14-3 1960924-96-2 1960200-68-3 1958752-66-3 1933260-88-8 1930978-75-8 1930978-73-6 1927605-14-8 1777228-56-4 1515904-17-2 1496013-42-3 1489434-01-6 1464902-43-9 1988735-54-1 1983344-17-7 1983343-54-9 1982231-69-5 1963485-83-7 1963333-18-7 1963325-02-1 1963295-24-0 1963266-60-5 1963249-31-1 1963076-52-9 1962806-83-2 1961468-97-2 1961457-84-0 1958753-58-6 1958752-29-8 1958751-61-5 1942775-34-9 1939278-50-8 1931658-69-3 1931068-89-1 1930978-36-1 1930464-45-1 1409556-04-2 1349429-86-2 1942811-41-7 1939857-30-3 1931658-73-9 1930978-46-3 1930465-02-3 1922906-07-7
其他中間物為式(3)之化合物：
Figure 02_image069
其中G 為鹵素，n = 1且m = 1，R1 為氫、羥基、C1 -C6 烷基或C1 -C6 烷氧基R3 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基，R2 及R5 如本文所描述，R6 如本文所描述，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代，R8 為氫或C1 -C6 烷基， 其限制條件為式(3)之化合物不為
 rel-3,6-二氯-N-[(1R,2S)-2-苯基環丙基]嗒𠯤-4-甲醯胺 3-氯-N-[rac-(1S,2R)-2-(4-氯苯基)環丁基]嗒𠯤-4-甲醯胺 3-氯-N-[rac-(1R,2R)-2-(2,4-二氯苯基)環丁基]嗒𠯤-4-甲醯胺 3-氯-N-[rac-(1R,2R)-2-(2-氟苯基)環丁基]嗒𠯤-4-甲醯胺 3-氯-N-[rac-(1R,2R)-2-(2,4-二氟苯基)環丁基]嗒𠯤-4-甲醯胺 1931070-77-7 1644254-75-0 1644254-74-9 1644253-02-0 1644253-01-9
其他中間物為式(3)之化合物：
Figure 02_image071
其中G 為鹵素，n = 0且m = 0，R1 為氫、羥基、C1 -C6 烷基或C1 -C6 烷氧基，R6 係選自由以下組成之群：本文所描述之非芳族C7 -C12 碳環基氧基、芳族C6 -C14 碳環基氧基、芳族5員至14員雜環基氧基、非芳族7員至14員雜環基氧基、經非芳族C7 -C12 碳環取代之C1 -C3 烷氧基、芳族C6 -C14 碳環、非芳族7員至14員雜環或芳族5員至14員雜環、及經非芳族C7 -C12 碳環取代之C1 -C3 鹵烷氧基、芳族C6 -C14 碳環、非芳族7員至14員雜環或芳族5員至14員雜環，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如本文所揭示且其中R7 及Re 可如本文所揭示經取代，R8 為氫或C1 -C6 烷基， 其限制條件為式(3)之化合物不為
3,6-二氯-N-[2-(3-甲基苯氧基)乙基]嗒𠯤-4-甲醯胺 3,6-二氯-N-(2-苯氧基乙基)嗒𠯤-4-甲醯胺  N-[1-(苯甲氧基)-2-甲基丙-2-基]-3,6-二氯嗒𠯤-4-甲醯胺  N-[2-(苯甲氧基)乙基]-3,6-二氯嗒𠯤-4-甲醯胺  N-[1-(苯甲氧基)丙-2-基]-3,6-二氯嗒𠯤-4-甲醯胺  N-(苯甲氧基)-3,6-二氯嗒𠯤-4-甲醯胺 3,6-二氯-N-甲基-N-(2-苯氧基乙基)嗒𠯤-4-甲醯胺 1919457-49-0 1911438-37-3 1852826-24-4 1852733-87-9 1852693-57-2 1479914-20-9 1931658-25-1
根據本發明之中間物為式(4)之化合物： Q-OH (4) 其中Q 為：
Figure 02_image073
其中A 為C-H或N，QS 係選自由以下組成之群：C3 -C4 環烷基、C3 -C4 鹵環烷基、C2 -C6 烯基、C2 -C6 鹵烯基及C2 -C6 炔基， 其限制條件為式(4)之化合物不表示：
2-氟-3-(3,3,3-三氟丙-1-烯-2-基)酚 2168012-00-6
3-(1-乙氧基乙烯基)-2-氟苯酚 2137960-04-2
1-(2-氟-3-羥苯基)環丙烷甲腈 1881320-49-5
3-(1-胺基環丙基)-2-氟苯酚 1785193-75-0
1-(2-氟-3-羥苯基)環丙烷甲酸 1507131-96-5
2-氟-3-(丙-1-烯-2-基)酚 1375066-38-8
組合物及調配物 本發明進一步關於一種組合物，尤其一種用於防治非所需植物病原性微生物之組合物。可將組合物施加至微生物及/或其生境中。
該組合物通常包含至少一種式(I)之化合物及至少一種農業上適合之助劑，例如載劑及/或界面活性劑。
載劑為固體或液體、天然或合成的、有機或無機物質，其一般為惰性的。載劑一般改良化合物至例如植物、植物部分或種子之施加。適合之固體載劑 之實例包括但不限於：銨鹽；天然石粉，諸如高嶺土、黏土、滑石、白堊、石英、綠坡縷石(attapulgite)、蒙脫石及矽藻土；及合成石粉，諸如細粉狀二氧化矽、氧化鋁及矽酸鹽。通常適用於製備顆粒之固體載劑之實例包括但不限於：碾碎且分級之天然岩石，諸如方解石、大理石、浮石、海泡石及白雲石；合成的無機及有機粉末顆粒；及有機材料(諸如紙張、鋸屑、椰子殼、玉米穗軸及菸草梗)之顆粒。適合液體載劑 之實例包括但不限於水、有機溶劑及其組合。適合之溶劑之實例包括極性及非極性有機化學液體，例如來自芳族及非芳族烴類(諸如環己烷、烷烴、烷基苯、二甲苯、甲苯烷基萘、諸如氯苯、氯乙烯或二氯甲烷之氯化芳族物或氯化脂族烴)、醇及多元醇(其亦可視情況經取代、醚化及/或酯化，諸如丁醇或乙二醇)、酮(諸如丙酮、甲基乙基酮、甲基異丁酮或環己酮)、酯(包括脂肪及油)及(聚)醚、未經取代及經取代之胺、醯胺(諸如二甲基甲醯胺)、內醯胺(諸如N-烷基咯啶酮)及內酯、碸及亞碸(諸如二甲亞碸)。載劑亦可為液化氣態填充劑(亦即在標準溫度下及在標準壓力下為氣態的液體)，例如，氣溶膠推進劑，諸如，鹵烴、丁烷、丙烷、氮氣及二氧化碳。以組合物之重量計，載劑之量的範圍通常為1至99.99%、較佳地5至99.9%、更佳地10至99.5 %及最佳地20至99%。
界面活性劑可為離子(陽離子或陰離子)或非離子界面活性劑，諸如離子或非離子乳化劑、泡沫形成劑、分散劑、濕潤劑及其任何混合物。適合之界面活性劑之實例包括但不限於：聚丙烯酸之鹽、木質磺酸之鹽、酚磺酸或萘磺酸之鹽、環氧乙烷及/或環氧丙烷與脂肪醇、脂肪酸或脂肪胺之聚縮合物(聚氧乙烯脂肪酸酯、聚氧乙烯脂肪醇醚，例如烷芳基聚乙二醇醚)、經取代酚(較佳烷基酚或芳基酚)、磺化丁二酸酯之鹽、牛磺酸衍生物(較佳牛磺酸烷酯)、聚乙氧基化醇或酚之磷酸酯、多元醇之脂肪酯及含有硫酸酯、磺酸酯及磷酸酯之化合物之衍生物(例如烷基磺酸酯、硫酸烷酯、芳基磺酸酯)及蛋白質水解產物、木質亞硫酸鹽廢液及甲基纖維素。界面活性劑通常在式(I)之化合物及/或載劑不溶於水且用水進行施加時使用。那麼，界面活性劑之量通常在組合物之5至40重量%範圍內。
適合之助劑之其他實例包括：拒水劑；乾燥劑；黏合劑(黏著劑、增黏劑、固定劑，諸如羧甲基纖維素；呈粉末、顆粒或膠乳形式之天然及合成聚合物，諸如阿拉伯膠、聚乙烯醇及聚乙酸乙烯酯；諸如腦磷脂及卵磷脂之天然磷脂及合成磷脂；聚乙烯吡咯啶酮；及泰勒纖維素(tylose))；增稠劑；穩定劑(例如，低溫穩定劑、防腐劑、抗氧化劑、光穩定劑或改良化學及/或物理穩定性之其他試劑)；染料或顏料(諸如無機顏料，例如氧化鐵、氧化鈦及普魯士藍；有機染料，例如茜素、偶氮基及金屬酞菁染料)；消泡劑(例如，聚矽氧消泡劑及硬脂酸鎂)；防腐劑(例如，二氯酚及苯甲醇半縮甲醛)；二級增稠劑(纖維素衍生物、丙烯酸衍生物、三仙膠、經改質黏土及細微粉碎二氧化矽)；黏著劑；赤黴素及加工助劑；礦物及植物油；香料；蠟；營養素(包括微量營養素，諸如鐵、錳、硼、銅、鈷、鉬及鋅之鹽)；保護性膠體；搖變性物質；滲透劑；螯合劑及錯合物形成劑。
助劑之選擇與式(I)之化合物之預期應用模式及/或其物理特性有關。此外，助劑可經選擇以向組合物或自其製備之使用形式賦予特定特性(工業、物理及/或生物特性)。助劑之選擇可允許針對特定需求定製組合物。
組合物可呈任何習用形式，諸如溶液(例如水溶液)、乳液、可濕潤粉末、水基及油基懸浮液、粉末、粉塵、糊狀物、可溶性粉末、可溶性顆粒、用於散佈之顆粒、懸乳劑濃縮物、浸漬有式(I)化合物之天然或合成產物、肥料以及聚合物質之微膠囊。式(I)之化合物可以懸浮、乳化或溶解形式存在。
可將組合物作為備用調配物提供至終端使用者，亦即組合物可藉由適合裝置(諸如噴灑或撒粉裝置)直接施加至植物或種子。或者，可將呈濃縮物形式之組合物提供至終端使用者，其在使用之前必須經稀釋，較佳地用水稀釋。
組合物可以習知方式製備，例如藉由使式(I)之化合物與諸如本文上文所揭示之一或多種適合之助劑混合來製備。
組合物一般含有0.01至99重量%、0.05至98重量%、較佳地0.1至95重量%、更佳地0.5至90重量%、最佳地1至80重量%之式(I)之化合物。組合物可能包含兩種或更多種式(I)之化合物。在此情況下，概述之範圍係指本發明之化合物之總量。
混合物 / 組合 式(I)之化合物及包含其之組合物可與如殺真菌劑、殺細菌劑、殺蟎劑、殺線蟲劑、殺昆蟲劑、除草劑、肥料、生長調節劑、安全劑或訊息化合物之其他活性成分混合。此可使得活性範圍變寬或防止出現耐藥性。已知殺真菌劑、殺蟲劑、殺蟎劑、殺線蟲劑及殺菌劑之實例揭示於Pesticide Manual，第17版中。
可與式(I)化合物及組合物混合之尤其較佳殺真菌劑的實例為：
1)麥角固醇生物合成之抑制劑，例如(1.001)環克座(cyproconazole)、(1.002)待克利(difenoconazole)、(1.003)依普座(epoxiconazole)、(1.004)環醯菌胺(fenhexamid)、(1.005)苯鏽啶(fenpropidin)、(1.006)芬普福(fenpropimorph)、(1.007)胺苯吡菌酮(fenpyrazamine)、(1.008)氟喹唑(fluquinconazole)、(1.009)護汰芬(flutriafol)、(1.010)依滅列(imazalil)、(1.011)依滅列硫酸鹽(imazalil sulfate)、(1.012)種菌唑(ipconazole)、(1.013)滅特座(metconazole)、(1.014)邁克尼(myclobutanil)、(1.015)巴克素(paclobutrazol)、(1.016)撲克拉(prochloraz)、(1.017)普克利(propiconazole)、(1.018)丙硫菌唑(prothioconazole)、(1.019)啶菌噁唑(Pyrisoxazole)、(1.020)螺環菌胺(spiroxamine)、(1.021)得克利(tebuconazole)、(1.022)四克利(tetraconazole)、(1.023)三泰隆(triadimenol)、(1.024)三得芬(tridemorph)、(1.025)滅菌唑(triticonazole)、(1.026) (1R,2S,5S)-5-(4-氯苯甲基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-1-基甲基)環戊醇、(1.027) (1S,2R,5R)-5-(4-氯苯甲基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-1-基甲基)環戊醇、(1.028) (2R)-2-(1-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.029) (2R)-2-(1-氯環丙基)-4-[(1S)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.030) (2R)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丙-2-醇、(1.031) (2S)-2-(1-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.032) (2S)-2-(1-氯環丙基)-4-[(1S)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.033) (2S)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丙-2-醇、(1.034) (R)-[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-噁唑-4-基](吡啶-3-基)甲醇、(1.035) (S)-[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-噁唑-4-基](吡啶-3-基)甲醇、(1.036) [3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-噁唑--4-基](吡啶-3-基)甲醇、(1.037) 1-({(2R,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-1,3-二氧戊環-2-基}甲基)-1H-1,2,4-三唑、(1.038) 1-({(2S,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-1,3-二氧戊環-2-基}甲基)-1H-1,2,4-三唑、(1.039) 1-{[3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑-5-基硫氰酸酯、(1.040) 1-{[rel(2R,3R)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑-5-基硫氰酸酯、(1.041) 1-{[rel(2R,3S)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑-5-基硫氰酸酯、(1.042) 2-[(2R,4R,5R)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.043) 2-[(2R,4R,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.044) 2-[(2R,4S,5R)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.045) 2-[(2R,4S,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.046) 2-[(2S,4R,5R)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.047) 2-[(2S,4R,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.048) 2-[(2S,4S,5R)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.049) 2-[(2S,4S,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.050) 2-[1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.051) 2-[2-氯-4-(2,4-二氯苯氧基)苯基]-1-(1H-1,2,4-三唑-1-基)丙-2-醇、(1.052) 2-[2-氯-4-(4-氯苯氧基)苯基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.053) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.054) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)戊-2-醇、(1.055) 美芬利福康唑(Mefentrifluconazole)、(1.056) 2-{[3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.057) 2-{[rel(2R,3R)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.058) 2-{[rel(2R,3S)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.059) 5-(4-氯苯甲基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-1-基甲基)環、(1.060) 5-(烯丙基硫基)-1-{[3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑、(1.061) 5-(烯丙基硫基)-1-{[rel(2R,3R)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑、(1.062) 5-(烯丙基硫基)-1-{[rel(2R,3S)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑、(1.063) N'-(2,5-二甲基-4-{[3-(1,1,2,2-四氟乙氧基)苯基]硫基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.064) N'-(2,5-二甲基-4-{[3-(2,2,2-三氟乙氧基)苯基]硫基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.065) N'-(2,5-二甲基-4-{[3-(2,2,3,3-四氟丙氧基)苯基]硫基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.066) N'-(2,5-二甲基-4-{[3-(戊氟乙氧基)苯基]硫基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.067) N'-(2,5-二甲基-4-{3-[(1,1,2,2-四氟乙基)硫基]苯氧基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.068) N'-(2,5-二甲基-4-{3-[(2,2,2-三氟乙基)硫基]苯氧基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.069) N'-(2,5-二甲基-4-{3-[(2,2,3,3-四氟丙基)硫基]苯氧基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.070) N'-(2,5-二甲基-4-{3-[(戊氟乙基)硫基]苯氧基}苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.071) N'-(2,5-二甲基-4-苯氧基苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.072) N'-(4-{[3-(二氟乙氧基)苯基]硫基}-2,5-二甲基苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.073) N'-(4-{3-[(di氟甲基)硫基]苯氧基}-2,5-二甲基苯基)-N-乙基-N-甲基亞胺甲醯胺、(1.074) N'-[5-溴基-6-(2,3-二氫-1H-茚-2-基氧基)-2-甲基吡啶-3-基]-N-乙基-N-甲基亞胺甲醯胺、(1.075) N'-{4-[(4,5-二氯-1,3-噻唑-2-基)氧基]-2,5-二甲基苯基}-N-乙基-N-甲基亞胺甲醯胺、(1.076) N'-{5-溴基-6-[(1R)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞胺甲醯胺、(1.077) N'-{5-溴基-6-[(1S)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞胺甲醯胺、(1.078) N'-{5-溴基-6-[(cis-4-異丙基環己基)氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞胺甲醯胺、(1.079) N'-{5-溴基-6-[(反式-4-異丙基環己基)氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞胺甲醯胺、(1.080) N'-{5-溴基-6-[1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞胺甲醯胺、(1.081) 異丙氟脲唑(Ipfentrifluconazole)。
2)錯合物I或II處之呼吸鏈之抑制劑，例如(2.001)苯丙烯氟菌唑(benzovindiflupyr)、(2.002)必殺吩(bixafen)、(2.003)白可列(boscalid)、(2.004)萎鏽靈(carboxin)、(2.005)氟吡菌醯胺(fluopyram)、(2.006)福多寧(flutolanil)、(2.007)氟唑菌醯胺(fluxapyroxad)、(2.008)福拉比(furametpyr)、(2.009)艾索非他米(Isofetamid)、(2.010)吡唑萘菌胺(isopyrazam)(抗差向異構對映異構體1R,4S,9S)、(2.011)吡唑萘菌胺(抗差向異構對映異構體1S,4R,9R)、(2.012)吡唑萘菌胺(抗差向異構外消旋體1RS,4SR,9SR)、(2.013)吡唑萘菌胺(同側差向異構外消旋體1RS,4SR,9RS及抗差向異構外消旋體1RS,4SR,9SR之混合物)、(2.014)吡唑萘菌胺(同側差向異構對映異構體1R,4S,9R)、(2.015)吡唑萘菌胺(同側差向異構對映異構體1S,4R,9S)、(2.016)吡唑萘菌胺(同側差向異構外消旋體1RS,4SR,9RS)、(2.017)噴福芬(penflufen)、(2.018)吡噻菌胺(penthiopyrad)、(2.019)吡二氟甲多芬(pydiflumetofen)、(2.020)吡瑞氟密得(Pyraziflumid)、(2.021)氟唑環菌胺(sedaxane)、(2.022) 1,3-二甲基-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)-1H-吡唑-4-甲醯胺、(2.023) 1,3-二甲基-N-[(3R)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.024) 1,3-二甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.025) 1-甲基-3-(三氟甲基)-N-[2'-(三氟甲基)聯苯基-2-基]-1H-吡唑-4-甲醯胺、(2.026) 2-氟-6-(三氟甲基)-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)苯甲醯胺、(2.027) 3-(二氟甲基)-1-甲基-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)-1H-吡唑-4-甲醯胺、(2.028) 3-(二氟甲基)-1-甲基-N-[(3R)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.029) 3-(二氟甲基)-1-甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.030)氟林達吡(Fluindapyr)、(2.031) 3-(二氟甲基)-N-[(3R)-7-氟-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1-甲基-1H-吡唑-4-甲醯胺、(2.032) 3-(二氟甲基)-N-[(3S)-7-氟-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1-甲基-1H-吡唑-4-甲醯胺、(2.033) 5,8-二氟-N-[2-(2-氟-4-{[4-(三氟甲基)吡啶-2-基]氧基}苯基)乙基]喹唑啉-4-胺、(2.034) N-(2-環戊基-5-氟苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.035) N-(2-第三-丁基-5-甲基苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.036) N-(2-第三-丁基苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.037) N-(5-氯-2-乙基苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.038)異黃酮(isoflucypram)、(2.039) N-[(1R,4S)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.040) N-[(1S,4R)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.041) N-[1-(2,4-二氯苯基)-1-甲氧基丙-2-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.042) N-[2-氯-6-(三氟甲基)苯甲基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.043) N-[3-氯-2-氟-6-(三氟甲基)苯甲基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.044) N-[5-氯-2-(三氟甲基)苯甲基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.045) N-環丙基-3-(二氟甲基)-5-氟-1-甲基-N-[5-甲基-2-(三氟甲基)苯甲基]-1H-吡唑-4-甲醯胺、(2.046) N-環丙基-3-(二氟甲基)-5-氟-N-(2-氟-6-異丙基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.047) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基-5-甲基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.048) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苯甲基)-1-甲基-1H-吡唑-4-硫代醯胺、(2.049) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.050) N-環丙基-3-(二氟甲基)-5-氟-N-(5-氟-2-異丙基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.051) N-環丙基-3-(二氟甲基)-N-(2-乙基-4,5-二甲基苯甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.052) N-環丙基-3-(二氟甲基)-N-(2-乙基-5-氟苯甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.053) N-環丙基-3-(二氟甲基)-N-(2-乙基-5-甲基苯甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.054) N-環丙基-N-(2-環丙基-5-氟苯甲基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.055) N-環丙基-N-(2-環丙基-5-甲基苯甲基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.056) N-環丙基-N-(2-環丙基苯甲基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.057)吡喃丙炔(pyrapropoyne)。
3)錯合物III處之呼吸鏈之抑制劑，例如(3.001)辛唑嘧菌胺(ametoctradin)、(3.002)吲唑磺菌胺(amisulbrom)、(3.003)亞托敏(azoxystrobin)、(3.004)甲香菌酯(coumethoxystrobin)、(3.005)丁香菌酯(coumoxystrobin)、(3.006)賽座滅(cyazofamid)、(3.007)地莫菌胺(dimoxystrobin)、(3.008)亞烷基嘧菌酯(enoxastrobin)、(3.009)凡殺同(famoxadone)、(3.010)咪唑菌酮(fenamidone)、(3.011)氟菌蟎酯(flufenoxystrobin)、(3.012)氟嘧菌酯(fluoxastrobin)、(3.013)克收欣(kresoxim-methyl)、(3.014)苯氧菌胺(metominostrobin)、(3.015)肟醚菌胺(orysastrobin)、(3.016)啶氧菌酯(picoxystrobin)、(3.017)百克敏(pyraclostrobin)、(3.018)唑胺菌酯(pyrametostrobin)、(3.019)唑菌酯(pyraoxystrobin)、(3.020)三氟敏(trifloxystrobin)、(3.021) (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-氟-2-苯基乙烯基]氧基}苯基)亞乙基]胺基}氧基)甲基]苯基}-2-(甲氧亞胺基)-N-甲基乙醯胺、(3.022) (2E,3Z)-5-{[1-(4-氯苯基)-1H-吡唑-3-基]氧基}-2-(甲氧亞胺基)-N,3-二甲基戊-3-烯醯胺、(3.023) (2R)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺、(3.024) (2S)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺、(3.025) (3S,6S,7R,8R)-8-苯甲基-3-[({3-[(異丁氧基)甲氧基]-4-甲氧基吡啶-2-基}羰基)胺基]-6-甲基-4,9-二氧-1,5-二氧萘-7-基2-甲基丙酸酯、(3.026)曼地斯特羅賓(mandestrobin)、(3.027) N-(3-乙基-3,5,5-三甲基環己基)-3-甲醯胺-2-氫氧基苯甲醯胺、(3.028) (2E,3Z)-5-{[1-(4-氯-2-氟苯基)-1H-吡唑-3-基]氧基}-2-(甲氧亞胺基)-N,3-二甲基戊-3-烯醯胺、(3.029)甲基{5-[3-(2,4-二甲基苯基)-1H-吡唑-1-基]-2-甲基苯甲基}胺基甲酸酯、(3.030)苯基吡唑類(metyltetraprole)、(3.031)氟吡唑嗪(florylpicoxamid)。
4)有絲分裂及細胞分裂之抑制劑，例如(4.001)多菌靈(carbendazim)、(4.002)乙黴威(diethofencarb)、(4.003)噻唑菌胺(ethaboxam)、(4.004)氟吡菌胺(fluopicolide)、(4.005)賓克隆(pencycuron)、(4.006)噻苯達唑(thiabendazole)、(4.007)甲基托布津(thiophanate-methyl)、(4.008)座賽胺(zoxamide)、(4.009) 3-氯-4-(2,6-二氟苯基)-6-甲基-5-苯基嗒𠯤、(4.010) 3-氯-5-(4-氯苯基)-4-(2,6-二氟苯基)-6-甲基嗒𠯤、(4.011) 3-氯-5-(6-氯吡啶-3-yl)-6-甲基-4-(2,4,6-三氟苯基)嗒𠯤、(4.012) 4-(2-溴基-4-氟苯基)-N-(2,6-二氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.013) 4-(2-溴基-4-氟苯基)-N-(2-溴基-6-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.014) 4-(2-溴基-4-氟苯基)-N-(2-溴基苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.015) 4-(2-溴基-4-氟苯基)-N-(2-氯-6-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.016) 4-(2-溴基-4-氟苯基)-N-(2-氯苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.017) 4-(2-溴基-4-氟苯基)-N-(2-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.018) 4-(2-氯-4-氟苯基)-N-(2,6-二氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.019) 4-(2-氯-4-氟苯基)-N-(2-氯-6-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.020) 4-(2-氯-4-氟苯基)-N-(2-氯苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.021) 4-(2-氯-4-氟苯基)-N-(2-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.022) 4-(4-氯苯基)-5-(2,6-二氟苯基)-3,6-二甲基嗒𠯤、(4.023) N-(2-溴基-6-氟苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.024) N-(2-溴基苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.025) N-(4-氯-2,6-二氟苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-1H-吡唑-5-胺。
5)能夠具有多位點作用之化合物，例如(5.001)紫紅混合物、(5.002)四氯丹、(5.003)蓋普丹(captan)、(5.004)四氯異苯腈、(5.005)氫氧化銅、(5.006)環烷酸銅、(5.007)銅氧化物、(5.008)鹼性氯氧化銅、(5.009)硫酸銅(2+)、(5.010)腈硫醌、(5.011)多寧(dodine)、(5.012)福爾培(folpet)、(5.013)鋅錳乃浦(mancozeb)、(5.014)錳乃浦(maneb)、(5.015)免得爛(metiram)、(5.016)免得爛鋅、(5.017)咢辛-銅、(5.018)甲基鋅乃浦、(5.019)包括鈣聚硫化物之硫及硫製劑、(5.020)得恩地(thiram)、(5.021)鋅乃浦(zineb)、(5.022)益穗(ziram)、(5.023)6-乙基-5,7-二側氧基-6,7-二氫-5H-吡咯并[3',4':5,6][1,4]二噻𠯤并[2,3-c][1,2]噻唑-3-甲腈。
6)能夠引發宿主防護之化合物，例如：(6.001)活化酯-S-甲基、(6.002)異噻菌胺(isotianil)、(6.003)撲殺熱(probenazole)、(6.004)汰敵寧(tiadinil)。
7)胺基酸及/或蛋白質生物合成之抑制劑，例如(7.001)嘧菌環胺(cyprodinil)、(7.002)春日黴素(kasugamycin)、(7.003)水合春日黴素鹽酸鹽、(7.004)土黴素(oxytetracycline)、(7.005)嘧黴胺(pyrimethanil)、(7.006) 3-(5-氟-3,3,4,4-四甲基-3,4-二氫異喹啉-1-基)喹啉。
8) ATP產生之抑制劑，例如(8.001)矽硫芬。
9)細胞壁合成之抑制劑，例如：(9.001)苯噻菌胺、(9.002)達滅芬、(9.003)氟嗎啉、(9.004)纈黴威、(9.005)雙炔醯菌胺、(9.006)丁吡嗎啉、(9.007)威利芬那雷特、(9.008)(2E)-3-(4-第三丁基苯基)-3-(2-氯吡啶-4-基)-1-(嗎啉-4-基)丙-2-烯-1-酮、(9.009)(2Z)-3-(4-第三丁基苯基)-3-(2-氯吡啶-4-基)-1-(嗎啉-4-基)丙-2-烯-1-酮。
10)脂質及膜合成之抑制劑，例如：(10.001)霜黴威(propamocarb)、(10.002)霜黴威鹽酸鹽、(10.003)甲基脫克松(tolclofos-methyl)。
11)黑色素生物合成之抑制劑，例如：(11.001)三賽唑(tricyclazole)、(11.002) {3-甲基-1-[(4-甲基苯甲醯基)胺基]丁-2-基}胺基甲酸2,2,2-三氟乙酯。
12)核酸合成之抑制劑，例如：(12.001)本達樂(benalaxyl)、(12.002)本達樂-M (精苯霜靈(kiralaxyl))、(12.003)滅達樂(metalaxyl)、(12.004)滅達樂-M (右滅達樂(mefenoxam))。
13)信號轉導之抑制劑，例如：(13.001)護汰寧(fludioxonil)、(13.002)依普同(iprodione)、(13.003)撲滅寧(procymidone)、(13.004)丙氧喹啉(proquinazid)、(13.005)快諾芬(quinoxyfen)、(13.006)免克寧(vinclozolin)。
14)能夠充當解偶聯劑之化合物，例如：(14.001)扶吉胺(fluazinam)、(14.002)敵蟎普(meptyldinocap)。
15)其他化合物，例如(15.001)脫落酸(Abscisic acid)、(15.002)苯噻硫氰(benthiazole)、(15.003)吡托沙嗪(bethoxazin)、(15.004)卡巴西黴素(capsimycin)、(15.005)香芹酮(carvone)、(15.006)蟎離丹(chinomethionat)、(15.007)硫雜靈(cufraneb)、(15.008)環氟菌胺(cyflufenamid)、(15.009)克絕(cymoxanil)、(15.010)環丙磺醯胺(cyprosulfamide)、(15.011)氟替尼(flutianil)、(15.012)福賽得鋁(fosetyl-aluminium)、(15.013)福賽得鈣(fosetyl-calcium)、(15.014)福賽得鈉(fosetyl-sodium)、(15.015)異硫氰酸甲酯、(15.016)滅芬農(metrafenone)、(15.017)米多黴素(mildiomycin)、(15.018)遊黴素(natamycin)、(15.019)二甲基二硫代胺基甲酸鎳(nickel dimethyldithiocarbamate)、(15.020)滅鏽胺-異丙基(nitrothal-isopropyl)、(15.021)奧克斯莫卡賓(oxamocarb)、(15.022)奧賽普林(oxathiapiprolin)、(15.023)奧克斯芬塞林(oxyfenthiin)、(15.024)五氯苯酚及鹽、(15.025)亞磷酸及其鹽、(15.026)霜黴威-乙膦酸鹽(propamocarb-fosetylate)、(15.027)甲氧苯唳菌(pyriofenone) (氯芬酮(chlazafenone))、(15.028)特普弗洛奎(tebufloquin)、(15.029)克枯爛(tecloftalam)、(15.030)甲磺菌胺(tolnifanide)、(15.031) 1-(4-{4-[(5R)-5-(2,6-二氟苯基)-4,5-二氫-1,2-噁唑-3-基]-1,3-噻唑-2-基}哌啶-1-基)-2-[5-甲基-3-(三氟甲基)-1H-吡唑-1-基]乙酮、(15.032) 1-(4-{4-[(5S)-5-(2,6-二氟苯基)-4,5-二氫-1,2-噁唑-3-基]-1,3-噻唑-2-基}哌啶-1-基)-2-[5-甲基-3-(三氟甲基)-1H-吡唑-1-基]乙酮、(15.033) 2-(6-苯甲基吡啶-2-基)喹唑啉、(15.034) 二異丙胺酮(dipymetitrone)、(15.035) 2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-(丙-2-炔-1-基氧基)苯基]-4,5-二氫-1,2-噁唑-3-基}-1,3-噻唑-2-基)哌啶-1-基]乙酮、(15.036) 2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-氯-6-(丙-2-炔-1-基氧基)苯基]-4,5-二氫-1,2-噁唑-3-基}-1,3-噻唑-2-基)哌啶-1-基]乙酮、(15.037) 2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-氟-6-(丙-2-炔-1-基氧基)苯基]-4,5-二氫-1,2-噁唑-3-基}-1,3-噻唑-2-基)哌啶-1-基]乙酮、(15.038) 2-[6-(3-氟-4-甲氧基苯基)-5-甲基吡啶-2-基]喹唑啉、(15.039) 2-{(5R)-3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-噁唑-5-基}-3-氯苯基甲磺酸酯、(15.040) 2-{(5S)-3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-噁唑-5-基}-3-氯苯基 甲磺酸酯、(15.041)依氟芬喹(Ipflufenoquin)、(15.042) 2-{2-氟-6-[(8-氟-2-甲基喹啉-3-基)氧基]苯基}丙-2-醇、(15.043) 2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-噁唑-5-基}-3-氯苯基甲磺酸酯、(15.044) 2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-噁唑-5-基}苯基甲磺酸酯、(15.045) 2-苯基苯酚及鹽、(15.046) 3-(4,4,5-三氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉、(15.047)喹諾福美林(quinofumelin)、(15.048) 4-胺基-5-氟嘧啶-2-醇(互變異構形式：4-胺基-5-氟嘧啶-2(1H)-酮)、(15.049) 4-氧基-4-[(2-苯基乙基)胺基]丁酸、(15.050) 5-胺基-1,3,4-噻二唑-2-硫醇、(15.051) 5-氯-N'-苯基-N'-(丙-2-炔-1-基)噻吩-2-磺醯肼、(15.052) 5-氟-2-[(4-氟苯甲基)氧基]嘧啶-4-胺、(15.053) 5-氟-2-[(4-甲基苯甲基)氧基]嘧啶-4-胺、(15.054) 9-氟-2,2-二甲基-5-(喹啉-3-基)-2,3-二氫-1,4-苯并氮呯、(15.055)丁-3-炔-1-基{6-[({[(Z)-(1-甲基-1H-四唑-5-基)(苯基)亞甲基]胺基}氧基)甲基]吡啶-2-基}胺基甲酸酯、(15.056)乙基(2Z)-3-胺基-2-氰基-3-苯基丙烯酸酯、(15.057)吩嗪-1-羧酸、(15.058)丙基3,4,5-三羥基苯甲酸酯、(15.059)喹啉-8-醇、(15.060)喹啉-8-醇硫酸酯(2:1)、(15.061)第三-丁基{6-[({[(1-甲基-1H-四唑-5-基)(苯基)亞甲基]胺基}氧基)甲基]吡啶-2-基}胺基甲酸酯、(15.062) 5-氟-4-亞胺基-3-甲基-1-[(4-甲基苯基)磺醯基]-3,4-二氫嘧啶-2(1H)-酮、(15.063)胺基吡喃芬。
如本文上文中所描述之類別(1)至(15)之所有提及的混合搭配物，可以游離化合物形式及/或(若其官能基致能此)其農業上可接受之鹽形式存在。
式(I)之化合物及組合物亦可與一或多種生物控制劑組合。
可與式(I)之化合物及包含其之組合物組合的生物控制劑之實例為：
( A ) 選自以下之群的抗細菌劑 ：
(A1)細菌，諸如(A1.1)枯草桿菌(Bacillus subtilis )，詳言之，菌株QST713/AQ713 (可以SERENADE OPTI或SERENADE ASO形式自美國Bayer CropScience LP獲得，具有NRRL寄存編號B21661且描述於美國專利第6,060,051號中)；(A1.2)解澱粉芽孢桿菌(Bacillus amyloliquefaciens )，詳言之，菌株D747 (可以Double Nickel™形式自美國Certis獲得，具有寄存編號FERM BP-8234且揭示於美國專利第7,094,592號中)；(A1.3)短小芽孢桿菌(Bacillus pumilus )，詳言之，菌株BU F-33 (具有NRRL寄存編號50185)；(A1.4)枯草桿菌變種解澱粉芽孢桿菌(Bacillus subtilis var . amyloliquefaciens )菌株FZB24 (可以Taegro®形式自美國Novozymes獲得)；(A1.5)類芽孢桿菌屬(Paenibacillus sp . )菌株，其具有寄存編號NRRL B-50972或寄存編號NRRL B-67129且描述於國際專利公開案第WO 2016/154297號中；及
(A2)真菌，諸如(A2.1)出芽短梗黴菌(Aureobasidium pullulans )，詳言之，菌株DSM14940之芽生孢子；(A2.2)菌株DSM 14941之出芽短梗黴菌(Aureobasidium pullulans )芽生孢子；(A2.3)出芽短梗黴菌(Aureobasidium pullulans )，詳言之，菌株DSM14940及DSM14941之芽生孢子的混合物；
(B)選自以下之群的殺真菌劑：
(B1)細菌，例如(B1.1)枯草桿菌，詳言之菌株QST713/AQ713 (可以SERENADE OPTI或SERENADE ASO之形式自美國Bayer CropScience LP獲得，其具有NRRL寄存編號B21661且描述於美國專利第6,060,051號中)；(B1.2)短小芽孢桿菌，詳言之菌株QST2808 (可以SONATA®形式自美國Bayer CropScience LP獲得，其具有寄存編號NRRL B-30087且描述於美國專利第6,245,551號中)；(B1.3)短小芽孢桿菌，詳言之菌株GB34 (可以Yield Shield®之形式自德國Bayer AG獲得)；(B1.4)短小芽孢桿菌，詳言之菌株BU F-33 (具有NRRL寄存編號50185)；(B1.5)解澱粉芽孢桿菌，詳言之菌株D747 (可以Double Nickel™之形式自美國Certis獲得，其具有寄存編號FERM BP-8234且揭示於美國專利第7,094,592號中)；(B1.6)枯草桿菌Y1336 (可以BIOBAC® WP形式自臺灣Bion-Tech獲得，其在臺灣以註冊號4764、5454、5096及5277註冊為生物殺真菌劑)；(B1.7)解澱粉芽孢桿菌菌株MBI 600 (可以SUBTILEX形式自BASF SE獲得)；(B1.8)枯草桿菌菌株GB03 (可以Kodiak®形式自德國Bayer AG獲得)；(B1.9)枯草桿菌變種解澱粉芽孢桿菌菌株FZB24 (可自Novozymes Biologicals Inc., Salem, Virginia或Syngenta Crop Protection, LLC, Greensboro, North Carolina以殺真菌劑TAEGRO® 或TAEGRO® ECO (EPA註冊號70127 -5)形式獲得)；(B1.10)蕈狀桿菌分離株J (可以BmJ TGAI或WG自美國Certis獲得)；(B1.11)地衣芽孢桿菌，詳言之菌株SB3086 (可以EcoGuard TM生物殺真菌劑及Green Releaf自Novozymes獲得)；(B1.12)類芽孢桿菌屬菌株，其具有寄存編號NRRL B-50972或寄存編號NRRL B-67129且描述於國際專利公開案第WO 2016/154297號中。
在一些實施例中，生物控制劑為產生豐原素(fengycin)或大側柏素(plipastatin)類化合物、伊枯草菌素(iturin)類化合物及/或表面活性素類化合物的枯草桿菌或解澱粉芽孢桿菌菌株。對於先前技術，參見以下評論文章：Ongena, M.等人, 「Bacillus Lipopeptides:  Versatile Weapons for Plant Disease Biocontrol」, Trends in Microbiology, 第16卷, 第3期, 2008年3月, 第115-125頁。能夠產生脂肽之芽孢桿菌(Bacillus )菌株包括枯草桿菌QST713 (可以SERENADE OPTI或SERENADE ASO形式自美國Bayer CropScience LP獲得，其具有NRRL寄存編號B21661且描述於美國專利第6,060,051號中)；解澱粉芽孢桿菌菌株D747 (可以Double Nickel™形式自美國Certis獲得，其具有寄存編號FERM BP-8234且揭示於美國專利第7,094,592號中)；枯草桿菌MBI600 (可以SUBTILEX® 形式自Becker Underwood獲得，USEPA 寄存編號 71840 - 8 )；枯草桿菌Y1336 (可以BIOBAC® WP形式自臺灣Bion-Tech獲得，其在臺灣以寄存編號4764、5454、5096及5277註冊為生物殺真菌劑)；解澱粉芽孢桿菌，詳言之菌株FZB42 (可以RHIZOVITAL® 形式自德國ABiTEP獲得)；以及枯草桿菌變種解澱粉芽孢桿菌FZB24 (可以殺真菌劑TAEGRO® 或TAEGRO® ECO (EPA寄存編號70127-5)形式自Novozymes Biologicals Inc., Salem, Virginia或Syngenta Crop Protection, LLC, Greensboro, North Carolina獲得)；以及
(B2)真菌，例如：(B2.1)盾殼黴(Coniothyrium minitans )，尤其菌株CON/M/91-8(寄存編號DSM-9660；例如來自Bayer之Contans®；(B2.2)核果梅奇酵母(Metschnikowia fructicola )，尤其菌株NRRL Y-30752(例如Shemer®)；(B2.3)赫色小球殼孢菌(Microsphaeropsis ochracea )(例如來自Prophyta之Microx®)；(B2.5)木黴屬(Trichoderma spp . )，包括國際申請案第PCT/IT2008/000196號中所描述之菌株SC1)；(B2.6)哈茨木黴菌株(Trichoderma harzianum rifai )KRL-AG2(亦稱為菌株T-22/ATCC 208479，例如PLANTSHIELD T-22G、Rootshield®及來自BioWorks, US之TurfShield)；(B2.14)來自W.F. Stoneman Company LLC之粉紅膠黴菌(Gliocladium roseum )，菌株321U；(B2.35)黃色籃狀菌(Talaromyces flavus )，菌株V117b； (B2.36)來自Isagro之棘孢木黴(Trichoderma asperellum )，菌株ICC 012；(B2.37)棘孢木黴(Trichoderma asperellum )，菌株SKT-1(例如來自Kumiai Chemical Industry之ECO-HOPE®)；(B2.38)深綠木黴菌(Trichoderma atroviride )，菌株CNCM I-1237 (例如來自Agrauxine, FR之Esquive® WP)；(B2.39)深綠木黴菌，菌株第V08/002387號；(B2.40)深綠木黴菌，菌株NMI第V08/002388號； (B2.41)深綠木黴菌，菌株NMI編號V08/002389；(B2.42)深綠木黴菌，菌株NMI編號V08/002390；(B2.43)深綠木黴菌，菌株LC52 (例如，Agrimm Technologies Limited之Tenet)；(B2.44)深綠木黴菌，菌株ATCC 20476 (IMI 206040)；(B2.45)深綠木黴菌，菌株T11 (IMI352941/CECT20498)；(B2.46)鉤狀木黴菌(Trichoderma harmatum )；(B2.47)哈氏木黴菌；(B2.48)里法伊哈氏木黴菌T39 (例如，來自美國Makhteshim之Trichodex®)；(B2.49)哈氏木黴菌，詳言之，菌株KD (例如，來自Biological Control Products之Trichoplus，SA (由Becker Underwood獲得))；(B2.50)哈氏木黴菌，菌株ITEM 908 (例如，來自Koppert之Trianum-P)； (B2.51)哈氏木黴菌，菌株TH35(例如Mycontrol之Root-Pro)；(B2.52)木黴菌屬(Trichodermavirens )(亦稱為綠黏帚黴(Gliocladium virens ))，特定言之菌株GL-21(例如Certis, US之SoilGard 12G)；(B2.53)木黴菌屬，菌株TV1(例如Koppert之Trianum-P)；(B2.54)白粉寄生孢(Ampelomyces quisqualis )，特定言之菌株AQ 10(例如IntrachemBio Italia之AQ 10®)；(B2.56)出芽短梗黴菌(Aureobasidium pullulans )，特定言之菌株DSM14940之芽生孢子；(B2.57)出芽短梗黴菌，特定言之菌株DSM 14941之芽生孢子；(B2.58)出芽短梗黴菌，特定言之菌株DSM14940及DSM 14941之芽生孢子的混合物(例如bio-ferm, CH之Botector®)； (B2.64)芽枝黴菌(Cladosporium cladosporioides )，菌株H39 (Stichting Dienst Landbouwkundig Onderzoek)；(B2.69)鏈抱黏帚菌(Gliocladium catenulatum ) (同義詞：鏈狀粉紅黏帚黴(Clonostachys rosea f . catenulate )菌株J1446 (例如，AgBio Inc.之Prestop®以及例如Kemira Agro Oy之Primastop®)；(B2.70)菌株KV01 (例如，Koppert/Arysta之Vertalec®)之臘蚧輪刺孢菌(Lecanicillium lecanii ) (以前稱為蠟蚧輪枝菌(Verticillium lecanii )分生孢子；(B2.71)蠕形青黴(Penicillium vermiculatum )；(B2.72)異常畢赤酵母(Pichia anomala )，菌株WRL-076 (NRRL Y-30842)；(B2.75)深綠木黴菌，菌株SKT-1 (FERM P-16510)；(B2.76)深綠木黴菌，菌株SKT-2 (FERM P-16511)；(B2.77)深綠木黴菌，菌株SKT-3 (FERM P-17021)；(B2.78)蓋姆斯木黴(Trichoderma gamsii ) (以前綠色木黴)，菌株ICC080 (IMI CC 392151 CABI，例如AGROBIOSOL DE MEXICO, S.A. DE C.V.之BioDerma)；(B2.79)哈茨木黴，strain DB 103 (例如Dagutat Biolab之T-Gro 7456)；(B2.80)多孢木黴(Trichoderma polysporum)，菌株IMI 206039 (例如，瑞典BINAB Bio-Innovation AB之Binab TF WP)；(B2.81)子座木黴(Trichoderma stromaticum ) (例如，巴西Ceplac之Tricovab)；(B2.83)奧德曼細基格孢(Ulocladium oudemansii )，尤其菌株HRU3 (例如，Botry-Zen Ltd, NZ之Botry-Zen®)；(B2.84)黑白輪枝菌(Verticillium albo - atrum ) (以前大麗輪枝菌)，菌株WCS850 (CBS 276.92；例如Tree Care Innovations之Dutch Trig)；(B2.86)厚孢輪枝菌(Verticillium chlamydosporium )；(B2.87)棘孢木黴菌株ICC 012及蓋姆斯木黴菌株ICC 080之混合物(將產品稱為例如來自美國Bayer CropScience LP之BIO-TAMTM )。
可與式(I)之化合物及包含其之組合物組合之生物控制劑之其他實例為： 選自由以下組成之群的細菌：蠟樣芽胞桿菌(Bacillus cereus )，詳言之蠟狀芽孢桿菌(B . cereus )菌株CNCM I-1562及強固芽胞桿菌(Bacillus firmus )菌株I-1582 (寄存編號CNCM I-1582)；枯草桿菌菌株OST 30002 (寄存編號NRRL B-50421)；蘇力菌(Bacillus thuringiensis )，詳言之蘇雲金芽孢桿菌以色列亞種(B . thuringiensis subspeciesisraelensis )(血清型H-14)，菌株AM65-52 (寄存編號ATCC 1276)，蘇雲金芽孢桿菌亞莎華亞種(B . thuringiensis subsp . aizawai )，詳言之菌株ABTS-1857 (SD-1372)，蘇雲金芽孢桿菌庫斯塔克亞種(B . thuringiensis subsp . kurstaki )菌株HD-1，蘇雲金芽孢桿菌擬步行甲亞種(B . thuringiensis subsp . tenebrionis )菌株NB 176 (SD-5428)；穿刺巴斯德芽菌(Pasteuria penetrans )，巴斯德氏菌屬(腎狀線蟲)-PR3 (寄存編號ATCC SD-5834)；細黃鏈黴菌(Streptomyces microflavus )菌株AQ6121 (=QRD 31.013，NRRL B-50550)；及鮮黃鏈黴菌菌株AQ 6047 (寄存編號NRRL 30232)； 選自由以下組成之群的真菌及酵母：白殭菌(Beauveria bassiana )，詳言之菌株ATCC 74040；輪枝菌屬(Lecanicillium spp .)，詳言之菌株HRO LEC 12；黑殭菌(Metarhizium anisopliae )，詳言之菌株F52 (DSM3884或ATCC 90448)；玫煙色擬青黴(Paecilomyces fumosoroseus ； 現為Isaria fumosorosea )，詳言之菌株IFPC 200613或菌株Apopka 97 (寄存編號ATCC 20874)；及淡紫擬青黴(Paecilomyces lilacinus )，詳言之淡紫擬青黴菌株251 (AGAL 89/030550)； 選自由以下組成之群的病毒：茶姬卷葉蛾(Adoxophyes orana )(夏季水果卷葉蛾)顆粒體病毒(granulosis virus；GV)；蘋果蠹蛾(Cydia pomonella )(蘋果卷葉蛾)顆粒體病毒(GV)；番茄夜蛾(Helicoverpa armigera )(棉鈴蟲)核多角體病毒(NPV)；甜菜菜蛾(Spodoptera exigua )(甜菜夜蛾) mNPV；草地黏蟲(Spodoptera frugiperda )(秋夜蛾) mNPV；及灰翅夜蛾(Spodoptera littoralis )(非洲棉葉蟲) NPV。
可以『接種劑』形式添加至植物或植物部分或植物器官且由於其特定特性而有助於植物生長及植物健康的細菌及真菌。實例為：農桿菌屬(Agrobacterium spp . )、莖瘤固氮根瘤菌(Azorhizobium caulinodans )、固氮螺旋菌屬(Azospirillum spp . )、固氮菌屬(Azotobacter spp . )、慢生根瘤菌屬(Bradyrhizobium spp . )、伯克霍爾德菌屬(Burkholderia spp . )(尤其洋蔥伯克霍爾德氏菌(以前稱為洋蔥假單胞菌))、巨孢囊黴屬(Gigaspora spp . )或單孢球囊黴(Gigaspora monosporum )、叢枝菌根菌屬(Glomus spp . )、蠟蘑菌屬(Laccaria spp . )、布氏乳桿菌(Lactobacillus buchneri )、類球囊黴屬(Paraglomus spp . )、彩色豆馬勃(Pisolithus tinctorus )、假單胞菌屬(Pseudomonas spp . )、根瘤菌屬(Rhizobium spp . )(尤其三葉草根瘤菌)、麥蕈屬(Rhizopogon spp . )、硬皮馬勃屬(Scleroderma spp . )、兔蕈屬(Suillus spp . )及鏈黴菌屬(Streptomyces spp . )。
可用作生物控制劑的包括蛋白質及次級代謝物的植物萃取物及由微生物形成的產物，諸如蒜(Allium sativum )、中亞苦蒿(Artemisia absinthium )、印楝素(azadirachtin )、Biokeeper WP、黑決明(Cassia nigricans )、苦皮藤(Celastrus angulatus )、藜屬土荊芥(Chenopodium anthelminticum )、甲殼素、Armour-Zen、歐洲鱗毛蕨(Dryopteris filix - mas )、問荊(Equisetum arvense )、Fortune Aza、薄荷油(Fungastop )、Heads Up (藜麥(Chenopodium quinoa )皂素萃取物)、除蟲菊/除蟲菊精(Pyrethrum / Pyrethrins )、蘇林南苦木(Quassia amara )、櫟屬(Quercus )、皂皮樹屬(Quillaja )、Regalia、「Requiem ™殺昆蟲劑」、魚藤酮、魚尼丁/理阿諾鹼(ryania /ryanodine)、聚合草(Symphytum officinale )、菊蒿(Tanacetum vulgare )、瑞香草酚、Triact 70、TriCon、旱金蓮(Tropaeulum majus )、異株蕁麻(Urtica dioica )、藜蘆鹼(Veratrin)、槲寄生(Viscum album )、十字花科(Brassicaceae )萃取物，尤其油菜粉或芥末粉。
分別可與式(I)之化合物及包含其之組合物混合的殺昆蟲劑、殺蟎劑及殺線蟲劑之實例為： (1)乙醯膽鹼酯酶(AChE)抑制劑，諸如(例如)胺基甲酸酯，例如棉靈威(alanycarb)、得滅克(aldicarb)、惡蟲威(bendiocarb)、免扶克(benfuracarb)、丁酮威(butocarboxim)、丁酮碸威(butoxycarboxim)、加保利(carbaryl)、加保扶(carbofuran)、丁基加保扶(carbosulfan)、殺蟲丹(ethiofencarb)、仲丁威(fenobucarb)、複滅蟎(formetanate)、呋線威(furathiocarb)、葉蟬散(isoprocarb)、滅賜克(methiocarb)、納乃得(methomyl)、速滅威(metolcarb)、歐殺滅(oxamyl)、比加普(pirimicarb)、安丹(propoxur)、硫敵克(thiodicarb)、久效威(thiofanox)、唑蚜威(triazamate)、混滅威(trimethacarb)、XMC及滅殺威(xylylcarb)；或有機磷酸酯，例如歐殺松(acephate)、亞滅松(azamethiphos)、乙基穀速松(azinphos-ethyl)、甲基穀速松(azinphos-methyl)、硫線磷(cadusafos)、氯氧磷(chlorethoxyfos)、克芬松(chlorfenvinphos)、氯甲磷(chlormephos)、甲基陶斯松(chlorpyrifos-methyl)、蠅毒磷(coumaphos)、殺螟腈(cyanophos)、甲基硫代內吸磷(demeton-S-methyl)、大利松(diazinon)、二氯松(dichlorvos)/DDVP、雙特松(dicrotophos)、大滅松(dimethoate)、甲基毒蟲畏(dimethylvinphos)、二硫松(disulfoton)、EPN、愛殺松(ethion)、普伏松(ethoprophos)、伐滅磷(famphur)、芬滅松(fenamiphos)、撲滅松(fenitrothion)、芬殺松(fenthion)、噻唑磷(fosthiazate)、庚烯磷(heptenophos)、新菸磷(imicyafos)、異柳磷(isofenphos)、O-(甲氧基胺基硫基磷醯基)水楊酸異丙酯、加福松(isoxathion)、馬拉松(malathion)、滅蚜磷(mecarbam)、達馬松(methamidophos)、滅大松(methidathion)、美文松(mevinphos)、亞素靈(monocrotophos)、二溴磷(naled)、氧樂果(omethoate)、甲基滅多松(oxydemeton-methyl)、甲基巴拉松(parathion-methyl)、賽達松(phenthoate)、福瑞松(phorate)、裕必松(phosalone)、益滅松(phosmet)、福賜米松(phosphamidon)、巴賽松(phoxim)、甲基亞特松(pirimiphos-methyl)、布飛松(profenofos)、巴胺磷(propetamphos)、普硫松(prothiofos)、吡唑硫磷(pyraclofos)、嗒𠯤硫磷(pyridaphenthion)、喹惡磷(quinalphos)、治螟磷(sulfotep)、丁基嘧啶磷(tebupirimfos)、雙硫磷(temephos)、託福松(terbufos)、樂本松(tetrachlorvinphos)、甲基乙拌磷(thiometon)、三落松(triazophos)、三氯松(triclorfon)及蚜滅多(vamidothion)。 (2) GABA閘控氯離子通道阻斷劑，諸如環戊二烯-有機氯類，例如氯丹(chlordane)及安殺番(endosulfan)或苯基吡唑(非潑羅(fiproles))，例如乙蟲清(ethiprole)及費普尼(fipronil)。 (3)鈉通道調節劑，諸如(例如)擬除蟲菊酯，例如氟丙菊酯(acrinathrin)、丙烯菊酯(allethrin)、d-順式反式丙烯菊酯、d-反式丙烯菊酯、畢芬寧(bifenthrin)、生物丙烯菊酯、s-環戊烯基生物丙烯菊酯異構體、苄呋菊脂(bioresmethrin)、乙氰菊脂(cycloprothrin)、賽扶寧(cyfluthrin)、β-賽扶甯、賽洛寧(cyhalothrin)、λ-賽洛寧、γ-賽洛甯、賽滅寧(cypermethrin)、α-賽滅寧、β-賽滅寧、θ-賽滅寧、ξ-賽滅甯、賽酚寧[(1R)-反式異構體]、第滅寧(deltamethrin)、烯炔菊酯[(EZ)-(1R)-異構體]、益化利(esfenvalerate)、依芬寧(etofenprox)、芬普寧(fenpropathrin)、芬化利(fenvalerate)、護賽寧(flucythrinate)、氟氯苯菊酯(flumethrin)、τ-氟胺氰菊酯(tau-fluvalinate)、苄蟎醚(halfenprox)、依普寧(imiprothrin)、噻嗯菊酯(kadethrin)、沫氟寧(momfluorothrin)、百滅寧(permethrin)、苯醚菊酯[(1R)-反式異構體]、普亞列寧(prallethrin)、除蟲菊精(除蟲菊)、苄呋菊脂(resmethrin)、矽護芬(silafluofen)、七氟菊酯(tefluthrin)、治滅寧(tetramethrin)、治滅寧[(1R)-異構體]、泰滅寧(tralomethrin)及拜富寧(transfluthrin)或DDT或甲氧滴滴涕(methoxychlor)。 (4)菸鹼乙醯膽鹼受體(nAChR)競爭性調節劑，諸如(例如)新菸鹼類似物類，例如啶蟲脒(acetamiprid)、可尼丁(clothianidin)、呋蟲胺(dinotefuran)、吡蟲啉(imidacloprid)、烯啶蟲胺(nitenpyram)、噻蟲啉(thiacloprid)及噻蟲嗪(thiamethoxam)或菸鹼或氟啶蟲胺腈(sulfoxaflor)或氟吡呋喃酮(flupyradifurone)。 (5)菸鹼乙醯膽鹼受體(nAChR)異位調節劑，諸如(例如)賜諾殺類(spinosyn)，例如斯平托蘭(spinetoram)及賜諾殺(spinosad)。 (6)麩胺酸閘控氯離子通道(GluCl)異位調節劑，諸如阿維菌素類(avermectin)/米爾倍黴素類(milbemycin)，例如阿巴汀(abamectin)、因滅汀苯甲酸酯(emamectin benzoate)、林皮沒丁(lepimectin)及密滅汀(milbemectin)。 (7)青少年激素模擬物，諸如青少年激素類似物，例如烯蟲乙酯(hydroprene)、烯蟲炔酯(kinoprene)及美賜平(methoprene)或芬諾克(fenoxycarb)或百利普芬(pyriproxyfen)。 (8)各種非特異性(多位點)抑制劑，諸如(例如)烷基鹵化物，例如溴化甲烷及其他烷基鹵化物；或氯化苦或磺醯氟或硼砂或牙垢催吐劑或異氰酸甲酯產生劑，例如必速滅(diazomet)及威百畝(metam)。 (9)弦音器官(Chordotonal Organs)之調節劑，諸如(例如)派滅淨(pymetrozine)或氟啶蟲醯胺(flonicamid)。 (10)蟎生長抑制劑，諸如克芬蟎(clofentezine)、合賽多(hexythiazox)及氟蟎嗪(diflovidazin)或依殺蟎(etoxazole)。 (11)昆蟲腸膜之微生物瓦解劑，諸如蘇力菌以色列亞種、枯草芽孢桿菌、蘇力菌亞莎華亞種、蘇力菌庫斯塔克亞種、蘇力菌擬步行甲亞種亞種及B.t.植物蛋白：Cry1Ab、Cry1Ac、Cry1Fa、Cry1A.105、Cry2Ab、Vip3A、mCry3A、Cry3Ab、Cry3Bb、Cry34Ab1/35Ab1。 (12)粒線體ATP合成酶之抑制劑，諸如ATP瓦解劑，諸如(例如)汰芬諾克(diafenthiuron)或有機錫化合物，例如三唑錫(azocyclotin)、錫蟎丹(cyhexatin)及芬布錫(fenbutatin oxide)或毆蟎多(propargite)或四氯殺蟎碸(tetradifon)。 (13)經由破壞質子梯度氧化磷酸化之去偶合劑，諸如克凡派(chlorfenapyr)、DNOC及氟蟲胺(sulfluramid)。 (14)菸鹼乙醯膽鹼受體通道阻斷劑，諸如殺蟲磺(bensultap)、培丹鹽酸鹽(cartap hydrochloride)、硫賜安(thiocylam)及殺蟲雙鈉(thiosultap-sodium)。 (15)甲殼素生物合成之抑制劑，0型，諸如雙三氟蟲脲(bistrifluron)、克福隆(chlorfluazuron)、二福隆(diflubenzuron)、氟環脲(flucycloxuron)、氟芬隆(flufenoxuron)、六伏隆(hexaflumuron)、祿芬隆(lufenuron)、諾伐隆(novaluron)、多氟脲(noviflumuron)、得福隆(teflubenzuron)及三福隆(triflumuron)。 (16)甲殼素生物合成之抑制劑，1型，例如布芬淨(buprofezin)。 (17)脫皮干擾劑(特定言之用於雙翅目，亦即雙翅目昆蟲)，諸如(例如)賽滅淨(cyromazine)。 (18)蛻皮激素受體促效劑，諸如(例如)環蟲醯肼(chromafenozide)、合芬隆(halofenozide)、滅芬諾(methoxyfenozide)及得芬諾(tebufenozide)。 (19)章魚胺受體促效劑，諸如(例如)三亞蟎(amitraz)。 (20)粒線體錯合物III電子傳輸抑制劑，諸如(例如)伏蟻腙(hydramethylnone)或亞醌蟎(acequinocyl)或嘧蟎酯(fluacrypyrim)。 (21)粒線體錯合物I電子傳輸抑制劑，諸如來自METI殺蟎劑之群，例如芬殺蟎(fenazaquin)、芬普蟎(fenpyroximate)、嘧蟎醚(pyrimidifen)、比達本(pyridaben)、得芬瑞(tebufenpyrad)及脫芬瑞(tolfenpyrad)或魚藤酮(rotenone)(魚藤(Derris))。 (22)電壓依賴性鈉通道阻斷劑，諸如因得克(indoxacarb)或氰氟蟲胺(metaflumizone)。 (23)乙醯CoA羧化酶之抑制劑，諸如特窗酸(tetronic acid)及特特拉姆酸(tetramic acid)衍生物，例如賜派芬(spirodiclofen)、螺甲蟎酯(spiromesifen)及螺蟲乙酯(spirotetramat)。 (24)粒線體錯合物IV電子傳輸抑制劑，諸如膦，例如磷化鋁、磷化鈣、膦及磷化鋅；或氰化物，例如氰化鈣、氰化鉀及氰化鈉。 (25)粒線體錯合物II電子傳輸抑制劑，諸如β-開托利(beta-ketonitrile)衍生物，例如腈吡蟎酯(cyenopyrafen)及丁氟蟎酯(cyflumetofen)，及甲苯胺類，諸如吡氟蟎酯(pyflubumide)。 (28)理阿諾鹼受體調節劑，諸如二醯胺類，例如氯蟲苯甲醯胺(chlorantraniliprole)、氰強尼普羅(cyantraniliprole)及氟蟲雙醯胺(flubendiamide)， 其他活性化合物，諸如雙丙環蟲酯(Afidopyropen)、阿福拉納(Afoxolaner)、印楝素(Azadirachtin)、苯氯噻(Benclothiaz)、苯蟎特(Benzoximate)、畢芬載(Bifenazate)、溴蟲氟苯雙醯胺(Broflanilide)、溴蟎酯(Bromopropylate)、蟎離丹(Chinomethionat)、右旋反式氯丙炔菊酯(Chloroprallethrin)、冰晶石(Cryolite)、右旋反式氯丙炔菊酯(Cyclaniliprole)、環氧蟲啶(Cycloxaprid)、氯氟氰蟲醯胺(Cyhalodiamide)、二氯加士(Dicloromezotiaz)、開樂散(Dicofol)、ε-甲氧苄氟菊酯(epsilon-Metofluthrin)、ε-單氟菊酯(ε-Momfluthrin)、孚蟎喹(Flometoquin)、三氟咪啶醯胺(Fluazaindolizine)、氟噻蟲碸(Fluensulfone)、氟芬內林(Flufenerim)、氟菌蟎酯(Flufenoxystrobin)、丁蟲腈(Flufiprole)、福薩豐(Fluhexafon)、氟吡菌醯胺(Fluopyram)、弗拉拉納(Fluralaner)、氣釀醯胺(Fluxametamide)、呋喃蟲醯肼(Fufenozide)、戊吡蟲胍(Guadipyr)、右旋七氟甲醚菊酯(Heptafluthrin)、氯噻啉(Imidaclothiz)、依普同(Iprodione)、κ-畢芬寧(kappa-Bifenthrin)、κ-七氟菊酯(kappa-Tefluthrin)、洛替拉納(Lotilaner)、氯氟醚菊酯(Meperfluthrin)、哌蟲啶(Paichongding)、啶蟲丙醚(Pyridalyl)、哌氟喹腙(Pyrifluquinazon)、嘧蟎胺(Pyriminostrobin)、螺蝴雙醋(Spirobudiclofen)、四氟醚菊酯(Tetramethylfluthrin)、氟氰蟲醯胺(Tetraniliprole)、四氯蟲醯胺(Tetrachlorantraniliprole)、泰格藍喏(Tigolaner)、硫噁唑芬(Tioxazafen)、硫氟肟醚(Thiofluoximate)、三氟苯嘧啶(Triflumezopyrim)及碘甲烷(iodomethane)；其他基於強固芽胞桿菌(Bacillus firmus )之製劑(I-1582, BioNeem, Votivo)， 以及以下化合物：1-{2-氟-4-甲基-5-[(2,2,2-三氟乙基)亞磺醯基]苯基}-3-(三氟甲基)-1H-1,2,4-三唑-5-胺(自WO2006/043635已知)(CAS 885026-50-6)、{1'-[(2E)-3-(4-氯苯基)丙-2-烯-1-基]-5-氟螺[吲哚-3,4'-哌啶]-1(2H)-基}(2-氯吡啶-4-基)甲酮(自WO2003/106457已知)(CAS 637360-23-7)、2-氯-N-[2-{1-[(2E)-3-(4-氯苯基)丙-2-烯-1-基]哌啶-4-基}-4-(三氟甲基)苯基]異菸鹼醯胺(自WO2006/003494已知)(CAS 872999-66-1)、3-(4-氯-2,6-二甲基苯基)-4-羥基-8-甲氧基-1,8-二氮螺[4.5]癸-3-烯-2-酮(自WO 2010052161已知)(CAS 1225292-17-0)、碳酸3-(4-氯-2,6-二甲基苯基)-8-甲氧基-2-側氧基-1,8-二氮螺[4.5]癸-3-烯-4-基乙酯(自EP2647626已知)(CAS1440516-42-6)、4-(丁-2-炔-1-基氧基)-6-(3,5-二甲基哌啶-1-基)-5-氟嘧啶(自WO2004/099160已知)(CAS 792914-58-0)、PF1364 (自JP2010/018586已知)(CAS 1204776-60-2)、N-[(2E)-1-[(6-氯吡啶-3-基)甲基]吡啶-2(1H )-亞基]-2,2,2-三氟乙醯胺(自WO2012/029672已知)(CAS 1363400-41-2)、(3E )-3-[1-[(6-氯-3-吡啶基)甲基]-2-伸吡啶基]-1,1,1-三氟-丙-2-酮(自WO2013/144213已知)(CAS 1461743-15-6)、N -[3-(苯甲基胺甲醯基)-4-氯苯基]-1-甲基-3-(五氟乙基)-4-(三氟甲基)-1H -吡唑-5-甲醯胺(自WO2010/051926已知)(CAS 1226889-14-0)、5-溴-4-氯-N -[4-氯-2-甲基-6-(甲基胺甲醯基)苯基]-2-(3-氯-2-吡啶基)吡唑-3-甲醯胺(自CN103232431已知)(CAS 1449220-44-3)、4-[5-(3,5-二氯苯基)-4,5-二氫-5-(三氟甲基)-3-異噁唑基]-2-甲基-N -(順-1-氧離子基-3-硫雜環丁烷基)-苯甲醯胺、4-[5-(3,5-二氯苯基)-4,5-二氫-5-(三氟甲基)-3-異噁唑基]-2-甲基-N -(反式-1-氧離子基-3-硫雜環丁烷基)-苯甲醯胺及4-[(5S )-5-(3,5-二氯苯基)-4,5-二氫-5-(三氟甲基)-3-異噁唑基]-2-甲基-N -(順-1-氧離子基-3-硫雜環丁烷基)苯甲醯胺(自WO 2013/050317A1已知)(CAS 1332628-83-7)、N -[3-氯-1-(3-吡啶基)-1H -吡唑-4-基]-N -乙基-3-[(3,3,3-三氟丙基)亞磺醯基]-丙醯胺、(+)-N -[3-氯-1-(3-吡啶基)-1H -吡唑-4-基]-N -乙基-3-[(3,3,3-三氟丙基)亞磺醯基]-丙醯胺及(-)-N -[3-氯-1-(3-吡啶基)-1H -吡唑-4-基]-N -乙基-3-[(3,3,3-三氟丙基)亞磺醯基]-丙醯胺(自WO 2013/162715 A2、WO 2013/162716 A2、US 2014/0213448 A1已知)(CAS 1477923-37-7)、5-[[(2E )-3-氯-2-丙烯-1-基]胺基]-1-[2,6-二氯-4-(三氟甲基)苯基]-4-[(三氟甲基)亞磺醯基]-1H -吡唑-3-甲腈(自CN 101337937 A已知)(CAS 1105672-77-2)、3-溴-N-[4-氯-2-甲基-6-[(甲胺基)硫代甲基]苯基]-1-(3-氯-2-吡啶基)-1H -吡唑-5-甲醯胺(硫代苯甲醯胺，自CN 103109816 A已知)(CAS 1232543-85-9)；N -[4-氯-2-[[(1,1-二甲基乙基)胺基]羰基]-6-甲基苯基]-1-(3-氯-2-吡啶基)-3-(氟甲氧基)-1H -吡唑-5-甲醯胺(自WO 2012/034403 A1已知)(CAS 1268277-22-0)、N -[2-(5-胺基-1,3,4-噻二唑-2-基)-4-氯-6-甲基苯基]-3-溴-1-(3-氯-2-吡啶基)-1H -吡唑-5-甲醯胺(自WO 2011/085575 A1已知)(CAS 1233882-22-8)、4-[3-[2,6-二氯-4-[(3,3-二氯-2-丙烯-1-基)氧基]苯氧基]丙氧基]-2-甲氧基-6-(三氟甲基)-嘧啶(自CN 101337940 A已知)(CAS 1108184-52-6)；(2E)-及2(Z)-2-[2-(4-氰基苯基)-1-[3-(三氟甲基)苯基]亞乙基]-N-[4-(二氟甲氧基)苯基]-肼甲醯胺(自CN 101715774 A已知)(CAS 1232543-85-9)； 3-(2,2-二氯乙烯基)-2,2-二甲基-4-(1H -苯并咪唑-2-基)苯基-環丙烷甲酸酯(自CN 103524422 A已知)(CAS 1542271-46-4)； (4aS )-7-氯-2,5-二氫-2-[[(甲氧羰基)[4-[(三氟甲基)硫基]苯基]胺基]羰基]-茚并[1,2-e ][1,3,4]噁二嗪-4a(3H )-甲酸甲酯(自CN 102391261 A已知)(CAS 1370358-69-2)；6-去氧-3-O - 乙基-2,4-二-O - 甲基-、1-[N -[4-[1-[4-(1,1,2,2,2-五氟乙氧基)苯基]-1H -1,2,4-三唑-3-基]苯基]胺基甲酸酯]-α-L-吡喃甘露糖(自US 2014/0275503 A1已知)(CAS 1181213-14-8)；8-(2-環丙基甲氧基-4-三氟甲基-苯氧基)-3-(6-三氟甲基-嗒𠯤-3-基)-3-氮雜-雙環[3.2.1]辛烷(CAS 1253850-56-4)、(8-反)-8-(2-環丙基甲氧基-4-三氟甲基-苯氧基)-3-(6-三氟甲基-嗒𠯤-3-基)-3-氮雜-雙環[3.2.1]辛烷(CAS 933798-27-7)、(8-同側)-8-(2-環丙基甲氧基-4-三氟甲基-苯氧基)-3-(6-三氟甲基-嗒𠯤-3-基)-3-氮雜-雙環[3.2.1]辛烷(自WO 2007040280 A1、WO 2007040282 A1已知)(CAS 934001-66-8)、N -[3-氯-1-(3-吡啶基)-1H -吡唑-4-基]-N -乙基-3-[(3,3,3-三氟丙基)硫基]-丙醯胺(自WO 2015/058021 A1、WO 2015/058028 A1已知)(CAS 1477919-27-9)及N -[4-(胺基硫代甲基)-2-甲基-6-[(甲胺基)羰基]苯基]-3-溴-1-(3-氯-2-吡啶基)-1H -吡唑-5-甲醯胺(自CN 103265527 A已知)(CAS 1452877-50-7)、5-(1,3-二噁烷-2-基)-4-[[4-(三氟甲基)苯基]甲氧基]-嘧啶(自WO 2013/115391 A1已知)(CAS 1449021-97-9)、3-(4-氯-2,6-二甲基苯基)-4-羥基-8-甲氧基-1-甲基-1,8-二氮雜螺[4.5]癸-3-烯-2-酮(自WO 2010/066780 A1、WO 2011/151146 A1已知)(CAS 1229023-34-0)、3-(4-氯-2,6-二甲基苯基)-8-甲氧基-1-甲基-1,8-二氮雜螺[4.5]癸烷-2,4-二酮(自WO 2014/187846 A1已知)(CAS 1638765-58-8)、3-(4-氯-2,6-二甲基苯基)-8-甲氧基-1-甲基-2-側氧基-1,8-二氮雜螺[4.5]癸-3-烯-4-基-碳酸乙酯(自WO 2010/066780 A1、WO 2011151146 A1已知)(CAS 1229023-00-0)、N-[1-[(6-氯-3-吡啶基)甲基]-2(1H )-伸吡啶基]-2,2,2-三氟-乙醯胺(自DE 3639877 A1、WO 2012029672 A1已知)(CAS 1363400-41-2)、[N(E )]-N-[1-[(6-氯-3-吡啶基)甲基]-2(1H )-伸吡啶基]-2,2,2-三氟-乙醯胺(自WO 2016005276 A1已知)(CAS 1689566-03-7)、[N(Z )]-N-[1-[(6-氯-3-吡啶基)甲基]-2(1H )-伸吡啶基]-2,2,2-三氟-乙醯胺(CAS 1702305-40-5)、3-內 -3-[2-丙氧基-4-(三氟甲基)苯氧基]-9-[[5-(三氟甲基)-2-吡啶基]氧基]-9-氮雜雙環[3.3.1]壬烷(自WO 2011/105506 A1、WO 2016/133011 A1已知)(CAS 1332838-17-1)。
可與式(I)之化合物及包含其之組合物混合的安全劑之實例為：例如解草酮(benoxacor)、(庚基)解毒喹(cloquintocet)、解草胺腈(cyometrinil)、環丙磺醯胺、二氯丙烯胺、(乙基)解草唑(fenchlorazole)、解草啶(fenclorim)、解草安(flurazole)、肟草安(fluxofenim)、呋喃解草唑(furilazole)、雙苯噁唑酸(isoxadifen(-ethyl))、吡唑解草酯(mefenpyr(-diethyl))、萘二甲酸酐、解草腈(oxabetrinil)、2-甲氧基-N-({4-[(甲基胺甲醯基)胺基]苯基}磺醯基)苯甲醯胺(CAS 129531-12-0)、4-(二氯乙醯基)-1-氧雜-4-氮雜螺[4.5]癸烷(CAS 71526-07-3)、2,2,5-三甲基-3-(二氯乙醯基)-1,3-噁唑啶(CAS 52836-31-4)。
可與式(I)之化合物及包含其之組合物混合的除草劑之實例為： 乙草胺(Acetochlor)、三氟羧草醚(acifluorfen)、鈉三氟羧草醚(acifluorfen-sodium)、苯草醚(aclonifen)、甲草胺(alachlor)、草毒死(allidochlor)、禾草滅(alloxydim)、鈉禾草滅(alloxydim-sodium)、莠滅淨(ametryn)、胺唑草酮(amicarbazone)、先甲草胺(amidochlor)、醯嘧磺隆(amidosulfuron)、4-胺基-3-氯-6-(4-氯-2-氟-3-甲基苯基)-5-氟吡啶-2-甲酸、環丙嘧啶酸(aminocyclopyrachlor)、環丙嘧啶酸鉀(aminocyclopyrachlor-potassium)、環丙嘧啶酸甲酯(aminocyclopyrachlor-methyl)、氯胺吡啶酸(aminopyralid)、殺草強(amitrole)、胺磺酸銨(ammoniumsulfamate)、莎稗磷(anilofos)、黃草靈(asulam)、莠去津(atrazine)、草芬定(azafenidin)、四唑嘧磺隆(azimsulfuron)、氟丁醯草胺(beflubutamid)、草除靈(benazolin)、草除靈乙酯(benazolin-ethyl)、氟草胺(benfluralin)、呋草磺(benfuresate)、苄嘧磺隆(bensulfuron)、苄嘧磺隆甲酯(bensulfuron-methyl)、地散磷(bensulide)、滅草松(bentazone)、苯并雙環酮(benzobicyclon)、吡草酮(benzofenap)、雙環比隆(bicyclopyron)、必芬諾(bifenox)畢拉草(bilanafos)、鈉畢拉草(bilanafos-sodium)、雙草醚(bispyribac)、雙草醚鈉(bispyribac-sodium)、除草定(bromacil)、溴丁醯草胺(bromobutide)、溴酚肟(bromofenoxim)、溴苯腈(bromoxynil)、丁酸溴苯腈(bromoxynil-butyrate)、溴苯腈鉀、庚酸溴苯腈及辛酸溴苯腈、比芬農(busoxinone)、丁草胺(butachlor)、氟丙嘧草酯(butafenacil)、抑草磷(butamifos)、丁烯草胺(butenachlor)、比達寧(butralin)、丁苯草酮(butroxydim)、丁草敵(butylate)、唑草胺(cafenstrole)、長殺草(carbetamide)、克繁草(carfentrazone)、乙基克繁草(carfentrazone-ethyl)、克爛本(chloramben)、氯溴隆(chlorbromuron)、伐草克(chlorfenac)、伐草克-鈉、燕麥酯、氯甲丹、氯甲丹-甲基、氯草敏(chloridazon)、氯嘧磺隆(chlorimuron)、氯嘧磺隆-乙基、氯酞(chlorophthalim)、綠麥隆(chlorotoluron)、敵草索-二甲基(chlorthal-dimethyl)、氯磺隆(chlorsulfuron)、吲哚酮草酯(cinidon)、吲哚酮草酯-乙基、環庚草醚(cinmethylin)、醚磺隆(cinosulfuron)、氯醯草膦(clacyfos)、克草同(clethodim)、炔草酸(clodinafop)、炔草酸-炔丙基、可滅蹤(clomazone)、稗草胺(clomeprop)、畢克草(clopyralid)、氯酯磺草胺(cloransulam)、氯酯磺草胺-甲基、苄草隆(cumyluron)、氰胺、氰草津(cyanazine)、環草敵(cycloate)、環磷礦(cyclopyrimorate)、環磺隆(cyclosulfamuron)、環殺草(cycloxydim)、氰氟草酯(cyhalofop)、氰氟草酯-丁基、環草津(cyprazine)、2,4-D、2,4-D-丁氧基乙基、-丁基、-二甲胺、-二醇胺、-乙基、-2-乙基己基、-異丁基、-異辛基、-異丙銨、-鉀、-三異丙銨及-三乙醇胺、2,4-DB、2,4-DB-丁酯、-二甲基銨、-異辛酯、-鉀及-鈉；殺草隆(daimuron；dymron)、茅草枯(dalapon)、棉隆(dazomet)、正癸醇、甜菜安(desmedipham)、detosyl-吡唑特(pyrazolate)(DTP)、麥草畏(dicamba)、敵草腈(dichlobenil)、2-(2,4-二氯苯甲基)-4,4-二甲基-1,2-噁唑啶-3-酮、2-(2,5-二氯苯甲基)-4,4-二甲基-1,2-噁唑啶-3-酮、滴丙酸(dichlorprop)、高滴丙酸(dichlorprop-P)、禾草靈(diclofop)、禾草靈(diclofop-methyl)、高禾草靈(diclofop-P-methyl)、雙氯磺草胺(diclosulam)、苯敵快(difenzoquat)、吡氟草胺(diflufenican)、二氟吡隆(diflufenzopyr)、二氟吡隆-鈉、噁唑隆(dimefuron)、哌草丹(dimepiperate)、二甲草胺(dimethachlor)、異戊乙淨(dimethametryn)、二甲噻草胺(dimethenamid)、高效二甲噻草胺(dimethenamid-P)、醚磺隆(dimetrasulfuron)、敵樂胺(dinitramine)、特樂酚(dinoterb)、草乃敵(diphenamid)、敵草快(diquat)、敵草快(diquat-dibromid)、氟硫草定(dithiopyr)、達有龍(diuron)、DNOC、草多索(endothal)、EPTC、戊草丹(esprocarb)、乙丁烯氟靈(ethalfluralin)、胺苯磺隆(ethametsulfuron)、胺苯磺隆(ethametsulfuron-methyl)、乙嗪草酮(ethiozin)、乙呋草黃(ethofumesate)、氯氟草醚(ethoxyfen)、氯氟草醚乙酯(ethoxyfen-ethyl)、乙氧嘧磺隆(ethoxysulfuron)、乙氧苯草胺(etobenzanid)；F-9600、F-5231、亦即N-{2-氯-4-氟-5-[4-(3-氟丙基)-5-側氧基-4,5-二氫-1H-四唑-1-基]苯基}乙磺醯胺；F-7967，亦即3-[7-氯-5-氟-2-(三氟甲基)-1H-苯并咪唑-4-基]-1-甲基-6-(三氟甲基)嘧啶-2,4(1H,3H)-二酮；精噁唑禾草靈(fenoxaprop)、精噁唑禾草靈(fenoxaprop-P)、噁唑禾草靈(fenoxaprop-ethyl)、高噁唑禾草靈(fenoxaprop-P-ethyl)、異噁苯碸(fenoxasulfone)、芬昆諾三酮(fenquinotrione)、四唑醯草胺(fentrazamide)、麥草伏(flamprop)、高效麥草伏異丙酯(flamprop-M-isopropyl)、高效麥草伏甲酯(flamprop-M-methyl)、嘧啶磺隆(flazasulfuron)、雙氟磺草胺(florasulam)、吡氟禾草靈(fluazifop)、吡氟禾草靈(fluazifop-P)、吡氟禾草靈(fluazifop-butyl)、精吡氟禾草靈(fluazifop-P-butyl)、氟酮磺隆(flucarbazone)、氟酮磺隆鈉(flucarbazone-sodium)、氟吡磺隆(flucetosulfuron)、氟消草(fluchloralin)、氟噻草胺(flufenacet)、氟嗒𠯤草酯(flufenpyr)、氟嗒𠯤草酯(flufenpyr-ethyl)、唑嘧磺草胺(flumetsulam)、氟胺草酸(flumiclorac)、氟烯草酸(flumiclorac-pentyl)、丙炔氟草胺(flumioxazin)、伏草隆(fluometuron)、抑草丁(flurenol)；芴醇-丁酯(flurenol-butyl)、-二甲基銨及-甲酯；乙羧氟草醚(fluoroglycofen)、乙羧氟草醚(fluoroglycofen-ethyl)、四氟丙酸(flupropanate)、氟啶嘧磺隆(flupyrsulfuron)、氟啶嘧磺隆鈉(flupyrsulfuron-methyl-sodium)、氟啶草酮(fluridone)、氟咯草酮(flurochloridone)、氟草定(fluroxypyr)、氯氟吡氧乙酸異辛酯(fluroxypyr-meptyl)、呋草酮(flurtamone)、氟噻草酯(fluthiacet)、氟噻甲草酯(fluthiacet-methyl)、氟磺胺草醚(fomesafen)、氟磺胺草醚鈉、甲醯嘧磺隆(foramsulfuron)、殺木膦(fosamine)、草銨膦(glufosinate)、草銨膦銨(glufosinate-ammonium)、精草銨膦鈉(glufosinate-P-sodium)、精草銨膦銨、精草銨膦鈉、草甘膦(glyphosate)、草甘膦銨、草甘膦異丙銨、草甘膦二銨、草甘膦二甲銨、草甘膦鉀、草甘膦鈉及草甘膦三甲硫；H-9201，亦即O-(2,4-二甲基-6-硝基苯基)O-乙基異丙基硫代磷醯胺酯；氟氯吡啶酯(halauxifen)、氟氯吡啶酯(halauxifen-methyl)、氟硝磺醯胺(halosafen)、氯吡嘧磺隆(halosulfuron)、氯吡嘧磺隆(halosulfuron-methyl)、吡氟氯禾靈(haloxyfop)、精吡氟氯禾靈(haloxyfop-P)、吡氟氯禾靈-乙氧基乙酯(haloxyfop-ethoxyethyl)、精吡氟氯禾靈-乙氧基乙酯(haloxyfop-P-ethoxyethyl)、吡氟氯禾靈-甲酯(haloxyfop-methyl)、精吡氟氯禾靈甲酯(haloxyfop-P-methyl)、六嗪酮(hexazinone)、 HW-02 (亦即1-(二甲氧基磷醯基)乙基-(2,4-二氯苯氧基)醋酸)、咪草酸(imazamethabenz)、咪草酸(imazamethabenz-methyl)、甲氧咪草菸(imazamox)、銨基甲氧咪草菸(imazamox-ammonium)、甲基咪草菸(imazapic)、咪唑甲菸酸銨(imazapic-ammonium)、依滅草(imazapyr)、依滅草異丙銨(imazapyr-isopropylammonium)、滅草喹(imazaquin)、滅草喹銨、咪草菸(imazethapyr)、咪草菸-亞胺鎓(imazethapyr-immonium)、唑吡嘧磺隆(imazosulfuron)、茚草酮(indanofan)、茚嗪氟草胺(indaziflam)、碘甲磺隆(iodosulfuron)、碘甲磺隆鈉(iodosulfuron-methyl-sodium)、碘苯腈(ioxynil)、碘苯腈辛酸酯(ioxynil-octanoate)、碘苯腈鉀及碘苯腈鈉、三唑醯草胺(ipfencarbazone)、異丙隆(isoproturon)、異惡隆(isouron)、異噁草胺(isoxaben)、異噁唑草酮(isoxaflutole)、卡草靈(karbutilate)、KUH-043 (亦即3-({[5-(二氟甲基)-1-甲基-3-(三氟甲基)-1H-吡唑-4-基]甲基}磺醯基)-5,5-二甲基-4,5-二氫-1,2-噁唑)、酮吡咯(ketospiradox)、乳氟禾草靈(lactofen)、環草定(lenacil)、利穀隆(linuron)、MCPA、MCPA-丁氧基乙酯、MCPA-二甲基銨、MCPA-2-乙基己酯、MCPA-異丙銨、MCPA-鉀及MCPA-鈉；MCPB、MCPB-甲酯、MCPB-乙酯及MCPB-鈉；2-甲-4-氯丙酸(mecoprop)、2-甲-4-氯丙酸鈉及2-甲-4-氯丙酸丁氧基乙酯、高2-甲-4-氯丙酸(mecoprop-P)、高2-甲-4-氯丙酸丁氧基乙酯(mecoprop-P-butotyl)、高2-甲-4-氯丙酸-2-乙基己酯及高2-甲-4-氯丙酸鉀、苯噻醯草胺(mefenacet)、氟磺醯草胺(mefluidide)、甲基二磺隆(mesosulfuron)、甲基二磺隆(mesosulfuron-methyl)、甲基磺草酮(mesotrione)、甲基苯噻隆(methabenzthiazuron)、威百畝(metam)、噁唑醯草胺(metamifop)、苯嗪草酮(metamitron)、吡草胺(metazachlor)、雙醚氯吡嘧磺隆(metazosulfuron)、甲基苯噻隆(methabenzthiazuron)、甲硫嘧磺隆(methiopyrsulfuron)、甲硫唑啉(methiozolin)、異硫氰酸甲酯(methyl isothiocyanate)、溴穀隆(metobromuron)、異丙甲草胺(metolachlor)、高效異丙甲草胺(S-metolachlor)、磺草唑胺(metosulam)、甲氧隆(metoxuron)、賽克津(metribuzin)、甲磺隆(metsulfuron)、甲磺隆(metsulfuron-methyl)、禾草敵(molinat)、綠穀隆(monolinuron)、單嘧磺隆(monosulfuron)、單嘧磺酯(monosulfuron-ester)、MT-5950 (亦即N-(3-氯-4-異丙基苯基)-2-甲基戊醯胺)、NGGC-011、敵草胺(napropamide)、NC-310 (亦即[5-(苯甲氧基)-1-甲基-1H-吡唑-4-基](2,4-二氯苯基)甲酮)、草不隆(neburon)、菸嘧磺隆(nicosulfuron)、壬酸(nonanoic acid；pelargonic acid)、達草滅(norflurazon)、油酸(脂肪酸)、坪草丹(orbencarb)、嘧苯胺磺隆(orthosulfamuron)、氨磺樂靈(oryzalin)、丙炔噁草酮(oxadiargyl)、噁草酮(oxadiazon)、環氧嘧磺隆(oxasulfuron)、去稗安(oxaziclomefon)、乙氧氟草醚(oxyfluorfen)、百草枯(paraquat)、百草枯二氯化物(paraquat dichloride)、克草猛(pebulate)、二甲戊樂靈(pendimethalin)、平速爛(penoxsulam)、五氯苯酚(pentachlorophenol)、環戊噁草酮(pentoxazone)、烯草胺(pethoxamid)、石油(petroleum oils)、甜菜寧(phenmedipham)、胺氯吡啶酸(picloram)、氟吡草胺(picolinafen)、唑啉草酯(pinoxaden)、哌草磷(piperophos)、丙草胺(pretilachlor)、氟嘧磺隆(primisulfuron)、氟嘧磺隆(primisulfuron-methyl)、氨基丙氟靈(prodiamine)、環苯草酮(profoxydim)、撲滅通(prometon)、撲草淨(prometryn)、撲草胺(propachlor)、敵稗(propanil)、噁草酸(propaquizafop)、撲滅津(propazine)、苯胺靈(propham)、異丙草胺(propisochlor)、丙苯磺隆(propoxycarbazone)、丙苯磺隆鈉(propoxycarbazone-sodium)、丙嘧磺隆(propyrisulfuron)、戊炔草胺(propyzamide)、苄草丹(prosulfocarb)、氟磺隆(prosulfuron)、雙唑草腈(pyraclonil)、吡草醚(pyraflufen)、吡草醚(pyraflufen-ethyl)、磺醯草吡唑(pyrasulfotole)、吡唑特(pyrazolynate；pyrazolate)、吡嘧磺隆(pyrazosulfuron)、吡嘧磺隆(pyrazosulfuron-ethyl)、苄草唑(pyrazoxyfen)、草醚(pyribambenz)、異丙酯草醚(pyribambenz-isopropyl)、丙酯草醚(pyribambenz-propyl)、嘧啶肟草醚(pyribenzoxim)、稗草丹(pyributicarb)、吡啶達醇(pyridafol)、噠草特(pyridate)、環酯草醚(pyriftalid)、嘧草醚(pyriminobac)、嘧草醚(pyriminobac-methyl)、嘧啶硫蕃(pyrimisulfan)、嘧硫草醚(pyrithiobac)、嘧硫草醚(pyrithiobac-sodium)、碸吡草唑(pyroxasulfone)、甲氧磺草胺(pyroxsulam)、二氯喹啉酸(quinclorac)、喹草酸(quinmerac)、滅藻醌(quinoclamine)、喹禾靈(quizalofop)、喹禾靈(quizalofop-ethyl)、精喹禾靈(quizalofop-P)、精喹禾靈(quizalofop-P-ethyl)、喹禾糠酯(quizalofop-P-tefuryl)、碸嘧磺隆(rimsulfuron)、苯嘧磺草胺(saflufenacil)、烯禾啶(sethoxydim)、環草隆(siduron)、西瑪津(simazine)、西草淨(simetryn)、SL-261、磺草酮(sulcotrion)、甲磺草胺(sulfentrazone)、甲嘧磺隆(sulfometuron)、甲嘧磺隆(sulfometuron-methyl)、磺醯磺隆(sulfosulfuron)、SYN-523、SYP-249 (亦即1-乙氧基-3-甲基-1-側氧基丁-3-烯-2-基5-[2-氯-4-(三氟甲基)苯氧基]-2-硝基苯甲酸酯)、SYP-300(亦即1-[7-氟基-3-側氧基-4-(丙-2-炔-1-基)-3,4-二氫-2H-1,4-苯并噁嗪-6-基]-3-丙基-2-硫代咪唑啶-4,5-二酮)、2,3,6-TBA、TCA(三氯乙酸)、TCA鈉、得匍隆(tebuthiuron)、特呋喃隆(tefuryltrione)、環磺酮(tembotrione)、吡喃草酮(tepraloxydim)、特草定(terbacil)、特草靈(terbucarb)、甲氧去草淨(terbumeton)、草淨津(terbuthylazin)、去草淨(terbutryn)、甲氧噻草胺(thenylchlor)、噻草定(thiazopyr)、噻酮磺隆(thiencarbazone)、甲酯噻酮磺隆(thiencarbazone-methyl)、噻吩磺隆(thifensulfuron)、甲酯噻吩磺隆(thifensulfuron-methyl)、禾草丹(thiobencarb)、替艾芬斯(tiafenacil)、苯甲醯吡拉(tolpyralate)、苯吡唑草酮(topramezone)、肟草酮(tralkoxydim)、氟酮黃草胺(triafamone)、野麥畏(tri-allate)、醚苯磺隆(triasulfuron)、三嗪氟草胺(triaziflam)、苯磺隆(tribenuron)、甲酯苯磺隆(tribenuron-methyl)、綠草定(triclopyr)、草達津(trietazine)、三氟啶磺隆(trifloxysulfuron)、三氟啶磺隆鈉(trifloxysulfuron-sodium)、三氟草嗪(trifludimoxazin)、氟樂靈(trifluralin)、氟胺磺隆(triflusulfuron)、甲酯氟胺磺隆(triflusulfuron-methyl)、三氟甲磺隆(tritosulfuron)、尿素硫酸鹽(urea sulfate)、滅草猛(vernolate)、XDE-848、ZJ-0862 (亦即，3,4-二氯-N-{2-[(4,6-二甲氧基嘧啶-2-基)氧基]苯甲基}苯胺，及以下化合物：
Figure 02_image075
植物生長調節劑之實例為： 活化酯、活化酯-S-甲基、5-胺基乙醯丙酸、嘧啶醇、6-苯甲基胺基嘌呤、芸苔素內酯(Brassinolid)、兒茶素(catechine)、氯化克美素(chlormequat chloride)、坐果安(cloprop)、環丙酸醯胺(cyclanilide)、3-(環丙-1-烯基)丙酸、丁醯肼(daminozide)、邁隆(dazomet)、正癸醇、敵草克(dikegulac)、敵草克鈉(dikegulac-sodium)、草多索(endothal)、草多索二鉀(endothal-dipotassium)、草多索二鈉及草多索單(N,N-二甲基烷基銨)、益收生長素(ethephon)、氟節胺(flumetralin)、抑草丁(flurenol)、抑草丁丁酯(flurenol-butyl)、調嘧醇(flurprimidol)、氯吡脲(forchlorfenuron)、赤黴酸、依納素(inabenfide)、吲哚-3-乙酸(IAA)、4-吲哚-3-基丁酸、稻瘟靈(isoprothiolane)、撲殺熱、茉莉酸、順丁烯二醯肼、縮節胺(mepiquat chloride)、1-甲基環丙稀、茉莉酸甲酯、2-(1-萘基)乙醯胺、1-萘基乙酸、2-萘氧基乙酸、硝基酚鹽混合物、巴克素(paclobutrazol)、N-(2-苯乙基)-β-丙胺酸、N-苯基鄰胺甲醯苯甲酸、調環酸(prohexadione)、調環酸鈣(prohexadione-calcium)、茉莉酮(prohydrojasmone)、水楊酸、獨腳金內酯(strigolactone)、四氯硝基苯(tecnazene)、噻苯隆(thidiazuron)、三十烷醇(triacontanol)、抗倒酯(trinexapac)、抗倒乙酯(trinexapac-ethyl)、斯脫得(tsitodef)、烯效唑(uniconazole)、烯效唑-P (uniconazole-P)。
方法及用途 式(I)之化合物及包含其之組合物具有強殺微生物活性及/或植物防禦調節潛力。其可用於控制非所需微生物，諸如非所需真菌及細菌。如本文下文中更詳細地描述，其可尤其適用於作物保護(其控制引起植物病害之微生物)或尤其適用於保護材料(例如，工業材料、木材、儲存貨物)。更具體言之，式(I)之化合物及包含其之組合物可用以保護種子、發芽植物、萌芽苗木、植物、植物部分、果實、收穫物及/或植物生長之土壤免受非所需微生物傷害。
如本文所用，控制(control/controlling)涵蓋不合需要之微生物之保護性、治癒性及根除性處理。非所需微生物可為病原性細菌、病原性病毒、病原性卵菌或病原性真菌，更具體言之可為植物病原性細菌、植物病原性病毒、植物病原性卵菌或植物病原性真菌。如本文下文中所詳細描述，此等植物病原性微生物係廣泛範圍之植物病害之致病原因。
更特定言之，式(I)之化合物及包含其之組合物可用作殺真菌劑。出於本說明書之目的，術語「殺真菌劑」係指可用於作物保護以供控制非所需真菌(諸如根腫菌(Plasmodiophoromycetes)、壺菌(Chytridiomycetes)、接合菌(Zygomycetes)、子囊菌(Ascomycetes)、擔子菌(Basidiomycetes)及半知菌(Deuteromycetes))及/或控制卵菌(Oomycetes)的化合物或組合物。
式(I)之化合物及包含其之組合物亦可用作抗細菌劑。詳言之，其可適用於作物保護，例如用於控制非所需細菌，諸如假單胞菌科、根瘤菌科、黃單胞菌科、腸內菌科、棒狀桿菌科及鏈絲菌科。
式(I)之化合物及包含其之組合物亦可用作作物保護中的抗病毒劑。舉例而言，式(I)化合物及包含其之組合物可對植物病毒引起之病害有效，該等植物病毒諸如菸草嵌紋病毒(TMV)、菸草脆裂病毒(tobacco rattle virus)、菸草矮化病毒(TStuV)、菸草卷葉病毒(VLCV)、菸草脈葉藍嵌紋病毒(TVBMV)、菸草壞死性矮縮病毒(TNDV)、菸草條紋病毒(TSV)、馬鈴薯病毒X (PVX)、馬鈴薯病毒Y、馬鈴薯病毒S、馬鈴薯病毒M及馬鈴薯病毒A、馬鈴薯奧古巴嵌紋病毒(potato acuba mosaic virus；PAMV)、馬鈴薯帚頂病毒(PMTV)、馬鈴薯卷葉病毒(PLRV)、苜蓿花葉病毒(AMV)、胡瓜嵌紋病毒(CMV)、胡瓜綠色斑駁花葉病毒(CGMMV)、胡瓜黃化病毒(CuYV)、西瓜嵌紋病毒(WMV)、番茄斑萎病毒(TSWV)、番茄輪點病毒(TomRSV)、甘蔗嵌紋病毒(SCMV)、水稻矮縮病毒、水稻條斑病毒、水稻黑條矮縮病毒、草莓斑紋病毒(SMoV)、草莓鑲脈病毒(SVBV)、草莓輕度黃邊病毒(SMYEV)、草莓連葉病毒(SCrV)、蠶豆萎凋病毒(BBWV)及甜瓜壞死性斑點病毒(MNSV)。
本發明亦關於一種用於控制非所需微生物，諸如非所需真菌、卵菌及細菌之方法，該方法包含以下步驟：將至少一種式(I)化合物或至少一種組合物施加至微生物及/或其生境(施加至植物、植物部分、種子、果實或施加至植物生長的土壤)。
通常，當式(I)之化合物及包含其之組合物用於治癒性或保護性方法以控制植物病原性真菌及/或植物病原性卵菌時，將其有效量及植物可相容量施加至植物、植物部分、果實、種子或施加至植物生長的土壤或基質。可用於培育植物之適合基質包括基於無機物之基質，諸如礦棉，尤其岩棉、珍珠岩、砂或礫石；有機基質，諸如泥炭、松樹皮或鋸屑；及基於石油之基質，諸如聚合泡沫或塑料珠粒。有效量及植物可相容量 意謂足以控制或毀壞耕地上存在或易在耕地上出現的真菌，且不會引起該等作物之任何顯著的植物毒性症狀。視待控制之真菌、作物類型、作物生長階段、氣候條件及所用之各別式(I)化合物或組合物而定，此類量可在廣泛圍內變化。此量可藉由熟習此項技術者能力範圍內之系統田間試驗來測定。
植物及植物部分 式(I)之化合物及包含其之組合物可施加於任何植物或植物部分。
植物 意謂所有植物及植物群體，諸如所需及不合需要之野生植物或作物植物(包括天然產生之作物植物)。作物植物可為藉由習知育種及最佳化方法或藉由生物技術及基因工程方法或此等方法之組合可獲得的植物，包括經基因修飾之植物(GMO或轉殖基因植物)及可受及不受植物育種者權利保護的植物栽培品種。
經基因修飾之植物 ( GMO ) 經基因修飾之植物(GMO或轉殖基因植物)為異源基因已穩定整合於基因組中之植物。表述「異源基因」基本上意謂在植物外部且在引入核、葉綠體或粒線體基因組中時提供或組裝的基因。此基因藉由表現相關蛋白質或多肽或藉由下調或抑制植物中存在之其他基因(使用例如反義技術、共抑制技術、RNA干擾-RNAi技術或微RNA-miRNA技術)賦予轉化植物新的或改良的農藝特性或其他特性。位於基因組中之異源基因亦稱為轉基因。由在植物基因組中之特定位置定義之轉殖基因稱為轉化或轉殖基因事件。
應將植物栽培品種 理解為意謂具有新型特性(「性狀」)且已藉由習知育種、藉由誘變或藉由重組DNA技術獲得之植物。其可為栽培品種、變種、生物型或基因型。
植物部分 應理解為意謂地上及地下之植物的所有部分及器官，諸如幼芽、葉片、針葉、莖梗(stalk)、莖稈(stem)、花朵、子實體、果實、種子、根部、塊莖及根莖。植物部分亦包括收穫之物質及無性與有性繁殖物質，例如插條、塊莖、根莖、幼枝及種子。
可根據本文所描述之方法處理之植物包括以下：棉花、亞麻、葡萄藤、水果、蔬菜，諸如薔薇科(Rosaceae sp . ) (例如，仁果，諸如蘋果及梨，而且例如核果，諸如杏、杏仁及桃，以及無核小水果，諸如草莓)、茶藨子科(Ribesioidae sp . )、胡桃科(Juglandaceae sp . )、樺科(Betulaceae sp .) 、漆樹科(Anacardiaceae sp . )、山毛櫸科(Fagaceae sp . )、桑科(Moraceae sp . )、木樨科(Oleaceae sp . )、獼猴桃科(Actinidaceae sp . )、樟科(Lauraceae sp . )、芭蕉科(Musaceae sp . ) (例如，香蕉樹及人造林)、茜草科(Rubiaceae sp . ) (例如咖啡)、茶科(Theaceae sp . )、梧桐科(Sterculiceae sp . )、Rutaceae sp . (芸香科)(例如，檸檬、柑橘及葡萄柚)；茄科(Solanaceae sp . )(例如蕃茄)、百合科(Liliaceae sp . )、菊科(Asteraceae sp . )(例如萵苣)、傘形科(Umbelliferae sp . )、十字花科(Cruciferae sp . )、藜科(Chenopodiaceae sp . )、葫蘆科(Cucurbitaceae sp . )(例如胡瓜)、蔥科(Alliaceae sp . )(例如韭菜、洋蔥)、蝶形花科(Papilionaceae sp . )(例如豆類)；長軸作物植物，諸如禾本科(Gramineae sp . )(例如，玉米、草皮、穀類，諸如小麥、粗麥、稻穀、大麥、燕麥、栗及黑小麥)、菊科(Asteraceae sp . )(例如葵花)、十字花科(Brassicaceae sp . )(例如白球甘藍、紅球甘藍、椰菜、花椰菜、孢子甘藍、白菜、球莖甘藍、蘿蔔及油菜、芥菜、辣根及水芹)、豆科(Fabacae sp . ) (例如，豆子、花生)、蝶形花科(Papilionaceae sp . )(例如大豆)、茄科(Solanaceae sp . )(例如馬鈴薯)、藜科(Chenopodiaceae sp . ) (例如糖用甜菜、飼用甜菜、紅頭菜、甜菜根)；供園林及林地用之有用植物及觀賞性植物；及此等植物中之每一者的經基因修飾之變體。
可藉由上文所揭示之方法處理之植物及植物栽培品種包括抗一或多種生物性逆境的植物及植物栽培品種，亦即，該等植物展示對動物及微生物害蟲之更佳防禦，諸如抵抗線蟲、昆蟲、蟎、植物病原性真菌、細菌、病毒及/或類病毒。
可藉由上文所揭示之方法處理之植物及植物栽培品種包括抗一或多種非生物性逆境的彼等植物。非生物性逆境條件可包括例如乾旱、低溫暴露、熱暴露、滲透壓力、洪水、增加之土壤鹽度、增加之礦物質暴露、臭氧暴露、高光暴露、氮養分之有限可用性、磷養分之有限可用性、避蔭。
可藉由上文所揭示之方法處理之植物及植物栽培品種包括特徵為產量特徵增強之彼等植物。該等植物之產量增加可為例如改良植物生理學、生長及發育(諸如水利用效率、水保持效率、改良氮使用、增強碳同化、改良光合成、增加發芽效率及加快成熟)之結果。產量可另外受改良之植物株型影響(在逆境及非逆境條件下)，該改良之植物株型包括但不限於早期開花、對雜交種子生產之開花控制、幼苗活力、植物大小、節間數目及距離、根生長、種子大小、果實大小、豆莢大小、豆莢或穗數目、每個豆莢或穗之種子數目、種子質量、增強之種子填充、降低之種子散佈度、降低之豆莢開裂性及抗倒伏性。其他產量性狀包括種子組合物，諸如，碳水化合物含量及例如棉或澱粉之組合物、蛋白質含量、油含量及組成、營養值、反側營養化合物之還原、經改良可加工性及更佳儲存穩定性。
可藉由上文所揭示之方法處理之植物及植物栽培品種包括為雜交植物之植物及植物栽培品種，該等雜交植物已表現大體上引起較高產量、活力、健康及抗生物及非生物逆境之雜種優勢或雜交活力的特性。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術方法獲得)包括為除草劑耐受性植物之植物及植物栽培品種，亦即對一或多種給定除草劑耐受的植物。此類植物可藉由遺傳轉化或藉由選擇含有賦予此類除草劑耐受性之突變之植物獲得。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術方法獲得)包括為昆蟲抗性轉殖基因植物之植物及植物栽培品種，亦即對某些靶標昆蟲之攻擊具有抗性的植物。此類植物可藉由遺傳轉化或藉由選擇含有賦予此類耐昆蟲性之突變之植物獲得。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術方法獲得)包括為病害抗性轉殖基因植物之植物及植物栽培品種，亦即對某些目標昆蟲之攻擊具有抗性的植物。此類植物可藉由遺傳轉化或藉由選擇含有賦予此類耐昆蟲性之突變之植物獲得。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術獲得)包括對非生物逆境耐受之植物及植物栽培品種。此類植物可藉由遺傳轉化或藉由選擇含有賦予此類逆境耐受性之突變之植物獲得。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之生物技術方法獲得)包括展示更改所收穫產物之數量、品質及/或儲存穩定性及/或更改所收穫產物之特定成分之特性的植物及植物栽培品種。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術方法獲得)包括具有經更改纖維特徵之植物及植物栽培品種(諸如，棉植物)。此類植物可藉由基因轉型或藉由選擇含有賦予此類經更改纖維特徵之突變之植物獲得。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術方法獲得)包括具有經更改出油概況特徵之植物及植物栽培品種，諸如油菜或相關甘藍型植物。此類植物可藉由基因轉型或藉由選擇含有賦予此類經更改油型態特徵之突變之植物來獲得。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術方法獲得)包括具有經更改落粒性特徵之植物及植物栽培品種，諸如油菜或相關甘藍型植物。此類植物可藉由基因轉型或藉由選擇含有賦予此類經更改落粒性特徵之突變之植物來獲得，且包括具有延時或經降低落粒性之植物，諸如油菜植物。
可藉由上文所揭示之方法處理之植物及植物栽培品種(藉由諸如基因工程之植物生物技術方法獲得)包括具有經更改轉譯後蛋白修飾模式之植物及植物栽培品種，諸如菸草植物。
病原體
可根據本發明治療之真菌性病害之病原體的非限制性實例包括： 由白粉病病原體引起之病害，該等白粉病病原體例如：白粉病菌屬(Blumeria species)，例如禾本科布氏白粉菌(Blumeria graminis )；叉絲單囊殼屬(Podosphaera species)，例如白叉絲單囊殼(Podosphaera leucotricha )；單絲殼屬(Sphaerotheca species)，例如單絲殼白粉菌(Sphaerotheca fuliginea )；鉤絲殼屬(Uncinula species)，例如葡萄白粉病菌(Uncinula necator )； 由銹病病原體引起之病害，該等銹病病原體例如：膠鏽菌屬(Gymnosporangium species)，例如褐色膠鏽菌(Gymnosporangium sabinae )；駝孢鏽菌屬(Hemileia species)，例如咖啡駝孢鏽菌(Hemileia vastatrix)；層鏽菌屬(Phakopsora species)，例如大豆鏽菌(Phakopsora pachyrhizi )或層鏽層假尾孢菌(Phakopsora meibomiae )；柄鏽菌屬(Puccinia species)，例如麥類葉銹病菌(Puccinia recondita )、禾柄鏽菌奧德條形柄鏽菌(Puccinia graminis oder Puccinia striiformis)；單孢鏽菌屬(Uromyces species)，例如菜豆銹病菌(Uromyces appendiculatus )； 由來自卵菌之群的病原體引起之病害，該等病原體例如：白銹病屬(Albugo species)，例如白鏽菌(Albugo candida )；萵苣露菌病菌屬(Bremia species)，例如萵苣露菌病(Bremia lactucae )；霜黴菌屬(Peronospora species)，例如豌豆霜黴菌(Peronospora pisi )或芸苔根腫菌(P . brassicae )；疫黴菌屬(Phytophthora species)，例如致病疫黴(Phytophthora infestans )；單軸黴屬(Plasmopara species)，例如葡萄生單軸黴(Plasmopara viticola )；假霜黴屬(Pseudoperonospora species)，例如葎草假霜黴(Pseudoperonospora humuli )或古巴假霜黴菌(Pseudoperonospora cubensis )；腐黴菌屬(Pythium species)，例如終極腐黴菌(Pythium ultimum )； 由例如以下引起之葉斑病及葉萎病：交鏈孢屬(Alternaria species)，例如立枯交鏈孢(Alternaria solani )；尾孢菌屬(Cercospora species)，例如甜菜尾孢菌(Cercospora beticola )；黑星病菌屬(Cladiosporium species)，例如黃瓜黑星病菌(Cladiosporium cucumerinum )；旋孢腔菌屬(Cochliobolus species)，例如禾旋孢腔菌(Cochliobolus sativus) (分生孢子形式：內臍蠕孢屬(Drechslera )，同義詞：長蠕孢(Helminthosporium ))或宮部旋孢腔菌(Cochliobolus miyabeanus )；刺盤孢屬(Colletotrichum species)，例如菜豆炭疽病菌(Colletotrichum lindemuthanium )；棒孢黴屬(Corynespora species)，例如多主棒孢黴(Corynespora cassiicola )；孔雀斑菌屬(Cycloconium species)，例如油橄欖孔雀斑菌(Cycloconium oleaginum )；黑點病菌屬(Diaporthe species)，例如柑橘黑點病菌(Diaporthe citri )；痂囊腔菌屬(Elsinoe species)，例如柑桔痂囊腔菌(Elsinoe fawcettii )；炭疽病菌屬(Gloeosporium species)，例如桃炭疽病菌(Gloeosporium laeticolor)；小叢殼屬(Glomerella species)，例如圍小叢殼菌(Glomerella cingulata )；球座菌屬(Guignardia species)，例如葡萄球座菌(Guignardia bidwelli )；小球腔菌屬(Leptosphaeria species)，例如十字花科小球腔菌(Leptosphaeria maculans )；稻瘟菌屬(Magnaporthe species)，例如稻瘟菌(Magnaporthe grisea )；微結節菌屬(Microdochium species)，例如雪黴枯葉病菌(Microdochium nivale )；球腔菌屬(Mycosphaerella species)，例如禾生球腔菌(Mycosphaerella graminicola )、落花生球腔菌(Mycosphaerella arachidicola )或斐濟球腔菌(Mycosphaerella fijiensis )；暗球腔菌屬(Phaeosphaeria species)，例如小麥葉枯病菌(Phaeosphaeria nodorum )；核腔菌屬(Pyrenophora species)，例如大麥網斑病菌(Pyrenophora teres )或偃麥草核腔菌(Pyrenophora tritici repentis )；柱隔孢屬(Ramularia species)，例如柱隔孢(Ramularia collo-cygni)或白斑柱隔孢；雲紋病菌屬(Rhynchosporium species)，例如大麥雲紋病菌(Rhynchosporium secalis )；殼針孢屬(Septoria species)，例如芹菜小殼針孢(Septoria apii )或番茄殼針孢(Septoria lycopersici )；殼多孢屬(Stagonospora species)，例如穎枯殼針孢(Stagonospora nodorum )；核瑚菌屬(Typhula species)，例如肉孢核瑚菌(Typhula incarnata )；黑星菌屬(Venturia species)，例如蘋果黑星病菌(Venturia inaequalis )； 由例如以下引起之根部及莖稈病害：伏革菌屬(Corticium species)，例如禾穀鐮孢伏革菌(Corticium graminearum )；鐮菌屬(Fusarium species)，例如尖孢鐮刀菌(Fusarium oxysporum )；頂囊殼屬(Gaeumannomyces species)，例如禾草頂囊殼菌(Gaeumannomyces graminis )；根腫菌屬(Plasmodiophora species)，例如甘藍根腫菌(Plasmodiophora brassicae )；絲核菌屬(Rhizoctonia species)，例如立枯絲核菌(Rhizoctonia solani )；帚枝黴屬(Sarocladium species)，例如稻葉鞘腐敗病菌(Sarocladium oryzae )；小核菌屬(Sclerotium species)，例如稻小核菌(Sclerotium oryzae )；塔普斯菌屬(Tapesia species)，例如塔普斯梭狀芽胞桿菌(Tapesia acuformis )；根串珠黴屬(Thielaviopsis species)，例如菫菜根腐病菌(Thielaviopsis basicola )； 由例如以下引起之穗及圓錐花序病害(包括玉米穗軸)：交鏈孢屬(Alternaria species)，例如交鏈孢菌(Alternaria spp . )；麴菌屬(Aspergillus species)，例如黃麴菌(Aspergillus flavus )；分枝孢子菌屬(Cladosporium species)，例如芽枝狀枝孢黴(Cladosporium cladosporioides )；麥角菌屬(Claviceps species)，例如紫黑麥角菌(Claviceps purpurea )；鐮菌屬(Fusarium species)，例如黃色鐮孢菌(Fusarium culmorum )；赤黴菌屬(Gibberella species)，例如玉米赤黴(Gibberella zeae )；小畫線殼屬(Monographella species)，例如雪黴小畫線殼(Monographella nivalis )；殼多孢菌屬(Stagnospora species)，例如穎枯殼針孢(Stagonospora nodorum )； 由黑穗病真菌引起之病害，該等黑穗病真菌例如：蜀黍小黑穗病菌屬(Sphacelotheca species)，例如高粱絲黑粉菌(Sphacelotheca reiliana )；腥黑粉菌屬(Tilletia species)，例如小麥矮腥黑粉菌(Tilletia caries 或Tilletia controversa)；條黑粉菌屬(Urocystis species)，例如隱條黑粉菌(Urocystis occulta )；黑粉菌屬(Ustilago species)，例如麥散黑粉菌(Ustilago nuda )； 由例如以下引起之果腐病：麴菌屬(Aspergillus species)，例如黃麴菌(Aspergillus flavus )；葡萄孢屬(Botrytis species)，例如灰葡萄孢菌(Botrytis cinerea )；鏈核盤菌屬(Monilinia species)，例如拉克撒鏈核盤菌(Monilinia laxa )；青黴菌屬(Penicillium species)，例如擴展青黴(Penicillium expansum )或產紫青黴(Penicillium purpurogenum )；根黴菌屬(Rhizopus species)，例如匍枝根黴(Rhizopus stolonifer )；核盤菌屬(Sclerotinia species)，例如向日葵核盤菌(Sclerotinia sclerotiorum )；輪枝孢屬(Verticilium species)，例如黃萎輪枝黴(Verticilium alboatrum )； 種子及土壤媒介腐病及萎病以及由例如以下引起之苗木病害：交鏈孢屬，例如甘藍交鏈孢黴(Alternaria brassicicola )；絲囊黴屬(Aphanomyces species)，例如兵豆絲囊黴(Aphanomyces euteiches )；殼二孢屬(Ascochyta species)，例如晶狀殼二孢(Ascochyta lentis )；麴菌屬，例如黃麴菌；分枝孢子菌屬，例如多主枝孢黴(Cladosporium herbarum )；旋孢腔菌屬，例如禾旋孢腔菌(分生孢子形式：內臍蠕孢屬，同義詞：長蠕孢)；刺盤孢屬，例如仙人掌炭疽刺盤孢菌(Colletotrichum coccodes )；鐮菌屬，例如黃色鐮孢菌；赤黴菌屬，例如玉米赤黴；殼球孢屬(Macrophomina species)，例如萊豆殼球孢(Macrophomina phaseolina )；微結節菌屬，例如雪黴枯葉病菌；小畫線殼屬，例如雪黴小畫線殼；青黴菌屬，例如擴展青黴；莖點黴屬(Phoma species)，例如黑脛莖點黴(Phoma lingam )；擬莖點黴屬(Phomopsis species)，例如大豆擬莖點黴；疫黴菌屬(Phytophthora species)，例如惡疫黴(Phytophthora cactorum )；核腔菌屬，例如大麥核腔菌；梨孢屬(Pyricularia species)，例如稻梨孢(Pyricularia oryzae )；腐黴菌屬，例如終極腐黴菌；絲核菌屬，例如立枯絲核菌；根黴菌屬，例如酒麴菌；小核菌屬，例如白絹病小核菌(Sclerotium rolfsii )；殼針孢屬，例如穎枯殼針孢；核瑚菌屬，例如內孢核瑚菌；輪枝菌屬，例如大麗花輪枝孢； 由例如以下引起之癌症、蟲癭及叢枝病：叢赤殼屬(Nectria species)，例如，仁果幹癌叢赤殼(Nectria galligena )； 由例如以下引起之萎病：輪枝菌屬，例如長孢輪枝菌(Verticillium longisporum )；鐮菌屬，例如尖孢鐮刀菌； 由例如以下引起之葉片、花及果實之畸形：外擔菌屬(Exobasidium species)，例如，壞損外擔菌(Exobasidium vexans )；外囊菌屬(Taphrina species)，例如，畸形外囊菌(Taphrina deformans )； 由例如以下引起之木本植物之退行性病害：埃斯卡屬(Esca species)，例如，根黴格孢菌(Phaeomoniella chlamydospora)、褐枝頂孢黴(Phaeoacremonium aleophilum)或地中海嗜藍孢孔菌(Fomitiporia mediterranea)；靈芝屬(Ganoderma species)，例如，島靈芝(Ganoderma boninense )； 由以下引起之植物塊莖之病害：絲核菌屬(Rhizoctonia species)，例如，立枯絲核菌(Rhizoctonia solani )；長蠕孢屬，例如，立枯長蠕孢菌； 由細菌性病原體引起之病害，該等細菌性病原體例如黃單孢菌屬(Xanthomonas species)，例如野油菜黃單胞菌(Xanthomonas campestris pv . oryzae )；假單胞菌屬，例如甜瓜細菌性葉斑病菌(Pseudomonas syringae pv . lachrymans )；歐文菌屬(Erwinia species)，例如解澱粉歐文菌(Erwinia amylovora )；黃龍病菌屬(Liberibacter species)，例如柑橘黃龍病(Liberibacter asiaticus )；變形菌屬(Xyella species)，例如葉緣焦枯病菌(Xylella fastidiosa )；羅爾斯頓菌屬(Ralstonia species)，例如茄科羅爾斯頓菌(Ralstonia solanacearum )；基氏菌屬(Dickeya species)，例如立枯基氏菌(Dickeya solani )；棍狀桿菌屬，例如密執安棍狀桿菌(Clavibacter michiganensis )；鏈黴菌屬，例如疥鏈黴菌(Streptomyces scabies )。
大豆病害：
由例如以下引起的葉片、莖稈、豆莢及種子之真菌性病害：交鏈孢屬葉斑病(細極交鏈孢黴；Alternaria spec . atrans tenuissima )，炭疽病(赤葉枯刺盤孢菌變種；Colletotrichum gloeosporoides dematium var . truncatum )，褐斑病(大豆褐紋殼針孢；Septoria glycines )，尾孢菌葉斑病及枯萎病(菊池尾孢菌；Cercospora kikuchii )，笄黴屬葉枯病(漏斗笄黴菌；Choanephora infundibulifera trispora (同義))，dactuliophora 葉斑病(Dactuliophora 甘胺酸)，霜黴病(東北霜黴；Peronospora manshurica )，內臍蠕孢枯萎病(格利思尼內臍蠕孢；Drechslera glycini )，辣椒葉斑病(大豆灰斑病菌)，小光腔菌葉斑病(三葉草小光腔菌；Leptosphaerulina trifolii )，葉點黴葉斑病(大豆生葉點黴；Phyllosticta sojaecola )，豆莢及莖稈枯萎病(大豆擬莖點黴)，白粉病(白粉病菌；Microsphaera diffusa )，鬚殼孢葉斑病(鬚殼孢甘胺酸)，絲核菌氣根、葉及網脈枯萎病(立枯絲核菌；Rhizoctonia solani )，銹病(大豆鏽菌(Phakopsora pachyrhizi )、層鏽層假尾孢菌(Phakopsora meibomiae ))，瘡斑病(痂圓孢菌甘胺酸)，匍柄黴葉枯病(匍柄黴；Stemphylium botryosum )，猝死症(棒形鐮刀菌；Fusarium virguliforme )，靶斑病(多主棒孢黴；Corynespora cassiicola )。
由例如以下引起之根及莖基部真菌性病害：黑根腐病(野百合尾孢菌(Calonectria crotalariae ))、炭腐病(菜豆立枯病菌(Macrophomina phaseolina ))、鐮菌枯萎病或萎蔫病、根腐病以及豆莢及根頸腐病(尖孢鐮刀菌(Fusarium oxysporum )、直喙鐮孢(Fusarium orthoceras )、半裸鐮孢(Fusarium semitectum )、木賊鐮孢(Fusarium equiseti ))、細圓盤黴根腐病(褐紅壞死病病菌(Mycoleptodiscus terrestris ))、赤殼菌(neocosmospora)(侵菅新赤殼菌(Neocosmospora vasinfecta ))、豆莢及莖稈枯萎病(大豆黑點病菌(Diaporthe phaseolorum ))、莖潰瘍(大豆黑點病菌變種(Diaporthe phaseolorum var . caulivora ))、疫黴菌腐病(大雄疫黴菌(Phytophthora megasperma ))、褐莖腐病(大豆莖褐腐病菌(Phialophora gregata ))、腐黴菌腐病(瓜果腐黴Pythium aphanidermatum )、畸雌腐黴(Pythium irregulare )、德巴利腐黴(Pythium debaryanum )、群結腐黴(Pythium myriotylum )、終極腐黴(Pythium ultimum ))、絲核菌根腐病(rhizoctonia root rot)、莖腐病及猝倒病(立枯絲核菌(Rhizoctonia solani ))、核盤菌莖腐病(向日葵核盤菌(Sclerotinia sclerotiorum ))、核盤菌白絹病(白絹病核盤菌(Sclerotinia rolfsii ))、根串珠黴根腐病(菫菜根腐病菌(Thielaviopsis basicola ))。
黴菌毒素
另外，式(I)之化合物及包含其之組合物可降低所收穫物質及自其製備之食品與飼料中之徵菌毒素含量。黴菌毒素尤其但非排他地包括以下：脫氧雪腐鐮刀菌烯醇(deoxynivalenol) (DON)、雪腐鐮刀菌醇(nivalenol)、15-Ac-DON、3-Ac-DON、T2-毒素及HT2-毒素、伏馬菌素(fumonisins)、玉米赤黴烯酮(zearalenon)、串珠鐮刀菌素(moniliformin)、鐮刀菌素(fusarin)、蛇形菌素(diaceotoxyscirpenol) (DAS)、白僵菌素(beauvericin)、恩鐮孢菌素(enniatin)、福撒羅多育麴菌素(fusaroproliferin)、福撒羅菌素(fusarenol)、赭麯黴素(ochratoxins)、散毒素(patulin)、麥角生物鹼(ergot alkaloid)及黃麴黴毒素(aflatoxins)，其可例如藉由以下真菌產生：鐮刀菌屬(Fusarium spec . )，諸如銳頂鐮刀菌(F . acuminatum )、亞洲鐮刀菌(F . asiaticum )、燕麥鐮刀菌(F . avenaceum )、克地鐮刀菌(F . crookwellense )、黃色鐮刀菌(F . culmorum )、禾穀鐮刀菌(F . graminearum ) (玉米赤黴菌(Gibberella zeae ))、木賊鐮刀菌(F . equiseti )、水稻鐮刀菌(F . fujikoroi )、香蕉鐮刀菌(F . musarum )、尖鐮孢菌(F . oxysporum )、串珠鐮刀菌(F . proliferatum )、梨孢鐮刀菌(F . poae )、小麥莖基腐病菌假禾穀鐮刀菌(F . pseudograminearum )、接骨木鐮刀菌(F . sambucinum )、蕉草鐮刀菌(F . scirpi )、半裸鐮刀菌(F . semitectum )、立枯鐮刀菌(F . solani )、擬枝孢鐮刀菌(F . sporotrichoides )、穀物鐮刀菌(F . langsethiae )、膠孢鐮刀菌(F . subglutinans )、三線鐮刀菌(F . tricinctum )、輪枝樣鐮刀菌(F . verticillioides )等，以及藉由以下產生：麴菌屬(Aspergillus spec . )，諸如黃麴菌(A . flavus )、寄生麴菌(A . parasiticus )、稻米麴菌(A . nomius )、赭麯黴(A . ochraceus )、棒麯黴(A . clavatus )、土麴菌(A . terreus )、雜色麯黴(A . versicolor )，青黴菌屬(Penicillium spec . )，諸如疣孢青黴菌(P . verrucosum )、鮮綠青黴菌(P . viridicatum )、桔青黴(P . citrinum )、擴展青黴(P . expansum )、棒狀青黴(P . claviforme )、洛克福耳青黴菌(P . roqueforti )，麥角菌屬(Claviceps spec . )，諸如菊麥角菌(C . purpurea )、紡綞形麥角菌(C . fusiformis )、雀稗麥角菌(C . paspali )、非洲麥角菌(C . africana )，葡萄穗黴菌屬(Stachybotrys spec . )及其他。
物質保護
式(I)之化合物及包含其之組合物亦可用於保護物質，尤其用於保護抗植物病原性真菌之攻擊及破壞的工業物質。
另外，式(I)之化合物及包含其之組合物可單獨或與其他活性成份組合用作防污組合物。
本上下文中的工業材料 應理解為意謂已經製備以用於工業中的非生物材料。舉例而言，欲保護以免受微生物改變或破壞之工業物質可為黏著劑、膠、紙張、牆紙及紙板/卡紙板、紡織物、地毯、皮革、原木、纖維及紙巾、塗料及塑膠製品、冷卻潤滑劑以及可受微生物影響或破環之其他物質。亦可在欲保護之材料的範疇內提及可被微生物之增殖減弱的生產設備及建築物之部分(例如水冷卻電路、冷卻及加熱系統以及通風及空調單元)。本發明範疇內之工業材料較佳地包括黏著劑、膠料、紙張及卡片、皮革、原木、塗料、冷卻潤滑劑及熱傳遞流體，更佳地原木。
式(I)之化合物及包含其之組合物可防止有害影響，諸如腐壞、腐爛、變色、脫色或黴形成。
就原木處理而言，式(I)之化合物及包含其之組合物亦可用以抵抗易在木材上或內部生長之真菌性病害。
木材 意謂所有類型之原木物種，及欲用於建築之此原木之所有加工類型，例如實心原木、高密度原木、層壓原木板及膠合板。另外，式(I)之化合物及包含其之組合物可用以保護與鹽水或微咸水形成接觸之物件(尤其為皮、螢幕、網、建築物、繫泊船及信號傳導系統)免受積垢。
式(I)之化合物及包含其之組合物亦可用於保護儲存貨物。應將儲存貨物理解為意謂蔬菜或動物來源之天然物質或其經處理產品，其具有天然來源且需要長期保護。蔬菜來源之儲存貨物(例如植物或植物部分，諸如莖稈、葉片、塊莖、種子、果實、穀粒)可在剛收穫後或在藉由(預)乾燥、濕潤、粉碎、研磨、按壓或焙烤之處理後受到保護。儲存貨物亦包括木材，其未經處理(諸如建築木材、電線桿及障壁)或呈成品形式(諸如傢俱)。動物來源之儲存貨物係例如獸皮、皮革、皮草及毛髮。式(I)之化合物及包含其之組合物可防止有害影響，諸如腐壞、腐爛、變色、脫色或黴形成。
能夠降解或改變工業物質之微生物包括(例如)細菌、真菌、酵母、藻類及黏液生物生物體。式(I)之化合物及包含其之組合物較佳地針對真菌，尤其黴菌、使原木變色及毀壞原木之真菌(子囊菌、擔子菌、半知菌及接合菌)，以及針對黏液生物體及藻類起作用。實例包括以下屬之微生物：交鏈孢屬，諸如美洲留蘭香交鏈孢屬(Alternaria tenuis )；麴菌屬，諸如黑麯黴(Aspergillus niger )；毛殼菌屬(Chaetomium )，諸如球毛殼菌屬(Chaetomium globosum )；粉孢革菌屬(Coniophora )，諸如單純粉孢革菌屬(Coniophora puetana )；香菇屬(Lentinus )，諸如虎皮香菇屬(Lentinus tigrinus )；青黴菌屬，諸如灰綠青黴菌(Penicillium glaucum )；多孔菌屬(Polyporus )，諸如變色多孔菌(Polyporus versicolor )；短梗黴屬(Aureobasidium )，諸如出芽短梗黴菌(Aureobasidium pullulans )；核莖點黴屬(Sclerophoma )，諸如綠頂核莖點黴(Sclerophoma pityophila )；木黴菌屬(Trichoderma )，諸如綠色木黴菌屬(Trichoderma viride )；長喙殼菌(Ophiostoma spp . )；長喙殼屬(Ceratocystis spp . )；腐殖菌屬(Humicola spp . )；石座菌屬(Petriella spp . )；毛束黴屬(Trichurus spp .) ；革蓋菌屬(Coriolus spp . )；黏褶菌屬(Gloeophyllum spp . )；側耳屬(Pleurotus spp . )；臥孔菌屬(Poria spp . )；蟠龍介屬(Serpula spp . )及乾酪菌屬(Tyromyces spp . )；分枝孢子菌屬(Cladosporium spp . )；擬青黴菌屬(Paecilomyces spp . )；白黴菌屬(Mucor spp . )；埃希氏桿菌屬(Escherichia )，諸如大腸桿菌(Escherichia coli )；假單胞菌屬(Pseudomonas )，諸如綠膿桿菌(Pseudomonas aeruginosa )；葡萄球菌屬(Staphylococcus )，諸如金黃色葡萄球菌(Staphylococcus aureus )；念珠菌屬(Candida spp . )及酵母屬(Saccharomyces spp .)，諸如釀酒酵母(Saccharomyces cerevisae )。
種子處理 式(I)之化合物及包含其之組合物亦可用以保護種子免受非所需微生物影響，諸如植物病原性微生物，例如植物病原性真菌或植物病原性卵菌。如本文所用，術語種子 包括休眠種子、引發種子、預發芽種子及具有冒出之根及葉片之種子。
因此，本發明亦關於一種用於保護種子免受非所需微生物影響之方法，其包含以下步驟：用式(I)之化合物或組合物處理種子。
用式(I)之化合物或組合物處理種子，保護種子免受植物病原性微生物影響，而且保護萌發種子、所冒出幼苗木及自經處理種子冒出後之植物。因此，本發明亦係關於一種用於保護種子、萌發種子且使幼苗冒出之方法。
種子處理可在播種之前、播種時或播種不久後進行。
當在播種前進行種子處理(例如，所謂的種子上施加)時，可如下進行種子處理：可將種子置放於具有所需量之式(I)之化合物或組合物之混合器中，混合種子及式(I)之化合物或組合物直至實現種子上之均勻分佈為止。適當時，可隨後乾燥種子。
本發明亦關於塗佈有式(I)之化合物或包含其之組合物的種子。
較佳地，種子在處理過程中不出現損害之足夠穩定之狀態下進行處理。一般而言，種子可在收穫與播種後不久之間的任何時間進行處理。習用使用已自植物分離且自穗軸、殼、梗、外殼、毛髮或果實之果肉釋放的種子。舉例而言，有可能使用已收穫、清潔及經乾燥至水分含量降至小於15重量%的種子。或者，亦有可能使用在乾燥之後例如已用水處理且隨後再次乾燥的種子、或剛好引發後之種子、或儲存於引發條件下之種子或預發芽種子、或在育苗盤、膠帶或紙張上播種之種子。
施加至種子之式(I)之化合物或包含其之組合物之量通常使得種子發芽不減弱或所得植物不損害。此必須特別地確定，以防式(I)之化合物在某些施加量下將呈現植物毒性效果。在判定待施加至種子以便用最少量的所用化合物達成最佳種子及發芽植物保護的式(I)化合物的量時，亦應考量轉殖基因植物之固有表型。
式(I)之化合物可原樣直接施加至種子，亦即無需使用任何其他組分且無需稀釋。包含其之組合物亦可施加至種子。
式(I)之化合物及包含其之組合物適合於保護任何植物品種之種子。較佳種子為穀類(諸如，小麥、大麥、粗麥、栗、黑小麥及燕麥)、油菜、玉米、棉、大豆、水稻、馬鈴薯、向日葵、菜豆、咖啡、豆類、甜菜(例如，糖用甜菜及飼料甜菜)、花生、蔬菜(諸如，番茄、胡瓜、洋蔥及萵苣)、草坪及觀賞植物。更佳的為小麥、大豆、油菜、玉米及水稻之種子。
式(I)之化合物及包含其之組合物可用於處理轉殖基因種子，尤其能夠表現針對害蟲、除草損害或非生物性逆境起作用之多肽或蛋白質的植物之種子，由此增加保護作用。能夠表現針對害蟲、除草損害或非生物性逆境起作用之多肽或蛋白質的植物之種子可含有至少一種允許表現該多肽或蛋白質之異源基因。轉殖基因種子中的此等異源基因可來源於例如以下屬之微生物：芽孢桿菌屬(Bacillus)、根瘤菌屬(Rhizobium)、假單胞菌屬(Pseudomonas)、沙雷菌屬(Serratia)、木黴菌屬(Trichoderma)、棍狀桿菌屬(Clavibacter)、叢枝菌根菌屬(Glomus)或膠黴屬(Gliocladium)。此等異源基因較佳地來源於芽孢桿菌屬，在此情況下基因產物有效抵抗歐洲玉米螟及/或西方玉米根蟲。尤佳地，異源基因來源於蘇力菌。
施加 式(I)化合物可原樣或例如以以下形式施加：備用溶液、乳液、水基或油基懸浮液、粉末、可濕潤粉末、糊、可溶粉末、粉塵、可溶顆粒、用於散佈之顆粒、懸乳劑濃縮物、浸漬有式(I)化合物之天然產物、浸漬有式(I)化合物之合成物質、肥料或聚合物質中之微膠囊劑。
以習用方式、例如藉由澆水、噴灑、霧化、散佈、撒粉、發泡、塗抹及類似者實現施加。亦可藉由超低量方法經由滴灌系統或浸液施加來部署式(I)化合物，以沿溝施加或將其噴射至田埂或土埂中。另外可藉助於傷口密封、塗層或其他傷口敷裹來施加式(I)之化合物。
施加至植物、植物部分、果實、種子或土壤之式(I)化合物的有效及植物相容量將視各種因素而定，該等因素諸如所用化合物/組合物、處理之對象(植物、植物部分、果實、種子或土壤)、處理類型(撒粉、噴灑、拌種)、處理之用途(治癒性及保護性)、微生物類型、微生物之發展階段、微生物之敏感性、作物生長階段及環境條件。
當式(I)之化合物用作殺真菌劑時，施加量可在相對廣範圍內變化，該範圍視施加種類而定。對於處理植物部分(諸如葉片)，施加量的範圍可為0.1至10 000 g/ha，較佳地10至1000 g/ha，更佳地50至300 g/ha (在藉由澆水或滴注施加之情況下，甚至可降低施加量，尤其在使用諸如石棉或珍珠岩之惰性基質時)。對於處理種子，施加量的範圍可為0.1至200 g/100 kg種子、較佳地1至150 g/100 kg種子、更佳地2.5至25 g/100 kg種子、甚至更佳地2.5至12.5 g/100 kg種子。對於處理土壤，施加量可在0.1至10 000 g/ha，較佳1至5000 g/ha範圍內。
此等施加量僅為實例且並不意欲限制本發明之範疇。
可根據以下實例來進一步理解本發明教示之態樣，該等實例不應視為以任何方式限制本發明教示之範疇。
實例 普遍性 LogP 值之量測 LogP值之量測根據EEC指令79/831 Annex V.A8藉由HPLC(高效液相層析)經反相管柱由以下方法執行：[a] LogP值藉由在酸性範圍中用含0.1%甲酸之水及乙腈作為溶離劑(10%乙腈至95%乙腈之線性梯度)進行LC-UV之量測來測定的。[b] LogP值藉由在中性範圍中用含0.001莫耳乙酸銨溶液之水及乙腈作為溶離劑(10%乙腈至95%乙腈之線性梯度)進行LC-UV之量測來確定。[c] LogP值藉由在酸性範圍中用含0.1%磷酸及乙腈作為溶離劑(10%乙腈至95%乙腈之線性梯度)進行LC-UV之量測來測定。
若多於一個LogP值在相同方法中可用，則所有值給出且由「+」分隔開。
用直鏈烷-2-酮(具有3至16個碳原子)在已知LogP值(使用滯留時間及連續烷酮之間的線性內插值量測LogP值)下進行校準。使用200 nm至400 nm之UV光譜及層析信號之峰值測定λ最大值。
1H - NMR 資料
如本文所提供之所選實例之1H-NMR資料以1H-NMR峰清單之形式書寫。對於各信號峰，所列δ值以ppm表示且信號強度在圓括號中表示。δ值信號強度對之間係作為分隔符之分號。
實例之峰清單具有以下形式： δ1 (強度1 )、δ2 (強度2 )、……; δi (強度i )、……; δn (強度n )
在NMR譜之印刷實例中，尖銳信號之強度與信號之高度(cm)相關且展示信號強度之實際關係。自寬信號可展示信號之若干峰值或中間值及其相較於頻譜中之最密集信號之相對強度。
為針對1H光譜校準化學位移，吾人使用四甲基矽烷及/或所用溶劑之化學位移，在DMSO中量測之光譜之情況下尤其如此。因此，在NMR峰清單中，四甲基矽烷峰可能但不一定出現。
1H-NMR峰清單類似於經典1H-NMR印刷圖且因此通常含有經典NMR說明中所列之所有峰。
另外，其可如經典1H-NMR印刷一樣顯示溶劑信號、目標化合物之立體異構體(其亦為本發明之目的)及/或雜質之峰。
為在溶劑及/或水之δ範圍(delta-range)中顯示化合物信號，常用溶劑之峰(例如DMSO於DMSO-D6 中之峰)及水之峰顯示於吾人之1H-NMR峰清單中且具有通常平均之高強度。
目標化合物之立體異構體之峰及/或雜質之峰通常平均具有比目標化合物(例如具有大於90%之純度)之峰低的強度。
此類立體異構體及/或雜質對於特定製備方法可為典型的。因此其峰可經由「副產物指紋」幫助辨認吾人之製備方法之再現。
用已知方法(MestreC、ACD模擬，以及用憑經驗評估之期望值)計算目標化合物之峰的專家可視情況使用另外的強度過濾器按需要分離目標化合物之峰。此分離將類似於經典1H-NMR解釋處之相關峰挑選。
具有峰清單之NMR資料描述的其他詳情見於研究揭示資料庫編號564025之公開案「Citation of NMR Peaklist Data within Patent Applications」中。
以下實例以非限制性方式說明根據本發明之式(I)之化合物之製備及生物活性。
合成式 ( I ) 之化合物及中間物 製備實例 1 ： 製備N-[6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-羰基]-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]胺基甲酸甲酯(化合物I.335) 向6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(100 mg，0.206 mmol)及第三丁醇鉀(34 mg，0.309 mmol)於THF(3 mL)中之溶液中添加氯甲酸甲酯(0.024 mL，0.309 mmol)。在室溫下攪拌反應混合物3小時，隨後用水稀釋且用乙酸乙酯(2×50 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到69 mg(88%純度，54%產率之甲基N-[6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-羰基]-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]呈油狀之胺基甲酸酯。
製備實例 2 ： 製備N-[2-(2,4-二甲基苯基)乙基]-6-甲基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-硫代碳醯胺(化合物I.094) 在微波小瓶中，將N-[2-(2,4-二甲基苯基)乙基]-6-甲基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(97.7 mg，0.22 mmol)及P2 S5 (25.28 mg，0.11 mmol)溶解於二噁烷(4.8 mL)中。密封試管且在微波中在130℃下加熱反應混合物10 min。用水稀釋反應混合物且用乙酸乙酯(2×50 mL)萃取。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到27.5 mg(純度100%，產率27%)呈黃色固體狀之N-[2-(2,4-二甲基苯基)乙基]-6-甲基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-硫代碳醯胺。
製備實例 3 ： 製備6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.014)步驟 1 ： 製備6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸乙酯 在氬氣下，將氫化鈉(2.8 g，70 mmol)添加至3-(三氟甲基)苯酚(9.7 g，60 mmol)於DMF(30 mL)中之溶液中。在室溫下攪拌反應混合物1小時，隨後將3,6-二氯嗒𠯤-4-羧酸乙酯(13.8 g，50 mmol)逐份添加至溶液中。在室溫下攪拌反應混合物18小時，隨後用水稀釋且用二乙醚(3×200 mL)萃取。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到20 g(純度90%，100%產率)呈油狀之乙基6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸乙酯。步驟 2 ：製備6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸 向6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸乙酯(15 g，35 mmol)於二噁烷/水2:1(75 mL)中之溶液中添加氫氧化鋰(2.5 g，105 mmol)。將反應物在室溫下攪拌4小時，隨後用水稀釋。用1M HCl水溶液酸化水相且用乙酸乙酯(3×200 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。蒸發溶劑得到9.7 g(純度98%，產率85%)呈固體狀之6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸。步驟 3 ： 製備6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺 在微波小瓶中，將6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(1.74 g，9.4 mmol)、三乙胺(2 mL，14 mmol)、丙基膦酸酐(5.19 g，8.1 mmol，50%於THF中)及2-(2,4-二甲基苯基)-2,2-二氟乙胺(1.74 g，9.41 mmol)溶解於THF(10 mL)中。密封試管且在微波中在130℃下加熱反應混合物15 min。用水稀釋反應混合物且用乙酸乙酯(2×50 mL)萃取。有機萃取物用碳酸氫鈉飽和水溶液及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。蒸發溶劑得到3.2 g(93%純度，98%產率)呈白色固體狀之6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 4 ： 製備N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-6-氯-3-(2,3-二氟苯氧基)嗒𠯤-4-甲醯胺(化合物I.530)步驟 1 ：製備N-[2-(4-溴-2-氯苯基)-2,2-二氟-乙基]-3,6-二氯-嗒𠯤-4-甲醯胺(化合物3.10) 向3,6-二氯嗒𠯤-4-甲酸(8.0 g，41.4 mmol)於二氯甲烷(50 mL)中之白色懸浮液中依序添加乙二醯氯(7.89 g，126.93 mmol)及兩滴DMF。將反應混合物在室溫下攪拌1小時。向預先形成之醯基氯化物中添加2-(4-溴-2-氯-苯基)-2,2-二氟-乙胺(11.77 g，43.52 mmol)及三乙胺(11.55 mL，82.90 mmol)於DCM(100 mL)中之溶液。在室溫下攪拌反應混合物1小時，隨後其用水稀釋且用DCM(2×100 mL)萃取。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到4.15 g(純度82%，20%產率)呈白色固體狀之N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-3,6-二氯-嗒𠯤-4-甲醯胺。步驟 2 ： 製備N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-6-氯-3-(2,3-二氟苯氧基)嗒𠯤-4-甲醯胺 向N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-3,6-二氯-嗒𠯤-4-甲醯胺(150 mg，0.33 mmol)於AcCN(4 mL)中之溶液中添加2,3-二氟苯酚(56.95 mg，0.44 mmol)及碳酸鉀(93 mg，0.67 mmol)。在室溫下攪拌反應混合物18小時，隨後將其用水稀釋且用乙酸乙酯(2×100 mL)萃取。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由製備型HPLC純化殘餘物，在蒸發溶劑之後得到85 mg(100%純度，46%產率)呈無色油狀之N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-6-氯-3-(2,3-二氟苯氧基)嗒𠯤-4-甲醯胺。
製備實例 5 ：製備6-氯-N-[2-(4-環丙基-2-甲基-苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.240) 在氬氣下，將環丙基硼酸(19.7 mg，0.22 mmol)添加至N-[2-(4-溴-2-甲基-苯基)-2,2-二氟-乙基]-6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(100 mg，0.18 mmol)、乙酸鈀(8.5 mg，0.018 mmol)及磷酸鉀(238.42 mg，1.09 mmol)於甲苯/水(20:1，3 mL)中之經攪拌溶液中之溶液中。在100℃下攪拌反應混合物18小時，經Celite® 過濾，用乙酸乙酯洗滌且在減壓下濃縮。藉由製備型HPLC純化殘餘物，在蒸發溶劑之後得到22 mg(90%純度，21%產率)呈無色油狀之6-氯-N-[2-(4-環丙基-2-甲基-苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 6 ： 製備3-(3-環丁基苯氧基)-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-甲基-嗒𠯤-4-甲醯胺(化合物I.564) 在氬氣下，將NiCl2 .乙二醇二甲醚(0.23 mg ，0.001 mmol)及4,4'-二-第三丁基-2,2'-聯吡啶(0.28 mg，0.001 mmol)於二噁烷(0.5 mL)中之溶液添加至3-(3-溴苯氧基)-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-甲基-嗒𠯤-4-甲醯胺] (100 mg，0.21 mmol )、溴環丁烷(57mg，0.42 mmol)、三(三甲基矽烷基)矽烷(52mg，0.21 mmol)、碳酸鈉(44mg，0.42 mmol)及[Ir(dF(CF3 )ppy)2 (dtbbpy)]PF6 (2.3 mg，0.002 mmol，CAS編號870987-63-6)溶解於中二噁烷(1 mL)中之混合物中。在室溫下在藍光照射下將反應混合物攪拌18小時(Kessyl燈40W)，隨後經Celite® 過濾且在減壓下濃縮。藉由製備型HPLC純化殘餘物，在蒸發溶劑之後得到14 mg(純度85%，產率12%)呈無色油狀之3-(3-環丁基苯氧基)-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-甲基-嗒𠯤-4-甲醯胺。
製備實例 7 ：製備6-乙醯基-N-[rac-2-(4-溴-2-氯-苯基)-2-氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.605)步驟 1 ： 製備6-(1-乙氧基乙烯基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯 在微波小瓶中，在氬氣下將6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯(2.7 g，7.5 mmol)、三丁基(1-乙氧基乙烯基)錫烷(3.38 g，9.35 mmol)及雙(三苯基膦)二氯化鈀(527 mg，0.75 mmol)溶解於DMF(10 mL)中。密封試管且在微波中在120℃下加熱反應混合物20 min。用水稀釋反應混合物且用乙酸乙酯(2×50 mL)萃取。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到2.2 g(95%純度，70%產率)呈固體狀之6-(1-乙氧基乙烯基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯。步驟 2 ：製備6-乙醯基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯(化合物1.075) 在室溫下向6-(1-乙氧基乙烯基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯(1.9 g，4.9 mmol)於THF(20 mL)中之溶液中添加2 M HCl水溶液(7 mL，14 mmol)。攪拌反應物30分鐘，隨後將其用水稀釋且用乙酸乙酯(2×50 mL)萃取。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到1.67 g(純度100%，產率93%)呈油狀之6-乙醯基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯。步驟 3 ： 製備6-乙醯基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(化合物1.034) 向在0℃下冷卻的6-乙醯基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯(600 mg，1.63 mmol)於THF/水9:1(5.5 mL)中之溶液中添加氫氧化鋰(80 mg，3.2 mmol)。將反應物在室溫下攪拌1小時，隨後將其用水稀釋。用1M HCl水溶液酸化水相且用乙酸乙酯(2×50 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。蒸發溶劑得到540 mg(純度90%，產率91%)呈固體狀之6-乙醯基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸。步驟 4 ： 製備6-乙醯基-N-[rac-2-(4-溴-2-氯-苯基)-2-氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺 在微波小瓶中，將6-乙醯基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(350 mg，1.1 mmol)、三乙胺(0.6 mL，4 mmol)、丙基膦酸酐(2.05 g，3.22 mmol，50%於THF中)及rac-2-(4-溴-2-氯-苯基)-2-氟-乙胺氫氯化物(465 mg，1.61 mmol)溶解於THF(7 mL)中。密封試管且在微波中在130℃下加熱反應混合物15 min。用水稀釋反應混合物且用乙酸乙酯(2×50 mL)萃取。有機萃取物用碳酸氫鈉飽和水溶液及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到336 mg(純度92%，51%產率)呈固體狀之6-乙醯基-N-[2-(4-溴-2-氯-苯基)-2-氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 8 ： 製備N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.461)步驟 1 ： 製備6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯(化合物1.066) 在氬氣下，在室溫下將碘化鈉(10.4 g，69.3 mmol)添加至6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯(10.0 g，27.7 mmol)於氫碘酸(30 mL，57%於水中)中之溶液中。添加AcCN(20 mL)且在40℃下攪拌混合物4小時。藉由添加1 M NaOH水溶液停止反應，將pH調節至3-4且用乙酸乙酯(3×200 mL)萃取反應混合物。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到4.3 g(純度86%，產率30%)呈固體狀之6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯。步驟 2 ： 製備6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸 向在0℃下冷卻的6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸異丙酯(800 mg，1.77 mmol)於THF/水9:1(44 mL)中之溶液中添加氫氧化鋰(51 mg，2.12 mmol)。在0℃下攪拌反應物30分鐘，隨後將其用水稀釋。用1M HCl水溶液酸化水相且用乙酸乙酯(2×100 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。蒸發溶劑得到657 mg(100%純度，90%產率)呈固體狀之6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸。步驟 3 ： 製備N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺 在微波小瓶中，將6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(657 mg，1.6 mmol)、三乙胺(0.9 mL，6.4 mmol)、丙基膦酸酐(3.05 g，4.81 mmol，50%於THF中)及2-(2,4-二甲基苯基)-2,2-二氟-乙胺溶解於THF(8 mL)中。密封試管且在微波中在130℃下加熱反應混合物15 min。用水稀釋反應混合物且用乙酸乙酯(2×100 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到621 mg(純度97%，60%產率)呈固體狀之N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 9 ： 製備N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.070)步驟 1 ： 製備6-氯-5-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸甲酯(化合物1.052) 在氬氣下，將TMPZnCl.LiCl之溶液(1.22 mL，0.66 mL，17%於THF中，CAS編號109-99-9)添加至6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸甲酯(200 mg，0.6 mmol)於THF(1.2 mL)中之溶液中。在室溫下攪拌1小時之後，添加NIS(203 mg，0.90 mmol)。反應混合物在室溫下攪拌3小時，隨後將其用飽和硫代硫酸鈉溶液稀釋且用乙酸乙酯(2×50 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到191 mg(純度97%，產率67%)呈黃色固體狀之6-氯-5-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸甲酯。步驟 2 ： 製備6-氯-3-[3-(三氟甲基)苯氧基]-5-乙烯基-嗒𠯤-4-甲酸甲酯(化合物1.069) 在氬氣下，在微波小瓶中，將6-氯-5-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸酯(500 mg，1.1 mmol)、乙烯基三氟硼酸鉀(146 mg，1.1 mmol)、磷酸鉀(463 mg，2.18 mmol)及[1,1'-雙(二苯基膦基)二茂鐵]二氯鈀(II) (179 mg，0.22 mmol)溶解於DME/水2:1(10 mL)中。密封試管且在微波中在110℃下加熱反應混合物30分鐘。反應混合物用飽和氯化銨溶液稀釋且用乙酸乙酯(2×50 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到255 mg(純度98%，產率64%)呈固體狀之6-氯-3-[3-(三氟甲基)苯氧基]-5-乙烯基-嗒𠯤-4-甲酸甲酯。步驟 3 ： 製備6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸甲酯 將甲醇鈉(93 mg，1.71 mmol)添加至6-氯-3-[3-(三氟甲基)苯氧基]-5-乙烯基-嗒𠯤-4-甲酸甲酯(880 mg，2.46 mmol)於甲醇(15 mL)中之溶液中。在室溫下攪拌反應混合物1小時。用飽和碳酸氫鈉水溶液稀釋反應混合物且用乙酸乙酯(2×100 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到223 mg(純度93%，產率22%)之呈油狀之6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸甲酯。步驟 4 ： 製備6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(化合物1.026) 向6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸甲酯(272 mg，0.67 mmol)於THF/水9:1(4 mL)中之溶液中添加氫氧化鋰(33 mg，1.4 mmol)。將反應物在室溫下攪拌8小時，隨後將其用水稀釋。用1M HCl水溶液酸化水相且用乙酸乙酯(2×50 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。蒸發溶劑得到210 mg(100%純度，80%產率)呈固體狀之6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸。步驟 5 ： 製備N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺 在氬氣下，向6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(50 mg，0.133 mmol)及HATU(100 mg，0.26 mmol)於DMF(2 mL)中之溶液中依序添加2-(4-溴-2-氯-苯基)-2,2-二氟-乙胺氫氯化物(53 mg，0.17 mmol)及N,N二異丙基乙胺(0.12 mL, 0.66 mmol)。在室溫下攪拌反應混合物3 h，隨後將其用水稀釋且用乙酸乙酯(2×50 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由製備型HPLC純化殘餘物，在蒸發溶劑之後得到34 mg(100%純度，40%產率)呈無色油狀之N-[2-(4-溴-2-氯-苯基)-2,2-二氟-乙基]-6-氯-5-(2-甲氧基乙基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 10 ： 製備6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.020) 在氬氣下，將TMPZnCl.LiCl(12.35 mmol，22.7 mL，17%於THF中，CAS編號109-99-9)添加至6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(3.0 g，6.2 mmol)於THF(30 mL)中之溶液中。在室溫下攪拌1小時之後，逐份添加NIS(3.4 g，15.4 mmol)。反應混合物在室溫下攪拌2小時，隨後將其用飽和硫代硫酸鈉溶液及飽和碳酸氫鈉溶液稀釋，且用乙酸乙酯(2×250 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到3.05 g(純度100%，80%產率)呈固體狀之6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 11 ： 製備6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-(氧雜環丁-3-基胺基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.408) 在氬氣下，在室溫下將氧雜環丁-3-胺(14.3 mg，0.20 mmol)及N,N-二異丙基乙胺(0.034 mL，0.20 mmol)添加至6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-碘-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(100 mg，0.16 mmol)於AcCN(3 mL)中之溶液中。在60℃下攪拌反應混合物18 h，隨後將其用水稀釋且用乙酸乙酯(2×50 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到79 mg(90%純度，78%產率)呈固體狀之6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-(氧雜環丁-3-基胺基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 12 ： 製備6-氯-N-[2-(4-氯苯基)-2,2-二氟-乙基]-5-乙基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.254) 在氬氣下，在-20℃下將EtMgBr(2.26 mL，2.03 mmol，0.9 M於THF中)之溶液添加至6-氯-N-[2-(4-氯苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(200.0 mg，0.40 mmol)於THF(5 mL)中之溶液中。在-20℃下攪拌反應混合物30分鐘，隨後添加MeOH(1 mL)及NBS(86.7 mg，0.49 mmol)。在室溫下進一步攪拌反應混合物2小時，隨後將其用飽和氯化銨溶液稀釋且用乙酸乙酯(2×50 mL)萃取。有機萃取物用水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到94 mg(純度100%，產率45%)呈固體狀之6-氯-N-[2-(4-氯苯基)-2,2-二氟-乙基]-5-乙基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 13 ： 製備6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-(3-吡啶基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.550) 在氬氣下，將TMPZnCl.LiCl(0.86 mmol，1.6 mL，17%於THF中)添加至6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(200 mg，0.41 mmol)於THF(2 mL)中之溶液中。在室溫下攪拌1 h之後，添加3-溴吡啶(0.048 mL，0.49 mmol)、乙酸鈀(71 mg，0.123 mmol)及三呋喃膦(57.3 mg，0.24 mmol)。將反應混合物在60℃下攪拌4小時，隨後用飽和氯化銨溶液及飽和硫代硫酸鈉溶液稀釋，且用乙酸乙酯(2×50 mL)萃取。有機萃取物用鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到227 mg(96%純度，94%產率)呈固體狀之6-氯-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-(3-吡啶基)-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 14 ： 製備N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺(化合物I.767)步驟 1 ： 製備6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸乙酯 在氬氣下，將甲硫醇化鈉(85 mg，1.15 mmol)添加至6-氯-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸乙酯(400 mg，1.15 mmol)於DMF(3 mL)中之溶液中。在室溫下攪拌反應混合物2小時，隨後用飽和氯化銨溶液稀釋且用乙酸乙酯(2×100 mL)萃取。有機萃取物用水及鹽水洗滌，經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由製備型HPLC純化殘餘物，在蒸發溶劑之後得到43 mg(100%純度，10%產率)呈油狀之6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸乙酯。步驟 2 ： 製備6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(化合物1.004) 向6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸乙酯(71 mg，0.20 mmol)於THF/水2:1(1.5 mL)中之溶液中添加氫氧化鋰(6 mg，0.24 mmol)。將反應物在室溫下攪拌1小時，隨後將其用水稀釋。用1M HCl水溶液酸化水相且用乙酸乙酯(2×50 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。蒸發溶劑得到34 mg(100%純度，51%產率)呈白色固體狀之6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸。步驟 3 ： 製備N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺 在微波小瓶中，將6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲酸(34 mg，0.10 mmol)、三乙胺(0.06 mL，0.4 mmol)、丙基膦酸酐(195 mg，0.30 mmol，50%於THF中)及2-(2,4-二甲基苯基)-2,2-二氟-乙胺氫氯化物(34 mg；0.15 mmol)溶解於THF(0.4 mL)中。密封試管且在室溫下攪拌反應混合物1小時。用水稀釋反應混合物且用乙酸乙酯(2×50 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。蒸發溶劑之後，21 mg(純度100%，產率41%)呈黃色固體狀之N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-6-甲基硫基-3-[3-(三氟甲基)苯氧基]嗒𠯤-4-甲醯胺。
製備實例 15 ： 製備6-氯-3-(3-氯苯氧基)-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-甲基-嗒𠯤-4-甲醯胺(化合物I.790)步驟 1 ： 製備6-氯-3-(3-氯苯氧基)-5-甲基-嗒𠯤-4-甲酸甲酯(化合物1.033) 在室溫下，向6-氯-3-(3-氯苯氧基)嗒𠯤-4-甲酸甲酯(24 g，80 mmol)於二甲亞碸(75 mL)中之溶液中添加硝基甲烷(24 g，400 mmol)。在30分鐘之後，添加三乙胺(16.7 mL，120 mmol)。在室溫下攪拌反應混合物3天，隨後將其用水稀釋。用乙酸乙酯(500 mL)萃取水相且經硫酸鎂乾燥有機萃取物，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到18.9 g(96%純度，72%產率)呈黃色油狀之6-氯-3-(3-氯苯氧基)-5-甲基-嗒𠯤-4-甲酸甲酯。步驟 2 ： 製備6-氯-3-(3-氯苯氧基)-5-甲基-嗒𠯤-4-甲酸(化合物1.002) 在0℃下向6-氯-3-(3-氯苯氧基)-5-甲基-嗒𠯤-4-甲酸甲酯(8 g，25 mmol)於THF/水2:1(60 mL)中之溶液中添加氫氧化鋰(2.3 g，31 mmol)。將反應物在室溫下攪拌4小時，隨後將其用水稀釋。用二乙醚(2×60 mL)萃取水相，隨後用1M HCl水溶液酸化。將水相冷卻至0℃，濾出白色沈澱，減壓乾燥，得到7.2 g(純度97%，產率91%)呈白色固體狀之6-氯-3-(3-氯苯氧基)-5-甲基-嗒𠯤-4-甲酸。步驟 3 ： 製備6-氯-3-(3-氯苯氧基)-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-甲基-嗒𠯤-4-甲醯胺 在氬氣下，在0℃下向冷卻的6-氯-3-(3-氯苯氧基)-5-甲基-嗒𠯤-4-甲酸(200 mg，0.67 mmol)及HATU(0.33 g，0.87 mmol)於DMF(3 mL)中之溶液中連續添加2-(2,4-二甲基苯基)2,2-二氟-乙胺氫氯化物(185 mg，0.84 mmol)及N,N-二異丙基乙胺(0.35 mL，2.0 mmol)。將反應混合物在室溫下攪拌18小時，隨後將其用水稀釋且用乙酸乙酯(2×200 mL)萃取。有機萃取物經硫酸鎂乾燥，過濾且在減壓下濃縮。藉由矽膠管柱層析(梯度庚烷/EtOAc)純化殘餘物，在蒸發溶劑之後得到200 mg(純度97%，產率62%)呈白色固體狀之6-氯-3-(3-氯苯氧基)-N-[2-(2,4-二甲基苯基)-2,2-二氟-乙基]-5-甲基-嗒𠯤-4-甲醯胺。
與上文所提供之實例類似地製備如下表1中所示之化合物。此等化合物之1 H-NMR資料展示於表2中。
表1：根據式(I)之化合物
Figure 02_image077
Ex N° R1 R7 R8 T Q
Figure 02_image079
 LogP
I-001 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)乙基 4.46[a]
I-002 H H H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.90[a]
I-003 H Cl 甲基 O 3-(三氟甲基)苯基 2-(2-甲基-1,3-苯并噁唑-4-基)乙基 3.39[a]
I-004 H 3-氟吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.41[a] ;4.41[b]
I-005 H Cl 甲基 O 3-(三氟甲基)苯基 rac-1-(3,4-二甲基苯基)乙基 4.15[a]
I-006 H Cl H O 萘-2-基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.78[a]
I-007 H Cl H O 3-(三氟甲基)苯基 2-(2-氯-4-甲氧基苯基)-2,2-二氟乙基 4.00[a]
I-008 H Cl H O 3-(三氟甲基)苯基 異喹啉-7-基甲基 1.87[a]
I-009 H 甲基 1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.91[a] ;3.81[b]
I-010 H Cl I O 3-(二氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.94[a]
I-011 H 3-甲氧基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.94[a] ;4.21[b]
I-012 H 甲基 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.11[a]
I-013 H 甲基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)丙-2-基 4.01[a]
I-014 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.46[a]
I-015 H Cl 環丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.25[a]
(*) I-016 H 環丙基 H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2-氟乙基 4.69[a]
I-017 H 甲基 H O 3-(三氟甲基)苯基 2-(4-甲氧基苯基)丙-2-基 3.51[a]
I-018 H 甲基 H O 3-(三氟甲基)苯基 2-(2-氯-4-環己基苯基)-2,2-二氟乙基 5.44[a]
I-019 H Cl H O 3-(三氟甲基)苯基 2-(3,5-二甲基苯基)-2,2-二氟乙基 4.46[a]
I-020 H Cl I O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.61[a]
I-021 H CF3 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.90[a]
I-022 H 3-甲基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.49[a] ;4.27[b]
I-023 H Cl H O 3-(三氟甲基)苯基 rac-1-萘-2-基乙基 4.28[a]
(*) I-024 H 環丙基 H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2-氟乙基 4.69[a]
I-025 H H 環丙基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.39[a] ;4.20[b]
I-026 H 甲基 H O 3-(三氟甲基)苯基 2-(4-氟苯基)丙-2-基 3.62[a]
I-027 H 甲基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)乙基 3.73[a]
I-028 H 甲基 H O 3-(三氟甲基)苯基 2-(2-氯-4-環丁基苯基)-2,2-二氟乙基 4.83[a]
I-029 H Cl 甲基 O 3-環丙基苯基 2-(2,4-二氯苯基)乙基 4.51[a]
I-030 H Cl H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.27[a]
I-031 H 甲基 H O 3-(三氟甲基)苯基 [5-氯-7-(三氟甲基)咪唑[1,2-a]吡啶-2-基]甲基 3.17[a]
I-032 H Cl H O 5-(三氟甲基)吡啶-3-基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.73[a] ;3.89[b]
I-033 H Cl I O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.46[a]
I-034 H 甲基 H O 3-(三氟甲基)苯基 2-[3-(三氟甲基)苯基]丙-2-基 3.96[a]
I-035 H 甲基 H O 3-(三氟甲基)苯基 2-(2-氯-4-環戊基苯基)-2,2-二氟乙基 5.08[a]
I-036 H Cl H O 3-(三氟甲基)苯基 2-(4-甲氧基苯基)乙基 3.61[a]
I-037 H Cl H O 3-(三氟甲基)苯基 2-[3-(三氟甲基)吡啶-2-基]乙基 3.65[a]
I-038 H CF3 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.49[a]
I-039 H 甲基 CF3 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.29[a]
I-040 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.80[a]
I-041 H 甲基 乙基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.87[a]
I-042 H Cl H O 5-(三氟甲基)吡啶-3-基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.06[a] ;4.08[b]
I-043 H H 環丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.73[a] ;4.88[b]
I-044 H 甲基 H O 3-(三氟甲基)苯基 2-(4-甲基苯基)丙-2-基 3.96[a]
I-045 H 甲基 乙基 O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.15[a]
I-046 H 甲基 H O 3-(三氟甲基)苯基 2-[2-氯-4-[rac-氧戊環-3-基]苯基]-2,2-二氟乙基 3.48[a]
I-047 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.61[a]
I-048 H 甲基 H O 3-(三氟甲基)苯基 rac-6-溴-1,2,3,4-四氫萘-1-基 4.32[a] ;4.25[b]
I-049 H 甲基 H O 3-(三氟甲基)苯基 (2,4-二甲基苯基)甲氧基 3.55[a]
I-050 H 甲基 甲基 O 3-(三氟甲基)苯基 rac-2-(4-氯苯基)-2-氟乙基 3.46[a]
I-051 H Cl H O 6-(三氟甲基)吡啶-2-基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.51[b]
I-052 H 吡咯啶-1-基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.81[a]
I-053 H 甲基 乙基 O 3-(三氟甲基)苯基 rac-2-(2-氯-4-甲基苯基)-2-氟乙基 3.99[a]
I-054 H Cl H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.72[a]
I-055 H Cl H O 3-羥基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.29[a]
I-056 H Cl 乙烯基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.46[a]
I-057 H CF3 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.90[a]
I-058 H H H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.85[a]
I-059 H Cl H O 3-(三氟甲基)苯基 2-(2,6-二氯吡啶-3-基)-2,2-二氟乙基 3.85[a]
I-060 H H H O 3-(三氟甲基)苯基 2-(2,4-二甲氧基苯基)乙基 3.21[a]
I-061 H Cl H O 3-(三氟甲基)苯基 2-[3-(三氟甲基)苯基]丙-2-基 4.41[a]
I-062 H Cl 甲基 O 3-環丙基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.46[a]
I-063 H Cl 甲基 O 3-環丙基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.44[a]
I-064 H Cl (2-甲基-2-三甲基矽烷基氧基丙基)胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 6.32[a]
I-065 H Cl H O 3-[rac-2,2-二氟環丙基]苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.39[a]
I-066 H 甲氧基 H O 3-(三氟甲基)苯基 1-(4-氯苯基)乙基 4.03[a]
I-067 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二氟苯基)-2,2-二氟乙基 3.75[a]
I-068 H Cl H O 3-(三氟甲基)苯基 2-[5-(三氟甲基)吡啶-2-基]乙基 3.53[a]
I-069 H H H O 3-(三氟甲基)苯基 rac-2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 3.96[a]
I-070 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.77[a]
I-071 H H H O 3-(三氟甲基)苯基 2-(5-氯吡啶-2-基)-2,2-二氟乙基 3.13[a]
I-072 H Cl 甲基亞磺醯基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.75[a]
I-073 H Cl H O 3-(三氟甲基)苯基 2-(3,5-二氯吡啶-2-基)-2,2-二氟乙基 4.05[a]
I-074 H 甲基 甲基 O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.90[a]
I-075 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)丙基 4.68[a]
I-076 H Cl 吡啶-4-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.92[a]
I-077 H Cl [乙醯基(甲基)胺基]甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 3.65[a]
I-078 H Cl 甲基磺醯基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.03[a]
I-079 H Cl H O 3-(三氟甲基)苯基 [1-(2,4-二氯苯基)環丙基]甲基 4.85[a]
I-080 H Cl H O 3-甲基硫基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.41[a]
I-081 H Cl 乙烯基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.56[a]
I-082 H CF3 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.74[a]
I-083 H Cl I O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.34[a]
I-084 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(1-甲基-1H-吲哚-3-基)乙基 3.55[a]
I-085 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.44[a]
I-086 H Cl H O 3-[rac-2,2-二氟環丙基]苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.44[a]
I-087 H Cl H O 3-(三氟甲基)苯基 2-[2-氯-4-(2,2,2-三氟乙基硫基)苯基]-2,2-二氟乙基 4.45[a]
I-088 H CN H O 3-(三氟甲基)苯基 1-[3-(三氟甲基)苯基]乙基 4.08[a]
I-089 H 環丙基胺基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.69[a]
I-090 H I H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.85[a]
(*) I-091 H 甲基 H O 3-(三氟甲基)苯基 1-[4-(三氟甲基)苯基]乙基 3.83[a]
I-092 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.53[a]
I-093 H Cl 2-氧代-6-氮螺[3.3] 庚烷-6-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.89[a]
I-094 H 甲基 H S 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.69[a]
I-095 H 甲基 H O 3-(三氟甲基)苯基 [4-(三氟甲基)苯基]甲氧基 3.44[a]
I-096 H Cl 1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.34[a]
I-097 H Cl H O 3-(三氟甲基)苯基 rac-5-溴二氫茚-2-基 4.37[a] ;4.31[b]
(*) I-098 H 甲基 H O 3-(三氟甲基)苯基 1-[4-(三氟甲基)苯基]乙基 3.83[a]
I-099 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-(5-甲基吡啶-2-基)乙基 3.46[a]
I-100 H Cl OH O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.01[a]
I-101 H 甲基 H O 3-(二氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.41[a]
I-102 H 甲基 H O 3-(三氟甲基)苯基 rac-7-氯-6-氟-2,2-二甲基𠳭烷-4-基 4.41[a]
I-103 H Cl H O 3-聯環[4.2.0]辛-1(6),2,4-三烯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.56[a]
I-104 H Cl 環丙基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.37[a]
I-105 H 二甲基胺基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.21[a]
I-106 H Cl 1,3-噻唑-4-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.25[a]
I-107 H 甲基 H O 3-(三氟甲基)苯基 rac-8-甲基𠳭烷-4-基 3.65[a]
I-108 H Cl H O 3-(三氟甲基)苯基 2-(5-氯吡啶-2-基)-2,2-二氟乙基 3.65[a]
I-109 H Cl H O 3-(三氟甲基)苯基 rac-2-(2,4-二甲基苯基)環丙基 4.56[a]
I-110 H Cl 1H-咪唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.62[a]
I-111 H 二甲基胺基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.82[a]
I-112 H 甲基 H O 3-(三氟甲基)苯基 2-[2-氯-4-(氧烷-4-基)苯基]-2,2-二氟乙基 3.71[a]
I-113 H Cl H O 3-(三氟甲基)苯基 2-(5-溴-3-氯吡啶-2-基)-2,2-二氟乙基 4.17[a]
I-114 H Cl 環丙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.69[a]
I-115 H Cl 氧雜環丁-3-基氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.21[a]
I-116 H 甲基 H O 3-(三氟甲基)苯基 rac-3-(4-氯苯基)-1-甲氧基-1-氧丙-2-基 3.73[a]
I-117 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(5,6,7,8-四氫萘-2-基)乙基 4.41[a]
I-118 H 甲基 H O 3-(三氟甲基)苯基 rac-6-氟硫基𠳭烷-4-基 3.59[a]
I-119 H Cl 甲氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.32[a]
I-120 H Cl 環丙基 O 3-(三氟甲基)苯基 rac-1-(4-甲基苯基)乙基 4.25[a]
I-121 H Cl H O 6-(三氟甲基)吡啶-2-基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.03[a] ;4.18[b]
I-122 H 環丙基 H O 3-(二氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.32[a]
I-123 H 甲基 H O 3-(三氟甲基)苯基 2-(4-氰基苯基)丙-2-基 3.21[a]
I-124 H 甲基 甲基 O 2-氟-3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.01[a]
I-125 H Cl H O 4-氟-3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.54[a]
I-126 H Cl 環丙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.51[a]
I-127 H Cl H O 6-(三氟甲基)吡啶-2-基 2-(4-氯苯基)-2,2-二氟乙基 3.69[a] ;3.70[b]
I-128 H 甲基 H O 5-(三氟甲基)吡啶-3-基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.48[a] ;3.55[b]
I-129 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(3-氟-4-甲氧基苯基)乙基 3.21[a]
I-130 H Cl 4-甲基-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.54[a]
I-131 H Cl 乙烯基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.32[a]
I-132 H Cl H O 3-(三氟甲基)苯基 rac-2-(3-氯苯基)環丙基 4.03[a]
I-133 H CN 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.33[a] ;4.44[b]
I-134 H 甲基 甲基 O 2-氟-3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.92[a]
I-135 H 氧雜環丁-3-基 H O 3-氯苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.69[a]
I-136 H Cl 2-甲氧基-2-甲基丙氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.82[a]
I-137 H Cl 3-(二氟甲基)-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.61[a]
I-138 H Cl H O 3-甲基苯基 1-(3-甲基苯基)乙基 3.76[a]
I-139 H Cl 乙烯基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)乙基 4.72[a]
I-140 H Cl Cl O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.67[a]
I-141 H Cl H O 6-(三氟甲基)吡啶-2-基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.06[a] ;4.20[b]
(*) I-142 H Cl H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2-氟乙基 4.56[a] ;4.49[b]
I-143 H 甲基 H O 3-(三氟甲基)苯基 rac-6-甲氧基-1,2,3,4-四氫萘-1-基 3.64[a]
I-144 H Cl 乙基 O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.81[a]
I-145 H 甲基 甲基 O 2-氟-3-(三氟甲基)苯基 2-(2,4-二氯苯基)乙基 3.94[a]
I-146 H Cl 氧雜環丁-3-基 O 3-氯苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.96[a]
(*) I-147 H Cl H O 3-(三氟甲基)苯基 2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 4.71[a]
I-148 H 環丙基 環丙基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.87[a]
I-149 H CN 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.42[a] ;4.48[b]
I-150 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(3-溴苯基)乙基 3.73[a]
I-151 H 乙基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.46[a]
I-152 H 甲基 H O 3-(三氟甲基)苯基 rac-2-(2-氯-4-丙-1-烯-2-基苯基)-2-氟乙基 4.41[a] ;4.35[b]
I-153 H Cl 甲氧基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.49[a]
I-154 H Cl 乙烯基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.77[a]
I-155 H Cl Cl O 3-(三氟甲基)苯基 2,2-二氟-2-(3-甲基苯基)乙基 4.34[a]
I-156 H Cl H O 3-(三氟甲基)苯基 rac-2-(2-氯苯基)環丙基 4.13[a]
I-157 H 吡啶-4-基 環丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.37[a]
I-158 H Cl H O 3-(二氟甲基)苯基 2-(5-氯吡啶-2-基)-2,2-二氟乙基 3.32[a]
I-159 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(6-甲氧基萘-2-基)乙基 3.83[a]
I-160 H 乙基 H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.49[a]
I-161 H Cl 3-[rac-氧戊環-2-基]-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.51[a]
I-162 H Cl 甲氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.44[a]
I-163 H Cl 乙氧基 O 3-(三氟甲基)苯基 2,2-二氟-2-(3-氟苯基)乙基 4.11[a]
I-164 H 乙醯基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.54[a]
I-165 H Cl H O 3-溴-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.46[a]
I-166 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(3,4-二氟苯基)乙基 3.39[a]
I-167 H 甲基 H O 3-(三氟甲基)苯基 rac-6-甲基-3,4-二氫-1H-異𠳭烯-4-基 3.31[a]
I-168 H Cl 甲氧基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.18[a]
I-169 H Cl 乙烯基 O 3-(三氟甲基)苯基 rac-1-(4-甲基苯基)乙基 4.15[a]
I-170 H Cl H O 3-(三氟甲基)苯基 2-(4-氰基-2-甲基苯基)乙基 3.37[a]
I-171 H 甲基 H S 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.69[a]
I-172 H 甲基 H O 3-(二氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.85[a]
I-173 H Cl H O 5-溴吡啶-3-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.78[a]
I-174 H Cl 乙氧基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.41[a]
I-175 H Cl H O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.80[a]
I-176 H 甲基 H O 3-(二氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.68[a]
I-177 H Cl 乙氧基 O 3-(三氟甲基)苯基 2,2-二氟-2-(3-甲基苯基)乙基 4.34[a]
I-178 H Cl H O 3-(氧雜環丁-3-基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.83[a]
I-179 H 甲基 H O 3-溴苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.16[a]
I-180 H 環丙基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.51[a] ;4.47[b]
I-181 H Cl 乙氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.68[a]
I-182 H Cl H O 3-(二氟甲基)苯基 2-(4-溴苯基)-2,2-二氟乙基 3.92[a]
I-183 H H 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.78[a]
I-184 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(1,3-苯并間二氧雜環戊烯-5-基)乙基 3.13[a]
I-185 H Cl H O 3-(氧雜環丁-3-基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.64[a]
I-186 H Cl [rac-1-甲氧基丙-2-基]氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.76[a]
I-187 H Cl H O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.72[a]
I-188 H Cl 甲基 O 3-(三氟甲基)苯基 2-(7-甲氧基-2-甲基-1-苯并呋喃-4-基)乙基 3.90[a]
I-189 H Cl 氧雜環丁-3-基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.90[a]
I-190 H 甲基 H O 3-溴苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.01[a]
I-191 H 甲基 H O 2-氟-3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.11[a]
I-192 H Cl 乙氧基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.86[a]
I-193 H 甲基 H O 2-氟-3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.49[a]
I-194 H 甲基 H O 3-(二氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.72[a]
(*) I-195 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(2,3-二氫-1-苯并呋喃-5-基)乙基 3.19[a]
I-196 H 乙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.66[a]
I-197 H Cl (2-甲基-1,3-二氧戊環-4-基)甲基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.41[a]
I-198 H 甲基 H O 3-氯苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.11[a]
I-199 H Cl 乙氧基 O 3-(三氟甲基)苯基 rac-1-(4-甲基苯基)乙基 4.25[a]
I-200 H 甲基 H O 2-氟-3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.19[a]
I-201 H 1-異二氮烯乙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.18[a]
I-202 H Cl 3-羥基氧雜環丁-1-基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.31[a]
I-203 H Cl H O 3-(二氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.23[a]
I-204 H Cl 甲基 O 3-(二氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.79[a]
I-205 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(3,4-二甲基苯基)乙基 3.89[a]
I-206 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(5-氯-2,3-二氫-1-苯并呋喃-7-基)乙基 3.96[a]
I-207 H Cl 氧雜環丁烷-4-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.17[a]
I-208 H Cl H O 3-(三氟甲基)苯基 6-甲基-1,2,3,4-四氫萘-2-基 4.59[a] ;4.48[b]
I-209 H Cl H O 3-氯-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.44[a]
I-210 H 甲基 H O 3-(三氟甲基)苯基 1-[(4-甲基苯基)甲基]環丙基 3.73[a]
I-211 H Cl 甲基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.68[a]
I-212 H Cl H O 3-(二氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.13[a]
I-213 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(3-氯苯基)乙基 3.60[a]
I-214 H 甲基 H O 3-(三氟甲基)苯基 1-(2-甲基-2,3-二氫苯并呋喃-5-基)乙基 3.46[a]
I-215 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)乙基 4.58[a]
I-216 H Cl 4-(乙氧基羰基)-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.69[a]
I-217 H 乙基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.05[a]
I-218 H 甲基 H O 3-氯苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.92[a]
I-219 H Cl H O 3-溴-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.49[a]
I-220 H CN H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.34[a]
I-221 H Cl 乙氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.53[a]
I-222 H 丙-1-烯-2-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.87[a]
I-223 H 甲基 H O 2-氟-3-(三氟甲基)苯基 rac-2-(4-氯苯基)-2-氟乙基 3.71[a]
I-224 H 甲基 H O 3-(三氟甲基)苯基 1-(4-氯苯基)-2-甲基丙-2-基 4.32[a]
I-225 H Cl 2-羥基乙基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.29[a]
I-226 H 甲基 H O 3-(二氟甲基)苯基 2-(4-溴苯基)-2,2-二氟乙基 3.46[a]
I-227 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(3,4-二氯苯基)乙基 3.99[a]
I-228 H 1H-咪唑-1-基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.31[a] ;4.06[b]
(*) I-229 H 甲基 H O 3-(三氟甲基)苯基 1-(2,3-二氫-1-苯并呋喃-5-基)乙基 3.17[a]
I-230 H Cl 5-環丙基-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.82[a]
I-231 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.51[a]
I-232 H Cl H O 3-胺基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.23[a]
(*) I-233 H 甲基 H O 2-氟-3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.24[a]
I-234 H Cl 2-羥基乙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.48[a]
I-235 H 甲基 H O 3-(二氟甲基)苯基 2-(5-氯吡啶-2-基)-2,2-二氟乙基 2.92[a]
I-236 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(6-甲基萘-2-基)乙基 4.23[a]
I-237 H Cl 4-氰基-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.32[a]
I-238 H Cl 甲基硫基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.56[a]
I-239 H Cl H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2-氟乙基 3.99[a] ;3.94[b]
I-240 H Cl H O 3-(三氟甲基)苯基 2-(4-環丙基-2-甲基苯基)-2,2-二氟乙基 4.77[a]
I-241 H Cl 環己基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 5.27[a]
I-242 H 甲基 H O 3-(二氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.63[a]
I-243 H Cl H O 3-(三氟甲基)苯基 2-(2-氰基-4-甲基苯基)乙基 4.33[a]
I-244 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(4-溴苯基)乙基 3.76[a]
(*) I-245 H Cl H O 3-(三氟甲基)苯基 6-甲基-1,2,3,4-四氫萘-1-基 4.61[a] ;4.51[b]
I-246 H 甲基 H O 3-(三氟甲基)苯基 2-(2,5-二氟苯基)乙基 3.35[a]
I-247 H Cl H O 3-環丙基苯基 2-(4-氯苯基)-2,2-二氟乙基 4.41[a]
I-248 H 甲基 H O 2-氟-3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.18[a]
I-249 H Cl 1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.13[a]
I-250 H Cl 3-氯吡啶-4-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.49[a]
I-251 H 環丙基 H O 3-(二氟甲基)苯基 2-(5-氯吡啶-2-基)-2,2-二氟乙基 3.46[a]
I-252 H 1H-咪唑-1-基 H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.23[a] ;3.99[b]
I-253 H Cl H O 3-(三氟甲基)苯基 rac-1-[3-(三氟甲基)苯基]乙基 4.24[a]
I-254 H Cl 乙基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.51[a]
(*) I-255 H 環丙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.80[a]
I-256 H Cl 二甲基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.41[a]
I-257 H Cl (4-甲氧基-4-氧丁基)胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.23[a]
I-258 H 環丙基 H O 3-(二氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.27[a]
I-259 H Cl H O 苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.11[a]
I-260 H Cl H O 2-氟-3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.54[a]
I-261 H Cl H O 3-(三氟甲基)苯基 rac-1-(4-甲基苯基)乙基 4.15[a]
I-262 H Cl 吡咯啶-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.56[a]
I-263 H 環丙基 H O 3-(二氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.87[a]
I-264 H 甲基 H O 3-(二氟甲基)-2-氟苯基 2-(4-氯苯基)-2,2-二氟乙基 3.50[a]
I-265 H Cl 2-甲氧基乙氧基甲基 O 3-氯苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.20[a]
I-266 H 甲基 甲基 O 3-氯苯基 2-(4-甲基苯基)丙-2-基 3.39[a]
(*) I-267 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.59[a]
I-268 H Cl H O 3-(三氟甲基)苯基 2-(3,4-二甲氧基苯基)乙基 3.26[a]
I-269 H Cl 苯基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.85[a]
I-270 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二氟苯基)乙基 3.85[a] ;3.79[b]
I-271 H Cl 1H-咪唑-1-基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.44[a]
I-272 H Cl 環己基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.98[a]
I-273 H Cl H O 3-(二氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.25[a]
I-274 H Cl H O 3-(三氟甲基)苯基 rac-7-溴-1,2,3,4-四氫萘-1-基 4.51[a]
I-275 H 3-氯吡啶-4-基 H O 3-(二氟甲基)-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.11[a]
I-276 H Cl H O 3-(三氟甲基)苯基 rac-2-(4-氯苯基)環丙基 3.89[a]
I-277 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-(3-甲基苯基)乙基 4.23[a]
I-278 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-[4-[4-(甲氧基羰基)苯基]-2-甲基苯基]乙基 4.85[a]
I-279 H 甲基 甲基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.60[a]
I-280 H Cl 苯胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.23[a]
I-281 H 環丙基 H O 3-(二氟甲基)苯基 2-(4-溴苯基)-2,2-二氟乙基 3.99[a]
I-282 H 甲基 H O 3-環丙基苯基 2-[5-(二氟甲基)吡啶-2-基]乙基 2.82[b]
I-283 H 甲基 H O 3-(二氟甲基)-2-氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.94[a]
I-284 H 甲基 甲基 O 3-環丙基-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.01[a]
I-285 H Cl [rac-1-羥基-3-甲氧基丙-2-基]氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.90[a]
I-286 H Cl H O 3-(三氟甲基)苯基 2-(2,5-二氟苯基)乙基 3.82[a]
I-287 H Cl H O 3-氯-5-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.59[a]
(*) I-288 H 環丙基 H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.57[a]
I-289 H Cl 二甲基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.15[a]
I-290 H 環丙基 H O 3-(二氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.15[a]
I-291 H Cl H O 5-(三氟甲基)-3-噻吩基 2-(2,4-二甲基苯基)乙基 4.55[a]
I-292 H CN H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.08[a]
I-293 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.51[a]
I-294 H 甲氧基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.34[a]
I-295 H 環丙基 H O 3-(二氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.18[a]
I-296 H Cl 甲基 O 3-(三氟甲基)苯基 2-(4-甲基苯基)丙-2-基 4.20[a]
I-297 H Cl H O 3-(三氟甲基)苯基 2-(4-溴苯基)-2-氟乙基 4.13[a] ;4.08[b]
I-298 H CN H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.49[a]
I-299 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-[2-甲基-4-(1-甲基-1H-吡唑-4-基)苯基]乙基 3.60[a]
I-300 H Cl H O 2-氟-3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.26[a]
I-301 H Cl 甲基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.90[a]
I-302 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(4-氟苯基)乙基 3.29[a]
I-303 H Cl 乙基 O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.88[a]
I-304 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.72[a]
I-305 H 甲基 H O 3-硝基苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.62[a]
I-306 H Cl H O 3-(三氟甲基)苯基 喹啉-3-基甲基 2.71[a]
I-307 H (1E)-1-(甲氧基亞胺)乙基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.77[a]
I-308 H Cl 3-羥基氧雜環丁烷-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.50[a]
I-309 H Cl H O 3-(三氟甲基)苯基 2-[4-(二氟甲基)苯基]乙基 3.78[a]
I-310 H 甲基 H O 3-(三氟甲基)苯基 rac-1-(3-甲氧基苯基)乙基 3.25[a]
I-311 H 甲基 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)乙基 3.96[a]
I-312 H 環丙基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.79[a] ;4.68[b]
I-313 H 甲基 H O 3-硝基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.46[a]
I-314 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-[2-甲基-4-[2-(三氟甲基)環丙基]苯基]乙基 4.90[a]
I-315 H Cl H O 2-氟-3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.71[a]
I-316 H 吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.65[a]
I-317 H 甲基 甲氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.99[a]
I-318 H Cl H O 3-(三氟甲基)苯基 rac-6-甲氧基-1,2,3,4-四氫萘-1-基 4.13[a]
I-319 H 3-氯吡啶-4-基 H O 3-(二氟甲基)-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.25[a]
I-320 H Cl H O 3-(三氟甲基)苯基 rac-1-[4-(三氟甲基)苯基]乙基 4.23[a]
I-321 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-苯基乙基 3.73[a]
I-322 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.40[a]
I-323 H Cl H O 3-(三氟甲基)苯基 2-(4-氯苯基)丙基 4.28[a]
I-324 H 3-氯吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-325 H Cl H O 3-(三氟甲基)苯基 [rac-6-氯-2,3-二氫-1-苯并呋喃-3-基]甲基 3.99[a] ;3.90[b]
I-326 H H I O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.24[a]
I-327 H Cl H O 3-碘基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.61[a]
I-328 H Cl H O 3-(三氟甲基)苯基 2-(4-氯-2-甲基苯基)-2,2-二氟乙基 4.51[a]
I-329 H Cl H O 3-(三氟甲基)苯基 1-[(4-氯苯基)甲基]環丙基 4.17[a]
I-330 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 rac-1-(4-甲基苯基)乙基 4.23[a]
I-331 H Cl H O 3-(三氟甲基)苯基 rac-5-溴二氫茚-1-基 4.52[a] ;4.42[b]
I-332 H Cl H O 3-(三氟甲基)苯基 rac-1-(1-甲基-1H-吲哚-3-基)乙基 4.03[a]
I-333 H H 環丙基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.18[a]
I-334 H Cl H O 3-(三氟甲基)苯基 2-(4-溴-2-氰基苯基)-2,2-二氟乙基 3.89[a]
I-335 甲氧基羰基 Cl H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 5.19[a]
I-336 H 甲基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.94[a]
I-337 H Cl H O 2-氟-3-甲氧基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.01[a]
I-338 H Cl 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.43[a]
I-339 H Cl 氧雜環丁-3-基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.47[a] ;3.32[b]
I-340 H Cl H O 3-(三氟甲基)苯基 rac-1-(6-甲氧基萘-2-基)乙基 4.27[a]
I-341 H Cl H O 3-(三氟甲基)苯基 2-[4-甲基-2-(1-甲基-1H-咪唑-2-基)苯基]乙基 1.85[a]
I-342 H 甲基 甲基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.90[a]
I-343 H 甲基 H O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)乙基 4.32[a]
I-344 H 甲基 H O 3-(三氟甲基)苯基 2-(4-溴-2-甲基苯基)-2,2-二氟乙基 4.17[a]
I-345 H Cl OH O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.28[a]
I-346 H Cl H O 3-(三氟甲基)苯基 rac-1-(3-溴苯基)乙基 4.23[a]
I-347 H 甲基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 3.99[a]
I-348 H 甲基 H O 3-(三氟甲基)苯基 2-(4-氯-2-甲基苯基)-2,2-二氟乙基 4.05[a]
I-349 H Cl OH O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.51[a]
I-350 H rac-1-羥基乙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯-苯基)-2-氟乙基 3.69[a]
I-351 H 3-氯吡啶-4-基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.39[a] ;4.51[b]
I-352 H Cl H O 3-(三氟甲基)苯基 rac-1-(5,6,7,8-四氫萘-2-基)乙基 4.85[a]
I-353 H Cl [甲醯基(甲基)胺基]甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 3.59[a]
I-354 H 甲基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氰基苯基)-2,2-二氟乙基 3.47[a]
I-355 H Cl H O 3-(三氟甲基)苯基 [1-[3-(三氟甲基)苯基]環丙基]甲基 4.53[a]
(*) I-356 H Cl H O 3-(三氟甲基)苯基 rac-6-甲基-1,2,3,4-四氫萘-1-基 4.51[a]
I-357 H Cl H O 3-(三氟甲基)苯基 2-(4-氯苯基)丙-2-基 4.44[a]
I-358 H 甲基 H O 3-(二氟甲基)-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.83[a]
(*) I-359 H Cl H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.56[a] ;4.46[b]
I-360 H Cl H O 3-(三氟甲基)苯基 2-(2-氯-4-環丙基苯基)-2,2-二氟乙基 4.58[a]
I-361 H Cl 異丙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.93[a]
I-362 H Cl H O 3-環丙基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.87[a]
I-363 H rac-1-羥基乙基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.35[a]
I-364 H Cl H O 3-(三氟甲基)苯基 rac-1-(3-氟-4-甲氧基苯基)乙基 3.69[a]
I-365 H 甲基 H S 3-(二氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.23[a]
I-366 H Cl H O 3-(三氟甲基)苯基 2-(4-氯-2-甲基苯基)-2-氟乙基 4.37[a]
(*) I-367 H Cl H O 3-環丙基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.68[a]
I-368 H Cl H O 3-(三氟甲基)苯基 2-(4-氰基苯基)丙-2-基 3.67[a]
I-369 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.65[a]
I-370 H 甲基 H S 3-環丙基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.72[a]
I-371 H 甲基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.24[a]
I-372 H Cl H O 3-(三氟甲基)苯基 2-(4-溴-2-甲基苯基)-2-氟乙基 4.46[a]
I-373 H Cl H O 3-(三氟甲基)苯基 rac-1-(3,4-二甲基苯基)乙基 4.39[a]
I-374 H 甲基 H O 3-(二氟甲基)-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.74[a]
I-375 H 甲基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.68[a]
I-376 H Cl H O 3-(三氟甲基)苯基 [1-(4-溴-2-氯苯基)環丙基]甲基 5.14[a]
I-377 H Cl H O 3-(三氟甲基)苯基 2-氟-2-(4-氟苯基)乙基 3.63[a]
(*) I-378 H Cl H O 3-(三氟甲基)苯基 rac-2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 4.66[a]
I-379 H Cl H O 3-(三氟甲基)苯基 異喹啉-4-基甲基 2.14[a]
(*) I-380 H 甲基 H O 3-(三氟甲基)苯基 2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 4.18[a]
I-381 H 吡啶-4-基 環丙基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.07[a]
I-382 H Cl H O 3-甲氧基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.97[a]
I-383 H Cl 2-吡咯烷-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.16[a]
I-384 H Cl H O 3-(三氟甲基)苯基 2-(4-甲氧基苯基)丙-2-基 4.03[a]
I-385 H 甲基 H O 3-(二氟甲基)-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.72[a]
I-386 H Cl 甲基 O 3-(三氟甲基)苯基 rac-1-(1-甲基-1H-吲哚-3-基)乙基 3.90[a]
I-387 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-[2-甲基-4-(三氟甲基)苯基]乙基 4.51[a]
I-388 H Cl H O 3-(三氟甲基)苯基 2-氟-2-(4-碘基苯基)乙基 4.23[a]
I-389 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.67[a]
I-390 H Cl H O 3-(三氟甲基)苯基 喹啉-5-基甲基 2.25[a]
I-391 H H 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.67[a]
(*) I-392 H 甲基 H O 3-(三氟甲基)苯基 2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 4.18[a]
I-393 H 甲基 H O 3-(三氟甲基)苯基 rac-6-甲基-1,2,3,4-四氫萘-1-基 4.05[a]
I-394 H Cl H O 3-(三氟甲基)苯基 rac-1-(1,3-苯并間二氧雜環戊烯-5-基)乙基 3.64[a]
I-395 H 甲基 H O 3-(二氟甲基)-2-氟苯基 2-(5-氯吡啶-2-基)-2,2-二氟乙基 3.02[a]
I-396 H 甲基 H O 3-(三氟甲基)苯基 2,2-二氟-2-苯基乙基 3.28[a]
I-397 H Cl H O 3-(三氟甲基)苯基 [1-(2,4-二甲基苯基)環丙基]甲基 4.90[a]
I-398 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.37[a]
I-399 H Cl H O 3-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.16[a]
I-400 H 甲基 環丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.42[a]
I-401 H H H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.99[a]
I-402 H Cl H O 3-(三氟甲基)苯基 rac-1-(2,3-二氫-1-苯并呋喃-5-基)乙基 3.71[a]
I-403 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.63[a]
I-404 H Cl H O 3-(三氟甲基)苯基 2-(4-溴-2-甲基苯基)-2,2-二氟乙基 4.57[a]
I-405 H Cl H O 3-(二氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.16[a]
I-406 H Cl H O 3-(三氟甲基)苯基 2-氟-2-[4-(三氟甲基)苯基]乙基 4.08[a]
(*) I-407 H Cl H O 2,3-二氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.26[a]
I-408 H Cl 氧雜環丁-3-基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.85[a] ;3.94[b]
I-409 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 2-(2,4-二氯苯基)乙基 3.52[a]
I-410 H 甲基 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.92[a]
I-411 H 甲基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.00[a]
I-412 H Cl H O 3-(三氟甲基)苯基 [1-(3-甲基苯基)環丙基]甲基 4.59[a]
I-413 H Cl H O 3-氯-4-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.44[a]
I-414 H Cl H O 3-(三氟甲基)苯基 rac-1-(3,4-二氟苯基)乙基 3.92[a]
I-415 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.50[a]
I-416 H 甲基 H O 3-(三氟甲基)苯基 2-(5-溴-3-氯吡啶-2-基)-2,2-二氟乙基 3.85[a]
I-417 H Cl H O 3-硝基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.01[a]
I-418 H Cl H O 3-(三氟甲基)苯基 2-[2-氯-4-(三氟甲基)苯基]-2,2-二氟乙基 4.45[a]
I-419 H Cl I O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.49[a]
I-420 H Cl H O 3-(三氟甲基)苯基 rac-6-溴-1,2,3,4-四氫萘-1-基 4.72[a] ;4.64[b]
I-421 H Cl H O 3-溴-4-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.56[a]
I-422 H Cl 2-甲氧基乙氧基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.23[a]
(*) I-423 H 甲基 甲基 O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.79[a]
I-424 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.59[a]
I-425 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-[4-(三氟甲基)苯基]乙基 4.17[a]
I-426 H Cl H O 3-(三氟甲基)苯基 2-[2-氯-4-(三氟甲基)苯氧基]乙基 4.34[a]
I-427 H Cl H O 3-氯-4-甲基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.76[a]
I-428 H 甲基 甲基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.04[a]
I-429 H Cl H O 3-溴-5-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.70[a]
I-430 H Cl 吡啶-2-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.26[a]
I-431 H 1-羥基亞胺基乙基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.24[a]
I-432 H H 1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.01[a] ;4.12[b]
I-433 H Cl H O 3-(三氟甲基)苯基 2-(4-甲基苯基)丙-2-基 4.41[a]
I-434 H Cl 氮雜環丁烷-3-基氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 2.40[a]
I-435 H 甲基 H O 3-(三氟甲基)苯基 2,2-二氟-2-[2-甲基-4-(三氟甲基)苯基]乙基 4.17[a]
I-436 H Cl H O 3-(三氟甲基)苯基 [rac-吲哚啉-3-基]甲基 2.42[a]
I-437 H Cl H O 4-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.51[a]
(*) I-438 H Cl H O 3-(三氟甲基)苯基 螺[環丙-2,1'-二氫茚]-1-基 4.27[a]
I-439 H Cl H O 3-(三氟甲基)苯基 [rac-5-溴二氫茚-1-基]甲基 4.61[a] ;4.56[b]
I-440 H H 1,3-噻唑-4-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.05[a] ;4.08[b]
I-441 H Cl H O 3-(二氟甲基)-2-氟苯基 2-(4-溴苯基)-2,2-二氟乙基 3.96[a]
I-442 H Cl 乙基硫基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.87[a]
I-443 H Cl 甲基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)乙基 4.51[a]
I-444 H Cl H O 3-(三氟甲基)苯基 rac-1-(4-溴苯基)乙基 4.30[a]
I-445 H 乙基 甲基 O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.25[a]
I-446 H Cl H O 3-(二氟甲基)-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.15[a]
I-447 H Cl H O 3-溴苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.59[a]
(*) I-448 H Cl H O 3-(三氟甲基)苯基 螺[環丙-2,1'-二氫茚]-1-基 4.37[a]
I-449 H Cl H O 5-溴吡啶-3-基 2-(4-氯苯基)-2,2-二氟乙基 3.46[a] ;3.37[b]
I-450 H 1-羥基亞胺基乙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.32[a]
I-451 H (1Z)-1-(甲氧基亞胺基)乙基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.40[a]
I-452 H (1Z)-1-(甲氧基亞胺基)乙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.77[a]
I-453 H Cl 甲基 O 3-(三氟甲基)苯基 2-(4-氯苯基)乙基 3.92[a]
I-454 H Cl H O 3-(三氟甲基)苯基 rac-1-(6-甲基萘-2-基)乙基 4.74[a]
I-455 H 乙基 甲基 O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.30[a]
I-456 H Cl H O 3-(二氟甲基)-2-氟苯基 2-(5-氯吡啶-2-基)-2,2-二氟乙基 3.44[a]
I-457 H Cl 甲基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.01[a]
I-458 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2-氟乙基 4.46[a]
I-459 H Cl H O 3-氯苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.44[a]
I-460 H Cl 甲基 O 3-(三氟甲基)苯基 rac-1-(4-甲基苯基)乙基 3.99[a]
I-461 H I H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.67[a]
I-462 H Cl H O 3-氟苯基 2-(4-氯苯基)-2,2-二氟乙基 3.77[a]
I-463 H Cl H O 5-溴吡啶-3-基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.82[a] ;3.75[b]
I-464 H Cl 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)乙基 4.37[a]
I-465 H 3-甲氧基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.94[a]
I-466 H Cl H O 3-(三氟甲基)苯基 rac-1-(3,4-二氯苯基)乙基 4.51[a]
I-467 H Cl H O 3-(二氟甲基)-2-氟苯基 2-(4-氯苯基)-2,2-二氟乙基 3.90[a]
I-468 H Cl H O 3-環丙基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.67[a]
I-469 H Cl 甲氧基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.61[a]
I-470 H Cl H O 2,3-二氟苯基 2-(4-氯苯基)-2,2-二氟乙基 3.83[a]
I-471 H Cl H O 5-溴吡啶-3-基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.92[a] ;4.84[b]
I-472 H Cl H O 3-(三氟甲基)苯基 2-(2-氯-4-丙-1-烯-2-基苯基)-2,2-二氟乙基 4.80[a] ;4.76[b]
I-473 H (1E)-1-(甲氧基亞胺基)乙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 5.30[a]
I-474 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 rac-2-(4-氯苯基)-2-氟乙基 4.15[a]
I-475 H 3-甲氧基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.87[a]
I-476 H Cl H O 3-(三氟甲基)苯基 2-(4-氟苯基)丙-2-基 4.11[a]
I-477 H 甲基 H O 3-(二氟甲基)-2-氟苯基 2-(4-溴苯基)-2,2-二氟乙基 3.55[a]
I-478 H Cl H O 3-(三氟甲基)苯基 2-(2-溴-4-氯苯基)-2,2-二氟乙基 4.68[a]
I-479 H Cl H O 3-(三氟甲基)苯基 2-(6-氯吡啶-3-基)-2,2-二氟乙基 3.42[a]
I-480 H Cl H O 3-乙炔基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.15[a]
I-481 H 甲基 H O 3-(二氟甲基)苯基 rac-2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 3.74[a]
I-482 H Cl H O 3-溴-5-氟苯基 2-(4-氯苯基)-2,2-二氟乙基 4.27[a]
I-483 H Cl H O 5-溴吡啶-3-基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.87[a] ;3.80[b]
I-484 H Cl 環丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲氧基苯基)乙基 3.44[a]
I-485 H Cl 3-羧基丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.50[a]
I-486 H 3-甲氧基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(4-溴苯基)-2,2-二氟乙基 3.60[a]
I-487 H Cl H O 3-(三氟甲基)苯基 rac-1-(3-氯苯基)乙基 4.13[a]
I-488 H CN H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.30[a]
I-489 H Cl H O 3-(三氟甲基)苯基 [rac-𠳭烷-4-基]甲基 3.94[a]
I-490 H Cl H O 3-(三氟甲氧基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.63[a]
I-491 H Cl H O 3-溴-5-氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.72[a]
I-492 H Cl H O 3-溴-4-氟苯基 2-(4-氯苯基)-2,2-二氟乙基 4.15[a]
I-493 H Cl 環丙基胺基 O 3-(三氟甲基)苯基 rac-2-(4-氯苯基)-2-氟乙基 3.76[a]
I-494 H 3-氯吡啶-4-基 H O 2,3-二氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.13[a]
I-495 H Cl H O 3-(三氟甲基)苯基 rac-1-(4-氟苯基)乙基 3.83[a]
I-496 H Cl H O 3-(三氟甲基)苯基 2-(2-氯-4-甲基苯基)-2,2-二氟乙基 4.28[a]
I-497 H Cl 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.46[a]
I-498 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-(3-氟苯基)乙基 3.89[a]
I-499 H Cl H O 5-(三氟甲基)吡啶-3-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.96[a] ;4.11[b]
I-500 H Cl 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲氧基苯基)乙基 3.65[a]
I-501 H 3-氯吡啶-4-基 H O 2,3-二氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.03[a]
I-502 H Cl H O 3-(三氟甲基)苯基 rac-1-(3-甲氧基苯基)乙基 3.76[a]
I-503 H 甲基 甲基 O 3-環丙基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.92[a]
I-504 H 甲基 H O 3-環丙基-2-氟苯基 rac-1-(1-甲基-1H-吲哚-3-基)乙基 3.72[a]
I-505 H Cl H O 3-(三氟甲基)苯基 2-(4-溴-2-氟苯基)-2,2-二氟乙基 4.17[a]
I-506 H Cl 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.30[a]
I-507 H 1-甲基-1H-咪唑-5-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 2.62[a]
I-508 H Cl H O 5-氯吡啶-3-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.72[a] ;3.87[b]
I-509 H (1Z)-1-(甲氧基亞胺基)乙基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.82[a]
I-510 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(4-氯苯基)-2-氟乙基 3.92[a]
I-511 H 甲基 H O 3-(三氟甲基)苯基 2,2-二氟-2-(5-甲氧基吡啶-2-基)乙基 2.96[a] ;3.11[b]
I-512 H 3-氯吡啶-4-基 H O 2,3-二氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.18[a]
I-513 H 甲基 H O 3-環丙基-2-氟苯基 rac-1-(1,5-二甲基-1H-吲哚-3-基)乙基 4.03[a]
I-514 H Cl H O 3-(三氟甲基)苯基 2-(4-溴苯基)-2,2-二氟乙基 4.11[a]
I-515 H 1H-吡唑-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.65[a]
I-516 H Cl 甲基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.64[a]
I-517 H Cl H O 3-(三氟甲基)苯基 [rac-1,2,3,4-四氫萘-1-基]甲基 4.61[a]
I-518 H Cl H O 5-氟吡啶-3-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.37[a] ;3.55[b]
I-519 H Cl H O 3-(三氟甲基)苯基 2-(4-乙炔基-2-甲基苯基)-2,2-二氟乙基 4.32[a]
I-520 H Cl H O 3-氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.20[a]
I-521 H Cl H O 3-氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.13[a]
I-522 H Cl 環丙基胺基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.41[a]
I-523 H (1E)-1-(甲氧基亞胺基)乙基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 5.20[a]
I-524 H Cl 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(2,4-二甲氧基苯基)乙基 3.85[a]
I-525 H 甲基 H O 3-(三氟甲基)苯基 2-[5-(二氟甲基)吡啶-2-基]乙基 2.57[a] ;2.71[b]
I-526 H 3-氯吡啶-4-基 H O 2,3-二氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.08[a]
I-527 H Cl H O 3-(三氟甲基)苯基 3-(4-甲基苯基)氧雜環丁-3-基 3.69[a]
I-528 H 甲基 H O 3-環丙基-2-氟苯基 rac-1-(6-氯-1-甲基-1H-吲哚-3-基)乙基 4.12[a]
I-529 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-(2-甲基苯基)乙基 4.16[a]
I-530 H Cl H O 2,3-二氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.27[a]
I-531 H Cl H O 2,3-二氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.18[a]
I-532 H 3-氯吡啶-4-基 H O 2,3-二氟苯基 2-(4-溴苯基)-2,2-二氟乙基 3.83[a]
(*) I-533 H Cl 甲基 O 3-甲氧基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.85[a]
I-534 H Cl 甲基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.18[a]
I-535 H Cl H O 3-溴-5-氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.64[a]
I-536 H 甲基 H O 3-環丙基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.05[a]
I-537 H 3-甲基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.58[a]
I-538 H Cl H O 3-(三氟甲基)苯基 2-(3,4-二氯苯基)-2,2-二氟乙基 4.51[a]
I-539 H Cl H O 3-(三氟甲基)苯基 1-喹啉-2-基乙基 4.24[a]
I-540 H Cl H O 3-溴-4-氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.51[a]
I-541 H Cl H O 3-(三氟甲基)苯基 2-(1,3-苯并間二氧雜環戊烯-5-基)乙基 3.55[a]
I-542 H Cl H O 3-(三氟甲基)苯基 2-(4-吡啶-4-基苯基)乙基 2.13[a]
I-543 H 甲基 H O 3-(三氟甲基)苯基 2-(2-甲基-1,3-苯并噁唑-4-基)乙基 2.96[a]
I-544 H 甲基 H O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.14[a]
I-545 H 3-甲基吡啶-4-基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.46[a]
I-546 H Cl 4-甲氧基-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.36[a]
I-547 H Cl 甲基 O 3-(三氟甲基)苯基 rac-1-(6-氯-1-甲基-1H-吲哚-3-基)乙基 4.24[a]
I-548 H Cl H O 3-(三氟甲基)苯基 2-(3-溴-2-氯苯基)-2,2-二氟乙基 4.59[a]
I-549 H Cl 甲基 O 3-(三氟甲基)苯基 2,2-二氟-2-(3-甲基苯基)乙基 4.11[a]
I-550 H Cl 吡啶-3-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.99[a]
I-551 H Cl H O 3-(三氟甲基)苯基 2-(2,3-二氫-1-苯并呋喃-5-基)乙基 3.65[a]
I-552 H rac-1-氟乙基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯-苯基)-2-氟乙基 4.67[a]
I-553 H 3-甲基吡啶-4-基 H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.37[a]
I-554 H Cl 環丙基氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.72[a]
I-555 H Cl 甲基 O 3-環丙基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.56[a]
I-556 H 甲基 甲基 O 3-環丙基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.83[a]
I-557 H 甲基 甲基 O 3-氯苯基 rac-1-(1-甲基-1H-吲哚-3-基)乙基 3.06[a]
I-558 H Cl H O 3-(三氟甲基)苯基 異喹啉-3-基甲基 3.06[a]
I-559 H Cl H O 3-(三氟甲基)苯基 異喹啉-5-基甲基 2.14[a]
I-560 H Cl H O 3-(三氟甲基)苯基 2-(6-異丙基氧基吡啶-3-基)乙基 3.76[a]
I-561 H 甲基 H O 3-甲氧基苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.58[a]
I-562 H 3-甲基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.48[a]
I-563 H 甲基 H O 2-氟-3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.23[a]
I-564 H 甲基 H O 3-環丁基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.85[a]
I-565 H Cl 4-氯-1H-吡唑-1-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.80[a]
I-566 H 甲基 甲基 O 3-環丙基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.81[a]
I-567 H Cl H O 2,2-二氟-1,3-苯并間二氧雜環戊烯-5-基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.56[a]
I-568 H Cl H O 3-(三氟甲基)苯基 2-苯氧基乙基 3.58[a]
I-569 H Cl 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氟苯基)-2,2-二氟乙基 3.90[a]
I-570 H Cl H O 3-乙基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.68[a]
I-571 H Cl H O 3-(三氟甲基)苯基 2-(2,4-二甲氧基苯基)乙基 3.92[b]
I-572 H 環丙基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.41[a]
I-573 H Cl H O 3-(三氟甲基)苯基 2-(2,3-二氫-1,4-苯并二氧雜環己烯-6-基)乙基 3.53[a]
I-574 H 甲基 H O 3-環丙基苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.28[a]
I-575 H 3-甲基吡啶-4-基 H O 3-(三氟甲基)苯基 2-(4-溴苯基)-2,2-二氟乙基 3.23[a]
I-576 H 甲基 H O 3-(三氟甲基)苯基 2-[2-氯-4-(氧雜環丁-3-基)苯基]-2,2-二氟乙基 3.15[a]
I-577 H 乙炔基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.31[a]
I-578 H Cl H O 3-溴苯基 2,2-二氟-2-(5-甲氧基吡啶-2-基)乙基 3.33[a] ;2.99[b]
I-579 H 甲基 H O 3-環丙基-2-氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.34[a]
I-580 H 3-甲氧基吡啶-4-基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.87[a]
I-581 H 甲基 H O 3-環丙基-2-氟苯基 2-[5-(二氟甲基)吡啶-2-基]乙基 2.80[b]
I-582 H 甲基 H O 3-(三氟甲基)苯基 rac-6-(氧雜環丁-3-基)-1,2,3,4-四氫萘-1-基 3.21[a]
I-583 H Cl H O 3-(三氟甲基)苯基 [3-(三氟甲基)苯基]甲基 3.99[a]
I-584 H 乙炔基 H O 3-(三氟甲基)苯基 2-(4-乙炔基-2-甲基苯基)-2,2-二氟乙基 4.08[a]
I-585 H Cl H O 3-(三氟甲基)苯基 rac-3-(三氟甲基)-5,6,7,8-四氫喹啉-8-基 4.04[a] ;4.14[b]
I-586 H Cl H O 3-溴苯基 2-(2,3-二氫-1,4-苯并二氧雜環己烯-5-基)乙基 3.72[a]
I-587 H Cl H O 3-環丙基苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.65[a]
I-588 H 3-甲氧基吡啶-4-基 H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.76[a]
I-589 H CHF2 H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.49[a]
I-590 H 甲基 甲基 O 2-氟-3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.92[a]
I-591 H Cl H O 2-氟-3-甲氧基苯基 rac-6-溴-1,2,3,4-四氫萘-1-基 4.32[a]
I-592 H 甲基 H O 3-(三氟甲基)苯基 rac-6-環丁基-1,2,3,4-四氫萘-1-基 5.08[a]
I-593 H Cl H O 3-(三氟甲基)苯基 rac-4,5,6,7-四氫-1-苯并噻吩-7-基 3.99[a]
(*) I-594 H Cl H O 3-環丙基-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.80[a]
I-595 H H CHF2 O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.24[a]
I-596 H 乙基 Cl O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)乙基 4.51[a]
I-597 H 乙醯基 H O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.02[a]
I-598 H Cl H O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.71[a]
I-599 H 3-氯吡啶-4-基 H O 3-(三氟甲基)苯基 2-(4-溴苯基)-2,2-二氟乙基 4.18[a]
I-600 H Cl H O 3-甲氧基苯基 2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 4.18[a]
I-601 H Cl H O 3-(三氟甲基)苯基 [1-(4-甲基苯基)環丙基]甲基 4.58[a]
I-602 H Cl H O 3-(三氟甲基)苯基 2-[2-(1-甲基-1H-三唑-4-基)苯基]乙基 3.25[a]
I-603 H Cl H O 3-(三氟甲基)苯基 萘-2-基甲基 4.23[a]
I-604 H 甲基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.65[a]
I-605 H 乙醯基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.49[a]
(*) I-606 H 甲基 H O 3-(三氟甲基)苯基 rac-2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 4.20[a]
I-607 H Cl H O 3-環丙基-2-氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.82[a]
I-608 H Cl H O 2-氟-3-甲氧基苯基 2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 4.18[a]
I-609 H Cl H O 3-(三氟甲基)苯基 2-[4-(二氟甲氧基)苯基]乙基 3.85[a]
I-610 H 甲基 吡啶-2-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.85[a] ;3.96[b]
I-611 H Cl H O 3-(三氟甲基)苯基 2-(4-甲基-2-吡啶-2-基苯基)乙基 3.81[a]
I-612 H 甲基 H O 3-環丙基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.29[a]
I-613 H 甲基 H O 3-環丙基-2-氟苯基 2-(2-甲基-1,3-苯并噁唑-4-基)乙基 3.06[a]
I-614 H 甲基 H O 3-(三氟甲基)苯基 rac-6-(氧雜環己烷-4-基)-1,2,3,4-四氫萘-1-基 3.83[a]
I-615 H Cl H O 3-(三氟甲基)苯基 2-(2,3-二甲基苯基)-2,2-二氟乙基 4.46[a]
I-616 H Cl H O 3-(二氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 3.85[a]
I-617 H Cl H O 3-(三氟甲基)苯基 rac-2-甲基-4,5,6,7-四氫-1-苯并噻吩-7-基 4.36[a]
I-618 H Cl H O 3-甲氧基苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.27[a]
I-619 H Cl H O 3-(二氟甲基)-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.18[a]
I-620 H 甲基 H O 3-環丙基苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.26[a]
I-621 H 甲基 H O 3-(三氟甲基)苯基 rac-6-環丙基-1,2,3,4-四氫萘-1-基 4.32[a]
I-622 H Cl H O 3-(三氟甲基)苯基 2-(3,4-二甲基苯基)-2,2-二氟乙基 4.44[a]
I-623 H 3-氯吡啶-4-基 H O 2,3-二氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.01[a]
I-624 H Cl H O 3-(三氟甲基)苯基 2-(2-環丙基-4-甲基苯基)乙基 4.76[a]
I-625 H 甲基 H O 3-環丙基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.14[a]
I-626 H Cl H O 2-氟-3-甲氧基苯基 rac-7-溴-1,2,3,4-四氫萘-1-基 4.13[a]
I-627 H Cl H O 3-(三氟甲基)苯基 2,2-二氟-2-(2-氟-4,6-二甲基苯基)乙基 4.34[a]
I-628 H 甲基 H O 3-(三氟甲基)苯基 2-[2-(三氟甲基)苯基]環丙基 3.77[a]
I-629 H Cl H O 3-甲氧基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.23[a]
I-630 H Cl H O 3-(二氟甲基)-2-氟苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.20[a]
I-631 H Cl H O 3-(三氟甲基)苯基 2-(2-乙炔基-4-甲基苯基)乙基 4.24[a]
I-632 H 甲基 H O 3-環丙基-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.36[a]
I-633 H Cl H O 3-(三氟甲基)苯基 2-[2-氯-4-(三氟甲基)苯氧基]-2,2-二氟乙基 4.58[a]
I-634 H 甲基 H O 3-(三氟甲基)苯基 1-[(4-氯苯基)甲基]環丙基 3.73[a]
I-635 H Cl H O 3-(三氟甲基)苯基 2-(5-氯嘧啶-2-基)乙基 3.05[a]
I-636 H 環丙基 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.57[a]
(*) I-637 H Cl H O 3-(二氟甲基)-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.08[a]
I-638 H 甲基 H O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.34[a]
I-639 H Cl H O 3-(三氟甲基)苯基 rac-2-氯-4,5,6,7-四氫-1-苯并噻吩-4-基 4.68[a]
I-640 H Cl H O 3-環丙基苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.90[a]
I-641 H 甲基 H O 3-(三氟甲基)苯基 1-[(4-甲氧基苯基)甲基]環丙基 3.30[a]
I-642 H 環丙基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.43[a]
I-643 H 3-氯吡啶-4-基 H O 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.41[a]
I-644 H 甲基 H O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.21[a]
I-645 H Cl 環丙基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.21[a]
I-646 H Cl H O 2,3-二氟苯基 1-[3-(三氟甲基)苯基]乙基 3.76[a]
I-647 H Cl H O 3-(三氟甲基)苯基 rac-2-(4-氯苯基)-2-氟環丙基 4.11[a]
I-648 H Cl 環丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.19[a]
I-649 H 吡啶-4-基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.44[a]
I-650 H 環丙基 環丙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.10[a]
I-651 H 3-氯吡啶-4-基 H O 3-(三氟甲基)苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.49[a]
I-652 H Cl H O 5-環丙基吡啶-3-基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.63[a] ;3.94[b]
I-653 H H 2-甲氧基乙基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.94[a]
I-654 H 3-氯吡啶-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 4.46[a]
I-655 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.49[a]
I-656 H Cl H O 2-氟-3-甲氧基苯基 rac-2-甲基-4,5,6,7-四氫-1-苯并噻吩-7-基 3.96[a]
I-657 H Cl 異丙基 O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 5.17[a]
I-658 H Cl H O 5-環丙基吡啶-3-基 2-(4-氯苯基)-2,2-二氟乙基 3.19[a] ;3.50[b]
I-659 H 吡啶-4-基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2,2-二氟乙基 3.55[a]
I-660 H 3-氯吡啶-4-基 環丙基胺基 O 3-(三氟甲基)苯基 2-(4-氯苯基)-2,2-二氟乙基 4.03[a] ;4.15[b]
I-661 H 3-氯吡啶-4-基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2,2-二氟乙基 4.54[a]
I-662 H 2-氰基乙基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.78[a]
I-663 H Cl 甲基 O 3-溴-2-氟苯基 rac-2-(2-氯-4-環丙基苯基)-2-氟乙基 4.55[a]
I-664 H Cl F O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.74[a]
I-665 H Cl H O 3-(1-氟環丙基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.56[a]
I-666 H Cl H O 3-(rac-2,2-二氟環丙基)苯基 2-(2,4-二甲基苯基)乙基 4.39[a]
I-667 H Cl 甲基 O 3-溴-2-氟苯基 2-(2-氯-4-甲基苯基)-2,2-二氟乙基 4.33[a]
I-668 H Cl 甲基 O 3-溴-2-氟苯基 2-(4-溴-2-甲基苯基)-2,2-二氟乙基 4.59[a]
I-669 H Cl 甲基 O 3-溴-2-氟苯基 rac-2-(2-氯-4-甲基苯基)-2-氟乙基 4.26[a]
I-670 H Cl 甲基 O 3-溴-2-氟苯基 rac-2-(2,4-二甲基苯基)-2-氟乙基 4.23[a]
I-671 H Cl 甲基 O 3-溴-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.47[a]
I-672 H Cl H O 3-(3-氟丙-1-烯-2-基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.39[a]
I-673 H 甲基 H O 3-(三氟甲基)苯基 (2,4-二甲基苯氧基)甲基 3.79[a]
I-674 H 甲基 H O 3-(三氟甲基)苯基 (4-氯苯氧基)甲基 3.55[a]
I-675 H Cl H O 3-乙炔基-2-氟苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.30[a]
I-676 H Cl H O 2-氟-3-丙-1-烯-1-基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 5.00[a]
I-677 H Cl H O 3-乙炔基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.18[a]
I-678 H Cl H O 5-(二氟甲基)吡啶-3-基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.54[a]
I-679 H Cl 4-羧基丁基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.81[a]
I-680 H Cl H O 5-(二氟甲基)吡啶-3-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.46[a]
I-681 H Cl H O 3-乙炔基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.13[a]
I-682 H Cl H O 5-(三氟甲基)-3-噻吩基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.72[a]
I-683 H Cl rac-(2,2-二氟環丙基)甲氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.95[a]
I-684 H Cl 烯丙氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.87[a]
I-685 H (環丙基胺基)羰基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.39[a]
I-686 H Cl H O 2-氟-3-[rac-環氧乙烷-2-基]苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.96[a]
I-687 H Cl 2-乙氧基乙氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.72[a]
I-688 H Cl (E)-4,4,4-三氟丁-2-烯氧基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 5.14[a]
I-689 CN Cl 甲基 O 3-(三氟甲基)苯基 2-(4-氯苯基)乙基 4.77[a]
I-690 H Cl 甲基 O 5-(二氟甲基)吡啶-3-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.46[a]
I-691 H 甲基 H O 3-(三氟甲基)苯基 2-(4-甲基-1H-吡唑-1-基)乙基 2.58[a]
I-692 H Cl 甲基 O 2-氟-3-乙烯基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.41[a]
I-693 H Cl 甲基 O 3-(1-氟環丙基)苯基 2-(2,4-二甲基苯基)乙基 4.20[a]
I-694 H Cl 甲基 O 3-(rac-2,2-二氟環丙基)苯基 2-(2,4-二甲基苯基)乙基 4.13[a]
I-695 H Cl 甲基 O 3-(rac-2,2-二氟環丙基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.30[a]
I-696 H Cl 甲基 O 3-(rac-2,2-二氟環丙基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.27[a]
I-697 OH Cl H O 3-(三氟甲基)苯基 2-(4-氯苯基)乙基 3.74[a]
I-698 H Cl H O 2-氟-3-[rac-環氧乙烷-2-基]苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.15[a]
(*) I-699 H Cl H O 3-(rac-2-氟環丙基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.47[a]
(*) I-700 H Cl H O 3-(rac-2-氟環丙基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-701 H Cl H O 2-氟-3-[rac-環氧乙烷-2-基]苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.08[a]
I-702 H 甲基 (2-甲基-1,3-二氧戊環-4-基)甲基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.82[a]
(*) I-703 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)-2-氟乙基 4.51[a]
(*) I-704 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)-2-氟乙基 4.51[a]
(*) I-705 H 環丙基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2-氟乙基 4.85[a]
(*) I-706 H 環丙基 H O 3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2-氟乙基 4.85[a]
I-707 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(3,4-二甲基苯基)-2-氟乙基 4.30[a]
I-708 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-[4-(二氟甲基)-2-甲基苯基]-2-氟乙基 4.05[a]
I-709 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(2-氯-4-甲基苯基)-2-氟乙基 4.40[a]
I-710 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(4-氯-2-甲基苯基)-2-氟乙基 4.44[a]
I-711 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(2-氯-4-環丙基苯基)-2-氟乙基 4.70[a]
I-712 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(4-溴-2-甲基苯基)-2-氟乙基 4.55[a]
I-713 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(3,4-二甲基苯基)-2-氟乙基 4.40[a]
I-714 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-[4-(二氟甲基)-2-甲基苯基]-2-氟乙基 4.12[a]
I-715 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(4-氯-3-甲氧基苯基)-2-氟乙基 4.08[a]
I-716 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(3,4-二氯苯基)-2-氟乙基 4.51[a]
I-717 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(2-氯-4-甲基苯基)-2-氟乙基 4.47[a]
I-718 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(4-氯-2-甲基苯基)-2-氟乙基 4.55[a]
I-719 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(2-氯-4-環丙基苯基)-2-氟乙基 4.78[a]
I-720 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(4-溴-2-甲基苯基)-2-氟乙基 4.66[a]
(*) I-721 H Cl H O 3-環丙基-2-氟苯基 2-(4-溴-2-氯苯基)-2-氟乙基 5.00[a]
(*) I-722 H Cl H O 3-環丙基-2-氟苯基 2-(4-溴-2-氯苯基)-2-氟乙基 5.00[a]
(*) I-723 H Cl 甲基 O 3-甲氧基苯基 2-(2,4-二氯苯基)-2-氟乙基 3.94[a]
(*) I-724 H Cl 甲基 O 3-甲氧基苯基 2-(2,4-二氯苯基)-2-氟乙基 3.94[a]
(*) I-725 H 甲基 甲基 O 3-氯苯基 2-(4-溴-2-氯苯基)-2-氟乙基 3.81[a]
(*) I-726 H 甲基 甲基 O 3-氯苯基 2-(4-溴-2-氯苯基)-2-氟乙基 3.81[a]
I-727 H Cl H O 1-苯并噻吩-6-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.47[a]
I-728 H Cl H O 6,7-二氫-5H-環戊并[b]吡啶-3-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.40[a]
(*) I-729 H Cl H O 2,3-二氟苯基 2-(4-溴-2-氯苯基)-2-氟乙基 4.37[a]
(*) I-730 H Cl H O 2,3-二氟苯基 2-(4-溴-2-氯苯基)-2-氟乙基 4.37[a]
I-731 H Cl H O 3-乙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.85[a]
I-732 H Cl H O rac-二氫茚-1-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 5.16[a]
(*) I-733 H Cl H O 3-環丙基苯基 2-(2,4-二氯苯基)-2-氟乙基 4.85[a]
(*) I-734 H Cl H O 3-環丙基苯基 2-(2,4-二氯苯基)-2-氟乙基 4.85[a]
(*) I-735 H 甲基 H O 2-氟-3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2-氟乙基 4.33[a]
(*) I-736 H 甲基 H O 2-氟-3-(三氟甲基)苯基 2-(4-溴-2-氯苯基)-2-氟乙基 4.33[a]
I-737 H Cl 甲基 O 2-氟-3-[rac-2,2-二氟環丙基]苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-738 H Cl 甲基 O 2-氟-3-[rac-2,2-二氟環丙基]苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.33[a]
I-739 甲氧基 Cl 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)乙基 5.36[a]
I-740 甲氧基 Cl H O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)乙基 5.12[a]
(*) I-741 H 甲基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2-氟乙基 3.88[a]
(*) I-742 H 甲基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二氯苯基)-2-氟乙基 3.88[a]
(*) I-743 H Cl H O 3-(二氟甲基)-2-氟苯基 2-(2,4-二氯苯基)-2-氟乙基 4.26[a]
(*) I-744 H Cl H O 3-(二氟甲基)-2-氟苯基 2-(2,4-二氯苯基)-2-氟乙基 4.26[a]
I-745 甲氧基甲基 甲基 H O 3-環丙基苯基 2-(2,4-二甲基苯基)乙基 4.26[a]
I-746 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(2-氯-4-甲基苯基)-2,2-二氟乙基 4.55[a]
I-747 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(4-氯-2-甲基苯基)-2,2-二氟乙基 4.74[a]
I-748 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(4-溴-2-甲基苯基)-2,2-二氟乙基 4.81[a]
I-749 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(3,4-二甲基苯基)-2,2-二氟乙基 4.51[a]
I-750 H Cl 甲基 O 3-(二氟甲基)-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.19[a]
I-751 H Cl I O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.67[a]
I-752 乙氧基 Cl 甲基 O 3-環丙基-2-氟苯基 苯甲基 4.55[a]
I-753 2-甲基丙氧基 Cl 甲基 O 3-環丙基-2-氟苯基 苯甲基 5.20[a]
I-754 H 甲基 H O 3-環丙基苯基 rac-1-氰基-2-(2,4-二甲基苯基)乙基 3.94[a]
I-755 H 氧雜環己烷-4-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.11[a]
I-756 H Cl 環丙基胺基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.34[a]
I-757 H Cl 甲基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)乙基 4.09[a]
I-758 H Cl I O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.73[a]
I-759 H Cl I O 3-環丙基-2-氟苯基 2-(2,4-二氯苯基)乙基 4.81[a]
I-760 H 甲基 環丙基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.68[a]
I-761 H Cl 甲基胺基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.11[a]
I-762 H Cl H O 3-環丙基-2-氟苯基 rac-2-(2,4-二甲基苯基)-2-氟乙基 4.61[a]
I-763 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-(2,4-二甲基苯基)-2-氟乙基 4.25[a]
I-764 H Cl H O 2-氟-3-(1-氟環丙基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.55[a]
I-765 H Cl H O 2-氟-3-(1-氟環丙基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.59[a]
I-766 H Cl 甲基 O 2-氟-3-(1-氟環丙基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.40[a]
I-767 H 甲基硫基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.72[a]
I-768 H 乙基硫基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 5.08[a]
I-769 H Cl H O 1H-吲哚-5-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.78[a]
I-770 H Cl H O 3-乙炔基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.30[a]
I-771 H rac-乙基亞磺醯基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.83[a]
I-772 H 甲基 H O 3-(三氟甲基)苯基 (Z)-2-(2,4-二甲基苯基)乙烯-1-基 4.54[a]
I-773 H Cl 甲基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二甲基苯基)-2-氟乙基 4.37[a]
I-774 H I 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.59[a]
I-775 H 甲基 甲基胺基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.29[a]
I-776 H 甲基 甲基胺基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 3.31[a]
I-777 H Cl 甲基 O 3-(三氟甲基)苯基 2-(4,5-二甲基-3-噻吩基)乙基 4.08[a]
I-778 H Cl 甲基 O 3-(三氟甲基)苯基 rac-2-甲基-4,5,6,7-四氫-1-苯并噻吩-7-基 4.30[a]
I-779 H 甲基 甲氧基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.01[a]
I-780 H Cl H O 2-氟-3-乙烯基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.53[a]
I-781 H rac-甲基亞磺醯基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.65[a]
I-782 H Cl OH O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 5.13[a]
I-783 H Cl 甲氧基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.51[a]
I-784 H Cl 甲基 O 3-氯-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-785 丙-1-烯-2-基氧基羰基 Cl H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 5.51[a]
I-786 H Cl 甲基 O 3-氯-2-氟苯基 2-(4-環丙基-2-甲基苯基)-2,2-二氟乙基 4.62[a]
I-787 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(2,4-二甲基苯基)乙基 4.44[a]
I-788 H Cl 甲基 O 3-氯-2-氟苯基 2-(2-氯-4-甲基苯基)-2,2-二氟乙基 4.26[a]
I-789 H Cl 甲基 O 3-氯-2-氟苯基 2-(4-氯-2-甲基苯基)-2,2-二氟乙基 4.47[a]
I-790 H Cl 甲基 O 3-氯苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.27[a]
I-791 H Cl H O 2-氟-3-乙烯基苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.63[a]
I-792 H Cl H O 3-乙醯基苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.81[a]
I-793 H 1-(第三-丁氧基羰基)氮雜環丁烷-3-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.64[a]
I-794 H rac-氧戊環-3-基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.78[a]
I-795 H 3,3,3-三氟丙基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.51[a]
I-796 H 2-甲氧基乙基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.00[a]
I-797 H 苯甲基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.95[a]
I-798 H 環丁基甲基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 5.02[a]
I-799 H (環丙基胺基)羰基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.92[a]
I-800 H 甲基 甲基 S 3-(三氟甲基)苯基 rac-2-(2,4-二氯苯基)-2-氟乙基 4.63[a]
I-801 H 丙基胺基羰基 甲基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.25[a]
I-802 H 2-羥基乙基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.35[a]
I-803 H 3-乙氧基-3-氧基丙基 H O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-804 H Cl 2-甲基硫基乙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.56[a]
I-805 H Cl (2-甲基-1,3-二氧戊環-4-基)甲基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-806 H Cl rac-丁-3-烯-2-基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.72[a]
I-807 H Cl 2-甲氧基乙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.25[a]
I-808 H Cl 2-甲氧基乙基硫基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.64[a]
I-809 H Cl 2-環丙基乙基胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.95[a]
I-810 H Cl (1-甲基環丙基)胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.56[a]
I-811 H Cl 2,2,2-三氟乙基硫基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.92[a]
I-812 H Cl (2-環丙基環丙基)胺基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.87[a]
I-813 H Cl H O 2,3-二氫-1-苯并呋喃-5-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.96[a]
I-814 H Cl H O 3-(甲氧基甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.99[a]
I-815 H Cl H O 3-氰基-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.79[a]
I-816 H Cl H O 2-氟-3-甲基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-817 H Cl H O 3-甲基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.34[a]
I-818 H Cl H O 2-氟-3-甲基硫基苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.37[a]
I-819 H Cl H O 3-(三氟甲基硫基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.88[a]
I-820 H Cl H O 2-氟-3-(三氟甲氧基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.66[a]
I-821 H Cl 嗎啉-4-基 O 3-(三氟甲基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.27[a]
I-822 H Cl 甲基 O 3-氯苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 4.37[a]
I-823 H 甲基 H O 3-環丙基-2-氟苯基 rac-2-(2,4-二甲基苯基)-2-氟乙基 4.11[a]
I-824 H Cl H O 3-(三氟甲基)苯基 2-(4,5-二甲基-3-噻吩基)乙基 4.32[a]
I-825 H Cl H O 3-(三氟甲基)苯基 2-(2,5-二氯-3-噻吩基)-2,2-二氟乙基 4.73[a]
I-826 H Cl H O 3-(三氟甲基)苯基 2-(5-甲基-2-呋喃基)乙基 3.79[a]
I-827 H 甲基 H O 3-環丙基-2-氟苯基 rac-2-(2,4-二甲基苯基)-2-羥基乙基 3.17[a]
I-828 H Cl H O 5-乙基-2-(甲氧基羰基)-3-噻吩基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.88[a]
I-829 H Cl H O 3-(1-氰基環丙基)-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.94[a]
I-830 H Cl H O 1H-吲哚-6-基 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.90[a]
I-831 H Cl H O 3-(1-氟環丙基)苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.49[a]
I-832 H Cl H O 3-(二氟甲氧基)-2-氟苯基 2-(2,4-二甲基苯基)-2,2-二氟乙基 4.17[a]
I-833 H Cl 甲基 O 3-溴-2-氟苯基 2-(4-環丙基-2-甲基苯基)-2,2-二氟乙基 4.66[a]
(*) I-834 H 甲基 甲基 O 3-氯苯基 rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.69[a]
I-835 H 甲基 甲基 O 3-環丙基-2-氟苯基 rac-2-(2-氯-4-甲基苯基)-2-氟乙基 3.81[a]
I-836 H 甲基 甲基 O 3-環丙基-2-氟苯基 rac-2-(2,4-二甲基苯基)-2-氟乙基 3.78[a]
I-837 H 甲基 甲基 O 3-環丙基-2-氟苯基 rac-2-(2-氯-4-環丙基苯基)-2-氟乙基 4.12[a]
I-838 H 甲基 甲基 O 3-環丙基-2-氟苯基 2-(2-氯-4-甲基苯基)-2,2-二氟乙基 3.91[a]
I-839 H 甲基 甲基 O 3-環丙基-2-氟苯基 2-(3,4-二甲基苯基)-2,2-二氟乙基 3.87[a]
I-840 H Cl 甲基 O 3-環丙基-2-氟苯基 2-(2-溴-4-甲基苯基)-2,2-二氟乙基 4.57[a]
I-841 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 rac-2-(2-氯-4-甲基苯基)-2-氟乙基 3.47[a]
I-842 H 甲基 甲基 O 3-(二氟甲基)-2-氟苯基 2-(4-溴-2-甲基苯基)-2,2-二氟乙基 3.81[a]
I-843 H Cl 甲基 O 3-氯-2-氟苯基 2-(3,4-二甲基苯基)-2,2-二氟乙基 4.25[a]
I-844 H Cl 甲基 O 3-氯-2-氟苯基 2-(2-溴-4-甲基苯基)-2,2-二氟乙基 4.34[a]
(*) 實例 I - 016 及 I - 024 為實例 I - 288 之 2 對映異構體 (*) 實例 I - 142 為實例 I - 359 之 1 對映異構體 實例I-142：旋光度：-46.4° (c=1.04，DCM，25℃)；濃度c以g/100 mL表示。(*) 實例 I - 147 為實例 I - 378 之 1 對映異構體 實例I-147：旋光度：+18°(c=1，MeOH，20℃)；濃度c以g/100 mL表示。(*) 實例 I - 229 為實例 I - 195 之 1 對映異構體 (*) 實例 I - 245 為實例 I - 356 之 1 對映異構體 實例I-245：旋光度：-20° (c=1，DCM，25℃)；濃度c以g/100 mL表示。(*) 實例 I - 380 及 I - 392 為實例 I - 606 之 2 對映異構體 (*) 實例 I - 438 及 I - 448 為兩種不同非對映異構體 (*) 實例 I - 091 為 ( S ) 對映異構體且 I - 098 為 ( R ) 對映異構體 (*) 實例 I - 703 及 I - 704 為實例 I - 267 之 2 對映異構體 實例I-703：旋光度：-48.1°(c=0.92，CDCl3，25℃)；濃度c以g/100 mL表示。 實例I-704：旋光度：+40.7°(c=1.08，CDCl3，25℃)；濃度c以g/100 mL表示。(*) 實例 I - 705 及 I - 706 為實例 I - 255 之 2 對映異構體 實例I-705：旋光度：+52.3°(c=1.30，CDCl3, 20℃)；濃度c以g/100 mL表示。 實例I-706：旋光度：-45.5°(c=1.32，CDCl3, 20℃)；濃度c以g/100 mL表示。(*) 實例 I - 721 及 I - 722 為實例 I - 594 之 2 對映異構體 實例I-721：旋光度：+54.4°(c=1, 03，CDCl3，25℃)；濃度c以g/100 mL表示。 實例I-722：旋光度：-50.9°(c=1, 1, CDCl3, 25℃)；濃度c以g/100 mL表示。(*) 實例 I - 723 及 I - 724 為實例 I - 533 之 2 對映異構體 實例I-723：旋光度：+50.7°(c=1.5，CDCl3，25℃)；濃度c以g/100 mL表示。 實例I-724：旋光度：-52.9°(c=1.55，CDCl3，25℃)；濃度c以g/100 mL表示。(*) 實例 I - 725 及 I - 726 為實例 I - 834 之 2 對映異構體 實例I-725：旋光度：+41.9°(c=1.05，CDCl3，25℃)；濃度c以g/100 mL表示。 實例I-726：旋光度：-47°(c=1.15，CDCl3, 25℃)；濃度c以g/100 mL表示。(*) 實例 I - 729 及 I - 730 為實例 I - 407 之 2 對映異構體 實例I-729：旋光度：+48.3°(c=1.45，CDCl3，25℃)；濃度c以g/100 mL表示。 實例I-730：旋光度：-49.7° (c=1.45，CDCl3，25℃)；濃度c以g/100 mL表示。(*) 實例 I - 733 及 I - 734 為實例 I - 367 之 2 對映異構體 實例I-733：旋光度：-57.1°(c=1.16，CDCl3, 20℃)；濃度c以g/100 mL表示。 實例I-734：旋光度：+55.5°(c=1.23, CDCl3, 20℃)；濃度c以g/100 mL表示。(*) 實例 I - 735 及 I - 736 為實例 I - 233 之 2 對映異構體 實例I-735：旋光度：-47.4°(c=1.27，CDCl3, 20℃)；濃度c以g/100 mL表示。 實例I-736：旋光度：+55°(c=1.09，CDCl3, 20℃)；濃度c以g/100 mL表示。(*) 實例 I - 741 及 I-742 為實例 I - 423 之 2 對映異構體 實例I-741：旋光度：+39.8°(c=1.16，CDCl3, 25℃)；濃度c以g/100 mL表示。 實例I-742：旋光度：-38.3°(c=1.10、CDCl3、25℃)；濃度c以g/100 mL表示。(*) 實例 I - 743 及 I - 744 為實例 I - 637 之 2 對映異構體 實例I-743：旋光度：+52.4°(c=0.65，CDCl3, 25℃)；濃度c以g/100 mL表示。 實例I-744：旋光度：-46.7°(c=0.69，CDCl3，25℃)；濃度c以g/100 mL表示。(*) 實例 I - 438 及 I - 448 為兩種不同非對映異構體 (*) 實例 I - 699 及 I - 700 為兩種不同非對映異構體 表2：
I-001:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.8107 (1.9); 8.7970 (3.8); 8.7833 (2.0); 8.3165 (0.4); 8.0884 (16.0); 7.7558 (1.5); 7.7366 (4.8); 7.7171 (5.0); 7.7022 (6.2); 7.6828 (2.5); 7.6550 (7.0); 7.6181 (0.4); 7.5866 (4.1); 7.5661 (3.3); 7.5043 (8.2); 7.4992 (8.6); 7.3845 (6.3); 7.3638 (7.6); 7.3383 (0.5); 7.1510 (4.5); 7.1460 (4.6); 7.1305 (3.9); 7.1254 (3.9); 7.0066 (0.4); 7.0007 (0.4); 3.9025 (2.6); 3.5968 (2.5); 3.5803 (6.9); 3.5649 (7.0); 3.5485 (2.7); 3.5067 (0.5); 3.4896 (0.4); 3.3264 (161.0); 2.9776 (5.0); 2.9609 (9.7); 2.9440 (4.4); 2.9082 (0.6); 2.8930 (0.3); 2.6709 (2.3); 2.5057 (317.3); 2.5019 (387.2); 2.3286 (2.2); 2.2534 (0.3); 1.2979 (0.6); 1.2581 (0.9); 1.2335 (1.1); -0.0007 (1.1)
I-002:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.1785 (5.5); 9.1628 (5.9); 9.1524 (1.4); 9.1319 (2.4); 9.1111 (1.2); 7.8252 (5.7); 7.8096 (5.5); 7.7985 (1.0); 7.7717 (2.8); 7.7458 (3.3); 7.7303 (3.7); 7.7049 (1.3); 7.6786 (4.0); 7.6218 (2.4); 7.5947 (1.7); 7.3465 (3.4); 7.3199 (3.9); 7.1036 (4.4); 6.9516 (2.4); 6.9251 (2.1); 4.1799 (1.2); 4.1595 (1.3); 4.1313 (2.8); 4.1101 (2.7); 4.0972 (0.9); 4.0814 (1.5); 4.0734 (2.0); 4.0609 (1.4); 4.0498 (1.7); 4.0259 (0.6); 3.3599 (89.4); 3.3375 (1.3); 2.5344 (25.6); 2.5285 (18.1); 2.4502 (11.3); 2.2500 (16.0); 2.0219 (6.7); 1.2694 (0.4); 1.2309 (1.8); 1.2072 (3.6); 1.1835 (1.8); 0.0327 (16.7); 0.0217 (0.6)
I-003:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5782 (0.9); 7.5653 (0.8); 7.5336 (2.9); 7.5225 (3.1); 7.5161 (3.2); 7.4008 (1.2); 7.3963 (1.3); 7.3750 (1.7); 7.3706 (1.7); 7.3275 (2.8); 7.3180 (3.4); 7.2986 (11.6); 7.2613 (1.0); 7.2362 (2.4); 7.2104 (2.0); 7.2000 (2.0); 7.1960 (2.1); 7.1754 (0.8); 4.1701 (0.3); 4.1461 (0.3); 3.9709 (1.0); 3.9529 (1.9); 3.9315 (1.8); 3.9132 (1.0); 3.3334 (1.9); 3.3126 (2.2); 3.2932 (1.6); 2.6079 (0.6); 2.4944 (16.0); 2.3772 (15.2); 2.1243 (0.6); 2.0818 (2.3); 1.6144 (1.2); 1.3202 (0.6); 1.2963 (1.3); 1.2727 (0.4); 0.9731 (0.5); 0.1075 (2.8); 0.0377 (13.7)
I-004:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8801 (5.5); 8.7013 (3.9); 8.6934 (3.9); 8.6233 (3.1); 8.6070 (3.2); 8.1063 (1.9); 8.0861 (2.7); 8.0677 (1.9); 8.0072 (2.0); 7.9899 (1.2); 7.7353 (0.7); 7.6895 (7.3); 7.6122 (0.4); 7.5747 (4.3); 7.5410 (2.0); 7.5304 (2.4); 7.5238 (2.3); 7.5117 (2.0); 7.3957 (3.3); 7.3692 (3.7); 7.2987 (7.6); 7.0850 (4.5); 6.9983 (2.5); 6.9715 (2.2); 4.3481 (1.6); 4.3284 (1.6); 4.2999 (3.3); 4.2803 (3.2); 4.2516 (1.8); 4.2321 (1.7); 2.5291 (12.1); 2.3216 (16.0); 1.2928 (0.5); 0.0370 (4.7)
I-005:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2222 (1.6); 9.2020 (1.7); 7.7554 (0.7); 7.7357 (2.0); 7.7160 (1.8); 7.6901 (2.3); 7.6707 (1.1); 7.6394 (2.8); 7.5946 (1.6); 7.5746 (1.2); 7.1221 (3.1); 7.0880 (1.2); 7.0685 (2.1); 7.0314 (3.1); 7.0120 (1.5); 5.1015 (0.9); 5.0830 (1.4); 5.0647 (0.9); 3.3284 (208.8); 2.8981 (1.5); 2.7395 (1.4); 2.5129 (7.1); 2.5088 (9.4); 2.5049 (7.0); 2.3471 (16.0); 2.1837 (0.4); 2.1731 (0.4); 2.1448 (12.8); 2.0469 (13.5); 1.4200 (6.7); 1.4026 (6.6)
I-006:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2946 (11.9); 8.1686 (1.1); 8.1502 (1.5); 8.1300 (0.8); 8.0174 (3.6); 7.9875 (4.0); 7.9689 (1.9); 7.9486 (1.6); 7.9377 (2.1); 7.9260 (0.4); 7.9152 (0.4); 7.9034 (1.8); 7.8931 (1.5); 7.8721 (2.2); 7.6925 (3.9); 7.6849 (4.1); 7.6276 (0.5); 7.6208 (1.0); 7.6046 (3.2); 7.5982 (5.0); 7.5858 (5.4); 7.5732 (4.6); 7.5666 (6.2); 7.5508 (1.1); 7.5374 (4.9); 7.5179 (0.4); 7.5026 (3.9); 7.4991 (3.7); 7.4963 (3.8); 7.3640 (3.1); 7.3560 (3.0); 7.3344 (2.8); 7.3263 (2.7); 7.2985 (18.6); 7.2533 (2.4); 7.2467 (2.4); 7.2251 (2.0); 7.2184 (2.0); 5.3371 (1.7); 4.5118 (2.0); 4.4913 (1.9); 4.4640 (4.1); 4.4435 (4.0); 4.4161 (2.1); 4.3957 (2.0); 4.3629 (1.0); 2.8001 (0.4); 1.5878 (16.0); 1.2953 (3.2); 0.9421 (0.4); 0.9213 (1.0); 0.8976 (0.5); 0.1098 (0.7); 0.0502 (0.7); 0.0394 (17.8); 0.0286 (0.8)
I-007:1 H-NMR(400.0 MHz, CD3CN): δ= 7.9751 (5.5); 7.7515 (0.5); 7.7212 (0.5); 7.7015 (1.4); 7.6819 (2.1); 7.6762 (2.0); 7.6565 (0.5); 7.5619 (1.8); 7.5008 (3.2); 7.4788 (2.9); 7.0353 (1.8); 7.0291 (1.9); 6.7473 (1.1); 6.7410 (1.0); 6.7252 (1.0); 6.7189 (1.0); 4.3426 (1.0); 4.3264 (1.0); 4.3085 (2.2); 4.2922 (2.2); 4.2743 (1.2); 4.2580 (1.1); 3.8729 (0.4); 3.7269 (16.0); 2.1444 (6.0); 2.0923 (0.7); 2.0858 (31.8); 1.9713 (0.6); 1.9636 (0.4); 1.9576 (0.9); 1.9517 (5.1); 1.9455 (9.2); 1.9393 (12.5); 1.9332 (8.5); 1.9270 (4.4)
I-008:1 H-NMR(300.2 MHz, CDCl3): δ= 9.2567 (1.1); 8.5764 (1.2); 8.3948 (16.0); 8.1448 (1.5); 7.9650 (4.9); 7.8949 (3.4); 7.8666 (5.0); 7.7524 (3.8); 7.7467 (3.6); 7.7241 (2.6); 7.7184 (2.6); 7.7001 (2.4); 7.6814 (2.3); 7.6397 (6.9); 7.6223 (8.3); 7.5949 (0.4); 7.5140 (3.9); 7.4790 (0.4); 7.4661 (1.7); 7.4579 (1.7); 7.4539 (1.3); 7.4499 (2.7); 7.4437 (2.2); 7.4360 (1.4); 7.4277 (1.0); 7.2985 (31.8); 5.3366 (14.7); 4.9694 (7.8); 4.9496 (7.8); 2.0815 (1.5); 1.6437 (3.3); 1.3194 (0.3); 1.2954 (1.2); 1.2811 (0.4); 1.2717 (0.4); 0.1072 (1.9); 0.0477 (1.0); 0.0370 (31.9); 0.0260 (1.1)
I-009:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8360 (2.6); 7.8304 (2.6); 7.7772 (2.6); 7.7690 (2.6); 7.5743 (1.3); 7.5592 (1.4); 7.5534 (4.1); 7.5500 (3.5); 7.5369 (0.3); 7.5328 (0.3); 7.4545 (2.4); 7.4404 (1.0); 7.4304 (1.3); 7.4226 (0.7); 7.4164 (0.5); 7.4096 (0.8); 7.4021 (0.4); 7.2988 (2.6); 7.2887 (1.8); 7.2621 (2.0); 7.0324 (2.0); 6.9269 (1.6); 6.9044 (1.6); 6.5727 (1.8); 6.5662 (2.3); 6.5646 (2.3); 6.5581 (1.8); 4.0578 (0.9); 4.0372 (0.8); 4.0091 (1.8); 3.9884 (1.8); 3.9603 (0.9); 3.9396 (0.9); 2.5488 (16.0); 2.4386 (5.9); 2.4317 (3.4); 2.2827 (7.9); 2.0733 (0.5); 1.2953 (0.6); 1.2917 (0.6); 0.1119 (3.8); 0.0384 (2.5)
I-010:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5623 (1.1); 7.5330 (6.1); 7.5038 (6.8); 7.4521 (2.6); 7.4265 (1.6); 7.3961 (6.1); 7.3674 (3.9); 7.3138 (3.2); 7.2986 (9.4); 7.2917 (2.2); 7.2880 (1.7); 7.2683 (1.4); 7.2649 (1.5); 7.2610 (1.3); 7.2573 (1.0); 6.8676 (1.9); 6.6800 (3.9); 6.5430 (0.9); 6.5223 (1.7); 6.5013 (1.0); 6.4924 (2.3); 4.2450 (1.7); 4.2240 (1.6); 4.1978 (3.6); 4.1768 (3.4); 4.1505 (1.9); 4.1296 (1.7); 2.0708 (0.4); 1.6239 (16.0); 1.2896 (0.4); 0.0361 (5.1)
I-011:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9565 (5.8); 8.5241 (4.2); 8.4522 (2.5); 8.4359 (2.7); 8.0462 (0.5); 8.0274 (0.9); 8.0085 (0.5); 7.8990 (2.5); 7.8828 (2.4); 7.6901 (1.7); 7.6709 (4.0); 7.6681 (4.0); 7.5594 (2.2); 7.5301 (1.0); 7.5197 (1.4); 7.5125 (1.2); 7.4997 (1.1); 7.4922 (0.7); 7.3990 (2.1); 7.3724 (2.3); 7.3530 (0.4); 7.2988 (17.8); 7.2437 (0.4); 7.0812 (2.4); 6.9946 (1.2); 6.9685 (1.2); 4.3444 (1.0); 4.3246 (1.0); 4.2962 (2.1); 4.2765 (2.0); 4.2476 (1.2); 4.2282 (1.0); 4.1950 (0.5); 4.1713 (1.4); 4.1475 (1.4); 4.1238 (0.5); 4.0704 (16.0); 4.0473 (0.4); 3.9022 (1.3); 3.7424 (1.7); 2.5285 (6.5); 2.4401 (0.4); 2.3671 (0.8); 2.3196 (9.0); 2.0834 (5.9); 1.6344 (2.1); 1.3210 (1.6); 1.2971 (3.3); 1.2734 (1.5); 0.1076 (0.5); 0.0483 (0.6); 0.0374 (17.9); 0.0270 (0.7)
I-012:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8771 (0.5); 7.8572 (0.8); 7.8382 (0.5); 7.5602 (0.3); 7.5337 (1.2); 7.5081 (3.1); 7.4997 (2.0); 7.4852 (2.4); 7.4485 (1.0); 7.4418 (1.5); 7.4307 (2.0); 7.4176 (0.9); 7.4041 (2.0); 7.2986 (4.5); 7.0877 (2.0); 7.0414 (1.1); 7.0148 (1.0); 4.2639 (0.9); 4.2437 (0.9); 4.2136 (1.8); 4.1934 (1.8); 4.1632 (1.0); 4.1431 (0.9); 3.7400 (1.6); 3.7206 (3.2); 3.7009 (1.9); 3.3673 (16.0); 3.0136 (1.6); 2.9941 (2.8); 2.9747 (1.4); 2.7043 (10.9); 2.5371 (6.0); 2.5306 (3.5); 2.3245 (8.0); 1.6471 (4.6); 1.2938 (0.4); 0.0373 (4.4)
I-013:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9487 (1.9); 7.9534 (0.6); 7.7770 (4.6); 7.7437 (0.5); 7.7244 (1.2); 7.7046 (0.9); 7.6583 (3.3); 7.6390 (0.8); 7.5948 (1.1); 7.5766 (0.7); 7.4720 (0.3); 7.4651 (2.9); 7.4603 (1.2); 7.4485 (1.2); 7.4434 (4.0); 7.4368 (0.6); 7.3188 (0.5); 7.3121 (4.0); 7.3072 (1.3); 7.2953 (1.0); 7.2904 (3.1); 3.3854 (64.3); 2.8927 (3.8); 2.7341 (3.2); 2.6157 (11.7); 2.5161 (4.8); 2.5117 (10.1); 2.5072 (13.6); 2.5027 (10.0); 2.4983 (4.9); 1.6178 (16.0)
I-014:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2582 (10.2); 7.9246 (1.0); 7.9143 (1.7); 7.9040 (1.0); 7.6398 (0.4); 7.6234 (5.3); 7.6131 (7.1); 7.4768 (3.9); 7.4375 (0.4); 7.4294 (1.3); 7.4244 (1.5); 7.4208 (2.1); 7.4170 (2.0); 7.4116 (1.5); 7.4067 (1.1); 7.3188 (3.4); 7.3028 (3.7); 7.2579 (2.0); 7.0344 (4.3); 6.9398 (2.3); 6.9239 (2.1); 4.2397 (1.6); 4.2278 (1.6); 4.2109 (3.5); 4.1990 (3.4); 4.1820 (1.8); 4.1701 (1.7); 2.4664 (11.6); 2.2770 (16.0); 2.0378 (0.4); 1.6111 (1.7); -0.0002 (1.9)
I-015:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5793 (1.3); 7.5585 (3.6); 7.5415 (0.4); 7.5205 (1.9); 7.4916 (3.1); 7.4828 (1.8); 7.4317 (1.6); 7.3729 (0.7); 7.3636 (1.2); 7.3566 (0.8); 7.3418 (0.8); 7.3343 (0.5); 7.2988 (19.8); 7.1607 (1.1); 7.1540 (1.1); 7.1325 (0.9); 7.1258 (0.9); 6.8718 (0.8); 5.3383 (2.7); 4.4303 (0.9); 4.4094 (0.8); 4.3814 (1.8); 4.3607 (1.8); 4.3328 (0.9); 4.3120 (0.9); 3.0174 (0.5); 3.0050 (0.7); 2.9961 (0.7); 2.9835 (0.5); 2.2095 (1.0); 1.5889 (16.0); 1.2927 (0.5); 0.9258 (0.4); 0.9018 (1.8); 0.8847 (1.8); 0.8789 (1.5); 0.8609 (0.6); 0.7222 (0.6); 0.7059 (1.6); 0.6985 (1.8); 0.6935 (1.5); 0.6871 (1.3); 0.6700 (0.4); 0.0484 (0.7); 0.0376 (17.6); 0.0267 (0.7)
I-016:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0869 (4.1); 8.0261 (0.4); 7.6498 (0.9); 7.6290 (2.6); 7.5165 (1.2); 7.4622 (1.6); 7.4544 (0.9); 7.4472 (0.6); 7.4332 (3.3); 7.4266 (1.4); 7.2993 (37.6); 7.2667 (1.1); 7.2597 (1.0); 7.2389 (0.8); 7.2325 (0.9); 6.1332 (0.3); 6.1206 (0.3); 5.9776 (0.3); 5.9651 (0.3); 5.9542 (0.3); 3.8371 (0.4); 3.8207 (0.4); 2.2766 (0.4); 2.2692 (0.4); 2.2513 (0.8); 2.2344 (0.4); 2.2250 (0.4); 1.5765 (16.0); 1.2018 (1.8); 1.1878 (2.9); 1.1801 (1.5); 1.1674 (1.0); 1.1618 (1.7); 1.1531 (0.7); 0.0499 (1.3); 0.0391 (38.4); 0.0298 (1.2); 0.0282 (1.4)
I-017:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.7978 (2.0); 7.9527 (0.4); 7.7595 (4.7); 7.7406 (0.5); 7.7207 (1.3); 7.7014 (1.0); 7.6571 (2.7); 7.6353 (0.8); 7.5965 (1.0); 7.5773 (0.7); 7.3678 (0.3); 7.3599 (3.2); 7.3549 (1.2); 7.3431 (1.0); 7.3378 (3.6); 7.3300 (0.4); 6.8176 (0.4); 6.8097 (3.6); 6.8047 (1.2); 6.7928 (1.0); 6.7876 (3.4); 6.7797 (0.4); 3.7090 (15.5); 3.3521 (25.3); 3.3487 (26.5); 3.3469 (27.0); 2.8904 (3.0); 2.7319 (2.7); 2.6114 (12.0); 2.5123 (5.9); 2.5079 (12.4); 2.5034 (16.9); 2.4988 (12.2); 2.4943 (5.9); 1.6151 (16.0); -0.0002 (0.4)
I-018:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0625 (0.8); 9.0469 (1.6); 9.0310 (0.7); 8.3102 (0.8); 7.7362 (0.7); 7.7165 (1.9); 7.6968 (1.6); 7.6683 (2.1); 7.6584 (6.4); 7.6488 (1.1); 7.5756 (2.5); 7.5299 (1.4); 7.5099 (1.1); 7.4879 (2.4); 7.4675 (2.6); 7.3753 (3.0); 7.0568 (1.5); 7.0360 (1.4); 4.2668 (0.7); 4.2511 (0.7); 4.2314 (1.5); 4.2158 (1.4); 4.1959 (0.8); 4.1801 (0.7); 3.3251 (248.3); 2.7115 (0.4); 2.6759 (0.8); 2.6714 (1.1); 2.6670 (0.8); 2.5779 (16.0); 2.5418 (85.8); 2.5110 (68.8); 2.5069 (131.0); 2.5024 (169.1); 2.4979 (126.4); 2.4937 (64.7); 2.4534 (0.8); 2.4455 (0.9); 2.4247 (0.5); 2.4175 (0.5); 2.3678 (0.4); 2.3337 (0.8); 2.3293 (1.1); 2.3247 (0.8); 1.7637 (1.0); 1.7560 (1.1); 1.7358 (1.6); 1.6948 (0.9); 1.6663 (2.3); 1.3301 (0.9); 1.3015 (2.5); 1.2802 (3.1); 1.2578 (1.2); 1.2533 (1.2); 1.2240 (0.6); 1.2013 (0.5); 1.1939 (0.5); 1.1779 (0.3); 1.1708 (0.4); -0.0003 (1.5)
I-019:1 H-NMR(400.0 MHz, CD3CN): δ= 8.0424 (16.0); 7.9978 (0.5); 7.8328 (1.1); 7.7418 (1.0); 7.7223 (3.5); 7.7036 (6.9); 7.6801 (1.1); 7.5698 (4.7); 7.5201 (1.8); 7.5155 (3.1); 7.5107 (1.8); 7.4970 (2.3); 7.2210 (0.4); 7.1857 (11.3); 7.0864 (4.8); 5.4757 (0.6); 4.6765 (0.3); 4.1884 (2.9); 4.1724 (2.8); 4.1534 (6.2); 4.1374 (6.0); 4.1183 (3.1); 4.1023 (3.0); 2.4224 (0.4); 2.3762 (0.9); 2.3604 (2.0); 2.3046 (0.6); 2.2660 (57.6); 2.2493 (173.0); 2.2456 (113.2); 2.2432 (158.1); 2.2370 (239.3); 2.1370 (0.4); 1.9939 (1.7); 1.9878 (3.8); 1.9819 (22.5); 1.9758 (41.1); 1.9696 (55.7); 1.9634 (38.2); 1.9573 (19.6); 1.7981 (0.3); 1.4568 (0.3); 1.4392 (0.7); 1.4215 (0.3)
I-020:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6131 (0.4); 7.5837 (4.0); 7.5784 (3.0); 7.5696 (6.7); 7.5663 (8.1); 7.5518 (0.6); 7.4740 (3.5); 7.4537 (0.6); 7.4402 (1.6); 7.4313 (1.4); 7.4263 (2.3); 7.4157 (4.4); 7.4017 (1.1); 7.3891 (4.1); 7.2986 (23.3); 7.0821 (4.0); 6.9966 (2.1); 6.9695 (1.9); 6.3355 (0.9); 6.3155 (1.7); 6.2946 (0.9); 4.3078 (2.0); 4.2872 (2.0); 4.2592 (4.3); 4.2386 (4.1); 4.2105 (2.2); 4.1900 (2.1); 2.5270 (12.0); 2.5199 (6.8); 2.3578 (0.4); 2.3437 (0.4); 2.3079 (16.0); 2.0786 (0.8); 1.6230 (1.2); 1.5909 (10.0); 1.2951 (0.8); 0.1084 (2.2); 0.0492 (0.8); 0.0385 (23.7); 0.0276 (0.8)
I-021:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2042 (6.1); 8.3131 (16.0); 8.3103 (15.3); 7.8559 (12.6); 7.7956 (2.0); 7.7763 (6.4); 7.7567 (7.4); 7.7441 (10.8); 7.7260 (4.5); 7.6973 (11.1); 7.6138 (6.3); 7.5954 (5.7); 7.5056 (6.2); 7.4848 (9.2); 7.3778 (7.6); 7.3570 (6.1); 4.3250 (2.8); 4.3127 (3.4); 4.2920 (6.2); 4.2785 (6.6); 4.2580 (3.7); 4.2440 (3.4); 3.3014 (21.7); 3.2987 (20.8); 2.5385 (0.4); 2.5006 (30.8); 2.4973 (32.4); 2.0722 (4.1); 2.0691 (3.8); -0.0002 (7.3); -0.0034 (6.7)
I-022:1 H-NMR(300.2 MHz, CDCl3): δ= 8.6534 (4.2); 8.6386 (2.5); 8.6217 (2.4); 8.4961 (8.9); 8.0835 (0.7); 8.0643 (1.2); 8.0445 (0.7); 7.7306 (0.4); 7.7038 (2.1); 7.6846 (5.5); 7.6814 (5.1); 7.5833 (2.6); 7.5695 (0.5); 7.5534 (1.2); 7.5430 (1.6); 7.5356 (1.4); 7.5229 (1.1); 7.5149 (0.6); 7.4538 (2.8); 7.4370 (2.7); 7.3989 (2.5); 7.3722 (2.8); 7.2985 (15.8); 7.0857 (2.8); 7.0013 (1.6); 6.9747 (1.4); 4.3441 (1.3); 4.3244 (1.3); 4.2958 (2.7); 4.2761 (2.6); 4.2474 (1.4); 4.2278 (1.3); 2.5275 (8.4); 2.5204 (4.8); 2.4699 (16.0); 2.3240 (11.4); 2.0832 (0.9); 1.2966 (1.1); 0.1077 (0.6); 0.0478 (0.6); 0.0371 (16.1); 0.0262 (0.6)
I-023:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.3497 (3.0); 9.3299 (3.0); 8.2081 (16.0); 7.9533 (0.5); 7.8882 (6.0); 7.8757 (2.7); 7.8710 (3.0); 7.8606 (5.7); 7.8533 (3.5); 7.8396 (5.3); 7.7540 (5.4); 7.7473 (4.8); 7.7258 (4.1); 7.7092 (4.6); 7.6877 (3.9); 7.6639 (5.3); 7.6409 (2.1); 7.5805 (3.5); 7.5764 (3.5); 7.5592 (3.1); 7.5551 (3.1); 7.4844 (0.9); 7.4805 (1.3); 7.4674 (3.3); 7.4633 (3.0); 7.4556 (3.4); 7.4498 (6.6); 7.4439 (3.2); 7.4363 (2.8); 7.4323 (3.0); 7.4191 (1.1); 7.4152 (0.8); 5.3414 (0.4); 5.3235 (1.8); 5.3054 (2.6); 5.2871 (1.8); 5.2689 (0.4); 3.3520 (164.4); 2.8902 (3.0); 2.7324 (2.8); 2.5264 (0.8); 2.5128 (19.0); 2.5086 (39.4); 2.5042 (52.6); 2.4998 (38.1); 2.4955 (18.5); 1.5598 (13.0); 1.5423 (12.9); 1.2383 (1.3); -0.0002 (3.6)
I-024:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0867 (12.1); 8.0259 (1.5); 7.6755 (0.6); 7.6493 (3.0); 7.6289 (8.0); 7.6262 (7.3); 7.5168 (3.9); 7.4810 (0.4); 7.4744 (0.5); 7.4619 (5.1); 7.4548 (3.2); 7.4472 (2.2); 7.4329 (10.7); 7.2997 (38.6); 7.2666 (3.2); 7.2599 (3.2); 7.2387 (2.3); 7.2322 (2.6); 6.1438 (1.0); 6.1331 (1.1); 6.1204 (1.0); 6.1102 (1.0); 5.9880 (1.0); 5.9776 (1.1); 5.9646 (1.1); 5.9539 (1.0); 5.3390 (15.6); 4.3556 (0.6); 4.3452 (0.6); 4.3335 (0.6); 4.3225 (0.6); 4.3068 (0.7); 4.2959 (0.7); 4.2850 (0.7); 4.2737 (0.7); 4.2662 (0.6); 4.2552 (0.6); 4.2436 (0.6); 4.2321 (0.6); 4.2171 (0.7); 4.2063 (0.7); 4.1947 (0.8); 4.1837 (0.7); 3.9091 (0.7); 3.8915 (0.7); 3.8852 (0.8); 3.8679 (0.7); 3.8605 (0.7); 3.8377 (1.3); 3.8204 (1.2); 3.7975 (0.7); 3.7896 (0.7); 3.7723 (0.6); 3.7662 (0.6); 3.7489 (0.6); 2.2949 (0.6); 2.2767 (1.0); 2.2690 (1.3); 2.2608 (0.9); 2.2515 (2.6); 2.2405 (1.0); 2.2339 (1.2); 2.2253 (1.3); 2.2078 (0.7); 1.5813 (16.0); 1.2952 (0.9); 1.2016 (6.1); 1.1926 (6.8); 1.1877 (9.5); 1.1805 (5.6); 1.1675 (3.4); 1.1618 (5.5); 1.1534 (2.6); 1.1304 (0.5); 0.9210 (0.4); 0.0496 (1.6); 0.0392 (40.5)
I-025:1 H-NMR(300.2 MHz, CDCl3): δ= 9.3970 (4.0); 9.0571 (16.0); 8.1441 (1.6); 8.1248 (2.8); 8.1055 (1.6); 7.6311 (1.1); 7.6048 (5.2); 7.5943 (4.4); 7.5850 (13.5); 7.5817 (12.0); 7.5688 (1.2); 7.5647 (1.2); 7.4700 (7.4); 7.4407 (15.6); 7.3789 (13.4); 7.3635 (5.4); 7.3501 (8.5); 7.3355 (2.2); 7.2991 (4.6); 4.1637 (3.5); 4.1435 (3.4); 4.1170 (7.4); 4.0968 (7.2); 4.0703 (3.7); 4.0501 (3.6); 2.6976 (0.6); 2.6853 (1.3); 2.6748 (1.9); 2.6629 (2.7); 2.6557 (2.7); 2.6435 (2.0); 2.6332 (1.4); 2.6209 (0.6); 1.7644 (1.4); 1.2926 (1.0); 1.0176 (1.9); 0.9989 (5.8); 0.9944 (7.4); 0.9769 (7.7); 0.9716 (6.0); 0.9543 (2.4); 0.9236 (0.4); 0.9012 (0.4); 0.7781 (0.3); 0.7371 (2.6); 0.7235 (5.8); 0.7205 (6.3); 0.7137 (7.1); 0.7083 (6.4); 0.7026 (6.0); 0.6849 (1.9); 0.0347 (3.8)
I-026:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9018 (1.9); 7.9533 (0.4); 7.7774 (4.6); 7.7415 (0.5); 7.7215 (1.2); 7.7026 (0.9); 7.6561 (3.2); 7.6364 (0.8); 7.5951 (1.0); 7.5771 (0.7); 7.4828 (1.5); 7.4775 (0.7); 7.4692 (1.7); 7.4605 (1.9); 7.4523 (0.8); 7.4470 (1.7); 7.0841 (1.8); 7.0789 (0.6); 7.0619 (3.4); 7.0449 (0.5); 7.0396 (1.6); 3.3573 (18.7); 3.3511 (29.1); 3.3478 (29.2); 2.8914 (2.8); 2.7325 (2.6); 2.6144 (11.4); 2.5133 (5.9); 2.5089 (12.4); 2.5044 (16.6); 2.4998 (12.0); 2.4954 (5.8); 1.6263 (16.0); -0.0002 (0.3)
I-027:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5950 (0.4); 7.5690 (1.5); 7.5457 (4.3); 7.5272 (0.5); 7.5222 (0.5); 7.4363 (2.1); 7.3796 (0.9); 7.3713 (1.5); 7.3639 (1.1); 7.3558 (3.3); 7.3488 (3.8); 7.2983 (8.4); 7.2454 (2.2); 7.2180 (3.0); 7.0767 (1.9); 7.0697 (1.8); 7.0494 (1.4); 7.0424 (1.3); 6.1817 (0.5); 6.1624 (0.9); 6.1436 (0.5); 4.1651 (0.7); 4.1413 (0.7); 3.8674 (1.1); 3.8456 (3.0); 3.8243 (3.1); 3.8023 (1.2); 3.1281 (2.1); 3.1057 (4.1); 3.0833 (1.9); 2.6461 (0.6); 2.6388 (0.4); 2.6190 (16.0); 2.3269 (15.9); 2.2242 (0.4); 2.0776 (3.1); 1.6132 (8.2); 1.3177 (1.1); 1.2939 (2.5); 1.2701 (0.9); 0.9183 (0.7); 0.0469 (0.4); 0.0362 (8.5)
I-028:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0621 (0.6); 9.0464 (1.4); 9.0307 (0.6); 8.3094 (1.4); 7.7381 (0.6); 7.7181 (1.8); 7.6982 (1.5); 7.6712 (1.8); 7.6570 (6.7); 7.5842 (2.2); 7.5252 (1.2); 7.5045 (1.0); 7.4895 (2.4); 7.4691 (2.6); 7.3587 (2.6); 7.0405 (1.3); 7.0202 (1.2); 4.2688 (0.6); 4.2533 (0.6); 4.2335 (1.4); 4.2176 (1.4); 4.1981 (0.7); 4.1822 (0.7); 3.4810 (0.5); 3.4588 (0.8); 3.4369 (0.7); 3.3231 (377.2); 2.7115 (0.4); 2.6804 (0.6); 2.6759 (1.2); 2.6714 (1.7); 2.6668 (1.2); 2.6623 (0.6); 2.5993 (0.4); 2.5794 (16.0); 2.5415 (104.8); 2.5248 (5.2); 2.5199 (7.6); 2.5114 (103.4); 2.5069 (205.2); 2.5024 (267.4); 2.4978 (193.5); 2.4933 (94.2); 2.3681 (0.4); 2.3382 (0.6); 2.3338 (1.2); 2.3292 (1.7); 2.3247 (1.2); 2.3202 (0.6); 2.2952 (0.4); 2.2643 (0.4); 2.2568 (0.4); 2.2453 (1.0); 2.2380 (1.3); 2.2301 (1.0); 2.2185 (1.6); 2.2110 (1.0); 2.1996 (0.5); 2.0123 (0.6); 2.0078 (0.8); 2.0020 (0.6); 1.9825 (1.6); 1.9719 (1.8); 1.9630 (2.0); 1.9554 (1.6); 1.9410 (0.3); 1.9337 (0.6); 1.9255 (0.4); 1.7921 (0.4); 1.7762 (1.0); 1.7627 (0.5); 1.7592 (0.5); 1.7498 (0.4); -0.0003 (3.0)
I-029:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3638 (3.1); 7.3569 (3.1); 7.3491 (1.6); 7.3225 (2.8); 7.2983 (9.6); 7.2181 (2.3); 7.1907 (2.9); 7.0295 (2.3); 7.0223 (3.1); 7.0022 (2.0); 6.9952 (2.8); 6.9391 (1.4); 6.9339 (1.6); 6.9119 (1.3); 6.9071 (1.4); 6.8625 (2.2); 6.8571 (2.7); 6.2724 (1.2); 6.2521 (0.7); 3.8363 (1.2); 3.8148 (3.2); 3.7933 (3.2); 3.7718 (1.2); 3.0968 (2.3); 3.0747 (4.2); 3.0525 (2.0); 2.4151 (16.0); 2.3069 (0.4); 1.9783 (0.3); 1.9610 (0.7); 1.9499 (0.8); 1.9335 (1.3); 1.9167 (0.8); 1.9059 (0.8); 1.8894 (0.4); 1.5964 (7.1); 1.3044 (1.3); 1.0457 (0.9); 1.0301 (2.4); 1.0237 (2.6); 1.0084 (1.7); 1.0019 (2.6); 0.9959 (2.3); 0.9809 (1.1); 0.9412 (0.5); 0.9197 (1.1); 0.8969 (0.5); 0.7565 (1.1); 0.7410 (3.2); 0.7360 (2.9); 0.7248 (2.8); 0.7194 (3.0); 0.7030 (0.8); 0.1075 (0.8); 0.0376 (8.2)
I-030:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3152 (10.5); 7.9723 (1.1); 7.6904 (4.2); 7.6729 (5.9); 7.5352 (3.2); 7.5273 (4.0); 7.4980 (6.7); 7.4751 (1.2); 7.4660 (1.2); 7.4597 (1.9); 7.4527 (2.5); 7.4450 (7.4); 7.4167 (3.0); 7.3046 (36.3); 5.3440 (1.2); 4.2784 (1.7); 4.2582 (1.7); 4.2306 (3.7); 4.2104 (3.6); 4.2005 (0.8); 4.1827 (1.9); 4.1768 (2.0); 4.1626 (1.8); 4.1530 (1.9); 4.1292 (0.8); 4.1079 (0.6); 2.0895 (9.9); 2.0521 (0.7); 1.6060 (16.0); 1.3266 (2.3); 1.3028 (4.8); 1.2790 (2.2); 1.0031 (0.4); 0.9785 (0.9); 0.9540 (0.4); 0.1123 (1.9); 0.0533 (1.0); 0.0426 (31.1); 0.0317 (1.1)
I-031:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.3389 (0.5); 9.2040 (0.9); 8.1063 (1.6); 7.9541 (2.4); 7.8653 (2.1); 7.7723 (0.9); 7.6898 (0.6); 7.6707 (1.1); 7.6339 (0.6); 7.6142 (0.3); 7.6003 (0.5); 4.6871 (1.1); 4.6728 (1.1); 3.3281 (12.0); 2.8936 (16.0); 2.7348 (14.0); 2.6160 (5.5); 2.5134 (4.8); 2.5090 (10.0); 2.5046 (13.3); 2.5000 (9.5); 2.4957 (4.6); -0.0002 (2.2)
I-032:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9417 (4.5); 8.8312 (4.0); 8.8227 (4.1); 8.3484 (14.0); 7.9412 (2.6); 7.9347 (4.2); 7.9283 (2.6); 7.8152 (1.5); 7.4743 (4.2); 7.4619 (3.6); 7.4568 (4.9); 7.4507 (4.7); 7.4467 (6.3); 7.3268 (3.9); 7.3204 (3.6); 7.2998 (42.8); 7.2936 (3.7); 6.1401 (1.1); 6.1299 (1.1); 6.1146 (1.2); 6.1043 (1.1); 5.9835 (1.1); 5.9734 (1.2); 5.9586 (1.2); 5.9479 (1.1); 5.3388 (0.4); 4.3915 (0.7); 4.3812 (0.8); 4.3686 (0.6); 4.3579 (0.7); 4.3426 (0.8); 4.3324 (0.9); 4.3194 (0.8); 4.3091 (0.8); 4.2959 (0.6); 4.2856 (0.7); 4.2728 (0.7); 4.2625 (0.7); 4.2472 (0.8); 4.2367 (0.8); 4.2240 (0.9); 4.2136 (0.8); 4.1958 (0.6); 4.1719 (1.5); 4.1481 (1.5); 4.1245 (0.8); 4.1034 (0.5); 3.8755 (0.9); 3.8590 (0.9); 3.8504 (0.8); 3.8335 (0.8); 3.8268 (0.7); 3.8100 (1.4); 3.8013 (0.8); 3.7932 (1.0); 3.7847 (1.4); 3.7678 (0.8); 3.7611 (0.8); 3.7447 (0.7); 3.7353 (0.6); 3.7190 (0.6); 2.0835 (8.4); 1.5900 (16.0); 1.3218 (2.1); 1.2979 (5.2); 1.2742 (2.1); 0.9985 (0.4); 0.9741 (0.9); 0.9498 (0.4); 0.0494 (1.3); 0.0386 (41.6); 0.0278 (1.9)
I-033:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3143 (2.0); 7.6810 (0.8); 7.6636 (1.4); 7.6449 (0.4); 7.6169 (1.0); 7.5904 (7.6); 7.5814 (6.7); 7.5731 (15.0); 7.5700 (16.0); 7.5368 (0.8); 7.4966 (7.7); 7.4849 (8.6); 7.4566 (12.2); 7.4471 (7.8); 7.4414 (12.0); 7.4368 (9.4); 7.4284 (5.8); 7.4216 (4.3); 7.4110 (3.0); 7.4026 (2.1); 7.3675 (0.6); 7.3606 (0.6); 7.2988 (20.5); 7.2853 (6.5); 7.2786 (6.2); 7.2575 (4.9); 7.2507 (4.9); 7.2357 (0.5); 6.5053 (1.9); 6.4844 (2.9); 6.4660 (1.9); 6.1322 (2.0); 6.1228 (2.3); 6.1070 (2.2); 6.0978 (2.1); 5.9762 (2.0); 5.9668 (2.2); 5.9510 (2.2); 5.9418 (2.0); 5.3365 (0.8); 4.4254 (0.3); 4.3617 (1.0); 4.3523 (1.1); 4.3382 (1.1); 4.3286 (1.1); 4.3127 (1.2); 4.3032 (1.3); 4.2891 (1.2); 4.2795 (1.3); 4.2648 (1.2); 4.2553 (1.1); 4.2412 (1.2); 4.2315 (1.1); 4.2159 (1.5); 4.2062 (1.3); 4.1923 (1.4); 4.1826 (1.3); 3.8415 (1.3); 3.8243 (1.6); 3.8163 (1.4); 3.7989 (1.4); 3.7926 (1.2); 3.7733 (1.9); 3.7675 (1.4); 3.7551 (1.7); 3.7491 (1.9); 3.7342 (1.7); 3.7301 (1.4); 3.7235 (1.2); 3.7062 (1.1); 3.6983 (1.0); 3.6810 (1.0); 3.1304 (0.5); 1.6209 (11.5); 1.4378 (0.5); 1.3350 (0.5); 1.2913 (4.6); 0.9392 (0.4); 0.9178 (1.0); 0.8931 (0.6); 0.1076 (3.6); 0.0470 (0.5); 0.0362 (18.4); 0.0254 (0.8)
I-034:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0740 (2.0); 7.9542 (0.8); 7.7629 (5.4); 7.7516 (2.4); 7.7231 (1.4); 7.7033 (1.1); 7.6646 (1.4); 7.6411 (1.6); 7.6356 (1.8); 7.5897 (1.0); 7.5643 (1.0); 7.5435 (1.8); 7.5375 (1.8); 7.5259 (0.4); 7.5169 (1.2); 7.4973 (0.4); 3.3567 (14.3); 3.3505 (18.1); 3.3486 (17.9); 3.3446 (17.9); 2.8913 (5.6); 2.7330 (5.1); 2.6098 (11.5); 2.5133 (5.8); 2.5090 (12.2); 2.5045 (16.3); 2.5000 (11.7); 2.4955 (5.7); 1.6740 (16.0); -0.0002 (0.5)
I-035:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0689 (0.6); 9.0535 (1.4); 9.0379 (0.7); 8.3101 (0.8); 7.7355 (0.6); 7.7158 (1.8); 7.6960 (1.5); 7.6676 (1.9); 7.6575 (6.4); 7.6484 (1.0); 7.5862 (2.2); 7.5315 (1.2); 7.5109 (1.0); 7.4811 (2.4); 7.4607 (2.6); 7.3975 (2.7); 7.0775 (1.4); 7.0596 (1.2); 7.0569 (1.2); 4.2676 (0.6); 4.2523 (0.6); 4.2326 (1.4); 4.2169 (1.4); 4.1973 (0.7); 4.1813 (0.7); 3.3237 (218.0); 2.9392 (0.5); 2.9338 (0.5); 2.9147 (1.0); 2.8955 (0.6); 2.8906 (0.6); 2.6803 (0.3); 2.6759 (0.7); 2.6714 (1.0); 2.6669 (0.7); 2.6623 (0.4); 2.5797 (16.0); 2.5417 (84.6); 2.5248 (3.0); 2.5200 (4.6); 2.5114 (60.0); 2.5069 (120.0); 2.5024 (158.2); 2.4978 (116.8); 2.4934 (58.3); 2.3680 (0.4); 2.3381 (0.4); 2.3338 (0.8); 2.3292 (1.0); 2.3246 (0.8); 2.3205 (0.4); 1.9799 (0.4); 1.9752 (0.4); 1.9614 (0.8); 1.9513 (0.9); 1.9478 (0.9); 1.9360 (1.0); 1.9328 (1.0); 1.9260 (0.9); 1.9125 (0.5); 1.9067 (0.5); 1.7438 (0.7); 1.7342 (1.1); 1.7227 (1.5); 1.7136 (1.0); 1.7067 (0.9); 1.6907 (0.5); 1.6816 (0.4); 1.6578 (0.4); 1.6512 (0.4); 1.6382 (0.6); 1.6300 (0.9); 1.6182 (1.2); 1.6107 (1.3); 1.5984 (1.3); 1.5919 (0.6); 1.5883 (0.6); 1.5832 (0.4); 1.4498 (0.4); 1.4302 (0.8); 1.4211 (0.8); 1.4136 (0.7); 1.4058 (1.0); 1.4003 (0.9); 1.3914 (0.7); 1.3850 (0.6); 1.3805 (0.6); 1.3756 (0.7); 0.2083 (0.4); -0.0002 (1.6)
I-036:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.7437 (0.5); 8.7295 (1.0); 8.7156 (0.5); 8.0812 (6.9); 7.7605 (0.4); 7.7410 (1.3); 7.7208 (1.4); 7.7058 (1.7); 7.6937 (2.1); 7.6050 (1.1); 7.5851 (0.8); 7.1609 (2.9); 7.1395 (3.3); 6.7362 (0.4); 6.7289 (3.5); 6.7075 (3.2); 3.9028 (0.4); 3.6412 (16.0); 3.5171 (0.7); 3.5000 (1.8); 3.4851 (1.8); 3.4680 (0.8); 3.3261 (56.4); 2.7831 (1.3); 2.7657 (2.7); 2.7482 (1.2); 2.6754 (0.4); 2.6709 (0.6); 2.6663 (0.4); 2.5242 (2.0); 2.5106 (38.1); 2.5064 (76.0); 2.5020 (98.7); 2.4974 (71.9); 2.4932 (35.9); 2.3331 (0.4); 2.3288 (0.6); 2.3242 (0.4); -0.0002 (0.4)
I-037:1 H-NMR(400.0 MHz, CD3CN): δ= 8.4807 (4.0); 8.4688 (4.1); 8.2534 (1.5); 8.1058 (16.0); 8.0164 (0.8); 7.9419 (4.1); 7.9219 (4.4); 7.7029 (1.3); 7.6828 (4.9); 7.6650 (13.1); 7.6468 (1.3); 7.5737 (0.4); 7.4931 (6.8); 7.4724 (2.6); 7.4668 (4.2); 7.4618 (2.3); 7.4495 (3.1); 7.3192 (0.4); 7.2593 (2.8); 7.2469 (2.9); 7.2396 (2.9); 7.2273 (2.6); 7.0640 (0.4); 4.1542 (0.4); 4.1382 (0.4); 3.9479 (3.7); 3.9325 (10.4); 3.9170 (10.7); 3.9015 (4.0); 3.2741 (4.8); 3.2584 (8.8); 3.2427 (4.4); 2.4427 (1.0); 2.2297 (1.5); 2.1284 (29.5); 2.1136 (0.6); 2.1064 (0.6); 2.1004 (0.4); 1.9632 (2.5); 1.9570 (6.5); 1.9514 (33.7); 1.9453 (60.9); 1.9392 (81.9); 1.9330 (56.6); 1.9269 (29.5); 1.7736 (0.4); 1.7676 (0.5); 1.7613 (0.3); 1.2851 (0.4); 1.2700 (0.8); 0.1460 (0.9); 0.0077 (7.1); -0.0002 (174.4); -0.1492 (0.9)
I-038:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1500 (2.9); 8.3549 (16.0); 7.7930 (1.2); 7.7735 (4.1); 7.7540 (4.8); 7.7439 (5.5); 7.7241 (1.8); 7.7003 (5.9); 7.6260 (3.5); 7.6066 (2.7); 7.5867 (7.7); 7.5653 (9.9); 7.4181 (9.4); 7.3969 (7.6); 4.1915 (1.4); 4.1778 (1.5); 4.1570 (3.0); 4.1434 (3.0); 4.1223 (1.6); 4.1089 (1.5); 3.3024 (42.7); 2.5052 (14.7); 2.5008 (20.0); 2.4964 (15.0); 2.0719 (0.6); -0.0002 (7.2)
I-039:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6217 (0.6); 7.5950 (4.6); 7.5912 (4.3); 7.5860 (3.8); 7.5778 (9.3); 7.5746 (9.7); 7.5255 (6.1); 7.4968 (9.2); 7.4476 (4.6); 7.4103 (0.9); 7.3899 (10.2); 7.3771 (3.4); 7.3619 (6.5); 7.2986 (17.0); 6.3031 (1.2); 6.2826 (2.3); 6.2623 (1.2); 4.2568 (2.5); 4.2360 (2.4); 4.2091 (5.3); 4.1883 (5.0); 4.1614 (2.7); 4.1406 (2.5); 2.8691 (6.3); 2.8631 (15.8); 2.8566 (16.0); 2.8503 (6.2); 1.6006 (12.4); 1.3191 (0.4); 1.2929 (2.2); 1.2654 (0.3); 0.9190 (0.6); 0.8952 (0.3); 0.1078 (4.0); 0.0478 (0.6); 0.0371 (15.7); 0.0261 (0.6)
I-040:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1644 (0.5); 8.1445 (0.9); 8.1246 (0.5); 7.6145 (2.0); 7.5861 (2.5); 7.5689 (1.3); 7.5453 (3.9); 7.5146 (2.0); 7.5084 (2.1); 7.4867 (1.8); 7.4348 (0.8); 7.4270 (1.4); 7.4197 (0.8); 7.4135 (0.5); 7.4106 (0.5); 7.4045 (0.9); 7.3972 (0.6); 7.3145 (1.3); 7.3079 (1.2); 7.2986 (2.2); 7.2863 (1.1); 7.2797 (1.0); 5.3317 (0.8); 4.4173 (0.9); 4.3967 (0.8); 4.3674 (1.9); 4.3468 (1.8); 4.3175 (1.0); 4.2970 (0.9); 4.1197 (0.7); 3.8547 (1.6); 3.8362 (2.9); 3.8170 (1.8); 3.4061 (16.0); 3.3505 (0.5); 3.1150 (1.8); 3.0959 (2.8); 3.0773 (1.6); 2.2005 (0.9); 1.2910 (0.5); 0.0342 (1.6)
I-041:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5857 (0.6); 7.5565 (4.0); 7.5357 (5.9); 7.5279 (5.1); 7.4596 (2.3); 7.4268 (4.3); 7.3995 (3.9); 7.3780 (1.1); 7.2988 (16.8); 6.3858 (0.5); 6.3659 (0.9); 6.3463 (0.5); 5.3371 (10.2); 4.2732 (1.1); 4.2521 (1.1); 4.2253 (2.3); 4.2041 (2.2); 4.1773 (1.3); 4.1673 (0.4); 4.1561 (1.2); 4.1433 (0.3); 3.7328 (0.4); 3.7204 (0.4); 3.7081 (0.3); 3.6979 (0.4); 3.6925 (0.4); 2.6852 (16.0); 2.6552 (1.0); 2.6299 (3.0); 2.6046 (3.1); 2.5796 (1.0); 2.2052 (0.9); 2.0798 (0.9); 1.6100 (4.7); 1.3375 (0.4); 1.3190 (0.7); 1.2931 (4.2); 1.2713 (0.9); 1.2555 (3.8); 1.2305 (7.8); 1.2052 (3.6); 1.1809 (0.4); 0.9176 (0.6); 0.8934 (0.5); 0.8676 (0.4); 0.1073 (6.9); 0.0950 (0.3); 0.0481 (0.4); 0.0373 (11.5); 0.0265 (0.5)
I-042:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9406 (4.7); 8.8296 (4.3); 8.8211 (4.4); 8.3176 (16.0); 7.9490 (2.8); 7.9426 (4.5); 7.9361 (2.7); 7.8142 (1.0); 7.7948 (1.7); 7.7768 (1.0); 7.6043 (5.1); 7.5759 (6.3); 7.5401 (4.4); 7.5338 (4.5); 7.3595 (3.2); 7.3528 (3.0); 7.3312 (2.6); 7.3246 (2.5); 7.2995 (26.4); 5.3379 (0.7); 4.4987 (2.6); 4.4783 (2.5); 4.4494 (5.5); 4.4289 (5.3); 4.4000 (2.8); 4.3796 (2.7); 4.1941 (0.3); 4.1703 (1.0); 4.1464 (1.0); 4.1229 (0.4); 2.0821 (4.8); 2.0442 (0.9); 1.5965 (13.8); 1.3207 (1.3); 1.2968 (3.0); 1.2731 (1.2); 0.0488 (0.8); 0.0378 (25.6); 0.0268 (0.9)
I-043:1 H-NMR(300.2 MHz, CDCl3): δ= 9.4794 (2.2); 9.0627 (6.0); 8.1365 (0.8); 8.1196 (1.5); 8.1008 (0.9); 7.6262 (0.5); 7.5999 (2.8); 7.5805 (7.6); 7.5774 (6.7); 7.5653 (0.7); 7.5606 (0.6); 7.4185 (3.7); 7.3941 (1.5); 7.3835 (2.2); 7.3763 (1.7); 7.3719 (1.1); 7.3633 (1.6); 7.3559 (1.0); 7.3297 (3.5); 7.2987 (10.6); 7.0402 (3.9); 6.9391 (2.1); 6.9125 (1.9); 4.2072 (1.9); 4.1877 (1.9); 4.1711 (0.4); 4.1595 (4.1); 4.1399 (4.0); 4.1117 (2.1); 4.0922 (2.0); 2.7019 (0.3); 2.6896 (0.7); 2.6790 (1.0); 2.6671 (1.5); 2.6599 (1.5); 2.6478 (1.1); 2.6376 (0.7); 2.6255 (0.3); 2.4905 (6.4); 2.4838 (11.6); 2.4765 (6.6); 2.3006 (16.0); 2.0831 (0.9); 1.6302 (2.5); 1.3209 (0.6); 1.2948 (3.1); 1.2734 (0.6); 1.0201 (1.0); 0.9969 (4.2); 0.9796 (4.4); 0.9741 (3.4); 0.9569 (1.4); 0.9258 (0.4); 0.9189 (0.5); 0.9041 (0.4); 0.8935 (0.4); 0.7484 (1.4); 0.7318 (3.5); 0.7250 (4.0); 0.7196 (3.6); 0.7141 (3.3); 0.6963 (1.0); 0.0489 (0.4); 0.0382 (9.3); 0.0273 (0.3)
I-044:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.8277 (1.7); 7.9522 (0.4); 7.7599 (3.9); 7.7430 (0.5); 7.7236 (1.2); 7.7039 (0.9); 7.6571 (3.4); 7.6376 (0.8); 7.5972 (1.1); 7.5780 (0.7); 7.3279 (2.6); 7.3075 (3.2); 7.0599 (2.7); 7.0398 (2.3); 3.3821 (17.7); 3.3732 (15.6); 3.3681 (17.4); 3.3562 (18.9); 2.8906 (2.6); 2.7322 (2.3); 2.6121 (11.7); 2.5217 (0.4); 2.5131 (6.0); 2.5087 (12.7); 2.5042 (17.1); 2.4996 (12.2); 2.4951 (5.9); 2.2440 (9.0); 1.6126 (16.0); -0.0002 (0.4)
I-045:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5397 (0.6); 7.5242 (1.6); 7.5086 (1.8); 7.4990 (2.0); 7.4831 (0.8); 7.4660 (2.0); 7.4346 (2.2); 7.4179 (2.6); 7.4044 (2.0); 7.4010 (2.9); 7.3986 (2.6); 7.3811 (0.9); 7.2614 (7.1); 7.2287 (1.6); 7.2246 (1.4); 7.2119 (1.3); 7.2079 (1.2); 6.3927 (0.6); 6.3807 (0.9); 6.3687 (0.5); 6.0186 (0.5); 6.0126 (0.6); 6.0039 (0.6); 5.9979 (0.5); 5.9250 (0.5); 5.9190 (0.6); 5.9103 (0.6); 5.9043 (0.5); 4.2254 (0.3); 4.2179 (0.3); 4.2118 (0.3); 4.2021 (0.4); 4.1960 (0.4); 4.1885 (0.4); 4.1823 (0.4); 4.1756 (0.3); 4.1619 (0.3); 4.1461 (0.4); 4.1399 (0.4); 4.1325 (0.4); 3.8462 (0.4); 3.8350 (0.4); 3.8316 (0.4); 3.8203 (0.4); 3.8169 (0.4); 3.8044 (0.6); 3.7924 (0.6); 3.7908 (0.6); 3.7782 (0.4); 3.7748 (0.3); 3.7635 (0.3); 2.7056 (0.5); 2.6943 (0.7); 2.6906 (0.8); 2.6793 (1.8); 2.6666 (2.7); 2.6594 (16.0); 2.6521 (1.8); 2.6401 (0.5); 2.6373 (0.5); 2.0773 (0.4); 2.0010 (10.0); 1.5767 (2.0); 1.2572 (3.5); 1.2421 (7.0); 1.2269 (3.0); 0.0061 (0.4); -0.0002 (6.3)
I-046:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0811 (0.6); 9.0655 (1.4); 9.0497 (0.6); 8.3100 (0.7); 7.7379 (0.6); 7.7183 (1.7); 7.6985 (1.5); 7.6694 (1.8); 7.6579 (6.4); 7.6502 (1.1); 7.5979 (2.1); 7.5329 (1.2); 7.5143 (3.3); 7.4939 (2.6); 7.4566 (2.6); 7.1344 (1.3); 7.1312 (1.3); 7.1142 (1.2); 7.1108 (1.2); 4.2726 (0.6); 4.2569 (0.6); 4.2372 (1.4); 4.2214 (1.3); 4.2015 (0.7); 4.1854 (0.6); 3.9603 (1.4); 3.9417 (1.9); 3.9216 (1.7); 3.9129 (0.7); 3.9036 (1.5); 3.8920 (1.5); 3.8828 (0.9); 3.8712 (0.8); 3.7844 (0.9); 3.7654 (2.2); 3.7450 (1.8); 3.7258 (0.7); 3.4830 (1.5); 3.4652 (2.1); 3.4625 (1.6); 3.4445 (1.8); 3.3809 (0.4); 3.3621 (1.2); 3.3426 (2.1); 3.3238 (181.8); 2.7118 (0.4); 2.6808 (0.3); 2.6761 (0.7); 2.6716 (0.9); 2.6670 (0.7); 2.6624 (0.3); 2.5822 (16.0); 2.5417 (94.9); 2.5250 (2.8); 2.5202 (4.2); 2.5116 (54.2); 2.5071 (107.5); 2.5025 (140.3); 2.4980 (101.6); 2.4935 (49.2); 2.3682 (0.4); 2.3339 (0.6); 2.3293 (0.9); 2.3248 (0.6); 2.2921 (0.4); 2.2805 (0.4); 2.2729 (0.6); 2.2612 (0.9); 2.2525 (0.5); 2.2499 (0.5); 2.2414 (0.9); 2.2302 (0.6); 2.2220 (0.4); 2.2104 (0.4); 1.8433 (0.4); 1.8239 (1.0); 1.8124 (0.4); 1.8037 (1.0); 1.7932 (0.9); 1.7842 (0.4); 1.7730 (0.8); 1.7535 (0.3); -0.0002 (1.6)
I-047:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5817 (2.3); 7.4052 (0.6); 7.3774 (3.9); 7.3704 (2.9); 7.3650 (2.4); 7.3425 (0.4); 7.3369 (0.4); 7.2983 (10.9); 7.1501 (0.5); 7.1451 (0.4); 7.1345 (0.3); 7.1228 (1.8); 7.1142 (1.3); 7.1019 (3.6); 7.0930 (1.3); 7.0859 (1.4); 7.0660 (0.4); 6.8681 (0.6); 6.8556 (0.7); 6.8466 (1.0); 6.8375 (1.0); 6.8212 (0.6); 6.8141 (0.6); 6.5223 (0.4); 6.5039 (0.8); 6.4828 (0.4); 6.0902 (0.5); 6.0794 (0.6); 6.0687 (0.6); 6.0579 (0.5); 5.9357 (0.5); 5.9250 (0.5); 5.9144 (0.6); 5.9037 (0.5); 4.2173 (0.4); 4.2061 (0.4); 4.1954 (0.4); 4.1841 (0.5); 4.1339 (0.4); 4.1229 (0.4); 4.1123 (0.4); 4.0262 (0.3); 4.0056 (0.6); 3.9847 (0.4); 3.9565 (0.4); 3.9482 (0.4); 3.9280 (0.6); 3.9069 (0.4); 3.8787 (0.4); 3.8576 (0.4); 2.4597 (1.6); 2.4459 (16.0); 2.1560 (0.4); 2.1386 (0.5); 2.1274 (0.5); 2.1103 (0.9); 2.0928 (0.6); 2.0819 (0.6); 2.0423 (1.4); 1.5977 (3.1); 1.0814 (0.7); 1.0661 (1.9); 1.0592 (2.0); 1.0444 (1.1); 1.0375 (2.0); 1.0310 (1.8); 1.0163 (0.9); 0.8243 (0.9); 0.8092 (2.3); 0.8038 (2.1); 0.7923 (2.0); 0.7869 (2.4); 0.7703 (0.7); 0.1073 (0.8); 0.0481 (0.4); 0.0374 (10.8); 0.0265 (0.4)
I-048:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0374 (1.5); 9.0160 (1.5); 7.8268 (6.6); 7.7205 (0.6); 7.7005 (1.6); 7.6813 (1.4); 7.6427 (1.9); 7.6238 (3.5); 7.5812 (1.4); 7.5591 (1.1); 7.3366 (3.0); 7.2483 (7.6); 5.1457 (0.8); 5.1292 (0.8); 5.1111 (0.3); 4.0555 (0.4); 4.0377 (1.1); 4.0199 (1.2); 4.0022 (0.4); 3.3230 (16.5); 2.7648 (0.6); 2.7502 (1.5); 2.7391 (1.6); 2.6702 (0.4); 2.6063 (16.0); 2.5234 (1.0); 2.5100 (22.6); 2.5057 (45.1); 2.5013 (58.8); 2.4969 (42.4); 2.4926 (20.8); 2.3282 (0.3); 2.0150 (0.4); 1.9888 (5.5); 1.9714 (0.6); 1.9563 (0.5); 1.8850 (0.4); 1.8655 (0.5); 1.8588 (0.6); 1.8398 (0.5); 1.7950 (0.3); 1.7716 (1.0); 1.7531 (1.3); 1.7305 (1.0); 1.3970 (0.6); 1.1922 (1.3); 1.1744 (2.5); 1.1567 (1.2); -0.0002 (0.9)
I-049:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 11.7200 (2.0); 7.9527 (1.0); 7.8648 (1.0); 7.8288 (5.6); 7.7341 (0.7); 7.7144 (2.1); 7.6946 (1.7); 7.6632 (2.2); 7.6435 (1.2); 7.6076 (0.6); 7.5901 (2.4); 7.5506 (1.4); 7.5313 (1.0); 7.3642 (0.3); 7.1997 (2.3); 7.1806 (2.6); 7.1583 (0.4); 7.1273 (0.3); 7.1091 (0.3); 7.0279 (0.9); 7.0122 (2.9); 6.8897 (1.5); 6.8706 (1.3); 5.0383 (1.5); 4.9271 (7.7); 4.6788 (0.5); 3.3333 (30.3); 2.8917 (6.8); 2.7333 (6.0); 2.6104 (3.2); 2.5986 (16.0); 2.5367 (0.5); 2.5262 (1.7); 2.5120 (13.1); 2.5077 (25.7); 2.5033 (33.3); 2.4987 (24.2); 2.4944 (11.9); 2.4291 (4.6); 2.3808 (12.3); 2.2717 (0.9); 2.2271 (12.0); 2.0020 (0.4); 1.8525 (0.8); 1.2403 (1.2); -0.0002 (1.0)
I-050:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.0846 (0.4); 9.0652 (0.8); 9.0457 (0.4); 7.7138 (0.9); 7.6877 (0.8); 7.6604 (1.0); 7.6346 (0.4); 7.5464 (1.2); 7.5198 (0.7); 7.4859 (1.3); 7.4566 (2.4); 7.4214 (2.7); 7.3931 (1.1); 5.8316 (0.3); 5.7784 (0.4); 5.6747 (0.3); 3.8795 (0.4); 3.8585 (0.4); 3.8330 (0.4); 3.8107 (0.4); 3.7899 (0.4); 3.3498 (16.0); 2.7092 (1.0); 2.5528 (7.2); 2.5341 (1.5); 2.5281 (3.1); 2.5220 (4.2); 2.5159 (3.0); 2.5100 (1.4); 2.1706 (7.0); 0.0199 (3.3)
I-051:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.3477 (2.7); 9.3354 (5.3); 9.3230 (2.6); 8.3085 (3.3); 8.2927 (6.4); 8.2769 (3.7); 8.0907 (16.0); 7.8894 (7.7); 7.8743 (8.0); 7.8573 (9.2); 7.8380 (0.4); 7.7034 (0.9); 7.6865 (0.9); 7.5981 (6.9); 7.5816 (6.6); 7.5517 (1.4); 7.5348 (1.1); 7.4994 (5.6); 7.4824 (9.1); 7.4347 (6.3); 7.4179 (3.8); 4.2091 (2.4); 4.1966 (2.7); 4.1815 (5.2); 4.1690 (5.0); 4.1538 (2.8); 4.1413 (2.4); 3.3379 (7.9); 3.3129 (1.0); 3.2827 (1.9); 3.2526 (1.0); 2.5092 (3.2); -0.0002 (1.1)
I-052:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1324 (0.8); 8.1121 (1.5); 8.0925 (0.8); 7.6143 (0.8); 7.5884 (2.6); 7.5636 (6.4); 7.5573 (3.4); 7.5456 (13.2); 7.4917 (4.2); 7.4624 (9.4); 7.4546 (4.5); 7.4025 (8.6); 7.3749 (5.2); 7.2983 (20.7); 5.3369 (16.0); 4.2546 (2.0); 4.2343 (1.9); 4.2078 (4.3); 4.1875 (4.1); 4.1611 (2.1); 4.1408 (2.1); 3.5918 (3.8); 3.5695 (10.4); 3.5475 (4.0); 2.1254 (0.4); 2.1054 (4.3); 2.0933 (4.4); 2.0832 (11.8); 2.0729 (4.4); 2.0609 (4.0); 2.0415 (0.4); 1.5990 (6.5); 1.2921 (0.8); 0.1067 (0.7); 0.0472 (0.7); 0.0365 (21.0); 0.0256 (0.7)
I-053:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5319 (0.5); 7.5165 (1.7); 7.5008 (1.9); 7.4913 (2.2); 7.4751 (0.9); 7.4645 (2.2); 7.4060 (1.4); 7.3907 (1.0); 7.3685 (2.2); 7.3527 (2.4); 7.2606 (7.2); 7.1939 (2.6); 7.0498 (1.5); 7.0343 (1.3); 6.3172 (0.6); 6.3058 (1.0); 6.2939 (0.6); 6.0331 (0.5); 6.0268 (0.6); 6.0183 (0.6); 6.0120 (0.5); 5.9393 (0.5); 5.9330 (0.6); 5.9244 (0.6); 5.9182 (0.5); 5.2979 (4.4); 4.2170 (0.4); 4.2106 (0.4); 4.2032 (0.4); 4.1967 (0.4); 4.1907 (0.3); 4.1843 (0.3); 4.1768 (0.3); 4.1615 (0.4); 4.1550 (0.4); 4.1476 (0.4); 4.1411 (0.3); 3.8423 (0.3); 3.8317 (0.4); 3.8276 (0.4); 3.8167 (0.4); 3.8135 (0.4); 3.8019 (0.7); 3.7906 (0.5); 3.7873 (0.6); 3.7761 (0.4); 3.7726 (0.3); 3.7617 (0.3); 2.7104 (0.6); 2.7063 (0.7); 2.6953 (1.8); 2.6909 (1.8); 2.6801 (1.9); 2.6759 (1.9); 2.6617 (16.0); 2.3065 (11.3); 1.5703 (5.2); 1.2613 (3.4); 1.2462 (7.1); 1.2390 (0.7); 1.2310 (3.2); -0.0002 (6.5)
I-054:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3029 (16.0); 7.9498 (1.9); 7.7222 (0.6); 7.6937 (6.2); 7.6796 (14.0); 7.6496 (0.5); 7.5446 (4.6); 7.5172 (2.7); 7.4890 (9.6); 7.4796 (2.4); 7.4704 (7.4); 7.4652 (7.4); 7.4502 (2.0); 7.4418 (2.6); 7.3039 (56.4); 5.3437 (0.4); 4.4985 (2.6); 4.4779 (2.5); 4.4500 (5.5); 4.4295 (5.3); 4.4015 (2.7); 4.3810 (2.6); 1.5974 (44.8); 1.2977 (0.7); 0.1119 (3.9); 0.0530 (2.0); 0.0423 (51.4); 0.0312 (1.6)
I-055:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.7835 (2.6); 9.2088 (1.2); 9.1882 (2.4); 9.1681 (1.2); 8.0017 (0.4); 7.9483 (13.7); 7.3533 (3.7); 7.3267 (4.3); 7.2937 (2.1); 7.2843 (0.7); 7.2653 (3.8); 7.2431 (1.2); 7.2375 (2.2); 7.1133 (4.4); 7.0084 (2.4); 6.9821 (2.2); 6.7366 (2.4); 6.7321 (2.5); 6.7124 (1.9); 6.7079 (2.3); 6.7021 (2.0); 6.6529 (2.1); 6.6486 (3.2); 6.6360 (3.4); 6.6286 (7.5); 6.6231 (6.8); 6.2130 (0.5); 5.7860 (1.4); 4.1426 (1.2); 4.1219 (1.2); 4.0932 (2.6); 4.0727 (2.5); 4.0435 (1.4); 4.0230 (1.3); 3.3582 (17.6); 2.5341 (6.5); 2.5281 (8.5); 2.5222 (6.2); 2.4780 (0.4); 2.4420 (11.9); 2.2722 (16.0); 0.0367 (0.5); 0.0259 (9.9); 0.0151 (0.4)
I-056:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6142 (0.4); 7.5880 (2.0); 7.5684 (5.4); 7.5652 (5.1); 7.5518 (0.4); 7.5482 (0.4); 7.4708 (2.4); 7.4500 (0.4); 7.4338 (1.1); 7.4237 (1.6); 7.4164 (1.3); 7.4030 (1.1); 7.3953 (0.6); 7.2974 (14.1); 7.0527 (2.2); 7.0271 (3.1); 7.0021 (2.7); 6.9123 (1.6); 6.8864 (1.1); 6.7641 (1.7); 6.7249 (2.0); 6.7050 (2.2); 6.6658 (2.3); 6.1252 (3.8); 6.0662 (3.1); 6.0154 (0.6); 5.9968 (1.1); 5.9764 (0.6); 5.8682 (3.6); 5.8289 (3.3); 3.7732 (1.4); 3.7505 (3.6); 3.7299 (3.6); 3.7075 (1.5); 3.1760 (0.6); 2.9577 (0.6); 2.9483 (2.2); 2.9256 (4.4); 2.9027 (2.0); 2.3681 (0.6); 2.3187 (16.0); 2.2947 (14.2); 2.2091 (0.6); 1.6312 (0.6); 1.6097 (8.2); 1.2907 (0.9); 0.1065 (1.3); 0.0469 (0.4); 0.0361 (11.3); 0.0252 (0.4)
I-057:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1130 (1.6); 9.0985 (3.4); 9.0840 (1.8); 8.3767 (14.9); 7.7947 (1.2); 7.7756 (3.9); 7.7435 (16.0); 7.7247 (2.6); 7.6585 (3.7); 7.6393 (2.6); 7.5052 (1.7); 7.4842 (10.9); 7.4792 (8.3); 7.4752 (7.2); 7.4580 (1.4); 7.4542 (1.5); 6.0746 (1.2); 6.0613 (2.1); 6.0496 (1.3); 5.9593 (1.2); 5.9462 (2.3); 5.9343 (1.3); 3.9315 (1.8); 3.9166 (2.8); 3.9085 (1.7); 3.9013 (1.5); 3.8740 (2.2); 3.8596 (3.2); 3.8485 (1.6); 3.3018 (54.6); 2.5049 (18.0); 2.5007 (24.5); 2.4964 (18.7); 2.0718 (1.4); -0.0002 (8.8)
I-058:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1613 (9.7); 9.1495 (10.3); 9.0079 (2.0); 8.9935 (4.1); 8.9786 (2.2); 7.9613 (2.4); 7.8576 (10.1); 7.8458 (10.1); 7.7625 (1.7); 7.7432 (5.1); 7.7235 (4.8); 7.6993 (5.9); 7.6685 (7.4); 7.6267 (7.6); 7.5996 (4.3); 7.5793 (3.6); 7.5700 (7.7); 7.5489 (8.9); 7.3765 (4.8); 7.3713 (5.0); 7.3554 (4.2); 7.3503 (4.1); 6.0788 (1.4); 6.0664 (2.8); 6.0534 (1.6); 5.9636 (1.4); 5.9511 (2.8); 5.9382 (1.6); 3.9147 (1.9); 3.9029 (4.2); 3.8883 (2.8); 3.8618 (2.0); 3.8575 (2.0); 3.8468 (4.0); 3.8319 (2.6); 3.8086 (0.4); 3.3133 (170.5); 2.8991 (16.0); 2.7402 (14.3); 2.5136 (21.6); 2.5092 (29.9); 2.5049 (22.6)
I-059:1 H-NMR(400.0 MHz, CD3CN): δ= 7.9967 (1.3); 7.9566 (16.0); 7.9308 (6.6); 7.9104 (7.0); 7.7990 (1.8); 7.7357 (1.4); 7.7163 (4.4); 7.6967 (5.0); 7.6873 (6.1); 7.6675 (1.8); 7.5952 (0.5); 7.5707 (6.2); 7.5692 (6.1); 7.5288 (0.3); 7.5066 (3.6); 7.4871 (2.6); 7.2808 (6.2); 7.2604 (5.8); 5.4456 (1.1); 4.3717 (3.3); 4.3552 (3.3); 4.3387 (6.8); 4.3222 (6.7); 4.3058 (3.5); 4.2893 (3.4); 4.1591 (0.6); 4.1425 (0.6); 4.0677 (0.3); 4.0499 (0.3); 2.1295 (10.6); 1.9713 (1.6); 1.9635 (1.2); 1.9573 (3.2); 1.9516 (16.3); 1.9454 (29.4); 1.9393 (39.4); 1.9331 (27.1); 1.9269 (14.0); 1.2697 (0.4); 1.2214 (0.4); 1.2035 (0.8); 1.1858 (0.4); 0.1461 (0.4); 0.0079 (3.6); -0.0002 (89.3); -0.0073 (3.6); -0.0085 (3.7); -0.1494 (0.4)
I-060:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1650 (9.5); 9.1533 (9.8); 9.0205 (3.8); 8.9995 (3.9); 7.9612 (1.0); 7.9336 (9.9); 7.9219 (9.6); 7.7501 (1.5); 7.7305 (4.4); 7.7100 (4.0); 7.6756 (13.4); 7.6587 (3.1); 7.6240 (4.4); 7.6057 (2.9); 6.8916 (16.0); 5.0722 (1.0); 5.0546 (2.2); 5.0391 (2.2); 5.0208 (1.0); 3.3132 (157.4); 2.8991 (5.8); 2.7401 (5.2); 2.6641 (5.8); 2.6506 (3.4); 2.6221 (0.3); 2.5134 (20.8); 2.5090 (27.8); 2.5047 (20.4); 2.0378 (0.7); 2.0240 (1.4); 2.0180 (1.2); 2.0109 (1.7); 1.9932 (1.6); 1.9782 (2.2); 1.9674 (1.2); 1.9480 (1.3); 1.9422 (1.3); 1.9347 (1.6); 1.9291 (1.8); 1.9154 (1.4); 1.8559 (0.6); 1.8378 (1.2); 1.8211 (1.5); 1.8151 (1.4); 1.8044 (1.2); 1.7981 (1.1); 1.7871 (1.0); 1.7698 (0.6); 1.7474 (1.2); 1.7279 (1.8); 1.7223 (1.7); 1.7035 (1.6); 1.6975 (1.6); 1.6783 (0.7)
I-061:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1556 (1.8); 8.1659 (4.9); 7.9557 (0.4); 7.7859 (0.9); 7.7681 (1.5); 7.7600 (2.2); 7.7520 (1.8); 7.7308 (1.2); 7.7029 (2.0); 7.6961 (2.0); 7.6912 (1.7); 7.6440 (1.0); 7.6235 (0.7); 7.5667 (0.4); 7.5470 (1.9); 7.5422 (2.1); 7.5233 (1.2); 7.5041 (0.4); 3.3679 (14.5); 3.3616 (18.3); 3.3567 (17.9); 2.8932 (2.8); 2.7352 (2.5); 2.5159 (4.2); 2.5115 (8.9); 2.5070 (12.0); 2.5025 (8.6); 2.4981 (4.2); 1.6906 (16.0)
I-062:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4540 (1.9); 7.4373 (1.7); 7.4265 (4.1); 7.3475 (1.2); 7.3212 (2.6); 7.2988 (10.6); 7.2283 (1.5); 7.2219 (1.4); 7.2003 (1.1); 7.1936 (1.2); 7.0151 (1.4); 6.9929 (1.9); 6.9899 (2.1); 6.9853 (2.2); 6.9663 (0.8); 6.9634 (0.8); 6.9584 (1.1); 6.9059 (1.6); 6.8995 (2.1); 6.8928 (1.2); 6.6096 (0.5); 6.5887 (0.8); 6.5686 (0.5); 6.0795 (0.4); 6.0689 (0.5); 6.0569 (0.5); 6.0465 (0.5); 5.9244 (0.5); 5.9140 (0.5); 5.9020 (0.5); 5.8916 (0.5); 4.1924 (0.4); 4.1819 (0.4); 4.1704 (0.4); 4.1599 (0.4); 4.1547 (0.3); 4.1055 (0.4); 4.0949 (0.3); 4.0836 (0.3); 4.0730 (0.3); 3.9551 (0.3); 3.9335 (0.5); 3.9129 (0.4); 3.8799 (0.4); 3.8599 (0.5); 3.8374 (0.4); 3.8105 (0.4); 2.4139 (16.0); 1.9615 (0.5); 1.9503 (0.6); 1.9335 (1.1); 1.9167 (0.6); 1.9056 (0.6); 1.8887 (0.3); 1.5969 (6.8); 1.3054 (1.7); 1.0399 (0.7); 1.0246 (1.8); 1.0179 (2.0); 1.0030 (1.2); 0.9963 (2.0); 0.9896 (1.8); 0.9751 (1.0); 0.9418 (0.6); 0.9203 (1.9); 0.8968 (0.7); 0.7582 (0.9); 0.7429 (2.3); 0.7368 (2.1); 0.7266 (2.0); 0.7207 (2.4); 0.7045 (0.8); 0.1080 (0.8); 0.0489 (0.4); 0.0382 (10.0); 0.0273 (0.4)
I-063:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3849 (1.6); 7.3582 (1.8); 7.3298 (1.0); 7.3033 (2.7); 7.2987 (9.0); 7.2772 (1.4); 7.0892 (1.7); 7.0036 (2.1); 6.9819 (2.1); 6.9776 (2.9); 6.9588 (0.8); 6.9558 (0.7); 6.9508 (1.0); 6.9478 (0.9); 6.8944 (1.4); 6.8880 (1.8); 6.8813 (1.1); 6.5426 (0.4); 6.5226 (0.8); 6.5030 (0.4); 5.3373 (3.0); 4.2577 (0.8); 4.2367 (0.8); 4.2092 (1.8); 4.1882 (1.7); 4.1606 (0.9); 4.1396 (0.8); 2.5263 (5.2); 2.5196 (3.0); 2.3521 (16.0); 2.3441 (7.8); 1.9528 (0.5); 1.9415 (0.5); 1.9248 (1.0); 1.9134 (0.4); 1.9080 (0.5); 1.8968 (0.5); 1.5920 (2.4); 1.0326 (0.6); 1.0174 (1.6); 1.0106 (1.8); 1.0049 (1.0); 0.9957 (1.0); 0.9890 (1.8); 0.9823 (1.6); 0.9677 (0.8); 0.7511 (0.8); 0.7359 (2.0); 0.7297 (1.8); 0.7195 (1.7); 0.7137 (2.2); 0.6974 (0.6); 0.0393 (8.5)
I-064:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5316 (0.3); 7.5084 (1.0); 7.4364 (0.5); 7.3907 (0.4); 7.3823 (0.6); 7.3553 (0.6); 7.2983 (2.8); 7.0800 (0.5); 4.1765 (0.4); 4.1557 (0.4); 3.3426 (0.7); 3.3263 (0.7); 2.4992 (1.5); 2.4921 (0.8); 2.3427 (2.1); 1.5893 (2.0); 1.3507 (6.6); 0.2343 (0.8); 0.2233 (16.0); 0.2137 (0.5); 0.2123 (0.6); 0.0384 (3.0)
I-065:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2969 (13.4); 8.0973 (0.8); 8.0806 (1.4); 7.5107 (1.8); 7.4846 (4.3); 7.4582 (2.7); 7.3709 (3.6); 7.3444 (4.1); 7.2985 (26.4); 7.2673 (2.6); 7.2409 (2.1); 7.1761 (1.7); 7.1707 (2.4); 7.1407 (4.8); 7.1340 (3.9); 7.0734 (3.9); 6.9868 (2.1); 6.9603 (1.8); 4.2952 (2.0); 4.2753 (1.9); 4.2470 (4.3); 4.2271 (4.1); 4.1986 (2.3); 4.1789 (2.2); 4.1726 (1.3); 4.1487 (1.0); 4.1248 (0.3); 2.8917 (0.8); 2.8644 (0.9); 2.8502 (1.2); 2.8233 (1.3); 2.8094 (0.9); 2.7822 (0.9); 2.5181 (6.4); 2.5112 (11.8); 2.5037 (6.5); 2.3244 (16.0); 2.0836 (4.7); 2.0442 (2.1); 1.9862 (0.7); 1.9694 (0.8); 1.9596 (0.9); 1.9453 (1.2); 1.9292 (1.1); 1.9194 (1.3); 1.9034 (1.4); 1.8896 (0.7); 1.8798 (0.9); 1.8629 (0.9); 1.7413 (0.8); 1.7280 (0.9); 1.7144 (1.5); 1.7009 (1.9); 1.6862 (1.3); 1.6722 (1.8); 1.6588 (1.7); 1.6452 (1.0); 1.6320 (1.1); 1.5941 (1.5); 1.3219 (1.3); 1.2981 (2.7); 1.2743 (1.2); 0.1087 (1.2); 0.0497 (1.2); 0.0389 (32.4); 0.0280 (1.1)
I-066:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3253 (0.5); 9.3056 (0.5); 9.1648 (1.4); 9.1451 (1.4); 8.8116 (0.6); 8.8085 (0.7); 8.8005 (0.7); 8.7974 (0.7); 8.7574 (0.6); 8.7545 (0.6); 8.7365 (0.7); 8.7335 (0.6); 8.4007 (2.5); 7.7066 (0.6); 7.6874 (1.7); 7.6683 (1.9); 7.6576 (1.2); 7.6477 (0.8); 7.6362 (2.0); 7.6291 (3.0); 7.6083 (1.3); 7.5899 (2.3); 7.5627 (0.6); 7.5315 (1.4); 7.5091 (1.1); 7.4915 (7.7); 7.4665 (1.2); 7.4452 (1.7); 7.4093 (3.0); 7.3881 (5.1); 7.3633 (2.0); 7.3469 (0.7); 7.3419 (1.6); 7.3383 (1.3); 7.3324 (5.9); 7.3158 (1.4); 7.3111 (3.3); 5.1550 (0.4); 5.1012 (0.8); 5.0830 (1.2); 5.0647 (0.8); 3.9924 (16.0); 3.9031 (3.9); 3.4801 (0.5); 3.3277 (98.7); 2.6759 (0.8); 2.6715 (1.1); 2.6670 (0.8); 2.5247 (4.8); 2.5112 (74.4); 2.5070 (142.2); 2.5026 (181.2); 2.4981 (132.5); 2.4939 (67.8); 2.3338 (0.8); 2.3293 (1.0); 2.3249 (0.8); 1.4717 (2.0); 1.4543 (2.0); 1.4169 (6.0); 1.3994 (6.0); 1.3765 (0.6); 1.2355 (0.4); -0.0001 (0.7)
I-067:1 H-NMR(400.0 MHz, CD3CN): δ= 7.9759 (16.0); 7.9610 (0.3); 7.8057 (1.6); 7.7210 (1.4); 7.7016 (4.6); 7.6819 (7.1); 7.6759 (6.6); 7.6563 (1.7); 7.5779 (1.7); 7.5552 (7.5); 7.5405 (3.5); 7.5186 (1.8); 7.5035 (3.8); 7.4849 (2.9); 7.0514 (1.6); 7.0460 (1.6); 7.0232 (3.0); 7.0004 (1.4); 6.9950 (1.5); 6.9135 (1.6); 6.9090 (1.5); 6.8920 (3.0); 6.8707 (1.5); 5.4454 (1.4); 4.2524 (3.2); 4.2360 (3.2); 4.2182 (6.6); 4.2018 (6.5); 4.1839 (3.3); 4.1675 (3.3); 4.0677 (0.4); 4.0499 (0.4); 2.1321 (8.3); 1.9712 (1.9); 1.9633 (1.1); 1.9571 (2.7); 1.9514 (13.1); 1.9453 (23.5); 1.9392 (31.4); 1.9330 (21.6); 1.9268 (11.1); 1.2686 (0.6); 1.2214 (0.5); 1.2036 (0.9); 1.1857 (0.5); 0.9756 (0.4); 0.1460 (0.4); 0.0078 (3.1); -0.0002 (69.0); -0.1496 (0.4)
I-068:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.8340 (1.7); 8.8202 (3.4); 8.8063 (1.7); 8.7328 (5.5); 8.0979 (16.0); 7.9143 (2.9); 7.9085 (3.0); 7.8937 (3.3); 7.8880 (3.3); 7.7372 (1.3); 7.7177 (4.4); 7.6979 (5.9); 7.6906 (6.1); 7.6710 (1.8); 7.6267 (6.1); 7.5615 (3.6); 7.5349 (5.9); 7.5138 (4.6); 3.7726 (2.2); 3.7567 (6.0); 3.7413 (6.2); 3.7255 (2.5); 3.3433 (50.4); 3.1469 (4.0); 3.1305 (7.7); 3.1142 (3.7); 2.8945 (0.5); 2.7357 (0.5); 2.5115 (23.4); 2.5074 (30.8); 2.5031 (22.9); 1.2396 (1.2); -0.0002 (4.0)
I-069:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1170 (1.9); 9.1015 (4.0); 9.0855 (2.1); 8.2929 (0.3); 8.2140 (15.5); 7.9610 (1.4); 7.8416 (7.6); 7.6666 (1.9); 7.6467 (4.9); 7.6267 (3.8); 7.5725 (4.9); 7.5529 (3.3); 7.5308 (16.0); 7.4424 (2.6); 7.4380 (2.6); 7.4211 (5.2); 7.4169 (5.5); 7.3801 (9.6); 7.3690 (6.9); 7.3592 (5.9); 7.3183 (3.6); 7.2979 (3.3); 7.2934 (3.0); 4.1716 (1.9); 4.1560 (2.1); 4.1371 (4.3); 4.1214 (4.4); 4.1024 (2.4); 4.0867 (2.2); 3.3133 (201.7); 2.8994 (8.5); 2.7404 (7.8); 2.5137 (23.8); 2.5094 (32.9); 2.5051 (25.3); 2.4545 (0.5)
I-070:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3418 (1.9); 9.3263 (4.0); 9.3105 (2.0); 7.9619 (2.6); 7.8969 (6.7); 7.8934 (6.7); 7.7706 (1.5); 7.7507 (4.4); 7.7311 (4.2); 7.7125 (5.3); 7.6927 (2.4); 7.6190 (6.1); 7.5672 (3.5); 7.5475 (2.9); 7.4987 (4.5); 7.4775 (7.4); 7.4203 (4.5); 7.4164 (4.4); 7.3995 (2.8); 7.3952 (2.8); 4.3606 (1.6); 4.3448 (1.8); 4.3253 (3.6); 4.3097 (3.6); 4.2894 (2.0); 4.2738 (1.9); 3.5458 (4.2); 3.5282 (9.5); 3.5108 (5.0); 3.3148 (40.0); 3.2544 (44.9); 3.2324 (1.3); 3.2037 (0.5); 2.8997 (16.0); 2.8783 (4.3); 2.8609 (7.8); 2.8433 (4.0); 2.7407 (14.4); 2.5140 (25.0); 2.5098 (33.4); 2.5055 (25.2)
I-071:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9675 (3.6); 8.9468 (3.6); 8.3636 (0.4); 8.3376 (15.3); 7.9609 (1.4); 7.7911 (0.4); 7.7725 (16.0); 7.6337 (2.0); 7.6139 (4.8); 7.5939 (3.3); 7.5250 (4.7); 7.5058 (3.1); 7.3417 (6.1); 7.3074 (3.6); 7.2868 (3.0); 6.6696 (15.1); 4.8696 (0.9); 4.8500 (2.0); 4.8377 (1.9); 4.8201 (1.0); 3.3128 (175.6); 2.8992 (9.4); 2.7400 (8.4); 2.6506 (0.3); 2.6093 (4.1); 2.5992 (4.3); 2.5582 (0.5); 2.5134 (21.3); 2.5090 (28.8); 2.5047 (21.3); 1.8432 (0.6); 1.8122 (3.0); 1.7994 (3.3); 1.7870 (3.0); 1.7538 (0.9); 1.7407 (0.6); 1.7150 (1.3); 1.6971 (1.4); 1.6819 (1.1); 1.6560 (0.5); 1.5460 (0.3); 1.5267 (1.1); 1.5078 (1.9); 1.4859 (1.6); 1.4610 (0.8)
I-072:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5664 (3.0); 7.5626 (2.5); 7.5573 (4.4); 7.4545 (2.5); 7.4051 (1.0); 7.3969 (1.4); 7.3933 (1.2); 7.3875 (1.0); 7.3825 (0.6); 7.3196 (2.2); 7.3036 (2.3); 7.2598 (3.8); 6.9924 (2.8); 6.8282 (1.5); 6.8124 (1.4); 6.5730 (0.7); 6.5655 (0.9); 6.5583 (0.8); 6.5511 (0.7); 5.2962 (2.5); 4.5774 (0.4); 4.5717 (0.4); 4.5612 (0.4); 4.5550 (0.4); 4.5507 (0.4); 4.5448 (0.5); 4.5339 (0.3); 4.5285 (0.4); 3.8495 (0.3); 3.8405 (0.4); 3.8306 (0.5); 3.8211 (0.5); 3.8127 (0.5); 3.8045 (0.4); 3.1446 (16.0); 2.4477 (7.7); 2.2214 (10.3); 1.2555 (0.7); -0.0002 (4.7)
I-073:1 H-NMR(400.0 MHz, CD3CN): δ= 8.2415 (6.0); 8.2366 (6.3); 8.1662 (1.5); 8.0912 (16.0); 8.0065 (6.6); 8.0015 (6.3); 7.7094 (1.0); 7.6897 (4.0); 7.6718 (11.1); 7.6544 (1.0); 7.5141 (5.4); 7.4684 (2.0); 7.4629 (3.6); 7.4577 (2.1); 7.4524 (1.4); 7.4458 (2.6); 4.4476 (3.2); 4.4313 (3.2); 4.4145 (6.8); 4.3982 (6.7); 4.3814 (3.4); 4.3651 (3.4); 2.1293 (18.4); 1.9635 (1.3); 1.9574 (3.2); 1.9516 (17.3); 1.9454 (31.3); 1.9393 (42.1); 1.9331 (29.2); 1.9269 (15.1); 1.2685 (0.4); 0.1460 (0.4); 0.0079 (3.7); -0.0002 (93.6); -0.0084 (4.2); -0.1497 (0.5)
I-074:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1051 (0.9); 9.0909 (1.9); 9.0759 (1.0); 7.9619 (1.9); 7.7580 (3.6); 7.7227 (0.9); 7.7030 (2.4); 7.6831 (1.9); 7.6470 (2.5); 7.6289 (1.7); 7.5354 (3.0); 7.5207 (1.2); 7.5162 (1.1); 7.4997 (4.6); 7.4957 (3.9); 7.4802 (6.1); 7.4592 (1.7); 7.2873 (0.4); 6.0275 (0.6); 6.0151 (1.2); 6.0026 (0.6); 5.9121 (0.6); 5.8997 (1.3); 5.8870 (0.6); 3.9219 (1.1); 3.9083 (1.8); 3.8944 (1.1); 3.8638 (1.1); 3.8499 (1.9); 3.8361 (1.1); 3.3153 (20.8); 2.9308 (0.3); 2.8997 (11.6); 2.7407 (10.4); 2.5463 (16.4); 2.5141 (12.1); 2.5098 (16.2); 2.5055 (12.3); 2.1730 (16.0)
I-075:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.7145 (2.2); 8.7012 (1.2); 8.3161 (0.6); 8.0485 (16.0); 8.0174 (0.5); 8.0020 (0.3); 7.7353 (1.0); 7.7159 (3.2); 7.6964 (3.9); 7.6874 (4.4); 7.6679 (1.3); 7.5737 (4.4); 7.5059 (2.7); 7.4868 (2.1); 7.4575 (5.0); 7.4364 (6.0); 7.3309 (6.6); 7.3254 (7.5); 7.2738 (3.8); 7.2683 (3.2); 7.2528 (3.1); 7.2473 (2.7); 3.9026 (3.8); 3.5662 (1.4); 3.5538 (5.4); 3.5419 (5.5); 3.5200 (1.2); 3.5024 (0.5); 3.3273 (189.8); 2.6758 (1.4); 2.6713 (1.8); 2.6668 (1.3); 2.5415 (1.3); 2.5246 (7.1); 2.5111 (124.7); 2.5068 (240.1); 2.5024 (305.1); 2.4978 (218.3); 2.4934 (106.6); 2.3336 (1.3); 2.3291 (1.8); 2.3246 (1.3); 1.4451 (1.2); 1.2587 (0.5); 1.2347 (0.9); 1.2134 (8.5); 1.1974 (8.5); -0.0002 (1.3)
I-076:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8055 (3.8); 8.8003 (2.6); 8.7906 (2.6); 8.7854 (3.8); 7.6537 (0.3); 7.6276 (1.8); 7.6073 (5.5); 7.6040 (4.5); 7.5868 (0.5); 7.5408 (2.4); 7.5281 (0.5); 7.5107 (1.1); 7.5015 (1.7); 7.4942 (1.1); 7.4802 (1.0); 7.4732 (0.6); 7.3619 (4.9); 7.3564 (3.1); 7.3472 (3.1); 7.3417 (4.9); 7.3166 (0.4); 7.2985 (24.7); 7.2380 (2.1); 7.2114 (2.5); 7.0425 (2.6); 6.9919 (1.8); 6.9652 (1.5); 6.9388 (1.2); 6.3845 (0.6); 6.3640 (1.1); 6.3442 (0.6); 4.0355 (1.2); 4.0150 (1.1); 3.9858 (2.5); 3.9653 (2.4); 3.9362 (1.3); 3.9155 (1.2); 3.6584 (4.1); 2.3930 (7.6); 2.3858 (4.4); 2.3633 (0.5); 2.3520 (0.4); 2.3135 (10.2); 1.6201 (16.0); 1.2921 (0.6); 0.0475 (0.8); 0.0367 (21.6); 0.0257 (0.8)
I-077:1 H-NMR(499.9 MHz, CDCl3): δ= 7.8886 (0.9); 7.8784 (1.3); 7.5633 (0.4); 7.5531 (0.4); 7.5359 (0.9); 7.5205 (2.1); 7.5050 (4.7); 7.4889 (0.9); 7.4594 (3.0); 7.3873 (1.8); 7.3731 (1.3); 7.2594 (8.4); 7.0891 (2.3); 7.0737 (2.6); 6.9596 (3.3); 6.8904 (1.8); 6.8753 (1.5); 4.1832 (8.2); 3.7709 (1.4); 3.7573 (3.1); 3.7449 (3.0); 3.7313 (1.2); 3.1916 (16.0); 3.0161 (0.4); 2.9468 (2.4); 2.9329 (4.3); 2.9188 (2.1); 2.3019 (14.8); 2.2812 (1.5); 2.2672 (14.1); 2.2410 (0.4); 2.2228 (0.4); 2.2172 (0.6); 2.0834 (0.5); 2.0233 (15.4); 2.0021 (1.4); 1.4148 (1.2); 1.2552 (0.7); 1.1080 (3.6); 0.9900 (0.4); -0.0002 (8.3)
I-078:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.0968 (1.4); 9.0854 (2.4); 9.0736 (1.3); 7.7752 (1.0); 7.7593 (2.3); 7.7429 (2.0); 7.7233 (3.3); 7.7081 (1.6); 7.5128 (5.6); 7.2891 (2.7); 7.2734 (2.8); 7.0235 (4.2); 6.7944 (2.4); 6.7788 (2.1); 4.4041 (0.4); 3.7558 (0.4); 3.5092 (16.0); 3.3192 (22.2); 2.5019 (26.1); 2.3838 (11.1); 2.1616 (13.7)
I-079:1 H-NMR(400.0 MHz, CD3CN): δ= 7.9732 (16.0); 7.9006 (0.4); 7.7317 (1.3); 7.7121 (4.2); 7.6926 (4.8); 7.6833 (5.4); 7.6638 (1.7); 7.5980 (1.3); 7.5828 (1.1); 7.5552 (5.4); 7.4883 (3.2); 7.4689 (2.5); 7.3770 (7.5); 7.3715 (7.7); 7.3134 (7.5); 7.2927 (8.3); 6.9383 (4.5); 6.9329 (4.4); 6.9176 (4.0); 6.9122 (3.9); 5.4454 (7.3); 4.0675 (0.5); 4.0497 (0.6); 3.6129 (7.7); 3.5974 (7.7); 2.1296 (8.6); 1.9711 (2.4); 1.9634 (1.0); 1.9574 (2.5); 1.9515 (13.4); 1.9454 (24.2); 1.9392 (32.4); 1.9330 (22.2); 1.9269 (11.4); 1.2681 (0.6); 1.2214 (0.6); 1.2036 (1.2); 1.1857 (0.6); 1.0891 (3.4); 1.0766 (10.2); 1.0731 (10.2); 1.0613 (4.3); 1.0241 (0.4); 0.9008 (0.4); 0.8803 (0.4); 0.8760 (0.4); 0.8632 (4.2); 0.8512 (10.0); 0.8480 (10.1); 0.8354 (3.3); 0.1459 (0.4); 0.0079 (2.8); -0.0002 (73.0); -0.0085 (2.8); -0.1497 (0.3)
I-080:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2612 (5.6); 8.0275 (0.8); 8.0161 (1.4); 7.4157 (1.4); 7.4115 (2.1); 7.3962 (4.5); 7.3909 (2.8); 7.3761 (1.6); 7.2622 (8.3); 7.2305 (1.5); 7.2194 (1.6); 7.2139 (2.1); 7.1985 (1.3); 7.1936 (1.2); 7.0804 (1.5); 7.0756 (2.4); 7.0708 (1.5); 6.9711 (1.2); 6.9665 (1.1); 6.9512 (1.1); 6.9464 (1.0); 6.0745 (0.5); 6.0667 (0.5); 6.0571 (0.5); 6.0492 (0.5); 5.9582 (0.5); 5.9504 (0.5); 5.9408 (0.5); 5.9330 (0.5); 4.2364 (0.3); 4.2279 (0.3); 4.2197 (0.4); 4.1780 (0.3); 4.1698 (0.3); 4.1614 (0.3); 3.8356 (0.4); 3.8311 (0.3); 3.8181 (0.3); 3.7946 (0.6); 3.7816 (0.6); 3.7641 (0.3); 2.9568 (6.7); 2.8836 (6.3); 2.5082 (16.0); 1.5752 (5.8); -0.0002 (2.3)
I-081:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6023 (0.5); 7.5761 (3.0); 7.5675 (2.5); 7.5635 (2.8); 7.5571 (8.0); 7.5538 (7.5); 7.5421 (0.6); 7.5379 (0.6); 7.4811 (3.6); 7.4606 (0.5); 7.4541 (0.4); 7.4455 (1.6); 7.4341 (2.3); 7.4272 (2.1); 7.4147 (1.6); 7.4070 (0.9); 7.3821 (3.5); 7.3554 (4.0); 7.2983 (16.5); 7.0825 (4.0); 7.0098 (2.2); 6.9836 (1.9); 6.7410 (2.6); 6.7018 (3.0); 6.6820 (3.3); 6.6428 (3.4); 6.4092 (1.0); 6.3894 (1.8); 6.3691 (1.0); 6.1084 (6.0); 6.0494 (5.0); 5.8475 (6.0); 5.8082 (5.5); 4.2481 (2.0); 4.2274 (1.8); 4.1990 (4.2); 4.1783 (3.9); 4.1498 (2.1); 4.1291 (2.0); 2.5062 (12.0); 2.4993 (6.8); 2.3918 (0.4); 2.3575 (0.3); 2.3235 (16.0); 1.6009 (12.3); 1.2921 (0.4); 0.0480 (0.5); 0.0373 (13.7); 0.0279 (0.4); 0.0264 (0.5)
I-082:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1835 (1.2); 9.1682 (2.5); 9.1527 (1.3); 8.2970 (11.6); 7.7924 (0.9); 7.7731 (2.8); 7.7536 (3.2); 7.7412 (3.9); 7.7108 (4.3); 7.6429 (2.5); 7.6233 (1.9); 7.3224 (3.5); 7.3024 (3.9); 7.0704 (4.3); 6.9036 (2.3); 6.8835 (2.2); 4.1667 (1.2); 4.1512 (1.2); 4.1300 (2.7); 4.1144 (2.7); 4.0932 (1.5); 4.0776 (1.4); 3.3012 (12.6); 2.5049 (9.3); 2.5005 (12.4); 2.4961 (9.2); 2.4216 (11.4); 2.2057 (16.0); 2.0715 (1.7); -0.0002 (4.1)
I-083:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5788 (0.8); 7.5735 (0.5); 7.5641 (1.2); 7.5613 (1.4); 7.5462 (0.9); 7.5173 (1.2); 7.4686 (0.7); 7.4497 (0.4); 7.4152 (0.4); 7.4003 (0.7); 7.3937 (1.5); 7.3647 (0.8); 7.2987 (2.8); 4.2126 (0.6); 4.1917 (0.6); 4.1652 (0.3); 2.7897 (1.3); 1.7460 (2.9); 1.6093 (16.0); 0.0326 (3.1)
I-084:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9551 (1.3); 8.9346 (1.3); 7.9562 (1.2); 7.7585 (6.3); 7.6933 (0.6); 7.6737 (1.7); 7.6565 (2.2); 7.6390 (2.2); 7.6308 (1.9); 7.6110 (0.8); 7.5671 (2.2); 7.5120 (1.2); 7.4920 (0.9); 7.3862 (1.9); 7.3656 (2.3); 7.2924 (4.3); 7.1282 (1.0); 7.1103 (1.7); 7.0922 (0.9); 7.0900 (1.0); 6.9004 (1.1); 6.8823 (1.9); 6.8631 (0.9); 5.4628 (0.7); 5.4447 (1.1); 5.4261 (0.8); 3.7143 (16.0); 3.3871 (126.0); 2.8954 (8.0); 2.7373 (7.1); 2.5910 (15.2); 2.5317 (0.3); 2.5269 (0.5); 2.5184 (7.5); 2.5140 (15.8); 2.5095 (21.3); 2.5050 (15.4); 2.5006 (7.4); 1.6015 (5.8); 1.5845 (5.7)
I-085:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5558 (2.7); 7.5512 (1.8); 7.5384 (4.0); 7.5248 (0.3); 7.4747 (1.9); 7.4280 (2.1); 7.4183 (1.8); 7.4120 (2.4); 7.4079 (2.1); 7.3999 (3.2); 7.3892 (0.9); 7.3823 (1.2); 7.3757 (1.0); 7.3666 (0.7); 7.3586 (0.5); 7.2986 (1.7); 7.2319 (2.0); 7.2254 (2.2); 7.2043 (2.3); 7.1975 (1.6); 7.1861 (0.6); 6.0481 (0.4); 6.0383 (0.5); 6.0246 (0.5); 6.0147 (0.5); 5.8927 (0.5); 5.8828 (0.5); 5.8692 (0.5); 5.8592 (0.5); 5.3306 (0.6); 4.1644 (0.4); 4.1408 (0.7); 4.1363 (0.4); 4.1258 (0.4); 4.1170 (0.9); 4.1046 (0.4); 4.0940 (0.6); 4.0727 (0.6); 4.0453 (0.4); 4.0350 (0.3); 4.0241 (0.4); 3.8956 (0.4); 3.8928 (0.4); 3.8723 (0.4); 3.8674 (0.3); 3.8433 (0.6); 3.8232 (0.6); 3.7994 (0.4); 3.7942 (0.3); 3.7709 (0.3); 2.3148 (16.0); 2.0630 (3.8); 1.3072 (0.9); 1.2894 (1.2); 1.2834 (1.9); 1.2596 (0.9); 0.9886 (0.3); 0.9642 (0.6); 0.0331 (1.4)
I-086:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2682 (10.5); 8.0280 (1.7); 8.0162 (3.3); 7.4785 (2.0); 7.4588 (4.5); 7.4390 (2.8); 7.4100 (3.3); 7.3895 (7.9); 7.2618 (20.2); 7.2372 (3.1); 7.2179 (2.6); 7.1961 (3.0); 7.1914 (2.7); 7.1753 (2.4); 7.1705 (2.4); 7.1290 (2.0); 7.1242 (2.6); 7.1039 (2.7); 7.0909 (4.4); 6.0772 (0.9); 6.0691 (1.1); 6.0598 (1.1); 6.0518 (1.0); 5.9610 (0.9); 5.9529 (1.1); 5.9434 (1.1); 5.9355 (1.0); 4.2866 (0.4); 4.2783 (0.5); 4.2697 (0.5); 4.2620 (0.5); 4.2500 (0.6); 4.2416 (0.6); 4.2331 (0.6); 4.2243 (0.7); 4.2124 (0.5); 4.2039 (0.5); 4.1959 (0.5); 4.1834 (0.6); 4.1752 (0.6); 4.1671 (0.6); 4.1590 (0.6); 3.8498 (0.4); 3.8358 (0.7); 3.8178 (0.6); 3.7989 (1.0); 3.7822 (1.0); 3.7643 (0.6); 3.7454 (0.6); 3.7289 (0.4); 2.9566 (16.0); 2.8834 (14.9); 2.8480 (0.9); 2.8277 (1.0); 2.8172 (1.5); 2.7967 (1.6); 2.7863 (1.1); 2.7659 (1.0); 1.9377 (0.6); 1.9252 (0.6); 1.9179 (0.7); 1.9068 (1.4); 1.8952 (1.1); 1.8877 (1.3); 1.8756 (1.5); 1.8653 (0.7); 1.8579 (0.7); 1.8453 (0.7); 1.6940 (0.5); 1.6844 (0.5); 1.6740 (0.9); 1.6638 (1.4); 1.6537 (1.0); 1.6434 (1.3); 1.6321 (1.0); 1.6236 (0.5); 1.6125 (0.5); 1.5701 (18.5); -0.0002 (5.8)
I-087:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2187 (2.0); 9.2033 (4.2); 9.1877 (2.0); 8.3169 (0.6); 7.9848 (16.0); 7.7582 (1.8); 7.7390 (4.7); 7.7167 (10.0); 7.7116 (9.5); 7.6856 (2.6); 7.6573 (6.6); 7.5723 (3.8); 7.5528 (3.1); 7.5139 (5.8); 7.4929 (6.9); 7.2984 (4.1); 7.2949 (4.0); 7.2779 (3.5); 7.2739 (3.4); 4.2910 (1.9); 4.2750 (2.1); 4.2556 (4.1); 4.2400 (4.0); 4.2207 (2.2); 4.2048 (2.2); 4.1893 (2.5); 4.1636 (6.8); 4.1380 (7.0); 4.1124 (2.4); 3.9029 (3.3); 3.3294 (262.4); 2.6757 (2.3); 2.6717 (2.9); 2.6676 (2.3); 2.5069 (404.2); 2.5027 (494.5); 2.4985 (369.1); 2.3338 (2.2); 2.3294 (2.8); 2.3253 (2.2); 1.2984 (0.4); 1.2670 (0.4); 1.2581 (0.6); 1.2355 (1.0); 0.8616 (0.5); 0.8432 (0.5); -0.0002 (1.6)
I-088:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3739 (3.2); 9.3544 (3.2); 8.6198 (16.0); 7.9592 (1.2); 7.7928 (1.5); 7.7747 (9.2); 7.7621 (6.6); 7.7543 (8.1); 7.7469 (8.1); 7.7298 (4.6); 7.6864 (3.5); 7.6675 (2.2); 7.6050 (1.9); 7.5853 (4.6); 7.5703 (3.7); 7.5517 (3.7); 7.5326 (1.2); 5.2991 (0.5); 5.2812 (1.9); 5.2632 (2.8); 5.2449 (1.9); 5.2264 (0.5); 3.3184 (59.9); 2.8967 (7.6); 2.7377 (6.6); 2.6806 (0.6); 2.6763 (0.8); 2.6716 (0.6); 2.5116 (98.7); 2.5072 (127.6); 2.5029 (91.6); 2.3387 (0.6); 2.3340 (0.8); 2.3296 (0.5); 1.5060 (13.2); 1.4884 (13.0)
I-089:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1049 (0.8); 8.0869 (1.5); 8.0692 (0.9); 7.8663 (10.5); 7.6212 (0.6); 7.5953 (2.5); 7.5720 (7.4); 7.5489 (0.7); 7.4607 (3.6); 7.4261 (1.5); 7.4179 (2.5); 7.4105 (1.3); 7.3954 (1.6); 7.3553 (3.5); 7.3287 (4.0); 7.3046 (15.6); 7.0698 (3.9); 6.9752 (2.1); 6.9488 (1.8); 5.4528 (2.6); 4.2978 (1.8); 4.2779 (1.8); 4.2498 (3.9); 4.2299 (3.8); 4.2018 (2.0); 4.1819 (1.8); 2.6877 (0.7); 2.6725 (1.1); 2.6657 (1.4); 2.6614 (1.4); 2.6540 (1.2); 2.6439 (0.8); 2.6323 (0.4); 2.5152 (11.5); 2.5081 (6.5); 2.3200 (16.0); 1.6668 (1.1); 1.2985 (1.1); 0.9426 (1.0); 0.9246 (3.3); 0.9197 (4.0); 0.9031 (4.3); 0.8975 (3.4); 0.8811 (1.3); 0.6604 (1.2); 0.6447 (3.4); 0.6375 (4.1); 0.6267 (3.3); 0.6097 (1.0); 0.1141 (0.4); 0.0543 (0.5); 0.0436 (15.3); 0.0327 (0.6)
I-090:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5678 (9.0); 7.9182 (0.7); 7.9009 (1.1); 7.8848 (0.6); 7.6785 (6.4); 7.6618 (5.6); 7.5315 (2.6); 7.5088 (1.5); 7.4806 (5.5); 7.4635 (4.1); 7.4583 (3.5); 7.4476 (1.8); 7.4409 (1.6); 7.4310 (1.8); 7.2994 (29.5); 4.4860 (1.4); 4.4654 (1.5); 4.4375 (3.1); 4.4171 (3.0); 4.3891 (1.6); 4.3686 (1.5); 4.1728 (0.3); 4.1488 (0.4); 2.0841 (1.5); 1.5788 (16.0); 1.3222 (1.2); 1.3058 (3.1); 1.2987 (3.4); 1.2749 (0.7); 0.9429 (1.0); 0.9212 (3.2); 0.8979 (1.2); 0.0497 (1.0); 0.0390 (28.5); 0.0282 (1.3)
I-091:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2543 (1.4); 9.2351 (1.5); 7.8131 (6.2); 7.7246 (0.6); 7.7048 (1.7); 7.6856 (1.5); 7.6587 (1.3); 7.6442 (2.8); 7.6369 (7.5); 7.6279 (9.2); 7.6065 (1.3); 7.5728 (1.4); 7.5517 (1.1); 5.2156 (0.8); 5.1977 (1.2); 5.1796 (0.8); 3.3806 (61.2); 2.8934 (1.1); 2.7350 (1.0); 2.6169 (16.0); 2.5172 (5.7); 2.5128 (12.3); 2.5083 (16.7); 2.5038 (12.2); 2.4994 (6.0); 1.4706 (6.2); 1.4530 (6.2)
I-092:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5933 (3.5); 7.5728 (3.8); 7.5697 (3.2); 7.5575 (0.3); 7.5521 (0.3); 7.4972 (1.7); 7.4363 (0.7); 7.4268 (1.4); 7.4192 (0.9); 7.4133 (0.6); 7.4005 (3.0); 7.3951 (3.3); 7.3898 (3.8); 7.3619 (0.5); 7.2986 (7.5); 6.6149 (0.4); 6.5947 (0.8); 6.5751 (0.4); 6.0797 (0.5); 6.0694 (0.5); 6.0560 (0.5); 6.0459 (0.5); 5.9241 (0.5); 5.9140 (0.5); 5.9005 (0.5); 5.8902 (0.5); 5.3367 (3.6); 4.2267 (0.3); 4.2164 (0.3); 4.2046 (0.3); 4.1943 (0.4); 4.1858 (0.8); 4.1622 (1.9); 4.1382 (1.9); 4.1259 (0.4); 4.1146 (1.1); 4.1039 (0.4); 4.0931 (0.5); 3.9309 (0.4); 3.9269 (0.4); 3.9074 (0.4); 3.8778 (0.6); 3.8583 (0.6); 3.8347 (0.4); 3.8288 (0.4); 2.4220 (16.0); 2.0777 (9.1); 2.0401 (0.4); 1.6210 (3.1); 1.3171 (2.1); 1.2932 (4.8); 1.2694 (2.1); 0.9947 (0.4); 0.9702 (0.8); 0.9458 (0.3); 0.1062 (0.4); 0.0356 (6.6)
I-093:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5525 (0.4); 7.5262 (1.4); 7.5047 (4.2); 7.4832 (0.4); 7.4133 (3.8); 7.3868 (2.2); 7.3668 (0.9); 7.3578 (1.4); 7.3505 (0.9); 7.3432 (0.6); 7.3365 (0.9); 7.2983 (12.0); 7.1082 (2.2); 7.0500 (1.2); 7.0224 (1.0); 6.6085 (0.6); 6.5880 (1.1); 6.5680 (0.6); 4.8218 (0.3); 4.7868 (16.0); 4.5734 (11.3); 4.2706 (0.9); 4.2497 (0.8); 4.2211 (1.8); 4.2001 (1.7); 4.1715 (0.9); 4.1506 (0.9); 2.5347 (6.3); 2.3648 (8.4); 2.0422 (0.7); 1.6009 (4.7); 0.1074 (0.9); 0.0482 (0.5); 0.0376 (11.7); 0.0267 (0.5)
I-094:1 H-NMR(300.2 MHz, CDCl3): δ= 9.1323 (0.4); 8.3939 (4.9); 7.6216 (0.4); 7.6175 (0.4); 7.6060 (3.6); 7.6025 (3.4); 7.5951 (1.5); 7.5905 (1.6); 7.5847 (1.8); 7.3479 (1.6); 7.2985 (6.0); 7.2863 (0.8); 7.2774 (0.9); 7.2655 (1.0); 7.2589 (0.9); 7.2478 (0.5); 7.0267 (1.7); 7.0012 (2.0); 6.9123 (1.9); 6.7390 (1.1); 6.7134 (0.9); 4.2143 (1.1); 4.1931 (2.0); 4.1750 (1.9); 4.1523 (1.1); 3.1164 (1.7); 3.0940 (2.8); 3.0719 (1.5); 2.7454 (1.0); 2.7349 (16.0); 2.3162 (10.9); 2.1973 (10.0); 1.5963 (1.4); 1.2950 (1.1); 0.0393 (6.1)
I-095:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 11.8389 (1.6); 7.9539 (0.6); 7.8445 (5.6); 7.7185 (0.7); 7.6988 (2.0); 7.6793 (2.9); 7.6581 (8.4); 7.6506 (8.5); 7.6344 (1.6); 7.6293 (1.6); 7.5596 (2.4); 7.5227 (1.4); 7.5030 (1.1); 5.0568 (6.6); 3.3361 (28.8); 2.8932 (3.7); 2.7347 (3.3); 2.5975 (16.0); 2.5755 (0.5); 2.5090 (24.6); 2.5046 (31.1); 2.5002 (22.7); 1.2412 (1.0); -0.0002 (1.0)
I-096:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9961 (5.0); 7.9874 (5.1); 7.8491 (5.0); 7.8435 (5.1); 7.6422 (0.4); 7.6158 (3.1); 7.6105 (2.8); 7.6057 (2.8); 7.5979 (7.6); 7.5949 (7.2); 7.4827 (3.9); 7.4627 (1.7); 7.4506 (2.1); 7.4437 (1.7); 7.4324 (1.5); 7.4244 (0.9); 7.3350 (3.4); 7.3048 (16.9); 7.0486 (4.1); 6.9415 (2.2); 6.9143 (2.0); 6.8446 (1.0); 6.8247 (1.8); 6.8039 (1.0); 6.6312 (3.4); 6.6249 (4.5); 6.6164 (3.2); 4.1403 (1.8); 4.1198 (1.7); 4.0918 (3.8); 4.0711 (3.6); 4.0431 (1.9); 4.0225 (1.8); 2.4671 (11.7); 2.3471 (0.5); 2.2917 (16.0); 1.6327 (11.0); 1.3108 (2.2); 0.9483 (0.8); 0.9267 (2.2); 0.9034 (0.9); 0.1151 (0.7); 0.0553 (0.6); 0.0446 (14.4); 0.0338 (0.5)
I-097:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0618 (2.2); 9.0441 (2.2); 8.1378 (10.9); 7.7311 (0.8); 7.7120 (2.7); 7.6925 (3.0); 7.6803 (3.7); 7.6581 (4.7); 7.6404 (0.6); 7.5721 (2.3); 7.5522 (1.8); 7.4422 (4.2); 7.3385 (2.0); 7.3345 (1.8); 7.3183 (2.6); 7.3145 (2.5); 7.2073 (3.6); 7.1872 (2.7); 4.6964 (0.7); 4.6835 (1.4); 4.6650 (1.5); 4.6518 (0.8); 3.3217 (17.8); 3.3087 (1.5); 3.2861 (1.7); 3.2682 (2.7); 3.2501 (1.4); 3.2281 (1.7); 3.2097 (1.5); 2.9322 (1.5); 2.9198 (1.5); 2.8910 (1.3); 2.8762 (2.3); 2.8620 (1.6); 2.8336 (1.3); 2.8211 (1.3); 2.6711 (0.5); 2.5060 (70.2); 2.5017 (90.4); 2.4974 (65.2); 2.3330 (0.4); 2.3285 (0.5); 1.3973 (16.0); -0.0002 (8.0)
I-098:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2571 (1.3); 9.2379 (1.3); 7.8122 (6.2); 7.7250 (0.6); 7.7058 (1.7); 7.6859 (1.5); 7.6590 (1.3); 7.6446 (2.7); 7.6371 (7.3); 7.6280 (8.9); 7.6064 (1.2); 7.5729 (1.4); 7.5513 (1.0); 5.2151 (0.8); 5.1969 (1.3); 5.1789 (0.8); 3.3912 (80.6); 2.8944 (1.0); 2.7361 (0.9); 2.6170 (16.0); 2.5312 (0.3); 2.5180 (6.5); 2.5137 (13.5); 2.5092 (18.0); 2.5047 (13.0); 2.5004 (6.3); 1.4705 (6.3); 1.4529 (6.2)
I-099:1 H-NMR(400.0 MHz, CD3CN): δ= 8.2376 (7.4); 8.1332 (2.0); 8.0852 (16.0); 8.0124 (0.4); 7.7135 (1.3); 7.6937 (5.2); 7.6763 (14.2); 7.6611 (1.4); 7.6227 (2.4); 7.6026 (6.2); 7.5817 (10.2); 7.5616 (3.7); 7.5094 (7.4); 7.4747 (0.4); 7.4543 (4.4); 7.4372 (3.4); 4.3735 (3.8); 4.3577 (3.9); 4.3397 (8.0); 4.3239 (7.8); 4.3060 (4.1); 4.2902 (3.9); 2.3860 (0.6); 2.2210 (32.4); 2.1301 (7.2); 1.9512 (16.2); 1.9452 (28.6); 1.9391 (37.7); 1.9330 (26.6); 1.9269 (14.0); 1.2846 (0.4); 1.2684 (1.0); 0.1460 (0.4); -0.0002 (80.7); -0.1497 (0.4)
I-100:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0114 (2.3); 7.6271 (0.6); 7.6161 (0.4); 7.5971 (1.8); 7.5852 (2.6); 7.5429 (0.3); 7.4915 (0.4); 7.4717 (2.1); 7.4501 (3.9); 7.4050 (3.8); 7.3838 (2.1); 7.3608 (1.1); 7.3453 (0.7); 7.3403 (0.7); 7.2784 (0.7); 7.2604 (25.4); 4.1834 (0.7); 4.1683 (0.7); 4.1477 (1.4); 4.1327 (1.4); 4.1120 (0.8); 4.0972 (0.8); 2.9550 (16.0); 2.8800 (14.9); 1.5752 (1.2); 1.5031 (0.6); -0.0002 (7.3)
I-101:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1350 (5.2); 8.0915 (0.5); 8.0738 (0.8); 8.0544 (0.5); 7.6381 (0.7); 7.6119 (1.8); 7.5855 (1.3); 7.5176 (3.9); 7.4888 (4.9); 7.4202 (4.2); 7.3978 (2.4); 7.3929 (2.5); 7.3678 (1.1); 7.3649 (1.2); 7.3412 (0.9); 7.3381 (1.0); 7.3342 (0.8); 7.3042 (3.0); 6.9240 (1.1); 6.7363 (2.3); 6.5487 (1.2); 4.2744 (1.1); 4.2542 (1.1); 4.2273 (2.3); 4.2070 (2.2); 4.1802 (1.2); 4.1599 (1.1); 2.7630 (16.0); 1.6462 (0.5); 1.2986 (1.1); 0.0416 (2.9)
I-102:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1299 (1.5); 9.1090 (1.5); 7.9529 (1.4); 7.9032 (6.4); 7.7318 (0.6); 7.7121 (1.6); 7.6930 (1.4); 7.6542 (1.8); 7.6335 (3.2); 7.5967 (1.3); 7.5746 (1.0); 7.2780 (1.9); 7.2534 (2.0); 6.9939 (3.0); 6.9777 (3.0); 5.2970 (0.4); 5.2785 (0.5); 5.2692 (0.5); 5.2600 (0.5); 5.2503 (0.5); 5.2320 (0.4); 3.3299 (38.6); 2.8928 (10.3); 2.7336 (8.9); 2.6292 (16.0); 2.5260 (0.6); 2.5212 (1.0); 2.5126 (13.9); 2.5082 (28.3); 2.5037 (37.1); 2.4991 (26.6); 2.4946 (12.8); 2.1696 (0.8); 2.1538 (0.9); 2.1363 (1.1); 2.1207 (1.0); 1.8413 (0.9); 1.8123 (1.1); 1.7797 (0.8); 1.3882 (10.6); 1.2957 (10.4); 1.2404 (0.8)
I-103:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2346 (6.4); 8.1430 (0.9); 7.3331 (2.1); 7.3131 (2.4); 7.2602 (9.2); 7.1428 (2.0); 7.1230 (2.5); 7.0342 (2.5); 6.9938 (1.6); 6.9888 (1.7); 6.9741 (1.3); 6.9690 (1.5); 6.9590 (1.4); 6.9389 (1.3); 6.9150 (2.8); 6.9108 (2.4); 4.2337 (1.0); 4.2188 (1.0); 4.1976 (2.2); 4.1827 (2.2); 4.1614 (1.2); 4.1465 (1.1); 3.2133 (16.0); 2.9563 (2.3); 2.8838 (2.1); 2.4694 (7.1); 2.2947 (10.0); 1.5623 (6.1); -0.0002 (2.6)
I-104:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2664 (0.3); 7.9976 (1.5); 7.5582 (1.5); 7.5385 (6.2); 7.5226 (16.0); 7.5051 (11.0); 7.4834 (14.0); 7.4552 (0.6); 7.4337 (0.8); 7.4056 (8.0); 7.3842 (13.4); 7.3628 (9.9); 7.3508 (3.4); 7.3441 (5.2); 7.3387 (3.6); 7.3336 (2.4); 7.3275 (3.6); 7.3222 (2.3); 7.2599 (117.9); 6.9960 (0.6); 6.3158 (2.0); 6.3002 (3.5); 6.2852 (1.9); 4.2229 (3.6); 4.2073 (3.6); 4.1863 (7.8); 4.1707 (7.4); 4.1497 (4.0); 4.1341 (3.7); 4.0036 (2.7); 2.9511 (11.2); 2.8722 (10.0); 1.9601 (1.1); 1.9454 (2.5); 1.9383 (2.5); 1.9308 (1.7); 1.9237 (4.9); 1.9167 (1.7); 1.9090 (2.7); 1.9020 (2.7); 1.8873 (1.3); 1.5433 (160.8); 1.5032 (0.6); 1.2722 (0.4); 1.2653 (0.4); 1.2596 (0.5); 1.2530 (0.6); 1.1783 (0.3); 1.1645 (2.2); 1.1504 (6.7); 1.1480 (7.6); 1.1446 (5.4); 1.1345 (3.9); 1.1291 (7.3); 1.1264 (7.1); 1.1133 (2.9); 1.0980 (0.5); 1.0922 (0.4); 1.0828 (0.5); 1.0765 (0.7); 1.0628 (0.4); 1.0560 (0.4); 0.9851 (0.4); 0.9695 (0.4); 0.9474 (3.0); 0.9324 (9.2); 0.9178 (8.6); 0.9040 (2.0); 0.7916 (0.4); 0.7794 (0.4); 0.0079 (1.6); -0.0002 (34.5); -0.0084 (1.8)
I-105:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1263 (0.3); 7.7723 (0.4); 7.7604 (3.0); 7.6086 (0.6); 7.5835 (1.4); 7.5783 (1.8); 7.5736 (1.9); 7.4891 (0.8); 7.4370 (0.4); 7.4308 (0.6); 7.4238 (0.4); 7.4096 (0.6); 7.4055 (0.6); 7.3823 (1.2); 7.3768 (1.3); 7.3676 (1.7); 7.3400 (0.3); 7.2986 (5.6); 3.8095 (0.3); 3.2100 (16.0); 0.1065 (0.6); 0.0364 (4.4)
I-106:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9558 (2.5); 8.9494 (2.6); 7.9244 (2.7); 7.9180 (2.6); 7.5996 (1.0); 7.5785 (3.2); 7.5157 (1.5); 7.4831 (0.7); 7.4741 (1.1); 7.4669 (0.7); 7.4603 (0.4); 7.4518 (0.6); 7.4451 (0.4); 7.2988 (14.9); 7.2761 (1.6); 7.0473 (1.6); 6.9634 (0.8); 6.9365 (0.7); 6.5245 (0.4); 6.5045 (0.7); 6.4841 (0.4); 5.3381 (0.3); 4.1064 (0.7); 4.0857 (0.7); 4.0570 (1.6); 4.0363 (1.5); 4.0075 (0.8); 3.9869 (0.8); 2.4480 (4.6); 2.4408 (2.6); 2.3000 (6.2); 2.2757 (0.3); 1.6109 (16.0); 0.0487 (0.5); 0.0378 (13.2); 0.0268 (0.5)
I-107:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1235 (1.4); 9.1030 (1.4); 7.8225 (6.6); 7.7165 (0.5); 7.6963 (1.6); 7.6775 (1.3); 7.6363 (1.8); 7.6185 (3.5); 7.5731 (1.3); 7.5511 (1.1); 7.1053 (1.4); 7.0872 (1.5); 7.0324 (1.3); 7.0144 (1.5); 6.7283 (1.6); 6.7095 (2.7); 6.6908 (1.3); 5.2492 (0.4); 5.2339 (0.9); 5.2148 (0.9); 5.1994 (0.4); 4.2834 (0.9); 4.2748 (0.8); 4.2655 (1.2); 4.2541 (1.2); 4.2430 (0.8); 4.2346 (1.0); 4.2150 (0.3); 3.3329 (33.2); 2.6052 (16.0); 2.5250 (0.5); 2.5203 (0.7); 2.5116 (9.0); 2.5072 (18.5); 2.5027 (24.4); 2.4981 (17.7); 2.4937 (8.6); 2.1630 (0.4); 2.1600 (0.4); 2.1481 (0.5); 2.1397 (0.6); 2.1339 (0.5); 2.1279 (0.6); 2.1146 (0.7); 2.1029 (12.0); 2.0125 (0.4); 2.0034 (0.6); 1.9956 (0.7); 1.9864 (0.5); 1.9780 (0.6); 1.9693 (0.4); 1.9610 (0.4); 1.2406 (0.4)
I-108:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1047 (1.5); 9.0894 (3.0); 9.0734 (1.4); 8.7025 (4.9); 8.6969 (4.8); 8.3163 (0.5); 8.0824 (16.0); 7.9229 (3.0); 7.9169 (3.0); 7.9018 (3.8); 7.8958 (3.7); 7.7473 (1.1); 7.7281 (3.6); 7.7100 (8.9); 7.6969 (4.8); 7.6903 (6.0); 7.6773 (1.6); 7.6163 (4.8); 7.5487 (2.7); 7.5291 (2.1); 4.2781 (1.5); 4.2625 (1.5); 4.2428 (3.4); 4.2270 (3.3); 4.2071 (1.7); 4.1915 (1.6); 3.9028 (0.8); 3.3274 (168.0); 2.6758 (1.3); 2.6713 (1.8); 2.6667 (1.3); 2.5415 (1.3); 2.5246 (7.2); 2.5112 (122.4); 2.5068 (235.1); 2.5023 (298.1); 2.4978 (213.9); 2.4934 (104.7); 2.3336 (1.3); 2.3291 (1.8); 2.3247 (1.3); 1.2357 (0.4); -0.0002 (1.3)
I-109:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2829 (9.4); 7.6427 (0.9); 7.6167 (2.4); 7.5997 (1.9); 7.5736 (2.2); 7.5475 (0.8); 7.3016 (14.6); 7.2108 (0.8); 7.1949 (0.8); 7.1468 (2.5); 7.0389 (1.4); 7.0214 (2.7); 7.0132 (1.5); 6.9966 (2.7); 6.7785 (1.6); 6.7527 (1.4); 6.7064 (2.9); 3.6600 (0.5); 3.6468 (0.6); 3.6413 (0.6); 3.6353 (0.8); 3.6281 (0.7); 3.6201 (0.9); 3.6171 (0.9); 3.6097 (0.7); 3.6022 (0.8); 3.5963 (0.6); 3.5910 (0.6); 3.5777 (0.4); 2.4036 (0.5); 2.3752 (1.5); 2.3501 (1.5); 2.3336 (16.0); 2.0495 (0.5); 1.9991 (14.8); 1.5986 (7.0); 1.5716 (1.0); 1.5506 (1.4); 1.5418 (1.0); 1.5270 (1.2); 1.5208 (1.3); 1.5182 (1.2); 1.4972 (0.9); 1.2027 (0.9); 1.1897 (1.0); 1.1806 (1.4); 1.1674 (1.3); 1.1587 (0.9); 1.1457 (0.8); 0.0512 (0.5); 0.0403 (14.6); 0.0294 (0.5)
I-110:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2787 (1.2); 9.2633 (2.7); 9.2476 (1.4); 7.8781 (6.6); 7.8031 (0.8); 7.7839 (2.4); 7.7632 (2.3); 7.7422 (3.6); 7.7228 (1.7); 7.6010 (7.8); 7.5846 (2.3); 7.3860 (4.2); 7.3829 (6.7); 7.3797 (4.2); 7.1959 (3.5); 7.1759 (4.1); 7.1641 (6.3); 7.0439 (4.4); 6.8587 (2.4); 6.8393 (2.2); 5.7502 (9.8); 4.0205 (1.2); 4.0043 (1.2); 3.9831 (2.6); 3.9675 (2.5); 3.9458 (1.4); 3.9302 (1.3); 3.3007 (32.3); 2.5043 (13.8); 2.4999 (18.8); 2.4955 (14.1); 2.3428 (11.6); 2.1972 (16.0); 2.1618 (0.4); 1.9872 (0.4); 1.2358 (0.5); 1.1748 (0.3); 0.0080 (0.4); -0.0002 (11.4)
I-111:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1076 (0.4); 7.7211 (3.1); 7.5944 (0.7); 7.5694 (1.7); 7.4914 (1.1); 7.4624 (2.6); 7.4006 (2.3); 7.3732 (1.2); 7.2983 (1.2); 4.2537 (0.5); 4.2334 (0.5); 4.2069 (1.0); 4.1866 (1.0); 4.1600 (0.5); 4.1398 (0.5); 3.2051 (16.0); 3.0767 (0.5); 0.0339 (1.0)
I-112:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0776 (0.7); 9.0620 (1.4); 9.0458 (0.7); 8.3097 (3.3); 7.8519 (0.3); 7.7379 (0.6); 7.7187 (1.8); 7.6990 (1.6); 7.6821 (0.4); 7.6693 (1.9); 7.6581 (6.4); 7.6502 (1.3); 7.5865 (2.4); 7.5447 (0.3); 7.5312 (1.4); 7.5152 (3.1); 7.4948 (2.5); 7.4304 (2.7); 7.1159 (1.3); 7.0957 (1.2); 4.2724 (0.6); 4.2577 (0.7); 4.2378 (1.4); 4.2221 (1.4); 4.2025 (0.7); 4.1871 (0.7); 3.9296 (1.2); 3.9240 (1.4); 3.9049 (1.3); 3.8970 (1.8); 3.4101 (1.4); 3.4011 (1.3); 3.3823 (2.4); 3.3744 (2.4); 3.3239 (957.9); 2.7594 (0.4); 2.7442 (0.6); 2.7326 (0.8); 2.7117 (1.0); 2.6899 (1.1); 2.6805 (1.6); 2.6760 (3.2); 2.6714 (4.4); 2.6668 (3.1); 2.6623 (1.5); 2.6279 (0.3); 2.5912 (2.3); 2.5799 (16.0); 2.5416 (166.2); 2.5248 (13.7); 2.5200 (20.7); 2.5114 (264.0); 2.5070 (519.0); 2.5024 (672.3); 2.4979 (482.6); 2.4934 (231.0); 2.3683 (0.6); 2.3384 (1.4); 2.3338 (3.1); 2.3293 (4.2); 2.3248 (3.0); 2.3203 (1.4); 2.2950 (1.1); 1.5955 (2.1); 1.5878 (2.2); 1.5732 (3.0); 1.5633 (2.0); 1.5455 (0.7); 1.5347 (0.8); 1.2601 (0.4); 1.2460 (0.5); 1.2352 (0.5); -0.0002 (6.2)
I-113:1 H-NMR(400.0 MHz, CD3CN): δ= 8.3305 (6.6); 8.3262 (7.3); 8.1733 (1.9); 8.1489 (7.7); 8.1445 (7.6); 8.0917 (16.0); 8.0076 (0.4); 7.7130 (1.2); 7.6933 (4.5); 7.6751 (12.4); 7.6578 (1.3); 7.5175 (6.2); 7.4795 (0.3); 7.4632 (2.3); 7.4579 (4.0); 7.4530 (2.5); 7.4403 (2.9); 5.4456 (0.4); 4.4402 (3.4); 4.4239 (3.5); 4.4072 (7.2); 4.3909 (7.1); 4.3742 (3.7); 4.3579 (3.6); 4.0854 (0.3); 4.0677 (1.0); 4.0498 (1.0); 4.0320 (0.3); 2.1297 (19.9); 2.1068 (0.3); 1.9713 (4.3); 1.9636 (1.5); 1.9575 (3.5); 1.9517 (18.3); 1.9455 (33.3); 1.9394 (44.8); 1.9332 (31.4); 1.9271 (16.6); 1.2676 (0.7); 1.2215 (1.1); 1.2037 (2.2); 1.1859 (1.1); 0.1457 (0.5); 0.0077 (4.3); -0.0002 (104.0); -0.0083 (5.3); -0.1499 (0.5)
I-114:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5875 (0.5); 7.5613 (3.0); 7.5536 (2.7); 7.5488 (3.0); 7.5426 (7.8); 7.5394 (7.6); 7.4580 (3.6); 7.4349 (0.6); 7.4282 (0.5); 7.4196 (1.6); 7.4084 (2.4); 7.3982 (4.6); 7.3894 (1.9); 7.3806 (1.2); 7.3715 (4.1); 7.2986 (12.4); 7.0848 (4.0); 7.0045 (2.2); 6.9782 (1.9); 6.5072 (1.0); 6.4873 (1.9); 6.4672 (1.0); 4.2891 (1.8); 4.2687 (1.8); 4.2394 (3.9); 4.2190 (3.7); 4.1897 (2.0); 4.1693 (1.9); 2.5186 (12.0); 2.5119 (6.9); 2.3567 (0.4); 2.3218 (16.0); 2.0392 (1.0); 1.9886 (0.6); 1.9689 (1.2); 1.9595 (1.2); 1.9495 (0.8); 1.9401 (2.5); 1.9308 (0.8); 1.9204 (1.3); 1.9111 (1.4); 1.8916 (0.7); 1.6081 (12.4); 1.4517 (0.6); 1.4307 (0.6); 1.2927 (5.1); 1.2177 (0.3); 1.1934 (1.2); 1.1766 (3.2); 1.1705 (3.9); 1.1658 (2.9); 1.1532 (2.0); 1.1469 (3.4); 1.1421 (3.4); 1.1249 (1.6); 1.1044 (0.4); 0.9935 (1.7); 0.9739 (4.4); 0.9545 (4.2); 0.9355 (1.2); 0.9179 (0.5); 0.9091 (0.4); 0.8942 (0.5); 0.8676 (0.3); 0.0483 (0.4); 0.0376 (11.4); 0.0266 (0.5)
I-115:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5944 (0.4); 7.5656 (4.4); 7.5605 (3.3); 7.5483 (7.4); 7.4517 (3.8); 7.4247 (0.6); 7.4110 (1.7); 7.3908 (5.2); 7.3818 (1.8); 7.3641 (4.3); 7.2986 (8.7); 7.1072 (4.2); 7.0352 (2.3); 7.0087 (1.9); 6.8275 (1.0); 6.8070 (1.9); 6.7866 (1.0); 5.3988 (0.6); 5.3819 (1.7); 5.3627 (2.9); 5.3459 (2.0); 5.3270 (0.7); 4.8806 (1.6); 4.8531 (6.9); 4.8361 (9.2); 4.8224 (6.7); 4.8120 (1.9); 4.7955 (1.1); 4.2476 (1.6); 4.2269 (1.6); 4.1983 (3.4); 4.1776 (3.4); 4.1539 (1.2); 4.1489 (1.8); 4.1290 (1.8); 2.9674 (0.4); 2.8545 (0.3); 2.5190 (11.8); 2.5125 (7.1); 2.3724 (0.8); 2.3460 (16.0); 2.3052 (0.3); 2.0727 (2.5); 1.3150 (0.9); 1.2916 (2.8); 1.2674 (0.9); 0.3055 (0.4); 0.1938 (0.5); 0.1760 (1.1); 0.1223 (4.6); 0.1104 (100.1); 0.0982 (4.9); 0.0385 (7.4); 0.0276 (0.4); -0.0876 (0.4)
I-116:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0741 (1.4); 9.0547 (1.4); 7.7418 (0.6); 7.7204 (7.1); 7.7025 (1.5); 7.6826 (1.8); 7.6628 (0.8); 7.6192 (2.1); 7.5188 (1.1); 7.4988 (0.9); 7.2622 (3.4); 7.2412 (4.2); 7.0720 (0.5); 7.0656 (4.6); 7.0610 (1.5); 7.0446 (3.8); 5.7574 (0.3); 4.7742 (0.5); 4.7624 (0.6); 4.7545 (0.6); 4.7498 (0.7); 4.7431 (0.7); 4.7382 (0.6); 4.7302 (0.6); 4.7185 (0.5); 3.6840 (16.0); 3.3323 (111.8); 3.3055 (0.3); 3.1983 (0.7); 3.1865 (0.7); 3.1635 (1.0); 3.1519 (0.9); 3.0322 (1.0); 3.0075 (1.0); 2.9975 (0.8); 2.9730 (0.7); 2.6710 (0.3); 2.5969 (14.7); 2.5245 (0.9); 2.5111 (20.8); 2.5067 (42.9); 2.5022 (56.8); 2.4977 (41.3); 2.4932 (20.3); 2.3289 (0.3); -0.0002 (0.4)
I-117:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0548 (1.5); 9.0345 (1.5); 7.7689 (5.9); 7.7295 (0.7); 7.7096 (1.9); 7.6904 (1.5); 7.6566 (4.3); 7.6359 (1.1); 7.5817 (1.5); 7.5621 (1.1); 7.0772 (1.4); 7.0550 (3.9); 6.9489 (2.3); 6.9297 (1.7); 5.0681 (0.8); 5.0496 (1.2); 5.0313 (0.8); 3.3537 (40.0); 3.3502 (40.8); 2.8903 (2.0); 2.7316 (1.8); 2.6495 (1.3); 2.6362 (2.6); 2.6209 (1.5); 2.6009 (16.0); 2.5735 (0.4); 2.5462 (0.6); 2.5259 (1.6); 2.5118 (9.8); 2.5077 (19.0); 2.5032 (25.0); 2.4988 (18.5); 2.4945 (9.5); 2.4686 (0.3); 1.6631 (3.4); 1.6558 (2.9); 1.6483 (3.4); 1.6188 (0.5); 1.4062 (6.2); 1.3887 (6.2); 1.2402 (0.4)
I-118:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2244 (1.5); 9.2035 (1.5); 7.9224 (0.4); 7.8490 (6.6); 7.7213 (0.6); 7.7010 (1.7); 7.6805 (1.4); 7.6548 (0.4); 7.6413 (2.0); 7.6256 (3.2); 7.6235 (3.2); 7.5871 (1.4); 7.5649 (1.1); 7.1938 (1.1); 7.1868 (1.2); 7.1667 (2.0); 7.1627 (1.4); 7.1524 (1.4); 7.1445 (1.8); 7.1306 (1.7); 7.0451 (0.9); 7.0380 (0.8); 7.0241 (1.4); 7.0170 (1.2); 7.0026 (0.6); 6.9955 (0.6); 5.2416 (0.4); 5.2220 (0.8); 5.2103 (0.8); 5.2028 (0.6); 5.1908 (0.4); 3.3376 (58.8); 3.1596 (0.3); 3.1497 (0.4); 3.1376 (0.9); 3.1277 (0.8); 3.1179 (0.8); 3.1074 (0.7); 3.0969 (0.7); 3.0869 (0.8); 3.0768 (0.8); 3.0670 (0.9); 3.0552 (0.4); 3.0448 (0.3); 2.6323 (1.2); 2.6140 (16.0); 2.5257 (0.6); 2.5210 (0.8); 2.5121 (10.9); 2.5078 (22.2); 2.5033 (29.4); 2.4988 (21.5); 2.4944 (10.6); 2.2080 (0.6); 2.1971 (0.8); 2.1872 (0.8); 2.1774 (1.0); 2.1672 (0.8); 2.1576 (0.8); 2.1477 (0.8); 2.1383 (0.4); 2.1285 (0.5); 1.2398 (0.4)
I-119:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5359 (0.3); 7.5190 (3.0); 7.5092 (4.4); 7.4104 (2.4); 7.3383 (0.8); 7.3302 (1.2); 7.3271 (1.1); 7.3209 (0.9); 7.2579 (2.9); 7.0067 (1.9); 6.9915 (2.5); 6.9464 (2.9); 6.8477 (1.6); 6.8324 (1.3); 6.3986 (1.0); 4.1142 (0.9); 4.0484 (16.0); 3.7468 (1.1); 3.7335 (2.9); 3.7207 (3.0); 3.7073 (1.1); 2.9127 (2.0); 2.8988 (3.9); 2.8851 (1.9); 2.3115 (0.9); 2.2892 (0.9); 2.2844 (0.8); 2.2715 (12.9); 2.2470 (12.0); 2.1884 (0.4); 1.5738 (1.9); 1.2559 (0.9); -0.0002 (2.5)
I-120:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5382 (3.3); 7.5340 (2.3); 7.5245 (4.9); 7.5211 (5.8); 7.4283 (3.5); 7.4154 (1.5); 7.4065 (1.1); 7.4009 (1.9); 7.3943 (1.3); 7.3851 (1.0); 7.3769 (0.7); 7.3240 (4.0); 7.2985 (12.6); 7.1766 (4.8); 7.1503 (3.4); 6.4488 (1.3); 6.4220 (1.4); 5.4046 (1.1); 5.3802 (1.4); 5.3555 (1.1); 2.3627 (16.0); 2.3218 (0.4); 1.9456 (0.4); 1.9259 (1.0); 1.9167 (1.0); 1.9065 (0.7); 1.8970 (1.9); 1.8886 (0.6); 1.8775 (1.1); 1.8682 (1.1); 1.8486 (0.6); 1.6565 (9.7); 1.6334 (10.5); 1.6237 (4.3); 1.5908 (0.5); 1.1428 (0.7); 1.1366 (0.7); 1.1200 (0.8); 1.1140 (1.1); 1.1072 (1.5); 1.1018 (1.0); 1.0909 (0.8); 1.0868 (0.7); 1.0779 (1.0); 1.0724 (0.9); 1.0654 (1.0); 1.0559 (1.0); 1.0520 (0.9); 1.0409 (1.0); 1.0371 (1.0); 1.0271 (1.2); 1.0235 (1.5); 1.0123 (0.8); 0.9960 (0.6); 0.9875 (0.5); 0.9824 (0.7); 0.9732 (0.5); 0.9602 (0.8); 0.9527 (1.6); 0.9421 (3.7); 0.9330 (2.4); 0.9226 (3.6); 0.9162 (1.6); 0.9124 (1.2); 0.9079 (1.0); 0.0375 (6.6)
I-121:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3205 (1.3); 9.3049 (2.7); 9.2892 (1.3); 8.3005 (1.8); 8.2811 (3.7); 8.2612 (2.2); 8.0755 (14.7); 7.9528 (2.4); 7.8805 (5.0); 7.8618 (4.6); 7.8157 (0.7); 7.8071 (0.6); 7.7866 (0.5); 7.7368 (4.6); 7.7321 (4.8); 7.6975 (0.6); 7.6790 (0.5); 7.6658 (0.9); 7.6557 (0.4); 7.5822 (4.4); 7.5704 (4.6); 7.5615 (4.4); 7.5490 (5.3); 7.5354 (0.4); 7.5140 (1.0); 7.5001 (0.6); 7.4956 (0.5); 7.3016 (2.7); 7.2966 (2.8); 7.2805 (2.4); 7.2754 (2.4); 5.0320 (0.4); 4.2118 (1.3); 4.1958 (1.4); 4.1770 (3.0); 4.1612 (2.9); 4.1419 (1.5); 4.1263 (1.4); 3.3014 (32.4); 2.8907 (16.0); 2.7315 (14.0); 2.5094 (7.5); 2.5053 (15.4); 2.5008 (21.1); 2.4964 (15.4); 0.0079 (0.4); -0.0002 (9.7); -0.0083 (0.4)
I-122:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1030 (1.8); 9.0875 (3.8); 9.0719 (1.8); 7.9609 (2.6); 7.8644 (7.1); 7.6340 (2.1); 7.6142 (5.0); 7.5945 (3.3); 7.5549 (15.0); 7.4960 (8.0); 7.4750 (11.5); 7.4441 (5.1); 7.4402 (5.0); 7.4231 (2.4); 7.4190 (2.5); 7.3829 (6.0); 7.3434 (3.4); 7.3232 (2.9); 7.2296 (2.8); 7.0903 (6.1); 6.9511 (3.0); 4.2765 (1.7); 4.2609 (1.9); 4.2420 (3.8); 4.2265 (3.7); 4.2076 (2.0); 4.1919 (1.8); 3.3117 (31.6); 2.8985 (16.0); 2.7397 (14.5); 2.5129 (14.0); 2.5087 (18.6); 2.5045 (14.0); 2.3118 (0.7); 2.2996 (1.6); 2.2909 (1.8); 2.2789 (3.2); 2.2669 (2.0); 2.2585 (1.7); 2.2463 (0.9); 1.0960 (1.4); 1.0846 (4.0); 1.0781 (5.8); 1.0693 (3.7); 1.0640 (4.1); 1.0577 (5.2); 1.0493 (2.4); 1.0332 (0.8); 1.0202 (0.6); 1.0134 (0.6); 0.9965 (2.4); 0.9879 (5.8); 0.9824 (5.7); 0.9763 (6.3); 0.9701 (5.2); 0.9584 (1.6)
I-123:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0619 (1.9); 7.9539 (0.8); 7.8006 (4.9); 7.7519 (2.8); 7.7475 (1.5); 7.7306 (4.6); 7.7071 (1.0); 7.6621 (3.1); 7.6458 (4.6); 7.6288 (1.0); 7.6244 (2.7); 7.5991 (1.0); 7.5810 (0.7); 3.3721 (23.4); 3.3642 (38.9); 2.8927 (5.7); 2.7340 (4.8); 2.6448 (0.6); 2.6194 (12.1); 2.5149 (5.8); 2.5105 (12.3); 2.5060 (16.6); 2.5014 (11.9); 2.4970 (5.8); 1.6319 (16.0); 1.2996 (0.4)
I-124:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5861 (3.7); 7.5823 (3.8); 7.5786 (2.9); 7.5712 (2.4); 7.5455 (3.5); 7.5196 (2.1); 7.5000 (0.6); 7.4949 (0.6); 7.4016 (8.2); 7.3980 (7.9); 7.3626 (1.4); 7.3352 (1.9); 7.3060 (3.7); 7.2985 (11.5); 7.2934 (4.4); 7.2012 (0.4); 7.1953 (0.5); 7.1854 (0.5); 6.4393 (1.3); 6.0962 (0.8); 6.0857 (0.9); 6.0803 (0.6); 6.0737 (0.9); 6.0631 (0.7); 5.9413 (0.8); 5.9306 (0.8); 5.9247 (0.6); 5.9187 (0.9); 5.9079 (0.7); 4.2770 (0.4); 4.2660 (0.4); 4.2557 (0.4); 4.2447 (0.4); 4.2283 (0.5); 4.2176 (0.5); 4.2067 (0.6); 4.1957 (0.7); 4.1913 (0.8); 4.1791 (0.6); 4.1683 (1.3); 4.1629 (0.7); 4.1443 (1.3); 4.1308 (0.6); 4.1204 (0.8); 4.0035 (0.4); 3.9838 (0.6); 3.9612 (0.5); 3.9548 (0.5); 3.9292 (0.7); 3.9090 (0.8); 3.8862 (0.6); 3.8800 (0.6); 3.8606 (0.7); 3.8422 (0.5); 3.1032 (0.5); 2.6412 (15.4); 2.6363 (7.6); 2.6255 (2.5); 2.3421 (16.0); 2.3374 (7.4); 2.0801 (4.4); 2.0750 (1.8); 1.8674 (0.7); 1.3192 (1.2); 1.3140 (0.6); 1.2954 (2.6); 1.2904 (1.2); 1.2716 (1.2); 1.2666 (0.5); 0.0372 (12.3); 0.0321 (4.7)
I-125:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3180 (14.0); 7.8980 (1.3); 7.5322 (1.6); 7.5226 (2.3); 7.5135 (1.7); 7.5038 (2.3); 7.4957 (1.1); 7.4823 (1.2); 7.4655 (1.6); 7.4531 (2.0); 7.4421 (1.2); 7.4065 (2.4); 7.3775 (6.3); 7.3516 (4.4); 7.3016 (22.6); 7.0918 (3.9); 7.0171 (2.2); 6.9906 (1.8); 5.3412 (1.8); 4.3071 (2.1); 4.2873 (2.0); 4.2586 (4.4); 4.2389 (4.2); 4.2101 (2.2); 4.1903 (2.1); 2.5221 (6.5); 2.5151 (11.8); 2.5077 (6.5); 2.3704 (0.5); 2.3394 (16.0); 1.5946 (9.9); 0.0512 (0.6); 0.0404 (18.1); 0.0295 (0.6)
I-126:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9872 (1.1); 7.5531 (0.5); 7.5336 (2.2); 7.5177 (5.7); 7.4086 (2.9); 7.3646 (1.1); 7.3582 (1.9); 7.3528 (1.4); 7.3420 (1.3); 7.2596 (14.4); 7.0336 (2.4); 7.0145 (2.9); 6.9679 (3.2); 6.8670 (1.8); 6.8483 (1.4); 6.0100 (0.7); 5.9964 (1.3); 5.9819 (0.7); 3.7789 (1.4); 3.7618 (3.6); 3.7466 (3.6); 3.7296 (1.4); 2.9550 (2.9); 2.9480 (8.3); 2.9382 (4.9); 2.9209 (2.2); 2.8691 (6.9); 2.2999 (16.0); 2.2807 (1.3); 2.2542 (14.8); 2.1940 (0.5); 2.1584 (0.6); 1.9213 (0.4); 1.9068 (0.9); 1.8998 (0.9); 1.8922 (0.6); 1.8851 (1.8); 1.8782 (0.7); 1.8704 (1.0); 1.8634 (1.0); 1.8488 (0.5); 1.5549 (21.2); 1.1427 (0.8); 1.1262 (2.8); 1.1132 (1.5); 1.1078 (2.6); 1.1047 (2.5); 1.0919 (1.0); 0.9504 (1.1); 0.9353 (3.4); 0.9210 (3.1); 0.9071 (0.7); -0.0002 (4.2)
I-127:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 13.2756 (0.4); 9.2965 (1.2); 9.2840 (2.5); 9.2715 (1.2); 8.2917 (1.7); 8.2759 (3.2); 8.2600 (1.9); 8.1212 (9.9); 8.1025 (0.4); 8.0865 (0.7); 8.0706 (0.4); 7.9536 (2.6); 7.8855 (1.0); 7.8734 (4.2); 7.8587 (4.1); 7.6947 (0.8); 7.6796 (0.8); 7.6482 (1.0); 7.6301 (0.4); 7.5995 (0.4); 7.5807 (3.7); 7.5640 (3.6); 7.5543 (5.2); 7.5373 (6.8); 7.5166 (7.2); 7.4394 (6.4); 7.4224 (4.9); 4.9358 (0.3); 4.9081 (0.7); 4.8801 (0.4); 4.0594 (1.2); 4.0468 (1.2); 4.0313 (2.6); 4.0188 (2.5); 4.0032 (1.3); 3.9907 (1.2); 3.3247 (25.0); 2.8909 (16.0); 2.7316 (14.3); 2.5055 (14.6); 2.5023 (18.7); 2.4990 (13.7); -0.0002 (5.8)
I-128:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9035 (1.9); 8.8135 (1.8); 8.8051 (1.8); 8.1862 (5.2); 7.9331 (1.3); 7.9267 (1.9); 7.9202 (1.2); 7.8980 (0.5); 7.8803 (0.7); 7.8609 (0.4); 7.4736 (1.8); 7.4453 (4.5); 7.4400 (2.0); 7.3141 (1.7); 7.3071 (1.7); 7.2994 (6.7); 7.2862 (1.2); 7.2795 (1.1); 6.1404 (0.5); 6.1301 (0.5); 6.1153 (0.5); 6.1050 (0.5); 5.9844 (0.5); 5.9739 (0.5); 5.9592 (0.5); 5.9489 (0.5); 5.3367 (0.5); 4.3320 (0.4); 4.3215 (0.4); 4.3091 (0.3); 4.2985 (0.4); 4.2370 (0.4); 4.2265 (0.4); 4.2140 (0.4); 4.2035 (0.3); 3.8773 (0.4); 3.8607 (0.4); 3.8520 (0.4); 3.8354 (0.4); 3.8286 (0.4); 3.8110 (0.6); 3.8033 (0.4); 3.7938 (0.4); 3.7861 (0.6); 3.7686 (0.4); 3.7617 (0.3); 2.7864 (16.0); 2.7755 (0.8); 2.7415 (0.5); 2.0813 (0.6); 1.6346 (2.4); 1.2948 (0.4); 1.2897 (0.4); 0.0349 (5.7)
I-129:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0912 (1.1); 9.0711 (1.1); 7.9526 (0.5); 7.7893 (4.8); 7.7245 (0.5); 7.7043 (1.5); 7.6839 (1.3); 7.6470 (1.8); 7.6345 (2.4); 7.6314 (2.6); 7.5706 (1.2); 7.5497 (0.9); 7.2544 (1.1); 7.2495 (1.3); 7.2226 (1.1); 7.2176 (1.3); 7.1619 (0.8); 7.1401 (1.3); 7.1365 (1.3); 7.0812 (1.4); 7.0594 (2.1); 7.0378 (0.9); 5.1043 (0.7); 5.0859 (1.1); 5.0676 (0.7); 3.7899 (16.0); 3.4045 (20.1); 3.3939 (20.2); 3.3792 (59.0); 2.8919 (3.3); 2.7334 (2.9); 2.6069 (13.8); 2.5154 (5.6); 2.5110 (11.8); 2.5065 (16.0); 2.5020 (11.6); 2.4975 (5.6); 1.4194 (5.3); 1.4020 (5.3)
I-130:1 H-NMR(300.2 MHz, CDCl3): δ= 7.7715 (4.4); 7.6348 (5.9); 7.6004 (2.8); 7.5950 (2.7); 7.5904 (2.7); 7.5829 (6.1); 7.5800 (5.8); 7.4578 (3.8); 7.4434 (1.6); 7.4313 (1.8); 7.4243 (1.4); 7.4133 (1.3); 7.4053 (0.8); 7.3365 (2.8); 7.3098 (3.6); 7.2983 (13.5); 7.0445 (3.4); 6.9311 (1.9); 6.9043 (1.6); 6.8034 (0.9); 6.7840 (1.6); 6.7643 (0.9); 4.1545 (1.4); 4.1339 (1.4); 4.1060 (3.0); 4.0854 (2.9); 4.0574 (1.5); 4.0370 (1.4); 2.4706 (9.7); 2.3412 (0.4); 2.2863 (12.9); 2.2133 (16.0); 2.0431 (0.3); 1.6032 (5.4); 0.1086 (0.5); 0.0387 (16.1)
I-131:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5676 (1.5); 7.5480 (6.4); 7.5325 (16.0); 7.5184 (1.8); 7.4845 (9.9); 7.4632 (14.5); 7.4260 (8.2); 7.3827 (14.7); 7.3610 (12.3); 7.3500 (3.9); 7.2596 (51.8); 6.6843 (4.6); 6.6549 (5.1); 6.6400 (5.4); 6.6105 (5.6); 6.2940 (2.1); 6.2790 (3.7); 6.2647 (2.0); 6.0283 (10.3); 5.9840 (9.0); 5.7952 (10.2); 5.7657 (9.5); 4.1719 (3.7); 4.1562 (3.7); 4.1360 (7.7); 4.1202 (7.3); 4.0999 (3.9); 4.0842 (3.7); 1.5402 (40.9); 1.3050 (0.7); 1.2654 (3.1); 0.8987 (1.5); 0.8821 (3.7); 0.8645 (1.6); -0.0002 (49.7)
I-132:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2424 (16.0); 8.0141 (1.9); 7.5978 (1.7); 7.5782 (5.1); 7.5664 (3.8); 7.5469 (4.3); 7.5273 (1.5); 7.2597 (29.6); 7.1837 (6.3); 7.1036 (8.2); 7.0835 (4.2); 7.0699 (3.0); 7.0504 (2.8); 6.9828 (3.4); 6.9632 (6.5); 6.9438 (3.4); 6.8488 (3.4); 6.8291 (2.5); 3.4883 (0.8); 3.4767 (1.4); 3.4688 (1.6); 3.4576 (2.7); 3.4462 (1.7); 3.4385 (1.6); 3.4270 (0.9); 2.9530 (14.7); 2.8805 (13.3); 2.5035 (1.1); 2.4834 (2.6); 2.4639 (2.6); 2.4439 (1.2); 1.5522 (14.9); 1.5296 (3.1); 1.5249 (2.2); 1.5123 (2.2); 1.5075 (2.9); 1.4900 (1.7); 1.1968 (1.7); 1.1859 (1.9); 1.1799 (3.1); 1.1692 (3.1); 1.1633 (1.8); 1.1524 (1.5); 0.0080 (0.4); -0.0002 (12.4)
I-133:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6229 (2.6); 7.6055 (3.6); 7.4812 (1.8); 7.4480 (0.8); 7.4393 (0.8); 7.4331 (1.1); 7.4265 (0.9); 7.4178 (0.7); 7.4096 (0.5); 7.3724 (1.7); 7.3458 (2.0); 7.2988 (2.5); 7.0966 (2.0); 7.0065 (1.1); 6.9803 (1.0); 6.6986 (0.5); 6.6781 (1.0); 6.6578 (0.5); 4.2905 (0.9); 4.2696 (0.8); 4.2421 (1.8); 4.2211 (1.7); 4.1936 (0.9); 4.1726 (0.9); 2.5240 (6.4); 2.5109 (16.0); 2.3332 (7.7); 1.6479 (2.6); 1.3044 (0.3); 1.2936 (0.4); 0.0378 (1.8)
I-134:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5512 (0.8); 7.5291 (1.5); 7.5140 (1.8); 7.4909 (1.0); 7.3943 (2.0); 7.3678 (2.4); 7.3373 (1.1); 7.3097 (1.6); 7.2986 (4.3); 7.2833 (0.7); 7.0769 (2.6); 6.9867 (1.3); 6.9603 (1.2); 6.4945 (0.6); 6.4739 (1.0); 6.4535 (0.6); 4.2947 (1.1); 4.2737 (1.0); 4.2463 (2.3); 4.2253 (2.2); 4.1979 (1.2); 4.1867 (0.3); 4.1769 (1.1); 4.1631 (0.4); 4.1393 (0.4); 2.6180 (16.0); 2.5314 (7.2); 2.4366 (0.4); 2.4294 (0.3); 2.3531 (0.9); 2.3139 (9.8); 2.2875 (16.0); 2.2034 (0.3); 2.0759 (1.7); 1.3168 (0.4); 1.2931 (1.0); 1.2692 (0.4); 0.0377 (3.7)
I-135:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3301 (9.1); 8.0361 (1.4); 7.4849 (1.6); 7.4581 (4.2); 7.4312 (3.4); 7.3810 (6.0); 7.3545 (5.3); 7.3308 (0.5); 7.2985 (16.4); 7.2762 (2.9); 7.2693 (4.7); 7.2627 (2.9); 7.1867 (2.4); 7.1827 (2.2); 7.1632 (1.9); 7.1599 (2.0); 7.1559 (1.9); 7.1146 (0.4); 7.0799 (4.2); 7.0019 (2.2); 6.9750 (1.9); 5.1589 (3.3); 5.1385 (4.9); 5.1308 (4.2); 5.1104 (5.2); 5.0412 (4.8); 5.0197 (7.5); 4.9986 (3.8); 4.7039 (0.7); 4.6813 (1.4); 4.6763 (1.3); 4.6534 (2.1); 4.6308 (1.1); 4.6257 (1.0); 4.6030 (0.4); 4.3135 (1.7); 4.2938 (1.7); 4.2655 (3.6); 4.2457 (3.5); 4.2174 (1.9); 4.1975 (1.9); 3.4198 (0.4); 3.3835 (0.6); 3.2934 (0.5); 2.5181 (11.4); 2.4414 (0.4); 2.3346 (16.0); 2.0428 (4.7); 1.6386 (0.7); 1.4971 (0.3); 1.4510 (0.6); 1.2937 (6.8); 1.1453 (1.3); 0.9587 (0.4); 0.9179 (1.0); 0.8937 (1.1); 0.8708 (0.7); 0.2087 (0.8); 0.1891 (1.3); 0.1084 (0.4); 0.0483 (0.6); 0.0376 (14.9)
I-136:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5149 (1.0); 7.5010 (2.5); 7.4218 (1.3); 7.3785 (0.6); 7.3741 (0.9); 7.3698 (0.6); 7.3605 (0.7); 7.3561 (0.5); 7.3489 (1.2); 7.3329 (1.2); 7.2593 (2.2); 7.0358 (1.4); 6.9730 (0.8); 6.9572 (0.7); 6.8458 (0.4); 6.8338 (0.7); 6.8218 (0.4); 4.2642 (5.2); 4.1917 (0.5); 4.1792 (0.5); 4.1614 (1.1); 4.1490 (1.0); 4.1313 (0.6); 4.1188 (0.5); 3.2589 (9.2); 2.4699 (4.0); 2.2687 (5.4); 1.3010 (16.0); 1.2654 (0.7); 0.8819 (0.6); -0.0002 (2.8)
I-137:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0105 (3.9); 8.0019 (3.9); 7.6562 (0.5); 7.6296 (3.3); 7.6231 (3.1); 7.6183 (3.3); 7.6116 (7.4); 7.6084 (7.7); 7.5237 (3.7); 7.5023 (0.6); 7.4872 (1.7); 7.4759 (2.2); 7.4692 (2.0); 7.4573 (1.5); 7.4496 (1.0); 7.3374 (3.5); 7.3105 (4.4); 7.2984 (18.7); 7.0590 (4.1); 6.9789 (2.3); 6.9462 (3.4); 6.8332 (4.0); 6.8245 (3.8); 6.7633 (4.5); 6.6170 (1.1); 6.5976 (1.9); 6.5809 (3.1); 4.1196 (1.9); 4.0989 (1.8); 4.0697 (3.9); 4.0491 (3.7); 4.0198 (2.0); 3.9993 (1.9); 2.4574 (11.9); 2.3511 (0.5); 2.3063 (16.0); 2.0429 (0.5); 1.5965 (7.4); 0.1089 (0.8); 0.0494 (1.4); 0.0389 (22.5); 0.0280 (1.2)
I-138:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1750 (1.7); 9.1554 (1.7); 8.1047 (7.8); 7.3679 (1.3); 7.3485 (2.8); 7.3292 (1.7); 7.2073 (3.4); 7.1831 (4.6); 7.1711 (5.0); 7.1135 (2.1); 7.0944 (1.8); 7.0707 (4.3); 7.0483 (1.8); 7.0260 (1.8); 7.0165 (1.0); 5.0919 (1.1); 5.0736 (1.6); 5.0555 (1.1); 3.9021 (0.8); 3.3264 (71.8); 2.6707 (0.8); 2.5407 (0.9); 2.5057 (109.0); 2.5018 (131.7); 2.3387 (15.5); 2.1847 (16.0); 1.4319 (7.6); 1.4145 (7.5); -0.0002 (0.4)
I-139:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5648 (1.4); 7.5448 (6.8); 7.5291 (16.0); 7.4676 (10.8); 7.4630 (10.6); 7.4282 (8.3); 7.3650 (0.8); 7.3535 (3.0); 7.3468 (4.6); 7.3411 (3.9); 7.3312 (3.6); 7.2616 (8.9); 7.1971 (4.3); 7.1926 (4.1); 7.1767 (6.6); 7.1722 (6.4); 7.1076 (10.5); 7.0871 (6.6); 6.6454 (2.8); 6.6159 (3.1); 6.6012 (3.2); 6.5717 (3.3); 6.3179 (2.6); 6.0577 (0.4); 6.0301 (9.0); 5.9858 (7.6); 5.8198 (0.4); 5.7901 (0.6); 5.7769 (8.2); 5.7474 (7.5); 3.7356 (3.4); 3.7190 (9.3); 3.7028 (9.3); 3.6864 (3.4); 3.0067 (6.8); 2.9896 (13.1); 2.9725 (6.0); 2.0260 (0.8); 1.5927 (5.6); 1.2679 (0.6); 1.2560 (0.7); 1.2507 (0.7); 0.8811 (0.3); -0.0002 (8.0); -0.0082 (0.4)
I-140:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5652 (0.5); 7.5452 (5.4); 7.5323 (7.1); 7.4424 (3.9); 7.4085 (0.6); 7.3988 (1.6); 7.3923 (1.7); 7.3879 (2.2); 7.3831 (2.0); 7.3764 (1.5); 7.3703 (1.1); 7.3481 (3.4); 7.3281 (3.7); 7.2583 (6.3); 7.0441 (4.3); 6.9548 (2.3); 6.9352 (2.1); 6.4342 (1.0); 6.4194 (1.8); 6.4047 (1.0); 4.2375 (1.7); 4.2220 (1.8); 4.2014 (3.6); 4.1859 (3.4); 4.1652 (1.8); 4.1498 (1.7); 2.4783 (12.0); 2.3178 (0.5); 2.2737 (16.0); 1.5702 (1.0); 1.2559 (0.4); -0.0002 (5.1)
I-141:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2171 (0.7); 9.2028 (1.5); 9.1881 (0.8); 8.2950 (1.1); 8.2753 (2.0); 8.2555 (1.2); 8.1371 (7.3); 8.1245 (0.4); 7.9531 (2.5); 7.8640 (2.8); 7.8454 (2.6); 7.7457 (3.4); 7.6998 (0.4); 7.6148 (2.6); 7.5941 (2.5); 7.5248 (1.0); 7.5206 (1.0); 7.5040 (2.2); 7.4996 (2.3); 7.4716 (3.8); 7.4507 (1.8); 5.9230 (0.5); 5.9108 (1.0); 5.8978 (0.5); 5.8073 (0.5); 5.7956 (0.8); 5.7821 (0.5); 3.7820 (0.7); 3.7698 (1.5); 3.7555 (0.9); 3.7273 (0.6); 3.7197 (0.7); 3.7119 (1.2); 3.6964 (0.7); 3.3014 (10.9); 2.8909 (16.0); 2.7319 (14.3); 2.5053 (8.2); 2.5010 (11.1); 2.4967 (8.3); -0.0002 (4.3)
I-142:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0909 (1.4); 9.0761 (3.0); 9.0616 (1.5); 8.0813 (13.8); 7.7637 (1.1); 7.7443 (9.8); 7.7250 (3.4); 7.7072 (4.3); 7.6869 (6.6); 7.6041 (2.9); 7.5839 (2.3); 7.4958 (0.6); 7.4755 (16.0); 7.4510 (0.5); 6.0461 (1.1); 6.0330 (1.9); 6.0210 (1.1); 5.9307 (1.0); 5.9178 (2.0); 5.9056 (1.1); 3.8979 (1.7); 3.8828 (2.6); 3.8729 (1.3); 3.8675 (1.2); 3.8398 (1.9); 3.8257 (2.9); 3.8127 (1.4); 3.3214 (30.9); 2.6710 (0.9); 2.6667 (0.7); 2.5062 (117.2); 2.5019 (150.2); 2.4976 (108.9); 2.3328 (0.7); 2.3285 (0.9); 2.3241 (0.6); -0.0001 (0.8)
I-143:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9469 (1.2); 8.9256 (1.2); 7.8026 (5.0); 7.7189 (0.5); 7.6986 (1.4); 7.6782 (1.2); 7.6374 (1.6); 7.6237 (2.5); 7.6210 (2.6); 7.5793 (1.1); 7.5577 (0.9); 7.2172 (1.6); 7.1969 (1.6); 6.6562 (4.3); 6.6357 (1.3); 6.6290 (0.8); 5.1301 (0.6); 5.1125 (0.7); 3.6895 (16.0); 3.3643 (42.4); 2.8910 (1.3); 2.7320 (1.6); 2.7187 (1.3); 2.7042 (1.3); 2.6901 (0.5); 2.6030 (13.1); 2.5128 (5.8); 2.5085 (12.3); 2.5040 (16.7); 2.4995 (12.2); 2.4950 (6.0); 1.9702 (0.4); 1.9585 (0.5); 1.9493 (0.6); 1.9352 (0.3); 1.8823 (0.3); 1.8689 (0.4); 1.8563 (0.4); 1.8364 (0.4); 1.7657 (0.5); 1.7467 (0.9); 1.7368 (1.0); 1.7228 (0.8)
I-144:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6228 (0.6); 7.5964 (2.5); 7.5752 (7.5); 7.5534 (0.7); 7.5042 (3.4); 7.4751 (3.6); 7.4468 (9.3); 7.4404 (5.8); 7.4330 (1.9); 7.4184 (1.5); 7.4106 (0.9); 7.2988 (18.5); 7.2767 (3.0); 7.2698 (2.8); 7.2488 (2.2); 7.2420 (2.1); 6.4540 (0.9); 6.4336 (1.6); 6.4130 (0.9); 6.0965 (0.9); 6.0865 (1.0); 6.0723 (1.0); 6.0623 (0.9); 5.9407 (0.9); 5.9307 (1.0); 5.9166 (1.0); 5.9064 (0.9); 4.3068 (0.5); 4.2967 (0.5); 4.2843 (0.5); 4.2742 (0.5); 4.2579 (0.7); 4.2477 (0.7); 4.2355 (0.6); 4.2250 (0.6); 4.2145 (0.6); 4.2042 (0.5); 4.1919 (0.5); 4.1817 (0.5); 4.1654 (0.7); 4.1552 (0.6); 4.1429 (0.7); 4.1328 (0.6); 3.9394 (0.6); 3.9205 (0.7); 3.9150 (0.7); 3.8961 (0.7); 3.8903 (0.6); 3.8681 (1.1); 3.8483 (1.0); 3.8252 (0.7); 3.8197 (0.6); 3.8006 (0.6); 3.7953 (0.5); 3.7763 (0.5); 2.8578 (0.5); 2.8399 (0.8); 2.8326 (0.7); 2.8148 (2.6); 2.7952 (2.9); 2.7897 (2.8); 2.7704 (2.8); 2.7522 (0.8); 2.7457 (0.9); 2.7275 (0.5); 2.0431 (1.9); 1.6050 (16.0); 1.3515 (5.7); 1.3265 (13.0); 1.3014 (5.6); 0.0472 (0.6); 0.0363 (19.1); 0.0252 (0.7)
I-145:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5710 (0.6); 7.5465 (1.6); 7.5214 (1.6); 7.4942 (0.8); 7.3644 (1.0); 7.3491 (2.9); 7.3419 (3.6); 7.3090 (0.7); 7.3060 (0.7); 7.2985 (10.2); 7.2509 (2.2); 7.2235 (2.9); 7.0738 (1.8); 7.0667 (1.7); 7.0465 (1.3); 7.0394 (1.3); 6.1659 (0.4); 6.1479 (0.8); 6.1293 (0.4); 3.8857 (1.1); 3.8639 (2.9); 3.8426 (3.0); 3.8207 (1.2); 3.1384 (2.1); 3.1160 (3.9); 3.0937 (1.8); 2.6362 (0.7); 2.6219 (16.0); 2.3467 (16.0); 2.2077 (0.4); 2.0793 (0.8); 1.7589 (0.4); 1.2951 (0.5); 0.0478 (0.4); 0.0371 (10.6); 0.0261 (0.4)
I-146:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4303 (1.6); 7.4034 (3.8); 7.3771 (5.8); 7.3517 (3.9); 7.3219 (3.1); 7.2986 (25.6); 7.2252 (2.9); 7.2187 (4.5); 7.2125 (2.8); 7.1798 (0.4); 7.1511 (0.4); 7.1338 (2.3); 7.0885 (4.5); 7.0107 (2.3); 6.9847 (2.0); 6.7764 (0.9); 6.7568 (1.6); 6.7366 (0.9); 4.9659 (1.6); 4.9404 (3.8); 4.9288 (2.2); 4.9214 (2.2); 4.8928 (0.4); 4.8136 (1.8); 4.7860 (4.6); 4.7711 (5.6); 4.7296 (1.5); 4.7076 (0.6); 4.5952 (0.4); 4.2494 (1.5); 4.2290 (1.4); 4.2005 (3.0); 4.1801 (2.8); 4.1518 (1.6); 4.1316 (1.4); 3.7932 (1.1); 3.7698 (3.0); 3.7464 (3.1); 3.7230 (1.2); 3.5267 (8.0); 3.3959 (0.4); 3.3833 (0.5); 2.9902 (0.7); 2.9097 (0.6); 2.5071 (11.5); 2.3447 (16.0); 1.6380 (0.9); 1.5721 (0.6); 1.5105 (0.5); 1.4800 (0.7); 1.4507 (0.9); 1.3030 (7.6); 1.2940 (10.9); 1.2801 (8.7); 1.2567 (4.5); 1.1956 (0.6); 1.1444 (1.8); 1.0466 (0.3); 1.0274 (0.4); 1.0158 (0.4); 0.9816 (0.4); 0.9184 (1.7); 0.8936 (1.6); 0.8693 (1.1); 0.2431 (0.5); 0.2321 (0.4); 0.2218 (0.9); 0.2095 (1.1); 0.1811 (2.1); 0.1711 (2.2); 0.1078 (0.7); 0.0485 (1.1); 0.0378 (22.3); 0.0272 (1.3)
I-147:1 H-NMR(499.9 MHz, CDCl3): δ= 8.3199 (6.9); 7.8605 (1.2); 7.8454 (1.3); 7.6182 (0.4); 7.6007 (3.3); 7.5909 (6.6); 7.4925 (3.5); 7.4462 (0.3); 7.4376 (1.2); 7.4307 (1.8); 7.4269 (1.8); 7.4201 (1.5); 7.2592 (5.5); 6.5924 (6.6); 5.3524 (1.3); 5.3393 (1.5); 5.3266 (0.6); 2.6171 (0.3); 2.5832 (2.8); 2.5716 (2.8); 2.5383 (0.4); 2.2936 (0.4); 2.2843 (0.5); 2.2711 (1.2); 2.2632 (1.1); 2.2540 (0.8); 2.2435 (0.8); 2.2358 (0.4); 1.9206 (0.3); 1.9038 (1.5); 1.8897 (2.0); 1.8774 (3.2); 1.8732 (3.1); 1.8510 (1.3); 1.8296 (0.4); 1.5524 (1.8); 1.4224 (0.5); 1.3360 (0.7); 1.2840 (1.6); 1.2561 (16.0); 1.1608 (0.5); 1.1416 (0.4); 1.1304 (0.4); 1.1068 (0.7); 0.8928 (1.2); 0.8894 (1.2); 0.8804 (1.6); 0.8673 (1.2); 0.8412 (1.5); 0.7158 (0.4); -0.0002 (5.1)
I-148:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1927 (2.9); 7.6091 (0.4); 7.5815 (1.4); 7.5554 (5.8); 7.5338 (16.0); 7.5169 (2.3); 7.4890 (9.7); 7.4601 (15.8); 7.4347 (3.6); 7.4142 (2.5); 7.3855 (7.6); 7.3632 (13.5); 7.3348 (11.4); 7.3267 (6.6); 7.3194 (3.7); 7.3122 (2.4); 7.2986 (47.4); 5.4637 (0.4); 4.2048 (4.0); 4.1845 (3.9); 4.1730 (0.8); 4.1578 (8.4); 4.1374 (8.1); 4.1107 (4.2); 4.0904 (4.1); 4.0504 (0.4); 4.0295 (0.4); 3.1671 (0.6); 3.1547 (1.4); 3.1443 (2.5); 3.1321 (3.4); 3.1219 (3.4); 3.1095 (2.6); 3.0991 (1.5); 3.0871 (0.7); 2.3765 (0.9); 2.3594 (2.2); 2.3490 (2.3); 2.3424 (1.6); 2.3322 (4.4); 2.3217 (1.6); 2.3150 (2.5); 2.3048 (2.3); 2.2878 (1.1); 1.6086 (12.7); 1.4613 (0.3); 1.3710 (0.4); 1.3217 (0.8); 1.2934 (4.2); 1.2557 (0.6); 1.2200 (2.6); 1.2050 (7.6); 1.1974 (8.6); 1.1883 (8.0); 1.1805 (8.3); 1.1679 (3.5); 1.1346 (0.6); 1.1182 (0.6); 1.0839 (0.7); 1.0633 (0.5); 1.0556 (0.6); 1.0338 (3.6); 1.0212 (7.9); 1.0131 (6.9); 1.0066 (4.6); 0.9941 (7.9); 0.9859 (7.1); 0.9713 (2.6); 0.9250 (2.3); 0.9191 (1.8); 0.9079 (5.8); 0.9016 (8.1); 0.8848 (8.4); 0.8787 (6.8); 0.8617 (3.3); 0.8320 (0.6); 0.8093 (0.6); 0.7966 (0.6); 0.7832 (0.5); 0.7432 (2.9); 0.7274 (7.0); 0.7195 (8.3); 0.7148 (7.0); 0.7077 (5.9); 0.6908 (2.1); 0.1073 (5.4); 0.0480 (1.1); 0.0372 (34.6); 0.0262 (1.3)
I-149:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6475 (2.2); 7.6423 (1.7); 7.6302 (3.8); 7.5815 (2.0); 7.5531 (2.4); 7.5380 (1.9); 7.5342 (1.9); 7.5320 (2.0); 7.4885 (1.9); 7.4576 (0.4); 7.4440 (0.9); 7.4356 (0.9); 7.4294 (1.3); 7.4233 (1.0); 7.4136 (0.7); 7.4054 (0.6); 7.2986 (7.8); 7.2633 (1.3); 7.2567 (1.2); 7.2351 (1.0); 7.2284 (1.0); 6.6051 (0.5); 6.5840 (0.9); 6.5628 (0.5); 4.4884 (0.9); 4.4670 (0.9); 4.4518 (0.3); 4.4398 (2.0); 4.4184 (1.9); 4.3912 (1.0); 4.3698 (0.9); 2.5840 (16.0); 2.5607 (1.8); 1.6228 (4.4); 1.2914 (1.3); 0.9176 (0.6); 0.0357 (5.3)
I-150:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1912 (1.3); 9.1714 (1.4); 7.8021 (6.2); 7.7319 (0.6); 7.7121 (1.8); 7.6925 (1.5); 7.6689 (2.3); 7.6547 (2.0); 7.6353 (1.0); 7.6096 (2.8); 7.5915 (1.4); 7.5718 (1.0); 7.4228 (1.4); 7.4177 (1.9); 7.4142 (1.6); 7.4034 (1.9); 7.3982 (2.8); 7.3943 (2.0); 7.2754 (2.1); 7.2559 (3.1); 7.2364 (1.3); 5.1556 (0.8); 5.1372 (1.2); 5.1191 (0.8); 3.3526 (18.2); 2.8912 (1.2); 2.7332 (1.0); 2.6096 (16.0); 2.5139 (4.5); 2.5095 (9.6); 2.5050 (13.0); 2.5004 (9.4); 2.4960 (4.6); 1.4425 (6.2); 1.4250 (6.1)
I-151:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1772 (4.8); 8.0487 (0.4); 8.0302 (0.6); 7.6460 (1.4); 7.6393 (1.2); 7.6347 (1.2); 7.6278 (3.4); 7.6245 (3.2); 7.5124 (1.6); 7.4773 (0.7); 7.4656 (0.9); 7.4590 (0.8); 7.4469 (0.7); 7.4389 (0.4); 7.3754 (1.6); 7.3488 (1.8); 7.2987 (7.5); 7.0704 (1.7); 6.9811 (1.0); 6.9546 (0.8); 4.3137 (0.9); 4.2939 (0.9); 4.2655 (1.9); 4.2457 (1.8); 4.2174 (1.0); 4.1975 (1.0); 4.1703 (0.4); 4.1466 (0.4); 3.1040 (1.0); 3.0787 (3.3); 3.0534 (3.4); 3.0280 (1.2); 2.5225 (3.0); 2.5158 (5.3); 2.5085 (3.0); 2.3133 (7.2); 2.0832 (1.6); 1.6161 (16.0); 1.4315 (3.8); 1.4062 (8.0); 1.3809 (3.7); 1.3203 (0.8); 1.2965 (2.4); 1.2727 (0.6); 0.9402 (0.5); 0.9184 (1.6); 0.8953 (0.6); 0.1071 (1.8); 0.0364 (6.4)
I-152:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0046 (0.4); 8.9895 (1.0); 8.9741 (1.0); 8.9591 (0.4); 7.7689 (4.8); 7.7285 (0.6); 7.7088 (1.6); 7.6887 (1.4); 7.6626 (1.9); 7.6392 (1.6); 7.6335 (1.5); 7.6172 (1.0); 7.5532 (1.8); 7.5498 (2.1); 7.5467 (2.0); 7.5356 (2.0); 7.5150 (1.7); 7.4745 (1.2); 7.4540 (2.1); 7.4242 (1.0); 7.4199 (0.9); 7.4039 (0.7); 7.3995 (0.6); 7.3020 (0.7); 7.2985 (0.7); 7.2820 (0.7); 6.3576 (1.0); 6.3487 (2.4); 6.0462 (0.4); 6.0150 (0.4); 5.9308 (0.5); 5.9189 (0.3); 5.8988 (0.5); 5.4665 (1.6); 5.1691 (1.4); 4.0377 (1.0); 4.0199 (1.0); 3.8871 (0.3); 3.8748 (0.5); 3.8661 (0.9); 3.8530 (0.9); 3.8389 (0.4); 3.8276 (0.6); 3.8114 (1.1); 3.7965 (1.0); 3.7826 (0.4); 3.3247 (38.8); 2.6755 (0.6); 2.6709 (0.9); 2.6664 (0.7); 2.5975 (16.0); 2.5244 (2.9); 2.5198 (4.4); 2.5110 (51.9); 2.5065 (105.2); 2.5019 (139.8); 2.4973 (102.5); 2.4929 (50.2); 2.3333 (0.6); 2.3288 (0.9); 2.3243 (0.6); 2.0491 (5.2); 1.9889 (4.2); 1.8421 (2.0); 1.8307 (2.1); 1.3976 (3.4); 1.1927 (1.2); 1.1749 (2.3); 1.1571 (1.1); -0.0002 (4.5)
I-153:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4031 (1.5); 7.3765 (1.7); 7.2986 (10.2); 7.1174 (0.3); 7.0906 (3.3); 7.0764 (3.4); 7.0730 (3.7); 7.0636 (1.6); 7.0453 (0.4); 7.0111 (1.0); 6.9843 (0.8); 6.8402 (0.6); 6.8233 (0.8); 6.8183 (0.7); 6.8087 (1.0); 6.7948 (0.5); 6.7861 (0.4); 6.5500 (0.4); 6.5303 (0.7); 6.5108 (0.4); 4.3415 (0.5); 4.3017 (0.8); 4.2806 (0.8); 4.2527 (1.8); 4.2316 (1.7); 4.2035 (0.9); 4.1825 (0.9); 4.0773 (16.0); 2.5239 (5.3); 2.5172 (3.0); 2.3785 (0.4); 2.3335 (6.9); 2.1266 (0.4); 2.1158 (0.5); 2.0985 (0.8); 2.0816 (0.6); 2.0702 (0.5); 1.5897 (6.2); 1.2967 (0.5); 1.0682 (0.6); 1.0528 (1.6); 1.0460 (1.7); 1.0314 (0.9); 1.0242 (1.7); 1.0177 (1.6); 1.0031 (0.8); 0.9207 (0.5); 0.8077 (0.8); 0.7927 (1.8); 0.7868 (1.8); 0.7757 (1.7); 0.7700 (2.0); 0.7537 (0.6); 0.1084 (0.3); 0.0494 (0.4); 0.0386 (12.6); 0.0277 (0.5)
I-154:1 H-NMR(400.1 MHz, CDCl3): δ= 7.6881 (0.4); 7.6355 (8.6); 7.5790 (1.6); 7.5595 (5.8); 7.5424 (16.0); 7.5284 (1.9); 7.5190 (1.7); 7.4557 (12.8); 7.4348 (10.6); 7.4177 (0.6); 7.4059 (0.7); 7.3911 (3.2); 7.3852 (5.4); 7.3798 (3.5); 7.3759 (2.5); 7.3677 (4.1); 7.3610 (7.4); 7.3565 (6.0); 7.3396 (3.9); 7.3353 (3.8); 7.2595 (57.9); 6.7008 (4.9); 6.6714 (5.5); 6.6565 (5.8); 6.6271 (5.9); 6.2856 (2.0); 6.2698 (3.6); 6.2547 (2.0); 6.0524 (10.4); 6.0081 (9.1); 5.8384 (0.4); 5.8223 (10.4); 5.8091 (0.5); 5.7929 (9.6); 4.3791 (3.5); 4.3631 (3.5); 4.3425 (7.4); 4.3265 (7.0); 4.3059 (3.7); 4.2900 (3.5); 3.3694 (0.8); 1.5387 (33.2); 1.3031 (0.5); 1.2648 (2.3); 0.8986 (1.1); 0.8820 (2.9); 0.8643 (1.3); 0.0078 (3.2); -0.0002 (59.6); -0.0084 (2.7)
I-155:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5401 (4.7); 7.5272 (5.2); 7.4270 (3.0); 7.4017 (0.4); 7.3923 (1.3); 7.3861 (1.3); 7.3800 (1.8); 7.3754 (1.5); 7.3698 (1.2); 7.3635 (0.9); 7.3433 (3.8); 7.3191 (2.6); 7.3043 (1.6); 7.2859 (2.6); 7.2670 (1.5); 7.2591 (5.5); 7.2466 (2.3); 7.2281 (1.1); 6.4631 (0.8); 6.4484 (1.4); 6.4335 (0.8); 4.2025 (1.4); 4.1870 (1.4); 4.1667 (3.0); 4.1512 (2.8); 4.1309 (1.5); 4.1154 (1.4); 2.3745 (0.4); 2.3467 (16.0); 1.5702 (1.6); 1.2988 (0.4); 1.2866 (0.4); 1.2822 (0.4); 1.2699 (0.4); 1.2563 (0.7); 0.0714 (0.6); -0.0002 (4.2)
I-156:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2499 (16.0); 8.0864 (0.7); 8.0161 (1.6); 7.8729 (0.5); 7.6047 (2.0); 7.5854 (4.7); 7.5650 (3.4); 7.5452 (4.4); 7.5255 (1.7); 7.3756 (2.0); 7.3207 (0.4); 7.2596 (29.7); 7.1954 (3.2); 7.1766 (4.0); 7.0988 (2.8); 7.0790 (2.7); 7.0534 (2.6); 7.0381 (7.4); 7.0187 (2.0); 7.0162 (2.0); 6.9339 (3.2); 6.9312 (3.3); 6.9140 (5.4); 6.9113 (4.9); 6.8577 (2.5); 6.8549 (2.4); 6.8370 (3.4); 6.8195 (1.3); 6.8168 (1.3); 3.5217 (0.8); 3.5115 (1.7); 3.5018 (2.0); 3.4925 (2.6); 3.4835 (2.1); 3.4739 (1.8); 3.4636 (0.9); 2.9535 (12.5); 2.8813 (11.4); 2.5162 (1.1); 2.4961 (2.8); 2.4763 (2.9); 2.4563 (1.2); 1.6254 (1.6); 1.6085 (3.0); 1.6034 (2.0); 1.5916 (2.2); 1.5865 (3.0); 1.5694 (2.4); 1.5532 (6.5); 1.4098 (1.4); 1.3941 (1.3); 1.2109 (1.6); 1.2004 (1.8); 1.1940 (2.8); 1.1837 (2.8); 1.1773 (1.7); 1.1668 (1.5); 0.0078 (0.5); -0.0002 (13.1); -0.0082 (0.6)
I-157:1 H-NMR(300.2 MHz, CDCl3): δ= 9.5213 (1.4); 8.7150 (6.7); 8.7097 (4.4); 8.7001 (4.4); 8.6949 (6.8); 8.0787 (0.9); 8.0598 (1.7); 8.0416 (0.9); 7.6316 (0.6); 7.6055 (3.5); 7.5996 (3.0); 7.5946 (3.1); 7.5877 (7.7); 7.5843 (7.7); 7.5742 (1.2); 7.5689 (1.3); 7.5482 (8.0); 7.5429 (5.0); 7.5334 (5.0); 7.5280 (7.7); 7.4641 (3.8); 7.4487 (0.9); 7.4417 (0.7); 7.4335 (1.7); 7.4218 (2.4); 7.4152 (2.1); 7.4035 (1.7); 7.3952 (1.0); 7.3589 (3.6); 7.3323 (4.1); 7.2986 (8.4); 7.0576 (4.0); 6.9542 (2.2); 6.9278 (1.9); 4.2552 (1.8); 4.2358 (1.8); 4.2074 (3.9); 4.1879 (3.7); 4.1594 (2.0); 4.1399 (1.9); 2.5037 (11.8); 2.4965 (6.9); 2.3628 (0.5); 2.3085 (16.0); 2.2280 (0.4); 2.2151 (0.8); 2.2062 (1.2); 2.1929 (1.6); 2.1844 (1.5); 2.1714 (1.2); 2.1627 (0.8); 2.1497 (0.3); 1.7133 (2.4); 1.2936 (1.2); 0.4755 (0.6); 0.4615 (1.0); 0.4486 (3.1); 0.4356 (5.0); 0.4223 (2.9); 0.4130 (2.6); 0.4055 (2.9); 0.3985 (3.2); 0.3913 (3.1); 0.3754 (2.9); 0.3499 (0.7); 0.1089 (2.8); 0.0474 (0.4); 0.0366 (8.3); 0.0256 (0.4)
I-158:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.1372 (0.4); 8.7318 (0.6); 8.7248 (0.6); 8.0804 (2.3); 7.9699 (0.4); 7.9619 (0.4); 7.9418 (0.5); 7.9337 (0.5); 7.7379 (0.8); 7.7097 (0.7); 7.6485 (0.5); 7.6224 (0.4); 7.5460 (0.4); 7.4446 (0.6); 7.4166 (0.3); 7.4131 (0.4); 7.2993 (0.3); 7.1137 (0.8); 6.9282 (0.4); 4.2577 (0.5); 4.2367 (0.4); 3.3457 (16.0); 2.5343 (0.6); 2.5283 (1.2); 2.5223 (1.7); 2.5162 (1.2); 2.5104 (0.6); 1.2558 (0.3); 0.0199 (0.8)
I-159:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2111 (1.6); 9.1909 (1.6); 7.9531 (1.3); 7.8137 (5.7); 7.7966 (2.9); 7.7525 (2.0); 7.7313 (2.9); 7.7137 (1.9); 7.6927 (2.4); 7.6862 (2.6); 7.6658 (2.1); 7.6466 (1.0); 7.5992 (3.5); 7.5771 (3.3); 7.5206 (1.6); 7.5170 (1.7); 7.4993 (1.3); 7.4956 (1.4); 7.2727 (2.4); 7.2669 (2.6); 7.1020 (1.6); 7.0958 (1.5); 7.0797 (1.4); 7.0734 (1.4); 5.2930 (0.8); 5.2749 (1.2); 5.2563 (0.8); 3.8489 (16.0); 3.3585 (45.7); 3.3538 (51.4); 2.8900 (7.6); 2.7320 (7.0); 2.6114 (14.5); 2.5083 (17.8); 2.5040 (23.9); 2.4997 (18.1); 1.5299 (5.6); 1.5125 (5.6); -0.0002 (0.4)
I-160:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1859 (5.9); 8.0649 (0.5); 8.0475 (0.8); 8.0302 (0.5); 7.6589 (1.6); 7.6386 (4.5); 7.6231 (0.4); 7.6189 (0.4); 7.5396 (2.1); 7.4815 (0.9); 7.4712 (1.4); 7.4640 (3.1); 7.4507 (1.0); 7.4358 (4.6); 7.4258 (1.9); 7.2985 (7.9); 7.2658 (1.7); 7.2590 (1.6); 7.2379 (1.3); 7.2313 (1.2); 6.1459 (0.5); 6.1354 (0.6); 6.1222 (0.6); 6.1117 (0.6); 5.9904 (0.5); 5.9800 (0.6); 5.9668 (0.6); 5.9562 (0.6); 4.3162 (0.4); 4.3054 (0.4); 4.2937 (0.4); 4.2829 (0.4); 4.2741 (0.3); 4.2516 (0.3); 4.2253 (0.4); 4.2146 (0.4); 4.2030 (0.4); 4.1922 (0.4); 3.9022 (0.4); 3.8850 (0.4); 3.8784 (0.4); 3.8612 (0.4); 3.8535 (0.3); 3.8313 (0.6); 3.8140 (0.6); 3.7908 (0.4); 3.7830 (0.4); 3.7659 (0.3); 3.1093 (1.3); 3.0840 (4.0); 3.0587 (4.2); 3.0334 (1.4); 1.6160 (16.0); 1.4348 (4.6); 1.4095 (9.6); 1.3841 (4.4); 1.2955 (1.4); 0.9393 (0.4); 0.9174 (1.2); 0.8943 (0.5); 0.1061 (1.9); 0.0354 (7.0)
I-161:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9499 (5.7); 7.9412 (5.7); 7.6323 (0.5); 7.6058 (3.2); 7.5990 (2.8); 7.5939 (3.1); 7.5876 (8.0); 7.5842 (7.9); 7.4838 (3.7); 7.4673 (0.7); 7.4518 (1.6); 7.4407 (2.2); 7.4341 (2.0); 7.4218 (1.6); 7.4139 (1.0); 7.3310 (3.6); 7.2986 (19.2); 7.0354 (4.0); 6.9266 (2.2); 6.8997 (1.9); 6.6942 (1.0); 6.6743 (2.0); 6.6542 (1.1); 6.5973 (5.9); 6.5885 (5.8); 5.0749 (1.5); 5.0680 (0.8); 5.0520 (2.7); 5.0311 (2.2); 4.1324 (1.4); 4.1112 (1.4); 4.0851 (3.0); 4.0708 (2.5); 4.0654 (4.2); 4.0436 (2.8); 4.0354 (2.1); 4.0282 (1.2); 4.0165 (1.7); 3.9865 (1.8); 3.9629 (2.5); 3.9416 (1.8); 3.9350 (1.4); 3.9143 (0.8); 2.4646 (12.0); 2.4577 (6.9); 2.4066 (0.5); 2.3834 (1.0); 2.3680 (1.0); 2.3615 (1.4); 2.3499 (1.2); 2.3418 (1.7); 2.3258 (1.0); 2.3170 (1.1); 2.3041 (0.7); 2.2708 (16.0); 2.1806 (0.5); 2.1568 (1.2); 2.1317 (1.7); 2.1244 (0.7); 2.1098 (2.1); 2.1047 (2.2); 2.0976 (2.2); 2.0869 (3.7); 2.0830 (3.5); 2.0692 (2.9); 2.0625 (2.3); 2.0465 (2.1); 2.0425 (1.6); 2.0384 (1.3); 2.0229 (0.6); 2.0125 (0.5); 1.6402 (1.9); 0.1085 (1.1); 0.0491 (0.9); 0.0383 (21.2); 0.0274 (0.9)
I-162:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5253 (0.4); 7.5075 (3.4); 7.4978 (4.6); 7.4256 (2.6); 7.3564 (1.0); 7.3480 (1.4); 7.3450 (1.3); 7.3392 (1.1); 7.3210 (2.2); 7.3050 (2.4); 7.2587 (3.3); 7.0324 (3.1); 6.9957 (0.7); 6.9845 (1.2); 6.9728 (0.7); 6.9553 (1.7); 6.9393 (1.5); 4.1950 (1.0); 4.1825 (1.0); 4.1652 (2.1); 4.1528 (2.0); 4.1354 (1.1); 4.1229 (1.1); 4.1137 (1.0); 4.0181 (16.0); 2.4590 (8.2); 2.3379 (0.7); 2.2896 (11.1); 2.1585 (0.6); 1.5743 (4.8); 1.2660 (0.8); 0.8955 (0.5); 0.8820 (1.0); 0.8679 (0.5); -0.0002 (3.0)
I-163:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9799 (1.5); 7.5488 (1.4); 7.5289 (6.5); 7.5140 (16.0); 7.5119 (14.5); 7.4470 (0.8); 7.4317 (2.3); 7.4159 (10.4); 7.3983 (4.5); 7.3761 (6.9); 7.3702 (4.4); 7.3600 (4.1); 7.3459 (7.0); 7.3261 (3.9); 7.2600 (56.7); 7.2464 (4.3); 7.1646 (2.3); 7.1442 (3.9); 7.1236 (1.8); 6.5222 (2.0); 6.5073 (3.6); 6.4919 (2.0); 4.6497 (0.3); 4.5149 (0.7); 4.4975 (0.7); 4.3857 (5.2); 4.3682 (15.9); 4.3507 (16.0); 4.3333 (5.1); 4.2019 (3.9); 4.1861 (3.9); 4.1652 (8.2); 4.1494 (7.8); 4.1284 (4.4); 4.1126 (3.9); 4.0892 (0.4); 2.9470 (10.5); 2.8625 (9.4); 1.5494 (70.5); 1.5197 (0.9); 1.5022 (0.6); 1.4779 (0.6); 1.4551 (16.4); 1.4377 (32.5); 1.4202 (15.8); 1.3975 (1.4); 1.3801 (0.8); 1.3637 (0.3); 1.2221 (0.6); -0.0002 (16.3)
I-164:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8915 (5.8); 7.8564 (0.4); 7.8389 (0.7); 7.8194 (0.4); 7.7230 (1.6); 7.7177 (1.4); 7.7127 (1.4); 7.7053 (3.5); 7.7019 (3.5); 7.6781 (1.8); 7.6749 (1.8); 7.5708 (1.6); 7.5210 (1.4); 7.5122 (0.9); 7.4995 (1.3); 7.4930 (4.0); 7.4819 (0.9); 7.4733 (0.6); 7.4625 (1.8); 7.4567 (1.6); 7.4343 (0.7); 7.4285 (0.7); 7.2984 (10.6); 4.5105 (0.9); 4.4901 (0.9); 4.4618 (1.9); 4.4414 (1.8); 4.4131 (1.0); 4.3927 (0.9); 2.8416 (16.0); 1.5919 (2.5); 0.1065 (0.5); 0.0471 (0.4); 0.0363 (10.2); 0.0253 (0.4)
I-165:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2909 (16.0); 7.8875 (4.3); 7.6128 (3.6); 7.5910 (5.8); 7.5693 (3.8); 7.4651 (8.1); 7.4365 (17.3); 7.3672 (3.6); 7.3443 (6.5); 7.3215 (4.8); 7.3000 (5.6); 7.2804 (7.2); 7.2748 (6.8); 7.2526 (5.6); 7.2468 (5.4); 7.2279 (4.9); 7.2007 (6.4); 7.1974 (6.3); 7.1736 (2.9); 7.1046 (0.4); 7.0795 (0.5); 7.0582 (0.4); 6.1365 (2.4); 6.1265 (2.7); 6.1142 (2.7); 6.1044 (2.4); 5.9817 (2.4); 5.9713 (2.7); 5.9595 (2.7); 5.9494 (2.3); 5.3341 (3.6); 4.3300 (1.2); 4.3200 (1.3); 4.3088 (1.4); 4.2979 (1.4); 4.2818 (1.7); 4.2710 (1.8); 4.2599 (1.8); 4.2483 (2.0); 4.2331 (1.5); 4.2219 (1.5); 4.2112 (1.4); 4.1948 (1.7); 4.1843 (1.8); 4.1731 (1.7); 4.1628 (1.6); 4.1426 (0.4); 4.1303 (0.4); 3.9437 (1.4); 3.9245 (2.0); 3.9031 (1.7); 3.8954 (1.6); 3.8715 (2.7); 3.8531 (2.8); 3.8295 (1.8); 3.8220 (1.6); 3.8012 (1.6); 3.7813 (1.1); 2.0786 (0.6); 1.6680 (0.9); 1.2907 (1.8); 1.0524 (0.4); 1.0342 (0.7); 1.0125 (0.6); 0.7945 (0.3); 0.0347 (3.3)
I-166:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1659 (1.4); 9.1462 (1.4); 7.8144 (6.0); 7.7284 (0.6); 7.7084 (1.7); 7.6893 (1.5); 7.6503 (2.0); 7.6299 (3.6); 7.5747 (1.4); 7.5535 (1.1); 7.4708 (0.6); 7.4658 (0.7); 7.4513 (0.7); 7.4461 (0.8); 7.4412 (0.8); 7.4359 (0.8); 7.4213 (0.7); 7.4163 (0.7); 7.3764 (0.6); 7.3552 (1.4); 7.3498 (0.8); 7.3342 (1.0); 7.3285 (1.4); 7.3076 (0.9); 7.2571 (0.8); 7.2466 (0.9); 7.2308 (0.6); 7.2255 (0.6); 5.1495 (0.8); 5.1314 (1.3); 5.1134 (0.8); 3.3666 (48.2); 2.8933 (0.9); 2.7345 (0.8); 2.6131 (16.0); 2.5161 (5.8); 2.5117 (12.5); 2.5072 (17.0); 2.5027 (12.4); 2.4983 (6.1); 1.4366 (6.4); 1.4191 (6.4)
I-167:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0837 (1.5); 9.0626 (1.5); 7.8219 (6.7); 7.7226 (0.6); 7.7029 (1.7); 7.6821 (1.5); 7.6425 (4.5); 7.6261 (1.1); 7.5989 (1.6); 7.5799 (1.0); 7.1683 (2.8); 7.0495 (1.0); 7.0300 (1.9); 6.9829 (2.8); 6.9633 (1.6); 5.1764 (0.4); 5.1627 (0.8); 5.1425 (0.8); 5.1288 (0.4); 4.7336 (0.4); 4.6959 (2.8); 4.6856 (2.7); 4.6483 (0.4); 4.0183 (1.1); 4.0066 (1.2); 3.9900 (1.4); 3.9783 (1.3); 3.7575 (1.3); 3.7420 (1.3); 3.7291 (1.1); 3.7138 (1.1); 3.3311 (27.6); 2.6030 (16.0); 2.5246 (0.6); 2.5112 (9.8); 2.5070 (19.0); 2.5025 (24.5); 2.4980 (17.6); 2.4937 (8.6); 2.0599 (11.1); 1.2404 (0.8)
I-168:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5200 (3.4); 7.5099 (3.7); 7.4944 (0.3); 7.4546 (2.9); 7.4375 (4.0); 7.4062 (2.2); 7.3579 (3.7); 7.3410 (2.8); 7.3209 (0.8); 7.3159 (0.9); 7.3108 (1.2); 7.3073 (1.1); 7.3029 (0.8); 7.2979 (0.7); 7.2602 (3.6); 7.1297 (0.5); 7.1182 (1.0); 7.1066 (0.6); 4.1419 (0.8); 4.1293 (0.9); 4.1126 (1.9); 4.1082 (1.4); 4.1001 (1.9); 4.0833 (1.1); 4.0708 (0.9); 4.0057 (16.0); 3.9933 (0.7); 1.5781 (3.2); 1.2553 (0.6); -0.0002 (3.2)
I-169:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5247 (0.4); 7.5053 (4.6); 7.4925 (5.4); 7.4160 (3.1); 7.4021 (0.5); 7.3922 (1.4); 7.3861 (1.2); 7.3801 (1.8); 7.3754 (1.5); 7.3698 (1.0); 7.3635 (0.7); 7.2588 (5.8); 7.2330 (4.0); 7.2129 (5.7); 7.1263 (5.1); 7.1064 (3.5); 6.6583 (1.8); 6.6289 (2.0); 6.6140 (2.1); 6.5846 (2.1); 6.3749 (1.4); 6.3548 (1.3); 6.0263 (4.0); 5.9820 (3.5); 5.7381 (3.9); 5.7086 (3.6); 5.3097 (0.4); 5.2921 (1.2); 5.2737 (1.6); 5.2553 (1.1); 2.3201 (16.0); 2.2805 (0.5); 2.2736 (0.5); 1.5718 (8.8); 1.5591 (9.4); 1.5418 (9.2); 1.2648 (0.8); 0.8982 (0.4); 0.8817 (1.0); 0.8640 (0.4); -0.0002 (3.6)
I-170:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.8246 (0.8); 8.8102 (1.6); 8.7960 (0.8); 8.0999 (9.2); 7.7559 (0.7); 7.7366 (2.1); 7.7169 (2.2); 7.7042 (2.5); 7.6841 (0.9); 7.6498 (2.8); 7.5863 (1.6); 7.5668 (1.3); 7.5472 (3.3); 7.4247 (1.0); 7.4049 (2.4); 7.4011 (2.4); 7.3767 (4.0); 7.3569 (1.7); 3.5764 (1.0); 3.5594 (2.6); 3.5441 (2.6); 3.5268 (1.1); 3.3228 (107.8); 2.9392 (1.9); 2.9218 (3.8); 2.9040 (1.8); 2.6752 (0.6); 2.6706 (0.8); 2.6661 (0.6); 2.5408 (66.4); 2.5238 (2.0); 2.5189 (2.9); 2.5102 (55.7); 2.5059 (117.5); 2.5015 (157.9); 2.4970 (112.4); 2.4926 (53.1); 2.3524 (0.4); 2.3367 (16.0); 1.2346 (0.4); 0.0079 (0.4); -0.0003 (14.6); -0.0083 (0.5)
I-171:1 H-NMR(300.2 MHz, CDCl3): δ= 9.3983 (0.6); 8.3454 (4.9); 7.6200 (1.8); 7.6159 (1.6); 7.6105 (1.4); 7.6024 (3.6); 7.5993 (3.8); 7.4677 (1.9); 7.4542 (0.4); 7.4394 (0.8); 7.4273 (1.1); 7.4205 (0.9); 7.4096 (0.8); 7.4016 (0.5); 7.3541 (1.8); 7.3275 (2.1); 7.2983 (6.8); 7.0687 (2.1); 6.9356 (1.1); 6.9092 (1.0); 4.7075 (1.1); 4.6904 (1.0); 4.6593 (2.2); 4.6421 (2.2); 4.6110 (1.1); 4.5939 (1.1); 2.7610 (16.0); 2.5037 (6.3); 2.4965 (3.5); 2.3094 (8.4); 2.0818 (1.0); 1.5964 (1.7); 1.3207 (0.3); 1.2968 (1.0); 0.1094 (0.3); 0.0388 (7.2)
I-172:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1274 (3.2); 8.0424 (0.5); 7.6674 (1.3); 7.6494 (0.4); 7.6226 (1.0); 7.5962 (0.8); 7.5275 (0.9); 7.4972 (1.2); 7.4687 (2.1); 7.4359 (1.2); 7.4308 (1.1); 7.4096 (1.4); 7.3712 (0.7); 7.3437 (0.6); 7.3047 (9.1); 6.9326 (0.7); 6.7450 (1.4); 6.5574 (0.7); 5.3438 (0.7); 4.4997 (0.6); 4.4793 (0.6); 4.4520 (1.3); 4.4314 (1.3); 4.4042 (0.7); 4.3838 (0.6); 2.7607 (9.7); 2.0892 (0.6); 2.0515 (0.8); 1.6051 (16.0); 1.3031 (0.6); 0.0535 (0.3); 0.0428 (8.1)
I-173:1 H-NMR(400.1 MHz, CDCl3): δ= 8.6831 (5.1); 8.6788 (4.9); 8.4906 (4.8); 8.4848 (4.7); 8.2775 (11.7); 8.0155 (1.2); 7.8072 (3.5); 7.8017 (5.0); 7.7965 (3.2); 7.7431 (1.4); 7.3354 (3.5); 7.3154 (3.9); 7.2601 (45.4); 7.0519 (4.1); 6.9961 (0.4); 6.9806 (2.2); 6.9615 (2.0); 4.2545 (1.9); 4.2397 (1.8); 4.2183 (3.9); 4.2035 (3.7); 4.1821 (2.0); 4.1673 (1.8); 2.9551 (8.7); 2.8821 (7.7); 2.4727 (11.7); 2.3057 (16.0); 1.5505 (26.7); -0.0002 (2.4)
I-174:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9765 (2.3); 7.5521 (1.4); 7.5325 (6.6); 7.5175 (15.4); 7.5155 (14.0); 7.4972 (9.7); 7.4757 (13.7); 7.4501 (1.0); 7.4177 (7.6); 7.3926 (13.4); 7.3712 (9.5); 7.3631 (3.8); 7.3552 (4.7); 7.3497 (3.6); 7.3393 (3.4); 7.3340 (2.1); 7.2601 (50.0); 6.5519 (2.0); 6.5370 (3.4); 6.5220 (1.9); 4.6377 (0.3); 4.6200 (0.4); 4.4915 (0.6); 4.4740 (0.7); 4.3562 (4.6); 4.3388 (14.5); 4.3213 (14.6); 4.3039 (4.6); 4.1942 (3.4); 4.1783 (3.4); 4.1577 (7.2); 4.1419 (6.9); 4.1212 (3.7); 4.1054 (3.4); 2.9467 (16.0); 2.8611 (14.4); 1.5522 (58.4); 1.5245 (0.6); 1.5067 (0.9); 1.4891 (0.5); 1.4768 (0.3); 1.4445 (14.8); 1.4271 (29.4); 1.4096 (14.2); 1.3851 (1.3); 1.3675 (0.7); -0.0002 (14.7)
I-175:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2980 (0.6); 8.2885 (16.0); 8.0328 (1.0); 8.0128 (1.5); 7.4742 (4.5); 7.4462 (6.0); 7.4387 (3.9); 7.4338 (4.8); 7.4280 (3.8); 7.2985 (26.9); 7.2550 (3.6); 7.2481 (3.4); 7.2270 (2.9); 7.2202 (2.7); 7.2052 (1.0); 7.1776 (6.2); 7.1601 (6.9); 7.1550 (6.2); 7.1470 (3.6); 7.1280 (0.9); 7.1198 (0.4); 6.9473 (0.4); 6.9337 (1.6); 6.9181 (2.4); 6.9116 (1.8); 6.9027 (2.6); 6.8880 (1.4); 6.8798 (1.2); 6.1490 (1.1); 6.1381 (1.2); 6.1269 (1.2); 6.1161 (1.1); 5.9946 (1.1); 5.9837 (1.2); 5.9725 (1.2); 5.9618 (1.1); 4.3347 (0.6); 4.3237 (0.7); 4.3130 (0.6); 4.3019 (0.7); 4.2860 (0.8); 4.2750 (0.9); 4.2642 (0.8); 4.2529 (1.1); 4.2395 (0.6); 4.2287 (0.7); 4.2177 (0.7); 4.2017 (0.9); 4.1906 (0.8); 4.1799 (0.9); 4.1690 (0.8); 3.9672 (0.8); 3.9493 (1.0); 3.9456 (1.0); 3.9275 (0.9); 3.9186 (0.7); 3.9005 (0.8); 3.8966 (0.9); 3.8911 (1.0); 3.8787 (0.8); 3.8732 (1.1); 3.8695 (1.0); 3.8515 (0.8); 3.8424 (0.8); 3.8244 (0.8); 3.8206 (0.8); 3.8026 (0.6); 2.1946 (0.5); 2.1774 (1.1); 2.1663 (1.2); 2.1491 (2.2); 2.1317 (1.3); 2.1208 (1.2); 2.1032 (0.6); 1.5830 (15.7); 1.4704 (0.4); 1.1190 (1.6); 1.1037 (4.3); 1.0969 (4.6); 1.0910 (2.3); 1.0820 (2.4); 1.0751 (4.5); 1.0686 (4.1); 1.0538 (2.1); 0.8550 (2.2); 0.8399 (5.1); 0.8339 (4.7); 0.8229 (4.4); 0.8175 (5.4); 0.8009 (1.6); 0.1080 (0.6); 0.0489 (1.2); 0.0382 (33.6); 0.0272 (1.1)
I-176:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1496 (5.0); 8.0688 (0.7); 7.6258 (0.6); 7.5998 (1.5); 7.5734 (1.2); 7.5092 (1.4); 7.4835 (0.8); 7.4032 (1.7); 7.3717 (2.6); 7.3450 (2.7); 7.2987 (5.7); 7.0660 (1.9); 6.9800 (1.0); 6.9535 (0.9); 6.9145 (1.1); 6.7268 (2.2); 6.5391 (1.1); 4.3061 (1.0); 4.2863 (1.0); 4.2580 (2.2); 4.2382 (2.1); 4.2099 (1.1); 4.1901 (1.1); 4.1714 (0.6); 4.1476 (0.6); 2.7536 (16.0); 2.5191 (3.2); 2.5120 (5.9); 2.5046 (3.2); 2.3149 (8.0); 2.0826 (2.6); 1.6068 (2.3); 1.3210 (0.7); 1.2971 (1.6); 1.2733 (0.7); 0.0384 (7.0)
I-177:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9869 (0.5); 7.5423 (0.5); 7.5225 (2.3); 7.5073 (5.9); 7.4239 (3.0); 7.4017 (0.5); 7.3974 (0.4); 7.3890 (1.3); 7.3821 (2.2); 7.3767 (1.7); 7.3659 (1.6); 7.3505 (3.8); 7.3263 (3.1); 7.3228 (3.1); 7.3038 (2.7); 7.2851 (1.4); 7.2598 (20.7); 6.4753 (0.8); 6.4599 (1.3); 6.4447 (0.7); 4.3815 (1.8); 4.3641 (5.7); 4.3466 (5.8); 4.3292 (1.8); 4.1971 (1.4); 4.1815 (1.4); 4.1601 (2.9); 4.1445 (2.8); 4.1230 (1.5); 4.1074 (1.4); 2.9479 (3.6); 2.8663 (3.2); 2.4158 (0.7); 2.3841 (0.5); 2.3653 (16.0); 1.5489 (27.9); 1.4471 (5.9); 1.4296 (11.8); 1.4122 (5.8); 1.3961 (0.5); -0.0002 (5.8)
I-178:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2807 (4.5); 8.0898 (0.4); 8.0704 (0.7); 8.0507 (0.4); 7.6673 (1.8); 7.5729 (0.8); 7.5468 (2.0); 7.5204 (1.5); 7.5034 (1.3); 7.4752 (2.8); 7.4626 (1.6); 7.4368 (2.3); 7.4088 (0.6); 7.4036 (0.6); 7.2993 (12.7); 7.1599 (0.9); 7.1539 (0.9); 7.1331 (0.8); 7.1276 (0.8); 5.3387 (1.2); 5.1788 (2.1); 5.1585 (2.5); 5.1514 (2.4); 5.1310 (2.5); 4.8374 (2.3); 4.8162 (4.3); 4.7953 (2.3); 4.4871 (0.8); 4.4665 (0.8); 4.4388 (1.8); 4.4184 (1.7); 4.3908 (0.9); 4.3704 (0.9); 4.3248 (0.6); 4.3203 (0.6); 4.2976 (1.0); 4.2755 (0.5); 4.2709 (0.5); 1.5999 (16.0); 0.1069 (1.4); 0.0469 (0.5); 0.0373 (12.0); 0.0266 (0.5)
I-179:1 H-NMR(499.9 MHz, CDCl3): δ= 8.0565 (5.7); 7.9632 (0.7); 7.9519 (1.1); 7.9405 (0.6); 7.6221 (2.8); 7.4657 (1.4); 7.4644 (1.4); 7.4496 (1.9); 7.4483 (2.0); 7.4388 (1.9); 7.4218 (3.7); 7.3949 (2.2); 7.3918 (2.2); 7.3777 (1.3); 7.3717 (2.4); 7.3676 (3.2); 7.3637 (2.1); 7.3579 (1.9); 7.3415 (3.1); 7.3253 (1.6); 7.2669 (1.2); 7.1463 (1.6); 7.1433 (1.5); 7.1299 (1.3); 7.1269 (1.3); 4.4183 (1.1); 4.4060 (1.1); 4.3897 (2.3); 4.3773 (2.2); 4.3610 (1.2); 4.3487 (1.1); 2.7086 (16.0); 2.0409 (1.0); 1.6830 (0.6); 1.2566 (0.6); -0.0002 (1.2)
I-180:1 H-NMR(400.0 MHz, CD3CN): δ= 7.8047 (0.9); 7.7539 (7.5); 7.6864 (0.8); 7.6667 (2.4); 7.6471 (2.3); 7.6322 (2.9); 7.6127 (1.1); 7.5321 (3.2); 7.4593 (1.9); 7.4397 (1.5); 7.3321 (2.9); 7.3122 (3.1); 7.0607 (4.0); 6.9459 (1.9); 6.9261 (1.7); 4.1873 (1.6); 4.1711 (1.6); 4.1515 (3.3); 4.1354 (3.2); 4.1157 (1.7); 4.0996 (1.6); 3.8426 (3.6); 3.6402 (0.9); 3.1357 (0.4); 3.1197 (0.4); 2.4413 (9.6); 2.2787 (0.7); 2.2660 (1.0); 2.2578 (1.2); 2.2453 (2.0); 2.2317 (14.3); 2.2127 (0.8); 2.1577 (16.6); 2.1417 (17.5); 1.9714 (0.6); 1.9633 (0.6); 1.9516 (7.4); 1.9455 (13.6); 1.9394 (18.7); 1.9332 (13.2); 1.9271 (7.0); 1.7429 (0.4); 1.7309 (0.5); 1.7171 (0.5); 1.6699 (0.4); 1.6578 (0.5); 1.6443 (0.4); 1.4356 (16.0); 1.2724 (0.5); 1.2553 (0.4); 1.2194 (0.6); 1.2102 (1.6); 1.2034 (0.9); 1.1930 (1.6); 1.1145 (0.7); 1.1100 (0.7); 1.1019 (2.0); 1.0955 (3.4); 1.0879 (1.9); 1.0810 (2.3); 1.0750 (3.0); 1.0674 (1.8); 1.0546 (0.7); 1.0461 (1.6); 1.0375 (3.6); 1.0330 (3.4); 1.0260 (3.4); 1.0198 (2.7); 1.0071 (0.8); 0.9215 (0.3); 0.9048 (0.4); -0.0002 (9.2)
I-181:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9885 (1.3); 7.5438 (0.7); 7.5242 (2.9); 7.5080 (7.9); 7.4929 (0.7); 7.4353 (4.0); 7.4080 (0.5); 7.3943 (1.7); 7.3880 (2.7); 7.3825 (2.0); 7.3711 (2.0); 7.3621 (3.7); 7.3419 (3.8); 7.2599 (23.8); 7.0818 (0.4); 7.0503 (4.2); 6.9890 (2.3); 6.9690 (2.0); 6.5176 (1.0); 6.5027 (1.8); 6.4880 (1.0); 4.5058 (0.3); 4.4882 (0.3); 4.3845 (2.4); 4.3670 (7.5); 4.3496 (7.6); 4.3321 (2.4); 4.2272 (1.7); 4.2115 (1.7); 4.1899 (3.7); 4.1743 (3.5); 4.1527 (1.9); 4.1370 (1.7); 2.9483 (9.3); 2.8677 (8.2); 2.4788 (11.8); 2.3487 (0.7); 2.3257 (0.5); 2.2972 (16.0); 1.5530 (28.3); 1.5169 (0.3); 1.4487 (7.7); 1.4313 (15.4); 1.4138 (7.5); 1.3984 (0.7); 1.3807 (0.4); -0.0002 (7.0)
I-182:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1604 (3.1); 8.0338 (16.0); 7.9610 (0.6); 7.6695 (2.0); 7.6497 (4.7); 7.6299 (3.3); 7.5888 (6.4); 7.5676 (11.1); 7.5400 (4.4); 7.5117 (11.8); 7.4902 (7.0); 7.4657 (6.0); 7.4219 (3.4); 7.4015 (2.9); 7.2465 (2.7); 7.1073 (5.9); 6.9681 (2.9); 4.1496 (1.4); 4.1361 (1.6); 4.1151 (3.2); 4.1013 (3.2); 4.0803 (1.9); 4.0666 (1.7); 3.3119 (34.8); 2.8986 (3.6); 2.7399 (3.3); 2.5131 (13.7); 2.5088 (18.4); 2.5046 (14.0)
I-183:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7255 (5.4); 7.6072 (0.4); 7.5808 (2.0); 7.5719 (1.9); 7.5618 (4.8); 7.5588 (4.5); 7.5329 (2.6); 7.5043 (3.3); 7.4965 (2.7); 7.4929 (2.5); 7.4904 (2.5); 7.4752 (0.4); 7.4173 (2.4); 7.3953 (0.4); 7.3800 (1.1); 7.3689 (1.4); 7.3619 (1.3); 7.3492 (1.1); 7.3415 (0.6); 7.2986 (1.5); 7.1846 (2.1); 7.1784 (2.1); 7.1571 (2.2); 7.1501 (1.7); 7.1412 (0.8); 4.4198 (1.0); 4.3985 (1.0); 4.3717 (2.1); 4.3504 (2.1); 4.3235 (1.1); 4.3022 (1.0); 2.3096 (16.0); 2.2837 (1.0); 1.7875 (0.6); 1.2912 (0.4); 0.0328 (1.4)
I-184:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0414 (1.2); 9.0214 (1.2); 7.9532 (0.5); 7.7818 (6.2); 7.7216 (0.6); 7.7014 (1.7); 7.6810 (1.4); 7.6414 (2.9); 7.6355 (2.6); 7.6298 (2.0); 7.5670 (1.3); 7.5468 (1.0); 6.9734 (3.0); 6.9694 (3.3); 6.8683 (1.1); 6.8646 (1.0); 6.8482 (2.1); 6.8442 (2.1); 6.8093 (4.3); 6.7893 (2.2); 5.9561 (3.9); 5.9539 (5.4); 5.9451 (5.0); 5.9429 (4.4); 5.0732 (0.8); 5.0547 (1.2); 5.0363 (0.8); 3.3536 (18.8); 3.3480 (20.0); 2.8908 (3.7); 2.7324 (3.2); 2.6043 (16.0); 2.5130 (5.3); 2.5086 (11.2); 2.5041 (15.0); 2.4995 (10.8); 2.4951 (5.2); 1.4067 (6.1); 1.3893 (6.0); -0.0002 (0.3)
I-185:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3113 (9.3); 8.1070 (0.7); 8.0894 (1.1); 8.0705 (0.7); 7.5727 (1.5); 7.5466 (3.8); 7.5202 (2.8); 7.4553 (5.0); 7.4279 (7.9); 7.2989 (14.4); 7.2313 (2.5); 7.2243 (2.2); 7.2035 (1.8); 7.1966 (1.9); 7.1769 (1.7); 7.1737 (1.8); 7.1691 (1.6); 7.1659 (1.5); 7.1502 (1.5); 7.1469 (1.5); 7.1424 (1.4); 7.1392 (1.2); 6.1397 (0.8); 6.1290 (0.8); 6.1164 (0.8); 6.1057 (0.8); 5.9845 (0.8); 5.9740 (0.8); 5.9613 (0.8); 5.9507 (0.8); 5.3371 (3.1); 5.1756 (4.0); 5.1553 (4.8); 5.1480 (4.6); 5.1277 (4.8); 4.8371 (2.6); 4.8316 (2.6); 4.8160 (4.6); 4.8106 (4.6); 4.7950 (2.5); 4.7895 (2.4); 4.3588 (0.5); 4.3465 (0.7); 4.3364 (0.6); 4.3234 (1.3); 4.3175 (1.1); 4.3102 (0.8); 4.2955 (2.0); 4.2887 (1.1); 4.2699 (1.3); 4.2594 (0.6); 4.2472 (0.8); 4.2367 (0.5); 4.2212 (0.6); 4.2104 (0.5); 4.1988 (0.6); 4.1881 (0.5); 3.9036 (0.5); 3.8868 (0.6); 3.8804 (0.6); 3.8634 (0.6); 3.8550 (0.5); 3.8375 (0.6); 3.8317 (1.0); 3.8148 (1.0); 3.8088 (0.6); 3.7916 (0.6); 3.7831 (0.5); 3.7661 (0.5); 3.7598 (0.5); 3.7428 (0.4); 1.6152 (16.0); 1.2907 (0.3); 0.1066 (4.9); 0.0469 (0.5); 0.0363 (12.0); 0.0254 (0.5)
I-186:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5591 (1.1); 7.5369 (3.4); 7.5151 (0.4); 7.4789 (1.6); 7.4440 (0.8); 7.4350 (1.2); 7.4276 (0.8); 7.4190 (1.9); 7.4056 (0.5); 7.3922 (1.7); 7.3164 (0.5); 7.2984 (10.3); 7.2772 (0.5); 7.0800 (1.7); 7.0266 (0.9); 7.0003 (0.8); 5.3374 (0.4); 5.1145 (0.4); 5.1063 (0.5); 5.0931 (0.5); 5.0852 (0.6); 5.0801 (0.5); 5.0668 (0.5); 5.0586 (0.4); 4.2888 (0.4); 4.2678 (0.4); 4.2355 (0.7); 4.2142 (0.7); 4.1847 (0.6); 4.1645 (0.8); 4.1312 (0.4); 4.1112 (0.4); 3.7565 (1.0); 3.7300 (1.0); 3.7196 (1.3); 3.6931 (1.2); 3.4962 (1.2); 3.4877 (1.3); 3.4593 (1.0); 3.4509 (0.9); 3.4197 (0.3); 3.4109 (0.3); 3.3444 (16.0); 2.5297 (5.0); 2.5225 (2.9); 2.3066 (6.7); 2.0441 (10.0); 1.6074 (4.0); 1.4618 (6.4); 1.4405 (6.3); 0.0478 (0.4); 0.0371 (9.8); 0.0261 (0.4)
I-187:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2772 (13.9); 8.0239 (0.8); 8.0060 (1.3); 7.9891 (0.8); 7.3858 (3.6); 7.3592 (4.1); 7.2985 (15.1); 7.1914 (0.8); 7.1637 (3.6); 7.1552 (2.7); 7.1429 (7.4); 7.1346 (2.5); 7.1273 (2.9); 7.1074 (0.9); 7.1001 (0.5); 7.0647 (3.8); 6.9806 (2.1); 6.9541 (1.8); 6.9253 (1.3); 6.9129 (1.3); 6.9039 (2.0); 6.8948 (2.0); 6.8785 (1.2); 6.8714 (1.1); 4.3034 (2.0); 4.2835 (2.0); 4.2560 (4.4); 4.2359 (4.2); 4.2084 (2.2); 4.1885 (2.1); 2.5212 (6.3); 2.5142 (11.7); 2.5066 (6.4); 2.3101 (16.0); 2.1942 (0.4); 2.1767 (0.9); 2.1656 (1.0); 2.1486 (1.9); 2.1315 (1.0); 2.1203 (1.0); 2.1026 (0.6); 1.5882 (7.2); 1.1174 (1.4); 1.1021 (3.6); 1.0953 (3.8); 1.0894 (2.0); 1.0804 (2.1); 1.0735 (3.8); 1.0669 (3.4); 1.0522 (1.8); 0.8535 (1.8); 0.8384 (4.2); 0.8323 (4.0); 0.8214 (3.7); 0.8159 (4.6); 0.7993 (1.4); 0.0498 (0.6); 0.0465 (0.4); 0.0390 (18.9); 0.0313 (0.5); 0.0281 (0.6)
I-188:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.8469 (0.8); 8.8328 (1.6); 8.8187 (0.8); 7.9597 (2.2); 7.7449 (0.6); 7.7256 (1.9); 7.7060 (1.9); 7.6914 (2.4); 7.6721 (1.0); 7.5923 (2.6); 7.5341 (1.5); 7.5146 (1.3); 6.9382 (2.2); 6.9180 (2.6); 6.6562 (3.6); 6.6101 (2.7); 6.5899 (2.5); 3.8206 (16.0); 3.6089 (0.8); 3.5923 (2.2); 3.5769 (2.4); 3.5608 (1.0); 3.3391 (102.1); 2.9644 (1.6); 2.9474 (3.2); 2.9305 (1.6); 2.8975 (12.7); 2.7382 (11.6); 2.5092 (11.3); 2.5053 (8.7); 2.4163 (12.2); 2.2342 (14.2)
I-189:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9343 (0.5); 7.6545 (1.2); 7.3850 (3.5); 7.3583 (4.0); 7.2987 (18.2); 7.1249 (0.9); 7.0984 (2.9); 7.0718 (9.7); 7.0636 (3.7); 7.0487 (2.0); 7.0427 (2.5); 7.0217 (1.0); 7.0156 (0.8); 6.9822 (2.1); 6.9560 (1.9); 6.8512 (1.3); 6.8432 (1.3); 6.8284 (2.3); 6.8219 (1.9); 6.8033 (1.2); 6.7973 (1.1); 5.0611 (0.5); 5.0403 (1.0); 5.0176 (1.6); 4.9996 (5.9); 4.9961 (5.6); 4.9789 (6.2); 4.9579 (2.1); 4.6461 (3.0); 4.6316 (4.6); 4.6258 (4.8); 4.6086 (2.5); 4.2570 (1.8); 4.2369 (1.7); 4.2094 (3.9); 4.1891 (3.8); 4.1616 (2.0); 4.1414 (1.9); 2.5208 (11.7); 2.5137 (6.7); 2.3230 (16.0); 2.1651 (0.4); 2.1477 (0.9); 2.1366 (1.0); 2.1195 (1.8); 2.1025 (1.1); 2.0914 (1.0); 2.0835 (0.8); 2.0738 (0.5); 1.5925 (14.5); 1.3458 (0.5); 1.3064 (3.3); 1.2741 (0.4); 1.0859 (1.3); 1.0705 (3.4); 1.0638 (3.8); 1.0490 (2.0); 1.0419 (3.7); 1.0353 (3.5); 1.0208 (1.7); 0.9429 (1.2); 0.9211 (3.8); 0.8978 (1.4); 0.8234 (1.7); 0.8083 (4.2); 0.8024 (4.1); 0.7914 (3.7); 0.7856 (4.5); 0.7693 (1.3); 0.1090 (0.6); 0.0499 (0.8); 0.0391 (22.3); 0.0282 (0.8)
I-190:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1441 (2.4); 8.0166 (0.4); 7.5170 (0.4); 7.5137 (0.5); 7.5112 (0.5); 7.5080 (0.4); 7.4904 (0.6); 7.4871 (0.7); 7.4846 (0.8); 7.4814 (0.6); 7.4115 (0.8); 7.4046 (1.9); 7.3985 (0.8); 7.3766 (2.0); 7.3494 (1.5); 7.3038 (8.4); 7.2147 (0.6); 7.2115 (0.6); 7.2071 (0.6); 7.2040 (0.5); 7.1875 (0.5); 7.1844 (0.5); 7.1799 (0.4); 7.1768 (0.4); 7.0778 (1.0); 6.9985 (0.6); 6.9717 (0.5); 5.3428 (2.3); 4.3033 (0.5); 4.2835 (0.5); 4.2555 (1.0); 4.2356 (1.0); 4.2075 (0.5); 4.1877 (0.5); 2.7602 (7.6); 2.5163 (3.0); 2.5092 (1.7); 2.3382 (4.2); 2.0885 (0.7); 2.0508 (0.7); 1.6081 (16.0); 1.3021 (0.6); 0.1119 (0.4); 0.0422 (7.0)
I-191:1 H-NMR(499.9 MHz, CDCl3): δ= 8.1024 (5.1); 8.0138 (0.5); 7.8352 (1.0); 7.5941 (0.8); 7.5801 (1.5); 7.5689 (1.3); 7.5568 (1.6); 7.5422 (1.0); 7.3656 (1.1); 7.3487 (2.0); 7.3436 (2.6); 7.3275 (2.6); 7.2604 (4.3); 7.0233 (2.8); 6.9394 (1.5); 6.9235 (1.4); 4.2545 (1.1); 4.2426 (1.1); 4.2259 (2.3); 4.2140 (2.2); 4.1973 (1.2); 4.1854 (1.1); 2.9527 (3.1); 2.8804 (3.0); 2.7191 (16.0); 2.4769 (7.9); 2.2929 (0.4); 2.2570 (11.2); 2.1325 (0.4); 1.5894 (1.9); -0.0002 (3.8)
I-192:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9952 (1.4); 7.6834 (0.7); 7.6424 (8.4); 7.5969 (0.4); 7.5661 (1.5); 7.5468 (5.4); 7.5295 (15.7); 7.4741 (6.6); 7.4527 (11.3); 7.4430 (8.0); 7.3769 (10.4); 7.3598 (6.8); 7.2599 (87.6); 6.9960 (0.4); 6.4446 (2.0); 6.4293 (3.5); 6.4151 (1.8); 4.6766 (0.3); 4.5385 (0.4); 4.5204 (0.8); 4.5034 (0.8); 4.4853 (0.4); 4.4086 (3.5); 4.3942 (6.8); 4.3773 (15.1); 4.3718 (9.0); 4.3598 (16.0); 4.3424 (5.4); 4.3344 (3.9); 4.3184 (3.4); 2.9510 (9.9); 2.8715 (9.2); 1.5439 (103.2); 1.5034 (0.6); 1.4686 (14.0); 1.4512 (27.8); 1.4337 (13.6); 1.4107 (1.8); 1.4021 (0.7); 1.3928 (0.9); 1.3726 (0.3); -0.0002 (25.5)
I-193:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1140 (5.0); 7.8807 (0.4); 7.8608 (0.7); 7.8413 (0.4); 7.6673 (2.1); 7.6641 (2.2); 7.6324 (1.1); 7.6131 (1.6); 7.5908 (0.8); 7.5144 (1.4); 7.4861 (3.3); 7.4493 (1.8); 7.4434 (1.7); 7.4321 (0.9); 7.4211 (0.8); 7.4150 (0.8); 7.4044 (1.2); 7.3781 (0.5); 7.2983 (9.8); 4.5083 (1.0); 4.4875 (1.0); 4.4611 (2.1); 4.4403 (2.1); 4.4139 (1.1); 4.3931 (1.0); 2.7584 (16.0); 1.5960 (4.6); 1.2273 (0.7); 0.0473 (0.4); 0.0364 (10.1); 0.0255 (0.3)
I-194:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9942 (0.8); 8.9798 (1.6); 8.9651 (0.8); 7.7577 (3.4); 7.7373 (6.3); 7.6417 (1.0); 7.6220 (2.2); 7.6023 (1.4); 7.5314 (0.9); 7.5272 (0.9); 7.5103 (2.8); 7.5059 (3.4); 7.4902 (4.6); 7.4811 (1.6); 7.4693 (1.5); 7.4359 (2.6); 7.3976 (1.5); 7.3772 (1.3); 7.2304 (1.3); 7.0911 (2.7); 6.9519 (1.3); 6.0445 (0.5); 6.0322 (1.0); 6.0189 (0.6); 5.9288 (0.5); 5.9166 (1.0); 5.9036 (0.6); 3.8826 (0.8); 3.8705 (1.6); 3.8560 (1.0); 3.8298 (0.7); 3.8235 (0.7); 3.8143 (1.3); 3.7990 (0.8); 3.3116 (13.4); 2.8986 (1.1); 2.7397 (1.0); 2.6030 (16.0); 2.5131 (6.4); 2.5088 (8.6); 2.5046 (6.5)
I-195:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0301 (1.2); 9.0097 (1.3); 7.9524 (0.7); 7.7712 (5.7); 7.7285 (0.6); 7.7090 (1.6); 7.6895 (1.3); 7.6518 (4.5); 7.6322 (1.1); 7.5730 (1.4); 7.5540 (1.0); 7.2498 (2.5); 7.1024 (1.2); 7.0990 (1.2); 7.0819 (1.3); 7.0786 (1.4); 6.6523 (2.8); 6.6318 (2.6); 5.0833 (0.8); 5.0646 (1.2); 5.0463 (0.8); 4.4758 (2.1); 4.4542 (4.0); 4.4321 (2.4); 3.3640 (21.8); 3.3531 (26.5); 3.3509 (26.3); 3.0677 (0.4); 3.0500 (0.8); 3.0290 (1.3); 3.0191 (0.8); 3.0074 (0.7); 2.9971 (1.4); 2.9756 (0.7); 2.9581 (0.4); 2.8906 (4.8); 2.7318 (4.2); 2.6011 (16.0); 2.5124 (6.9); 2.5080 (14.9); 2.5035 (20.2); 2.4990 (14.8); 2.4946 (7.3); 1.4113 (6.1); 1.3939 (6.0); 1.2406 (0.4)
I-196:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1857 (5.0); 8.0635 (0.4); 8.0452 (0.6); 8.0286 (0.4); 7.6619 (1.2); 7.6412 (3.6); 7.6247 (0.5); 7.5846 (2.1); 7.5431 (1.6); 7.4791 (0.7); 7.4700 (1.2); 7.4627 (0.8); 7.4570 (0.5); 7.4485 (0.8); 7.4412 (0.5); 7.4248 (0.3); 7.3967 (2.7); 7.3908 (4.9); 7.3616 (0.3); 7.2990 (8.8); 6.1314 (0.5); 6.1208 (0.5); 6.1076 (0.5); 6.0970 (0.5); 5.9759 (0.5); 5.9652 (0.5); 5.9520 (0.5); 5.9415 (0.5); 3.8814 (0.4); 3.8746 (0.3); 3.8577 (0.4); 3.8270 (0.5); 3.8100 (0.5); 3.8042 (0.3); 3.1100 (1.1); 3.0847 (3.4); 3.0594 (3.4); 3.0341 (1.2); 1.6122 (16.0); 1.4356 (3.8); 1.4104 (8.0); 1.3850 (3.7); 1.2948 (1.4); 0.9396 (0.4); 0.9180 (1.3); 0.8948 (0.5); 0.1065 (2.1); 0.0361 (7.5)
I-197:1 H-NMR(499.9 MHz, CDCl3): δ= 7.3380 (2.8); 7.3312 (1.4); 7.3221 (3.1); 7.3153 (1.5); 7.2593 (5.9); 7.0583 (0.5); 7.0456 (0.8); 7.0283 (8.5); 7.0181 (3.6); 7.0141 (5.5); 7.0020 (0.5); 6.9984 (0.6); 6.9612 (2.0); 6.9450 (2.2); 6.9283 (1.0); 6.7605 (1.4); 6.7553 (1.3); 6.7518 (1.2); 6.7471 (2.1); 6.7415 (1.8); 6.7286 (1.0); 5.2199 (0.3); 5.2103 (1.1); 5.2006 (1.1); 5.1910 (0.4); 5.0635 (0.8); 5.0539 (2.6); 5.0443 (2.7); 5.0347 (0.9); 4.3597 (0.4); 4.3529 (0.4); 4.3451 (0.5); 4.3383 (0.5); 4.3157 (0.4); 4.3059 (0.8); 4.3001 (1.1); 4.2954 (1.1); 4.2906 (1.2); 4.2846 (0.9); 4.2751 (0.5); 4.1835 (0.8); 4.1772 (0.9); 4.1709 (1.3); 4.1660 (1.6); 4.1608 (1.3); 4.1532 (1.2); 4.1475 (1.9); 4.1432 (1.8); 4.1347 (1.7); 4.1304 (2.3); 4.1172 (1.6); 4.1045 (0.9); 4.1004 (1.2); 4.0866 (0.5); 3.9612 (1.5); 3.9441 (2.5); 3.9293 (1.8); 3.8371 (1.9); 3.8282 (1.9); 3.8198 (1.5); 3.8108 (1.4); 3.6290 (0.6); 3.6196 (1.0); 3.6126 (0.9); 3.6024 (1.0); 3.5955 (1.4); 3.5891 (1.7); 3.5760 (1.0); 3.5718 (0.9); 3.5584 (0.7); 3.5425 (0.4); 3.5335 (0.4); 3.5275 (0.4); 3.5177 (0.4); 3.4598 (0.7); 3.4492 (1.2); 3.4385 (0.8); 3.4335 (0.7); 3.4224 (0.9); 3.4119 (0.5); 2.4612 (11.8); 2.3337 (0.4); 2.2958 (16.0); 2.0864 (0.5); 2.0760 (1.0); 2.0692 (1.2); 2.0591 (2.1); 2.0489 (1.3); 2.0423 (1.2); 2.0318 (0.6); 1.9975 (1.6); 1.4670 (10.5); 1.4574 (10.6); 1.3989 (4.4); 1.3892 (4.5); 1.2558 (0.6); 1.0057 (1.2); 0.9959 (3.7); 0.9927 (3.9); 0.9790 (3.7); 0.9759 (3.7); 0.9668 (1.4); 0.7506 (1.5); 0.7406 (4.7); 0.7386 (4.8); 0.7311 (4.2); 0.7281 (5.0); 0.7184 (1.3); 0.0713 (0.5); -0.0002 (4.4)
I-198:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1464 (2.8); 8.0247 (0.4); 7.4645 (0.5); 7.4376 (1.4); 7.4107 (1.1); 7.3760 (1.0); 7.3624 (0.8); 7.3588 (1.0); 7.3560 (1.0); 7.3522 (1.4); 7.3355 (0.4); 7.3318 (0.5); 7.3293 (0.5); 7.3259 (0.4); 7.3042 (8.5); 7.2586 (0.8); 7.2516 (1.4); 7.2448 (0.8); 7.1694 (0.7); 7.1660 (0.7); 7.1619 (0.6); 7.1586 (0.5); 7.1426 (0.6); 7.1391 (0.6); 7.1350 (0.5); 7.1316 (0.4); 7.0778 (1.2); 6.9963 (0.6); 6.9701 (0.6); 5.3433 (0.6); 4.3047 (0.6); 4.2850 (0.5); 4.2568 (1.2); 4.2371 (1.2); 4.2089 (0.6); 4.1892 (0.6); 2.7610 (8.6); 2.5167 (3.3); 2.5094 (1.8); 2.3368 (4.6); 2.0511 (0.6); 1.6083 (16.0); 1.3097 (1.4); 0.9469 (0.5); 0.9248 (1.5); 0.9018 (0.6); 0.0427 (7.3)
I-199:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5287 (0.5); 7.5089 (2.5); 7.4947 (5.9); 7.4039 (3.5); 7.3904 (1.5); 7.3826 (1.8); 7.3771 (1.4); 7.3678 (1.3); 7.2766 (4.5); 7.2594 (19.0); 7.1458 (4.9); 7.1261 (3.6); 6.3003 (1.3); 6.2802 (1.3); 5.3549 (0.4); 5.3371 (1.2); 5.3187 (1.7); 5.3003 (1.2); 4.3656 (0.3); 4.3482 (1.0); 4.3427 (0.8); 4.3306 (1.2); 4.3252 (2.1); 4.3075 (2.3); 4.2885 (2.3); 4.2709 (2.1); 4.2655 (1.1); 4.2534 (0.8); 4.2479 (0.9); 2.9454 (0.9); 2.8652 (0.8); 2.3509 (0.8); 2.3265 (16.0); 2.2823 (0.8); 1.6098 (9.3); 1.5925 (9.2); 1.5483 (19.0); 1.5244 (0.5); 1.4948 (0.4); 1.4071 (0.4); 1.3890 (0.4); 1.3755 (5.7); 1.3580 (11.4); 1.3406 (5.5); -0.0002 (4.6)
I-200:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1133 (5.2); 7.8800 (0.4); 7.8605 (0.7); 7.8416 (0.4); 7.6515 (0.6); 7.6436 (0.8); 7.6288 (1.1); 7.6259 (1.1); 7.6149 (1.4); 7.6050 (0.9); 7.5913 (1.0); 7.5847 (2.3); 7.5562 (2.4); 7.5111 (1.8); 7.5075 (1.8); 7.5047 (1.9); 7.4300 (0.8); 7.4021 (1.2); 7.3740 (0.5); 7.2985 (8.7); 7.2890 (1.3); 7.2674 (1.0); 7.2606 (1.0); 4.5113 (1.0); 4.4905 (1.0); 4.4641 (2.2); 4.4434 (2.1); 4.4170 (1.1); 4.3962 (1.0); 2.7572 (16.0); 1.6050 (1.3); 1.2272 (0.6); 0.0364 (8.4)
I-201:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9353 (6.0); 8.9235 (0.4); 7.9265 (0.5); 7.9078 (0.8); 7.8901 (0.5); 7.6931 (0.4); 7.6671 (1.5); 7.6452 (4.3); 7.6294 (0.5); 7.5775 (2.6); 7.5754 (2.5); 7.5485 (2.0); 7.4883 (0.9); 7.4799 (1.4); 7.4726 (1.0); 7.4689 (0.8); 7.4584 (1.1); 7.4508 (0.6); 7.3874 (7.0); 7.2987 (5.1); 6.1291 (0.6); 6.1183 (0.7); 6.1054 (0.6); 6.0945 (0.6); 5.9736 (0.6); 5.9627 (0.7); 5.9498 (0.7); 5.9390 (0.6); 5.8366 (3.2); 4.3107 (0.4); 4.2997 (0.4); 4.2883 (0.4); 4.2774 (0.4); 4.2687 (0.3); 4.2199 (0.4); 4.2088 (0.4); 4.1975 (0.4); 4.1867 (0.3); 3.8980 (0.3); 3.8809 (0.4); 3.8742 (0.4); 3.8570 (0.5); 3.8494 (0.4); 3.8321 (0.5); 3.8275 (0.6); 3.8104 (0.6); 3.7872 (0.4); 3.7793 (0.3); 2.3237 (16.0); 2.0413 (0.5); 1.6246 (0.9); 0.0363 (4.5)
I-202:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1748 (2.4); 9.1592 (5.2); 9.1439 (2.4); 7.9608 (1.5); 7.6801 (2.1); 7.6605 (5.8); 7.6409 (4.6); 7.6090 (6.2); 7.5896 (3.2); 7.5718 (0.4); 7.5529 (9.8); 7.5314 (13.2); 7.4184 (8.5); 7.4071 (16.0); 7.3860 (13.0); 5.8159 (7.7); 5.8019 (7.9); 4.6007 (3.0); 4.5834 (4.8); 4.5602 (4.2); 4.4935 (0.6); 4.4673 (2.6); 4.4533 (2.3); 4.4422 (1.3); 4.4251 (0.5); 4.1391 (5.8); 4.1299 (6.9); 4.1093 (7.9); 4.0944 (4.8); 4.0731 (2.4); 4.0575 (2.2); 3.3121 (159.6); 2.8990 (9.6); 2.7399 (8.7); 2.5135 (28.4); 2.5091 (39.0); 2.5048 (29.2)
I-203:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1068 (1.2); 9.0922 (2.5); 9.0779 (1.2); 8.0613 (11.4); 7.9607 (0.4); 7.7585 (5.5); 7.6685 (1.4); 7.6488 (3.4); 7.6291 (2.3); 7.5368 (3.0); 7.5168 (2.6); 7.4915 (16.0); 7.4710 (0.8); 7.4480 (2.4); 7.4278 (2.0); 7.2430 (2.0); 7.1037 (4.2); 6.9646 (2.1); 6.0499 (0.9); 6.0370 (1.8); 6.0248 (0.9); 5.9347 (0.9); 5.9218 (1.9); 5.9093 (0.9); 3.8975 (1.5); 3.8835 (2.5); 3.8703 (1.4); 3.8394 (1.6); 3.8256 (2.6); 3.8121 (1.4); 3.3114 (23.7); 2.8986 (2.5); 2.7397 (2.3); 2.5130 (10.6); 2.5087 (14.2); 2.5045 (10.7)
I-204:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5549 (0.7); 7.5286 (1.7); 7.4982 (3.0); 7.4691 (4.0); 7.4407 (1.5); 7.4149 (1.0); 7.3903 (3.8); 7.3623 (2.2); 7.3124 (1.9); 7.2983 (3.7); 7.2866 (1.1); 7.2834 (1.2); 7.2800 (0.9); 7.2600 (0.8); 7.2567 (0.9); 7.2527 (0.8); 7.0731 (0.5); 7.0523 (1.1); 7.0313 (0.5); 6.8659 (1.1); 6.6782 (2.3); 6.4906 (1.2); 4.1864 (0.9); 4.1654 (0.8); 4.1389 (1.9); 4.1179 (1.8); 4.0914 (0.9); 4.0704 (0.9); 2.2769 (16.0); 1.6432 (4.2); 1.2921 (0.8); 0.9177 (0.4); 0.0358 (3.5)
I-205:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0585 (1.3); 9.0381 (1.3); 7.7720 (6.1); 7.7301 (0.6); 7.7103 (1.7); 7.6910 (1.4); 7.6576 (3.6); 7.6358 (1.0); 7.5841 (1.4); 7.5646 (1.0); 7.1422 (2.5); 7.0959 (0.9); 7.0764 (1.7); 7.0728 (1.7); 7.0337 (2.6); 7.0141 (1.4); 5.0822 (0.8); 5.0637 (1.1); 5.0454 (0.8); 3.3628 (27.9); 3.3529 (39.6); 2.8905 (1.3); 2.7320 (1.1); 2.6016 (16.0); 2.5125 (7.2); 2.5081 (15.5); 2.5036 (21.0); 2.4990 (15.2); 2.4946 (7.4); 2.1451 (11.4); 2.0714 (11.9); 1.4126 (6.1); 1.3952 (6.1); -0.0002 (0.4)
I-206:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1362 (1.4); 9.1161 (1.5); 7.8091 (6.7); 7.7325 (0.6); 7.7126 (1.9); 7.6929 (4.0); 7.6557 (2.0); 7.6361 (1.1); 7.6026 (1.5); 7.5846 (1.0); 7.5813 (1.0); 7.1784 (2.4); 7.1733 (2.9); 7.1338 (2.8); 7.1287 (2.3); 5.1990 (0.9); 5.1806 (1.3); 5.1619 (0.9); 4.5703 (1.4); 4.5606 (1.0); 4.5480 (2.4); 4.5391 (2.4); 4.5262 (1.2); 4.5171 (1.4); 3.3328 (44.4); 3.1839 (1.6); 3.1620 (3.0); 3.1403 (1.5); 2.8923 (0.4); 2.7335 (0.3); 2.6100 (16.0); 2.5121 (13.6); 2.5081 (25.7); 2.5036 (33.0); 2.4990 (24.3); 2.4947 (12.4); 1.3867 (6.3); 1.3692 (6.3); 1.2405 (0.6)
I-207:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 20.0124 (0.4); 10.0224 (0.4); 9.3809 (1.0); 9.3655 (2.3); 9.3488 (1.0); 9.0570 (0.4); 8.3155 (10.9); 8.1369 (0.6); 7.7526 (1.1); 7.7323 (2.9); 7.7130 (2.5); 7.6917 (3.5); 7.6698 (1.5); 7.6192 (0.5); 7.5873 (4.1); 7.5643 (2.4); 7.5447 (2.0); 7.3534 (3.0); 7.3336 (3.4); 7.3038 (1.1); 7.2871 (0.7); 7.1044 (4.2); 7.0546 (0.9); 6.9787 (0.4); 6.9608 (1.9); 6.9424 (1.8); 6.8147 (0.5); 6.7975 (0.4); 5.8126 (0.5); 5.7938 (1.1); 5.7760 (0.6); 4.6906 (0.5); 4.6189 (0.6); 4.5999 (1.3); 4.5812 (0.7); 4.1825 (0.9); 4.1680 (0.9); 4.1454 (1.9); 4.1300 (1.9); 4.1059 (1.1); 4.0909 (1.1); 3.9846 (2.2); 3.9732 (2.3); 3.9557 (2.6); 3.9448 (2.4); 3.8761 (0.4); 3.7812 (0.6); 3.7535 (0.6); 3.7345 (0.6); 3.5993 (0.4); 3.5345 (0.6); 3.5147 (1.0); 3.5077 (0.9); 3.4802 (1.0); 3.4613 (0.8); 3.3370 (3221.7); 3.3038 (12.7); 3.2515 (4.9); 3.2335 (0.9); 3.1956 (1.4); 3.1672 (0.9); 2.7913 (0.4); 2.7825 (0.4); 2.6807 (9.8); 2.6763 (13.3); 2.6717 (9.8); 2.5466 (17.0); 2.5294 (50.5); 2.5160 (868.8); 2.5118 (1671.2); 2.5073 (2151.6); 2.5027 (1564.0); 2.4984 (767.0); 2.4315 (11.8); 2.3385 (9.7); 2.3340 (13.1); 2.3296 (9.5); 2.2824 (1.7); 2.2723 (1.1); 2.2470 (16.0); 2.2247 (2.4); 2.2069 (4.7); 2.2015 (3.3); 2.0772 (15.9); 1.5880 (2.2); 1.5613 (2.0); 1.3970 (0.5); 1.3308 (0.4); 1.2386 (0.5); 0.0044 (1.7)
I-208:1 H-NMR(400.0 MHz, CD3CN): δ= 8.0396 (16.0); 7.6707 (0.8); 7.6510 (3.7); 7.6349 (10.5); 7.6184 (0.8); 7.5355 (1.1); 7.5162 (5.0); 7.4333 (0.3); 7.4195 (1.7); 7.4131 (3.3); 7.4078 (2.2); 7.4021 (1.3); 7.3970 (2.1); 7.3913 (1.4); 6.9561 (3.0); 6.9371 (4.7); 6.8766 (3.8); 6.8566 (9.0); 5.4461 (3.2); 4.4261 (0.4); 4.4182 (0.5); 4.4136 (0.6); 4.4061 (1.4); 4.3987 (1.2); 4.3944 (1.3); 4.3858 (2.0); 4.3772 (1.3); 4.3730 (1.3); 4.3655 (1.4); 4.3579 (0.5); 4.3534 (0.5); 4.3456 (0.4); 3.0961 (1.5); 3.0842 (1.5); 3.0557 (2.0); 3.0436 (1.9); 2.8693 (3.6); 2.8526 (7.0); 2.8359 (3.7); 2.7972 (2.0); 2.7776 (1.9); 2.7568 (1.5); 2.7375 (1.5); 2.4618 (0.3); 2.1843 (26.2); 2.1478 (48.9); 2.1188 (0.4); 2.1126 (0.6); 2.1064 (1.1); 2.1002 (0.8); 2.0952 (0.7); 2.0905 (1.0); 2.0878 (1.1); 2.0827 (1.1); 2.0800 (1.1); 2.0739 (1.3); 2.0716 (1.3); 2.0663 (1.3); 2.0638 (1.3); 2.0581 (1.6); 2.0555 (1.6); 2.0503 (1.6); 2.0478 (1.5); 2.0422 (0.8); 2.0345 (0.7); 1.9677 (1.5); 1.9633 (3.2); 1.9572 (8.3); 1.9514 (42.0); 1.9453 (73.3); 1.9391 (96.6); 1.9329 (67.7); 1.9267 (34.6); 1.9136 (1.5); 1.8970 (1.3); 1.8785 (0.5); 1.7737 (0.4); 1.7675 (0.6); 1.7614 (0.4); 1.2849 (0.3); 1.2699 (0.7); 1.0834 (0.5); 0.8808 (0.5); 0.1461 (0.4); 0.0078 (4.2); -0.0003 (98.5); -0.0085 (3.8); -0.1496 (0.4)
I-209:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2518 (9.6); 8.0159 (0.4); 7.7993 (1.4); 7.4301 (1.2); 7.4260 (1.3); 7.4094 (2.4); 7.3947 (1.4); 7.3898 (1.4); 7.3364 (3.5); 7.3165 (3.8); 7.2594 (30.5); 7.2502 (3.2); 7.2460 (2.2); 7.2348 (2.3); 7.2297 (2.0); 7.2203 (2.7); 7.1994 (2.6); 7.1788 (1.0); 7.0305 (4.1); 6.9455 (2.2); 6.9253 (2.0); 4.2523 (1.8); 4.2373 (1.8); 4.2166 (3.7); 4.2018 (3.5); 4.1810 (1.9); 4.1660 (1.8); 2.9547 (3.0); 2.8824 (2.8); 2.4716 (11.5); 2.2759 (16.0); 2.1577 (0.4); 1.5436 (25.3); -0.0002 (1.5)
I-210:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.6587 (2.9); 7.7285 (0.6); 7.7088 (1.8); 7.6891 (1.6); 7.6634 (2.0); 7.6462 (6.6); 7.5367 (2.5); 7.5110 (1.4); 7.4913 (1.1); 7.1231 (3.5); 7.1034 (4.2); 6.8923 (3.8); 6.8730 (3.2); 3.3269 (19.8); 2.8901 (0.9); 2.8626 (6.3); 2.7310 (0.8); 2.5640 (16.0); 2.5061 (18.6); 2.5017 (24.6); 2.4974 (18.0); 2.1415 (12.4); 1.2402 (0.6); 0.8456 (1.0); 0.8278 (3.4); 0.8168 (1.5); 0.7324 (1.4); 0.7213 (3.3); 0.7039 (0.9); -0.0002 (3.4)
I-211:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1988 (1.6); 9.1836 (3.5); 9.1680 (1.8); 7.9613 (2.4); 7.6843 (1.5); 7.6647 (4.0); 7.6448 (3.2); 7.6119 (4.2); 7.5924 (2.3); 7.5658 (6.6); 7.5444 (9.2); 7.4433 (5.5); 7.4293 (9.7); 7.4079 (8.1); 7.1077 (0.9); 7.0950 (2.6); 7.0821 (2.7); 7.0704 (1.0); 4.1666 (1.4); 4.1513 (1.5); 4.1306 (3.1); 4.1152 (3.0); 4.0941 (1.7); 4.0787 (1.6); 3.3121 (107.0); 2.8991 (16.0); 2.8008 (14.2); 2.7879 (14.5); 2.7402 (14.4); 2.5136 (18.7); 2.5092 (25.8); 2.5048 (19.5)
I-212:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1084 (1.7); 9.0940 (3.4); 9.0793 (1.7); 8.0638 (16.0); 7.9607 (2.4); 7.6669 (2.0); 7.6464 (9.8); 7.6275 (3.3); 7.5716 (5.5); 7.5506 (7.0); 7.5358 (4.2); 7.5166 (3.0); 7.4845 (5.7); 7.4479 (3.3); 7.4277 (2.8); 7.3831 (4.1); 7.3781 (4.0); 7.3622 (3.3); 7.3572 (3.3); 7.2414 (2.8); 7.1021 (5.9); 6.9629 (2.9); 6.0650 (1.2); 6.0522 (2.4); 6.0398 (1.2); 5.9494 (1.2); 5.9370 (2.5); 5.9244 (1.2); 3.9017 (2.2); 3.8879 (3.7); 3.8743 (2.1); 3.8438 (2.3); 3.8298 (3.8); 3.8163 (2.1); 3.3117 (32.2); 2.8985 (14.8); 2.7396 (13.4); 2.5130 (13.5); 2.5087 (18.0); 2.5045 (13.5)
I-213:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1937 (1.2); 9.1739 (1.2); 7.8043 (6.3); 7.7302 (0.6); 7.7104 (1.7); 7.6908 (1.4); 7.6631 (2.4); 7.6584 (2.8); 7.6346 (1.0); 7.5874 (1.4); 7.5682 (1.0); 7.4711 (2.7); 7.3716 (0.9); 7.3682 (0.6); 7.3562 (1.3); 7.3527 (2.2); 7.3377 (1.6); 7.3186 (3.0); 7.2999 (1.5); 7.2857 (1.4); 7.2813 (2.2); 7.2768 (1.3); 7.2665 (0.7); 7.2620 (1.0); 7.2577 (0.6); 5.1618 (0.8); 5.1434 (1.2); 5.1250 (0.8); 3.3663 (18.7); 3.3568 (28.2); 2.8914 (1.2); 2.7330 (1.0); 2.6102 (16.0); 2.5141 (5.5); 2.5097 (11.5); 2.5051 (15.4); 2.5006 (11.0); 2.4962 (5.3); 1.4448 (6.3); 1.4272 (6.3); -0.0002 (0.3)
I-214:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0162 (0.7); 9.0069 (0.8); 8.9961 (0.8); 8.9867 (0.8); 7.9526 (0.6); 7.7674 (6.6); 7.7264 (0.6); 7.7077 (1.5); 7.6864 (1.2); 7.6475 (4.3); 7.6286 (1.0); 7.5706 (1.4); 7.5528 (0.9); 7.2086 (2.3); 7.0893 (1.1); 7.0688 (1.2); 6.6117 (1.6); 6.6085 (1.7); 6.5913 (1.5); 6.5881 (1.6); 5.0780 (0.5); 5.0721 (0.5); 5.0558 (0.7); 5.0405 (0.5); 5.0349 (0.5); 4.8611 (0.4); 4.8448 (0.7); 4.8420 (0.8); 4.8263 (0.8); 4.8235 (0.7); 4.8072 (0.5); 3.3319 (26.9); 3.1977 (0.4); 3.1760 (0.4); 3.1575 (0.8); 3.1351 (0.7); 3.1164 (0.5); 3.0946 (0.4); 2.8918 (4.8); 2.7334 (4.0); 2.6671 (0.6); 2.6478 (0.5); 2.6275 (0.4); 2.6008 (16.0); 2.5825 (0.6); 2.5635 (0.5); 2.5430 (0.5); 2.5254 (0.8); 2.5210 (0.9); 2.5121 (10.2); 2.5076 (20.9); 2.5030 (27.4); 2.4984 (19.5); 2.4939 (9.3); 1.4096 (3.9); 1.4069 (4.0); 1.3923 (3.9); 1.3895 (3.9); 1.3322 (4.2); 1.3166 (4.7); 1.3127 (4.8); 1.2970 (4.3); 1.2408 (0.5)
I-215:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3531 (2.4); 7.3460 (2.5); 7.2986 (8.2); 7.2264 (2.0); 7.1991 (2.5); 7.1525 (0.5); 7.1260 (1.4); 7.0992 (2.9); 7.0908 (1.4); 7.0758 (1.0); 7.0699 (1.2); 7.0490 (0.5); 7.0428 (0.4); 7.0020 (1.6); 6.9949 (1.5); 6.9746 (1.2); 6.9676 (1.2); 6.8696 (0.6); 6.8616 (0.6); 6.8466 (1.2); 6.8399 (1.0); 6.8216 (0.6); 6.8157 (0.5); 6.2262 (0.4); 6.2082 (0.7); 6.1896 (0.4); 5.3369 (1.1); 3.8782 (1.0); 3.8569 (2.5); 3.8352 (2.5); 3.8137 (1.1); 3.1285 (1.8); 3.1064 (3.2); 3.0845 (1.6); 2.4593 (16.0); 2.3015 (0.3); 2.1128 (0.4); 2.1013 (0.5); 2.0845 (0.9); 2.0674 (0.5); 2.0561 (0.5); 1.5942 (6.3); 1.0801 (0.6); 1.0647 (1.7); 1.0580 (1.9); 1.0432 (1.1); 1.0361 (1.9); 1.0296 (1.7); 1.0150 (0.9); 0.8220 (0.8); 0.8069 (2.1); 0.8010 (2.0); 0.7900 (1.9); 0.7844 (2.2); 0.7680 (0.7); 0.1076 (0.6); 0.0377 (7.1); 0.0268 (0.4)
I-216:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4207 (8.4); 8.1695 (8.3); 7.6569 (0.3); 7.6306 (2.5); 7.6247 (2.2); 7.6200 (2.2); 7.6127 (6.3); 7.6093 (6.6); 7.5940 (0.5); 7.5196 (2.9); 7.5018 (0.5); 7.4948 (0.3); 7.4871 (1.3); 7.4751 (1.8); 7.4684 (1.5); 7.4569 (1.2); 7.4488 (0.7); 7.3284 (2.9); 7.2986 (23.0); 7.0485 (3.2); 6.9494 (1.8); 6.9235 (1.5); 6.6805 (0.8); 6.6604 (1.6); 6.6398 (0.8); 4.4252 (2.2); 4.4014 (7.2); 4.3777 (7.3); 4.3539 (2.3); 4.1493 (1.5); 4.1287 (1.5); 4.1009 (3.2); 4.0803 (3.1); 4.0524 (1.6); 4.0318 (1.6); 2.4588 (9.6); 2.4517 (5.4); 2.2979 (12.8); 1.6027 (14.4); 1.4393 (7.5); 1.4156 (16.0); 1.3918 (7.3); 1.2944 (0.5); 0.1083 (2.0); 0.0492 (0.8); 0.0383 (23.7); 0.0273 (0.8)
I-217:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2469 (0.7); 9.2319 (1.5); 9.2168 (0.7); 8.3167 (3.7); 7.7176 (0.8); 7.6981 (2.0); 7.6788 (1.5); 7.6445 (1.9); 7.6252 (1.0); 7.5400 (2.5); 7.5093 (1.4); 7.4894 (1.1); 7.3263 (2.3); 7.3061 (2.6); 7.0976 (2.7); 6.9748 (1.4); 6.9545 (1.2); 5.7954 (0.5); 4.6189 (0.3); 4.6002 (0.6); 4.1447 (0.8); 4.1304 (0.7); 4.1080 (1.6); 4.0921 (1.5); 4.0700 (0.8); 4.0545 (0.8); 3.8685 (0.3); 3.4049 (0.7); 3.3351 (765.0); 3.2773 (0.9); 3.2655 (0.7); 2.9207 (1.2); 2.9020 (3.9); 2.8832 (4.0); 2.8647 (1.3); 2.6809 (3.2); 2.6764 (4.3); 2.6718 (3.1); 2.6674 (1.5); 2.5466 (2.3); 2.5298 (14.1); 2.5250 (22.0); 2.5164 (265.4); 2.5120 (532.8); 2.5074 (697.8); 2.5028 (506.6); 2.4984 (246.3); 2.4362 (7.7); 2.4090 (0.4); 2.3433 (1.4); 2.3388 (3.1); 2.3342 (4.3); 2.3296 (3.0); 2.2495 (10.2); 2.1460 (16.0); 2.0778 (4.0); 1.2576 (4.8); 1.2390 (10.7); 1.2204 (4.7); 0.0045 (0.9)
I-218:1 H-NMR(499.9 MHz, CDCl3): δ= 8.0987 (5.1); 7.9717 (0.9); 7.4054 (1.1); 7.3892 (2.7); 7.3729 (1.8); 7.3259 (2.1); 7.3099 (3.6); 7.2939 (1.1); 7.2922 (1.2); 7.2906 (1.2); 7.2597 (13.7); 7.2113 (1.6); 7.2073 (2.7); 7.2032 (1.6); 7.1172 (1.3); 7.1156 (1.3); 7.1128 (1.3); 7.1009 (1.2); 7.0993 (1.2); 7.0965 (1.2); 7.0324 (2.5); 6.9465 (1.3); 6.9307 (1.3); 5.2977 (0.9); 4.2380 (1.0); 4.2262 (1.0); 4.2092 (2.2); 4.1974 (2.2); 4.1805 (1.1); 4.1687 (1.1); 2.7164 (16.0); 2.4721 (7.0); 2.2922 (10.0); 2.0035 (1.1); 1.5548 (25.3); 1.3027 (0.6); 1.2890 (0.8); 1.2657 (2.3); 1.2549 (1.7); 0.8957 (1.4); 0.8821 (3.2); 0.8679 (1.6); 0.0060 (0.5); -0.0002 (11.6)
I-219:1 H-NMR(400.1 MHz, CDCl3): δ= 8.1051 (5.3); 8.0178 (0.4); 7.8329 (0.8); 7.5984 (0.7); 7.5791 (1.6); 7.5590 (1.5); 7.5401 (0.9); 7.3709 (0.9); 7.3465 (2.7); 7.3261 (2.5); 7.2597 (26.0); 7.0239 (2.3); 6.9423 (1.2); 6.9217 (1.1); 4.2635 (1.0); 4.2486 (1.0); 4.2278 (2.2); 4.2129 (2.1); 4.1920 (1.1); 4.1771 (1.0); 2.9552 (2.8); 2.8829 (2.6); 2.7209 (16.0); 2.4775 (6.5); 2.2935 (0.4); 2.2578 (9.0); 1.5471 (15.3); -0.0002 (1.4)
I-220:1 H-NMR(300.2 MHz, CDCl3): δ= 8.6328 (11.8); 7.9198 (0.8); 7.9038 (1.4); 7.8858 (0.8); 7.7332 (6.6); 7.7161 (5.2); 7.6876 (0.4); 7.5464 (3.4); 7.5231 (0.3); 7.5107 (1.5); 7.5022 (1.5); 7.4920 (2.0); 7.4856 (1.6); 7.4804 (1.2); 7.4721 (0.9); 7.3793 (3.5); 7.3527 (4.0); 7.3040 (14.5); 7.0919 (3.9); 7.0049 (2.2); 6.9782 (1.9); 5.3433 (0.4); 4.3273 (1.9); 4.3075 (1.8); 4.2791 (4.0); 4.2593 (3.9); 4.2308 (2.0); 4.2111 (2.0); 2.5174 (11.7); 2.5102 (6.4); 2.3309 (16.0); 2.0884 (0.3); 1.5993 (13.9); 1.3327 (0.4); 1.3025 (0.4); 1.2884 (0.4); 0.1138 (0.4); 0.0539 (0.5); 0.0431 (13.4); 0.0322 (0.4)
I-221:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9850 (0.6); 7.5515 (0.5); 7.5318 (2.3); 7.5166 (5.5); 7.4147 (2.8); 7.3663 (1.1); 7.3594 (1.7); 7.3538 (1.3); 7.3435 (1.2); 7.3379 (0.7); 7.2595 (13.1); 7.0273 (2.3); 7.0082 (3.0); 6.9624 (3.2); 6.8731 (1.8); 6.8545 (1.4); 6.1053 (0.7); 6.0918 (1.2); 6.0785 (0.7); 4.3658 (1.7); 4.3483 (5.4); 4.3308 (5.4); 4.3134 (1.7); 3.7641 (1.4); 3.7472 (3.6); 3.7317 (3.6); 3.7150 (1.5); 2.9474 (4.4); 2.9334 (2.5); 2.9163 (4.6); 2.8992 (2.2); 2.8684 (3.9); 2.3341 (0.7); 2.2880 (16.0); 2.2549 (14.6); 2.1909 (0.6); 1.5508 (13.8); 1.4420 (5.6); 1.4245 (11.1); 1.4070 (5.6); 1.3891 (0.5); -0.0002 (3.8)
I-222:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5662 (8.2); 8.0482 (0.6); 8.0301 (1.1); 8.0117 (0.6); 7.6932 (0.3); 7.6668 (2.1); 7.6583 (1.8); 7.6478 (5.7); 7.6446 (4.8); 7.6326 (0.4); 7.5269 (2.7); 7.5012 (1.1); 7.4900 (1.5); 7.4829 (1.3); 7.4706 (1.1); 7.4629 (0.6); 7.3886 (2.5); 7.3621 (2.9); 7.3040 (11.0); 7.0814 (2.8); 6.9939 (1.6); 6.9667 (1.4); 5.9433 (4.3); 5.5523 (2.9); 5.5494 (2.9); 4.3318 (1.4); 4.3120 (1.3); 4.2836 (2.9); 4.2638 (2.8); 4.2355 (1.4); 4.2158 (1.4); 2.5292 (8.5); 2.5220 (4.7); 2.3340 (12.4); 2.3218 (12.3); 1.6060 (16.0); 0.0535 (0.4); 0.0427 (10.1); 0.0319 (0.4)
I-223:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1613 (5.1); 7.9345 (0.6); 7.9155 (0.4); 7.6444 (0.6); 7.6209 (1.0); 7.6154 (1.1); 7.5859 (1.2); 7.5627 (0.7); 7.4189 (0.8); 7.3929 (1.3); 7.3652 (22.9); 7.2989 (15.1); 5.8332 (0.5); 5.8219 (0.6); 5.8077 (0.6); 5.7964 (0.6); 5.6743 (0.6); 5.6631 (0.6); 5.6489 (0.6); 5.6376 (0.6); 4.2184 (0.4); 4.2072 (0.4); 4.1959 (0.3); 4.1845 (0.4); 4.1264 (0.4); 4.1150 (0.4); 4.1039 (0.4); 4.0926 (0.4); 3.8866 (0.3); 3.8700 (0.4); 3.8613 (0.4); 3.8444 (0.4); 3.8224 (0.6); 3.8125 (0.4); 3.8060 (0.4); 3.7967 (0.5); 3.7804 (0.4); 3.2529 (0.3); 2.8413 (1.2); 2.7754 (16.0); 1.5936 (9.7); 1.2283 (1.1); 0.0482 (0.6); 0.0374 (15.0); 0.0266 (0.5)
I-224:1 H-NMR(600.4 MHz, d6 -DMSO): δ= 8.0623 (2.4); 7.7214 (0.5); 7.7081 (1.3); 7.7034 (4.4); 7.6950 (0.9); 7.6520 (1.0); 7.6390 (0.7); 7.5731 (1.4); 7.5445 (0.8); 7.5311 (0.7); 7.5278 (0.7); 7.5075 (0.4); 7.4932 (0.6); 7.4380 (0.7); 7.4239 (0.4); 7.2309 (2.1); 7.2279 (0.8); 7.2200 (1.0); 7.2169 (3.4); 7.2130 (0.5); 7.1733 (0.5); 7.1693 (3.8); 7.1660 (1.0); 7.1584 (0.8); 7.1553 (2.4); 5.7520 (0.4); 5.3952 (1.0); 3.3051 (90.1); 3.0744 (4.4); 2.6449 (2.1); 2.6150 (0.6); 2.6120 (0.9); 2.6089 (0.7); 2.5998 (11.4); 2.5210 (2.1); 2.5180 (2.5); 2.5148 (2.6); 2.5061 (49.0); 2.5031 (102.1); 2.5000 (137.6); 2.4970 (100.3); 2.4940 (47.4); 2.3870 (0.6); 2.3840 (0.8); 2.3809 (0.6); 1.2951 (16.0); -0.0002 (0.9)
I-225:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2467 (1.2); 9.2313 (2.6); 9.2156 (1.2); 7.9610 (2.4); 7.6902 (1.0); 7.6705 (2.9); 7.6508 (2.3); 7.6194 (3.0); 7.6000 (1.6); 7.5598 (4.9); 7.5384 (6.5); 7.4489 (3.9); 7.4288 (2.3); 7.4103 (8.0); 7.3893 (5.0); 6.4397 (1.2); 6.4261 (2.5); 6.4123 (1.2); 4.9757 (1.9); 4.9625 (4.3); 4.9493 (2.0); 4.1602 (1.0); 4.1442 (1.0); 4.1237 (2.2); 4.1083 (2.1); 4.0872 (1.2); 4.0719 (1.1); 3.5857 (1.5); 3.5719 (4.4); 3.5583 (4.6); 3.5447 (1.8); 3.3123 (86.8); 3.2727 (1.8); 3.2590 (4.4); 3.2450 (4.2); 3.2310 (1.4); 2.8989 (16.0); 2.7398 (14.3); 2.5133 (14.5); 2.5090 (19.8); 2.5046 (14.5)
I-226:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0798 (1.9); 9.0643 (4.0); 9.0488 (2.0); 7.9607 (0.4); 7.6861 (16.0); 7.6427 (2.3); 7.6229 (5.5); 7.6022 (10.9); 7.5807 (12.1); 7.5060 (15.6); 7.4847 (11.3); 7.4233 (6.5); 7.3787 (3.8); 7.3584 (3.1); 7.2332 (3.2); 7.0938 (6.8); 6.9545 (3.4); 4.1323 (2.0); 4.1166 (2.2); 4.0972 (4.5); 4.0816 (4.4); 4.0622 (2.4); 4.0465 (2.2); 3.3141 (87.3); 2.8984 (2.4); 2.7397 (2.2); 2.5966 (40.8); 2.5130 (16.2); 2.5088 (21.5); 2.5045 (16.0)
I-227:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2166 (1.2); 9.1971 (1.3); 7.9550 (0.6); 7.8076 (6.4); 7.7326 (0.6); 7.7130 (1.5); 7.6921 (1.3); 7.6547 (7.1); 7.6499 (4.4); 7.6385 (1.1); 7.5824 (1.4); 7.5620 (3.9); 7.5412 (3.9); 7.4065 (1.7); 7.4015 (1.7); 7.3855 (1.3); 7.3804 (1.3); 5.1534 (0.8); 5.1353 (1.2); 5.1171 (0.8); 3.3835 (25.7); 3.3787 (39.2); 3.3743 (46.6); 2.8936 (4.0); 2.7348 (3.5); 2.6115 (16.0); 2.5171 (5.4); 2.5126 (11.6); 2.5081 (15.7); 2.5035 (11.4); 2.4990 (5.5); 1.4416 (6.1); 1.4241 (6.0)
I-228:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4710 (16.0); 8.4403 (6.2); 8.1265 (1.0); 8.1086 (1.7); 8.0879 (1.1); 7.7601 (5.6); 7.7205 (3.5); 7.7012 (9.4); 7.6979 (8.6); 7.6854 (1.4); 7.6446 (0.3); 7.6042 (5.7); 7.6003 (4.0); 7.5776 (4.2); 7.5369 (0.6); 7.5304 (0.5); 7.5208 (1.8); 7.5105 (2.8); 7.5033 (2.4); 7.4901 (2.4); 7.4820 (1.9); 7.4754 (0.8); 7.4449 (1.2); 7.4395 (1.0); 7.4170 (6.3); 7.4115 (6.8); 7.4045 (9.0); 7.3769 (1.7); 7.3064 (6.2); 7.2988 (34.3); 7.2250 (0.4); 7.2185 (0.3); 7.1644 (0.5); 6.1562 (1.1); 6.1458 (1.3); 6.1323 (1.3); 6.1219 (1.2); 6.0008 (1.1); 5.9904 (1.2); 5.9770 (1.3); 5.9665 (1.2); 4.4019 (0.6); 4.3914 (0.6); 4.3793 (0.6); 4.3688 (0.6); 4.3531 (0.7); 4.3427 (0.8); 4.3305 (0.7); 4.3201 (0.8); 4.3110 (0.7); 4.3006 (0.6); 4.2885 (0.7); 4.2780 (0.6); 4.2622 (0.8); 4.2514 (0.7); 4.2397 (0.8); 4.2291 (0.7); 4.1690 (0.9); 4.1452 (0.9); 4.1216 (0.3); 3.9374 (0.7); 3.9202 (0.8); 3.9133 (0.8); 3.9057 (0.5); 3.8962 (0.9); 3.8882 (0.9); 3.8668 (1.2); 3.8494 (1.2); 3.8435 (0.9); 3.8261 (0.8); 3.8184 (0.8); 3.8015 (0.6); 3.7945 (0.7); 3.7775 (0.6); 3.1384 (0.6); 2.0818 (4.4); 1.7188 (3.6); 1.4488 (0.8); 1.3192 (1.2); 1.2954 (2.6); 1.2716 (1.2); 1.1420 (2.4); 1.0728 (0.4); 1.0489 (0.5); 1.0251 (0.5); 0.1058 (7.2); 0.0462 (0.9); 0.0354 (32.5); 0.0245 (1.4)
I-229:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0213 (1.4); 9.0010 (1.4); 7.9521 (0.7); 7.7693 (6.5); 7.7265 (0.6); 7.7065 (1.7); 7.6875 (1.4); 7.6483 (4.3); 7.6284 (1.1); 7.5717 (1.4); 7.5526 (1.0); 7.2486 (2.6); 7.1010 (1.3); 7.0976 (1.2); 7.0806 (1.4); 7.0770 (1.4); 6.6504 (2.9); 6.6299 (2.7); 5.0833 (0.9); 5.0647 (1.2); 5.0464 (0.9); 4.4758 (2.2); 4.4543 (4.2); 4.4322 (2.5); 3.3304 (27.6); 3.0683 (0.4); 3.0509 (0.8); 3.0298 (1.4); 3.0204 (0.8); 3.0081 (0.7); 2.9983 (1.4); 2.9769 (0.8); 2.9594 (0.4); 2.8911 (5.0); 2.7325 (4.5); 2.6010 (16.0); 2.5247 (0.5); 2.5112 (10.1); 2.5070 (20.6); 2.5025 (27.3); 2.4980 (20.0); 2.4936 (10.0); 1.4115 (6.2); 1.3941 (6.2); 1.2404 (0.5)
I-230:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9168 (5.5); 7.9080 (5.5); 7.6276 (0.6); 7.6013 (3.3); 7.5938 (2.9); 7.5827 (8.1); 7.5793 (7.5); 7.5685 (0.8); 7.5635 (0.7); 7.4799 (3.7); 7.4630 (0.6); 7.4482 (1.7); 7.4365 (2.3); 7.4297 (2.0); 7.4175 (1.6); 7.4095 (0.9); 7.3414 (3.6); 7.3148 (4.2); 7.2983 (24.6); 7.0391 (4.1); 6.9219 (2.2); 6.8954 (1.9); 6.6557 (1.0); 6.6365 (1.9); 6.6171 (1.0); 6.3145 (6.2); 6.3056 (6.0); 4.1691 (1.9); 4.1486 (1.9); 4.1207 (4.1); 4.1002 (3.9); 4.0723 (2.1); 4.0519 (2.0); 2.4787 (12.0); 2.4718 (6.7); 2.4503 (0.6); 2.3451 (0.4); 2.2732 (16.0); 2.0655 (0.6); 2.0490 (1.1); 2.0375 (1.3); 2.0211 (2.3); 2.0046 (1.3); 1.9932 (1.3); 1.9767 (0.6); 1.6070 (8.7); 1.2944 (1.1); 1.0778 (1.5); 1.0631 (3.6); 1.0549 (4.2); 1.0412 (2.5); 1.0347 (3.8); 1.0266 (3.6); 1.0134 (1.9); 0.9915 (0.4); 0.9639 (0.3); 0.9246 (0.4); 0.9076 (0.4); 0.8750 (2.1); 0.8613 (4.6); 0.8538 (4.2); 0.8452 (4.2); 0.8381 (4.6); 0.8220 (1.4); 0.1084 (2.4); 0.0493 (1.2); 0.0385 (26.0); 0.0276 (1.1)
I-231:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 8.7846 (1.1); 8.7735 (1.9); 8.7623 (0.9); 8.0888 (5.9); 7.7555 (1.0); 7.7392 (2.4); 7.7234 (2.1); 7.6995 (3.1); 7.6856 (4.8); 7.6123 (2.0); 7.5959 (1.5); 7.0474 (2.7); 7.0321 (2.9); 6.9118 (3.7); 6.7791 (2.1); 6.7639 (1.8); 3.5016 (1.6); 3.4883 (3.1); 3.4750 (3.0); 3.4612 (1.2); 3.3319 (3.8); 2.8178 (2.6); 2.8033 (4.2); 2.7888 (2.1); 2.5046 (1.1); 2.2585 (16.0); 2.2399 (0.5); 2.2219 (0.4); 2.2159 (0.4); 2.1646 (14.6); -0.0002 (0.4)
I-232:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2795 (12.7); 8.1473 (1.4); 8.1280 (0.8); 7.3788 (3.5); 7.3523 (4.0); 7.3015 (25.6); 7.2705 (5.2); 7.2437 (2.9); 7.0803 (3.8); 7.0117 (2.2); 6.9856 (1.8); 6.6921 (2.0); 6.6896 (2.2); 6.6851 (2.3); 6.6826 (2.2); 6.6653 (1.8); 6.6626 (1.9); 6.6583 (2.2); 6.6556 (2.0); 6.6170 (1.9); 6.6145 (1.9); 6.6095 (2.6); 6.5904 (1.4); 6.5876 (1.5); 6.5829 (2.8); 6.5804 (2.4); 6.5698 (3.7); 6.5628 (5.2); 6.5555 (2.2); 5.3413 (3.9); 4.2815 (2.0); 4.2615 (1.9); 4.2332 (4.2); 4.2132 (4.0); 4.1986 (0.4); 4.1848 (2.1); 4.1744 (0.7); 4.1649 (2.1); 4.1506 (0.5); 3.8640 (5.5); 2.5202 (6.4); 2.5135 (11.7); 2.5061 (6.4); 2.3439 (16.0); 2.2704 (0.5); 2.0875 (2.1); 1.5984 (12.0); 1.3478 (0.5); 1.3244 (1.2); 1.3007 (3.1); 1.2769 (0.8); 0.9440 (0.8); 0.9224 (2.4); 0.8992 (0.9); 0.1104 (1.3); 0.0512 (0.9); 0.0404 (26.0); 0.0295 (0.9)
I-233:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.0602 (1.1); 9.0487 (2.1); 9.0370 (1.2); 7.8022 (6.2); 7.7844 (1.2); 7.7691 (2.1); 7.7535 (2.2); 7.7311 (4.6); 7.5479 (1.3); 7.5321 (3.2); 7.5159 (4.1); 7.5133 (4.1); 7.5002 (4.8); 7.4835 (1.8); 6.0570 (0.7); 6.0484 (1.0); 6.0457 (1.0); 6.0370 (0.8); 5.9646 (0.7); 5.9561 (1.0); 5.9532 (1.0); 5.9446 (0.8); 3.9395 (0.4); 3.9235 (0.6); 3.9105 (1.0); 3.8966 (0.8); 3.8796 (1.0); 3.8716 (1.1); 3.8666 (1.3); 3.8542 (0.9); 3.8440 (0.6); 3.8357 (0.8); 3.8258 (0.9); 3.8170 (0.6); 3.8076 (0.4); 3.7975 (0.4); 3.3441 (3.6); 2.6060 (16.0); 2.5683 (0.4); 2.5057 (0.8)
I-234:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2779 (0.8); 9.2627 (1.8); 9.2473 (0.9); 7.9612 (2.4); 7.6866 (0.8); 7.6669 (2.1); 7.6472 (1.7); 7.6128 (2.2); 7.5931 (1.2); 7.4750 (2.9); 7.4560 (1.8); 7.4359 (1.4); 7.2934 (2.4); 7.2734 (2.7); 7.0648 (3.0); 6.8913 (1.6); 6.8714 (1.5); 6.4239 (0.9); 6.4103 (1.8); 6.3967 (1.0); 4.9665 (1.3); 4.9533 (3.1); 4.9402 (1.4); 4.1108 (0.7); 4.0956 (0.8); 4.0729 (1.6); 4.0575 (1.6); 4.0347 (0.9); 4.0193 (0.8); 3.5863 (1.0); 3.5726 (3.1); 3.5591 (3.4); 3.5456 (1.4); 3.3121 (63.4); 3.2970 (2.4); 3.2828 (3.8); 3.2689 (3.4); 3.2552 (1.4); 2.8991 (16.0); 2.7402 (14.1); 2.5135 (11.0); 2.5091 (15.1); 2.5047 (11.4); 2.4005 (7.8); 2.2240 (10.8)
I-235:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0150 (3.2); 8.7090 (6.5); 8.7037 (6.6); 7.9720 (3.7); 7.9660 (3.7); 7.9509 (4.4); 7.9449 (4.4); 7.7240 (16.0); 7.7164 (8.1); 7.6950 (6.3); 7.6284 (2.2); 7.6088 (5.3); 7.5890 (3.5); 7.4936 (4.5); 7.4744 (3.4); 7.3944 (6.4); 7.3560 (3.6); 7.3359 (3.1); 7.2243 (3.1); 7.0849 (6.7); 6.9456 (3.3); 4.2523 (1.8); 4.2195 (3.6); 4.1841 (1.9); 3.3121 (26.6); 2.8986 (0.4); 2.7395 (0.4); 2.5962 (39.8); 2.5130 (13.2); 2.5087 (17.5); 2.5045 (13.1)
I-236:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2383 (1.5); 9.2182 (1.5); 7.9532 (0.5); 7.8164 (7.9); 7.7483 (2.1); 7.7356 (0.9); 7.7269 (2.6); 7.7161 (2.0); 7.6954 (4.0); 7.6698 (2.1); 7.6503 (1.0); 7.6261 (2.8); 7.6007 (1.5); 7.5713 (2.1); 7.5501 (2.2); 7.5248 (1.6); 7.5209 (1.8); 7.5036 (1.4); 7.4995 (1.5); 7.2886 (1.6); 7.2852 (1.7); 7.2677 (1.4); 7.2641 (1.5); 5.3080 (0.8); 5.2897 (1.2); 5.2712 (0.8); 3.3698 (36.6); 3.3631 (56.7); 3.3598 (62.3); 2.8901 (2.9); 2.7320 (2.6); 2.6126 (16.0); 2.5268 (0.4); 2.5132 (9.2); 2.5089 (19.5); 2.5044 (26.4); 2.4999 (19.4); 2.4955 (9.6); 2.4401 (11.2); 2.3700 (0.3); 1.5339 (6.0); 1.5165 (5.9); 1.2382 (0.3); -0.0002 (0.4)
I-237:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3491 (9.8); 8.0537 (9.4); 7.6696 (0.4); 7.6406 (3.7); 7.6346 (3.0); 7.6259 (7.2); 7.6229 (7.6); 7.6088 (0.6); 7.5308 (3.7); 7.5101 (0.5); 7.4968 (1.6); 7.4831 (2.1); 7.4765 (2.0); 7.4664 (1.6); 7.4584 (1.0); 7.3238 (3.5); 7.2981 (19.6); 7.0734 (4.1); 6.9790 (2.2); 6.9529 (1.9); 6.6691 (1.0); 6.6486 (1.9); 6.6285 (1.0); 4.1443 (1.9); 4.1235 (1.9); 4.1170 (2.4); 4.0953 (3.9); 4.0746 (3.7); 4.0463 (2.0); 4.0255 (1.9); 2.5184 (0.7); 2.4618 (12.0); 2.4548 (6.6); 2.3965 (0.3); 2.3248 (16.0); 2.0405 (1.9); 1.6050 (9.0); 1.2945 (0.7); 0.1086 (1.6); 0.0488 (0.8); 0.0382 (16.8); 0.0272 (0.5)
I-238:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5570 (1.8); 7.5516 (1.4); 7.5425 (3.0); 7.5396 (3.3); 7.4550 (1.6); 7.4110 (0.7); 7.4021 (0.7); 7.3972 (1.0); 7.3881 (2.0); 7.3724 (0.5); 7.3613 (1.8); 7.2986 (3.6); 7.0724 (1.8); 6.9900 (1.0); 6.9633 (0.8); 6.5969 (0.4); 6.5777 (0.8); 6.5576 (0.4); 4.2838 (0.8); 4.2634 (0.8); 4.2347 (1.7); 4.2142 (1.6); 4.1855 (0.9); 4.1650 (0.8); 2.5778 (16.0); 2.5043 (5.2); 2.3137 (7.0); 1.6055 (0.6); 1.2948 (0.5); 0.0388 (4.0)
I-239:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0252 (2.4); 9.0110 (4.1); 8.9982 (2.7); 8.9680 (0.4); 8.3158 (0.5); 8.0864 (16.0); 8.0805 (7.2); 7.7596 (1.7); 7.7419 (4.6); 7.7221 (5.0); 7.7027 (6.8); 7.6814 (9.3); 7.5988 (4.3); 7.5810 (3.6); 7.4555 (6.5); 7.4358 (11.0); 7.3784 (11.2); 7.3735 (8.9); 7.3577 (7.7); 7.2511 (0.5); 7.1957 (0.3); 5.8053 (1.4); 5.7880 (2.2); 5.7793 (1.8); 5.7555 (1.4); 5.6703 (2.2); 3.8729 (0.7); 3.8531 (1.6); 3.8366 (2.5); 3.8230 (3.0); 3.8030 (2.9); 3.7977 (2.7); 3.7870 (2.6); 3.7713 (1.9); 3.7624 (2.1); 3.7474 (1.9); 3.7177 (0.8); 3.3210 (174.5); 3.3165 (103.2); 2.8312 (0.4); 2.6704 (2.0); 2.5056 (268.7); 2.5012 (366.7); 2.4967 (331.7); 2.4058 (0.5); 2.3284 (2.1); 1.2504 (0.4); 1.2284 (0.6); 0.1461 (0.9); 0.0075 (24.0); -0.0004 (231.4); -0.0061 (97.0); -0.0696 (0.4); -0.0772 (0.3); -0.1495 (1.0); -0.1552 (0.6)
I-240:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3174 (14.7); 7.9784 (1.1); 7.9600 (1.8); 7.9422 (1.1); 7.6761 (6.4); 7.6586 (8.7); 7.6341 (0.3); 7.5361 (4.3); 7.4908 (0.5); 7.4782 (1.8); 7.4701 (1.9); 7.4626 (2.5); 7.4561 (2.2); 7.4477 (1.6); 7.4396 (1.2); 7.3622 (4.6); 7.3351 (5.1); 7.2982 (22.5); 6.9473 (5.2); 6.8639 (2.8); 6.8374 (2.5); 5.3376 (2.3); 4.2966 (2.3); 4.2769 (2.3); 4.2483 (4.9); 4.2285 (4.7); 4.1999 (2.5); 4.1802 (2.4); 2.5065 (14.8); 2.4994 (8.3); 1.9042 (0.6); 1.8873 (1.2); 1.8759 (1.4); 1.8593 (2.5); 1.8429 (1.4); 1.8315 (1.4); 1.8147 (0.7); 1.5911 (16.0); 1.2933 (0.6); 1.0485 (1.7); 1.0332 (4.6); 1.0264 (5.0); 1.0113 (2.7); 1.0049 (4.8); 0.9985 (4.4); 0.9835 (2.0); 0.7248 (2.1); 0.7095 (5.8); 0.7038 (5.0); 0.6931 (4.6); 0.6873 (5.9); 0.6710 (1.6); 0.1079 (5.2); 0.0483 (0.9); 0.0375 (22.6); 0.0266 (0.9)
I-241:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3033 (0.9); 9.2884 (2.0); 9.2735 (1.0); 7.9613 (2.4); 7.6786 (0.8); 7.6589 (2.3); 7.6391 (1.9); 7.6043 (2.4); 7.5846 (1.4); 7.4729 (3.1); 7.4517 (1.9); 7.4308 (1.5); 7.2951 (2.5); 7.2751 (2.8); 7.0644 (3.2); 6.8888 (1.7); 6.8696 (1.6); 6.2544 (1.8); 6.2301 (2.0); 4.0843 (0.8); 4.0694 (0.8); 4.0453 (1.7); 4.0304 (1.6); 4.0062 (1.0); 3.9911 (0.9); 3.5998 (0.8); 3.5847 (0.6); 3.5751 (0.8); 3.5493 (0.3); 3.3116 (71.7); 2.8993 (16.0); 2.7403 (14.3); 2.5136 (12.0); 2.5093 (16.8); 2.5049 (12.9); 2.4028 (8.2); 2.2232 (11.6); 1.8908 (1.5); 1.8630 (1.7); 1.7219 (1.4); 1.6897 (1.7); 1.5808 (0.8); 1.5521 (0.9); 1.4834 (0.5); 1.4586 (1.4); 1.4277 (1.5); 1.4028 (0.7); 1.2662 (0.5); 1.2355 (1.3); 1.2043 (1.4); 1.1735 (0.7); 1.1457 (0.6); 1.1152 (0.8); 1.0850 (0.6)
I-242:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9961 (0.8); 8.9817 (1.6); 8.9668 (0.9); 7.7402 (6.3); 7.6413 (3.7); 7.6206 (2.3); 7.6009 (1.5); 7.5671 (2.5); 7.5461 (3.2); 7.4991 (1.8); 7.4797 (1.5); 7.4333 (2.6); 7.4007 (3.0); 7.3964 (3.3); 7.3799 (2.7); 7.3752 (2.8); 7.2291 (1.3); 7.0898 (2.7); 6.9505 (1.3); 6.0595 (0.5); 6.0472 (1.0); 6.0341 (0.6); 5.9439 (0.5); 5.9318 (0.9); 5.9185 (0.6); 3.8907 (0.6); 3.8851 (0.7); 3.8751 (1.4); 3.8599 (1.0); 3.8353 (0.7); 3.8203 (1.2); 3.8054 (0.8); 3.3123 (14.2); 2.8988 (1.0); 2.7400 (0.9); 2.6032 (16.0); 2.5132 (6.0); 2.5089 (8.1); 2.5047 (6.2)
I-243:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.3132 (0.8); 8.2568 (3.7); 8.0288 (0.3); 7.7602 (0.8); 7.7415 (2.4); 7.7224 (2.2); 7.6915 (2.9); 7.6729 (4.9); 7.6093 (2.0); 7.5885 (1.6); 7.5273 (1.6); 7.5245 (1.7); 7.5048 (2.3); 7.4026 (3.4); 7.3834 (2.6); 5.7884 (0.5); 4.5936 (0.6); 4.5802 (0.4); 4.3080 (2.2); 4.2916 (3.7); 4.2749 (2.4); 3.4622 (0.5); 3.4501 (0.5); 3.4348 (0.6); 3.3397 (515.8); 3.3363 (593.5); 3.3304 (1011.5); 3.2501 (0.4); 3.1413 (2.0); 3.1254 (3.3); 3.1084 (2.0); 2.6755 (2.8); 2.6710 (3.8); 2.6665 (2.8); 2.5413 (33.3); 2.5243 (9.1); 2.5108 (239.2); 2.5065 (498.4); 2.5020 (665.5); 2.4975 (483.1); 2.4931 (238.8); 2.4451 (16.0); 2.4186 (0.5); 2.4109 (0.5); 2.3332 (2.8); 2.3287 (3.9); 2.3241 (2.9); 2.2922 (0.4); 2.1739 (0.5); 1.2978 (0.4); 1.2585 (0.5); 1.2350 (0.8); -0.0002 (7.7)
I-244:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1630 (1.3); 9.1435 (1.3); 7.9542 (0.5); 7.7907 (6.0); 7.7297 (0.5); 7.7092 (1.6); 7.6903 (1.3); 7.6509 (1.9); 7.6327 (3.5); 7.5707 (1.3); 7.5490 (1.2); 7.4909 (0.4); 7.4847 (3.9); 7.4803 (1.5); 7.4683 (1.6); 7.4636 (5.7); 7.4578 (0.9); 7.3689 (4.9); 7.3477 (3.5); 5.1174 (0.8); 5.0991 (1.2); 5.0809 (0.9); 3.3898 (53.5); 2.8928 (3.2); 2.7345 (2.8); 2.6099 (16.0); 2.5169 (5.0); 2.5125 (10.5); 2.5080 (14.1); 2.5035 (10.2); 2.4991 (4.9); 1.4317 (6.2); 1.4142 (6.2)
I-245:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0478 (2.0); 9.0267 (2.0); 8.1857 (11.7); 7.7487 (0.7); 7.7288 (2.2); 7.7195 (0.4); 7.7086 (2.3); 7.6824 (4.9); 7.6779 (4.1); 7.6337 (1.9); 7.6139 (1.3); 7.2161 (2.8); 7.1965 (3.1); 6.9174 (3.6); 6.8959 (2.0); 6.8761 (1.7); 5.7556 (3.6); 5.1515 (0.4); 5.1378 (0.9); 5.1195 (1.1); 5.1018 (0.5); 3.3219 (58.5); 2.7245 (0.8); 2.7068 (2.0); 2.6912 (2.0); 2.6750 (1.3); 2.6705 (1.0); 2.6658 (0.7); 2.5238 (2.2); 2.5189 (3.4); 2.5104 (42.8); 2.5060 (86.2); 2.5014 (112.5); 2.4968 (80.8); 2.4923 (39.0); 2.3328 (0.5); 2.3282 (0.7); 2.3237 (0.5); 2.2177 (16.0); 2.0181 (0.4); 2.0050 (0.6); 1.9938 (0.6); 1.9827 (0.8); 1.9737 (1.0); 1.9602 (0.6); 1.8824 (0.5); 1.8702 (0.7); 1.8573 (0.7); 1.8375 (0.7); 1.8033 (0.4); 1.7813 (0.9); 1.7770 (0.8); 1.7622 (1.4); 1.7514 (1.7); 1.7391 (1.3); -0.0003 (4.6)
I-246:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.7461 (0.7); 8.7321 (1.3); 8.7178 (0.7); 7.7602 (6.1); 7.7165 (0.6); 7.6970 (1.8); 7.6772 (1.6); 7.6545 (2.1); 7.6349 (1.0); 7.5779 (2.5); 7.5222 (1.4); 7.5023 (1.1); 7.1991 (0.6); 7.1912 (0.8); 7.1847 (0.8); 7.1766 (1.3); 7.1687 (0.8); 7.1620 (0.7); 7.1541 (0.7); 7.1470 (0.6); 7.1354 (0.6); 7.1241 (1.3); 7.1125 (1.3); 7.1010 (0.9); 7.0895 (0.8); 7.0358 (0.4); 7.0266 (0.7); 7.0160 (0.8); 7.0059 (1.1); 6.9972 (0.6); 6.9843 (0.5); 3.5856 (1.0); 3.5690 (2.6); 3.5536 (2.7); 3.5371 (1.0); 3.3292 (41.8); 2.8885 (1.6); 2.8717 (3.1); 2.8549 (1.5); 2.6761 (0.4); 2.6715 (0.6); 2.6673 (0.4); 2.5904 (16.0); 2.5070 (73.4); 2.5027 (91.6); 2.4982 (67.1); 2.3339 (0.4); 2.3294 (0.5); 2.3250 (0.4); -0.0002 (0.3)
I-247:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2795 (16.0); 8.1331 (2.0); 8.1133 (1.2); 7.5136 (5.8); 7.4847 (11.4); 7.4247 (11.8); 7.4004 (9.4); 7.3742 (4.1); 7.3059 (25.6); 7.1014 (3.8); 7.0753 (3.3); 7.0128 (2.6); 7.0072 (3.2); 6.9862 (2.2); 6.9802 (2.9); 6.9416 (4.4); 6.9354 (5.9); 6.9286 (3.3); 5.3450 (5.8); 4.2593 (2.8); 4.2390 (2.7); 4.2123 (5.9); 4.1921 (5.8); 4.1653 (3.0); 4.1450 (2.9); 2.0307 (0.7); 2.0139 (1.4); 2.0025 (1.6); 1.9860 (3.0); 1.9694 (1.7); 1.9581 (1.6); 1.9415 (0.8); 1.5992 (8.5); 1.3536 (0.3); 1.3122 (0.5); 1.2991 (0.6); 1.0981 (1.8); 1.0821 (4.9); 1.0759 (5.3); 1.0608 (2.8); 1.0540 (5.3); 1.0475 (4.9); 1.0329 (2.3); 0.8064 (2.2); 0.7907 (6.5); 0.7849 (5.7); 0.7747 (5.2); 0.7685 (6.7); 0.7524 (1.8); 0.1149 (0.9); 0.0557 (0.9); 0.0450 (25.4); 0.0342 (1.0)
I-248:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1266 (5.0); 7.9036 (0.4); 7.8855 (0.6); 7.8679 (0.4); 7.6500 (0.6); 7.6278 (1.4); 7.6047 (1.7); 7.5821 (0.8); 7.5260 (2.2); 7.4970 (3.7); 7.4243 (4.1); 7.3966 (2.8); 7.3734 (0.5); 7.2984 (6.6); 5.3364 (6.6); 4.2825 (1.0); 4.2620 (1.0); 4.2360 (2.2); 4.2155 (2.1); 4.1895 (1.1); 4.1690 (1.1); 2.7653 (16.0); 1.6067 (6.0); 1.2269 (0.5); 0.0362 (6.4)
I-249:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3968 (0.5); 8.3882 (0.5); 8.0680 (0.6); 8.0595 (0.6); 7.9858 (10.8); 7.9770 (11.0); 7.8213 (11.1); 7.8157 (11.1); 7.7976 (0.9); 7.7924 (0.7); 7.6769 (0.6); 7.6732 (0.6); 7.6611 (0.4); 7.6364 (0.8); 7.6077 (10.2); 7.6026 (7.1); 7.5903 (16.0); 7.5795 (2.1); 7.5764 (1.9); 7.5660 (0.6); 7.5143 (0.4); 7.4855 (1.0); 7.4631 (10.2); 7.4337 (21.1); 7.4033 (1.4); 7.3900 (3.3); 7.3809 (3.1); 7.3756 (5.0); 7.3694 (4.1); 7.3582 (4.1); 7.3466 (15.7); 7.3180 (9.2); 7.2984 (15.9); 7.0106 (2.2); 6.9898 (4.2); 6.9691 (2.2); 6.6232 (7.6); 6.6169 (9.2); 6.6146 (8.7); 6.6083 (7.2); 6.5789 (0.4); 6.5727 (0.5); 6.5642 (0.4); 6.5135 (0.3); 6.5076 (0.4); 4.1012 (3.8); 4.0801 (3.8); 4.0542 (8.2); 4.0331 (8.0); 4.0072 (4.2); 3.9862 (4.3); 3.9673 (0.5); 2.0358 (1.3); 1.6858 (4.4); 1.2953 (0.9); 0.0484 (0.6); 0.0378 (14.6); 0.0269 (0.6)
I-250:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7990 (2.2); 8.6869 (1.6); 8.6705 (1.7); 7.6472 (0.7); 7.6262 (2.2); 7.5848 (1.0); 7.5488 (0.5); 7.5400 (0.8); 7.5327 (0.5); 7.5185 (0.4); 7.2985 (22.1); 7.2730 (1.4); 7.2713 (1.3); 7.2548 (2.1); 7.2275 (1.1); 7.0412 (1.1); 6.9758 (0.6); 6.9475 (0.6); 6.4376 (0.4); 2.3905 (1.7); 2.3837 (3.2); 2.3763 (1.8); 2.3233 (4.3); 1.5876 (16.0); 1.2929 (1.4); 0.9195 (0.4); 0.1070 (1.0); 0.0482 (0.6); 0.0466 (0.4); 0.0450 (0.4); 0.0375 (20.8); 0.0266 (0.8)
I-251:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0184 (1.2); 9.0029 (2.4); 8.9874 (1.2); 8.7096 (3.9); 8.7043 (3.9); 7.9674 (2.8); 7.9615 (4.7); 7.9466 (2.8); 7.9407 (2.7); 7.7137 (4.3); 7.6926 (3.7); 7.6538 (9.7); 7.6180 (1.3); 7.5983 (3.2); 7.5786 (2.1); 7.4852 (2.7); 7.4662 (2.0); 7.3789 (3.8); 7.3379 (2.2); 7.3176 (1.9); 7.2192 (1.8); 7.0799 (3.9); 6.9406 (1.9); 4.2564 (1.2); 4.2408 (1.2); 4.2208 (2.7); 4.2051 (2.6); 4.1851 (1.4); 4.1694 (1.3); 3.3118 (25.4); 2.8986 (16.0); 2.7397 (14.5); 2.5130 (10.2); 2.5087 (13.5); 2.5045 (10.2); 2.3269 (0.5); 2.3146 (1.0); 2.3062 (1.2); 2.2941 (2.0); 2.2819 (1.2); 2.2737 (1.1); 2.2614 (0.5); 1.0942 (0.9); 1.0825 (2.4); 1.0762 (3.7); 1.0679 (2.4); 1.0619 (2.4); 1.0558 (3.3); 1.0477 (1.6); 1.0313 (0.6); 1.0076 (1.7); 0.9991 (3.7); 0.9940 (3.7); 0.9875 (4.1); 0.9814 (3.1); 0.9695 (0.9)
I-252:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4702 (16.0); 8.4341 (6.5); 8.1276 (1.0); 8.1101 (1.6); 8.0918 (1.0); 7.7621 (4.2); 7.7575 (7.0); 7.7528 (4.1); 7.7179 (3.4); 7.7097 (2.9); 7.7054 (3.1); 7.6990 (8.9); 7.6957 (8.4); 7.6844 (0.8); 7.6800 (0.8); 7.6646 (0.4); 7.5728 (3.9); 7.5382 (0.6); 7.5315 (0.5); 7.5231 (1.7); 7.5118 (2.5); 7.5048 (2.4); 7.4922 (2.0); 7.4782 (4.7); 7.4500 (10.6); 7.4327 (0.8); 7.4258 (0.7); 7.3647 (0.5); 7.3576 (0.3); 7.3282 (0.4); 7.2987 (28.4); 7.2877 (3.9); 7.2805 (3.4); 7.2597 (2.7); 7.2529 (2.6); 6.1710 (1.0); 6.1604 (1.1); 6.1469 (1.2); 6.1365 (1.1); 6.0155 (1.0); 6.0050 (1.1); 5.9915 (1.2); 5.9813 (1.1); 4.4022 (0.6); 4.3916 (0.6); 4.3797 (0.7); 4.3689 (0.6); 4.3534 (0.7); 4.3427 (0.8); 4.3309 (0.7); 4.3203 (0.8); 4.3113 (0.7); 4.3004 (0.6); 4.2886 (0.7); 4.2781 (0.6); 4.2623 (0.8); 4.2517 (0.8); 4.2399 (0.8); 4.2293 (0.7); 4.1923 (0.4); 4.1686 (1.2); 4.1447 (1.2); 4.1210 (0.4); 3.9396 (0.7); 3.9225 (0.8); 3.9156 (0.8); 3.8984 (0.8); 3.8908 (0.7); 3.8695 (1.1); 3.8523 (1.1); 3.8287 (0.8); 3.8211 (0.8); 3.8040 (0.6); 3.7969 (0.7); 3.7801 (0.6); 2.0813 (5.7); 2.0472 (1.9); 1.6503 (13.6); 1.3188 (1.7); 1.2949 (3.4); 1.2711 (1.5); 1.1421 (0.7); 1.0522 (0.4); 0.1057 (5.8); 0.0458 (1.0); 0.0350 (25.8); 0.0241 (0.8)
I-253:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3098 (14.5); 7.9547 (1.5); 7.9304 (1.5); 7.7026 (0.3); 7.6747 (5.8); 7.6573 (9.6); 7.6455 (5.2); 7.6227 (3.1); 7.5953 (6.6); 7.5546 (6.4); 7.5321 (2.1); 7.5034 (1.4); 7.4972 (1.9); 7.4881 (1.7); 7.4825 (2.6); 7.4759 (2.1); 7.4666 (1.6); 7.4582 (1.1); 7.3048 (11.2); 5.4822 (0.5); 5.4588 (2.0); 5.4351 (3.0); 5.4114 (2.0); 5.3881 (0.5); 4.1741 (1.0); 4.1503 (1.0); 4.1265 (0.3); 2.0871 (4.3); 1.7042 (16.0); 1.6809 (16.0); 1.6197 (1.2); 1.3256 (1.3); 1.3018 (2.8); 1.2780 (1.2); 0.9634 (0.4); 0.9389 (0.3); 0.0537 (0.3); 0.0429 (10.5); 0.0320 (0.5)
I-254:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6122 (0.5); 7.5860 (3.5); 7.5788 (3.0); 7.5743 (3.1); 7.5675 (8.5); 7.5643 (8.9); 7.5481 (5.7); 7.5193 (8.5); 7.4594 (4.2); 7.4330 (8.1); 7.4039 (6.4); 7.3933 (2.6); 7.3808 (1.8); 7.3725 (1.1); 7.2987 (20.4); 6.4557 (1.0); 6.4350 (2.0); 6.4141 (1.1); 4.2668 (2.2); 4.2457 (2.1); 4.2189 (4.8); 4.1977 (4.5); 4.1709 (2.4); 4.1497 (2.3); 2.7423 (1.9); 2.7172 (6.4); 2.6921 (6.6); 2.6672 (2.0); 1.5946 (14.3); 1.3015 (7.2); 1.2766 (16.0); 1.2514 (6.6); 0.1076 (1.1); 0.0482 (0.7); 0.0374 (20.6); 0.0266 (0.7)
I-255:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0844 (10.0); 8.0427 (0.6); 8.0239 (1.0); 8.0078 (0.6); 7.6778 (0.5); 7.6507 (2.1); 7.6294 (5.9); 7.6123 (0.5); 7.5837 (3.5); 7.5192 (2.6); 7.4600 (1.0); 7.4513 (1.9); 7.4442 (1.3); 7.4371 (0.8); 7.4291 (1.3); 7.4231 (1.3); 7.3955 (4.3); 7.3896 (5.6); 7.3863 (6.3); 7.3584 (0.7); 7.3077 (0.6); 7.2986 (34.0); 6.1275 (0.8); 6.1168 (0.8); 6.1041 (0.9); 6.0934 (0.8); 5.9724 (0.8); 5.9614 (0.9); 5.9486 (0.9); 5.9378 (0.8); 5.3378 (7.1); 4.3544 (0.4); 4.3435 (0.4); 4.3323 (0.4); 4.3212 (0.4); 4.3059 (0.5); 4.2949 (0.5); 4.2837 (0.5); 4.2727 (0.5); 4.2646 (0.5); 4.2541 (0.4); 4.2424 (0.4); 4.2313 (0.4); 4.2159 (0.6); 4.2051 (0.5); 4.1935 (0.6); 4.1828 (0.5); 3.9033 (0.5); 3.8862 (0.6); 3.8795 (0.6); 3.8622 (0.6); 3.8544 (0.5); 3.8374 (0.6); 3.8320 (0.9); 3.8146 (0.9); 3.8092 (0.6); 3.7915 (0.5); 3.7837 (0.5); 3.7664 (0.4); 3.7602 (0.5); 3.7430 (0.4); 2.2941 (0.4); 2.2757 (0.8); 2.2682 (0.9); 2.2599 (0.6); 2.2504 (1.9); 2.2394 (0.7); 2.2319 (0.8); 2.2245 (1.0); 2.2063 (0.5); 2.0450 (16.0); 1.5807 (13.6); 1.2932 (0.5); 1.2092 (1.4); 1.2004 (4.2); 1.1916 (4.6); 1.1868 (6.4); 1.1844 (6.1); 1.1787 (3.6); 1.1664 (2.4); 1.1606 (3.9); 1.1518 (1.8); 1.1295 (0.4); 0.0488 (1.3); 0.0456 (0.8); 0.0380 (37.0); 0.0271 (1.2)
I-256:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2177 (0.4); 9.2023 (0.8); 9.1869 (0.4); 7.9612 (0.9); 7.7155 (0.4); 7.6959 (0.9); 7.6762 (0.8); 7.6467 (1.0); 7.6273 (0.5); 7.4976 (1.3); 7.4859 (0.8); 7.4655 (0.6); 7.3032 (1.1); 7.2832 (1.2); 7.0750 (1.4); 6.9091 (0.7); 6.8892 (0.7); 4.1555 (0.3); 4.1402 (0.4); 4.1178 (0.8); 4.1024 (0.8); 4.0797 (0.4); 4.0644 (0.4); 3.3187 (10.2); 2.9032 (16.0); 2.7399 (5.3); 2.5134 (4.6); 2.5090 (6.4); 2.5047 (4.8); 2.4134 (3.6); 2.2299 (4.9)
I-257:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5453 (1.2); 7.5247 (3.5); 7.5036 (0.3); 7.4232 (1.6); 7.3867 (0.7); 7.3775 (1.4); 7.3706 (2.2); 7.3559 (0.9); 7.3444 (1.9); 7.2985 (10.6); 7.0696 (1.8); 6.9993 (1.5); 6.9741 (1.4); 4.2381 (0.8); 4.2176 (0.8); 4.1880 (1.6); 4.1676 (1.5); 4.1379 (0.8); 4.1175 (0.8); 3.7533 (0.4); 3.7386 (16.0); 3.5733 (0.8); 3.5506 (1.7); 3.5329 (1.8); 3.5103 (0.8); 2.5142 (2.0); 2.4980 (5.6); 2.4911 (6.4); 2.4681 (2.0); 2.3286 (6.9); 2.0838 (0.5); 2.0608 (1.7); 2.0430 (4.7); 2.0380 (2.6); 2.0148 (1.5); 1.9916 (0.4); 1.5954 (4.2); 0.0487 (0.5); 0.0379 (11.1); 0.0270 (0.4)
I-258:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9907 (1.8); 8.9761 (3.7); 8.9613 (2.0); 8.7028 (0.4); 7.9613 (2.6); 7.7598 (7.2); 7.6621 (2.0); 7.6484 (15.2); 7.6311 (2.6); 7.6112 (5.2); 7.5914 (3.5); 7.5344 (2.1); 7.5302 (2.0); 7.5134 (5.8); 7.5092 (6.2); 7.4917 (13.6); 7.4710 (6.8); 7.4220 (5.9); 7.3808 (3.4); 7.3606 (3.3); 7.3114 (2.3); 7.2250 (2.9); 7.0857 (6.2); 6.9465 (3.0); 6.0414 (1.2); 6.0293 (2.4); 6.0162 (1.3); 5.9263 (1.2); 5.9138 (2.3); 5.9007 (1.3); 3.8786 (1.9); 3.8657 (3.6); 3.8515 (2.4); 3.8194 (1.8); 3.8085 (3.4); 3.7942 (2.2); 3.5581 (0.7); 3.5435 (0.7); 3.3115 (36.9); 2.9596 (0.5); 2.9429 (1.0); 2.9256 (0.5); 2.8989 (16.0); 2.7401 (14.6); 2.5132 (17.7); 2.5090 (23.8); 2.5048 (18.7); 2.3305 (0.8); 2.3181 (1.6); 2.3098 (1.9); 2.2976 (3.2); 2.2902 (1.8); 2.2856 (2.2); 2.2774 (2.0); 2.2649 (1.0); 1.1053 (1.4); 1.0938 (4.0); 1.0874 (6.0); 1.0787 (4.1); 1.0733 (4.3); 1.0670 (5.6); 1.0588 (2.9); 1.0428 (1.0); 1.0232 (0.8); 1.0129 (2.5); 1.0044 (5.7); 0.9991 (6.3); 0.9929 (7.0); 0.9868 (5.9); 0.9750 (2.0)
I-259:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2674 (10.5); 8.0861 (1.1); 7.5634 (5.6); 7.5353 (7.5); 7.5116 (7.1); 7.4188 (2.1); 7.3941 (2.9); 7.3879 (0.8); 7.3693 (1.0); 7.3656 (0.6); 7.2985 (20.5); 7.2754 (2.2); 7.2687 (2.1); 7.2475 (5.8); 7.2435 (6.8); 7.2310 (0.6); 7.2184 (4.2); 7.2062 (0.4); 4.4886 (1.8); 4.4681 (1.8); 4.4409 (3.9); 4.4204 (3.8); 4.3930 (2.0); 4.3726 (1.9); 2.0831 (0.7); 1.5829 (16.0); 1.2975 (0.8); 0.1081 (0.8); 0.0492 (0.8); 0.0384 (20.6); 0.0274 (0.6)
I-260:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3093 (5.2); 7.8234 (0.5); 7.8038 (0.3); 7.6838 (0.4); 7.6631 (0.8); 7.6358 (0.9); 7.6071 (1.0); 7.5840 (0.6); 7.4487 (0.7); 7.4218 (1.0); 7.3847 (1.5); 7.3581 (1.6); 7.3019 (16.6); 7.0752 (1.6); 6.9976 (0.9); 6.9701 (0.8); 5.3415 (7.3); 4.3152 (0.8); 4.2952 (0.8); 4.2675 (1.7); 4.2475 (1.7); 4.2198 (0.9); 4.1998 (0.8); 3.5416 (0.9); 3.5235 (0.9); 2.5230 (2.6); 2.5160 (4.8); 2.5087 (2.7); 2.3078 (6.6); 2.0496 (16.0); 1.5957 (11.0); 0.1100 (0.5); 0.0510 (0.5); 0.0403 (15.4); 0.0293 (0.6)
I-261:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2789 (7.1); 7.8560 (1.0); 7.8380 (1.0); 7.6278 (0.3); 7.6072 (4.0); 7.5945 (5.5); 7.4708 (3.1); 7.4495 (1.3); 7.4390 (1.8); 7.4343 (1.5); 7.4274 (1.2); 7.4213 (0.8); 7.2585 (11.1); 7.2378 (5.8); 7.1706 (5.2); 7.1510 (3.4); 5.3357 (0.4); 5.3183 (1.2); 5.3006 (1.8); 5.2829 (1.2); 5.2654 (0.3); 2.3317 (16.0); 2.3174 (0.8); 1.6197 (9.3); 1.6025 (9.2); 1.5833 (1.1); 1.5535 (2.7); -0.0002 (7.1)
I-262:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1968 (1.0); 9.1816 (2.2); 9.1664 (1.2); 8.0174 (0.4); 7.9615 (2.5); 7.6816 (1.0); 7.6620 (2.6); 7.6425 (2.0); 7.6050 (2.7); 7.5855 (1.6); 7.4372 (4.2); 7.4141 (1.8); 7.3031 (2.9); 7.2832 (3.2); 7.0767 (3.8); 6.9378 (2.0); 6.9182 (1.9); 4.1145 (1.0); 4.0986 (1.0); 4.0762 (2.1); 4.0608 (2.0); 4.0382 (1.1); 4.0224 (1.1); 3.6060 (3.0); 3.5905 (8.1); 3.5752 (3.5); 3.3110 (66.0); 2.8993 (16.0); 2.7404 (14.6); 2.5135 (13.1); 2.5093 (18.2); 2.5051 (14.2); 2.4193 (0.7); 2.3987 (9.8); 2.2381 (13.2); 2.2170 (1.1); 1.8311 (3.0); 1.8156 (8.0); 1.7998 (3.3)
I-263:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0692 (1.5); 9.0538 (3.1); 9.0382 (1.5); 7.9613 (0.7); 7.6298 (1.8); 7.6099 (16.0); 7.5901 (3.0); 7.5790 (6.3); 7.5576 (8.7); 7.4930 (3.4); 7.4736 (2.8); 7.4587 (8.4); 7.4375 (6.1); 7.4036 (4.8); 7.3595 (2.7); 7.3392 (2.3); 7.2265 (2.3); 7.0871 (4.9); 6.9479 (2.4); 4.1347 (1.5); 4.1190 (1.6); 4.0998 (3.4); 4.0841 (3.3); 4.0649 (1.7); 4.0492 (1.6); 3.3121 (24.3); 2.8985 (4.4); 2.7398 (4.0); 2.5130 (11.3); 2.5088 (15.0); 2.5047 (11.5); 2.3265 (0.6); 2.3142 (1.3); 2.3058 (1.4); 2.2936 (2.5); 2.2815 (1.6); 2.2734 (1.4); 2.2610 (0.7); 1.0979 (1.1); 1.0863 (3.1); 1.0800 (4.6); 1.0714 (3.0); 1.0658 (3.1); 1.0595 (4.2); 1.0514 (2.0); 1.0356 (0.5); 1.0304 (0.6); 1.0159 (0.6); 1.0069 (2.0); 0.9984 (4.6); 0.9932 (4.6); 0.9869 (5.2); 0.9807 (4.0); 0.9689 (1.2)
I-264:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1230 (5.1); 7.9406 (0.4); 7.9236 (0.7); 7.9067 (0.4); 7.6311 (0.5); 7.6095 (1.0); 7.5872 (0.6); 7.5235 (2.4); 7.4947 (4.1); 7.4219 (4.6); 7.3933 (3.4); 7.3657 (0.6); 7.2987 (6.9); 7.1273 (1.1); 6.9449 (2.2); 6.7626 (1.1); 4.2788 (1.1); 4.2584 (1.0); 4.2322 (2.3); 4.2118 (2.2); 4.1857 (1.1); 4.1652 (1.1); 2.7608 (16.0); 1.6014 (6.1); 1.2949 (0.4); 0.0375 (6.7)
I-265:1 H-NMR(499.9 MHz, CDCl3): δ= 7.3701 (2.1); 7.3541 (2.3); 7.3424 (1.2); 7.3261 (2.5); 7.3182 (0.5); 7.3099 (1.7); 7.3020 (0.4); 7.2598 (15.7); 7.2358 (1.8); 7.2199 (1.4); 7.1781 (0.4); 7.1643 (2.8); 7.1144 (0.7); 7.1025 (1.3); 7.0896 (0.9); 7.0805 (1.6); 7.0769 (1.6); 7.0640 (1.4); 7.0604 (1.4); 7.0484 (0.4); 7.0279 (2.7); 6.9395 (1.5); 6.9238 (1.4); 4.6665 (8.7); 4.1999 (0.9); 4.1875 (1.0); 4.1707 (1.9); 4.1582 (1.9); 4.1412 (1.0); 4.1288 (1.0); 3.7261 (2.2); 3.7178 (2.9); 3.7140 (2.4); 3.7089 (3.0); 3.5522 (2.7); 3.5471 (2.3); 3.5433 (3.0); 3.5350 (2.5); 3.5175 (0.5); 3.4794 (0.3); 3.3439 (16.0); 2.4938 (7.2); 2.3820 (0.3); 2.2923 (0.6); 2.2576 (10.3); 1.5632 (5.5); 1.4138 (0.4); 1.2553 (2.8); 1.1072 (1.2); 0.8804 (0.4); 0.8445 (0.3); -0.0002 (14.2)
I-266:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9180 (2.2); 7.9597 (0.8); 7.5212 (0.8); 7.5016 (1.7); 7.4805 (1.0); 7.3378 (6.3); 7.3172 (4.0); 7.2350 (1.3); 7.2167 (1.0); 7.2124 (0.9); 7.0470 (2.7); 7.0271 (2.4); 3.3276 (161.0); 2.8982 (4.3); 2.7394 (4.0); 2.5650 (10.1); 2.5088 (7.5); 2.2684 (10.1); 2.2509 (9.2); 1.6144 (16.0)
I-267:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.2295 (0.9); 9.2178 (1.8); 9.2058 (1.0); 7.6517 (2.7); 7.5629 (2.6); 7.5460 (3.2); 7.3949 (1.8); 7.3909 (1.8); 7.3782 (1.6); 7.3741 (1.6); 7.1788 (0.8); 7.1630 (2.2); 7.1471 (1.6); 7.1109 (0.9); 7.1082 (1.1); 7.0940 (1.6); 7.0805 (0.7); 7.0778 (0.7); 6.9453 (0.9); 6.9323 (1.6); 6.9189 (0.8); 6.0507 (0.5); 6.0421 (0.8); 6.0311 (0.6); 5.9587 (0.5); 5.9500 (0.8); 5.9390 (0.6); 3.9481 (0.5); 3.9356 (0.9); 3.9305 (0.8); 3.9225 (1.0); 3.9112 (0.6); 3.9007 (0.7); 3.8882 (1.0); 3.8833 (0.8); 3.8752 (1.0); 3.8638 (0.6); 3.3192 (5.6); 2.5084 (2.2); 2.5049 (3.2); 2.5015 (2.5); 2.2614 (16.0); 2.0847 (0.6); 2.0781 (0.7); 2.0680 (1.2); 2.0578 (0.8); 2.0512 (0.7); 2.0408 (0.4); 1.9920 (0.4); 1.0403 (0.8); 1.0314 (2.3); 1.0272 (2.5); 1.0189 (1.4); 1.0146 (2.4); 1.0103 (2.6); 1.0022 (1.0); 0.7971 (0.9); 0.7884 (2.6); 0.7849 (2.9); 0.7786 (2.7); 0.7747 (3.0); 0.7657 (1.0)
I-268:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.7397 (0.6); 8.7255 (1.2); 8.7113 (0.6); 8.0835 (7.9); 7.7511 (0.4); 7.7309 (1.4); 7.7110 (1.6); 7.6964 (3.3); 7.5892 (1.2); 7.5694 (0.9); 6.8436 (2.4); 6.8393 (2.6); 6.7536 (0.8); 6.7492 (0.7); 6.7334 (1.8); 6.7289 (1.7); 6.7042 (3.3); 6.6838 (1.4); 3.9026 (4.1); 3.6965 (16.0); 3.6558 (0.4); 3.6423 (15.8); 3.5436 (0.7); 3.5265 (1.8); 3.5113 (1.9); 3.4943 (0.8); 3.3265 (61.2); 2.7849 (1.4); 2.7673 (2.8); 2.7498 (1.3); 2.6754 (0.5); 2.6710 (0.7); 2.6665 (0.5); 2.5413 (0.9); 2.5242 (2.8); 2.5107 (49.8); 2.5065 (94.9); 2.5020 (119.9); 2.4975 (86.3); 2.4932 (42.7); 2.3333 (0.5); 2.3288 (0.7); 2.3243 (0.5); -0.0002 (0.5)
I-269:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6203 (0.6); 7.5944 (2.8); 7.5741 (8.2); 7.5429 (7.7); 7.5358 (10.6); 7.5259 (9.4); 7.5067 (2.5); 7.4945 (2.3); 7.4853 (2.9); 7.4777 (2.1); 7.4725 (1.5); 7.4636 (2.2); 7.4480 (5.2); 7.4416 (5.4); 7.4302 (4.0); 7.4188 (2.4); 7.4155 (2.7); 7.2986 (8.0); 7.2006 (3.3); 7.1740 (4.0); 7.0236 (4.1); 6.9381 (2.3); 6.9117 (1.9); 6.1478 (1.0); 6.1280 (2.0); 6.1080 (1.1); 3.9828 (1.8); 3.9623 (1.7); 3.9336 (3.8); 3.9132 (3.6); 3.8845 (1.9); 3.8641 (1.8); 2.3872 (12.0); 2.3372 (0.4); 2.2882 (16.0); 1.6548 (0.4); 1.3159 (0.6); 1.2969 (1.0); 0.0505 (0.4); 0.0400 (8.7); 0.0292 (0.5)
I-270:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.8088 (1.6); 8.7948 (3.2); 8.7806 (1.6); 8.0714 (16.0); 8.0706 (15.4); 7.7534 (1.4); 7.7340 (4.4); 7.7144 (4.5); 7.6994 (5.2); 7.6796 (2.0); 7.6452 (5.9); 7.5888 (3.4); 7.5687 (2.6); 7.3850 (1.4); 7.3634 (3.1); 7.3464 (3.1); 7.3248 (1.5); 7.0994 (1.6); 7.0930 (1.7); 7.0737 (2.6); 7.0687 (2.7); 7.0500 (1.7); 7.0436 (1.7); 6.8588 (1.5); 6.8534 (1.5); 6.8376 (2.8); 6.8326 (2.8); 6.8161 (1.4); 6.8114 (1.3); 3.5615 (2.2); 3.5447 (6.1); 3.5293 (6.2); 3.5127 (2.4); 3.3303 (162.0); 2.8747 (3.7); 2.8576 (7.2); 2.8404 (3.3); 2.6762 (0.6); 2.6717 (0.8); 2.5071 (96.4); 2.5026 (126.1); 2.4982 (94.1); 2.3296 (0.7); 1.9891 (1.2); 1.3978 (6.2); 1.1930 (0.3); 1.1755 (0.6); 0.0079 (0.7); -0.0002 (19.0); -0.0079 (0.7)
I-271:1 H-NMR(300.2 MHz, CDCl3): δ= 7.7366 (5.4); 7.6624 (1.5); 7.6360 (10.1); 7.6195 (16.0); 7.5077 (10.4); 7.4836 (1.9); 7.4475 (6.3); 7.4405 (5.3); 7.4214 (8.7); 7.3918 (21.3); 7.3728 (20.6); 7.3442 (5.5); 7.3048 (13.4); 7.3022 (17.4); 7.2970 (31.3); 7.2748 (4.0); 7.2131 (8.1); 7.1902 (7.8); 4.1916 (0.4); 4.1713 (0.4); 4.0685 (3.0); 4.0490 (3.0); 4.0202 (6.1); 3.9999 (5.7); 3.9714 (3.2); 3.9511 (2.9); 2.0553 (0.3); 2.0159 (0.5); 2.0043 (0.4); 1.8586 (1.3); 1.7235 (0.4); 1.4819 (0.4); 1.4583 (0.7); 1.4012 (0.3); 1.3713 (0.7); 1.2934 (6.1); 1.1863 (0.5); 1.1560 (0.4); 1.1373 (0.5); 0.9154 (1.1); 0.8944 (1.1); 0.8690 (0.8); 0.0428 (11.7); 0.0401 (15.5); 0.0348 (28.8); 0.0241 (1.1)
I-272:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2643 (1.3); 9.2492 (2.8); 9.2339 (1.4); 7.9612 (2.5); 7.6863 (1.2); 7.6666 (3.1); 7.6469 (2.6); 7.6150 (3.3); 7.5954 (1.9); 7.5440 (5.4); 7.5226 (7.2); 7.4356 (4.3); 7.4209 (2.8); 7.3914 (7.4); 7.3701 (5.6); 6.2766 (2.5); 6.2525 (2.6); 4.1406 (1.0); 4.1256 (1.1); 4.1043 (2.2); 4.0891 (2.1); 4.0675 (1.3); 4.0521 (1.2); 3.5605 (0.4); 3.5344 (1.0); 3.5186 (0.8); 3.5087 (1.1); 3.4839 (0.4); 3.3120 (98.3); 2.8992 (16.0); 2.7403 (14.3); 2.5136 (16.2); 2.5092 (22.5); 2.5049 (17.2); 1.8689 (2.0); 1.8433 (2.3); 1.7307 (1.9); 1.6988 (2.3); 1.5916 (1.1); 1.5605 (1.2); 1.4838 (0.7); 1.4591 (1.9); 1.4270 (2.0); 1.4017 (0.9); 1.2509 (0.7); 1.2211 (1.8); 1.1890 (2.0); 1.1565 (1.3); 1.1165 (1.2); 1.0862 (0.8)
I-273:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2211 (1.5); 9.2074 (3.2); 9.1933 (1.5); 7.9963 (16.0); 7.9608 (1.6); 7.8686 (6.5); 7.8652 (6.7); 7.6712 (2.0); 7.6516 (4.8); 7.6318 (3.1); 7.5415 (4.1); 7.5220 (3.1); 7.5023 (4.7); 7.4811 (7.4); 7.4446 (5.8); 7.4102 (6.9); 7.3893 (5.2); 7.2475 (2.7); 7.1082 (5.9); 6.9690 (2.9); 4.2954 (1.5); 4.2814 (1.6); 4.2615 (3.2); 4.2468 (3.2); 4.2265 (1.7); 4.2127 (1.6); 3.3114 (35.9); 2.8987 (9.4); 2.7397 (8.4); 2.5130 (15.6); 2.5088 (20.9); 2.5046 (15.9)
I-274:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1771 (3.2); 9.1558 (3.3); 8.2294 (16.0); 7.7495 (1.2); 7.7297 (3.8); 7.7103 (3.8); 7.6909 (6.4); 7.6667 (2.1); 7.6443 (3.4); 7.6247 (2.1); 7.4898 (5.5); 7.4861 (5.7); 7.3420 (3.0); 7.3370 (2.8); 7.3216 (3.5); 7.3166 (3.4); 7.0957 (5.2); 7.0752 (4.4); 5.2002 (0.8); 5.1801 (2.0); 5.1627 (1.5); 5.1470 (0.7); 3.3396 (101.4); 2.7093 (4.4); 2.6937 (2.8); 2.6758 (0.7); 2.6714 (0.8); 2.6666 (0.7); 2.5417 (70.0); 2.5066 (76.4); 2.5023 (100.1); 2.4980 (73.0); 2.3293 (0.5); 2.3245 (0.4); 2.0612 (0.6); 2.0471 (1.4); 2.0366 (1.4); 2.0289 (1.1); 2.0188 (1.4); 2.0045 (0.9); 1.8964 (0.8); 1.8783 (1.2); 1.8652 (1.7); 1.8536 (1.3); 1.8322 (0.5); 1.8169 (0.5); 1.7991 (0.9); 1.7788 (1.5); 1.7646 (2.5); 1.7499 (2.7); 1.7252 (1.1); 1.7021 (0.4); 1.6962 (0.4); -0.0004 (4.3)
I-275:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2783 (0.9); 9.2625 (1.9); 9.2471 (1.0); 8.8532 (6.2); 8.7171 (3.4); 8.7047 (3.6); 8.2810 (0.3); 8.1579 (6.9); 8.0315 (1.5); 7.9596 (2.7); 7.7818 (0.3); 7.7526 (0.3); 7.7257 (3.2); 7.7134 (3.2); 7.6995 (0.8); 7.6801 (1.6); 7.6611 (1.7); 7.6440 (1.7); 7.6278 (1.3); 7.6024 (0.7); 7.5221 (1.4); 7.5021 (2.2); 7.4821 (1.0); 7.4725 (0.6); 7.4543 (1.5); 7.3396 (2.4); 7.3195 (5.4); 7.3070 (0.8); 7.2962 (0.8); 7.1845 (1.4); 7.1613 (0.3); 7.0750 (3.5); 6.9378 (1.8); 6.9189 (1.7); 4.1719 (0.8); 4.1563 (0.9); 4.1355 (1.9); 4.1198 (1.9); 4.0993 (1.3); 4.0833 (1.2); 3.3279 (453.0); 2.8982 (16.0); 2.7392 (14.8); 2.5128 (14.9); 2.5089 (19.4); 2.5050 (14.8); 2.4401 (8.2); 2.3526 (0.5); 2.3053 (0.7); 2.2816 (0.8); 2.1959 (11.5); 2.1663 (0.8)
I-276:1 H-NMR(600.1 MHz, CD3CN): δ= 7.9139 (16.0); 7.6812 (1.1); 7.6681 (3.8); 7.6551 (8.7); 7.6444 (0.9); 7.6418 (1.0); 7.3806 (4.4); 7.2973 (0.4); 7.2785 (1.8); 7.2753 (3.5); 7.2718 (2.5); 7.2633 (3.5); 7.2601 (2.7); 7.2391 (0.4); 7.1961 (0.9); 7.1919 (8.2); 7.1892 (3.3); 7.1780 (10.0); 7.1740 (1.8); 7.0453 (1.2); 7.0409 (11.3); 7.0376 (3.7); 7.0300 (3.0); 7.0267 (9.2); 7.0224 (1.2); 3.3253 (0.9); 3.3176 (1.9); 3.3125 (2.0); 3.3101 (1.3); 3.3049 (3.8); 3.2997 (1.3); 3.2973 (2.1); 3.2922 (2.0); 3.2846 (1.0); 2.4204 (1.2); 2.4079 (2.5); 2.3935 (2.6); 2.3810 (1.3); 2.1325 (35.2); 1.9633 (1.0); 1.9552 (2.3); 1.9511 (2.7); 1.9472 (15.4); 1.9431 (26.9); 1.9390 (39.3); 1.9349 (27.1); 1.9308 (14.0); 1.4302 (2.0); 1.4196 (2.5); 1.4176 (2.5); 1.4152 (2.3); 1.4070 (2.4); 1.4045 (2.7); 1.4026 (2.4); 1.3920 (2.1); 1.3877 (2.1); 1.2424 (2.0); 1.2348 (2.2); 1.2313 (3.2); 1.2237 (3.2); 1.2204 (2.1); 1.2127 (1.8); -0.0001 (2.4)
I-277:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2798 (8.4); 7.8974 (1.0); 7.6259 (4.8); 7.6130 (4.6); 7.4474 (2.9); 7.4305 (0.4); 7.4211 (1.2); 7.4147 (1.2); 7.4082 (1.6); 7.4032 (1.4); 7.3987 (1.1); 7.3924 (0.8); 7.3233 (3.4); 7.2968 (2.5); 7.2861 (1.6); 7.2675 (3.0); 7.2595 (7.6); 7.2485 (2.1); 7.2410 (2.4); 7.2227 (0.8); 4.2218 (1.5); 4.2070 (1.4); 4.1861 (3.0); 4.1713 (3.0); 4.1504 (1.5); 4.1355 (1.5); 2.3340 (16.0); 1.5582 (2.5); -0.0002 (6.2)
I-278:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2497 (0.8); 9.2342 (1.7); 9.2187 (0.8); 8.0383 (7.8); 8.0149 (5.1); 7.9530 (0.4); 7.7505 (4.8); 7.7297 (4.2); 7.6994 (1.8); 7.6795 (2.4); 7.6642 (5.3); 7.6597 (5.2); 7.5845 (1.8); 7.5625 (3.0); 7.5416 (2.9); 7.5133 (0.3); 7.4620 (1.7); 7.4408 (1.1); 7.3402 (0.4); 4.2107 (0.7); 4.1948 (0.7); 4.1736 (1.5); 4.1580 (1.5); 4.1372 (0.8); 4.1211 (0.9); 3.8864 (16.0); 3.3310 (194.3); 2.8914 (2.2); 2.7487 (0.3); 2.7322 (2.0); 2.6759 (0.6); 2.6719 (0.8); 2.6675 (0.6); 2.5526 (7.3); 2.5071 (103.9); 2.5027 (133.0); 2.4984 (98.7); 2.4517 (0.9); 2.3339 (0.6); 2.3292 (0.8); 2.3252 (0.6); 1.2399 (0.8); -0.0002 (0.3)
I-279:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5642 (0.4); 7.5381 (1.6); 7.5172 (7.1); 7.4883 (4.4); 7.4232 (2.2); 7.3974 (4.0); 7.3684 (3.2); 7.3582 (1.7); 7.3509 (1.0); 7.3446 (0.6); 7.3362 (0.9); 7.3292 (0.5); 7.2986 (2.2); 7.0356 (0.6); 7.0149 (1.1); 6.9942 (0.6); 4.2035 (1.0); 4.1825 (1.0); 4.1556 (2.1); 4.1345 (2.0); 4.1076 (1.1); 4.0865 (1.0); 2.7807 (2.6); 2.5718 (9.3); 2.5584 (16.0); 2.2061 (15.8); 1.9799 (0.4); 1.7622 (0.5); 1.2892 (0.4); 0.0326 (2.1)
I-280:1 H-NMR(300.2 MHz, CDCl3): δ= 10.0222 (6.0); 7.6718 (1.9); 7.6521 (3.5); 7.6322 (2.2); 7.6171 (7.2); 7.6119 (6.1); 7.6069 (5.8); 7.5993 (15.2); 7.5960 (16.0); 7.5853 (1.4); 7.5808 (1.3); 7.5636 (0.4); 7.5520 (0.3); 7.5321 (0.4); 7.4791 (1.6); 7.4581 (10.5); 7.4476 (10.5); 7.4185 (20.5); 7.3946 (13.7); 7.3904 (9.9); 7.3783 (5.7); 7.3687 (11.7); 7.3605 (5.0); 7.3519 (2.7); 7.3348 (14.8); 7.3061 (12.0); 7.2986 (16.2); 7.2924 (2.5); 7.2852 (6.5); 7.2781 (1.7); 7.2604 (2.1); 7.1143 (11.3); 7.0891 (9.4); 4.1926 (0.9); 4.1688 (2.7); 4.1449 (2.7); 4.1212 (1.0); 4.1008 (0.4); 4.0284 (4.0); 4.0082 (3.9); 3.9817 (8.6); 3.9615 (8.3); 3.9351 (4.4); 3.9149 (4.2); 3.1937 (0.5); 2.7896 (4.2); 2.0809 (13.1); 1.6715 (0.7); 1.6502 (0.6); 1.6229 (0.4); 1.3472 (0.4); 1.3201 (3.6); 1.2962 (8.9); 1.2725 (3.4); 0.9980 (0.4); 0.9736 (0.7); 0.9489 (0.4); 0.9432 (0.3); 0.9211 (0.9); 0.8975 (0.4); 0.0506 (0.4); 0.0398 (13.7); 0.0287 (0.5)
I-281:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0686 (1.5); 9.0537 (3.2); 9.0387 (1.5); 7.9611 (0.9); 7.6320 (1.9); 7.6069 (16.0); 7.6011 (7.9); 7.5796 (9.9); 7.5060 (10.2); 7.4846 (7.2); 7.4781 (3.4); 7.4078 (5.3); 7.3603 (3.0); 7.3399 (2.6); 7.2282 (2.5); 7.0889 (5.5); 6.9496 (2.7); 4.1280 (1.5); 4.1128 (1.6); 4.0932 (3.3); 4.0780 (3.2); 4.0581 (1.8); 4.0430 (1.6); 3.3118 (30.2); 2.8985 (5.5); 2.7397 (4.9); 2.5130 (13.9); 2.5088 (18.5); 2.5045 (13.9); 2.3267 (0.7); 2.3142 (1.4); 2.3056 (1.6); 2.2935 (2.9); 2.2816 (1.8); 2.2731 (1.5); 2.2609 (0.8); 1.0984 (1.3); 1.0869 (3.4); 1.0805 (5.2); 1.0719 (3.4); 1.0663 (3.5); 1.0600 (4.6); 1.0518 (2.2); 1.0361 (0.6); 1.0303 (0.6); 1.0162 (0.7); 1.0069 (2.2); 0.9984 (5.1); 0.9932 (5.1); 0.9868 (5.7); 0.9807 (4.5); 0.9689 (1.4)
I-282:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8914 (0.5); 8.1878 (1.4); 8.1399 (4.6); 7.7186 (0.8); 7.7153 (0.7); 7.6948 (0.9); 7.6917 (0.9); 7.6882 (0.8); 7.3665 (1.0); 7.3405 (2.2); 7.3141 (1.4); 7.2988 (12.6); 7.2731 (1.4); 7.0395 (1.2); 7.0136 (1.1); 6.9257 (0.8); 6.9227 (0.8); 6.9178 (1.1); 6.9148 (1.0); 6.8993 (0.5); 6.8914 (1.3); 6.8879 (1.5); 6.8841 (1.8); 6.8782 (2.0); 6.8712 (0.9); 6.7172 (1.0); 6.5310 (2.0); 6.3448 (1.0); 5.3368 (2.0); 4.1700 (0.7); 4.1462 (0.7); 4.0358 (0.9); 4.0166 (2.0); 4.0059 (0.7); 3.9959 (2.0); 3.9764 (1.0); 3.2272 (1.2); 3.2068 (1.9); 3.1869 (1.2); 2.7329 (15.0); 2.0825 (3.8); 2.0449 (1.7); 1.9703 (0.5); 1.9592 (0.5); 1.9424 (1.0); 1.9256 (0.6); 1.9143 (0.5); 1.6292 (16.0); 1.3198 (1.0); 1.2959 (2.0); 1.2721 (0.9); 1.0525 (0.7); 1.0373 (1.7); 1.0305 (1.9); 1.0249 (1.0); 1.0155 (1.0); 1.0088 (1.8); 1.0023 (1.6); 0.9876 (0.9); 0.7629 (0.8); 0.7476 (2.1); 0.7415 (1.9); 0.7311 (1.8); 0.7253 (2.3); 0.7091 (0.6); 0.1057 (1.5); 0.0465 (0.4); 0.0358 (12.0); 0.0249 (0.5)
I-283:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1101 (5.1); 7.9129 (0.4); 7.8936 (0.7); 7.8737 (0.4); 7.6676 (1.9); 7.6647 (2.0); 7.6351 (0.5); 7.6115 (1.0); 7.5897 (0.6); 7.5380 (0.5); 7.5099 (2.3); 7.4813 (3.5); 7.4423 (1.8); 7.4364 (1.7); 7.4248 (1.1); 7.4142 (0.9); 7.4082 (0.8); 7.3979 (1.4); 7.3708 (0.5); 7.2987 (9.0); 7.1322 (1.1); 6.9499 (2.2); 6.7675 (1.1); 5.3368 (1.2); 4.5031 (1.0); 4.4824 (1.0); 4.4559 (2.2); 4.4352 (2.1); 4.4086 (1.1); 4.3879 (1.0); 2.7532 (16.0); 1.5970 (8.1); 1.2945 (0.6); 0.1076 (0.7); 0.0482 (0.3); 0.0374 (8.9); 0.0265 (0.4)
I-284:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0486 (0.8); 7.5807 (1.8); 7.5764 (2.6); 7.5719 (1.7); 7.4117 (1.1); 7.3841 (3.9); 7.3679 (2.8); 7.3621 (2.4); 7.3400 (0.7); 7.3341 (0.7); 7.2983 (16.9); 7.1332 (0.5); 7.1250 (0.4); 7.1098 (3.6); 7.0976 (2.0); 7.0937 (2.0); 7.0903 (2.3); 7.0847 (2.9); 7.0669 (0.4); 6.8353 (0.7); 6.8221 (0.7); 6.8146 (1.1); 6.8030 (1.2); 6.7906 (0.6); 6.7814 (0.6); 6.5242 (0.5); 6.5039 (0.8); 6.4836 (0.5); 6.0940 (0.5); 6.0833 (0.6); 6.0725 (0.6); 6.0619 (0.5); 5.9398 (0.5); 5.9286 (0.6); 5.9182 (0.6); 5.9071 (0.5); 4.2207 (0.4); 4.2098 (0.4); 4.1992 (0.4); 4.1875 (0.6); 4.1374 (0.4); 4.1265 (0.4); 4.1158 (0.4); 4.1048 (0.4); 4.0206 (0.4); 4.0005 (0.6); 3.9795 (0.4); 3.9720 (0.3); 3.9510 (0.5); 3.9428 (0.4); 3.9305 (0.3); 3.9227 (0.6); 3.9016 (0.4); 3.8940 (0.3); 3.8734 (0.5); 3.8525 (0.4); 2.9917 (6.8); 2.9179 (5.8); 2.9164 (5.4); 2.6317 (16.0); 2.6191 (1.6); 2.4618 (0.4); 2.3537 (1.3); 2.3368 (15.9); 2.1340 (0.6); 2.1232 (0.6); 2.1057 (1.1); 2.0883 (0.6); 2.0774 (0.6); 2.0602 (0.4); 1.2925 (0.4); 1.0627 (0.8); 1.0476 (2.1); 1.0407 (2.3); 1.0346 (1.2); 1.0261 (1.3); 1.0190 (2.3); 1.0124 (2.1); 0.9979 (1.1); 0.8146 (1.1); 0.7998 (2.5); 0.7969 (2.2); 0.7938 (2.4); 0.7826 (2.2); 0.7772 (2.6); 0.7607 (0.9); 0.0479 (0.7); 0.0371 (20.8); 0.0261 (0.9)
I-285:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5413 (0.4); 7.5256 (2.0); 7.5127 (5.1); 7.4441 (0.5); 7.4320 (2.3); 7.3927 (0.4); 7.3840 (1.0); 7.3792 (1.6); 7.3751 (1.2); 7.3660 (1.1); 7.3492 (0.5); 7.3408 (2.0); 7.3339 (0.6); 7.3248 (2.2); 7.2597 (6.0); 7.0387 (3.0); 6.9582 (2.6); 6.9443 (2.0); 5.2972 (2.1); 4.5276 (1.1); 4.5213 (1.2); 4.5063 (1.5); 4.5000 (1.5); 4.3956 (1.4); 4.3824 (1.5); 4.3744 (1.1); 4.3611 (1.1); 4.2179 (0.6); 4.2052 (0.6); 4.1883 (0.9); 4.1756 (1.0); 4.1538 (1.0); 4.1416 (1.0); 4.1236 (1.3); 4.1119 (1.5); 3.8576 (0.3); 3.5145 (4.7); 3.5038 (4.6); 3.3943 (16.0); 3.3648 (3.0); 3.3529 (1.0); 2.4705 (7.8); 2.2826 (9.8); 1.5840 (1.2); 1.2558 (0.4); -0.0002 (6.1)
I-286:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.8440 (1.2); 8.8297 (2.3); 8.8153 (1.2); 8.3150 (0.5); 8.0710 (16.0); 7.7418 (1.1); 7.7225 (3.4); 7.7030 (3.7); 7.6910 (4.1); 7.6713 (1.4); 7.6376 (4.4); 7.5752 (2.6); 7.5554 (1.9); 7.2116 (1.2); 7.2036 (1.4); 7.1969 (1.4); 7.1889 (2.5); 7.1809 (1.4); 7.1742 (1.3); 7.1663 (1.3); 7.1420 (1.1); 7.1305 (1.2); 7.1192 (2.6); 7.1076 (2.6); 7.0961 (1.7); 7.0846 (1.6); 7.0339 (0.9); 7.0246 (1.4); 7.0141 (1.4); 7.0039 (2.0); 6.9957 (1.1); 6.9822 (0.9); 6.9734 (0.5); 3.9029 (0.9); 3.5966 (1.8); 3.5799 (4.8); 3.5646 (4.9); 3.5481 (1.9); 3.3286 (95.0); 2.8954 (2.8); 2.8785 (5.5); 2.8618 (2.6); 2.6760 (0.8); 2.6714 (1.0); 2.6669 (0.8); 2.6622 (0.4); 2.5249 (3.9); 2.5200 (6.2); 2.5115 (70.3); 2.5071 (137.6); 2.5026 (175.9); 2.4980 (124.7); 2.4935 (59.6); 2.3339 (0.7); 2.3293 (1.0); 2.3248 (0.7); 2.3204 (0.4); 1.3383 (0.4); 1.3206 (0.6); 1.3028 (0.3); 1.2442 (0.4); 1.2349 (0.3); -0.0002 (0.8)
I-287:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2968 (11.8); 7.8416 (0.8); 7.8237 (1.4); 7.8055 (0.8); 7.3728 (3.4); 7.3463 (4.0); 7.3048 (2.9); 7.1670 (1.4); 7.1608 (2.4); 7.1536 (1.7); 7.1396 (1.4); 7.1335 (2.5); 7.1262 (1.7); 7.0908 (5.3); 7.0862 (4.7); 7.0799 (3.8); 7.0737 (1.7); 7.0242 (2.2); 6.9976 (1.9); 6.9514 (1.6); 6.9440 (2.8); 6.9367 (1.4); 6.9222 (1.6); 6.9148 (2.8); 6.9075 (1.4); 4.2977 (1.9); 4.2780 (1.8); 4.2497 (4.0); 4.2299 (3.9); 4.2017 (2.0); 4.1819 (1.9); 2.5121 (11.6); 2.5049 (6.5); 2.3510 (16.0); 1.6531 (4.2); 0.0442 (2.6)
I-288:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0859 (10.8); 8.0260 (1.2); 7.6760 (0.4); 7.6488 (2.3); 7.6282 (6.6); 7.6123 (0.6); 7.5162 (2.9); 7.4801 (0.4); 7.4609 (4.1); 7.4534 (2.4); 7.4462 (1.8); 7.4321 (8.5); 7.4256 (3.9); 7.2986 (70.9); 7.2658 (2.8); 7.2590 (2.6); 7.2380 (2.0); 7.2312 (1.9); 6.9478 (0.4); 6.1430 (0.8); 6.1320 (0.9); 6.1190 (0.8); 6.1083 (0.8); 5.9879 (0.9); 5.9765 (0.8); 5.9640 (0.9); 5.9530 (0.8); 5.3382 (15.6); 4.3547 (0.5); 4.3446 (0.5); 4.3330 (0.4); 4.3215 (0.5); 4.3062 (0.6); 4.2954 (0.7); 4.2837 (0.6); 4.2727 (0.6); 4.2654 (0.6); 4.2539 (0.5); 4.2424 (0.5); 4.2313 (0.5); 4.2163 (0.6); 4.2056 (0.6); 4.1939 (0.7); 4.1829 (0.6); 3.9083 (0.5); 3.8913 (0.6); 3.8849 (0.6); 3.8675 (0.6); 3.8596 (0.5); 3.8368 (1.0); 3.8197 (1.0); 3.7964 (0.6); 3.7885 (0.6); 3.7715 (0.6); 3.7650 (0.6); 3.7478 (0.4); 2.2941 (0.5); 2.2765 (0.8); 2.2678 (1.0); 2.2597 (0.7); 2.2505 (2.1); 2.2396 (0.8); 2.2315 (0.9); 2.2248 (1.1); 2.2061 (0.5); 2.0837 (1.6); 2.0456 (1.5); 1.5762 (16.0); 1.3216 (0.4); 1.2979 (0.8); 1.2096 (1.7); 1.2010 (4.8); 1.1918 (5.2); 1.1871 (7.4); 1.1791 (4.1); 1.1666 (2.8); 1.1609 (4.3); 1.1520 (2.0); 1.1298 (0.4); 0.0492 (3.0); 0.0384 (79.1); 0.0275 (3.1); -0.1600 (0.3)
I-289:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1846 (0.4); 9.1693 (0.8); 9.1540 (0.4); 7.9611 (0.6); 7.7189 (0.3); 7.6991 (1.0); 7.6795 (0.8); 7.6528 (1.0); 7.6333 (0.5); 7.5756 (1.6); 7.5543 (2.2); 7.4724 (1.3); 7.4589 (0.8); 7.4313 (2.4); 7.4099 (1.6); 4.2009 (0.4); 4.1856 (0.4); 4.1649 (0.8); 4.1494 (0.8); 4.1287 (0.4); 4.1132 (0.4); 3.3110 (23.5); 2.9058 (16.0); 2.8994 (5.5); 2.7399 (3.8); 2.5134 (4.4); 2.5091 (6.1); 2.5047 (4.5)
I-290:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0737 (1.2); 9.0585 (2.4); 9.0431 (1.2); 7.9611 (0.6); 7.6277 (1.4); 7.6080 (3.3); 7.5883 (2.2); 7.5678 (10.1); 7.4884 (2.8); 7.4692 (2.1); 7.4021 (4.0); 7.3682 (2.3); 7.3480 (2.0); 7.3242 (3.5); 7.3042 (3.8); 7.2268 (1.9); 7.0870 (7.1); 6.9619 (2.4); 6.9478 (3.0); 4.1144 (1.2); 4.0989 (1.2); 4.0777 (2.6); 4.0621 (2.6); 4.0405 (1.4); 4.0250 (1.3); 3.3119 (21.2); 2.8985 (3.6); 2.7398 (3.2); 2.5130 (9.8); 2.5088 (13.1); 2.5046 (10.0); 2.4245 (11.5); 2.3261 (0.5); 2.3139 (1.1); 2.3055 (1.3); 2.2934 (2.2); 2.2814 (1.4); 2.2729 (1.2); 2.2610 (0.9); 2.2362 (16.0); 2.1863 (0.4); 1.1017 (0.9); 1.0903 (2.6); 1.0838 (3.8); 1.0751 (2.4); 1.0697 (2.7); 1.0634 (3.5); 1.0550 (1.6); 1.0390 (0.5); 1.0262 (0.4); 1.0191 (0.4); 1.0025 (1.6); 0.9938 (3.8); 0.9884 (3.8); 0.9823 (4.2); 0.9761 (3.4); 0.9644 (1.0)
I-291:1 H-NMR(600.4 MHz, d6 -DMSO): δ= 8.7712 (0.8); 8.7615 (1.5); 8.7519 (0.7); 8.1155 (1.2); 8.0769 (9.3); 7.8052 (4.3); 7.8023 (4.4); 7.7212 (3.0); 7.0755 (0.4); 7.0622 (0.4); 7.0538 (2.5); 7.0410 (2.8); 6.9820 (0.4); 6.9426 (2.9); 6.8398 (1.5); 6.8267 (1.4); 5.7519 (1.3); 3.4713 (1.2); 3.4605 (2.2); 3.4475 (2.2); 3.4372 (1.3); 3.4240 (0.3); 3.4088 (0.3); 3.3409 (0.3); 3.3075 (333.4); 3.2861 (0.6); 2.8080 (2.1); 2.7954 (3.3); 2.7835 (2.0); 2.6153 (1.3); 2.6123 (1.8); 2.6093 (1.2); 2.6062 (0.6); 2.5213 (3.2); 2.5182 (3.9); 2.5151 (3.9); 2.5063 (105.8); 2.5033 (221.5); 2.5003 (303.0); 2.4973 (220.7); 2.4943 (104.7); 2.3873 (1.3); 2.3842 (1.8); 2.3812 (1.3); 2.2817 (0.6); 2.2763 (2.1); 2.2646 (16.0); 2.2333 (2.2); 2.2234 (0.6); 2.1938 (13.7); 1.9073 (0.4); 1.2588 (0.4); 1.2366 (0.4); 0.8763 (0.6); 0.8632 (0.5); 0.0053 (0.8); -0.0001 (29.2); -0.0057 (1.0)
I-292:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1727 (1.8); 9.1572 (3.6); 9.1413 (1.7); 8.5198 (16.0); 7.9590 (2.2); 7.8018 (1.3); 7.7825 (4.1); 7.7624 (6.1); 7.7561 (5.9); 7.7365 (1.8); 7.7090 (5.8); 7.6321 (3.6); 7.6132 (2.8); 7.5871 (7.7); 7.5657 (9.6); 7.4239 (9.3); 7.4027 (7.3); 4.1895 (1.8); 4.1738 (1.9); 4.1549 (3.9); 4.1392 (3.8); 4.1200 (2.0); 4.1042 (1.9); 3.3172 (71.1); 2.8968 (14.2); 2.7373 (12.6); 2.6806 (0.8); 2.6763 (1.0); 2.5116 (110.7); 2.5073 (141.1); 2.5030 (102.6); 2.3385 (0.6); 2.3342 (0.8); 2.3298 (0.6)
I-293:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5531 (0.5); 7.5341 (1.5); 7.5150 (3.2); 7.4926 (0.7); 7.4742 (2.2); 7.4329 (1.0); 7.4281 (1.4); 7.4099 (0.9); 7.3216 (0.9); 7.3090 (0.5); 7.2594 (8.3); 7.0747 (1.7); 7.0555 (2.2); 6.9851 (2.4); 6.9376 (1.4); 6.9186 (1.0); 3.7538 (1.1); 3.7365 (2.6); 3.7212 (2.6); 3.7039 (1.1); 3.6803 (1.9); 3.6661 (3.4); 3.6518 (2.0); 3.1548 (16.0); 2.9951 (2.1); 2.9807 (3.4); 2.9667 (1.9); 2.9325 (1.8); 2.9150 (3.4); 2.8974 (1.6); 2.3146 (11.8); 2.3011 (0.5); 2.2701 (10.9); 1.5593 (12.8); -0.0002 (4.8)
I-294:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5688 (0.3); 7.5429 (1.2); 7.5185 (2.8); 7.4904 (0.4); 7.4549 (2.0); 7.4306 (0.9); 7.4235 (1.3); 7.4166 (0.7); 7.3993 (0.9); 7.3905 (2.0); 7.3635 (1.9); 7.2986 (4.2); 7.0856 (1.9); 7.0004 (1.0); 6.9740 (0.9); 6.4226 (0.4); 6.4025 (0.8); 6.3823 (0.5); 4.2819 (0.9); 4.2611 (0.9); 4.2452 (0.4); 4.2333 (2.0); 4.2124 (1.9); 4.1847 (1.1); 4.1638 (1.1); 4.1408 (1.2); 4.1290 (0.4); 4.1258 (0.4); 4.0981 (16.0); 2.5283 (5.9); 2.3794 (0.5); 2.3277 (7.5); 2.2898 (1.1); 2.2246 (15.8); 1.6079 (3.1); 1.2950 (0.7); 0.9202 (0.4); 0.0382 (4.0)
I-295:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9917 (1.8); 8.9774 (3.8); 8.9629 (1.9); 7.9609 (1.9); 7.6527 (16.0); 7.6457 (7.6); 7.6294 (2.4); 7.6095 (5.0); 7.5898 (3.4); 7.5681 (5.6); 7.5471 (7.2); 7.5335 (0.4); 7.4899 (4.3); 7.4707 (3.3); 7.4190 (6.1); 7.4037 (4.7); 7.3988 (4.5); 7.3825 (6.4); 7.3779 (6.6); 7.3601 (3.0); 7.2234 (2.9); 7.0841 (6.1); 6.9448 (3.0); 6.0565 (1.2); 6.0438 (2.3); 6.0309 (1.3); 5.9407 (1.2); 5.9286 (2.2); 5.9153 (1.3); 3.8813 (1.8); 3.8696 (3.6); 3.8552 (2.3); 3.8287 (1.6); 3.8222 (1.7); 3.8133 (3.1); 3.7983 (1.9); 3.3117 (38.9); 2.8986 (11.4); 2.7398 (10.4); 2.5130 (15.9); 2.5088 (21.3); 2.5047 (16.3); 2.3308 (0.8); 2.3184 (1.6); 2.3099 (1.8); 2.2978 (3.2); 2.2858 (2.0); 2.2774 (1.8); 2.2651 (0.9); 1.1048 (1.4); 1.0932 (3.9); 1.0868 (5.8); 1.0782 (3.8); 1.0726 (4.0); 1.0664 (5.2); 1.0582 (2.5); 1.0420 (0.7); 1.0368 (0.7); 1.0219 (0.7); 1.0131 (2.5); 1.0045 (5.7); 0.9992 (5.9); 0.9929 (6.5); 0.9868 (5.2); 0.9749 (1.6)
I-296:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5955 (0.7); 7.5741 (2.4); 7.5383 (1.1); 7.5021 (0.5); 7.4928 (0.8); 7.4854 (0.5); 7.4707 (0.4); 7.4262 (2.0); 7.4047 (0.8); 7.3986 (2.4); 7.2987 (7.2); 7.1871 (1.8); 7.1605 (1.5); 6.3481 (0.9); 2.9875 (0.7); 2.9088 (0.6); 2.4717 (11.0); 2.3629 (6.9); 1.8664 (16.0); 1.5877 (2.4); 0.1091 (0.5); 0.0392 (7.0)
I-297:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0483 (1.2); 9.0337 (2.6); 9.0190 (1.3); 8.3366 (0.8); 8.1057 (16.0); 7.7857 (0.9); 7.7660 (2.8); 7.7466 (2.6); 7.7286 (3.5); 7.7108 (5.7); 7.6253 (2.3); 7.6049 (1.9); 7.5403 (5.5); 7.5197 (7.5); 7.4117 (6.9); 7.3907 (5.1); 5.8117 (0.8); 5.8004 (1.1); 5.7957 (1.0); 5.7844 (0.9); 5.7768 (3.7); 5.6937 (0.8); 5.6829 (1.1); 5.6773 (1.0); 5.6667 (0.9); 5.2375 (0.5); 3.8897 (0.4); 3.8695 (0.8); 3.8537 (1.5); 3.8384 (1.4); 3.8316 (1.1); 3.8284 (1.1); 3.8181 (1.4); 3.8032 (1.3); 3.7959 (0.5); 3.7871 (0.9); 3.7819 (1.0); 3.7676 (1.0); 3.7567 (0.8); 3.7463 (0.3); 3.7317 (0.3); 3.3428 (118.6); 3.3197 (0.4); 2.7025 (0.4); 2.6980 (0.8); 2.6935 (1.1); 2.6889 (0.8); 2.6842 (0.4); 2.5470 (3.1); 2.5423 (4.5); 2.5335 (59.7); 2.5290 (125.1); 2.5243 (174.4); 2.5198 (133.4); 2.5153 (66.2); 2.3603 (0.4); 2.3558 (0.8); 2.3513 (1.1); 2.3467 (0.8); 2.3423 (0.4); 1.2818 (0.5); 1.2569 (6.8); 0.8766 (0.6); 0.0225 (0.6); -0.0002 (2.9)
I-298:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2285 (1.8); 9.2131 (3.6); 9.1974 (1.7); 8.4844 (16.0); 7.9589 (1.9); 7.8676 (6.2); 7.8638 (6.4); 7.8061 (1.4); 7.7865 (4.2); 7.7669 (5.2); 7.7585 (5.7); 7.7388 (1.8); 7.7062 (5.9); 7.6227 (3.4); 7.6034 (2.6); 7.5081 (5.0); 7.4869 (6.9); 7.3799 (3.9); 7.3758 (3.9); 7.3590 (2.9); 7.3546 (2.9); 4.3265 (1.7); 4.3106 (1.8); 4.2917 (3.7); 4.2760 (3.6); 4.2568 (1.9); 4.2411 (1.8); 3.3730 (0.3); 3.3171 (77.4); 2.8969 (12.0); 2.7374 (10.7); 2.6765 (1.0); 2.6717 (0.8); 2.5117 (125.2); 2.5074 (163.0); 2.5031 (119.8); 2.3386 (0.7); 2.3342 (1.0); 2.3298 (0.7)
I-299:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2141 (0.9); 9.1984 (1.9); 9.1826 (0.9); 8.1057 (5.0); 8.0262 (8.7); 7.9525 (2.2); 7.8244 (5.6); 7.7281 (0.6); 7.7080 (1.9); 7.6880 (3.2); 7.6819 (3.0); 7.6670 (3.8); 7.5800 (2.0); 7.5607 (1.4); 7.4808 (3.2); 7.4062 (2.3); 7.3856 (3.4); 7.3121 (1.9); 7.2907 (1.3); 4.1584 (0.9); 4.1430 (0.9); 4.1212 (1.9); 4.1056 (1.8); 4.0841 (0.9); 4.0682 (0.9); 3.8589 (16.0); 3.3250 (70.8); 2.8906 (14.6); 2.7481 (0.4); 2.7313 (12.6); 2.6754 (0.5); 2.6708 (0.6); 2.6663 (0.5); 2.5240 (2.2); 2.5106 (41.5); 2.5063 (81.5); 2.5018 (107.2); 2.4973 (80.2); 2.4930 (40.7); 2.4681 (8.8); 2.3330 (0.5); 2.3286 (0.7); 2.3242 (0.6); 1.2398 (0.9)
I-300:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2364 (16.0); 7.8001 (1.4); 7.7863 (2.4); 7.7722 (1.4); 7.6331 (1.8); 7.6158 (3.4); 7.5983 (2.2); 7.5842 (1.9); 7.5640 (3.7); 7.5464 (2.3); 7.4767 (7.2); 7.4554 (11.5); 7.3886 (11.3); 7.3673 (7.0); 7.2617 (3.0); 4.2208 (2.8); 4.2055 (2.8); 4.1858 (6.0); 4.1705 (5.9); 4.1507 (3.1); 4.1354 (3.0); 1.6068 (1.6); 1.2597 (0.9); -0.0002 (2.3)
I-301:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2264 (0.8); 9.2110 (1.7); 9.1954 (0.8); 7.9612 (2.4); 7.6802 (0.7); 7.6605 (1.9); 7.6408 (1.5); 7.6049 (2.0); 7.5857 (1.1); 7.4689 (2.6); 7.4489 (1.6); 7.4290 (1.3); 7.2999 (2.1); 7.2799 (2.4); 7.0966 (0.4); 7.0847 (1.3); 7.0691 (3.4); 6.9152 (1.4); 6.8958 (1.4); 4.1172 (0.7); 4.1026 (0.7); 4.0794 (1.5); 4.0638 (1.5); 4.0407 (0.8); 4.0254 (0.8); 3.3117 (53.5); 2.8991 (16.0); 2.8142 (6.8); 2.8014 (7.0); 2.7402 (14.4); 2.5136 (9.2); 2.5092 (12.8); 2.5049 (9.9); 2.4036 (7.1); 2.2302 (9.7)
I-302:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1239 (1.2); 9.1040 (1.2); 7.7915 (6.0); 7.7249 (0.6); 7.7052 (1.6); 7.6858 (1.4); 7.6465 (1.8); 7.6259 (3.0); 7.6241 (3.0); 7.5693 (1.3); 7.5481 (1.0); 7.4475 (1.9); 7.4429 (0.9); 7.4336 (2.2); 7.4261 (2.4); 7.4172 (1.0); 7.4121 (2.1); 7.1251 (2.4); 7.1200 (0.8); 7.1083 (0.9); 7.1029 (4.5); 7.0858 (0.7); 7.0806 (2.2); 5.1499 (0.8); 5.1316 (1.2); 5.1134 (0.8); 3.3534 (16.9); 3.3485 (18.8); 3.3447 (19.2); 2.8911 (2.1); 2.7324 (1.9); 2.6073 (16.0); 2.5131 (6.5); 2.5087 (13.8); 2.5042 (18.6); 2.4997 (13.5); 2.4952 (6.5); 1.4371 (6.4); 1.4196 (6.3); -0.0002 (0.4)
I-303:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5862 (11.0); 7.5599 (11.7); 7.4913 (6.9); 7.4160 (5.2); 7.3923 (16.3); 7.3873 (16.2); 7.3585 (1.3); 7.2974 (6.3); 7.1929 (0.5); 7.1685 (0.5); 6.6486 (2.1); 6.6303 (3.4); 6.0629 (1.8); 6.0535 (1.7); 6.0392 (1.9); 6.0303 (1.4); 5.9070 (1.8); 5.8978 (1.7); 5.8835 (1.9); 5.8741 (1.3); 4.2674 (0.8); 4.2577 (0.8); 4.2455 (0.9); 4.2354 (0.8); 4.2183 (1.2); 4.2084 (1.1); 4.1958 (1.2); 4.1862 (1.1); 4.1758 (1.0); 4.1659 (0.9); 4.1538 (1.0); 4.1438 (0.8); 4.1267 (1.2); 4.1168 (1.1); 4.1045 (1.1); 4.0949 (0.8); 3.9308 (0.9); 3.9117 (1.3); 3.8874 (1.2); 3.8594 (1.8); 3.8396 (2.3); 3.8167 (1.5); 3.7913 (1.0); 3.7671 (0.5); 3.1037 (0.4); 3.0812 (0.6); 3.0600 (0.3); 2.8435 (0.4); 2.8179 (1.0); 2.7996 (1.7); 2.7925 (1.8); 2.7753 (4.2); 2.7517 (5.8); 2.7274 (4.2); 2.7091 (1.7); 2.6842 (0.8); 2.0314 (0.5); 1.6537 (1.3); 1.3836 (0.5); 1.3266 (8.1); 1.3017 (16.0); 1.2769 (7.3); 0.0345 (5.9)
I-304:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0363 (1.6); 7.6740 (2.1); 7.6708 (2.1); 7.6684 (2.1); 7.5589 (0.5); 7.5352 (1.1); 7.5153 (0.7); 7.4966 (2.1); 7.4684 (2.9); 7.4380 (0.5); 7.4137 (1.1); 7.4111 (1.1); 7.3901 (0.9); 7.3608 (1.5); 7.3458 (1.6); 7.3391 (2.1); 7.3177 (1.2); 7.3110 (1.4); 7.2985 (15.2); 7.0977 (1.2); 6.9150 (2.4); 6.7324 (1.2); 6.4557 (0.5); 6.4345 (0.9); 6.4132 (0.5); 4.4928 (1.1); 4.4711 (1.0); 4.4454 (2.3); 4.4239 (2.2); 4.3982 (1.2); 4.3766 (1.1); 2.9890 (13.3); 2.9119 (11.8); 2.6448 (0.6); 2.6287 (16.0); 2.3049 (15.8); 1.6140 (3.5); 0.1064 (1.0); 0.0474 (0.6); 0.0366 (14.6); 0.0257 (0.4)
I-305:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2815 (0.7); 8.2781 (0.8); 8.2745 (0.9); 8.2712 (0.7); 8.2544 (0.8); 8.2509 (0.9); 8.2473 (1.0); 8.2440 (0.8); 8.1512 (4.3); 8.1399 (2.1); 8.1326 (1.0); 7.9248 (0.3); 7.9044 (0.6); 7.8860 (0.3); 7.7487 (0.9); 7.7215 (2.1); 7.6943 (1.3); 7.6730 (1.7); 7.6345 (1.1); 7.6310 (1.1); 7.6268 (1.1); 7.6235 (0.9); 7.6072 (0.7); 7.6037 (0.6); 7.5995 (0.7); 7.5962 (0.5); 7.5246 (0.9); 7.4964 (2.7); 7.4711 (1.5); 7.4655 (1.4); 7.4427 (0.5); 7.4372 (0.5); 7.3038 (11.2); 5.3429 (0.4); 4.5082 (0.8); 4.4876 (0.8); 4.4598 (1.6); 4.4393 (1.6); 4.4114 (0.8); 4.3910 (0.8); 2.7765 (12.3); 1.6085 (16.0); 1.3010 (0.4); 1.2950 (0.4); 0.1111 (0.4); 0.0518 (0.3); 0.0410 (9.8)
I-306:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9745 (2.9); 8.9671 (2.9); 8.3872 (7.9); 8.2036 (2.4); 8.1986 (2.5); 8.1610 (2.5); 8.1333 (2.3); 7.8510 (1.5); 7.8240 (1.9); 7.7988 (1.0); 7.7941 (0.9); 7.7757 (1.5); 7.7708 (1.8); 7.7659 (0.9); 7.7476 (1.2); 7.7428 (1.0); 7.6426 (4.5); 7.6394 (4.1); 7.6256 (4.1); 7.6117 (2.2); 7.5984 (0.4); 7.5882 (0.9); 7.5848 (0.8); 7.5220 (2.2); 7.4551 (0.9); 7.4468 (1.0); 7.4372 (1.3); 7.4306 (1.1); 7.4249 (0.8); 7.4164 (0.6); 7.3041 (14.2); 5.3419 (5.4); 4.9718 (4.5); 4.9519 (4.5); 1.6342 (16.0); 0.1126 (0.3); 0.0529 (0.5); 0.0421 (13.1); 0.0312 (0.5)
I-307:1 H-NMR(499.9 MHz, CDCl3): δ= 8.8520 (6.0); 7.9013 (0.5); 7.8898 (0.9); 7.8784 (0.5); 7.6495 (0.4); 7.6337 (1.6); 7.6206 (4.1); 7.6093 (0.4); 7.6077 (0.4); 7.4977 (2.1); 7.4833 (2.7); 7.4661 (3.8); 7.4371 (0.8); 7.4322 (1.4); 7.4279 (0.9); 7.4257 (0.6); 7.4233 (0.6); 7.4192 (1.0); 7.4147 (0.6); 7.3879 (3.6); 7.3709 (2.6); 7.2627 (2.3); 5.2967 (2.5); 4.2296 (0.9); 4.2174 (0.9); 4.2011 (2.0); 4.1890 (1.9); 4.1726 (1.0); 4.1605 (0.9); 4.0683 (16.0); 3.9452 (0.3); 2.3750 (0.5); 2.3619 (15.1); 1.5878 (0.9); -0.0002 (2.2)
I-308:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1918 (1.3); 9.1765 (2.7); 9.1611 (1.3); 7.9612 (1.2); 7.6768 (1.1); 7.6570 (3.2); 7.6372 (2.5); 7.6026 (3.2); 7.5828 (1.7); 7.4505 (4.3); 7.4332 (2.6); 7.4132 (2.0); 7.2901 (3.5); 7.2702 (3.9); 7.0624 (4.4); 6.9041 (2.3); 6.8837 (2.1); 5.7996 (4.1); 5.7854 (4.2); 4.5715 (1.5); 4.5522 (2.5); 4.5306 (2.1); 4.4664 (0.4); 4.4406 (1.4); 4.4259 (1.2); 4.4158 (0.7); 4.1313 (2.6); 4.1222 (2.6); 4.1057 (2.8); 4.0984 (3.2); 4.0853 (1.4); 4.0614 (2.4); 4.0460 (2.3); 4.0229 (1.3); 4.0077 (1.2); 3.3113 (79.2); 2.8990 (7.6); 2.7399 (6.8); 2.5134 (15.7); 2.5090 (21.6); 2.5047 (16.1); 2.4032 (11.6); 2.2479 (0.4); 2.2254 (16.0)
I-309:1 H-NMR(400.2 MHz, CDCl3): δ= 8.2884 (16.0); 7.6225 (2.9); 7.6066 (11.9); 7.5882 (4.7); 7.5685 (1.4); 7.3534 (5.8); 7.3226 (3.4); 7.3016 (13.7); 7.2892 (14.6); 7.2629 (15.1); 7.2230 (3.1); 7.2103 (2.3); 7.2053 (3.3); 6.6469 (3.2); 6.5059 (6.5); 6.3648 (3.2); 3.8571 (2.8); 3.8412 (6.7); 3.8257 (6.7); 3.8095 (2.9); 3.0235 (4.5); 3.0069 (8.3); 2.9902 (4.1); 1.6023 (2.4); 1.2532 (1.6); -0.0001 (10.1); -0.0082 (0.3)
I-310:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1069 (1.4); 9.0869 (1.4); 7.9515 (0.4); 7.7863 (5.0); 7.7231 (0.6); 7.7033 (1.7); 7.6834 (1.4); 7.6510 (4.0); 7.6304 (1.1); 7.5786 (1.4); 7.5587 (1.0); 7.2181 (1.0); 7.1977 (2.3); 7.1775 (1.4); 6.9698 (3.8); 6.9525 (1.7); 6.7936 (1.3); 6.7761 (1.2); 6.7702 (1.2); 5.1281 (0.8); 5.1094 (1.2); 5.0911 (0.8); 3.6567 (16.0); 3.3556 (34.1); 3.3510 (34.1); 3.3477 (32.7); 2.8901 (2.1); 2.7317 (2.0); 2.6061 (13.6); 2.5068 (15.0); 2.5031 (20.0); 2.4990 (15.8); 1.4343 (5.7); 1.4169 (5.7)
I-311:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3533 (2.8); 7.3462 (2.9); 7.2986 (11.0); 7.2419 (2.3); 7.2145 (2.8); 7.1351 (0.5); 7.1077 (2.3); 7.1017 (1.6); 7.0884 (3.6); 7.0810 (1.5); 7.0732 (1.5); 7.0538 (0.4); 6.9914 (1.8); 6.9842 (1.7); 6.9641 (1.4); 6.9569 (1.4); 6.8377 (0.7); 6.8243 (0.7); 6.8164 (0.9); 6.8072 (1.1); 6.7912 (0.6); 6.7840 (0.6); 6.2222 (0.4); 6.2025 (0.7); 6.1838 (0.4); 3.8711 (1.0); 3.8499 (2.8); 3.8280 (2.8); 3.8066 (1.2); 3.1276 (2.0); 3.1054 (3.5); 3.0836 (1.8); 2.6154 (16.0); 2.3523 (15.9); 2.2021 (0.4); 2.1078 (0.5); 2.0967 (0.6); 2.0795 (1.0); 2.0622 (0.6); 2.0511 (0.6); 2.0422 (1.1); 1.6062 (2.5); 1.0613 (0.7); 1.0461 (1.9); 1.0392 (2.1); 1.0332 (1.1); 1.0246 (1.2); 1.0174 (2.1); 1.0107 (1.9); 0.9963 (1.0); 0.8123 (1.0); 0.7974 (2.2); 0.7911 (2.2); 0.7804 (2.0); 0.7748 (2.4); 0.7583 (0.8); 0.1072 (1.0); 0.0482 (0.4); 0.0374 (12.4); 0.0265 (0.5)
I-312:1 H-NMR(400.0 MHz, CD3CN): δ= 7.7417 (1.6); 7.7069 (6.6); 7.7047 (6.6); 7.6964 (16.0); 7.6762 (4.0); 7.6564 (3.6); 7.6375 (4.5); 7.6182 (1.8); 7.5264 (5.1); 7.4719 (4.4); 7.4506 (9.1); 7.4273 (2.4); 7.3808 (3.8); 7.3766 (3.6); 7.3596 (2.4); 7.3554 (2.3); 4.3448 (2.7); 4.3285 (2.7); 4.3112 (5.6); 4.2948 (5.5); 4.2775 (2.8); 4.2611 (2.7); 2.2665 (0.8); 2.2541 (1.6); 2.2457 (1.9); 2.2334 (3.0); 2.2213 (1.9); 2.2130 (1.8); 2.2006 (0.9); 2.1302 (47.6); 2.1130 (1.1); 2.1067 (0.9); 2.1005 (0.6); 1.9635 (4.2); 1.9573 (9.7); 1.9516 (51.2); 1.9455 (94.0); 1.9393 (126.6); 1.9331 (87.6); 1.9270 (45.1); 1.7740 (0.6); 1.7677 (0.7); 1.7616 (0.5); 1.1093 (1.3); 1.1039 (1.3); 1.0967 (3.6); 1.0904 (6.0); 1.0826 (3.3); 1.0759 (3.8); 1.0700 (5.3); 1.0621 (2.9); 1.0572 (1.5); 1.0488 (1.1); 1.0379 (2.9); 1.0301 (6.6); 1.0249 (5.6); 1.0179 (6.3); 1.0116 (4.7); 0.9991 (1.3); -0.0002 (14.0)
I-313:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2708 (0.8); 8.2671 (1.0); 8.2638 (1.0); 8.2605 (0.7); 8.2440 (0.9); 8.2401 (1.1); 8.2369 (1.1); 8.2335 (0.8); 8.1779 (4.2); 8.1423 (1.3); 8.1352 (2.1); 8.1280 (1.1); 7.9416 (0.7); 7.9226 (0.4); 7.7338 (0.9); 7.7066 (2.1); 7.6797 (1.5); 7.6422 (1.3); 7.6384 (1.4); 7.6346 (1.3); 7.6312 (1.0); 7.6150 (0.6); 7.6112 (0.6); 7.6074 (0.7); 7.6039 (0.5); 7.3856 (1.6); 7.3589 (1.8); 7.3040 (10.7); 7.0845 (1.9); 7.0149 (1.1); 6.9883 (0.9); 5.3431 (1.8); 4.3221 (0.9); 4.3025 (0.8); 4.2736 (1.8); 4.2539 (1.7); 4.2251 (0.9); 4.2053 (0.9); 2.7774 (13.0); 2.5218 (5.4); 2.3275 (7.6); 1.6100 (16.0); 0.1120 (0.3); 0.0524 (0.4); 0.0417 (9.2); 0.0308 (0.3)
I-314:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3173 (15.8); 8.0135 (1.2); 7.9938 (2.2); 7.9750 (1.3); 7.6882 (7.3); 7.6710 (9.2); 7.6460 (0.4); 7.5472 (4.9); 7.5161 (0.6); 7.5038 (2.2); 7.4941 (2.0); 7.4879 (2.8); 7.4814 (2.5); 7.4732 (1.8); 7.4652 (1.3); 7.4327 (4.9); 7.4057 (5.4); 7.3039 (13.7); 7.0301 (5.6); 6.9468 (3.1); 6.9198 (2.8); 4.3067 (2.3); 4.2867 (2.3); 4.2580 (4.9); 4.2381 (4.6); 4.2093 (2.5); 4.1894 (2.4); 3.9643 (0.5); 2.5430 (16.0); 2.4086 (0.6); 2.3697 (1.0); 2.3518 (1.8); 2.3362 (1.9); 2.3210 (1.9); 2.3023 (1.2); 1.8630 (0.7); 1.8439 (1.3); 1.8328 (1.1); 1.8279 (1.2); 1.8218 (1.4); 1.8174 (1.4); 1.8143 (1.4); 1.8064 (1.0); 1.7983 (1.3); 1.7955 (1.3); 1.7764 (0.9); 1.6142 (1.7); 1.4666 (1.6); 1.4476 (3.0); 1.4344 (1.8); 1.4288 (1.8); 1.4161 (2.8); 1.3970 (1.5); 1.3773 (0.4); 1.3515 (0.5); 1.3282 (0.8); 1.2993 (2.8); 1.2214 (1.3); 1.2012 (2.2); 1.1918 (1.5); 1.1884 (1.4); 1.1820 (1.4); 1.1717 (2.0); 1.1521 (1.0); 0.9242 (0.4); 0.9000 (0.4); 0.1149 (1.4); 0.0539 (0.6); 0.0432 (13.5); 0.0323 (0.5)
I-315:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2186 (6.5); 7.7852 (0.6); 7.7711 (1.1); 7.7570 (0.6); 7.6279 (3.3); 7.6003 (1.1); 7.5749 (1.6); 7.5572 (1.0); 7.4706 (1.7); 7.4494 (3.9); 7.4208 (2.4); 7.4172 (2.3); 7.4064 (1.3); 7.4004 (1.3); 7.3959 (1.2); 7.3865 (1.8); 7.3661 (0.8); 7.2657 (1.4); 4.4427 (1.2); 4.4271 (1.2); 4.4072 (2.5); 4.3916 (2.4); 4.3717 (1.3); 4.3561 (1.2); 1.9938 (16.0); 1.6170 (0.5); 1.2598 (0.6); -0.0002 (1.0)
I-316:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1925 (1.3); 9.1769 (2.6); 9.1616 (1.3); 8.7769 (5.7); 8.7622 (5.9); 8.4613 (8.3); 8.1081 (6.1); 8.0932 (5.8); 7.9591 (2.9); 7.7898 (1.0); 7.7704 (2.8); 7.7508 (2.8); 7.7282 (3.7); 7.7066 (5.5); 7.6428 (2.6); 7.6228 (2.0); 7.3481 (3.3); 7.3281 (3.6); 7.0857 (4.4); 6.9282 (2.4); 6.9087 (2.2); 4.1837 (1.3); 4.1685 (1.3); 4.1468 (2.7); 4.1313 (2.6); 4.1097 (1.4); 4.0941 (1.2); 3.3186 (40.9); 2.8965 (16.0); 2.7374 (14.8); 2.6764 (0.7); 2.5111 (86.0); 2.5074 (106.8); 2.4412 (11.7); 2.3342 (0.7); 2.2197 (15.6)
I-317:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.5163 (0.3); 7.3064 (0.3); 7.0974 (0.3); 5.7792 (2.0); 3.9609 (2.7); 3.3470 (16.0); 2.5338 (1.3); 2.5279 (2.7); 2.5218 (3.7); 2.5158 (2.6); 2.5099 (1.2); 2.4408 (2.6); 2.4301 (1.0); 2.2524 (1.2); 0.0200 (2.1)
I-318:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0374 (1.1); 9.0163 (1.1); 8.1747 (5.2); 7.7497 (0.4); 7.7308 (1.2); 7.7102 (1.2); 7.6834 (3.8); 7.6651 (0.8); 7.6319 (1.2); 7.6127 (0.8); 7.2428 (1.1); 7.2214 (1.3); 6.6695 (4.4); 6.6509 (1.3); 6.6443 (0.8); 5.1224 (0.6); 5.1050 (0.6); 3.6947 (16.0); 3.3815 (19.9); 3.3749 (23.8); 3.3710 (22.9); 3.3661 (26.3); 2.7448 (0.5); 2.7265 (1.1); 2.7105 (1.0); 2.6949 (0.5); 2.5143 (4.4); 2.5099 (9.3); 2.5054 (12.4); 2.5009 (8.9); 2.4964 (4.3); 1.9820 (0.4); 1.9695 (0.5); 1.9605 (0.5); 1.9466 (0.4); 1.8780 (0.3); 1.8661 (0.3); 1.8514 (0.4); 1.8324 (0.4); 1.8124 (0.4); 1.7924 (0.5); 1.7866 (0.4); 1.7610 (0.7); 1.7451 (0.8); -0.0002 (0.4)
I-319:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1820 (1.0); 9.1673 (1.8); 9.1521 (0.9); 8.8556 (5.6); 8.7191 (3.1); 8.7067 (3.2); 8.2433 (6.6); 8.1088 (1.5); 7.9594 (2.6); 7.7574 (3.8); 7.7359 (2.9); 7.7235 (3.4); 7.7031 (1.4); 7.6842 (0.8); 7.6632 (0.7); 7.6447 (1.6); 7.6285 (1.3); 7.6068 (0.4); 7.5464 (0.7); 7.5422 (0.6); 7.5250 (3.8); 7.5217 (4.0); 7.5128 (4.9); 7.5028 (2.3); 7.4922 (1.3); 7.4829 (0.9); 7.4537 (1.2); 7.3186 (2.4); 7.2950 (0.6); 7.1837 (1.2); 6.0935 (0.5); 6.0828 (0.7); 6.0686 (0.5); 5.9780 (0.5); 5.9677 (0.7); 5.9536 (0.5); 3.9723 (0.4); 3.9565 (0.7); 3.9400 (0.5); 3.9198 (0.7); 3.8990 (1.0); 3.8841 (0.7); 3.8721 (0.5); 3.8633 (0.6); 3.8503 (0.7); 3.8396 (0.5); 3.8276 (0.4); 3.3271 (461.8); 3.2757 (0.4); 2.8981 (16.0); 2.7390 (14.6); 2.5129 (14.0); 2.5087 (18.4); 2.5046 (13.6)
I-320:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.3444 (1.8); 9.3255 (1.8); 8.1952 (8.4); 8.1921 (4.0); 8.1911 (4.0); 7.7539 (0.8); 7.7344 (2.4); 7.7136 (2.3); 7.6881 (7.6); 7.6678 (2.5); 7.6420 (16.0); 7.6172 (2.3); 5.2152 (1.2); 5.1972 (1.8); 5.1792 (1.2); 3.4040 (35.2); 3.3907 (39.7); 3.3806 (47.6); 2.8945 (1.8); 2.7361 (1.6); 2.5318 (0.4); 2.5186 (8.4); 2.5141 (17.7); 2.5096 (23.8); 2.5051 (17.2); 2.5006 (8.3); 1.4859 (9.2); 1.4683 (9.1)
I-321:1 H-NMR(600.4 MHz, d6 -DMSO): δ= 9.1468 (1.4); 9.1364 (2.8); 9.1261 (1.4); 8.0390 (16.0); 7.7494 (1.4); 7.7363 (3.6); 7.7230 (2.9); 7.6991 (3.6); 7.6861 (1.9); 7.6505 (4.4); 7.5921 (2.5); 7.5782 (2.0); 7.5543 (5.5); 7.5419 (6.5); 7.4644 (1.1); 7.4521 (3.3); 7.4399 (2.4); 7.4043 (4.6); 7.3915 (6.3); 7.3791 (2.4); 5.7520 (7.4); 4.1340 (1.4); 4.1235 (1.5); 4.1100 (3.4); 4.0995 (3.4); 4.0860 (1.6); 4.0755 (1.5); 3.3064 (283.7); 2.6152 (1.8); 2.6122 (2.4); 2.6091 (1.8); 2.6061 (0.8); 2.5211 (6.3); 2.5180 (8.8); 2.5148 (11.5); 2.5062 (154.6); 2.5032 (306.4); 2.5002 (411.0); 2.4971 (298.7); 2.4941 (141.4); 2.3902 (0.9); 2.3871 (1.8); 2.3841 (2.4); 2.3811 (1.7); 2.3783 (0.8); 0.0053 (0.8); -0.0001 (18.0); -0.0056 (0.6)
I-322:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2125 (1.6); 9.1966 (3.4); 9.1811 (1.6); 8.0193 (16.0); 7.7647 (1.4); 7.7451 (10.2); 7.7256 (4.1); 7.7097 (5.0); 7.6900 (2.0); 7.6272 (5.6); 7.5705 (6.2); 7.5630 (3.6); 7.5492 (7.5); 7.2415 (3.3); 7.2367 (3.3); 7.2204 (3.0); 7.2155 (3.0); 4.3037 (1.7); 4.2877 (1.7); 4.2691 (3.7); 4.2533 (3.6); 4.2345 (1.9); 4.2187 (1.8); 3.3453 (160.3); 3.3389 (155.7); 3.3371 (144.2); 2.6769 (0.4); 2.6724 (0.6); 2.6682 (0.5); 2.5429 (72.5); 2.5256 (2.2); 2.5122 (42.4); 2.5081 (85.0); 2.5037 (112.0); 2.4993 (81.0); 2.3352 (0.5); 2.3307 (0.6); 2.1967 (0.7); 1.2340 (0.4); -0.0002 (2.2)
I-323:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.6720 (1.4); 8.6574 (2.8); 8.6429 (1.4); 8.3164 (0.3); 8.0392 (16.0); 7.7500 (1.2); 7.7306 (3.7); 7.7109 (3.9); 7.6985 (4.6); 7.6786 (1.6); 7.6249 (5.0); 7.5450 (2.8); 7.5255 (2.2); 7.2797 (6.6); 7.2586 (10.9); 7.1976 (11.7); 7.1765 (6.9); 3.9028 (2.7); 3.5197 (0.4); 3.5037 (0.8); 3.4868 (2.2); 3.4706 (4.4); 3.4549 (4.1); 3.4368 (2.3); 3.4186 (0.8); 3.4034 (0.6); 3.3299 (155.0); 3.0627 (1.1); 3.0450 (2.2); 3.0273 (2.2); 3.0098 (1.1); 2.9849 (0.3); 2.6760 (1.0); 2.6715 (1.3); 2.6670 (1.0); 2.5246 (5.7); 2.5070 (178.6); 2.5026 (220.8); 2.4981 (159.0); 2.3337 (1.0); 2.3294 (1.3); 2.3250 (1.0); 1.2985 (0.3); 1.2672 (0.4); 1.2585 (0.4); 1.2325 (13.6); 1.2150 (13.0); -0.0002 (0.8)
I-324:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1899 (0.7); 9.1774 (1.4); 9.1649 (0.7); 8.8468 (4.4); 8.7087 (2.5); 8.6989 (2.7); 8.1538 (5.5); 8.0164 (0.4); 7.9540 (2.5); 7.7877 (0.6); 7.7720 (1.6); 7.7563 (1.4); 7.7413 (2.3); 7.7313 (1.9); 7.7153 (3.4); 7.7054 (2.6); 7.6672 (1.3); 7.6517 (1.1); 7.3252 (1.9); 7.3092 (2.2); 7.0717 (2.3); 6.9066 (1.2); 6.8906 (1.2); 4.1625 (0.6); 4.1500 (0.6); 4.1332 (1.4); 4.1207 (1.3); 4.1039 (0.7); 4.0914 (0.7); 3.3184 (11.9); 2.8911 (16.0); 2.7325 (14.3); 2.5058 (3.4); 2.5024 (4.6); 2.4990 (3.4); 2.4273 (6.0); 2.2076 (9.2); -0.0002 (1.8)
I-325:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9285 (0.7); 8.9139 (1.4); 8.8992 (0.7); 8.1175 (7.0); 7.7646 (0.5); 7.7441 (1.7); 7.7243 (1.7); 7.7072 (2.2); 7.6912 (3.3); 7.6064 (1.5); 7.5860 (1.1); 7.3348 (2.0); 7.3233 (0.6); 7.3133 (2.1); 6.7648 (1.3); 6.7602 (2.6); 6.7532 (3.4); 6.7486 (3.8); 6.7441 (2.8); 6.7397 (1.1); 5.7551 (16.0); 4.6537 (1.1); 4.6308 (2.6); 4.6079 (1.4); 4.4551 (1.4); 4.4412 (1.4); 4.4320 (1.1); 4.4180 (1.1); 3.7556 (0.6); 3.7397 (0.8); 3.7335 (0.7); 3.7175 (0.7); 3.5908 (0.4); 3.5725 (1.1); 3.5579 (2.3); 3.5430 (2.0); 3.5276 (1.0); 3.3207 (42.7); 2.6752 (0.4); 2.6709 (0.5); 2.6666 (0.4); 2.5063 (63.5); 2.5019 (82.0); 2.4976 (61.0); 2.3332 (0.4); 2.3286 (0.5); 1.9888 (0.6); 1.3559 (1.0); 1.2353 (0.4); 1.1752 (0.4); 0.0079 (0.7); -0.0001 (16.0); -0.0079 (0.7)
I-326:1 H-NMR(499.9 MHz, CDCl3): δ= 9.2745 (0.3); 9.2540 (16.0); 7.5865 (0.9); 7.5708 (3.4); 7.5573 (9.5); 7.5515 (6.0); 7.5442 (1.1); 7.5344 (5.8); 7.4798 (4.4); 7.4760 (4.5); 7.4671 (0.4); 7.4411 (4.0); 7.3961 (0.4); 7.3848 (1.6); 7.3797 (3.2); 7.3754 (2.0); 7.3724 (1.1); 7.3705 (1.2); 7.3666 (2.1); 7.3618 (1.2); 7.2604 (24.5); 7.1721 (2.9); 7.1680 (2.8); 7.1551 (2.6); 7.1511 (2.6); 6.3500 (1.0); 6.3375 (1.9); 6.3251 (1.0); 4.4383 (2.2); 4.4254 (2.1); 4.4096 (4.7); 4.3968 (4.5); 4.3809 (2.4); 4.3681 (2.2); 2.0011 (0.5); 1.5542 (18.5); 1.2648 (0.6); 1.2553 (0.7); 0.8818 (0.7); 0.8675 (0.3); 0.0063 (1.0); -0.0002 (25.2); -0.0068 (1.0)
I-327:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1371 (1.2); 9.1215 (2.5); 9.1059 (1.2); 7.9737 (13.3); 7.9522 (1.6); 7.6923 (1.5); 7.6885 (1.8); 7.6803 (2.6); 7.6738 (1.9); 7.6706 (1.8); 7.6666 (1.9); 7.6326 (3.2); 7.6276 (5.2); 7.3070 (3.8); 7.2871 (8.2); 7.2816 (3.9); 7.2773 (6.8); 7.2743 (6.6); 7.2659 (0.6); 7.2611 (0.5); 7.0759 (4.3); 6.9332 (2.2); 6.9131 (2.0); 4.1191 (1.2); 4.1034 (1.2); 4.0823 (2.7); 4.0666 (2.6); 4.0454 (1.4); 4.0297 (1.3); 3.3326 (59.6); 2.8920 (11.1); 2.7333 (9.8); 2.5256 (1.0); 2.5122 (19.2); 2.5079 (37.8); 2.5034 (49.0); 2.4989 (35.7); 2.4946 (17.6); 2.4147 (11.2); 2.2418 (16.0); 1.2400 (1.2); -0.0002 (1.4)
I-328:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2052 (1.7); 9.1897 (3.6); 9.1741 (1.7); 8.0308 (15.6); 7.7605 (1.4); 7.7411 (4.2); 7.7215 (4.1); 7.7046 (4.9); 7.6850 (2.0); 7.6471 (5.5); 7.5826 (3.3); 7.5630 (2.5); 7.4331 (5.2); 7.4118 (5.9); 7.3688 (5.5); 7.1459 (3.0); 7.1424 (3.0); 7.1251 (2.6); 7.1213 (2.6); 4.1622 (1.7); 4.1465 (1.8); 4.1257 (3.8); 4.1100 (3.6); 4.0891 (1.9); 4.0733 (1.8); 3.3227 (237.7); 3.2863 (0.4); 2.6751 (0.7); 2.6706 (0.9); 2.6665 (0.7); 2.5410 (58.8); 2.5061 (100.3); 2.5016 (133.1); 2.4972 (103.8); 2.4562 (16.0); 2.3327 (0.6); 2.3284 (0.8); 2.3239 (0.6); -0.0002 (0.4)
I-329:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.7603 (6.6); 8.3162 (0.8); 8.0247 (16.0); 7.7557 (1.3); 7.7363 (4.0); 7.7168 (4.2); 7.7042 (5.0); 7.6847 (1.8); 7.5976 (5.4); 7.5533 (3.1); 7.5339 (2.4); 7.2748 (8.5); 7.2539 (10.6); 7.2393 (0.8); 7.1053 (11.8); 7.0844 (9.2); 3.9025 (1.1); 3.3263 (259.7); 2.9016 (14.2); 2.6753 (2.4); 2.6710 (3.1); 2.6665 (2.2); 2.5242 (11.5); 2.5105 (218.6); 2.5065 (413.6); 2.5020 (518.4); 2.4975 (370.7); 2.4934 (181.2); 2.3333 (2.2); 2.3288 (3.0); 2.3244 (2.2); 1.2356 (0.4); 0.9055 (2.2); 0.8878 (7.7); 0.8767 (3.3); 0.8492 (0.4); 0.8377 (0.6); 0.8274 (0.6); 0.7880 (3.2); 0.7770 (7.3); 0.7594 (2.1); -0.0002 (2.8)
I-330:1 H-NMR(400.1 MHz, CDCl3): δ= 7.6095 (0.8); 7.5904 (0.8); 7.5374 (0.4); 7.5181 (1.4); 7.4983 (3.0); 7.4777 (3.1); 7.4574 (1.1); 7.4528 (1.5); 7.4478 (0.8); 7.4341 (0.8); 7.2965 (2.8); 7.2764 (3.9); 7.2596 (8.9); 7.1936 (0.4); 7.1754 (3.4); 7.1556 (2.4); 5.2825 (0.8); 5.2645 (1.2); 5.2465 (0.8); 3.8111 (0.4); 3.8000 (0.5); 3.7933 (0.6); 3.7881 (0.8); 3.7822 (0.7); 3.7773 (0.8); 3.7702 (0.8); 3.7593 (0.6); 3.7108 (0.6); 3.6996 (0.8); 3.6935 (0.8); 3.6876 (0.6); 3.6824 (0.8); 3.6764 (0.6); 3.6707 (0.5); 3.6593 (0.4); 3.2424 (1.1); 3.2332 (16.0); 3.0592 (0.4); 3.0532 (0.4); 3.0417 (0.4); 3.0353 (0.9); 3.0244 (1.0); 3.0183 (1.1); 3.0100 (1.2); 3.0078 (1.1); 2.9992 (1.1); 2.9925 (0.9); 2.9813 (0.8); 2.9759 (0.4); 2.3580 (0.8); 2.3407 (10.8); 1.6010 (6.6); 1.5837 (6.5); 1.5593 (11.3); -0.0002 (4.9)
I-331:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1462 (2.0); 9.1253 (2.3); 9.1024 (0.3); 8.2182 (10.8); 7.7483 (0.9); 7.7290 (2.7); 7.7094 (2.7); 7.6884 (6.5); 7.6676 (1.6); 7.6270 (2.3); 7.6078 (1.4); 7.4824 (3.9); 7.3553 (1.5); 7.3517 (1.5); 7.3351 (2.8); 7.3317 (2.8); 7.3140 (0.5); 7.2787 (4.0); 7.2587 (2.5); 7.2258 (0.4); 7.1538 (0.3); 5.4774 (0.6); 5.4576 (1.9); 5.4376 (1.9); 5.4178 (0.6); 4.0383 (0.5); 4.0205 (0.5); 3.3207 (41.0); 3.0034 (0.4); 2.9957 (0.5); 2.9820 (0.5); 2.9737 (0.6); 2.9631 (1.0); 2.9553 (1.2); 2.9413 (1.1); 2.9333 (1.1); 2.9113 (0.7); 2.8903 (1.5); 2.8698 (1.1); 2.8498 (0.7); 2.8287 (0.4); 2.6754 (0.4); 2.6707 (0.6); 2.6663 (0.4); 2.5062 (74.4); 2.5018 (96.6); 2.4974 (72.8); 2.4776 (1.9); 2.4687 (1.2); 2.4576 (0.7); 2.4494 (0.5); 2.3330 (0.4); 2.3287 (0.6); 2.3243 (0.4); 1.9888 (2.1); 1.9584 (0.4); 1.9367 (1.3); 1.9270 (0.5); 1.9158 (1.4); 1.9051 (1.2); 1.8941 (0.7); 1.8844 (1.2); 1.8625 (0.5); 1.3978 (16.0); 1.1929 (0.6); 1.1751 (1.1); 1.1572 (0.5); 0.0080 (0.5); -0.0002 (12.4)
I-332:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0377 (1.4); 9.0177 (1.4); 8.1195 (7.3); 7.7179 (0.5); 7.6985 (1.8); 7.6791 (2.0); 7.6679 (2.3); 7.6527 (2.4); 7.6331 (2.1); 7.6100 (2.4); 7.5607 (1.4); 7.5413 (1.0); 7.3851 (2.1); 7.3645 (2.4); 7.3110 (4.5); 7.1229 (1.0); 7.1050 (1.8); 7.0848 (1.0); 6.8868 (1.2); 6.8688 (2.0); 6.8493 (1.0); 5.4415 (0.8); 5.4237 (1.2); 5.4053 (0.8); 3.7164 (16.0); 3.3816 (40.4); 3.3772 (58.2); 3.3751 (58.9); 3.3725 (57.4); 2.8901 (0.4); 2.7321 (0.3); 2.5132 (6.4); 2.5088 (13.5); 2.5043 (18.2); 2.4997 (13.2); 2.4953 (6.4); 1.6142 (5.9); 1.5972 (5.8)
I-333:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4518 (8.3); 7.6191 (0.6); 7.5932 (2.3); 7.5710 (8.5); 7.5439 (4.8); 7.5224 (3.2); 7.5163 (3.2); 7.4671 (3.1); 7.4234 (1.3); 7.4156 (2.2); 7.4084 (1.2); 7.3925 (1.4); 7.2985 (19.0); 7.2108 (2.1); 7.2041 (2.0); 7.1825 (1.8); 7.1758 (1.7); 6.5053 (0.8); 6.4836 (1.5); 6.4628 (0.8); 4.5058 (1.6); 4.4843 (1.6); 4.4577 (3.5); 4.4362 (3.4); 4.4096 (1.8); 4.3881 (1.7); 2.0808 (0.4); 2.0518 (0.4); 2.0349 (0.8); 2.0235 (0.9); 2.0070 (1.8); 1.9903 (1.0); 1.9791 (1.0); 1.9623 (0.5); 1.6106 (16.0); 1.3726 (0.4); 1.3266 (1.4); 1.3026 (5.0); 1.2993 (4.8); 1.2912 (4.4); 1.2816 (3.6); 1.2750 (3.1); 1.2585 (1.5); 1.2389 (0.4); 1.0669 (1.3); 1.0504 (3.7); 1.0445 (3.0); 1.0340 (2.8); 1.0274 (3.5); 1.0104 (0.9); 0.9399 (0.6); 0.9181 (1.7); 0.8946 (0.8); 0.0469 (0.6); 0.0361 (17.7); 0.0252 (0.7)
I-334:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.3003 (2.0); 9.2846 (4.1); 9.2691 (2.0); 8.2666 (6.3); 8.2624 (6.7); 8.0294 (16.0); 7.8070 (3.0); 7.8030 (3.2); 7.7860 (3.9); 7.7817 (4.1); 7.7647 (1.5); 7.7451 (4.6); 7.7254 (4.6); 7.7102 (5.6); 7.6907 (2.1); 7.6468 (7.1); 7.6253 (11.6); 7.5525 (3.6); 7.5329 (2.9); 4.2802 (1.8); 4.2641 (1.9); 4.2473 (4.0); 4.2314 (3.9); 4.2139 (2.1); 4.1982 (1.9); 3.4387 (0.3); 3.3988 (0.4); 3.3266 (755.1); 3.2641 (0.6); 2.9944 (1.6); 2.7108 (0.6); 2.6709 (2.0); 2.6665 (1.5); 2.5783 (0.4); 2.5412 (117.0); 2.5060 (221.3); 2.5017 (293.9); 2.4975 (233.2); 2.3671 (0.5); 2.3330 (1.3); 2.3284 (1.8); 2.3243 (1.4); -0.0001 (1.0)
I-335:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3238 (0.4); 7.9861 (1.3); 7.6202 (0.4); 7.5955 (1.7); 7.5834 (1.1); 7.5748 (3.7); 7.5527 (0.4); 7.5367 (0.4); 7.4796 (2.2); 7.4721 (7.0); 7.4636 (1.5); 7.4569 (0.8); 7.4492 (0.6); 7.4417 (0.8); 7.3977 (1.8); 7.3712 (2.1); 7.3052 (17.2); 7.1088 (1.9); 7.0903 (0.8); 7.0311 (1.0); 7.0039 (0.9); 5.3447 (1.9); 4.6763 (0.9); 4.6303 (1.9); 4.5837 (1.0); 4.0656 (3.7); 3.8353 (2.5); 3.7644 (16.0); 3.7476 (0.4); 3.7191 (1.5); 2.5302 (5.5); 2.5231 (3.3); 2.4922 (1.2); 2.3709 (9.7); 2.3269 (0.5); 2.0528 (11.0); 1.5969 (16.6); 1.2985 (0.4); 0.1138 (0.7); 0.0549 (0.5); 0.0440 (16.6); 0.0331 (0.6)
I-336:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5747 (0.4); 7.5483 (4.1); 7.5273 (5.0); 7.5238 (4.3); 7.5028 (2.5); 7.4966 (2.5); 7.4316 (2.2); 7.3774 (0.9); 7.3681 (1.5); 7.3609 (1.0); 7.3539 (0.6); 7.3468 (1.0); 7.3391 (0.6); 7.2981 (2.0); 7.2026 (1.5); 7.1960 (1.4); 7.1744 (1.3); 7.1678 (1.2); 6.9706 (0.6); 6.9495 (1.2); 6.9284 (0.6); 5.3293 (0.7); 4.4199 (1.0); 4.3985 (0.9); 4.3715 (2.1); 4.3501 (2.0); 4.3231 (1.0); 4.3017 (1.0); 2.7728 (3.0); 2.5541 (16.0); 2.2262 (15.8); 2.0615 (1.0); 1.9642 (0.5); 1.3062 (0.4); 1.2891 (0.5); 1.2825 (0.7); 0.1070 (2.6); 0.0323 (1.8)
I-337:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2551 (0.7); 9.2395 (1.4); 9.2239 (0.7); 7.9694 (7.6); 7.9530 (0.8); 7.3266 (2.1); 7.3066 (2.4); 7.2532 (0.6); 7.2489 (0.5); 7.2322 (1.5); 7.2282 (1.4); 7.2113 (1.1); 7.2076 (1.2); 7.1784 (0.9); 7.1747 (1.0); 7.1567 (1.4); 7.1383 (0.6); 7.1351 (0.5); 7.0708 (2.4); 6.9499 (1.3); 6.9376 (1.1); 6.9335 (1.7); 6.9213 (1.2); 6.9178 (1.6); 6.9008 (0.8); 6.8972 (0.7); 4.1183 (0.7); 4.1026 (0.7); 4.0815 (1.6); 4.0656 (1.5); 4.0443 (0.8); 4.0286 (0.7); 3.9032 (16.0); 3.3357 (32.7); 2.8922 (5.0); 2.7342 (4.4); 2.5263 (0.4); 2.5127 (8.8); 2.5084 (17.2); 2.5039 (22.2); 2.4994 (16.0); 2.4950 (7.8); 2.4210 (6.4); 2.2131 (9.2); -0.0002 (0.8)
I-338:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6016 (1.4); 7.5817 (5.1); 7.5659 (0.4); 7.5622 (0.4); 7.5517 (2.3); 7.5344 (1.8); 7.5282 (1.8); 7.4798 (1.6); 7.4279 (0.8); 7.4179 (1.1); 7.4107 (0.9); 7.3974 (0.7); 7.3898 (0.4); 7.2994 (15.3); 7.2501 (1.2); 7.2434 (1.1); 7.2218 (1.0); 7.2151 (0.9); 6.4561 (0.4); 6.4349 (0.8); 6.4143 (0.4); 4.4815 (0.9); 4.4601 (0.9); 4.4331 (2.0); 4.4117 (1.9); 4.3847 (1.0); 4.3632 (1.0); 2.4207 (16.0); 2.0810 (0.8); 1.5852 (8.3); 1.2966 (0.6); 0.0497 (0.6); 0.0389 (15.9); 0.0297 (0.5); 0.0281 (0.6)
I-339:1 H-NMR(300.2 MHz, CDCl3): δ= 8.6897 (1.1); 7.6824 (1.8); 7.6644 (3.0); 7.6451 (1.8); 7.6102 (0.9); 7.5818 (9.1); 7.5766 (6.1); 7.5644 (14.7); 7.5400 (0.6); 7.5011 (8.5); 7.4722 (16.0); 7.4125 (20.2); 7.3839 (7.8); 7.3599 (0.9); 7.3462 (2.9); 7.3376 (2.8); 7.3322 (4.3); 7.3260 (3.8); 7.3165 (2.9); 7.3077 (2.2); 7.2988 (10.2); 5.0630 (0.9); 5.0557 (0.8); 5.0426 (1.9); 5.0364 (1.6); 5.0198 (3.7); 5.0084 (11.6); 5.0043 (11.9); 4.9893 (12.0); 4.9687 (3.6); 4.6636 (0.5); 4.6553 (0.5); 4.6351 (5.2); 4.6225 (9.9); 4.6157 (8.7); 4.5996 (4.3); 4.1990 (3.6); 4.1852 (1.5); 4.1786 (3.6); 4.1618 (2.6); 4.1511 (7.7); 4.1379 (3.4); 4.1307 (7.5); 4.1144 (1.3); 4.1032 (3.9); 4.0828 (3.8); 2.0757 (9.0); 1.6713 (11.2); 1.3153 (2.6); 1.2915 (6.7); 1.2677 (2.5); 0.9691 (0.4); 0.9152 (0.3); 0.1085 (0.4); 0.0354 (7.9); 0.0245 (0.3)
I-340:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.3071 (1.2); 9.2871 (1.2); 8.1954 (6.8); 7.9537 (1.1); 7.8053 (2.4); 7.7586 (2.1); 7.7442 (3.7); 7.7384 (3.0); 7.7235 (1.8); 7.7065 (1.9); 7.6871 (0.8); 7.6527 (1.3); 7.6332 (0.8); 7.6107 (2.0); 7.5883 (2.2); 7.5263 (1.4); 7.5221 (1.5); 7.5050 (1.2); 7.5008 (1.3); 7.2754 (2.1); 7.2692 (2.2); 7.1039 (1.5); 7.0976 (1.5); 7.0816 (1.4); 7.0753 (1.4); 5.2881 (0.7); 5.2699 (1.0); 5.2516 (0.7); 3.8490 (16.0); 3.3872 (27.9); 3.3768 (57.7); 2.8912 (7.3); 2.7336 (6.4); 2.5241 (0.4); 2.5156 (6.2); 2.5112 (13.2); 2.5066 (17.7); 2.5021 (12.7); 2.4976 (6.1); 1.5457 (5.0); 1.5283 (5.0)
I-341:1 H-NMR(300.1 MHz, CDCl3): δ= 10.5645 (0.6); 7.8033 (6.2); 7.4910 (0.4); 7.4684 (4.0); 7.4462 (1.7); 7.4198 (0.5); 7.3096 (1.9); 7.2834 (2.7); 7.2635 (4.9); 7.1684 (1.5); 7.1424 (1.1); 7.1172 (1.1); 7.1017 (0.7); 7.0946 (1.1); 7.0868 (0.7); 7.0583 (2.1); 6.9646 (3.1); 6.9615 (3.3); 6.8963 (3.2); 6.8931 (3.0); 6.5770 (2.3); 3.7639 (0.9); 3.7499 (1.6); 3.7365 (1.6); 3.7302 (1.4); 3.7238 (1.7); 3.7098 (1.0); 3.5305 (16.0); 2.9568 (1.2); 2.8848 (2.1); 2.8674 (2.0); 2.8473 (1.6); 2.1904 (12.0); 1.2538 (1.6); 0.0708 (0.4); -0.0009 (3.8)
I-342:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0106 (2.0); 7.4349 (2.4); 7.4140 (2.8); 7.3876 (3.0); 7.2636 (16.4); 7.1833 (1.8); 7.1786 (1.7); 7.1625 (1.5); 7.1577 (1.4); 7.0807 (0.3); 7.0697 (3.7); 7.0563 (2.9); 7.0514 (2.9); 7.0373 (0.5); 6.7906 (0.8); 6.7754 (1.2); 6.7669 (1.3); 6.7571 (0.8); 6.7503 (0.7); 6.5158 (0.6); 6.5017 (1.1); 6.4866 (0.6); 6.0501 (0.6); 6.0420 (0.6); 6.0342 (0.7); 6.0259 (0.6); 5.9343 (0.6); 5.9261 (0.6); 5.9181 (0.7); 5.9102 (0.6); 4.1768 (0.4); 4.1686 (0.4); 4.1606 (0.4); 4.1518 (0.6); 4.1426 (0.3); 4.1346 (0.3); 4.1141 (0.4); 4.1058 (0.4); 4.0978 (0.4); 4.0897 (0.4); 3.9626 (0.4); 3.9471 (0.7); 3.9313 (0.4); 3.9261 (0.3); 3.9102 (0.6); 3.9046 (0.5); 3.8892 (0.7); 3.8733 (0.4); 3.8677 (0.4); 3.8522 (0.5); 2.9570 (13.7); 2.8818 (12.7); 2.5953 (16.0); 2.5824 (1.1); 2.3167 (0.7); 2.3016 (15.9); 2.0886 (0.6); 2.0802 (0.7); 2.0676 (1.2); 2.0547 (0.8); 2.0463 (0.8); 2.0334 (0.4); 1.6002 (8.7); 1.0177 (0.7); 1.0058 (2.3); 1.0012 (2.4); 0.9899 (1.3); 0.9847 (2.4); 0.9800 (2.4); 0.9691 (1.0); 0.7707 (0.9); 0.7589 (2.9); 0.7554 (2.7); 0.7465 (2.6); 0.7424 (3.0); 0.7303 (0.9); -0.0002 (1.5)
I-343:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1323 (5.0); 7.8059 (0.6); 7.3416 (2.4); 7.3345 (2.6); 7.2984 (3.6); 7.2044 (2.0); 7.1771 (2.7); 7.1596 (0.5); 7.1563 (0.5); 7.1329 (1.3); 7.1299 (1.2); 7.1045 (1.4); 7.0914 (1.0); 7.0845 (1.2); 7.0682 (1.0); 7.0625 (1.2); 7.0578 (0.5); 7.0416 (2.2); 7.0347 (2.0); 7.0143 (1.2); 7.0072 (1.2); 6.8847 (0.6); 6.8781 (0.6); 6.8613 (1.0); 6.8587 (0.9); 6.8367 (0.6); 6.8311 (0.5); 4.1907 (0.4); 4.1669 (1.2); 4.1431 (1.2); 4.1193 (0.4); 3.8714 (1.0); 3.8496 (2.4); 3.8294 (2.4); 3.8072 (1.3); 3.8013 (1.2); 3.7929 (0.7); 3.7875 (0.9); 3.7791 (2.6); 3.7711 (1.0); 3.7655 (0.7); 3.7570 (1.1); 3.1283 (1.8); 3.1060 (3.5); 3.0837 (1.7); 2.7407 (16.0); 2.1494 (0.4); 2.1383 (0.5); 2.1210 (0.9); 2.1040 (0.5); 2.0928 (0.5); 2.0782 (5.6); 1.9079 (1.1); 1.8975 (1.1); 1.8859 (3.1); 1.8794 (0.8); 1.8743 (1.1); 1.8638 (1.0); 1.4662 (0.4); 1.3167 (1.5); 1.2929 (3.1); 1.2691 (1.5); 1.0909 (0.7); 1.0757 (1.7); 1.0689 (1.9); 1.0629 (1.0); 1.0541 (1.1); 1.0471 (1.8); 1.0404 (1.7); 1.0259 (0.9); 0.8340 (0.9); 0.8190 (2.0); 0.8127 (2.0); 0.8020 (1.8); 0.7964 (2.1); 0.7799 (0.7); 0.0341 (4.1)
I-344:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1164 (0.8); 9.1007 (1.7); 9.0849 (0.8); 7.7434 (0.7); 7.7237 (2.0); 7.7039 (1.8); 7.6902 (6.5); 7.6757 (2.2); 7.6562 (1.1); 7.6079 (2.7); 7.5445 (1.6); 7.5265 (4.0); 7.3669 (1.6); 7.3458 (3.8); 7.3161 (2.1); 7.2944 (0.9); 4.1497 (0.8); 4.1335 (0.8); 4.1130 (1.8); 4.0971 (1.7); 4.0764 (0.9); 4.0605 (0.8); 3.3313 (164.1); 2.6788 (0.5); 2.6001 (16.0); 2.5490 (30.9); 2.5141 (61.1); 2.5097 (81.1); 2.5055 (63.9); 2.4619 (7.7); 2.3368 (0.5)
I-345:1 H-NMR(499.9 MHz, CDCl3): δ= 14.9996 (0.9); 8.2820 (1.1); 7.6166 (5.6); 7.6064 (4.3); 7.5895 (0.4); 7.4498 (3.1); 7.4084 (1.1); 7.4034 (1.3); 7.3975 (1.6); 7.3939 (1.4); 7.3859 (0.8); 7.3173 (3.5); 7.3013 (3.9); 7.2586 (11.7); 7.0414 (3.8); 6.9548 (2.1); 6.9389 (1.9); 5.2972 (3.0); 4.2227 (1.3); 4.2109 (1.3); 4.1943 (2.8); 4.1825 (2.7); 4.1659 (1.4); 4.1541 (1.3); 2.4604 (10.7); 2.2827 (16.0); 2.0024 (4.5); 1.5422 (0.4); 1.2843 (0.5); 1.2556 (5.9); 0.8940 (0.5); 0.8803 (0.7); 0.8664 (0.4); 0.8594 (0.4); 0.8457 (0.5); 0.0062 (0.5); -0.0002 (11.7); -0.0068 (0.4)
I-346:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2820 (3.0); 9.2625 (3.1); 8.1867 (16.0); 7.9546 (1.2); 7.7604 (1.4); 7.7397 (5.1); 7.7315 (6.1); 7.7219 (4.8); 7.6951 (4.9); 7.6752 (2.2); 7.6476 (3.5); 7.6272 (2.4); 7.6102 (7.1); 7.4271 (6.2); 7.4228 (6.5); 7.4076 (8.2); 7.4032 (8.8); 7.2811 (5.0); 7.2619 (5.7); 7.2420 (3.2); 5.1686 (0.5); 5.1511 (2.1); 5.1329 (3.1); 5.1147 (2.1); 5.0972 (0.5); 3.3758 (48.3); 3.3703 (73.1); 3.3675 (80.8); 2.8927 (8.3); 2.7348 (7.2); 2.5159 (11.2); 2.5116 (23.4); 2.5071 (31.4); 2.5026 (22.7); 2.4983 (11.0); 1.4572 (15.2); 1.4397 (15.0); 1.2399 (0.6); -0.0002 (0.6)
I-347:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1798 (5.0); 7.7377 (0.6); 7.6215 (3.5); 7.6185 (3.0); 7.6096 (1.6); 7.6044 (2.3); 7.3941 (1.7); 7.3325 (0.7); 7.3234 (0.9); 7.3133 (1.2); 7.3069 (1.1); 7.2982 (10.5); 7.0275 (1.8); 7.0020 (2.1); 6.9244 (2.0); 6.7576 (1.1); 6.7330 (1.0); 3.8320 (1.0); 3.8098 (2.4); 3.7907 (2.4); 3.7684 (1.1); 2.9863 (1.8); 2.9639 (3.4); 2.9414 (1.6); 2.7486 (16.0); 2.3227 (11.7); 2.2053 (10.8); 1.5998 (9.4); 1.2950 (1.0); 0.1080 (0.7); 0.0487 (0.4); 0.0380 (9.8); 0.0271 (0.4)
I-348:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1156 (0.9); 9.0998 (1.9); 9.0842 (0.9); 7.7413 (0.8); 7.7213 (2.2); 7.7012 (2.2); 7.6932 (6.4); 7.6739 (2.5); 7.6544 (1.2); 7.6018 (3.0); 7.5432 (1.8); 7.5233 (1.4); 7.4375 (2.5); 7.4164 (2.9); 7.3835 (3.1); 7.1794 (1.7); 7.1589 (1.5); 4.1542 (0.9); 4.1381 (0.9); 4.1175 (1.9); 4.1017 (1.9); 4.0809 (1.0); 4.0652 (0.9); 3.3304 (125.4); 2.6781 (0.5); 2.5994 (16.0); 2.5485 (25.4); 2.5090 (74.2); 2.4667 (8.7); 2.3359 (0.5)
I-349:1 H-NMR(400.1 MHz, CDCl3): δ= 8.4208 (0.3); 8.0072 (2.6); 7.6410 (2.6); 7.6142 (2.6); 7.6021 (3.1); 7.5586 (0.4); 7.5431 (0.4); 7.5252 (0.4); 7.4766 (1.1); 7.4560 (4.9); 7.4485 (3.1); 7.4240 (1.0); 7.3819 (1.1); 7.2609 (13.7); 4.4157 (0.7); 4.4002 (0.8); 4.3796 (1.5); 4.3643 (1.5); 4.3434 (0.8); 4.3281 (0.8); 4.1208 (0.5); 2.9548 (16.0); 2.8782 (15.0); 1.5949 (0.6); -0.0002 (4.0)
I-350:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4001 (5.6); 8.3970 (5.7); 8.0318 (0.8); 8.0124 (1.2); 7.9957 (0.8); 7.7172 (0.5); 7.6907 (2.5); 7.6708 (6.8); 7.6680 (6.2); 7.6552 (0.7); 7.5910 (4.1); 7.5551 (3.1); 7.4925 (1.3); 7.4826 (2.0); 7.4750 (1.7); 7.4617 (1.5); 7.4542 (0.9); 7.4324 (0.7); 7.4270 (0.5); 7.4041 (4.9); 7.3957 (7.6); 7.3672 (0.8); 7.2995 (20.0); 6.1380 (0.9); 6.1274 (1.0); 6.1141 (1.0); 6.1035 (1.0); 5.9824 (0.9); 5.9718 (1.0); 5.9585 (1.0); 5.9479 (0.9); 5.2358 (0.4); 5.2145 (1.3); 5.1941 (1.6); 5.1750 (1.4); 5.1538 (0.5); 4.3800 (0.4); 4.3695 (0.4); 4.3576 (0.4); 4.3468 (0.4); 4.3313 (0.5); 4.3205 (0.5); 4.3085 (0.5); 4.2981 (0.5); 4.2891 (0.4); 4.2783 (0.4); 4.2666 (0.5); 4.2555 (0.4); 4.2403 (0.5); 4.2293 (0.5); 4.2178 (0.5); 4.2070 (0.5); 4.1954 (0.5); 4.1716 (1.4); 4.1478 (1.5); 4.1241 (0.5); 3.9071 (0.5); 3.8901 (0.6); 3.8832 (0.6); 3.8661 (0.6); 3.8582 (0.5); 3.8365 (0.9); 3.8190 (0.9); 3.7962 (0.6); 3.7887 (0.5); 3.7715 (0.5); 3.7645 (0.5); 3.7476 (0.4); 3.3632 (2.2); 3.3463 (2.2); 3.3365 (2.1); 3.3198 (2.0); 2.0831 (6.5); 1.6523 (13.7); 1.6303 (13.6); 1.5954 (16.0); 1.3213 (1.7); 1.2975 (3.5); 1.2738 (1.7); 0.0493 (0.7); 0.0383 (19.0); 0.0279 (0.7)
I-351:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7887 (2.4); 8.6944 (1.6); 8.6782 (1.6); 7.6311 (0.8); 7.6070 (2.4); 7.6022 (1.5); 7.5962 (1.6); 7.5866 (0.7); 7.5676 (2.3); 7.5364 (1.2); 7.5299 (1.4); 7.5094 (0.6); 7.5014 (0.9); 7.4940 (0.6); 7.4791 (0.6); 7.3419 (1.4); 7.3256 (1.4); 7.2986 (18.5); 7.2367 (0.8); 7.2302 (0.8); 7.2084 (0.7); 7.2016 (0.6); 6.5389 (0.3); 6.5178 (0.5); 4.5217 (0.4); 4.5001 (0.4); 4.4733 (0.8); 4.4519 (0.7); 4.4248 (0.4); 4.4034 (0.4); 2.4323 (1.0); 2.2277 (9.3); 2.0813 (0.5); 1.6033 (16.0); 1.3199 (0.3); 1.2919 (1.4); 0.1067 (0.6); 0.0479 (0.7); 0.0371 (16.5); 0.0261 (0.7)
I-352:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1427 (2.9); 9.1227 (2.9); 8.1487 (16.0); 7.9528 (1.7); 7.7589 (1.3); 7.7394 (4.1); 7.7202 (8.9); 7.6970 (4.9); 7.6774 (2.0); 7.6397 (3.4); 7.6350 (2.2); 7.6195 (2.1); 7.0838 (2.9); 7.0641 (4.6); 7.0558 (6.4); 6.9541 (4.9); 6.9346 (3.8); 5.0818 (0.5); 5.0644 (1.8); 5.0461 (2.6); 5.0277 (1.8); 5.0101 (0.4); 3.3616 (53.7); 3.3536 (68.9); 3.3515 (70.2); 2.8911 (11.9); 2.7324 (10.2); 2.6731 (0.4); 2.6684 (0.4); 2.6487 (2.7); 2.6351 (5.3); 2.6201 (2.9); 2.5905 (0.4); 2.5736 (0.7); 2.5464 (1.2); 2.5315 (2.7); 2.5130 (16.8); 2.5086 (33.6); 2.5041 (44.7); 2.4996 (32.2); 2.4952 (16.0); 2.4627 (0.7); 1.6974 (0.7); 1.6601 (7.0); 1.6523 (5.8); 1.6446 (6.9); 1.6339 (2.9); 1.6146 (1.1); 1.6015 (0.5); 1.4221 (13.5); 1.4046 (13.4); 1.2398 (0.7); -0.0003 (1.0)
I-353:1 H-NMR(499.9 MHz, CDCl3): δ= 8.1232 (1.0); 7.8580 (3.7); 7.6879 (1.9); 7.5454 (2.1); 7.5088 (5.9); 7.4587 (3.8); 7.3838 (2.7); 7.3210 (0.8); 7.2610 (1.6); 7.0636 (2.2); 7.0491 (2.6); 6.9523 (4.2); 6.9107 (1.4); 6.8741 (2.4); 6.8604 (2.2); 6.7619 (1.1); 5.2896 (6.9); 4.5313 (1.9); 4.1797 (7.3); 3.7342 (3.7); 3.7226 (3.9); 3.0792 (11.9); 2.9143 (5.0); 2.9020 (3.1); 2.8753 (1.6); 2.8041 (0.5); 2.6768 (3.3); 2.4158 (0.4); 2.2907 (13.3); 2.2549 (16.0); 2.2074 (4.1); 2.1752 (0.6); 2.1476 (1.6); 1.5990 (0.4); 1.4644 (0.3); 1.4189 (1.5); 1.2577 (6.3); 1.2227 (1.4); 1.2088 (1.5); 1.1108 (4.3); 0.9909 (0.6); 0.8793 (1.0); 0.8490 (1.2); -0.0002 (1.2)
I-354:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1902 (0.9); 9.1746 (1.8); 9.1586 (0.9); 8.2741 (2.7); 8.2699 (3.0); 7.8313 (1.3); 7.8273 (1.4); 7.8102 (1.6); 7.8061 (1.8); 7.7476 (0.8); 7.7278 (2.1); 7.7080 (1.9); 7.6948 (6.5); 7.6822 (2.4); 7.6624 (1.1); 7.6408 (3.0); 7.6194 (2.4); 7.5737 (2.7); 7.5143 (1.5); 7.4941 (1.2); 4.2739 (0.8); 4.2581 (0.9); 4.2407 (1.8); 4.2247 (1.7); 4.2072 (0.9); 4.1910 (0.8); 3.3316 (147.5); 2.6835 (0.4); 2.6791 (0.5); 2.5903 (16.0); 2.5492 (43.0); 2.5143 (56.7); 2.5100 (76.7); 2.5058 (62.5); 2.3368 (0.5); 2.3325 (0.4)
I-355:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3007 (16.0); 8.0572 (0.7); 7.7011 (1.8); 7.6613 (1.1); 7.6397 (9.5); 7.6177 (4.3); 7.5830 (5.6); 7.5208 (2.8); 7.4948 (3.4); 7.4308 (2.5); 7.4047 (3.4); 7.3238 (5.4); 7.3043 (31.3); 7.2831 (5.2); 7.2763 (3.3); 7.2684 (1.6); 7.2570 (4.5); 7.2313 (1.8); 3.7898 (10.8); 3.7714 (10.8); 2.9996 (5.4); 2.9262 (4.8); 1.6063 (13.4); 1.2977 (2.0); 1.2757 (0.4); 1.1074 (2.3); 1.0845 (8.6); 1.0711 (8.0); 1.0361 (7.6); 1.0228 (8.5); 0.9996 (2.3); 0.9224 (0.6); 0.8980 (0.5); 0.1131 (1.2); 0.0534 (1.0); 0.0427 (30.1); 0.0318 (1.3)
I-356:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0479 (2.0); 9.0267 (2.0); 8.1839 (9.2); 7.7493 (0.7); 7.7293 (2.3); 7.7091 (2.3); 7.6824 (4.7); 7.6775 (4.0); 7.6334 (2.0); 7.6129 (1.4); 7.2155 (2.8); 7.1959 (3.1); 6.9178 (3.8); 6.8956 (2.1); 6.8754 (1.8); 5.1512 (0.5); 5.1359 (1.0); 5.1186 (1.2); 5.1010 (0.5); 3.3339 (237.6); 2.7239 (0.8); 2.7063 (2.1); 2.6910 (2.1); 2.6757 (1.3); 2.6475 (0.3); 2.5414 (31.2); 2.5064 (79.7); 2.5020 (104.2); 2.4976 (78.0); 2.3329 (0.5); 2.3286 (0.6); 2.2175 (16.0); 2.0184 (0.4); 2.0048 (0.6); 1.9951 (0.7); 1.9832 (0.9); 1.9744 (1.0); 1.9603 (0.6); 1.8822 (0.6); 1.8690 (0.7); 1.8572 (0.8); 1.8372 (0.7); 1.8031 (0.4); 1.7805 (0.9); 1.7622 (1.5); 1.7512 (1.8); 1.7368 (1.4); -0.0002 (3.0)
I-357:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0254 (1.9); 8.1689 (5.7); 7.9549 (0.6); 7.7710 (0.4); 7.7513 (1.3); 7.7306 (2.1); 7.7277 (2.0); 7.7004 (1.4); 7.6808 (0.7); 7.6545 (1.0); 7.6350 (0.7); 7.4945 (0.3); 7.4875 (3.1); 7.4826 (1.1); 7.4709 (1.2); 7.4658 (4.1); 7.4590 (0.6); 7.3243 (0.5); 7.3174 (4.3); 7.3124 (1.3); 7.3007 (1.0); 7.2957 (3.4); 7.2888 (0.4); 3.3619 (11.3); 3.3566 (12.9); 3.3523 (15.6); 3.3493 (17.8); 2.8923 (4.1); 2.7340 (3.5); 2.5149 (4.1); 2.5104 (8.6); 2.5059 (11.6); 2.5013 (8.3); 2.4968 (4.0); 1.6340 (16.0)
I-358:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0258 (2.5); 7.9615 (2.6); 7.8359 (0.7); 7.7811 (5.9); 7.7757 (5.5); 7.7726 (5.3); 7.7598 (5.4); 7.6990 (0.5); 7.6772 (0.5); 7.6420 (0.8); 7.5954 (4.8); 7.5491 (2.0); 7.5321 (4.2); 7.5277 (4.2); 7.5054 (4.0); 7.5002 (3.9); 7.4760 (3.6); 7.4548 (3.1); 7.4339 (1.5); 7.4232 (1.8); 7.3536 (0.4); 7.3229 (0.4); 7.2876 (3.1); 7.2829 (3.0); 7.1527 (1.5); 7.1478 (1.5); 6.0541 (1.6); 5.9377 (1.6); 3.9390 (0.4); 3.9333 (0.4); 3.9021 (1.3); 3.8791 (1.7); 3.8663 (1.8); 3.8518 (1.6); 3.8294 (1.6); 3.8197 (1.4); 3.7753 (0.6); 3.5700 (0.4); 3.3235 (129.7); 3.3184 (117.2); 3.3148 (101.9); 2.9644 (0.4); 2.9044 (10.5); 2.8991 (9.7); 2.7450 (9.9); 2.7398 (9.4); 2.6075 (15.8); 2.6025 (16.0); 2.5143 (21.8); 2.5101 (24.1); 2.4696 (2.1); 2.4643 (2.0); 1.2466 (0.4)
I-359:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0888 (1.5); 9.0733 (3.0); 9.0595 (1.5); 8.0788 (13.2); 7.7631 (1.1); 7.7429 (9.1); 7.7241 (3.4); 7.7054 (4.2); 7.6851 (6.4); 7.6033 (2.9); 7.5830 (2.3); 7.4956 (0.5); 7.4754 (15.5); 7.4504 (0.5); 6.0456 (1.0); 6.0326 (1.9); 6.0207 (1.0); 5.9307 (1.0); 5.9176 (2.0); 5.9053 (1.1); 4.0382 (0.5); 4.0206 (0.5); 3.8977 (1.7); 3.8825 (2.6); 3.8727 (1.3); 3.8674 (1.3); 3.8397 (1.9); 3.8253 (2.9); 3.8119 (1.4); 3.3191 (58.1); 2.6710 (0.9); 2.5062 (111.2); 2.5019 (140.9); 2.4976 (103.0); 2.3287 (0.8); 1.9887 (2.0); 1.3978 (16.0); 1.1929 (0.5); 1.1751 (1.1); 1.1571 (0.5); -0.0002 (4.0)
I-360:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1717 (1.7); 9.1561 (3.6); 9.1405 (1.8); 7.9987 (16.0); 7.7684 (1.4); 7.7486 (4.2); 7.7290 (4.2); 7.7127 (5.2); 7.6933 (2.1); 7.6486 (5.8); 7.5745 (3.3); 7.5549 (2.6); 7.4240 (5.4); 7.4034 (5.9); 7.2531 (6.8); 6.8610 (3.4); 6.8427 (3.2); 4.2714 (1.6); 4.2558 (1.7); 4.2362 (3.6); 4.2205 (3.5); 4.2009 (1.9); 4.1853 (1.7); 3.3386 (136.8); 3.3345 (144.4); 2.6771 (0.4); 2.6723 (0.6); 2.5425 (57.5); 2.5077 (77.0); 2.5033 (99.3); 2.4990 (72.4); 2.3301 (0.6); 2.3256 (0.4); 2.1662 (0.6); 1.9071 (0.7); 1.8943 (1.4); 1.8856 (1.6); 1.8735 (2.8); 1.8612 (1.8); 1.8527 (1.6); 1.8404 (0.8); 0.9825 (1.7); 0.9713 (5.0); 0.9658 (5.4); 0.9504 (5.1); 0.9451 (5.0); 0.9344 (1.8); 0.6488 (1.8); 0.6375 (6.0); 0.6330 (5.6); 0.6256 (5.5); 0.6207 (6.0); 0.6092 (1.6); -0.0002 (2.4)
I-361:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5289 (0.4); 7.5131 (2.0); 7.5002 (5.2); 7.4217 (2.6); 7.3765 (1.0); 7.3713 (1.5); 7.3668 (1.2); 7.3583 (1.3); 7.3502 (2.6); 7.3422 (0.5); 7.3341 (2.6); 7.2587 (3.2); 7.0429 (3.1); 6.9537 (1.6); 6.9378 (1.4); 6.4372 (0.7); 6.4252 (1.3); 6.4133 (0.7); 4.2185 (1.0); 4.2060 (1.0); 4.1891 (2.2); 4.1767 (2.2); 4.1597 (1.2); 4.1473 (1.1); 3.2734 (0.3); 3.2592 (0.8); 3.2450 (1.1); 3.2308 (0.8); 3.2167 (0.4); 2.9212 (0.6); 2.8140 (0.5); 2.4790 (8.6); 2.3099 (0.4); 2.2855 (11.3); 1.9871 (1.4); 1.5840 (0.8); 1.4001 (16.0); 1.3859 (16.0); 1.3435 (0.6); 1.3297 (0.6); 1.2970 (1.1); 1.1308 (0.5); 1.1176 (0.5); -0.0002 (3.3)
I-362:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2942 (9.2); 8.2901 (16.0); 8.1185 (2.6); 7.5844 (9.1); 7.5807 (6.8); 7.4255 (3.1); 7.3991 (6.8); 7.3669 (24.0); 7.3636 (16.4); 7.3014 (12.6); 7.2973 (22.6); 7.0968 (4.8); 7.0709 (4.0); 7.0190 (3.8); 7.0157 (4.1); 7.0112 (4.0); 6.9921 (3.2); 6.9888 (3.5); 6.9844 (3.6); 6.9458 (7.0); 6.9403 (6.8); 6.1188 (1.7); 6.1080 (1.8); 6.0959 (1.9); 6.0852 (1.6); 5.9639 (1.7); 5.9531 (1.8); 5.9410 (1.9); 5.9304 (1.6); 5.3402 (1.4); 5.3360 (2.5); 4.3336 (0.8); 4.3226 (0.9); 4.3113 (0.8); 4.3003 (0.8); 4.2847 (1.1); 4.2737 (1.1); 4.2627 (1.0); 4.2515 (1.4); 4.2353 (0.8); 4.2242 (0.9); 4.2134 (0.8); 4.1974 (1.1); 4.1868 (1.0); 4.1754 (1.0); 4.1647 (0.9); 3.9017 (0.9); 3.8843 (1.4); 3.8790 (1.0); 3.8612 (1.1); 3.8532 (0.9); 3.8296 (1.7); 3.8116 (1.9); 3.7884 (1.1); 3.7797 (0.9); 3.7623 (1.1); 3.7396 (0.7); 2.0278 (0.7); 2.0108 (1.6); 1.9994 (2.0); 1.9831 (3.1); 1.9706 (1.9); 1.9662 (1.8); 1.9553 (1.7); 1.9382 (0.9); 1.5887 (15.1); 1.2953 (0.7); 1.0897 (2.0); 1.0744 (6.9); 1.0677 (6.6); 1.0522 (5.1); 1.0458 (7.0); 1.0402 (5.2); 1.0246 (2.4); 1.0023 (0.4); 0.9749 (0.3); 0.8029 (2.6); 0.7875 (8.7); 0.7814 (6.1); 0.7708 (7.8); 0.7656 (6.8); 0.7490 (1.9); 0.1072 (0.6); 0.0410 (13.0); 0.0368 (23.5); 0.0259 (1.0)
I-363:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3803 (8.8); 8.0229 (0.7); 8.0049 (1.2); 7.9842 (0.7); 7.7092 (0.3); 7.6831 (2.7); 7.6776 (2.3); 7.6725 (2.3); 7.6651 (6.1); 7.6618 (6.0); 7.6504 (0.5); 7.6453 (0.5); 7.5284 (4.8); 7.4991 (6.4); 7.4773 (1.3); 7.4650 (1.8); 7.4582 (1.7); 7.4465 (1.7); 7.4345 (6.3); 7.4052 (3.2); 7.2992 (20.7); 5.2409 (0.5); 5.2187 (1.5); 5.2015 (1.6); 5.1969 (1.7); 5.1797 (1.6); 5.1579 (0.5); 4.2899 (1.7); 4.2697 (1.6); 4.2423 (3.6); 4.2221 (3.4); 4.1947 (1.8); 4.1745 (1.7); 3.2981 (4.4); 3.2812 (4.3); 1.6547 (13.5); 1.6327 (13.4); 1.6150 (0.3); 1.5925 (16.0); 1.3068 (0.9); 0.9205 (1.0); 0.8975 (0.4); 0.0491 (0.8); 0.0384 (21.7); 0.0275 (0.8)
I-364:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1727 (0.9); 9.1530 (0.9); 8.1757 (3.4); 8.1746 (3.8); 8.1712 (2.3); 7.9541 (0.6); 7.7535 (0.5); 7.7340 (1.6); 7.7145 (1.6); 7.7015 (2.2); 7.6912 (2.1); 7.6712 (0.8); 7.6302 (1.3); 7.6105 (0.8); 7.2669 (1.0); 7.2622 (1.2); 7.2353 (1.0); 7.2304 (1.3); 7.1717 (0.8); 7.1499 (1.3); 7.1471 (1.3); 7.0876 (1.4); 7.0657 (2.1); 7.0442 (1.0); 5.1023 (0.7); 5.0839 (1.0); 5.0660 (0.7); 3.7905 (16.0); 3.3893 (14.1); 3.3830 (11.8); 3.3787 (11.4); 3.3730 (13.5); 3.3602 (14.5); 2.8928 (3.9); 2.7341 (3.4); 2.5157 (5.0); 2.5113 (10.7); 2.5067 (14.4); 2.5022 (10.4); 2.4977 (5.0); 1.4360 (5.2); 1.4186 (5.2)
I-365:1 H-NMR(300.2 MHz, CDCl3): δ= 9.4984 (0.6); 8.3632 (5.0); 7.6049 (0.6); 7.5791 (1.6); 7.5530 (1.2); 7.4905 (1.5); 7.4649 (0.8); 7.3639 (1.9); 7.3540 (2.6); 7.3459 (1.4); 7.3270 (2.4); 7.2982 (6.0); 7.0658 (2.1); 6.9353 (1.1); 6.9015 (1.5); 6.7132 (2.2); 6.5255 (1.1); 4.7050 (1.1); 4.6880 (1.0); 4.6568 (2.2); 4.6397 (2.1); 4.6086 (1.1); 4.5915 (1.1); 2.7861 (0.5); 2.7544 (16.0); 2.5430 (0.4); 2.5093 (3.5); 2.5026 (6.1); 2.4953 (3.4); 2.4057 (0.4); 2.3111 (8.2); 1.6010 (1.2); 1.2959 (0.4); 0.0389 (6.2)
I-366:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1265 (1.0); 9.1122 (2.0); 9.0974 (1.0); 8.1058 (11.0); 7.7607 (0.7); 7.7410 (2.2); 7.7209 (2.4); 7.7015 (6.6); 7.6850 (1.4); 7.6191 (2.2); 7.6002 (1.5); 7.4064 (3.1); 7.3856 (3.8); 7.3079 (0.3); 7.2795 (3.3); 7.2157 (2.0); 7.2113 (1.8); 7.1950 (1.7); 7.1900 (1.6); 5.9610 (0.7); 5.9525 (0.8); 5.9431 (0.8); 5.9339 (0.7); 5.8443 (0.7); 5.8350 (0.8); 5.8254 (0.9); 5.8178 (0.7); 5.7561 (4.2); 3.8398 (0.3); 3.8335 (0.3); 3.8253 (0.3); 3.8120 (0.5); 3.8034 (0.6); 3.7973 (0.6); 3.7884 (0.5); 3.7425 (0.9); 3.7270 (1.2); 3.7190 (0.7); 3.7105 (0.7); 3.6934 (0.8); 3.6783 (0.8); 3.6603 (0.6); 3.6416 (0.3); 3.3191 (42.0); 2.6748 (0.9); 2.6704 (1.2); 2.6659 (0.9); 2.5235 (3.6); 2.5101 (83.0); 2.5059 (167.7); 2.5014 (220.5); 2.4969 (159.0); 2.4926 (77.4); 2.3499 (16.0); 2.3330 (1.2); 2.3280 (1.4); 2.3235 (1.1); 2.2921 (0.3); 1.9884 (0.5); 1.2350 (1.0); 1.1749 (0.5); 1.1634 (0.3); 0.8804 (0.6); 0.1463 (0.5); 0.0079 (4.9); -0.0002 (117.4); -0.0084 (5.2); -0.1497 (0.5)
I-367:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.0714 (1.6); 9.0595 (3.3); 9.0477 (1.6); 8.0203 (16.0); 7.6482 (4.9); 7.6469 (4.8); 7.5612 (5.5); 7.5444 (6.6); 7.3695 (3.6); 7.3654 (3.6); 7.3525 (6.0); 7.3486 (3.3); 7.3365 (6.4); 7.3208 (3.7); 7.0232 (3.4); 7.0075 (3.2); 6.9949 (2.5); 6.9939 (2.5); 6.9905 (3.0); 6.9789 (2.2); 6.9779 (2.2); 6.9744 (2.8); 6.9379 (4.1); 6.9341 (5.8); 6.9303 (3.3); 6.0402 (1.1); 6.0295 (1.8); 6.0200 (1.1); 5.9479 (1.1); 5.9374 (2.0); 5.9277 (1.1); 3.8773 (1.5); 3.8648 (2.4); 3.8588 (1.3); 3.8526 (1.2); 3.8312 (2.0); 3.8193 (2.9); 3.8109 (1.3); 3.8072 (1.2); 3.3240 (13.9); 3.0802 (1.5); 2.5130 (1.4); 2.5095 (3.1); 2.5060 (4.2); 2.5024 (3.1); 2.4990 (1.4); 1.9932 (0.6); 1.9831 (1.4); 1.9764 (1.5); 1.9664 (2.8); 1.9564 (1.6); 1.9497 (1.5); 1.9395 (0.8); 1.1090 (4.5); 0.9999 (1.7); 0.9912 (4.9); 0.9868 (5.2); 0.9835 (2.4); 0.9785 (2.4); 0.9745 (5.0); 0.9701 (5.0); 0.9619 (1.9); 0.7073 (1.9); 0.6987 (5.5); 0.6947 (5.5); 0.6889 (5.3); 0.6848 (5.8); 0.6759 (1.7)
I-368:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1447 (2.1); 8.1982 (4.8); 7.9540 (1.0); 7.7722 (0.5); 7.7549 (3.1); 7.7346 (6.2); 7.7026 (1.5); 7.6830 (0.8); 7.6699 (4.1); 7.6532 (1.9); 7.6486 (3.1); 7.6358 (0.8); 3.3606 (18.1); 3.3557 (21.4); 3.3493 (23.7); 2.8925 (6.6); 2.7333 (5.9); 2.5144 (6.1); 2.5100 (12.9); 2.5055 (17.5); 2.5009 (12.6); 2.4964 (6.0); 1.6458 (16.0)
I-369:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5863 (2.6); 7.5826 (2.7); 7.5511 (0.6); 7.5291 (1.1); 7.5064 (0.7); 7.4746 (0.5); 7.4501 (1.2); 7.4474 (1.1); 7.4257 (0.8); 7.4230 (0.8); 7.3939 (7.3); 7.3905 (7.0); 7.3578 (1.2); 7.3310 (1.5); 7.2985 (11.9); 7.0980 (1.1); 6.9154 (2.3); 6.7327 (1.2); 6.4507 (0.4); 6.4322 (0.8); 6.4113 (0.4); 6.0940 (0.6); 6.0833 (0.7); 6.0714 (0.7); 6.0607 (0.6); 5.9391 (0.6); 5.9283 (0.7); 5.9164 (0.7); 5.9057 (0.6); 4.2293 (0.4); 4.2185 (0.4); 4.2075 (0.4); 4.1965 (0.4); 4.1914 (0.4); 4.1422 (0.4); 4.1315 (0.4); 4.1204 (0.4); 4.1095 (0.4); 3.9994 (0.4); 3.9796 (0.5); 3.9573 (0.4); 3.9275 (0.5); 3.9247 (0.5); 3.9049 (0.6); 3.8823 (0.4); 3.8755 (0.3); 3.8559 (0.4); 2.6379 (15.9); 2.6222 (1.1); 2.3421 (16.0); 1.6287 (1.2); 0.1073 (0.7); 0.0481 (0.5); 0.0374 (13.7); 0.0264 (0.5)
I-370:1 H-NMR(300.2 MHz, CDCl3): δ= 9.7425 (0.6); 8.4040 (5.1); 7.3710 (1.2); 7.3522 (1.9); 7.3447 (2.7); 7.3256 (2.2); 7.3184 (1.7); 7.2981 (6.5); 7.0619 (2.0); 7.0390 (1.4); 7.0129 (1.2); 6.9945 (1.0); 6.9916 (1.0); 6.9865 (1.2); 6.9837 (1.0); 6.9676 (0.9); 6.9646 (0.8); 6.9597 (1.1); 6.9569 (0.9); 6.9208 (1.1); 6.9037 (1.8); 6.8974 (2.9); 6.8913 (2.0); 4.6992 (1.0); 4.6821 (1.0); 4.6511 (2.2); 4.6340 (2.1); 4.6029 (1.1); 4.5858 (1.1); 2.7461 (16.0); 2.5096 (3.3); 2.5029 (6.0); 2.4954 (3.3); 2.3209 (8.0); 1.9814 (0.5); 1.9701 (0.6); 1.9535 (1.1); 1.9367 (0.6); 1.9255 (0.6); 1.5998 (2.3); 1.3059 (0.7); 1.2992 (0.7); 1.0596 (0.7); 1.0445 (1.9); 1.0375 (2.0); 1.0226 (1.1); 1.0161 (2.0); 1.0096 (1.8); 0.9947 (0.9); 0.9213 (0.7); 0.7820 (0.9); 0.7667 (2.3); 0.7611 (2.0); 0.7504 (1.9); 0.7446 (2.5); 0.7281 (0.7); 0.0393 (6.9)
I-371:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1138 (0.9); 9.0982 (2.0); 9.0823 (1.0); 7.8576 (3.4); 7.8539 (3.6); 7.7456 (0.8); 7.7259 (2.4); 7.7060 (2.0); 7.6735 (8.5); 7.6555 (1.4); 7.5912 (3.0); 7.5291 (1.7); 7.5092 (1.5); 7.4964 (2.3); 7.4751 (3.6); 7.4119 (2.2); 7.4079 (2.2); 7.3909 (1.4); 7.3867 (1.4); 4.2936 (0.8); 4.2778 (0.9); 4.2590 (1.8); 4.2433 (1.8); 4.2245 (1.0); 4.2087 (0.9); 3.3521 (13.5); 2.5898 (16.0); 2.5487 (17.8); 2.5134 (6.0); 2.5093 (7.6); 2.5053 (5.6); -0.0002 (0.6)
I-372:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1267 (1.0); 9.1122 (2.0); 9.0982 (1.0); 8.1030 (9.8); 7.7616 (0.7); 7.7426 (2.1); 7.7223 (2.2); 7.7044 (6.6); 7.6851 (1.3); 7.6194 (2.1); 7.5999 (1.4); 7.4220 (3.7); 7.3566 (0.4); 7.3319 (9.5); 7.3114 (0.6); 5.9478 (0.7); 5.9395 (0.8); 5.9299 (0.8); 5.9216 (0.7); 5.8303 (0.7); 5.8218 (0.8); 5.8126 (0.9); 5.8035 (0.8); 5.7561 (8.4); 3.8381 (0.3); 3.8104 (0.5); 3.8016 (0.6); 3.7965 (0.5); 3.7870 (0.5); 3.7390 (0.9); 3.7309 (0.7); 3.7243 (1.0); 3.7032 (0.6); 3.6863 (0.8); 3.6702 (0.8); 3.6530 (0.6); 3.6337 (0.3); 3.3187 (27.1); 2.6751 (0.7); 2.6703 (1.0); 2.6660 (0.7); 2.5098 (64.0); 2.5057 (125.1); 2.5013 (162.4); 2.4969 (117.7); 2.4927 (58.5); 2.3460 (16.0); 2.3331 (1.2); 2.3285 (1.2); 2.3236 (0.9); 2.2893 (0.3); 1.9886 (0.5); 1.2352 (0.7); 1.1746 (0.4); 0.1458 (0.4); 0.0074 (4.0); -0.0002 (82.2); -0.0084 (4.1); -0.1499 (0.4)
I-373:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1546 (1.7); 9.1344 (1.7); 8.1477 (9.3); 7.9522 (0.4); 7.7600 (0.7); 7.7403 (2.4); 7.7205 (5.2); 7.6977 (2.8); 7.6783 (1.2); 7.6401 (1.9); 7.6199 (1.2); 7.1429 (3.4); 7.1021 (1.3); 7.0825 (2.2); 7.0789 (2.2); 7.0387 (3.5); 7.0193 (1.9); 5.0760 (1.0); 5.0577 (1.5); 5.0392 (1.1); 3.3825 (99.9); 3.3797 (102.7); 2.8917 (2.4); 2.7330 (2.1); 2.5280 (0.4); 2.5146 (9.5); 2.5103 (20.3); 2.5058 (27.5); 2.5013 (20.0); 2.4969 (9.7); 2.1437 (15.3); 2.0683 (16.0); 1.4277 (8.1); 1.4102 (8.2)
I-374:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0410 (0.8); 9.0263 (1.6); 9.0117 (0.8); 7.9609 (1.6); 7.7779 (6.2); 7.7249 (0.4); 7.6431 (3.3); 7.6180 (1.2); 7.5973 (2.7); 7.5890 (2.0); 7.5770 (3.9); 7.5559 (3.2); 7.5213 (0.7); 7.4719 (1.5); 7.4517 (2.1); 7.4315 (1.0); 7.4224 (2.2); 7.4173 (3.1); 7.4016 (1.5); 7.3969 (1.5); 7.2814 (2.9); 7.1463 (1.5); 6.0795 (0.6); 6.0686 (0.9); 6.0537 (0.6); 5.9634 (0.6); 5.9529 (0.9); 5.9384 (0.6); 3.9214 (0.5); 3.9053 (0.9); 3.8864 (0.9); 3.8714 (0.9); 3.8617 (0.7); 3.8506 (1.0); 3.8354 (0.7); 3.8264 (0.7); 3.8145 (0.7); 3.8026 (0.5); 3.3178 (126.3); 2.8989 (9.4); 2.7400 (8.8); 2.6023 (16.0); 2.5132 (10.8); 2.5092 (14.0); 2.5054 (10.6); 2.4664 (1.7)
I-375:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0579 (0.8); 9.0422 (1.6); 9.0265 (0.7); 7.7333 (0.7); 7.7141 (2.1); 7.7055 (6.4); 7.6945 (1.7); 7.6681 (2.0); 7.6481 (1.0); 7.5918 (2.5); 7.5678 (3.3); 7.5464 (4.5); 7.5312 (1.5); 7.5109 (1.1); 7.4316 (4.2); 7.4103 (3.1); 4.1396 (0.8); 4.1239 (0.8); 4.1048 (1.8); 4.0890 (1.7); 4.0696 (0.9); 4.0542 (0.8); 3.3593 (0.4); 3.3181 (309.4); 2.6743 (1.4); 2.6699 (1.9); 2.6656 (1.4); 2.5898 (16.0); 2.5403 (38.0); 2.5052 (215.9); 2.5008 (288.4); 2.4963 (223.4); 2.3319 (1.4); 2.3275 (1.9); 2.3231 (1.4); -0.0002 (1.0)
I-376:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3265 (0.8); 8.2843 (0.4); 8.2723 (16.0); 7.6870 (8.7); 7.6696 (9.8); 7.6413 (0.9); 7.6380 (0.8); 7.5755 (0.4); 7.4822 (7.4); 7.4756 (7.5); 7.4451 (4.4); 7.3574 (0.4); 7.3441 (1.7); 7.3352 (1.8); 7.3284 (2.6); 7.3220 (2.4); 7.3136 (1.7); 7.3016 (3.8); 7.1443 (5.7); 7.1171 (8.6); 7.0205 (5.0); 7.0139 (4.9); 6.9932 (3.3); 6.9866 (3.2); 5.3313 (13.2); 3.9082 (0.4); 3.8134 (0.4); 3.7950 (0.4); 3.7371 (8.9); 3.7185 (8.7); 2.1987 (2.7); 1.7006 (2.9); 1.3349 (0.3); 1.3120 (0.3); 1.2918 (0.7); 1.1323 (2.5); 1.1154 (6.8); 1.1107 (8.0); 1.0945 (3.8); 1.0449 (0.6); 1.0254 (0.5); 0.9756 (3.6); 0.9593 (7.9); 0.9379 (2.3); 0.1117 (2.8); 0.0344 (2.3)
I-377:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0357 (1.6); 9.0209 (3.1); 9.0069 (1.6); 8.7404 (0.3); 8.3158 (0.4); 8.1642 (0.4); 8.1178 (0.6); 8.0954 (14.6); 8.0838 (1.9); 7.7580 (1.3); 7.7388 (4.1); 7.7193 (4.4); 7.7025 (5.8); 7.6805 (6.8); 7.6098 (3.3); 7.5906 (2.8); 7.5012 (3.4); 7.4869 (4.4); 7.4806 (4.6); 7.4667 (3.7); 7.2854 (0.5); 7.2720 (0.7); 7.2653 (0.7); 7.2500 (0.6); 7.1697 (4.1); 7.1480 (7.5); 7.1260 (3.6); 6.9836 (0.6); 6.9609 (1.0); 6.9389 (0.5); 6.3056 (1.2); 6.2903 (1.1); 5.7864 (1.1); 5.7757 (1.5); 5.7686 (1.4); 5.7559 (16.0); 5.6677 (1.1); 5.6572 (1.4); 5.6501 (1.3); 5.6401 (1.1); 4.6063 (0.6); 4.5905 (0.8); 4.5738 (0.6); 4.4143 (0.3); 4.4020 (0.4); 4.3963 (0.4); 4.3844 (0.4); 4.0377 (0.7); 4.0202 (0.7); 3.8898 (0.4); 3.8741 (0.6); 3.8550 (1.1); 3.8383 (1.5); 3.8210 (1.5); 3.8074 (2.2); 3.7924 (2.2); 3.7743 (1.1); 3.7559 (1.1); 3.7409 (1.2); 3.7309 (0.9); 3.7197 (0.5); 3.7052 (0.8); 3.6917 (0.6); 3.6670 (0.5); 3.6562 (0.4); 3.6075 (0.5); 3.5945 (0.4); 3.5383 (0.7); 3.5189 (0.8); 3.5060 (0.7); 3.3199 (53.0); 2.8713 (0.5); 2.8445 (0.5); 2.8276 (1.0); 2.8101 (0.4); 2.6704 (1.8); 2.5057 (250.1); 2.5015 (317.2); 2.4972 (231.3); 2.3283 (1.8); 1.9886 (2.8); 1.4013 (4.4); 1.3843 (4.6); 1.3689 (1.0); 1.3501 (0.6); 1.3320 (1.2); 1.3139 (1.2); 1.2954 (0.8); 1.2753 (0.4); 1.2358 (3.4); 1.2063 (0.5); 1.1928 (1.0); 1.1748 (1.8); 1.1642 (0.9); 1.1572 (1.1); 1.1478 (1.4); 1.1299 (0.9); 0.9362 (0.6); 0.9198 (0.6); 0.8805 (3.5); 0.8539 (0.5); 0.1460 (0.6); -0.0002 (148.8); -0.0083 (8.0); -0.1497 (0.7)
I-378:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3683 (11.6); 8.0551 (2.0); 7.9230 (1.1); 7.8962 (1.2); 7.6522 (3.7); 7.6501 (3.7); 7.6451 (2.6); 7.6359 (6.7); 7.6328 (6.7); 7.5355 (3.3); 7.5024 (0.4); 7.4892 (1.4); 7.4750 (1.9); 7.4687 (1.7); 7.4593 (1.2); 7.4506 (0.8); 7.3035 (23.2); 6.6384 (8.6); 5.4209 (0.5); 5.4014 (1.2); 5.3779 (1.3); 2.9984 (16.0); 2.9246 (14.5); 2.6391 (1.6); 2.6223 (2.8); 2.3562 (0.4); 2.3179 (1.2); 2.3045 (0.9); 2.2906 (0.8); 2.2738 (0.9); 2.2568 (0.3); 1.9592 (1.1); 1.9362 (2.3); 1.9201 (4.4); 1.9075 (2.5); 1.9007 (2.5); 1.8838 (0.9); 1.8764 (0.8); 1.6153 (12.6); 1.2968 (1.9); 0.9231 (0.4); 0.8968 (0.4); 0.1117 (0.4); 0.0521 (0.7); 0.0413 (24.0); 0.0304 (0.8)
I-379:1 H-NMR(300.2 MHz, CDCl3): δ= 9.2839 (2.0); 8.5933 (2.3); 8.3855 (4.7); 8.1069 (0.9); 8.0937 (0.8); 8.0894 (0.9); 8.0809 (1.1); 8.0784 (1.1); 8.0648 (1.0); 7.9575 (0.4); 7.8170 (0.5); 7.8128 (0.5); 7.7939 (0.9); 7.7891 (1.0); 7.7845 (0.5); 7.7662 (0.7); 7.7613 (0.6); 7.7266 (0.8); 7.7229 (0.8); 7.6998 (1.0); 7.6963 (0.7); 7.6759 (0.4); 7.6732 (0.4); 7.5800 (2.3); 7.5716 (1.4); 7.5549 (0.9); 7.3208 (2.0); 7.3166 (1.9); 7.2984 (15.7); 5.3373 (0.6); 5.2045 (2.6); 5.1859 (2.6); 1.6114 (16.0); 0.0474 (0.4); 0.0366 (12.9); 0.0257 (0.4)
I-380:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1954 (5.0); 7.9872 (0.6); 7.9611 (0.6); 7.6099 (1.4); 7.5897 (4.0); 7.5866 (3.4); 7.5693 (0.3); 7.5192 (1.8); 7.4693 (0.8); 7.4594 (1.2); 7.4521 (0.9); 7.4468 (0.5); 7.4382 (0.8); 7.4309 (0.4); 7.2985 (1.6); 6.6189 (4.8); 5.3944 (0.6); 5.3703 (0.6); 2.7698 (16.0); 2.6109 (1.4); 2.6004 (1.3); 2.3021 (0.6); 2.2886 (0.5); 2.2759 (0.4); 2.2584 (0.4); 1.9513 (0.5); 1.9435 (0.5); 1.9270 (1.2); 1.9186 (1.2); 1.9088 (2.5); 1.8974 (1.4); 1.8890 (1.3); 1.7208 (0.4); 0.0334 (1.6)
I-381:1 H-NMR(300.2 MHz, CDCl3): δ= 9.4227 (1.9); 8.7129 (9.3); 8.7079 (6.1); 8.6980 (6.2); 8.6929 (9.8); 8.0875 (1.3); 8.0680 (2.4); 8.0486 (1.3); 7.6402 (0.7); 7.6138 (4.7); 7.6071 (3.9); 7.6024 (4.1); 7.5954 (11.0); 7.5923 (10.6); 7.5829 (1.4); 7.5685 (0.6); 7.5631 (0.7); 7.5421 (10.9); 7.5369 (6.9); 7.5273 (6.8); 7.5220 (10.7); 7.5031 (6.9); 7.4740 (16.0); 7.4281 (1.0); 7.4215 (0.9); 7.4123 (2.8); 7.3995 (12.2); 7.3826 (3.4); 7.3713 (6.7); 7.2983 (8.7); 5.3303 (0.9); 4.2366 (0.8); 4.2164 (2.6); 4.1963 (2.6); 4.1693 (5.7); 4.1492 (5.5); 4.1223 (2.9); 4.1022 (2.8); 2.2305 (0.4); 2.2174 (0.9); 2.2089 (1.5); 2.1957 (2.1); 2.1870 (2.1); 2.1743 (1.7); 2.1654 (1.0); 2.1522 (0.5); 1.2911 (2.2); 1.2681 (0.5); 0.9141 (0.3); 0.8898 (0.4); 0.4741 (0.6); 0.4599 (0.9); 0.4461 (4.2); 0.4379 (6.5); 0.4337 (7.3); 0.4184 (5.6); 0.4114 (5.0); 0.4038 (4.5); 0.3959 (4.1); 0.3914 (3.7); 0.3876 (3.7); 0.3808 (4.1); 0.3547 (0.8); 0.1072 (1.3); 0.0338 (8.7); 0.0229 (0.4)
I-382:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0755 (0.6); 9.0608 (1.3); 9.0461 (0.7); 8.0271 (6.2); 7.6517 (2.3); 7.5715 (2.1); 7.5505 (2.6); 7.4030 (1.2); 7.3867 (1.8); 7.3824 (4.0); 7.3657 (1.5); 7.3618 (2.6); 6.9027 (1.1); 6.8977 (1.3); 6.8827 (1.0); 6.8771 (1.3); 6.8345 (1.4); 6.8291 (2.7); 6.8234 (1.9); 6.8158 (1.7); 6.8112 (1.1); 6.7961 (1.4); 6.7910 (1.1); 6.0555 (0.4); 6.0424 (0.8); 6.0302 (0.5); 5.9397 (0.4); 5.9271 (0.9); 5.9147 (0.5); 3.8897 (0.8); 3.8755 (1.3); 3.8610 (0.7); 3.8315 (0.9); 3.8174 (1.4); 3.8037 (0.9); 3.7792 (16.0); 3.3145 (64.4); 2.8995 (1.7); 2.7406 (1.5); 2.5139 (6.6); 2.5095 (9.1); 2.5052 (7.0)
I-383:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6320 (0.5); 7.6061 (2.5); 7.5851 (7.6); 7.5640 (0.7); 7.5231 (3.6); 7.5015 (0.5); 7.4954 (0.4); 7.4844 (1.6); 7.4751 (2.5); 7.4678 (1.6); 7.4613 (1.0); 7.4536 (1.5); 7.4460 (0.9); 7.4087 (3.3); 7.3821 (3.8); 7.2983 (24.9); 7.1897 (1.0); 7.1681 (1.6); 7.1468 (1.0); 7.0868 (3.8); 7.0306 (2.2); 7.0181 (1.2); 7.0040 (1.9); 5.3374 (1.0); 5.0467 (0.6); 4.4120 (0.4); 4.3878 (0.6); 4.3607 (0.6); 4.3363 (0.6); 4.3123 (0.4); 4.1946 (0.6); 4.1708 (1.6); 4.1470 (1.6); 4.1232 (1.0); 4.0958 (1.0); 4.0685 (1.2); 4.0446 (0.6); 3.9347 (0.3); 3.8893 (0.7); 3.8416 (0.6); 3.7981 (0.3); 3.7820 (0.4); 3.7622 (0.6); 3.7382 (1.3); 3.7142 (1.1); 3.6871 (0.4); 2.6536 (1.8); 2.6491 (1.8); 2.6265 (4.4); 2.5980 (3.8); 2.5157 (11.2); 2.4006 (1.0); 2.3761 (2.7); 2.3391 (16.0); 2.3099 (1.9); 2.0827 (7.0); 1.6174 (8.0); 1.4701 (11.4); 1.3207 (2.2); 1.2969 (5.0); 1.2731 (2.2); 1.2133 (0.5); 0.9175 (0.4); 0.8941 (0.4); 0.1196 (1.4); 0.1078 (26.6); 0.0956 (1.2); 0.0484 (1.0); 0.0377 (23.5); 0.0268 (1.0)
I-384:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.8832 (2.2); 8.1346 (4.9); 7.9528 (0.5); 7.7706 (0.5); 7.7510 (1.4); 7.7298 (1.9); 7.7237 (2.0); 7.6992 (1.6); 7.6801 (0.8); 7.6541 (1.1); 7.6351 (0.8); 7.3786 (3.0); 7.3567 (3.4); 6.8228 (0.4); 6.8151 (3.4); 6.7931 (3.2); 3.7091 (14.0); 3.3743 (42.1); 3.3726 (42.4); 3.3699 (41.9); 3.3685 (41.8); 2.8917 (3.2); 2.7335 (2.9); 2.5100 (10.1); 2.5057 (13.7); 2.5014 (10.3); 1.6328 (16.0)
I-385:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1242 (1.2); 9.1088 (2.5); 9.0932 (1.2); 7.9608 (1.6); 7.8204 (0.4); 7.7023 (8.8); 7.6019 (2.2); 7.5819 (3.6); 7.5612 (1.7); 7.4710 (2.3); 7.4512 (3.1); 7.4375 (1.1); 7.4315 (1.4); 7.4185 (1.9); 7.3810 (0.4); 7.3622 (0.4); 7.3299 (3.4); 7.3100 (3.8); 7.2834 (4.1); 7.1482 (2.5); 7.0762 (4.5); 6.9562 (2.4); 6.9356 (2.2); 4.1292 (1.2); 4.1136 (1.4); 4.0921 (2.8); 4.0763 (2.8); 4.0550 (1.5); 4.0392 (1.4); 3.3179 (171.4); 2.8989 (8.9); 2.7401 (8.3); 2.5954 (22.8); 2.5092 (18.1); 2.4629 (1.4); 2.4318 (11.6); 2.3948 (1.9); 2.3106 (1.6); 2.2733 (1.1); 2.2419 (0.3); 2.2119 (16.0); 2.1750 (0.9); 1.2456 (0.4)
I-386:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0996 (1.7); 9.0793 (1.8); 7.9595 (0.5); 7.7268 (0.6); 7.7073 (1.8); 7.6881 (1.9); 7.6738 (2.6); 7.6544 (1.0); 7.6306 (2.2); 7.6109 (2.3); 7.5365 (4.4); 7.5142 (1.4); 7.3972 (2.2); 7.3765 (2.6); 7.3147 (4.8); 7.1285 (1.2); 7.1094 (2.0); 7.0907 (1.2); 6.8596 (1.3); 6.8407 (2.1); 6.8222 (1.1); 5.4665 (0.9); 5.4487 (1.3); 5.4305 (0.9); 3.7196 (16.0); 3.3382 (96.5); 2.8973 (2.6); 2.7382 (2.4); 2.5088 (12.1); 2.3413 (15.2); 1.6151 (6.2); 1.5983 (6.2)
I-387:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2370 (1.7); 9.2213 (3.6); 9.2056 (1.7); 8.0366 (15.9); 7.7600 (1.3); 7.7405 (4.1); 7.7210 (4.7); 7.7102 (5.4); 7.6904 (1.8); 7.6563 (7.6); 7.6321 (9.0); 7.5796 (3.3); 7.5602 (2.5); 7.4055 (3.2); 7.3853 (2.7); 4.2234 (1.6); 4.2075 (1.7); 4.1872 (3.6); 4.1714 (3.5); 4.1510 (1.8); 4.1352 (1.7); 3.3294 (192.7); 2.7185 (0.4); 2.6829 (0.6); 2.6788 (0.8); 2.6744 (0.6); 2.5607 (16.0); 2.5489 (59.6); 2.5139 (91.7); 2.5095 (121.6); 2.5052 (93.9); 2.3363 (0.8); 2.3319 (0.6)
I-388:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 20.0082 (0.4); 9.0215 (2.0); 9.0063 (3.8); 8.9926 (2.0); 8.3142 (0.8); 8.1114 (0.3); 8.0811 (16.0); 7.7668 (1.6); 7.7465 (4.5); 7.7262 (4.5); 7.7093 (6.3); 7.6872 (12.9); 7.6654 (9.9); 7.6042 (3.8); 7.5841 (3.1); 7.5001 (0.7); 7.4796 (0.8); 7.3076 (0.3); 7.2328 (9.1); 7.2123 (8.4); 7.0706 (0.6); 7.0493 (0.6); 6.3043 (0.3); 5.7555 (3.5); 5.7465 (2.0); 5.7316 (1.3); 5.6412 (1.2); 5.6303 (1.7); 5.6132 (1.3); 4.0550 (0.5); 4.0371 (1.5); 4.0196 (1.6); 4.0017 (0.5); 3.8644 (0.4); 3.8479 (0.4); 3.8299 (1.3); 3.8137 (2.4); 3.7969 (2.7); 3.7789 (2.1); 3.7624 (2.0); 3.7460 (2.1); 3.7324 (1.6); 3.7206 (1.1); 3.6992 (0.6); 3.5285 (0.5); 3.5140 (0.4); 3.3178 (163.2); 3.1424 (0.3); 2.8079 (0.4); 2.7889 (0.5); 2.6700 (4.2); 2.5049 (593.4); 2.5008 (756.4); 2.4966 (556.9); 2.3277 (4.3); 1.9881 (6.5); 1.3976 (1.3); 1.3834 (0.8); 1.3072 (0.4); 1.2929 (0.5); 1.2347 (2.0); 1.1923 (1.9); 1.1744 (3.8); 1.1566 (2.1); 1.1470 (1.0); 0.8798 (1.2); 0.8526 (0.4); 0.1452 (1.7); -0.0004 (369.0); -0.1501 (1.8)
I-389:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1918 (0.4); 8.1729 (0.8); 8.1525 (0.4); 7.5650 (1.2); 7.5420 (3.7); 7.5196 (0.4); 7.4991 (1.7); 7.4654 (0.8); 7.4566 (1.3); 7.4493 (0.8); 7.4351 (2.3); 7.4088 (1.9); 7.2991 (14.3); 7.0962 (1.9); 7.0595 (1.0); 7.0327 (0.9); 5.3382 (1.6); 4.2626 (0.9); 4.2425 (0.9); 4.2123 (1.9); 4.1923 (1.8); 4.1621 (1.0); 4.1423 (1.1); 3.8554 (1.6); 3.8368 (3.1); 3.8175 (1.8); 3.3993 (16.0); 3.1162 (1.8); 3.0973 (2.9); 3.0784 (1.6); 2.5421 (5.6); 2.5352 (3.2); 2.3266 (7.6); 1.5856 (7.9); 0.1087 (0.4); 0.0498 (0.5); 0.0390 (14.4); 0.0313 (0.4); 0.0297 (0.4); 0.0281 (0.5)
I-390:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9918 (3.2); 8.9864 (3.3); 8.9778 (3.3); 8.9724 (3.2); 8.4964 (2.2); 8.4935 (2.6); 8.4916 (2.6); 8.4678 (2.4); 8.4650 (2.8); 8.3765 (0.4); 8.3690 (16.0); 8.3612 (0.4); 8.1570 (2.8); 8.1289 (3.3); 7.9665 (1.4); 7.7451 (2.7); 7.7215 (4.3); 7.7171 (2.6); 7.6933 (3.8); 7.6290 (3.8); 7.6074 (3.1); 7.5839 (8.4); 7.5612 (3.6); 7.5351 (1.0); 7.4975 (3.7); 7.4835 (3.6); 7.4689 (3.4); 7.4549 (3.4); 7.3795 (3.7); 7.3778 (3.7); 7.3251 (1.6); 7.3176 (2.2); 7.3103 (1.2); 7.3073 (1.2); 7.2983 (16.3); 7.2873 (1.2); 5.3342 (6.4); 5.2244 (8.3); 5.2055 (8.2); 2.1482 (0.4); 2.0779 (0.4); 1.6916 (1.2); 1.2903 (0.4); 0.1067 (3.9); 0.0458 (0.4); 0.0425 (0.3); 0.0351 (12.2); 0.0241 (0.4)
I-391:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7796 (5.0); 7.9360 (0.4); 7.5638 (1.6); 7.5439 (4.4); 7.5408 (3.9); 7.5280 (0.3); 7.5238 (0.3); 7.4451 (2.1); 7.4187 (0.9); 7.4087 (1.4); 7.4012 (1.0); 7.3965 (0.6); 7.3878 (0.9); 7.3731 (2.1); 7.3464 (2.3); 7.2996 (1.7); 7.0770 (2.3); 7.0419 (0.6); 7.0216 (1.0); 7.0013 (0.6); 6.9769 (1.3); 6.9503 (1.1); 4.2617 (1.0); 4.2410 (1.0); 4.2130 (2.1); 4.1922 (2.0); 4.1642 (1.1); 4.1434 (1.0); 2.9550 (3.2); 2.8537 (2.8); 2.5172 (6.7); 2.5106 (3.8); 2.3351 (16.0); 2.3223 (9.4); 1.2971 (0.6); 0.9198 (0.4); 0.1141 (0.4); 0.0383 (1.6)
I-392:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1870 (5.2); 7.9902 (0.7); 7.9640 (0.7); 7.6057 (1.4); 7.5850 (4.2); 7.5642 (0.3); 7.5172 (1.8); 7.4672 (0.8); 7.4573 (1.3); 7.4501 (0.9); 7.4439 (0.5); 7.4364 (0.8); 7.4286 (0.4); 7.2982 (1.1); 6.6135 (4.9); 5.3896 (0.6); 5.3655 (0.7); 2.7638 (16.0); 2.6026 (1.5); 2.5841 (0.9); 2.2979 (0.6); 2.2841 (0.5); 2.2717 (0.4); 2.2544 (0.4); 1.9491 (0.5); 1.9400 (0.5); 1.9231 (1.2); 1.9164 (1.3); 1.9063 (2.6); 1.8950 (1.4); 1.8859 (1.3); 1.8745 (0.5); 0.0304 (1.0)
I-393:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9613 (1.4); 8.9398 (1.5); 7.8086 (6.5); 7.7186 (0.6); 7.6991 (1.7); 7.6796 (1.5); 7.6399 (1.9); 7.6203 (3.6); 7.5819 (1.4); 7.5601 (1.1); 7.1942 (2.0); 7.1746 (2.3); 6.9078 (2.7); 6.8821 (1.5); 6.8619 (1.3); 5.1449 (0.8); 5.1279 (0.8); 5.1101 (0.3); 3.3396 (81.2); 2.7169 (0.6); 2.7009 (1.6); 2.6861 (1.7); 2.6718 (1.0); 2.6026 (16.0); 2.5415 (16.6); 2.5243 (1.1); 2.5108 (20.5); 2.5067 (40.0); 2.5022 (51.8); 2.4978 (38.0); 2.2127 (11.6); 2.0081 (0.3); 1.9948 (0.4); 1.9832 (0.6); 1.9723 (0.7); 1.9641 (0.6); 1.9506 (0.5); 1.8885 (0.4); 1.8748 (0.6); 1.8636 (0.6); 1.8445 (0.6); 1.7578 (1.0); 1.7404 (1.5); 1.7301 (1.1); 1.7171 (1.0); -0.0002 (1.0)
I-394:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1344 (2.7); 9.1155 (2.8); 8.1586 (15.4); 8.1546 (6.6); 7.9538 (0.4); 7.7510 (1.6); 7.7314 (4.8); 7.7118 (4.8); 7.6995 (6.7); 7.6868 (6.0); 7.6673 (2.6); 7.6243 (3.8); 7.6046 (2.6); 6.9821 (7.3); 6.9784 (9.0); 6.8776 (2.9); 6.8743 (2.9); 6.8576 (5.5); 6.8540 (5.7); 6.8150 (10.9); 6.7951 (5.8); 5.9559 (9.8); 5.9536 (14.0); 5.9427 (11.7); 5.9404 (12.5); 5.0864 (0.5); 5.0689 (2.2); 5.0506 (3.2); 5.0325 (2.3); 5.0148 (0.6); 3.3997 (44.8); 3.3884 (43.2); 3.3846 (50.6); 3.3737 (58.4); 2.8923 (2.5); 2.7338 (2.2); 2.5292 (0.6); 2.5158 (13.1); 2.5114 (27.5); 2.5068 (37.0); 2.5023 (26.7); 2.4979 (12.9); 1.4239 (16.0); 1.4065 (15.8); 1.2389 (0.4); -0.0002 (0.6)
I-395:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2307 (0.4); 9.0789 (2.0); 9.0633 (4.2); 9.0476 (2.1); 8.8146 (0.9); 8.8099 (0.9); 8.7212 (6.9); 8.7159 (6.9); 8.1821 (0.4); 8.1767 (0.4); 8.1618 (0.6); 8.1559 (0.5); 8.0021 (3.8); 7.9962 (3.8); 7.9809 (4.5); 7.9751 (4.5); 7.9614 (0.6); 7.8296 (0.7); 7.8086 (0.9); 7.7547 (16.0); 7.7400 (7.6); 7.7189 (6.5); 7.6310 (0.5); 7.6008 (2.0); 7.5838 (3.8); 7.5688 (3.9); 7.5514 (3.9); 7.5327 (2.5); 7.5182 (1.8); 7.4613 (3.6); 7.4415 (4.9); 7.4213 (2.1); 7.4112 (3.4); 7.2762 (7.3); 7.1412 (3.6); 4.2723 (2.2); 4.2571 (2.3); 4.2369 (5.1); 4.2212 (4.8); 4.2010 (2.8); 4.1856 (2.4); 3.3172 (390.2); 3.2682 (0.5); 2.8989 (3.2); 2.7400 (3.0); 2.5956 (40.6); 2.5134 (29.3); 2.5092 (38.3); 2.5050 (28.5); 2.4537 (4.2); 1.2454 (0.7)
I-396:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0785 (0.8); 9.0631 (1.7); 9.0476 (0.8); 7.7399 (0.8); 7.7202 (2.3); 7.7120 (6.6); 7.7009 (2.0); 7.6733 (2.2); 7.6538 (1.1); 7.6142 (2.8); 7.5617 (4.3); 7.5418 (4.5); 7.4877 (0.5); 7.4691 (1.7); 7.4514 (1.7); 7.4276 (3.0); 7.4086 (3.4); 7.3906 (1.1); 4.1399 (0.9); 4.1244 (1.0); 4.1039 (2.0); 4.0883 (2.0); 4.0677 (1.0); 4.0522 (1.0); 3.3300 (266.2); 2.6786 (1.0); 2.6743 (0.8); 2.6019 (16.0); 2.5489 (28.5); 2.5138 (112.2); 2.5095 (151.3); 2.5053 (124.2); 2.3362 (1.0); 2.3321 (0.8)
I-397:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2886 (7.3); 7.7733 (1.3); 7.6839 (5.3); 7.6725 (2.6); 7.6681 (2.8); 7.6645 (2.9); 7.6372 (0.5); 7.4369 (2.9); 7.3906 (1.2); 7.3820 (1.4); 7.3703 (1.5); 7.3634 (1.3); 7.3525 (0.8); 7.2972 (0.5); 7.0464 (2.8); 7.0209 (3.2); 6.9679 (3.3); 6.5062 (1.8); 6.4808 (1.6); 5.3208 (1.0); 3.6283 (3.2); 3.6118 (3.1); 2.4569 (16.0); 2.1702 (15.6); 2.1023 (0.4); 1.3108 (1.2); 1.0302 (1.3); 1.0096 (4.7); 0.9961 (2.1); 0.9719 (0.6); 0.9483 (0.8); 0.9239 (2.4); 0.9108 (4.9); 0.8903 (1.3)
I-398:1 H-NMR(400.1 MHz, CDCl3): δ= 8.1090 (0.6); 8.0946 (0.9); 8.0802 (0.5); 7.5493 (0.6); 7.5292 (4.1); 7.5085 (6.5); 7.4902 (0.6); 7.4478 (2.2); 7.4142 (3.7); 7.3925 (3.1); 7.3854 (1.8); 7.3803 (1.0); 7.3671 (1.0); 7.2601 (7.3); 4.1811 (1.0); 4.1659 (1.0); 4.1443 (2.1); 4.1292 (2.0); 4.1074 (1.0); 4.0923 (1.0); 3.7895 (2.0); 3.7754 (3.4); 3.7613 (2.0); 3.3566 (16.0); 3.0163 (2.1); 3.0019 (3.3); 2.9880 (1.9); 1.5542 (6.9); -0.0002 (5.7)
I-399:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2687 (15.7); 8.0164 (2.2); 7.9293 (1.9); 7.5523 (7.3); 7.4945 (1.2); 7.4783 (2.0); 7.4739 (3.0); 7.4579 (3.5); 7.4372 (1.9); 7.3794 (1.6); 7.3755 (1.4); 7.3585 (6.2); 7.3545 (6.6); 7.3440 (9.5); 7.3231 (2.3); 7.2597 (30.1); 7.1062 (1.5); 7.1006 (1.6); 7.0851 (2.6); 7.0815 (3.0); 7.0646 (1.4); 7.0592 (1.4); 7.0243 (2.7); 7.0193 (3.5); 6.9998 (6.4); 6.9782 (2.4); 6.9724 (3.5); 6.9668 (1.7); 6.0573 (1.4); 6.0493 (1.5); 6.0396 (1.5); 6.0317 (1.4); 5.9407 (1.4); 5.9328 (1.5); 5.9231 (1.5); 5.9153 (1.4); 4.2916 (0.7); 4.2835 (0.7); 4.2748 (0.8); 4.2668 (0.8); 4.2550 (0.9); 4.2469 (0.9); 4.2382 (0.9); 4.2300 (0.9); 4.2250 (0.9); 4.2165 (0.8); 4.2080 (0.8); 4.1998 (0.8); 4.1881 (0.9); 4.1800 (0.9); 4.1714 (0.9); 4.1634 (0.8); 3.8464 (0.8); 3.8339 (0.9); 3.8290 (0.9); 3.8160 (0.9); 3.8099 (0.8); 3.7927 (1.6); 3.7800 (1.6); 3.7627 (0.9); 3.7565 (0.8); 3.7437 (0.8); 3.7389 (0.8); 3.7261 (0.7); 2.9544 (16.0); 2.8820 (14.7); 1.5439 (11.9); 0.0078 (1.8); -0.0002 (44.3)
I-400:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7360 (1.3); 7.7163 (1.3); 7.5785 (0.7); 7.5525 (2.5); 7.5321 (6.3); 7.4766 (0.7); 7.4503 (0.6); 7.3987 (3.4); 7.3658 (1.6); 7.3566 (2.1); 7.3490 (1.8); 7.3307 (3.9); 7.2984 (11.9); 7.0372 (3.6); 6.9268 (2.0); 6.9007 (1.8); 5.3362 (3.0); 4.2192 (1.5); 4.1995 (1.5); 4.1711 (3.0); 4.1517 (2.9); 4.1231 (1.6); 4.1036 (1.5); 3.9669 (0.4); 3.0294 (0.7); 3.0199 (1.4); 3.0066 (1.4); 2.9963 (1.4); 2.9846 (1.0); 2.9741 (0.6); 2.8371 (16.0); 2.5549 (0.4); 2.5489 (0.4); 2.5229 (0.5); 2.4829 (10.5); 2.2991 (14.2); 1.6298 (2.8); 1.2950 (3.5); 0.9282 (1.1); 0.9052 (3.5); 0.8876 (3.8); 0.8656 (1.5); 0.8384 (0.4); 0.8134 (0.3); 0.7477 (1.3); 0.7327 (3.3); 0.7240 (3.7); 0.6962 (0.9); 0.1086 (0.8); 0.0381 (10.5)
I-401:1 H-NMR(300.2 MHz, CDCl3): δ= 9.2324 (13.9); 9.2164 (14.4); 8.3007 (0.5); 8.2899 (14.5); 8.2738 (13.9); 8.0023 (1.7); 7.9851 (2.9); 7.9662 (1.7); 7.7091 (1.0); 7.6828 (6.4); 7.6751 (5.3); 7.6707 (5.7); 7.6641 (16.0); 7.6608 (15.8); 7.6498 (1.5); 7.6448 (1.4); 7.5956 (0.5); 7.5783 (8.7); 7.5497 (11.9); 7.5365 (7.5); 7.5141 (7.6); 7.5105 (7.6); 7.5078 (8.1); 7.4986 (1.6); 7.4918 (1.0); 7.4827 (3.1); 7.4718 (4.6); 7.4649 (4.2); 7.4524 (3.3); 7.4444 (2.0); 7.2988 (18.5); 7.2940 (6.3); 7.2870 (5.3); 7.2654 (4.4); 7.2587 (4.3); 5.3357 (1.7); 4.5042 (4.5); 4.4837 (4.3); 4.4559 (9.4); 4.4354 (9.0); 4.4075 (4.7); 4.3870 (4.5); 3.4040 (0.6); 1.6284 (10.0); 0.0459 (0.5); 0.0351 (12.0); 0.0242 (0.4)
I-402:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1184 (2.9); 9.0982 (3.0); 8.1491 (16.0); 7.9532 (1.6); 7.7578 (1.3); 7.7383 (4.0); 7.7183 (8.7); 7.6939 (4.6); 7.6745 (2.1); 7.6309 (3.2); 7.6115 (2.1); 7.2561 (5.7); 7.1111 (2.8); 7.1076 (2.8); 7.0906 (3.0); 7.0870 (3.0); 6.6581 (6.2); 6.6377 (5.8); 5.0969 (0.5); 5.0795 (1.8); 5.0610 (2.6); 5.0427 (1.9); 5.0256 (0.5); 4.4756 (4.6); 4.4539 (8.5); 4.4317 (5.2); 3.3628 (58.9); 3.3562 (82.1); 3.0918 (0.5); 3.0704 (1.0); 3.0526 (1.7); 3.0315 (2.8); 3.0119 (2.3); 2.9920 (2.9); 2.9706 (1.6); 2.9534 (1.0); 2.9316 (0.5); 2.8914 (10.4); 2.7332 (9.1); 2.5134 (11.3); 2.5091 (23.4); 2.5047 (31.4); 2.5002 (23.1); 1.4282 (13.3); 1.4108 (13.2); 1.2404 (0.4); -0.0002 (0.6)
I-403:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9982 (1.9); 7.5280 (2.6); 7.5069 (3.5); 7.4940 (1.7); 7.4764 (4.1); 7.3930 (0.8); 7.3739 (1.7); 7.3557 (1.2); 7.3130 (1.6); 7.2930 (2.1); 7.2730 (1.0); 7.2604 (12.1); 7.1521 (1.7); 7.1486 (1.7); 7.1310 (1.5); 7.1275 (1.6); 7.0098 (1.3); 6.8728 (2.6); 6.7359 (1.3); 6.4034 (0.7); 6.3887 (1.2); 6.3731 (0.7); 4.4422 (1.2); 4.4260 (1.2); 4.4068 (2.4); 4.3907 (2.4); 4.3713 (1.3); 4.3551 (1.2); 2.9494 (11.8); 2.8726 (11.5); 2.6072 (0.5); 2.5913 (16.0); 2.2703 (15.9); 2.1768 (0.3); 1.5740 (5.6); -0.0002 (1.3)
I-404:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2138 (1.8); 9.1980 (3.6); 9.1822 (1.7); 8.0365 (13.2); 7.7710 (1.4); 7.7514 (4.1); 7.7317 (4.0); 7.7142 (4.9); 7.6946 (2.0); 7.6626 (5.5); 7.5912 (3.2); 7.5719 (2.5); 7.5221 (5.8); 7.3691 (3.9); 7.3480 (6.5); 7.2911 (3.8); 7.2697 (2.2); 4.1648 (1.6); 4.1491 (1.7); 4.1286 (3.6); 4.1127 (3.5); 4.0919 (1.8); 4.0763 (1.7); 3.3289 (360.4); 3.2913 (0.3); 2.6786 (1.6); 2.5487 (18.5); 2.5094 (249.0); 2.5056 (196.9); 2.4592 (16.0); 2.3362 (1.6); 0.0080 (0.5)
I-405:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3143 (13.1); 8.0135 (1.3); 7.6595 (1.1); 7.6333 (3.0); 7.6072 (2.3); 7.5485 (2.8); 7.5228 (1.6); 7.4183 (3.4); 7.3937 (2.0); 7.3904 (2.2); 7.3863 (1.8); 7.3721 (4.0); 7.3637 (2.0); 7.3597 (1.7); 7.3558 (1.4); 7.3458 (4.1); 7.3015 (26.1); 7.0782 (3.8); 6.9942 (2.1); 6.9674 (1.8); 6.9320 (2.2); 6.7444 (4.4); 6.5569 (2.2); 5.3411 (5.3); 4.3061 (2.0); 4.2863 (1.9); 4.2581 (4.3); 4.2382 (4.2); 4.2100 (2.2); 4.1902 (2.1); 2.5194 (6.3); 2.5124 (11.5); 2.5049 (6.4); 2.3241 (16.0); 1.5937 (17.9); 1.2950 (0.9); 0.9224 (0.6); 0.1105 (4.6); 0.0513 (0.8); 0.0404 (23.3); 0.0295 (0.8)
I-406:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0278 (0.5); 9.0136 (1.0); 8.9987 (0.5); 8.1178 (0.4); 8.0783 (5.1); 7.7550 (0.4); 7.7362 (1.3); 7.7166 (1.4); 7.7046 (1.8); 7.6857 (0.6); 7.6622 (1.9); 7.6387 (16.0); 7.5955 (1.1); 7.5758 (0.8); 5.9339 (0.3); 5.9212 (0.5); 5.9084 (0.3); 5.8162 (0.3); 5.8048 (0.5); 5.7907 (0.3); 5.7561 (1.0); 4.0382 (0.4); 4.0203 (0.4); 3.8914 (0.6); 3.8761 (0.5); 3.8687 (0.5); 3.8532 (0.5); 3.8363 (0.6); 3.8219 (0.6); 3.8090 (0.5); 3.3191 (22.3); 2.6751 (0.4); 2.6709 (0.6); 2.6661 (0.4); 2.5060 (75.2); 2.5016 (97.6); 2.4972 (70.3); 2.3328 (0.4); 2.3284 (0.6); 2.3237 (0.4); 1.9887 (1.6); 1.3321 (0.8); 1.3139 (0.8); 1.2957 (0.4); 1.2356 (0.8); 1.1927 (0.5); 1.1749 (0.9); 1.1571 (0.5); 0.8807 (1.0); 0.0079 (2.2); -0.0001 (50.8); -0.0082 (2.4)
I-407:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2663 (16.0); 8.0170 (0.7); 7.8278 (1.9); 7.5540 (7.3); 7.3975 (1.8); 7.3934 (1.5); 7.3766 (6.2); 7.3725 (6.4); 7.3607 (9.5); 7.3399 (2.5); 7.2595 (30.6); 7.2318 (4.2); 7.2147 (5.7); 7.2001 (5.4); 7.1912 (2.1); 7.1761 (0.6); 7.1688 (0.5); 7.1584 (1.5); 7.1544 (1.6); 7.1443 (2.8); 7.1384 (2.6); 7.1310 (1.6); 7.1221 (1.2); 7.1139 (0.8); 6.0663 (1.4); 6.0583 (1.5); 6.0492 (1.6); 6.0413 (1.4); 5.9501 (1.4); 5.9422 (1.5); 5.9330 (1.6); 5.9251 (1.4); 4.2844 (0.8); 4.2763 (0.8); 4.2678 (0.8); 4.2598 (0.8); 4.2478 (0.9); 4.2397 (0.9); 4.2314 (0.9); 4.2230 (1.0); 4.2194 (1.0); 4.2111 (0.8); 4.2025 (0.8); 4.1947 (0.8); 4.1824 (0.9); 4.1744 (0.9); 4.1661 (0.9); 4.1577 (0.8); 3.8944 (0.8); 3.8808 (1.0); 3.8776 (1.0); 3.8640 (0.9); 3.8578 (0.8); 3.8399 (1.6); 3.8266 (1.6); 3.8090 (1.0); 3.8026 (0.8); 3.7892 (0.9); 3.7857 (0.8); 3.7722 (0.7); 2.9546 (5.5); 2.8821 (5.0); 1.5382 (9.6); -0.0002 (45.1); -0.0082 (1.9)
I-408:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4683 (0.6); 7.6599 (0.9); 7.6406 (1.6); 7.6213 (0.9); 7.5892 (0.4); 7.5601 (4.6); 7.5552 (3.1); 7.5427 (7.5); 7.5289 (0.5); 7.4044 (3.6); 7.3785 (0.5); 7.3650 (1.7); 7.3561 (4.8); 7.3445 (2.0); 7.3293 (4.8); 7.2985 (2.6); 7.0797 (4.0); 6.9859 (2.2); 6.9593 (1.9); 5.0057 (0.4); 4.9968 (0.7); 4.9751 (6.0); 4.9702 (5.4); 4.9605 (6.7); 4.9436 (1.5); 4.9350 (0.8); 4.6381 (0.5); 4.6169 (2.1); 4.6066 (5.2); 4.5992 (4.3); 4.5890 (1.8); 4.5678 (0.4); 4.2324 (1.6); 4.2123 (1.6); 4.1838 (3.6); 4.1636 (3.4); 4.1353 (1.9); 4.1150 (1.8); 2.5059 (11.6); 2.4992 (6.7); 2.3274 (16.0); 2.3005 (0.4); 2.0746 (0.6); 1.7186 (3.4); 1.3696 (0.3); 1.3458 (0.8); 1.3060 (4.9); 1.2679 (0.4); 0.9427 (1.7); 0.9208 (5.5); 0.8976 (2.0); 0.0395 (2.5)
I-409:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9978 (1.0); 7.5056 (0.7); 7.4885 (1.3); 7.4725 (0.8); 7.4028 (0.6); 7.3836 (1.4); 7.3645 (1.0); 7.3103 (3.9); 7.3049 (3.3); 7.2934 (1.9); 7.2731 (0.8); 7.2604 (11.5); 7.2084 (2.4); 7.1878 (2.9); 7.0242 (1.8); 7.0190 (1.8); 7.0036 (1.5); 6.9977 (2.2); 6.8590 (2.5); 6.7220 (1.2); 6.1258 (0.5); 6.1118 (0.9); 6.0974 (0.6); 3.8376 (1.2); 3.8214 (3.2); 3.8052 (3.3); 3.7890 (1.3); 3.0946 (2.3); 3.0778 (4.3); 3.0611 (2.1); 2.9495 (6.9); 2.8732 (6.4); 2.5973 (0.6); 2.5846 (16.0); 2.3124 (15.9); 2.1742 (0.4); 1.5654 (11.3); -0.0002 (1.2)
I-410:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3991 (1.9); 7.3725 (2.1); 7.2986 (9.9); 7.1118 (0.3); 7.1016 (0.3); 7.0872 (4.0); 7.0749 (3.7); 7.0710 (3.1); 7.0625 (2.7); 7.0438 (0.4); 6.9803 (1.1); 6.9536 (1.0); 6.8204 (0.7); 6.8070 (0.6); 6.7998 (1.0); 6.7884 (1.2); 6.7754 (0.6); 6.7666 (0.5); 6.4773 (0.4); 6.4563 (0.8); 6.4362 (0.4); 4.3001 (1.0); 4.2791 (1.0); 4.2519 (2.2); 4.2309 (2.1); 4.2037 (1.1); 4.1827 (1.1); 2.6207 (16.0); 2.5384 (6.2); 2.5314 (3.5); 2.3259 (8.4); 2.2778 (15.7); 2.1236 (0.6); 2.1130 (0.7); 2.0956 (1.0); 2.0782 (0.6); 2.0673 (0.6); 1.6130 (7.6); 1.0539 (0.8); 1.0388 (1.9); 1.0319 (2.1); 1.0258 (1.1); 1.0172 (1.2); 1.0101 (2.1); 1.0034 (1.9); 0.9890 (1.0); 0.8041 (1.0); 0.7893 (2.2); 0.7867 (2.0); 0.7829 (2.2); 0.7722 (2.0); 0.7666 (2.4); 0.7502 (0.8); 0.1083 (1.0); 0.0489 (0.4); 0.0382 (11.6); 0.0272 (0.4)
I-411:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0694 (0.7); 9.0538 (1.4); 9.0378 (0.7); 7.7331 (0.6); 7.7135 (1.8); 7.6935 (1.8); 7.6872 (6.6); 7.6654 (1.9); 7.6458 (0.9); 7.5980 (2.3); 7.5430 (1.3); 7.5231 (1.0); 7.3095 (2.2); 7.2895 (2.4); 7.0707 (2.5); 6.9254 (1.3); 6.9053 (1.2); 4.1176 (0.7); 4.1014 (0.7); 4.0802 (1.6); 4.0645 (1.6); 4.0429 (0.8); 4.0271 (0.8); 3.3195 (56.7); 2.6704 (0.4); 2.5920 (16.0); 2.5406 (23.6); 2.5101 (22.8); 2.5057 (44.8); 2.5011 (59.7); 2.4966 (45.0); 2.4921 (22.6); 2.4132 (6.6); 2.3280 (0.4); 2.2880 (0.3); 2.2209 (9.4)
I-412:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2661 (6.7); 7.7886 (0.9); 7.7734 (0.6); 7.6530 (0.4); 7.6512 (0.4); 7.6367 (3.7); 7.6335 (3.7); 7.6135 (1.8); 7.5874 (0.4); 7.3504 (2.3); 7.3336 (1.0); 7.3259 (1.1); 7.3174 (0.6); 7.3112 (1.0); 7.3039 (1.2); 7.2956 (0.5); 7.1440 (2.4); 7.1143 (1.1); 7.0898 (1.6); 7.0161 (1.0); 6.9912 (2.4); 6.9669 (1.6); 6.9495 (1.9); 6.9244 (0.7); 3.7198 (4.3); 3.7023 (4.2); 2.1647 (12.4); 2.0032 (3.5); 1.3114 (0.4); 0.9667 (16.0)
I-413:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1459 (1.2); 9.1304 (2.5); 9.1148 (1.2); 8.0032 (10.9); 7.9597 (0.9); 7.5798 (4.3); 7.5720 (2.8); 7.5631 (3.0); 7.5576 (6.7); 7.5353 (2.7); 7.3256 (4.4); 7.3051 (5.3); 7.2970 (1.9); 7.2879 (1.2); 7.0870 (4.4); 6.9582 (2.3); 6.9380 (2.1); 4.1325 (1.2); 4.1170 (1.2); 4.0956 (2.7); 4.0798 (2.6); 4.0582 (1.4); 4.0427 (1.3); 3.3482 (24.3); 2.8978 (5.9); 2.7389 (5.4); 2.5139 (29.9); 2.5095 (39.1); 2.5053 (29.7); 2.4221 (11.3); 2.2645 (0.8); 2.2443 (16.0); 2.1917 (0.5)
I-414:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2487 (3.5); 9.2293 (3.6); 8.2034 (16.0); 8.2006 (8.9); 7.9554 (0.5); 7.7562 (1.4); 7.7369 (4.2); 7.7173 (3.8); 7.6935 (11.4); 7.6735 (2.6); 7.6339 (3.8); 7.6142 (2.5); 7.4873 (1.5); 7.4829 (1.7); 7.4678 (1.6); 7.4631 (1.9); 7.4585 (1.9); 7.4526 (1.8); 7.4378 (1.6); 7.4333 (1.7); 7.3836 (1.4); 7.3623 (3.2); 7.3573 (1.8); 7.3411 (2.3); 7.3358 (3.3); 7.3148 (2.1); 7.2590 (2.2); 5.1640 (0.5); 5.1458 (2.0); 5.1277 (3.0); 5.1096 (2.1); 5.0925 (0.5); 3.3627 (44.2); 3.3558 (59.6); 3.3500 (66.2); 2.8933 (3.0); 2.7346 (2.8); 2.5108 (28.7); 2.5066 (38.1); 2.5024 (28.2); 1.4512 (14.8); 1.4337 (14.7); 1.2397 (0.6); -0.0002 (0.5)
I-415:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0030 (2.2); 7.5056 (0.8); 7.4882 (1.4); 7.4710 (0.9); 7.4349 (2.8); 7.4138 (4.2); 7.3931 (3.9); 7.3106 (1.3); 7.2908 (1.9); 7.2698 (0.9); 7.2609 (12.4); 7.2187 (1.7); 7.2139 (1.7); 7.1978 (1.4); 7.1930 (1.4); 7.0114 (1.2); 6.8744 (2.5); 6.7374 (1.2); 6.4548 (0.6); 6.4402 (1.0); 6.4254 (0.6); 6.0490 (0.6); 6.0412 (0.6); 6.0321 (0.6); 6.0243 (0.6); 5.9328 (0.6); 5.9249 (0.6); 5.9156 (0.6); 5.9080 (0.6); 4.1835 (0.4); 4.1755 (0.4); 4.1674 (0.4); 4.1589 (0.4); 4.1551 (0.4); 4.1385 (0.3); 4.1181 (0.4); 4.1101 (0.4); 4.1017 (0.4); 4.0937 (0.4); 3.9403 (0.4); 3.9243 (0.6); 3.9085 (0.4); 3.9040 (0.4); 3.8858 (0.7); 3.8704 (0.7); 3.8531 (0.4); 3.8485 (0.4); 3.8324 (0.4); 2.9507 (15.5); 2.8752 (14.5); 2.6020 (16.0); 2.5866 (0.5); 2.3086 (16.0); 1.5769 (4.6); -0.0002 (1.3)
I-416:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.0315 (0.7); 9.0155 (1.5); 9.0005 (0.8); 8.6063 (3.1); 8.6016 (3.3); 8.4804 (3.3); 8.4756 (3.1); 7.7484 (6.6); 7.7112 (0.6); 7.6916 (1.8); 7.6721 (1.7); 7.6507 (2.0); 7.6310 (0.9); 7.5852 (2.4); 7.5125 (1.3); 7.4929 (1.0); 4.3601 (0.7); 4.3446 (0.7); 4.3249 (1.6); 4.3091 (1.5); 4.2894 (0.8); 4.2737 (0.7); 3.3189 (553.9); 2.6744 (1.7); 2.6699 (2.3); 2.6656 (1.7); 2.5972 (16.0); 2.5233 (5.6); 2.5098 (130.9); 2.5053 (277.4); 2.5008 (389.2); 2.4962 (292.2); 2.4918 (139.8); 2.3322 (1.6); 2.3276 (2.3); 2.3232 (1.6); 1.0430 (0.5); 1.0280 (0.5); 0.1457 (0.6); 0.0079 (5.1); -0.0003 (148.6); -0.0085 (4.8); -0.1497 (0.7)
I-417:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3527 (0.4); 8.3340 (12.9); 8.3071 (1.7); 8.3036 (1.9); 8.3001 (2.0); 8.2968 (1.8); 8.2800 (2.0); 8.2764 (2.1); 8.2729 (2.3); 8.2696 (2.0); 8.1603 (2.9); 8.1529 (5.1); 8.1457 (2.7); 7.8816 (1.4); 7.8640 (0.8); 7.8247 (0.5); 7.7649 (2.3); 7.7376 (5.4); 7.7104 (3.4); 7.6526 (2.5); 7.6492 (2.8); 7.6449 (2.6); 7.6416 (2.4); 7.6254 (1.5); 7.6218 (1.7); 7.6176 (1.6); 7.6142 (1.4); 7.3810 (3.5); 7.3544 (4.0); 7.3013 (34.4); 7.0904 (3.9); 7.0234 (2.1); 6.9959 (1.8); 5.3413 (3.4); 4.3172 (2.0); 4.2974 (1.9); 4.2687 (4.2); 4.2489 (4.1); 4.2202 (2.2); 4.2005 (2.1); 2.5235 (6.4); 2.5167 (11.6); 2.5093 (6.5); 2.3900 (0.8); 2.3691 (0.4); 2.3603 (0.3); 2.3317 (16.0); 2.1932 (0.4); 1.5910 (12.3); 1.2934 (0.6); 0.1098 (0.5); 0.0507 (1.2); 0.0399 (35.0); 0.0289 (1.3)
I-418:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2420 (1.7); 9.2263 (3.5); 9.2106 (1.7); 8.0209 (16.0); 7.9935 (6.3); 7.7996 (3.9); 7.7791 (4.6); 7.7524 (1.3); 7.7329 (4.1); 7.7132 (5.2); 7.7052 (5.6); 7.6855 (1.7); 7.5973 (5.6); 7.5487 (3.4); 7.5294 (2.6); 7.4892 (3.3); 7.4685 (2.9); 4.3576 (1.6); 4.3419 (1.7); 4.3236 (3.6); 4.3078 (3.5); 4.2894 (1.8); 4.2735 (1.7); 3.3404 (142.2); 3.3340 (145.2); 2.7132 (0.3); 2.6768 (0.5); 2.6725 (0.7); 2.5428 (87.9); 2.5079 (99.4); 2.5035 (130.3); 2.4992 (94.5); 2.3689 (0.4); 2.3303 (0.7); 2.1683 (1.0); -0.0001 (3.5)
I-419:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5392 (3.7); 7.5293 (5.4); 7.4182 (2.8); 7.3671 (1.0); 7.3582 (1.5); 7.3552 (1.4); 7.3493 (1.1); 7.3442 (0.8); 7.2570 (3.6); 7.0573 (2.4); 7.0420 (2.9); 6.9634 (3.2); 6.8713 (1.8); 6.8562 (1.6); 6.0303 (0.7); 6.0190 (1.3); 6.0077 (0.8); 5.2939 (0.4); 3.7687 (1.3); 3.7554 (3.6); 3.7426 (3.8); 3.7293 (1.5); 2.9612 (2.4); 2.9474 (4.8); 2.9337 (2.4); 2.2980 (16.0); 2.2803 (0.9); 2.2532 (15.1); 2.2118 (0.7); 1.5521 (3.2); 1.2566 (0.5); -0.0002 (3.6)
I-420:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1209 (3.3); 9.0996 (3.4); 8.2014 (16.0); 7.7495 (1.1); 7.7297 (3.5); 7.7091 (3.5); 7.6827 (9.6); 7.6668 (2.2); 7.6292 (3.3); 7.6097 (2.2); 7.3453 (6.0); 7.2928 (1.5); 7.2718 (9.6); 7.2670 (7.3); 7.2626 (5.7); 7.2457 (0.9); 7.2414 (1.0); 5.7555 (11.2); 5.1539 (0.8); 5.1390 (1.7); 5.1211 (1.8); 5.1043 (0.8); 3.3197 (40.7); 2.8010 (0.4); 2.7745 (1.3); 2.7580 (3.4); 2.7437 (3.6); 2.7299 (1.5); 2.7007 (0.5); 2.6749 (0.9); 2.6705 (1.1); 2.6664 (0.8); 2.5058 (139.3); 2.5015 (180.1); 2.4971 (133.7); 2.3325 (0.8); 2.3281 (1.0); 2.3239 (0.8); 2.0259 (0.8); 2.0122 (0.9); 1.9879 (1.6); 1.9685 (1.0); 1.8953 (0.4); 1.8539 (1.2); 1.8350 (1.3); 1.8118 (0.9); 1.7902 (1.9); 1.7670 (3.0); 1.7500 (2.1); 1.3555 (1.4); 1.2340 (0.5); 0.0078 (1.3); -0.0002 (32.6); -0.0083 (1.2)
I-421:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2655 (10.6); 8.0157 (2.3); 7.8664 (1.5); 7.5606 (5.5); 7.4665 (2.6); 7.4595 (3.0); 7.4527 (2.8); 7.4457 (2.7); 7.4098 (1.8); 7.4058 (1.8); 7.3889 (3.8); 7.3849 (4.0); 7.3527 (6.1); 7.3319 (2.8); 7.2722 (2.2); 7.2598 (24.6); 7.2505 (4.3); 7.2305 (3.2); 7.1765 (1.7); 7.1677 (2.6); 7.1600 (1.8); 7.1546 (1.3); 7.1453 (1.6); 7.1377 (1.0); 6.0562 (1.0); 6.0479 (1.1); 6.0381 (1.1); 6.0301 (1.1); 5.9392 (1.0); 5.9314 (1.1); 5.9215 (1.1); 5.9135 (1.1); 4.2937 (0.5); 4.2863 (0.6); 4.2772 (0.6); 4.2691 (0.6); 4.2572 (0.6); 4.2493 (0.7); 4.2405 (0.6); 4.2325 (0.7); 4.2264 (0.6); 4.2181 (0.6); 4.2093 (0.6); 4.2013 (0.5); 4.1897 (0.7); 4.1814 (0.6); 4.1728 (0.7); 4.1649 (0.6); 3.8361 (0.6); 3.8231 (0.7); 3.8184 (0.8); 3.8054 (0.8); 3.7998 (0.7); 3.7823 (1.1); 3.7696 (1.1); 3.7530 (0.7); 3.7472 (0.6); 3.7344 (0.6); 3.7294 (0.6); 3.7164 (0.5); 2.9544 (16.0); 2.8816 (15.4); 1.5436 (9.5); -0.0002 (36.0)
I-422:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5620 (1.2); 7.5539 (1.0); 7.5494 (1.1); 7.5431 (3.3); 7.5397 (3.2); 7.5332 (2.1); 7.5041 (2.9); 7.4468 (1.4); 7.4148 (2.8); 7.3869 (2.0); 7.3790 (1.1); 7.3720 (0.9); 7.3594 (0.6); 7.3516 (0.4); 7.2984 (3.3); 7.2245 (0.4); 7.2039 (0.7); 7.1833 (0.4); 4.5292 (1.9); 4.5210 (1.4); 4.5151 (2.0); 4.5087 (1.4); 4.5006 (2.0); 4.2164 (0.7); 4.1953 (0.7); 4.1682 (1.6); 4.1471 (1.5); 4.1200 (0.8); 4.0989 (0.8); 3.7525 (2.1); 3.7446 (1.4); 3.7381 (2.0); 3.7321 (1.4); 3.7239 (1.9); 3.4432 (16.0); 1.6451 (0.3); 1.2924 (0.5); 0.1086 (0.7); 0.0367 (2.8)
I-423:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1095 (0.8); 9.0977 (1.8); 9.0857 (0.8); 7.7116 (0.8); 7.6957 (2.0); 7.6798 (1.5); 7.6370 (2.0); 7.6322 (2.5); 7.6300 (2.6); 7.6282 (2.6); 7.6262 (2.6); 7.6219 (1.3); 7.5516 (2.8); 7.5346 (4.7); 7.5303 (2.7); 7.4993 (1.4); 7.4832 (1.2); 7.3776 (1.9); 7.3734 (1.8); 7.3608 (1.6); 7.3566 (1.6); 6.0269 (0.5); 6.0168 (1.1); 6.0066 (0.5); 5.9345 (0.5); 5.9245 (1.1); 5.9142 (0.6); 3.9166 (1.0); 3.9055 (1.6); 3.8943 (1.0); 3.8701 (0.9); 3.8590 (1.6); 3.8478 (1.0); 3.3267 (10.1); 2.5424 (16.3); 2.5132 (0.7); 2.5096 (1.4); 2.5060 (1.9); 2.5024 (1.4); 2.4989 (0.6); 2.1726 (16.0)
I-424:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5390 (0.5); 7.5169 (1.0); 7.4943 (0.6); 7.4508 (0.5); 7.4264 (1.1); 7.4238 (1.1); 7.3987 (2.5); 7.3719 (2.1); 7.3383 (1.1); 7.3107 (1.5); 7.2985 (12.2); 7.2847 (0.6); 7.0848 (2.7); 6.9892 (1.1); 6.9629 (0.9); 6.9028 (2.3); 6.7202 (1.1); 6.3936 (0.4); 6.3729 (0.8); 6.3527 (0.4); 4.3036 (1.0); 4.2827 (1.0); 4.2552 (2.2); 4.2342 (2.1); 4.2068 (1.1); 4.1858 (1.1); 2.6328 (16.0); 2.5364 (6.1); 2.5294 (3.5); 2.3198 (8.3); 2.3002 (15.7); 2.0814 (0.4); 2.0423 (0.4); 1.6497 (1.0); 0.1080 (0.7); 0.0490 (0.4); 0.0381 (14.3); 0.0272 (0.5)
I-425:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1804 (2.2); 9.1649 (4.6); 9.1493 (2.2); 8.0697 (16.0); 7.7972 (7.4); 7.7765 (11.3); 7.7601 (1.8); 7.7406 (5.3); 7.7207 (6.9); 7.7060 (13.4); 7.6845 (7.6); 7.6253 (7.3); 7.5745 (4.4); 7.5555 (3.3); 4.2192 (2.2); 4.2034 (2.3); 4.1849 (4.9); 4.1690 (4.8); 4.1504 (2.5); 4.1345 (2.3); 3.3293 (226.9); 2.7189 (0.3); 2.6790 (1.2); 2.6751 (0.9); 2.5495 (72.7); 2.5137 (133.7); 2.5099 (176.4); 2.5058 (141.2); 2.3756 (0.4); 2.3367 (1.1)
I-426:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9790 (1.4); 8.9652 (2.9); 8.9517 (1.5); 8.1216 (16.0); 8.1152 (1.4); 7.7209 (4.9); 7.7163 (5.3); 7.6931 (1.0); 7.6733 (3.1); 7.6530 (5.6); 7.6424 (11.1); 7.6197 (3.1); 7.6152 (2.6); 7.5723 (3.3); 7.5534 (2.2); 7.3606 (4.1); 7.3388 (3.6); 4.3373 (3.5); 4.3244 (7.0); 4.3113 (3.8); 4.2771 (0.4); 3.7774 (2.0); 3.7642 (5.1); 3.7508 (5.2); 3.7375 (2.1); 3.3401 (77.2); 3.3349 (82.5); 2.6738 (0.3); 2.5440 (38.1); 2.5269 (1.2); 2.5133 (22.9); 2.5091 (46.1); 2.5047 (61.0); 2.5002 (44.0); 2.4960 (21.4); 2.3313 (0.3); -0.0002 (1.7)
I-427:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1459 (0.9); 9.1304 (1.9); 9.1147 (0.9); 7.9724 (9.3); 7.4725 (2.7); 7.4513 (3.0); 7.3555 (3.8); 7.3496 (4.0); 7.3226 (2.7); 7.3026 (3.1); 7.1609 (2.2); 7.1549 (2.1); 7.1401 (2.0); 7.1341 (1.9); 7.0875 (3.3); 6.9588 (1.8); 6.9385 (1.6); 4.1252 (0.9); 4.1095 (0.9); 4.0880 (2.1); 4.0722 (2.0); 4.0509 (1.0); 4.0350 (1.0); 3.3434 (26.7); 2.5138 (28.2); 2.5093 (36.9); 2.5049 (27.7); 2.4208 (8.6); 2.3703 (16.0); 2.2632 (0.6); 2.2447 (12.1); 2.1939 (0.3)
I-428:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6840 (1.5); 7.6808 (1.5); 7.6783 (1.5); 7.6023 (0.3); 7.5762 (1.0); 7.5507 (2.7); 7.5252 (0.4); 7.5045 (1.4); 7.4762 (3.4); 7.4175 (0.7); 7.4107 (1.1); 7.4032 (0.7); 7.3828 (1.5); 7.3769 (1.3); 7.3547 (0.8); 7.3486 (0.8); 7.2986 (19.9); 6.3890 (0.4); 6.3678 (0.7); 6.3476 (0.4); 5.3379 (0.5); 4.4804 (0.8); 4.4589 (0.7); 4.4322 (1.6); 4.4107 (1.6); 4.3840 (0.8); 4.3624 (0.8); 4.1929 (1.1); 4.1691 (3.4); 4.1453 (3.5); 4.1215 (1.2); 2.6651 (0.4); 2.6458 (11.3); 2.3097 (11.2); 2.0819 (16.0); 1.5994 (4.2); 1.3200 (4.4); 1.2962 (8.8); 1.2724 (4.2); 0.0476 (0.9); 0.0368 (20.5); 0.0259 (0.8)
I-429:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2724 (13.3); 8.0154 (2.2); 7.7861 (1.8); 7.5647 (6.1); 7.4187 (2.3); 7.4145 (2.1); 7.3979 (4.3); 7.3936 (4.2); 7.3511 (6.8); 7.3303 (3.7); 7.2908 (1.9); 7.2862 (3.0); 7.2815 (2.2); 7.2710 (2.2); 7.2597 (32.6); 7.2151 (5.2); 7.2127 (5.2); 6.9732 (1.8); 6.9678 (3.3); 6.9624 (1.9); 6.9515 (2.0); 6.9461 (3.4); 6.9407 (1.9); 6.0522 (1.1); 6.0442 (1.3); 6.0343 (1.3); 6.0262 (1.2); 5.9354 (1.2); 5.9276 (1.3); 5.9174 (1.3); 5.9095 (1.3); 4.2895 (0.6); 4.2811 (0.7); 4.2725 (0.7); 4.2643 (0.7); 4.2526 (0.8); 4.2445 (0.8); 4.2355 (0.8); 4.2276 (0.8); 4.2213 (0.8); 4.2134 (0.7); 4.2044 (0.7); 4.1964 (0.7); 4.1848 (0.8); 4.1764 (0.8); 4.1678 (0.9); 4.1598 (0.8); 3.8330 (0.8); 3.8199 (0.8); 3.8149 (0.9); 3.8022 (0.8); 3.7964 (0.8); 3.7809 (1.2); 3.7671 (1.3); 3.7502 (0.9); 3.7444 (0.8); 3.7314 (0.8); 3.7261 (0.8); 3.7135 (0.7); 2.9546 (16.0); 2.8818 (14.9); 1.5415 (13.1); -0.0002 (46.6)
I-430:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7477 (0.8); 8.7333 (0.8); 7.9314 (0.5); 7.9256 (0.5); 7.9055 (1.1); 7.8998 (1.1); 7.8796 (0.7); 7.8739 (0.6); 7.6079 (2.0); 7.5864 (3.0); 7.5820 (2.5); 7.5645 (0.4); 7.5296 (1.2); 7.4963 (0.6); 7.4878 (1.0); 7.4767 (1.0); 7.4731 (1.0); 7.4604 (1.0); 7.4568 (1.0); 7.4512 (0.8); 7.4475 (0.6); 7.4348 (0.6); 7.4312 (0.6); 7.2987 (17.2); 7.2625 (1.1); 7.2358 (1.3); 7.0321 (1.3); 6.9542 (0.7); 6.9279 (0.6); 6.6989 (0.6); 4.0318 (0.6); 4.0112 (0.6); 3.9821 (1.3); 3.9615 (1.2); 3.9324 (0.7); 3.9117 (0.6); 2.4159 (3.8); 2.4086 (2.1); 2.2964 (5.0); 1.6141 (16.0); 0.0485 (0.8); 0.0378 (17.4); 0.0268 (0.7)
I-431:1 H-NMR(499.9 MHz, CDCl3): δ= 8.8387 (5.6); 8.5089 (1.7); 7.9482 (0.7); 7.9366 (1.3); 7.9249 (0.7); 7.6626 (0.5); 7.6469 (1.9); 7.6319 (7.2); 7.5169 (2.6); 7.4682 (2.1); 7.4512 (4.3); 7.4327 (1.3); 7.4048 (2.0); 7.4024 (2.0); 7.3880 (1.2); 7.3853 (1.2); 7.2616 (5.2); 5.2993 (0.9); 4.4519 (1.0); 4.4397 (1.0); 4.4230 (2.2); 4.4108 (2.1); 4.3940 (1.1); 4.3818 (1.0); 2.4193 (16.0); 2.1373 (0.4); 1.6077 (4.1); 1.2549 (0.7); 1.2494 (0.3); 0.0715 (0.4); -0.0002 (3.6)
I-432:1 H-NMR(300.2 MHz, CDCl3): δ= 9.3908 (5.6); 8.0805 (4.6); 8.0716 (4.6); 7.8193 (5.2); 7.8143 (5.1); 7.5588 (5.7); 7.5418 (6.5); 7.5149 (0.5); 7.4688 (4.0); 7.4464 (0.6); 7.4338 (1.7); 7.4254 (1.6); 7.4170 (2.0); 7.4108 (1.6); 7.4038 (1.2); 7.3956 (0.9); 7.3572 (3.4); 7.3306 (3.8); 7.2985 (5.4); 7.0604 (5.1); 7.0365 (2.1); 7.0162 (1.2); 6.9531 (2.3); 6.9268 (2.0); 6.5709 (3.1); 6.5648 (3.9); 6.5565 (2.9); 4.2562 (1.6); 4.2355 (1.6); 4.2071 (3.2); 4.1866 (3.0); 4.1581 (1.6); 4.1488 (0.9); 4.1375 (1.5); 4.1250 (0.5); 2.4967 (11.9); 2.2978 (16.0); 2.0663 (1.7); 1.6835 (1.5); 1.3570 (0.3); 1.3105 (0.9); 1.2942 (2.0); 1.2870 (1.6); 1.2630 (0.7); 0.9550 (0.4); 0.9317 (0.4); 0.9176 (0.4); 0.8938 (0.3); 0.0374 (3.3)
I-433:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9089 (2.0); 8.1382 (5.7); 7.9526 (0.5); 7.7732 (0.4); 7.7535 (1.3); 7.7338 (1.3); 7.7214 (1.8); 7.7016 (1.4); 7.6821 (0.8); 7.6561 (1.0); 7.6366 (0.7); 7.3447 (2.7); 7.3242 (3.2); 7.0649 (2.7); 7.0450 (2.3); 3.3752 (29.6); 3.3657 (55.1); 2.8915 (3.6); 2.7328 (3.2); 2.5141 (5.8); 2.5097 (12.2); 2.5051 (16.5); 2.5006 (11.9); 2.4961 (5.7); 2.2439 (8.9); 1.6295 (16.0)
I-434:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5596 (1.4); 8.4037 (0.4); 8.3806 (0.4); 8.3193 (0.4); 8.0542 (0.7); 7.6783 (0.4); 7.6443 (0.5); 7.6346 (0.5); 7.6198 (0.5); 7.5542 (1.5); 7.5510 (1.5); 7.4734 (6.7); 7.4582 (6.8); 7.4370 (5.5); 7.3807 (3.0); 7.3179 (3.2); 7.2984 (27.8); 7.2316 (0.3); 7.1820 (0.3); 7.1614 (0.4); 7.0897 (0.6); 7.0295 (5.1); 6.9442 (2.6); 6.9178 (2.2); 5.3368 (0.6); 5.2673 (1.2); 4.4639 (0.5); 4.4403 (0.5); 4.3462 (2.2); 4.3259 (2.2); 4.3041 (2.2); 4.2062 (1.0); 4.1850 (0.8); 4.1679 (1.0); 4.1447 (1.5); 4.1352 (1.4); 4.0947 (2.0); 4.0445 (1.1); 2.9883 (1.1); 2.9040 (0.9); 2.5119 (1.4); 2.4444 (11.1); 2.3775 (0.4); 2.3351 (2.0); 2.2927 (16.0); 2.0811 (1.3); 1.3197 (0.4); 1.2958 (1.0); 1.2720 (0.4); 0.1079 (1.4); 0.0486 (1.1); 0.0379 (26.9); 0.0269 (1.2)
I-435:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1358 (0.8); 9.1199 (1.7); 9.1040 (0.8); 7.7338 (0.7); 7.7143 (2.0); 7.6944 (2.0); 7.6871 (6.6); 7.6690 (3.6); 7.6503 (2.4); 7.6289 (2.1); 7.5775 (2.6); 7.5344 (1.5); 7.5140 (1.2); 7.4327 (1.5); 7.4128 (1.2); 4.2068 (0.8); 4.1912 (0.8); 4.1708 (1.7); 4.1548 (1.6); 4.1344 (0.8); 4.1186 (0.8); 3.3793 (0.4); 3.3329 (348.7); 3.2931 (0.5); 3.2788 (0.3); 2.6833 (0.7); 2.6790 (1.0); 2.6745 (0.7); 2.5933 (16.0); 2.5623 (7.6); 2.5491 (33.6); 2.5142 (105.2); 2.5098 (140.9); 2.5054 (110.0); 2.3409 (0.6); 2.3367 (0.9); 2.3323 (0.6)
I-436:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2784 (16.0); 7.9526 (2.8); 7.6442 (1.5); 7.6249 (12.5); 7.6020 (5.5); 7.5756 (1.7); 7.3678 (6.7); 7.3116 (3.9); 7.3061 (3.8); 7.2959 (2.9); 7.2892 (3.6); 7.2676 (0.4); 7.1596 (4.9); 7.1352 (5.3); 6.9514 (2.5); 6.9260 (5.2); 6.9006 (3.1); 6.6417 (3.5); 6.6171 (6.1); 6.5925 (2.8); 6.3877 (6.2); 6.3618 (5.6); 4.1862 (0.6); 4.1624 (1.8); 4.1386 (1.8); 4.1148 (0.6); 3.9043 (0.8); 3.8871 (1.4); 3.8681 (1.3); 3.8587 (2.6); 3.8417 (4.6); 3.8222 (5.4); 3.8142 (4.0); 3.8059 (5.4); 3.7840 (7.2); 3.7538 (5.3); 3.7152 (1.6); 3.7019 (2.9); 3.6875 (2.9); 3.6725 (2.2); 3.6577 (1.5); 3.6432 (0.6); 3.4644 (4.0); 3.4519 (3.7); 3.4340 (3.6); 3.4217 (3.2); 3.3366 (2.9); 2.0759 (7.6); 1.3186 (2.4); 1.2949 (4.3); 1.2711 (2.1); 0.0444 (1.0)
I-437:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2234 (1.2); 9.2082 (2.5); 9.1926 (1.2); 8.0263 (12.6); 7.9599 (0.7); 7.8873 (5.5); 7.8657 (6.1); 7.4705 (5.7); 7.4492 (5.3); 7.3193 (3.7); 7.2993 (4.1); 7.0784 (4.3); 6.9374 (2.3); 6.9174 (2.1); 4.1263 (1.2); 4.1105 (1.2); 4.0889 (2.8); 4.0732 (2.6); 4.0517 (1.4); 4.0359 (1.3); 3.3487 (31.8); 2.8979 (4.7); 2.7390 (4.1); 2.6785 (0.4); 2.6740 (0.3); 2.5562 (0.4); 2.5421 (0.4); 2.5315 (1.3); 2.5181 (27.0); 2.5138 (53.1); 2.5093 (70.0); 2.5048 (52.2); 2.5006 (26.4); 2.4174 (11.4); 2.3405 (0.3); 2.3360 (0.5); 2.2589 (0.6); 2.2228 (16.0); 2.1777 (0.5)
I-438:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2913 (16.0); 7.6634 (2.1); 7.6379 (8.2); 7.6138 (3.2); 7.5884 (1.0); 7.3045 (87.2); 7.2867 (8.6); 7.2826 (8.6); 7.2669 (2.8); 7.2594 (3.5); 7.2512 (4.9); 7.0771 (1.8); 7.0713 (1.9); 7.0540 (3.0); 7.0487 (3.2); 7.0299 (1.7); 7.0241 (1.8); 6.9535 (0.5); 6.7601 (1.6); 6.7397 (5.4); 6.7334 (6.8); 6.7071 (3.3); 6.6828 (0.9); 5.3445 (14.5); 3.4227 (1.4); 3.4069 (2.8); 3.3973 (1.8); 3.3914 (1.8); 3.3819 (2.8); 3.3663 (1.5); 3.2514 (0.7); 3.2227 (1.1); 3.1988 (1.2); 3.1682 (1.8); 3.1382 (1.2); 3.0580 (1.8); 3.0296 (2.0); 3.0039 (1.0); 2.9793 (1.0); 2.4928 (1.2); 2.4614 (1.9); 2.4512 (1.6); 2.4292 (1.2); 2.4185 (2.4); 2.3866 (1.3); 2.0915 (1.6); 2.0866 (1.8); 2.0644 (1.7); 2.0587 (1.6); 2.0497 (1.5); 2.0432 (1.4); 2.0209 (1.4); 1.6073 (3.4); 1.5913 (69.1); 1.5607 (3.6); 1.3455 (3.3); 1.3292 (3.8); 1.3242 (3.4); 1.3081 (3.1); 1.2988 (1.3); 0.2388 (0.4); 0.0542 (2.8); 0.0433 (85.6); 0.0325 (3.0); -0.1547 (0.4)
I-439:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.8088 (1.6); 8.7946 (3.0); 8.7806 (1.5); 8.1222 (16.0); 7.7591 (1.2); 7.7394 (3.8); 7.7199 (4.0); 7.7050 (4.8); 7.6838 (6.3); 7.5893 (3.1); 7.5700 (2.4); 7.3161 (6.0); 7.2836 (4.0); 7.2635 (5.6); 7.1768 (3.7); 7.1734 (3.5); 7.1570 (2.6); 7.1530 (2.5); 5.7569 (10.6); 3.6105 (0.8); 3.5948 (1.7); 3.5778 (2.0); 3.5618 (3.0); 3.5465 (1.6); 3.5063 (1.3); 3.4907 (2.3); 3.4747 (2.3); 3.4571 (1.4); 3.4423 (1.1); 3.3939 (0.6); 3.3774 (1.8); 3.3596 (2.3); 3.3430 (1.7); 3.3201 (58.2); 2.9201 (0.6); 2.8985 (0.8); 2.8803 (1.6); 2.8640 (1.7); 2.8585 (1.6); 2.8432 (1.4); 2.8194 (1.2); 2.8009 (2.0); 2.7811 (1.7); 2.7591 (0.9); 2.7405 (0.6); 2.6749 (0.6); 2.6704 (0.8); 2.6667 (0.7); 2.5236 (2.7); 2.5059 (109.8); 2.5016 (142.2); 2.4972 (102.7); 2.3281 (0.8); 2.2395 (0.6); 2.2186 (1.2); 2.2044 (1.4); 2.1983 (1.0); 2.1925 (1.2); 2.1860 (1.7); 2.1720 (1.4); 2.1669 (0.9); 2.1517 (0.6); 1.9887 (0.7); 1.8974 (0.7); 1.8813 (1.4); 1.8762 (1.0); 1.8651 (1.6); 1.8603 (1.6); 1.8490 (1.4); 1.8439 (1.4); 1.8329 (0.9); 1.8282 (1.1); 1.8125 (0.6); 1.3558 (1.3); 1.2345 (0.6); 1.1745 (0.4); -0.0002 (1.2)
I-440:1 H-NMR(300.2 MHz, CDCl3): δ= 9.4687 (12.7); 8.9157 (6.4); 8.9095 (6.6); 8.0029 (6.6); 7.9967 (6.6); 7.5477 (4.9); 7.5302 (7.6); 7.5172 (0.7); 7.5053 (0.4); 7.4828 (3.8); 7.4602 (0.6); 7.4474 (1.7); 7.4391 (1.5); 7.4324 (2.1); 7.4258 (1.7); 7.4172 (1.2); 7.4091 (0.8); 7.3504 (3.5); 7.3237 (4.0); 7.2988 (6.9); 7.0695 (4.1); 7.0256 (1.1); 7.0052 (2.2); 6.9844 (1.2); 6.9659 (2.3); 6.9389 (2.0); 4.2759 (1.6); 4.2551 (1.5); 4.2265 (3.4); 4.2058 (3.2); 4.1771 (1.8); 4.1563 (1.7); 2.5021 (11.6); 2.3141 (16.0); 2.0690 (1.1); 1.6827 (8.7); 1.3119 (0.4); 1.2926 (0.8); 1.2882 (0.9); 1.2643 (0.4); 0.0368 (5.9)
I-441:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2919 (16.0); 7.8813 (1.1); 7.8627 (1.7); 7.6674 (1.3); 7.6442 (2.6); 7.6215 (1.8); 7.6009 (5.7); 7.5722 (8.2); 7.5376 (1.1); 7.5131 (2.6); 7.5107 (2.6); 7.4895 (2.0); 7.4515 (9.9); 7.4227 (8.7); 7.3924 (1.2); 7.2988 (22.9); 7.1352 (2.6); 6.9532 (5.4); 6.7711 (2.7); 5.3375 (0.6); 4.2718 (2.6); 4.2514 (2.5); 4.2249 (5.6); 4.2045 (5.4); 4.1781 (2.8); 4.1577 (2.7); 1.5873 (14.3); 1.2944 (0.9); 0.1083 (1.2); 0.0490 (0.7); 0.0381 (19.7); 0.0272 (0.8)
I-442:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6464 (0.4); 7.5931 (0.6); 7.5504 (7.7); 7.4680 (4.5); 7.4062 (5.2); 7.3797 (4.0); 7.2971 (6.2); 7.2878 (2.6); 7.0769 (4.9); 6.9940 (2.7); 6.9684 (2.6); 6.3738 (2.4); 4.2939 (1.6); 4.2734 (1.8); 4.2450 (3.3); 4.2252 (3.4); 4.1955 (1.8); 4.1773 (1.7); 3.1706 (1.8); 3.1458 (5.0); 3.1362 (2.7); 3.1212 (5.2); 3.1117 (2.4); 3.0967 (2.0); 2.5143 (13.4); 2.3089 (16.0); 1.6020 (2.2); 1.3566 (5.6); 1.3468 (3.5); 1.3320 (10.4); 1.3225 (5.0); 1.3074 (5.4); 1.2979 (2.5); 0.1072 (0.4); 0.0367 (5.8); 0.0275 (2.5)
I-443:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.8897 (0.8); 8.8756 (1.8); 8.8617 (0.9); 7.9597 (1.7); 7.7538 (0.7); 7.7343 (2.0); 7.7146 (2.0); 7.6976 (2.5); 7.6779 (1.1); 7.6303 (3.6); 7.6262 (3.6); 7.5756 (2.9); 7.5410 (1.6); 7.5213 (1.3); 7.3097 (1.2); 7.2891 (4.4); 7.2768 (3.2); 7.2725 (2.9); 7.2565 (0.9); 7.2520 (0.9); 3.6475 (0.9); 3.6316 (2.6); 3.6161 (2.7); 3.6004 (1.1); 3.3375 (121.1); 2.9568 (1.9); 2.9404 (3.7); 2.9240 (1.9); 2.8976 (9.9); 2.7382 (9.0); 2.5131 (10.5); 2.5091 (13.9); 2.5051 (10.6); 2.2724 (16.0)
I-444:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2420 (2.9); 9.2227 (3.0); 8.1850 (0.5); 8.1735 (16.0); 7.9551 (1.4); 7.7568 (1.3); 7.7372 (3.9); 7.7178 (3.7); 7.6954 (7.4); 7.6728 (2.2); 7.6291 (3.3); 7.6086 (2.2); 7.4978 (1.0); 7.4916 (8.7); 7.4872 (3.4); 7.4752 (3.6); 7.4704 (13.1); 7.4646 (2.1); 7.3802 (11.1); 7.3591 (7.8); 5.1340 (0.5); 5.1166 (1.9); 5.0985 (2.8); 5.0804 (1.9); 5.0629 (0.5); 3.3622 (33.3); 3.3593 (37.5); 3.3556 (42.9); 3.3518 (48.0); 2.8925 (9.6); 2.7344 (8.3); 2.5288 (0.4); 2.5154 (10.5); 2.5110 (22.2); 2.5065 (29.8); 2.5019 (21.5); 2.4975 (10.3); 1.4464 (13.8); 1.4289 (13.8); 1.2395 (0.6); -0.0002 (0.8)
I-445:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5988 (0.4); 7.5731 (1.3); 7.5470 (3.1); 7.5404 (1.8); 7.5194 (0.7); 7.5021 (1.9); 7.4774 (2.1); 7.4487 (5.0); 7.4422 (3.0); 7.4373 (2.1); 7.4252 (0.9); 7.2990 (11.9); 7.2752 (1.6); 7.2684 (1.5); 7.2473 (1.2); 7.2405 (1.1); 6.4183 (0.5); 6.3984 (0.8); 6.3781 (0.5); 6.1081 (0.5); 6.0977 (0.5); 6.0843 (0.5); 6.0742 (0.5); 5.9522 (0.5); 5.9422 (0.5); 5.9281 (0.5); 5.9183 (0.5); 4.2565 (0.4); 4.2461 (0.4); 4.2340 (0.3); 4.2237 (0.4); 4.1916 (0.4); 4.1674 (0.6); 4.1547 (0.4); 4.1435 (0.7); 4.1321 (0.4); 3.9439 (0.3); 3.9248 (0.4); 3.9201 (0.4); 3.9012 (0.4); 3.8950 (0.3); 3.8715 (0.6); 3.8526 (0.7); 3.8291 (0.4); 3.8229 (0.3); 3.0089 (1.2); 2.9840 (3.8); 2.9591 (3.8); 2.9342 (1.3); 2.3644 (16.0); 2.0814 (2.0); 1.6131 (3.2); 1.4108 (4.2); 1.3860 (8.8); 1.3611 (4.2); 1.3454 (0.7); 1.3194 (1.5); 1.3028 (3.4); 1.2959 (3.9); 1.2720 (0.9); 0.9404 (1.2); 0.9187 (3.6); 0.8954 (1.4); 0.0476 (0.4); 0.0367 (12.4); 0.0257 (0.5)
I-446:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3023 (13.4); 7.8772 (0.8); 7.8601 (1.3); 7.6633 (1.0); 7.6389 (1.9); 7.6166 (1.2); 7.5313 (0.9); 7.5068 (2.0); 7.5044 (2.0); 7.4832 (1.5); 7.4805 (1.4); 7.4353 (2.2); 7.4079 (2.7); 7.3806 (4.5); 7.3540 (4.1); 7.2987 (18.7); 7.1330 (2.2); 7.0707 (3.8); 6.9904 (2.1); 6.9639 (1.9); 6.9509 (4.5); 6.7687 (2.2); 5.3376 (1.0); 4.3079 (2.1); 4.2879 (2.0); 4.2601 (4.4); 4.2402 (4.2); 4.2124 (2.2); 4.1925 (2.2); 2.5191 (6.6); 2.5122 (11.8); 2.5047 (6.5); 2.3072 (16.0); 1.5881 (9.5); 1.2944 (0.6); 0.1090 (1.0); 0.0496 (0.6); 0.0388 (16.6); 0.0278 (0.6)
I-447:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3031 (13.0); 7.9551 (1.4); 7.5540 (1.5); 7.5507 (1.9); 7.5483 (1.8); 7.5449 (1.7); 7.5272 (2.4); 7.5240 (2.7); 7.5215 (2.9); 7.5183 (2.5); 7.4302 (3.5); 7.4228 (3.4); 7.4158 (5.0); 7.4091 (3.4); 7.4032 (6.0); 7.3759 (3.8); 7.3719 (3.8); 7.3449 (4.2); 7.3015 (34.9); 7.2240 (2.3); 7.2209 (2.4); 7.2165 (2.2); 7.2132 (2.1); 7.1965 (1.8); 7.1936 (1.8); 7.1890 (1.8); 7.1859 (1.6); 7.0839 (4.0); 7.0057 (2.1); 6.9789 (1.8); 5.3416 (5.7); 4.2989 (2.0); 4.2791 (2.0); 4.2509 (4.3); 4.2311 (4.2); 4.2029 (2.2); 4.1831 (2.1); 2.5190 (6.4); 2.5120 (11.8); 2.5046 (6.5); 2.4667 (0.4); 2.3721 (0.6); 2.3415 (16.0); 1.5890 (15.9); 1.2946 (0.6); 0.1102 (1.0); 0.0513 (1.1); 0.0405 (35.4); 0.0295 (1.2)
I-448:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3520 (14.5); 7.7986 (1.8); 7.7144 (0.4); 7.6870 (4.1); 7.6703 (8.4); 7.6671 (8.2); 7.6497 (0.8); 7.5593 (4.0); 7.5066 (1.7); 7.4930 (2.1); 7.4865 (2.2); 7.4767 (1.8); 7.4681 (1.0); 7.3038 (84.9); 7.2800 (1.2); 7.2641 (2.0); 7.2507 (3.2); 7.2377 (2.2); 7.2252 (7.0); 7.2142 (5.5); 7.2070 (3.8); 7.1959 (4.4); 6.9529 (0.3); 6.8143 (0.5); 6.8019 (2.5); 6.7903 (2.7); 6.7852 (2.0); 6.7729 (2.1); 3.3281 (1.4); 3.3141 (2.0); 3.3015 (2.2); 3.2884 (2.3); 3.2725 (1.5); 3.1403 (3.5); 3.1156 (5.6); 3.0904 (3.8); 2.1794 (4.9); 2.1677 (0.8); 2.1545 (6.6); 2.1295 (4.2); 2.0522 (16.0); 1.6492 (2.9); 1.6284 (3.7); 1.6230 (3.2); 1.6021 (4.3); 1.5905 (58.5); 1.3306 (0.3); 1.2984 (1.7); 1.1672 (2.4); 1.1501 (3.3); 1.1299 (2.3); 0.2383 (0.4); 0.0536 (2.9); 0.0428 (83.3); 0.0319 (2.7)
I-449:1 H-NMR(400.1 MHz, CDCl3): δ= 8.6908 (7.0); 8.6866 (7.2); 8.5134 (6.6); 8.5076 (6.9); 8.2671 (14.6); 8.0131 (2.4); 7.8265 (4.3); 7.8212 (7.3); 7.8161 (4.5); 7.7826 (2.3); 7.4870 (5.8); 7.4656 (12.2); 7.4280 (11.7); 7.4067 (5.9); 7.2602 (26.9); 4.2172 (2.6); 4.2021 (2.7); 4.1811 (5.7); 4.1660 (5.6); 4.1448 (3.0); 4.1297 (2.9); 2.9548 (16.0); 2.8804 (15.2); 1.5556 (1.5); -0.0002 (39.6)
I-450:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9235 (6.1); 8.4483 (3.3); 8.0161 (0.4); 7.9980 (0.7); 7.9789 (0.5); 7.6902 (1.4); 7.6698 (3.9); 7.6493 (0.3); 7.5860 (2.4); 7.5631 (1.7); 7.5041 (0.7); 7.4945 (1.2); 7.4872 (0.9); 7.4730 (0.8); 7.4661 (0.5); 7.3993 (3.6); 7.3950 (6.4); 7.2985 (10.2); 6.1409 (0.5); 6.1302 (0.6); 6.1169 (0.6); 6.1062 (0.5); 5.9853 (0.5); 5.9746 (0.6); 5.9614 (0.6); 5.9508 (0.5); 4.3284 (0.3); 4.3060 (0.3); 4.2484 (0.3); 4.2259 (0.3); 3.8987 (0.3); 3.8746 (0.3); 3.8457 (0.5); 3.8285 (0.5); 2.4644 (16.0); 1.6136 (9.1); 1.2934 (0.4); 0.0483 (0.3); 0.0375 (9.3)
I-451:1 H-NMR(499.9 MHz, CDCl3): δ= 8.8526 (5.5); 7.9193 (0.5); 7.9079 (1.0); 7.8967 (0.6); 7.6571 (0.3); 7.6411 (1.7); 7.6287 (4.1); 7.6282 (4.1); 7.4960 (2.3); 7.4831 (2.8); 7.4661 (4.1); 7.4350 (0.8); 7.4297 (1.3); 7.4253 (1.0); 7.4169 (1.0); 7.3908 (3.8); 7.3739 (2.7); 7.2623 (3.1); 5.2979 (1.6); 4.2276 (0.9); 4.2155 (0.9); 4.1991 (2.0); 4.1870 (2.0); 4.1705 (1.0); 4.1584 (1.0); 4.0690 (0.6); 3.9455 (16.0); 2.3756 (15.4); 2.3627 (0.7); 1.5785 (0.9); -0.0002 (3.0)
I-452:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9120 (5.6); 7.9800 (0.4); 7.9614 (0.6); 7.9435 (0.4); 7.6872 (1.3); 7.6773 (1.2); 7.6677 (3.6); 7.6645 (3.1); 7.6516 (0.5); 7.5892 (2.2); 7.5538 (1.6); 7.4948 (0.7); 7.4840 (1.0); 7.4767 (1.0); 7.4725 (0.6); 7.4640 (0.8); 7.4562 (0.5); 7.4326 (0.4); 7.4046 (2.6); 7.3986 (4.1); 7.3687 (0.4); 7.2982 (3.8); 6.1395 (0.4); 6.1289 (0.5); 6.1156 (0.5); 6.1049 (0.5); 5.9840 (0.5); 5.9733 (0.5); 5.9599 (0.5); 5.9493 (0.5); 5.3339 (1.3); 4.2186 (0.4); 4.0990 (0.8); 3.9813 (16.0); 3.8768 (0.3); 3.8599 (0.3); 3.8521 (0.4); 3.8308 (0.5); 3.8138 (0.4); 3.8077 (0.3); 2.4140 (15.0); 2.4011 (1.1); 1.6169 (1.0); 0.0354 (2.1)
I-453:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.8191 (0.8); 8.8051 (1.6); 8.7910 (0.8); 7.7526 (0.6); 7.7332 (1.9); 7.7134 (1.8); 7.6946 (2.2); 7.6750 (1.0); 7.5736 (2.6); 7.5380 (1.5); 7.5181 (1.2); 7.2763 (2.7); 7.2552 (5.8); 7.2199 (6.5); 7.1989 (3.1); 3.6123 (0.9); 3.5963 (2.4); 3.5808 (2.6); 3.5648 (1.1); 3.3165 (17.8); 2.8995 (1.1); 2.8535 (1.8); 2.8370 (3.4); 2.8206 (1.8); 2.7407 (1.0); 2.5141 (7.5); 2.5097 (10.3); 2.5054 (7.8); 2.2427 (16.0)
I-454:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.3231 (2.0); 9.3030 (2.0); 8.2034 (9.2); 7.9533 (0.6); 7.8290 (4.0); 7.7535 (6.4); 7.7447 (3.2); 7.7317 (3.8); 7.7247 (3.2); 7.7094 (3.3); 7.6899 (1.2); 7.6566 (2.2); 7.6277 (4.2); 7.5815 (2.7); 7.5606 (3.2); 7.5303 (2.3); 7.5264 (2.5); 7.5090 (1.9); 7.5052 (2.1); 7.2895 (2.3); 7.2862 (2.5); 7.2685 (2.0); 7.2651 (2.1); 5.3032 (1.2); 5.2851 (1.7); 5.2666 (1.2); 3.3617 (33.2); 3.3575 (32.8); 3.3488 (39.6); 2.8899 (3.6); 2.7322 (3.2); 2.5264 (0.5); 2.5129 (11.1); 2.5087 (22.9); 2.5042 (30.7); 2.4998 (22.3); 2.4394 (16.0); 2.3670 (0.3); 1.5490 (8.4); 1.5316 (8.3); -0.0002 (0.5)
I-455:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0317 (0.6); 7.5965 (2.5); 7.5756 (1.3); 7.5507 (3.0); 7.5421 (1.7); 7.5210 (0.7); 7.5047 (1.9); 7.4547 (0.9); 7.4484 (1.4); 7.4413 (0.7); 7.4327 (0.6); 7.4245 (0.9); 7.4170 (0.6); 7.4013 (6.6); 7.2986 (16.1); 6.4123 (0.5); 6.3918 (0.8); 6.3731 (0.5); 6.0932 (0.6); 6.0830 (0.6); 6.0694 (0.6); 6.0593 (0.6); 5.9375 (0.5); 5.9274 (0.6); 5.9138 (0.6); 5.9037 (0.5); 4.2566 (0.3); 4.2463 (0.4); 4.2342 (0.3); 4.2236 (0.4); 4.1654 (0.4); 4.1550 (0.3); 4.1428 (0.4); 4.1324 (0.3); 3.9454 (0.3); 3.9263 (0.4); 3.9216 (0.4); 3.9025 (0.4); 3.8728 (0.7); 3.8538 (0.7); 3.8302 (0.4); 3.0108 (1.2); 2.9859 (3.7); 2.9610 (3.8); 2.9362 (1.2); 2.3630 (16.0); 2.0447 (1.6); 1.6321 (0.7); 1.4112 (4.2); 1.3863 (8.8); 1.3711 (0.8); 1.3614 (3.9); 1.2932 (0.8); 0.0469 (0.6); 0.0361 (15.9); 0.0252 (0.5)
I-456:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4189 (1.1); 8.3988 (0.7); 8.3322 (10.8); 8.3212 (3.0); 8.3140 (2.9); 7.8540 (1.8); 7.8461 (1.8); 7.8258 (2.8); 7.8180 (2.7); 7.7259 (4.4); 7.6978 (2.8); 7.6637 (0.8); 7.6381 (1.5); 7.6236 (0.8); 7.6148 (0.8); 7.4821 (0.6); 7.4608 (1.7); 7.4401 (2.3); 7.4350 (4.6); 7.4107 (2.1); 7.3837 (0.7); 7.2985 (18.5); 7.1114 (1.8); 6.9294 (3.7); 6.7472 (1.8); 5.3373 (0.4); 4.5274 (1.8); 4.5069 (1.8); 4.4837 (3.8); 4.4632 (3.7); 4.4400 (1.9); 4.4195 (1.8); 1.5895 (16.0); 1.2934 (0.8); 0.1074 (1.1); 0.0481 (0.6); 0.0374 (16.7); 0.0265 (0.6)
I-457:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3869 (3.5); 7.3603 (4.0); 7.2987 (17.6); 7.1030 (0.8); 7.0756 (6.5); 7.0582 (9.2); 7.0549 (9.0); 7.0470 (4.8); 7.0283 (1.7); 7.0199 (1.1); 6.9815 (2.4); 6.9548 (2.1); 6.8324 (0.4); 6.8194 (1.4); 6.8032 (2.1); 6.7974 (1.7); 6.7884 (2.2); 6.7738 (1.2); 6.7657 (1.1); 4.2658 (1.8); 4.2452 (1.8); 4.2170 (3.9); 4.1961 (4.2); 4.1712 (2.6); 4.1477 (3.6); 4.1241 (0.7); 3.0999 (11.5); 3.0817 (11.4); 2.5124 (11.8); 2.3208 (16.0); 2.1544 (0.4); 2.1373 (0.9); 2.1262 (1.0); 2.1090 (2.0); 2.0915 (1.3); 2.0830 (9.1); 2.0634 (0.6); 1.5946 (10.3); 1.3695 (0.4); 1.3450 (0.9); 1.3214 (3.6); 1.3054 (6.0); 1.2977 (8.7); 1.2738 (2.5); 1.0672 (1.3); 1.0517 (3.4); 1.0451 (3.8); 1.0304 (2.0); 1.0231 (3.7); 1.0166 (3.5); 1.0021 (1.7); 0.9809 (0.3); 0.9739 (0.4); 0.9427 (2.1); 0.9209 (6.5); 0.8976 (2.4); 0.8094 (1.7); 0.7944 (4.1); 0.7885 (4.2); 0.7775 (3.7); 0.7716 (4.5); 0.7555 (1.3); 0.0497 (0.7); 0.0389 (21.4); 0.0280 (0.9)
I-458:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1071 (1.9); 9.0923 (3.9); 9.0776 (1.9); 8.0896 (16.0); 7.7743 (1.4); 7.7543 (4.0); 7.7338 (3.8); 7.7043 (10.6); 7.6875 (2.8); 7.6277 (3.9); 7.6050 (8.5); 7.5845 (5.9); 7.5634 (7.0); 7.3633 (4.1); 7.3583 (4.0); 7.3423 (3.5); 7.3373 (3.3); 6.0886 (1.2); 6.0756 (2.2); 6.0634 (1.2); 5.9732 (1.2); 5.9603 (2.4); 5.9480 (1.2); 4.0507 (0.3); 4.0330 (0.3); 3.9354 (2.2); 3.9209 (3.3); 3.9100 (1.6); 3.9058 (1.6); 3.8779 (2.4); 3.8637 (3.7); 3.8503 (1.8); 3.3533 (0.5); 2.5228 (0.8); 2.5186 (1.1); 2.5145 (0.8); 1.9986 (1.3); 1.3769 (0.5); 1.2027 (0.3); 1.1849 (0.7); 1.1671 (0.3); -0.0002 (0.6)
I-459:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3247 (0.3); 8.3040 (12.4); 7.9628 (1.3); 7.9453 (0.8); 7.4909 (1.8); 7.4640 (5.1); 7.4372 (4.1); 7.3985 (2.4); 7.3947 (3.3); 7.3924 (3.0); 7.3887 (2.8); 7.3719 (4.8); 7.3618 (1.5); 7.3456 (4.1); 7.3014 (22.8); 7.2686 (2.8); 7.2615 (5.0); 7.2548 (2.9); 7.1780 (2.2); 7.1743 (2.3); 7.1703 (2.1); 7.1668 (1.9); 7.1513 (1.9); 7.1475 (1.9); 7.1435 (1.8); 7.1399 (1.6); 7.0833 (4.0); 7.0039 (2.1); 6.9774 (1.8); 5.3411 (8.0); 4.2996 (2.0); 4.2798 (1.9); 4.2516 (4.3); 4.2318 (4.1); 4.2036 (2.2); 4.1838 (2.1); 2.5187 (6.5); 2.5117 (11.7); 2.5042 (6.4); 2.3726 (0.6); 2.3397 (16.0); 2.2488 (0.5); 1.5920 (11.5); 1.2958 (0.4); 0.0512 (0.9); 0.0404 (23.1); 0.0295 (0.8)
I-460:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5017 (3.6); 7.4888 (3.4); 7.3994 (2.3); 7.3712 (1.0); 7.3648 (1.0); 7.3579 (1.2); 7.3530 (1.0); 7.3487 (0.8); 7.3425 (0.6); 7.2588 (6.2); 7.2422 (4.1); 7.1327 (3.6); 7.1129 (2.6); 6.5405 (0.9); 6.5207 (1.0); 5.3356 (0.8); 5.3174 (1.2); 5.2990 (0.8); 2.3700 (0.9); 2.3569 (16.0); 2.3213 (11.8); 2.2665 (0.4); 1.7984 (0.3); 1.5932 (6.9); 1.5759 (7.2); 1.5687 (6.5); -0.0002 (3.9)
I-461:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5869 (8.4); 8.5853 (8.5); 7.9110 (1.4); 7.6659 (5.3); 7.6490 (6.5); 7.5096 (3.5); 7.4684 (1.4); 7.4602 (1.3); 7.4518 (1.8); 7.4469 (1.6); 7.4380 (1.2); 7.4299 (0.9); 7.3654 (3.4); 7.3388 (3.8); 7.3001 (12.6); 7.2985 (12.8); 7.0749 (4.0); 6.9880 (2.2); 6.9618 (1.9); 4.2992 (1.8); 4.2796 (1.7); 4.2512 (3.7); 4.2315 (3.6); 4.2030 (1.9); 4.1835 (1.8); 4.1722 (0.4); 2.5077 (11.5); 2.3192 (16.0); 2.0840 (1.3); 1.6293 (8.2); 1.3209 (0.4); 1.2968 (1.4); 1.2734 (0.4); 0.1089 (0.3); 0.0474 (0.8); 0.0391 (14.6); 0.0374 (14.3)
I-462:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2471 (16.0); 8.0127 (0.8); 7.9325 (2.0); 7.4853 (1.4); 7.4719 (7.3); 7.4503 (13.2); 7.4278 (2.4); 7.3947 (10.7); 7.3734 (6.2); 7.2593 (26.6); 7.1017 (1.6); 7.0970 (1.7); 7.0772 (3.0); 7.0602 (1.4); 7.0552 (1.5); 7.0103 (2.8); 7.0053 (3.7); 6.9863 (7.0); 6.9837 (6.4); 6.9660 (2.6); 6.9602 (3.7); 6.9546 (1.7); 4.2103 (2.8); 4.1952 (2.7); 4.1747 (5.9); 4.1596 (5.8); 4.1391 (3.1); 4.1240 (3.0); 2.9528 (5.9); 2.8800 (5.5); 1.5457 (18.9); 1.2559 (0.5); -0.0002 (2.1)
I-463:1 H-NMR(400.1 MHz, CDCl3): δ= 8.6935 (4.7); 8.6890 (4.7); 8.5217 (4.5); 8.5158 (4.6); 8.2571 (10.3); 8.0142 (2.1); 7.8354 (3.0); 7.8303 (4.8); 7.8248 (2.9); 7.7851 (0.8); 7.7721 (1.3); 7.7582 (0.8); 7.5541 (3.7); 7.5328 (4.4); 7.4985 (3.7); 7.4947 (3.8); 7.3130 (2.3); 7.3084 (2.2); 7.2918 (2.0); 7.2872 (2.0); 7.2604 (21.7); 4.4368 (1.7); 4.4216 (1.7); 4.4001 (3.6); 4.3848 (3.5); 4.3634 (1.8); 4.3481 (1.8); 2.9551 (16.0); 2.8810 (14.8); 1.5570 (1.5); 0.0077 (1.4); -0.0002 (32.0); -0.0080 (1.3)
I-464:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9987 (0.7); 7.5837 (1.5); 7.5683 (4.1); 7.5523 (0.4); 7.4319 (2.1); 7.3687 (0.7); 7.3619 (1.2); 7.3564 (0.9); 7.3434 (3.3); 7.3382 (3.2); 7.2851 (11.5); 7.2248 (2.1); 7.2043 (2.7); 7.0737 (1.7); 7.0684 (1.6); 7.0532 (1.3); 7.0480 (1.3); 6.1917 (0.5); 6.1769 (0.8); 6.1626 (0.5); 3.8640 (1.0); 3.8475 (2.8); 3.8315 (2.8); 3.8150 (1.1); 3.1202 (2.0); 3.1034 (3.8); 3.0866 (1.8); 2.9709 (5.1); 2.8866 (4.6); 2.4252 (16.0); 2.3182 (0.4); 1.5772 (6.4)
I-465:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1882 (0.9); 9.1727 (1.9); 9.1567 (1.0); 8.6193 (5.3); 8.3818 (2.9); 8.3698 (3.1); 8.1484 (6.2); 7.9605 (2.4); 7.8788 (3.5); 7.7922 (0.7); 7.7729 (2.0); 7.7534 (1.9); 7.7305 (2.6); 7.7084 (7.2); 7.6962 (3.4); 7.6274 (1.8); 7.6075 (1.5); 7.5109 (2.1); 7.4897 (3.3); 7.4176 (2.1); 7.3959 (1.4); 4.3336 (0.8); 4.3179 (0.9); 4.2996 (1.8); 4.2839 (1.8); 4.2652 (1.0); 4.2499 (0.9); 3.9992 (16.0); 3.3257 (106.7); 2.8986 (12.5); 2.7395 (11.9); 2.5094 (14.5)
I-466:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2959 (2.5); 9.2768 (2.6); 8.1978 (16.0); 7.9558 (1.6); 7.7605 (1.2); 7.7408 (3.8); 7.7211 (8.4); 7.6971 (4.4); 7.6774 (1.9); 7.6608 (6.2); 7.6558 (6.6); 7.6418 (3.2); 7.6212 (2.0); 7.5682 (6.3); 7.5579 (0.4); 7.5474 (8.3); 7.4188 (3.7); 7.4138 (3.7); 7.3979 (2.9); 7.3927 (2.9); 5.1686 (0.4); 5.1510 (1.8); 5.1328 (2.8); 5.1148 (1.9); 5.0969 (0.4); 3.3639 (29.5); 3.3540 (40.6); 3.3500 (42.5); 2.8937 (11.2); 2.7350 (9.6); 2.5296 (0.5); 2.5162 (11.7); 2.5118 (24.4); 2.5073 (32.6); 2.5027 (23.3); 2.4982 (11.2); 1.4557 (13.3); 1.4381 (13.2); 1.2392 (0.5); -0.0002 (0.8)
I-467:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2490 (16.0); 7.8181 (2.2); 7.6198 (1.8); 7.6022 (3.2); 7.5847 (2.1); 7.4925 (1.8); 7.4777 (9.1); 7.4567 (13.6); 7.3932 (12.0); 7.3761 (7.1); 7.3723 (7.4); 7.3577 (1.8); 7.2591 (26.9); 7.0465 (3.1); 6.9099 (6.3); 6.7733 (3.1); 5.2970 (0.7); 4.2226 (2.9); 4.2073 (2.8); 4.1875 (6.1); 4.1722 (5.9); 4.1524 (3.1); 4.1371 (2.9); 2.7227 (0.7); 2.0016 (0.9); 1.5386 (31.9); 1.2549 (0.4); -0.0002 (18.2)
I-468:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2846 (11.4); 8.1389 (1.3); 7.4130 (2.0); 7.3866 (4.5); 7.3688 (3.3); 7.3602 (3.0); 7.3424 (3.8); 7.2984 (34.0); 7.0898 (2.6); 7.0691 (4.6); 7.0266 (1.8); 7.0236 (1.8); 7.0186 (2.2); 7.0157 (2.0); 6.9997 (1.6); 6.9965 (1.7); 6.9885 (3.3); 6.9578 (1.8); 6.9427 (2.9); 6.9365 (3.7); 6.9296 (2.2); 5.3383 (16.0); 4.2876 (1.8); 4.2676 (1.7); 4.2394 (3.9); 4.2195 (3.7); 4.1913 (2.0); 4.1715 (1.9); 2.5102 (10.9); 2.5029 (6.0); 2.3295 (14.9); 2.0215 (0.4); 2.0045 (0.9); 1.9933 (1.0); 1.9766 (2.0); 1.9596 (1.1); 1.9485 (1.1); 1.9314 (0.5); 1.5813 (12.7); 1.0873 (1.3); 1.0720 (3.3); 1.0652 (3.6); 1.0501 (2.0); 1.0436 (3.6); 1.0372 (3.2); 1.0222 (1.6); 0.7992 (1.6); 0.7838 (4.2); 0.7780 (3.7); 0.7674 (3.4); 0.7617 (4.4); 0.7452 (1.2); 0.1077 (2.3); 0.0489 (1.4); 0.0382 (43.7); 0.0273 (1.6)
I-469:1 H-NMR(499.9 MHz, CDCl3): δ= 7.6202 (3.2); 7.5303 (3.4); 7.5205 (5.2); 7.4275 (2.8); 7.4132 (2.2); 7.3963 (3.1); 7.3337 (1.0); 7.3231 (3.3); 7.3066 (1.6); 7.2605 (3.6); 7.1900 (0.7); 7.1779 (1.3); 7.1659 (0.8); 4.3569 (1.0); 4.3441 (1.0); 4.3273 (2.1); 4.3146 (2.0); 4.2977 (1.1); 4.2850 (1.0); 4.1289 (0.8); 4.0306 (16.0); 4.0151 (0.5); 1.5819 (3.9); 1.3029 (0.3); 1.2891 (0.4); 1.2658 (1.2); 1.2564 (1.0); 0.8954 (0.7); 0.8818 (1.4); 0.8678 (0.7); -0.0002 (3.1)
I-470:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2416 (16.0); 8.0138 (0.8); 7.8152 (1.8); 7.4793 (6.3); 7.4579 (10.4); 7.4276 (0.4); 7.4130 (0.3); 7.3948 (9.8); 7.3734 (5.9); 7.2592 (30.1); 7.2473 (0.4); 7.2404 (0.4); 7.2273 (3.7); 7.2182 (2.9); 7.2094 (7.6); 7.1952 (4.7); 7.1884 (2.4); 7.1734 (0.5); 7.1538 (0.4); 7.1439 (1.4); 7.1396 (1.5); 7.1311 (2.5); 7.1232 (2.4); 7.1150 (1.7); 7.1085 (1.3); 7.1035 (0.9); 7.0993 (0.8); 4.2221 (2.7); 4.2068 (2.6); 4.1871 (5.7); 4.1718 (5.5); 4.1520 (2.9); 4.1368 (2.8); 2.9531 (5.7); 2.8802 (5.2); 1.5434 (17.4); -0.0002 (2.5)
I-471:1 H-NMR(400.1 MHz, CDCl3): δ= 8.6944 (4.4); 8.6900 (4.3); 8.5206 (4.1); 8.5148 (4.2); 8.2566 (9.3); 8.0147 (2.2); 7.8349 (2.8); 7.8298 (4.5); 7.8243 (2.6); 7.7803 (0.8); 7.7669 (1.3); 7.7529 (0.8); 7.6522 (4.4); 7.4847 (0.7); 7.4627 (8.7); 7.4361 (0.5); 7.2604 (21.5); 4.4343 (1.5); 4.4189 (1.5); 4.3976 (3.3); 4.3823 (3.2); 4.3609 (1.7); 4.3455 (1.6); 2.9550 (16.0); 2.8811 (15.0); 1.5538 (2.4); -0.0002 (31.0)
I-472:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2048 (1.1); 9.1893 (2.4); 9.1734 (1.2); 8.0119 (11.9); 7.7528 (0.9); 7.7338 (2.8); 7.7140 (2.9); 7.7001 (3.5); 7.6801 (1.3); 7.6364 (8.0); 7.5665 (2.2); 7.5406 (4.6); 7.5197 (4.4); 7.2793 (2.2); 7.2624 (2.0); 7.2586 (2.0); 5.7564 (0.6); 5.4606 (5.1); 5.1917 (4.1); 4.3087 (1.1); 4.2930 (1.1); 4.2741 (2.4); 4.2580 (2.3); 4.2394 (1.2); 4.2230 (1.2); 3.3214 (175.2); 2.6748 (1.1); 2.6703 (1.5); 2.6659 (1.1); 2.5410 (0.6); 2.5238 (3.4); 2.5102 (94.9); 2.5059 (200.3); 2.5015 (270.2); 2.4970 (193.9); 2.4927 (92.4); 2.3328 (1.1); 2.3282 (1.5); 2.3235 (1.1); 2.0083 (16.0); 0.1459 (1.2); 0.0079 (8.7); -0.0002 (267.7); -0.0084 (9.7); -0.1499 (1.2)
I-473:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9246 (5.4); 7.9720 (0.4); 7.9534 (0.7); 7.9343 (0.5); 7.6771 (1.4); 7.6565 (3.8); 7.6404 (0.4); 7.6358 (0.3); 7.5846 (2.3); 7.5551 (1.7); 7.4967 (0.7); 7.4873 (1.2); 7.4800 (0.9); 7.4740 (0.6); 7.4662 (0.8); 7.4587 (0.5); 7.4310 (0.4); 7.4030 (2.6); 7.3971 (3.4); 7.3936 (4.0); 7.3656 (0.5); 7.2983 (1.7); 6.1388 (0.5); 6.1283 (0.5); 6.1147 (0.6); 6.1041 (0.5); 5.9830 (0.5); 5.9725 (0.5); 5.9589 (0.6); 5.9484 (0.5); 4.3157 (0.3); 4.2342 (0.3); 4.2117 (0.3); 4.0969 (16.0); 3.8715 (0.3); 3.8644 (0.3); 3.8473 (0.3); 3.8191 (0.5); 3.8017 (0.4); 2.3986 (14.6); 1.6312 (0.7); 0.0341 (1.0)
I-474:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1412 (2.4); 9.1267 (5.1); 9.1122 (2.7); 7.9617 (2.2); 7.7587 (1.9); 7.7389 (5.8); 7.7193 (5.6); 7.7007 (7.0); 7.6815 (3.2); 7.6379 (8.1); 7.5805 (4.7); 7.5608 (3.8); 7.5164 (0.4); 7.4721 (8.2); 7.4511 (13.6); 7.3897 (14.6); 7.3688 (9.4); 5.8163 (1.4); 5.8049 (2.2); 5.7900 (1.6); 5.6985 (1.4); 5.6866 (2.2); 5.6719 (1.6); 3.9942 (0.4); 3.9470 (0.4); 3.9314 (0.8); 3.9107 (1.4); 3.8948 (2.8); 3.8867 (2.0); 3.8782 (2.9); 3.8603 (2.4); 3.8419 (2.8); 3.8269 (2.8); 3.8146 (2.2); 3.8021 (1.6); 3.7916 (0.7); 3.7777 (0.8); 3.7663 (0.5); 3.5693 (5.1); 3.5516 (12.1); 3.5342 (6.4); 3.4946 (0.4); 3.4278 (0.4); 3.3154 (46.2); 3.2539 (60.4); 3.2305 (1.5); 3.2027 (0.7); 3.0753 (0.4); 2.9741 (0.5); 2.9566 (1.0); 2.9409 (3.3); 2.9317 (3.7); 2.9242 (6.1); 2.9142 (6.3); 2.9068 (4.2); 2.8997 (16.0); 2.8819 (1.6); 2.8644 (0.7); 2.7408 (12.3); 2.5141 (27.2); 2.5098 (36.5); 2.5056 (27.6)
I-475:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1855 (1.0); 9.1697 (2.1); 9.1538 (1.1); 8.6183 (5.4); 8.3807 (2.9); 8.3687 (3.1); 8.1526 (5.1); 8.1501 (6.2); 7.9605 (2.4); 7.7899 (0.8); 7.7658 (4.6); 7.7512 (2.4); 7.7289 (3.0); 7.7074 (5.6); 7.6979 (6.2); 7.6257 (2.0); 7.6062 (1.7); 7.5854 (2.6); 7.5641 (2.9); 7.2806 (2.1); 7.2593 (1.9); 4.3389 (0.9); 4.3235 (1.0); 4.3051 (2.0); 4.2896 (2.0); 4.2712 (1.1); 4.2556 (1.0); 3.9968 (16.0); 3.3222 (117.4); 3.2733 (0.7); 2.8980 (11.4); 2.7390 (10.7); 2.5114 (14.6); 2.5081 (15.3)
I-476:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9914 (1.8); 8.1621 (5.0); 7.9542 (0.4); 7.7707 (0.4); 7.7510 (1.3); 7.7298 (1.7); 7.7235 (1.8); 7.6995 (1.4); 7.6799 (0.7); 7.6526 (1.0); 7.6333 (0.7); 7.5056 (1.5); 7.5004 (0.7); 7.4920 (1.7); 7.4834 (1.9); 7.4751 (0.8); 7.4699 (1.7); 7.0894 (1.7); 7.0843 (0.6); 7.0672 (3.3); 7.0502 (0.5); 7.0450 (1.6); 3.3800 (19.4); 3.3709 (33.2); 2.8929 (3.1); 2.7344 (2.7); 2.5158 (4.3); 2.5114 (9.0); 2.5069 (12.0); 2.5024 (8.6); 2.4979 (4.1); 1.6433 (16.0)
I-477:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1240 (5.1); 7.9204 (0.7); 7.9006 (0.4); 7.6343 (0.5); 7.6108 (1.0); 7.5875 (2.7); 7.5587 (3.3); 7.5315 (0.4); 7.5070 (1.0); 7.5044 (1.0); 7.4830 (0.7); 7.4803 (0.7); 7.4537 (3.6); 7.4247 (3.2); 7.3957 (1.3); 7.3681 (0.5); 7.2985 (8.8); 7.1304 (1.0); 6.9480 (2.2); 6.7657 (1.0); 4.2756 (1.0); 4.2551 (1.0); 4.2290 (2.2); 4.2086 (2.1); 4.1825 (1.1); 4.1620 (1.1); 2.7620 (16.0); 1.5925 (4.5); 0.0376 (9.0); 0.0267 (0.3)
I-478:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3043 (16.0); 7.9644 (1.1); 7.9464 (1.9); 7.9274 (1.1); 7.7295 (4.8); 7.7232 (5.2); 7.6907 (6.2); 7.6733 (9.8); 7.6474 (0.4); 7.5784 (5.4); 7.5498 (9.8); 7.4960 (0.4); 7.4828 (1.8); 7.4742 (1.7); 7.4684 (2.8); 7.4620 (2.3); 7.4524 (1.7); 7.4442 (1.2); 7.3570 (3.3); 7.3504 (3.2); 7.3288 (2.6); 7.3222 (2.6); 7.3016 (31.3); 4.5245 (2.7); 4.5041 (2.6); 4.4761 (5.6); 4.4556 (5.4); 4.4276 (2.8); 4.4073 (2.7); 2.0494 (1.6); 1.5900 (14.3); 1.2943 (0.8); 0.1101 (0.8); 0.0509 (1.0); 0.0400 (31.4); 0.0290 (1.1)
I-479:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2071 (1.6); 9.1912 (3.2); 9.1755 (1.6); 8.6209 (4.7); 8.6154 (4.8); 8.0734 (16.0); 8.0498 (2.9); 8.0435 (2.8); 8.0287 (3.0); 8.0224 (3.0); 7.7567 (1.2); 7.7374 (3.8); 7.7180 (3.8); 7.7033 (4.6); 7.6834 (1.8); 7.6336 (5.1); 7.5613 (3.0); 7.5414 (2.4); 7.5121 (5.0); 7.4912 (4.7); 4.2330 (1.5); 4.2175 (1.6); 4.1991 (3.5); 4.1833 (3.4); 4.1648 (1.8); 4.1488 (1.7); 3.3333 (129.7); 3.3294 (135.2); 2.6762 (0.4); 2.6713 (0.6); 2.6670 (0.5); 2.5418 (11.1); 2.5111 (41.1); 2.5069 (83.7); 2.5025 (111.8); 2.4981 (81.7); 2.3335 (0.4); 2.3292 (0.6); 2.3249 (0.5); -0.0007 (2.9)
I-480:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1570 (1.2); 9.1414 (2.5); 9.1258 (1.2); 7.9847 (12.9); 7.9601 (0.6); 7.5247 (1.8); 7.5049 (4.6); 7.4852 (3.5); 7.4352 (3.8); 7.4159 (2.4); 7.3516 (2.8); 7.3466 (4.4); 7.3428 (3.4); 7.3187 (6.0); 7.2987 (6.0); 7.0839 (4.3); 6.9439 (2.3); 6.9241 (2.1); 4.3170 (10.4); 4.1289 (1.2); 4.1133 (1.2); 4.0919 (2.7); 4.0762 (2.7); 4.0548 (1.4); 4.0391 (1.3); 3.3526 (15.5); 2.8977 (4.2); 2.7391 (3.7); 2.5316 (1.0); 2.5181 (17.8); 2.5139 (34.3); 2.5094 (44.4); 2.5049 (32.6); 2.4205 (11.3); 2.2627 (0.8); 2.2424 (16.0); 2.1938 (0.5)
I-481:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2123 (5.2); 8.0553 (0.6); 8.0285 (0.6); 7.6067 (0.6); 7.5805 (1.6); 7.5542 (1.2); 7.4872 (1.4); 7.4615 (0.9); 7.4164 (1.8); 7.3905 (1.0); 7.3873 (1.1); 7.3834 (0.9); 7.3639 (0.7); 7.3605 (0.8); 7.3566 (0.8); 7.3053 (7.8); 6.8977 (1.1); 6.7100 (2.2); 6.6308 (4.8); 6.5223 (1.1); 5.4060 (0.6); 5.3815 (0.7); 5.3433 (1.7); 4.2006 (0.5); 4.1767 (1.6); 4.1529 (1.6); 4.1291 (0.5); 2.7790 (16.0); 2.6220 (1.4); 2.6084 (1.3); 2.3063 (0.6); 2.2923 (0.5); 2.2793 (0.4); 2.2624 (0.4); 2.0890 (7.3); 1.9604 (0.5); 1.9528 (0.5); 1.9334 (1.2); 1.9258 (1.2); 1.9173 (2.4); 1.9065 (1.4); 1.8970 (1.3); 1.8840 (0.4); 1.8729 (0.4); 1.6190 (2.7); 1.3268 (2.0); 1.3030 (4.3); 1.2792 (1.9); 0.0432 (7.6)
I-482:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2501 (16.0); 8.0114 (1.5); 7.7839 (2.1); 7.4785 (6.0); 7.4570 (12.5); 7.4183 (11.9); 7.3969 (5.8); 7.2863 (2.3); 7.2818 (3.7); 7.2772 (2.7); 7.2594 (35.5); 7.2003 (6.1); 7.1977 (6.2); 6.9605 (2.3); 6.9552 (4.0); 6.9498 (2.3); 6.9388 (2.4); 6.9333 (4.0); 6.9280 (2.2); 4.2064 (2.9); 4.1913 (2.8); 4.1707 (6.0); 4.1555 (5.9); 4.1348 (3.1); 4.1197 (3.0); 2.9531 (10.7); 2.8796 (9.9); 1.5442 (26.6); -0.0002 (2.7)
I-483:1 H-NMR(400.1 MHz, CDCl3): δ= 8.6949 (4.5); 8.6906 (4.8); 8.5257 (4.4); 8.5199 (4.6); 8.2872 (10.0); 8.0175 (2.4); 7.8312 (2.9); 7.8259 (4.8); 7.8206 (3.0); 7.7825 (1.3); 7.5687 (4.7); 7.4334 (1.8); 7.4292 (1.7); 7.4125 (3.1); 7.4082 (3.1); 7.3581 (4.8); 7.3373 (2.8); 7.2602 (24.6); 6.0556 (0.9); 6.0478 (0.9); 6.0371 (1.0); 6.0294 (0.9); 5.9385 (0.9); 5.9309 (1.0); 5.9201 (1.0); 5.9124 (0.9); 4.3079 (0.4); 4.3005 (0.5); 4.2914 (0.5); 4.2834 (0.5); 4.2719 (0.6); 4.2638 (0.6); 4.2547 (0.6); 4.2470 (0.6); 4.2383 (0.5); 4.2306 (0.5); 4.2211 (0.5); 4.2131 (0.5); 4.2016 (0.6); 4.1939 (0.6); 4.1846 (0.6); 4.1767 (0.5); 3.8247 (0.6); 3.8119 (0.6); 3.8063 (0.6); 3.7935 (0.6); 3.7882 (0.5); 3.7744 (0.9); 3.7614 (0.7); 3.7561 (0.9); 3.7428 (0.6); 3.7374 (0.6); 3.7248 (0.5); 3.7187 (0.5); 3.7062 (0.4); 2.9567 (16.0); 2.8832 (14.8); 1.5570 (0.7); -0.0002 (36.1)
I-484:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.6725 (0.7); 8.6589 (1.5); 8.6454 (0.7); 7.9618 (1.6); 7.7027 (0.7); 7.6829 (1.7); 7.6632 (1.3); 7.6254 (1.9); 7.6060 (1.0); 7.5094 (2.3); 7.4750 (1.3); 7.4552 (1.0); 7.0627 (1.8); 7.0576 (1.9); 6.9969 (2.1); 6.9763 (2.2); 6.4811 (2.5); 6.4754 (2.6); 6.1987 (1.4); 6.1928 (1.3); 6.1781 (1.3); 6.1723 (1.3); 3.7871 (0.8); 3.7474 (1.4); 3.7382 (14.1); 3.7143 (0.3); 3.6687 (16.0); 3.4225 (0.7); 3.4057 (1.7); 3.3910 (1.7); 3.3740 (0.8); 3.3159 (19.9); 2.8996 (10.3); 2.7406 (9.3); 2.6934 (1.4); 2.6757 (2.8); 2.6580 (1.6); 2.6397 (0.9); 2.6333 (0.9); 2.6259 (0.7); 2.5141 (8.9); 2.5098 (12.0); 2.5056 (9.1); 0.6570 (6.0); 0.6416 (2.9)
I-485:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5074 (5.7); 7.4901 (7.4); 7.4643 (0.4); 7.4078 (3.8); 7.3780 (0.6); 7.3632 (4.8); 7.3490 (2.5); 7.3426 (2.6); 7.3358 (5.3); 7.2983 (22.5); 7.1836 (1.0); 7.1649 (1.8); 7.1450 (1.0); 7.0606 (4.2); 7.0180 (0.4); 6.9924 (2.3); 6.9650 (2.0); 6.7567 (0.6); 4.2129 (1.4); 4.1939 (1.7); 4.1707 (2.2); 4.1626 (3.2); 4.1467 (2.9); 4.1422 (3.1); 4.1232 (0.8); 4.1120 (1.6); 4.0915 (1.5); 3.5728 (1.4); 3.5511 (3.5); 3.5332 (3.6); 3.5117 (1.4); 2.5602 (2.8); 2.5378 (6.2); 2.5155 (3.5); 2.4850 (11.9); 2.3588 (0.3); 2.3228 (16.0); 2.1317 (0.5); 2.0838 (7.1); 2.0537 (2.8); 2.0316 (3.9); 2.0094 (2.5); 1.9870 (0.7); 1.4701 (5.1); 1.3208 (1.9); 1.2969 (4.1); 1.2787 (1.1); 1.2732 (1.9); 1.2594 (0.3); 0.1195 (1.3); 0.1078 (23.0); 0.0954 (0.9); 0.0483 (1.0); 0.0376 (22.2); 0.0267 (0.8)
I-486:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1408 (0.9); 9.1253 (2.0); 9.1100 (1.0); 8.6214 (5.2); 8.3849 (2.8); 8.3728 (3.1); 8.1920 (6.1); 7.9607 (1.9); 7.7911 (0.6); 7.7715 (2.0); 7.7513 (2.0); 7.7279 (5.7); 7.7153 (4.9); 7.7033 (3.6); 7.6406 (2.0); 7.6207 (1.6); 7.5862 (3.0); 7.5653 (5.8); 7.5227 (5.7); 7.5017 (3.2); 4.1879 (0.9); 4.1728 (1.0); 4.1535 (2.0); 4.1381 (2.0); 4.1197 (1.1); 4.1039 (1.0); 3.9992 (16.0); 3.3257 (97.6); 2.8985 (9.5); 2.7396 (9.1); 2.5092 (14.1)
I-487:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2896 (2.6); 9.2699 (2.7); 8.1889 (16.0); 8.1802 (0.7); 7.9544 (0.4); 7.7592 (1.2); 7.7396 (3.9); 7.7262 (5.5); 7.7206 (6.7); 7.6952 (4.4); 7.6765 (2.0); 7.6447 (3.1); 7.6264 (2.0); 7.6241 (2.0); 7.4741 (5.9); 7.3818 (2.2); 7.3628 (4.8); 7.3440 (3.4); 7.3248 (6.4); 7.3060 (3.5); 7.2901 (3.0); 7.2857 (4.6); 7.2814 (3.1); 7.2707 (1.6); 7.2662 (2.2); 7.2622 (1.4); 5.1752 (0.4); 5.1576 (1.8); 5.1393 (2.7); 5.1212 (1.9); 5.1033 (0.5); 3.4449 (0.3); 3.3975 (70.7); 3.3893 (111.8); 2.8932 (2.5); 2.7348 (2.2); 2.5307 (0.4); 2.5174 (10.1); 2.5130 (21.5); 2.5085 (29.3); 2.5039 (21.3); 2.4995 (10.4); 1.4602 (13.6); 1.4427 (13.7); 1.4263 (0.6); 1.2391 (0.4)
I-488:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.7980 (0.9); 8.7844 (1.7); 8.7708 (0.9); 8.5666 (8.1); 7.9589 (0.5); 7.8006 (0.6); 7.7805 (1.9); 7.7601 (3.5); 7.7519 (5.6); 7.6636 (1.8); 7.6453 (1.3); 7.0555 (2.6); 7.0364 (2.9); 6.9122 (3.5); 6.7717 (1.9); 6.7530 (1.6); 3.5247 (1.2); 3.5078 (2.6); 3.4914 (2.6); 3.4744 (1.2); 3.3195 (19.3); 2.8967 (2.9); 2.8290 (2.2); 2.8110 (3.7); 2.7931 (1.9); 2.7376 (2.6); 2.6762 (0.4); 2.5112 (54.3); 2.5071 (68.3); 2.5031 (50.0); 2.3338 (0.4); 2.2624 (16.0); 2.1605 (14.5)
I-489:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3336 (10.0); 7.7350 (1.0); 7.6500 (0.6); 7.6309 (6.1); 7.6088 (2.6); 7.5826 (0.7); 7.3376 (2.9); 7.3039 (9.0); 7.2957 (1.7); 7.2794 (1.3); 7.2722 (1.8); 7.2643 (0.8); 7.2085 (2.0); 7.1832 (2.1); 7.0314 (0.9); 7.0269 (0.9); 7.0055 (1.9); 7.0030 (2.0); 6.9802 (1.3); 6.9754 (1.2); 6.7923 (1.5); 6.7884 (1.7); 6.7674 (2.3); 6.7636 (2.8); 6.7488 (3.2); 6.7451 (2.8); 6.7388 (1.4); 6.7217 (2.4); 5.3413 (1.1); 4.3261 (0.6); 4.3148 (0.7); 4.3012 (0.6); 4.2892 (1.8); 4.2775 (1.4); 4.2640 (1.5); 4.2526 (1.3); 4.2316 (1.2); 4.2201 (1.4); 4.2074 (1.4); 4.1969 (2.6); 4.1828 (0.7); 4.1737 (3.8); 4.1585 (0.7); 4.1499 (3.6); 4.1261 (1.2); 4.0446 (0.6); 4.0292 (0.7); 4.0221 (0.6); 4.0065 (0.7); 3.9985 (1.4); 3.9831 (1.5); 3.9761 (1.4); 3.9607 (1.4); 3.9324 (1.3); 3.9151 (1.6); 3.9111 (1.6); 3.8939 (1.4); 3.8865 (0.7); 3.8691 (0.7); 3.8649 (0.7); 3.8479 (0.6); 3.3303 (0.3); 3.3097 (1.0); 3.2908 (1.3); 3.2722 (1.0); 2.2192 (0.4); 2.2079 (0.4); 2.1985 (0.5); 2.1944 (0.5); 2.1872 (0.6); 2.1831 (0.5); 2.1730 (0.9); 2.1613 (1.0); 2.1516 (0.8); 2.1477 (0.9); 2.1402 (0.9); 2.1364 (0.8); 2.1272 (0.7); 2.1156 (0.6); 2.0866 (16.0); 2.0457 (0.7); 2.0336 (0.7); 2.0218 (1.1); 2.0105 (1.1); 1.9985 (1.0); 1.9871 (0.9); 1.9750 (0.7); 1.9639 (0.6); 1.9515 (0.4); 1.9401 (0.3); 1.6266 (7.4); 1.3247 (4.3); 1.3008 (8.4); 1.2770 (4.1); 0.0416 (7.6)
I-490:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1801 (1.2); 9.1651 (2.5); 9.1499 (1.2); 8.0103 (9.3); 7.6531 (1.5); 7.6308 (3.1); 7.6109 (1.8); 7.3524 (2.5); 7.3331 (7.3); 7.3022 (5.7); 7.0811 (4.5); 6.9301 (2.5); 6.9107 (2.2); 4.1317 (1.2); 4.1160 (1.2); 4.0946 (2.7); 4.0790 (2.6); 4.0575 (1.4); 4.0418 (1.3); 3.3398 (40.2); 2.6785 (0.3); 2.5094 (57.7); 2.4193 (11.7); 2.3360 (0.4); 2.2609 (0.6); 2.2272 (16.0); 2.1805 (0.5)
I-491:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2404 (16.0); 8.0148 (1.2); 7.7574 (2.1); 7.6479 (7.2); 7.4703 (1.3); 7.4491 (12.8); 7.4212 (1.0); 7.2902 (2.2); 7.2853 (3.5); 7.2808 (2.6); 7.2587 (46.6); 7.2069 (5.8); 7.2049 (5.7); 6.9664 (2.2); 6.9611 (3.9); 6.9557 (2.2); 6.9447 (2.3); 6.9393 (3.9); 6.9339 (2.1); 4.4257 (2.6); 4.4104 (2.5); 4.3894 (5.4); 4.3741 (5.3); 4.3531 (2.8); 4.3378 (2.7); 2.9534 (8.1); 2.8807 (7.4); 1.5340 (47.6); 1.5033 (0.3); 1.2556 (0.4)
I-492:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2444 (16.0); 8.0130 (1.7); 7.8728 (2.1); 7.4803 (6.2); 7.4587 (12.6); 7.4481 (4.7); 7.4413 (4.2); 7.4342 (4.1); 7.4146 (11.3); 7.3932 (5.9); 7.2594 (35.4); 7.2411 (5.4); 7.2214 (4.6); 7.1653 (2.5); 7.1561 (3.5); 7.1485 (2.6); 7.1430 (1.8); 7.1339 (2.1); 7.1261 (1.5); 4.2097 (2.8); 4.1946 (2.8); 4.1739 (5.9); 4.1588 (5.8); 4.1380 (3.0); 4.1229 (2.9); 2.9533 (12.2); 2.8802 (11.3); 1.5445 (26.1); -0.0002 (2.9)
I-493:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0048 (1.3); 8.9907 (2.7); 8.9763 (1.3); 7.9618 (2.6); 7.6958 (1.1); 7.6761 (3.1); 7.6562 (2.4); 7.6214 (3.2); 7.6019 (1.7); 7.5150 (0.7); 7.4781 (4.2); 7.4558 (2.5); 7.4273 (5.0); 7.4058 (6.4); 7.3217 (6.8); 7.3009 (4.7); 7.1240 (3.3); 7.1192 (3.4); 5.7366 (0.7); 5.7228 (1.5); 5.7082 (0.7); 5.6187 (0.7); 5.6043 (1.6); 5.5904 (0.8); 3.7916 (1.2); 3.7776 (2.2); 3.7635 (1.2); 3.7369 (1.3); 3.7230 (2.2); 3.7085 (1.3); 3.3156 (26.0); 2.8995 (16.0); 2.7404 (14.5); 2.6547 (1.2); 2.6460 (1.4); 2.6399 (1.5); 2.6321 (1.2); 2.5140 (14.8); 2.5097 (19.9); 2.5055 (15.0); 0.6871 (4.0); 0.6694 (7.1)
I-494:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1929 (0.4); 9.1816 (0.7); 9.1699 (0.4); 8.8543 (3.5); 8.7183 (1.4); 8.7085 (1.5); 8.2587 (0.4); 8.2392 (3.3); 8.1117 (0.4); 7.9562 (2.3); 7.7545 (1.8); 7.7365 (1.3); 7.7267 (1.2); 7.5402 (0.3); 7.5371 (0.3); 7.5234 (1.3); 7.5204 (1.5); 7.5125 (1.8); 7.4953 (0.8); 7.4759 (0.6); 7.3850 (0.5); 7.3743 (0.5); 7.3707 (0.5); 7.3583 (0.8); 7.3539 (0.9); 7.3446 (0.8); 7.3277 (0.4); 6.0682 (0.4); 6.0654 (0.3); 5.9762 (0.4); 5.9733 (0.4); 3.9087 (0.3); 3.8965 (0.4); 3.3268 (9.5); 2.8933 (16.0); 2.7346 (14.1); 2.5125 (0.8); 2.5091 (1.7); 2.5056 (2.3); 2.5020 (1.7); 2.4986 (0.8); -0.0002 (0.9)
I-495:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.2159 (3.0); 9.1962 (3.1); 8.1712 (16.0); 7.9550 (0.6); 7.7542 (1.3); 7.7348 (3.8); 7.7144 (3.4); 7.6887 (11.2); 7.6698 (2.4); 7.6276 (3.7); 7.6080 (2.3); 7.4609 (4.5); 7.4470 (5.2); 7.4393 (5.8); 7.4306 (2.3); 7.4254 (5.1); 7.1400 (0.6); 7.1323 (5.9); 7.1273 (2.1); 7.1155 (2.3); 7.1101 (10.8); 7.0930 (1.8); 7.0879 (5.4); 7.0803 (0.6); 5.1669 (0.5); 5.1495 (1.9); 5.1313 (2.9); 5.1131 (2.0); 5.0956 (0.5); 3.3675 (39.2); 3.3641 (48.1); 3.3607 (48.9); 3.3574 (53.6); 2.8926 (4.1); 2.7343 (3.6); 2.5290 (0.4); 2.5155 (10.8); 2.5112 (22.9); 2.5066 (31.0); 2.5021 (22.5); 2.4977 (11.0); 1.4550 (15.0); 1.4376 (14.8); 1.2395 (0.4); -0.0002 (0.7)
I-496:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1703 (1.1); 9.1548 (2.4); 9.1391 (1.1); 8.3165 (0.4); 8.0126 (14.8); 7.7672 (1.0); 7.7477 (2.9); 7.7281 (2.8); 7.7114 (3.3); 7.6916 (1.3); 7.6269 (3.8); 7.5676 (2.1); 7.5474 (1.7); 7.4327 (4.0); 7.4126 (4.4); 7.3834 (4.4); 6.9681 (2.3); 6.9482 (2.1); 4.2831 (1.2); 4.2672 (1.2); 4.2479 (2.6); 4.2321 (2.5); 4.2126 (1.3); 4.1969 (1.2); 3.9028 (3.2); 3.3260 (105.2); 2.6755 (0.9); 2.6709 (1.2); 2.6664 (0.9); 2.6618 (0.4); 2.5244 (3.9); 2.5196 (6.2); 2.5110 (79.8); 2.5065 (160.3); 2.5020 (207.7); 2.4974 (147.9); 2.4929 (70.5); 2.3470 (0.4); 2.3379 (0.5); 2.3333 (1.0); 2.3288 (1.3); 2.3242 (0.9); 2.2170 (16.0); -0.0003 (1.1)
I-497:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.3020 (0.8); 9.2896 (1.5); 9.2771 (0.7); 7.7396 (0.7); 7.7238 (1.8); 7.7079 (1.4); 7.6808 (1.8); 7.6651 (1.0); 7.5882 (2.3); 7.5551 (1.3); 7.5393 (1.0); 7.3227 (2.2); 7.3067 (2.3); 7.0951 (2.4); 6.9683 (1.3); 6.9525 (1.2); 4.1651 (0.7); 4.1526 (0.7); 4.1352 (1.5); 4.1227 (1.4); 4.1052 (0.8); 4.0927 (0.7); 3.3213 (3.0); 2.5091 (0.7); 2.5056 (1.3); 2.5020 (1.6); 2.4984 (1.1); 2.4949 (0.5); 2.4323 (6.7); 2.2390 (9.3); 2.2090 (16.0); 0.8563 (0.5)
I-498:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3129 (16.0); 7.9627 (1.7); 7.6825 (6.5); 7.6650 (8.6); 7.5152 (4.6); 7.5002 (0.6); 7.4865 (2.0); 7.4767 (2.4); 7.4709 (2.9); 7.4641 (2.4); 7.4542 (2.6); 7.4493 (3.1); 7.4318 (2.3); 7.4234 (1.8); 7.4054 (1.8); 7.3681 (4.0); 7.3408 (2.1); 7.3037 (11.0); 7.2918 (2.5); 7.2620 (2.3); 7.2153 (1.3); 7.2081 (1.2); 7.1873 (2.2); 7.1806 (1.9); 7.1599 (1.0); 7.1533 (0.9); 4.2849 (2.7); 4.2647 (2.6); 4.2374 (5.6); 4.2171 (5.5); 4.1898 (2.9); 4.1696 (2.8); 4.1493 (0.5); 2.0860 (2.2); 1.6137 (6.3); 1.3243 (0.7); 1.3004 (1.8); 1.2766 (0.7); 0.0415 (9.8); 0.0307 (0.4)
I-499:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9369 (4.0); 8.8035 (3.6); 8.7952 (3.5); 8.3414 (11.1); 7.9213 (3.6); 7.7807 (1.4); 7.3856 (3.4); 7.3590 (4.0); 7.3047 (22.4); 7.0970 (4.0); 7.0230 (2.2); 6.9969 (1.9); 4.3232 (1.9); 4.3036 (1.9); 4.2748 (4.1); 4.2551 (3.9); 4.2263 (2.1); 4.2066 (2.0); 2.5193 (11.7); 2.5122 (6.5); 2.3387 (16.0); 1.6014 (10.8); 1.2990 (0.4); 0.1134 (0.7); 0.0539 (1.0); 0.0433 (21.9); 0.0324 (0.8)
I-500:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.7914 (0.7); 8.7773 (1.4); 8.7630 (0.7); 7.9620 (0.7); 7.7530 (0.6); 7.7333 (1.6); 7.7136 (1.5); 7.6917 (1.9); 7.6720 (0.9); 7.6089 (2.2); 7.5645 (1.3); 7.5448 (1.1); 7.0344 (2.1); 7.0138 (2.3); 6.5184 (2.4); 6.5127 (2.6); 6.2915 (1.4); 6.2856 (1.4); 6.2709 (1.4); 6.2650 (1.3); 3.7695 (14.2); 3.7244 (0.4); 3.6845 (16.0); 3.5142 (0.8); 3.4974 (2.1); 3.4821 (2.2); 3.4658 (0.9); 3.3157 (13.2); 2.8998 (4.4); 2.7479 (1.6); 2.7409 (4.6); 2.7311 (3.1); 2.7141 (1.5); 2.5142 (7.1); 2.5099 (9.6); 2.5057 (7.2); 2.4809 (0.5); 2.2778 (13.1)
I-501:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1974 (1.3); 9.1837 (2.6); 9.1693 (1.5); 8.8607 (7.0); 8.7244 (3.7); 8.7121 (4.0); 8.2447 (7.8); 8.1165 (0.7); 7.9609 (3.4); 7.7412 (3.7); 7.7290 (3.8); 7.6499 (5.1); 7.5965 (3.0); 7.5755 (3.9); 7.5189 (0.6); 7.4992 (1.5); 7.4801 (1.8); 7.4570 (1.0); 7.4182 (3.2); 7.3970 (3.3); 7.3762 (2.0); 7.3580 (3.5); 7.3446 (2.4); 7.3250 (1.0); 6.1072 (0.7); 6.0946 (1.3); 6.0828 (0.9); 5.9919 (0.8); 5.9795 (1.3); 5.9679 (0.9); 3.9981 (0.4); 3.9773 (0.6); 3.9609 (1.1); 3.9425 (0.9); 3.9205 (1.3); 3.9061 (1.9); 3.8623 (0.9); 3.8511 (1.2); 3.8394 (0.8); 3.8289 (0.5); 3.8159 (0.5); 3.8038 (0.4); 3.3256 (135.8); 2.8996 (16.0); 2.7404 (15.0); 2.5105 (20.0); 2.5073 (18.7)
I-502:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1981 (0.9); 9.1783 (0.9); 8.1645 (5.1); 7.9534 (0.3); 7.7531 (0.4); 7.7335 (1.4); 7.7145 (2.8); 7.6915 (1.7); 7.6723 (0.7); 7.6370 (1.1); 7.6174 (0.7); 7.2243 (1.1); 7.2042 (2.3); 7.1838 (1.4); 6.9792 (1.6); 6.9749 (1.6); 6.9694 (2.0); 6.9641 (2.6); 6.8030 (1.0); 6.7981 (1.0); 6.7822 (0.9); 6.7781 (0.9); 5.1263 (0.7); 5.1079 (1.0); 5.0895 (0.7); 3.6584 (16.0); 3.3715 (17.3); 3.3659 (24.3); 3.3634 (24.2); 3.3617 (24.2); 2.8917 (2.2); 2.7337 (2.0); 2.5142 (4.3); 2.5099 (8.9); 2.5054 (11.9); 2.5009 (8.6); 2.4965 (4.2); 1.4519 (5.0); 1.4344 (5.0)
I-503:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5659 (3.1); 7.3904 (0.8); 7.3627 (5.0); 7.3562 (3.9); 7.3510 (3.3); 7.3281 (0.6); 7.3228 (0.6); 7.3051 (1.5); 7.2983 (2.8); 7.2791 (2.6); 7.2527 (1.8); 6.9645 (2.2); 6.9574 (3.6); 6.9303 (3.5); 6.8971 (2.9); 6.8912 (3.5); 6.8849 (2.1); 6.8750 (1.4); 6.8550 (0.8); 6.0437 (0.6); 6.0333 (0.7); 6.0210 (0.7); 6.0106 (0.6); 5.8886 (0.6); 5.8782 (0.7); 5.8659 (0.7); 5.8555 (0.6); 4.1321 (0.4); 4.1215 (0.4); 4.1107 (0.4); 4.0999 (0.5); 4.0932 (0.4); 4.0714 (0.3); 4.0440 (0.4); 4.0334 (0.4); 4.0226 (0.4); 4.0121 (0.4); 3.9071 (0.4); 3.8863 (0.6); 3.8645 (0.4); 3.8587 (0.4); 3.8337 (0.6); 3.8124 (0.7); 3.7897 (0.4); 3.7835 (0.4); 3.7615 (0.5); 3.7407 (0.3); 2.5980 (0.4); 2.5751 (15.8); 2.5617 (1.1); 2.3797 (0.5); 2.2629 (16.0); 2.0295 (4.0); 1.9531 (0.4); 1.9361 (0.7); 1.9250 (0.8); 1.9083 (1.4); 1.8915 (0.8); 1.8804 (0.8); 1.8634 (0.4); 1.0116 (0.9); 0.9963 (2.4); 0.9896 (2.6); 0.9749 (1.5); 0.9681 (2.6); 0.9615 (2.2); 0.9471 (1.0); 0.7379 (1.2); 0.7227 (3.0); 0.7171 (2.8); 0.7065 (2.6); 0.7007 (3.0); 0.6845 (0.8); 0.0358 (2.0)
I-504:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9788 (1.7); 8.9584 (1.7); 7.9601 (1.8); 7.7140 (6.1); 7.6761 (2.1); 7.6563 (2.3); 7.4013 (2.1); 7.3808 (2.5); 7.3113 (4.8); 7.1625 (0.5); 7.1492 (1.4); 7.1420 (3.1); 7.1287 (4.7); 7.1184 (2.0); 7.1133 (1.7); 7.1038 (0.6); 6.9520 (1.3); 6.9332 (2.2); 6.9153 (1.5); 6.9068 (1.3); 6.8960 (1.3); 6.8843 (0.9); 6.8785 (0.7); 5.4782 (0.9); 5.4599 (1.3); 5.4420 (0.9); 3.7363 (16.0); 3.3400 (90.0); 2.8973 (10.7); 2.7385 (9.8); 2.5741 (15.0); 2.5131 (7.2); 2.5092 (9.5); 2.5052 (7.4); 2.0746 (0.6); 2.0661 (0.7); 2.0540 (1.2); 2.0410 (0.8); 2.0331 (0.7); 2.0197 (0.4); 1.6137 (6.1); 1.5967 (6.3); 1.0373 (0.7); 1.0264 (2.2); 1.0212 (2.4); 1.0108 (1.4); 1.0054 (2.3); 1.0003 (2.4); 0.9903 (1.0); 0.7916 (0.9); 0.7771 (2.7); 0.7686 (2.6); 0.7641 (2.7); 0.7527 (0.9)
I-505:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2349 (1.4); 9.2192 (2.8); 9.2036 (1.4); 8.3161 (0.3); 8.0260 (16.0); 8.0169 (0.3); 7.7608 (1.2); 7.7412 (3.5); 7.7217 (3.5); 7.7051 (6.0); 7.6861 (1.8); 7.6774 (2.6); 7.6740 (2.6); 7.6248 (4.7); 7.5534 (2.6); 7.5334 (2.1); 7.4596 (2.0); 7.4390 (4.2); 7.4185 (2.6); 7.2904 (3.0); 7.2866 (2.9); 7.2697 (2.3); 7.2656 (2.3); 4.1990 (1.3); 4.1834 (1.4); 4.1643 (2.9); 4.1484 (2.8); 4.1294 (1.5); 4.1135 (1.4); 3.9030 (3.7); 3.3300 (213.6); 2.6805 (0.4); 2.6761 (0.9); 2.6715 (1.3); 2.6669 (0.9); 2.6625 (0.4); 2.5250 (4.0); 2.5202 (6.2); 2.5116 (80.6); 2.5071 (163.5); 2.5026 (213.5); 2.4980 (152.7); 2.4935 (73.6); 2.3384 (0.4); 2.3339 (0.9); 2.3294 (1.3); 2.3248 (1.0); 2.3203 (0.4); -0.0002 (1.0)
I-506:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5518 (0.3); 7.5356 (2.1); 7.5238 (5.2); 7.3969 (2.5); 7.3413 (0.8); 7.3356 (1.2); 7.3306 (1.2); 7.3236 (1.0); 7.2586 (4.2); 7.0119 (2.1); 6.9966 (2.5); 6.9514 (3.0); 6.8406 (1.6); 6.8254 (1.4); 6.1293 (0.6); 6.1185 (1.1); 6.1077 (0.6); 5.2955 (1.5); 3.7717 (1.2); 3.7588 (3.2); 3.7458 (3.4); 3.7327 (1.3); 2.9355 (2.2); 2.9219 (4.2); 2.9083 (2.0); 2.3853 (16.0); 2.2872 (14.4); 2.2696 (0.6); 2.2426 (13.3); 2.1584 (0.5); 1.5656 (9.3); -0.0002 (2.9)
I-507:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5670 (7.6); 8.0400 (0.7); 8.0206 (1.2); 8.0007 (0.7); 7.8052 (0.7); 7.7374 (2.9); 7.7211 (0.6); 7.6937 (2.0); 7.6726 (5.5); 7.6513 (0.5); 7.5500 (2.6); 7.5331 (0.4); 7.5157 (1.1); 7.5062 (1.7); 7.4989 (1.1); 7.4919 (0.7); 7.4855 (1.2); 7.4774 (0.7); 7.4158 (0.4); 7.3846 (2.7); 7.3579 (3.0); 7.3035 (17.2); 7.0835 (2.8); 6.9927 (1.5); 6.9656 (1.3); 4.3313 (1.2); 4.3116 (1.2); 4.2832 (2.5); 4.2633 (2.4); 4.2350 (1.2); 4.2150 (1.2); 4.1981 (0.7); 4.1743 (1.9); 4.1505 (1.9); 4.1267 (0.7); 4.0874 (16.0); 3.9228 (0.5); 3.9088 (0.8); 2.9986 (1.1); 2.9251 (1.0); 2.6573 (1.3); 2.6347 (0.8); 2.5285 (8.2); 2.3223 (11.3); 2.0868 (8.6); 1.8682 (0.3); 1.7797 (0.6); 1.7681 (0.7); 1.7439 (0.7); 1.7202 (0.8); 1.4553 (0.6); 1.4345 (0.6); 1.3242 (2.6); 1.3004 (5.3); 1.2829 (6.5); 1.2767 (2.8); 0.0512 (0.4); 0.0404 (15.4); 0.0295 (0.6)
I-508:1 H-NMR(400.1 MHz, CDCl3): δ= 8.5877 (5.0); 8.5830 (4.9); 8.4556 (4.8); 8.4499 (4.8); 8.2790 (11.1); 7.7476 (1.4); 7.6595 (3.3); 7.6539 (5.3); 7.6485 (3.1); 7.3357 (3.4); 7.3158 (3.8); 7.2599 (19.9); 7.0516 (4.1); 6.9806 (2.2); 6.9605 (2.0); 4.2551 (1.8); 4.2404 (1.8); 4.2190 (3.8); 4.2042 (3.7); 4.1827 (1.9); 4.1680 (1.8); 2.4724 (11.8); 2.3047 (16.0); 2.0042 (0.3); 1.5535 (6.8); -0.0002 (19.3)
I-509:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8818 (5.6); 7.9452 (0.4); 7.9257 (0.7); 7.9054 (0.4); 7.6876 (1.5); 7.6744 (2.9); 7.6692 (4.5); 7.6658 (3.5); 7.6547 (0.4); 7.6511 (0.4); 7.5432 (1.5); 7.5155 (1.2); 7.4998 (0.4); 7.4871 (3.3); 7.4734 (1.1); 7.4667 (1.1); 7.4557 (2.2); 7.4502 (1.8); 7.4278 (0.7); 7.4219 (0.6); 7.2982 (6.3); 5.3358 (1.1); 4.5093 (0.8); 4.4889 (0.8); 4.4610 (1.8); 4.4405 (1.7); 4.4127 (0.9); 4.3922 (0.9); 4.0953 (0.6); 3.9770 (16.0); 2.4095 (15.3); 2.3940 (0.7); 2.0420 (0.3); 1.5970 (3.9); 0.0366 (4.7)
I-510:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1034 (0.8); 9.0888 (1.7); 9.0741 (0.9); 7.9619 (1.0); 7.7522 (0.7); 7.7326 (2.0); 7.7129 (1.9); 7.6913 (2.4); 7.6721 (1.2); 7.5939 (2.8); 7.5558 (1.6); 7.5363 (1.3); 7.4697 (2.6); 7.4485 (5.1); 7.4081 (5.6); 7.3869 (3.0); 5.8377 (0.5); 5.8258 (0.8); 5.8116 (0.6); 5.7200 (0.5); 5.7083 (0.8); 5.6935 (0.6); 3.9145 (0.5); 3.8984 (0.9); 3.8821 (0.7); 3.8722 (0.5); 3.8604 (1.1); 3.8458 (1.2); 3.8288 (0.6); 3.8132 (0.6); 3.8007 (0.7); 3.7889 (0.5); 3.3155 (14.5); 2.8997 (6.0); 2.7407 (5.4); 2.5141 (8.3); 2.5099 (11.3); 2.5057 (8.7); 2.4648 (0.5); 2.2543 (16.0)
I-511:1 H-NMR(400.1 MHz, CDCl3): δ= 8.6420 (0.7); 8.1529 (4.9); 7.8786 (2.0); 7.8716 (2.1); 7.6431 (2.1); 7.6214 (2.4); 7.5813 (2.2); 7.5686 (3.8); 7.4054 (2.2); 7.3917 (0.9); 7.3816 (1.1); 7.3769 (1.0); 7.3692 (0.8); 7.3630 (0.5); 7.2600 (10.8); 7.2442 (1.4); 7.2370 (1.3); 7.2224 (1.2); 7.2153 (1.2); 4.4585 (0.9); 4.4434 (0.9); 4.4262 (2.0); 4.4112 (1.9); 4.3939 (1.0); 4.3789 (1.0); 3.7548 (16.0); 2.9551 (1.8); 2.8827 (1.8); 2.7191 (14.5); 2.6861 (0.5); 1.5640 (1.3); 1.2613 (0.4); 1.2446 (0.3); 0.0078 (0.5); -0.0002 (13.4)
I-512:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3361 (2.0); 9.3206 (4.4); 9.3044 (2.6); 8.8534 (13.9); 8.7175 (7.4); 8.7051 (8.0); 8.1502 (16.0); 8.0531 (1.7); 7.9607 (2.4); 7.8742 (7.7); 7.7199 (7.1); 7.7076 (7.2); 7.5408 (4.8); 7.5197 (8.7); 7.5038 (3.4); 7.4801 (2.7); 7.4574 (6.3); 7.4365 (3.9); 7.4148 (1.6); 7.3946 (2.5); 7.3900 (2.4); 7.3752 (2.8); 7.3577 (1.6); 7.3175 (2.6); 7.3008 (3.3); 7.2803 (1.8); 7.2412 (0.4); 7.2210 (0.5); 4.3369 (1.7); 4.3206 (2.0); 4.3026 (4.2); 4.2872 (4.2); 4.2689 (2.6); 4.2534 (2.4); 4.2264 (0.4); 3.3585 (0.6); 3.3239 (332.2); 2.8986 (14.0); 2.7394 (12.9); 2.5092 (37.8); 2.5054 (29.5); 1.2442 (0.8)
I-513:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9371 (1.7); 8.9168 (1.8); 7.9600 (1.2); 7.7201 (6.2); 7.4109 (3.4); 7.2784 (2.5); 7.2523 (5.4); 7.1480 (0.6); 7.1279 (2.1); 7.1170 (1.5); 7.1103 (4.2); 7.1000 (1.5); 7.0961 (1.5); 7.0801 (0.6); 6.9535 (1.9); 6.9321 (1.7); 6.9151 (0.8); 6.9073 (0.8); 6.8984 (1.4); 6.8929 (1.3); 6.8790 (0.8); 5.4316 (0.9); 5.4135 (1.3); 5.3958 (1.0); 3.7010 (16.0); 3.3383 (145.5); 2.8976 (7.0); 2.7384 (6.5); 2.5753 (15.4); 2.5130 (12.6); 2.5091 (16.6); 2.5051 (12.8); 2.2148 (13.2); 2.0630 (0.6); 2.0550 (0.8); 2.0424 (1.2); 2.0296 (0.8); 2.0217 (0.7); 2.0087 (0.4); 1.6036 (6.1); 1.5867 (6.2); 1.0317 (0.7); 1.0208 (2.2); 1.0156 (2.4); 0.9998 (2.3); 0.9946 (2.4); 0.9847 (1.0); 0.7814 (0.9); 0.7668 (2.8); 0.7584 (2.7); 0.7539 (2.8); 0.7425 (0.9)
I-514:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1590 (1.8); 9.1434 (3.7); 9.1279 (1.8); 8.0572 (16.0); 7.7653 (1.4); 7.7454 (4.3); 7.7258 (4.3); 7.7098 (5.3); 7.6903 (2.2); 7.6496 (6.0); 7.5764 (3.5); 7.5612 (7.4); 7.5404 (11.7); 7.5016 (11.9); 7.4802 (5.9); 4.1539 (1.8); 4.1384 (1.8); 4.1190 (3.9); 4.1034 (3.8); 4.0843 (2.0); 4.0683 (1.9); 3.3413 (142.0); 3.3360 (122.7); 3.3336 (136.7); 2.6725 (0.6); 2.5427 (3.4); 2.5077 (76.8); 2.5034 (103.7); 2.4992 (78.7); 2.3305 (0.6); 2.2151 (0.6); 0.0000 (2.3)
I-515:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4850 (10.0); 8.2617 (16.0); 8.1042 (0.9); 8.0848 (1.8); 8.0658 (1.0); 7.7032 (0.4); 7.6765 (2.8); 7.6569 (7.4); 7.5461 (3.8); 7.5162 (1.6); 7.5062 (2.2); 7.4986 (1.7); 7.4859 (1.5); 7.4782 (0.9); 7.3955 (3.5); 7.3690 (4.0); 7.3041 (16.8); 7.0865 (4.0); 6.9982 (2.2); 6.9724 (1.9); 4.3470 (1.7); 4.3272 (1.6); 4.2989 (3.6); 4.2792 (3.5); 4.2509 (1.8); 4.2311 (1.7); 2.5362 (11.7); 2.3232 (16.0); 1.6962 (0.3); 1.6708 (0.3); 1.2969 (0.4); 0.0528 (0.6); 0.0421 (14.1); 0.0313 (0.4)
I-516:1 H-NMR(499.9 MHz, CDCl3): δ= 7.6369 (3.0); 7.5640 (0.4); 7.5480 (2.1); 7.5358 (5.3); 7.5269 (0.6); 7.4410 (3.2); 7.4348 (2.8); 7.4248 (3.2); 7.3607 (0.9); 7.3554 (1.4); 7.3502 (1.2); 7.3398 (2.7); 7.3227 (1.5); 7.2603 (4.0); 6.7089 (0.7); 6.6965 (1.4); 6.6841 (0.7); 4.3852 (1.0); 4.3724 (1.0); 4.3562 (2.2); 4.3434 (2.1); 4.3272 (1.1); 4.3144 (1.0); 2.3239 (16.0); 1.5693 (6.9); -0.0002 (3.8)
I-517:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3344 (10.6); 7.6530 (1.7); 7.6296 (7.1); 7.6065 (2.8); 7.5803 (0.8); 7.3041 (8.2); 7.2953 (3.6); 7.2740 (3.2); 7.2681 (3.4); 7.2497 (3.4); 7.2443 (3.6); 7.2359 (1.0); 7.0850 (0.7); 7.0791 (0.7); 7.0613 (1.9); 7.0552 (2.0); 7.0446 (1.7); 7.0381 (2.9); 7.0309 (1.8); 7.0205 (2.5); 7.0152 (2.4); 6.9966 (1.1); 6.9912 (0.9); 6.9706 (2.6); 6.9475 (1.3); 6.9412 (1.0); 5.3411 (0.5); 4.1986 (1.1); 4.1748 (3.5); 4.1510 (3.6); 4.1272 (1.2); 3.9956 (0.5); 3.9808 (0.6); 3.9735 (0.5); 3.9587 (0.7); 3.9497 (1.6); 3.9349 (1.7); 3.9278 (1.7); 3.9129 (1.7); 3.9057 (1.6); 3.8894 (1.9); 3.8845 (1.8); 3.8684 (1.6); 3.8600 (0.6); 3.8436 (0.6); 3.8386 (0.7); 3.8226 (0.6); 3.2700 (1.0); 3.2511 (1.3); 3.2338 (0.9); 2.7853 (0.4); 2.7485 (1.0); 2.7282 (2.4); 2.7074 (2.1); 2.6865 (0.9); 2.0875 (16.0); 2.0604 (0.5); 2.0490 (0.9); 2.0293 (1.0); 2.0196 (1.0); 1.9999 (1.0); 1.9902 (0.8); 1.9712 (0.8); 1.9552 (0.9); 1.9379 (1.0); 1.9106 (0.8); 1.8892 (0.4); 1.8329 (0.6); 1.8035 (2.0); 1.7801 (2.1); 1.7659 (1.6); 1.7501 (1.6); 1.7294 (0.5); 1.6378 (7.4); 1.3256 (4.3); 1.3018 (8.7); 1.2780 (4.1); 0.0427 (6.1)
I-518:1 H-NMR(400.1 MHz, CDCl3): δ= 8.5192 (4.6); 8.5132 (4.5); 8.4184 (4.1); 8.4130 (4.0); 8.2831 (11.8); 7.7769 (0.9); 7.7632 (1.4); 7.4442 (1.7); 7.4384 (2.9); 7.4326 (1.6); 7.4227 (1.7); 7.4168 (2.9); 7.4110 (1.5); 7.3381 (3.5); 7.3182 (3.9); 7.2597 (27.8); 7.0527 (4.0); 6.9956 (0.3); 6.9820 (2.2); 6.9621 (1.9); 5.2983 (0.6); 4.3054 (0.3); 4.2575 (1.9); 4.2427 (1.9); 4.2212 (4.0); 4.2064 (3.8); 4.1848 (2.0); 4.1701 (1.9); 2.4732 (11.7); 2.3048 (16.0); 1.5462 (19.6); 1.4222 (0.4); 1.3363 (0.4); 1.2847 (0.7); 1.2554 (5.8); 0.8804 (0.6); 0.8534 (0.5); 0.8450 (0.5); 0.8349 (0.5); -0.0002 (27.6); -0.0083 (1.2)
I-519:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3088 (12.3); 7.9976 (0.9); 7.9791 (1.6); 7.9597 (0.9); 7.7130 (0.4); 7.6833 (4.0); 7.6777 (3.2); 7.6689 (6.8); 7.6661 (7.9); 7.5463 (3.6); 7.4943 (0.5); 7.4801 (1.6); 7.4670 (2.3); 7.4596 (4.8); 7.4508 (1.9); 7.4413 (1.4); 7.4315 (5.1); 7.4059 (4.5); 7.3303 (2.8); 7.2987 (22.7); 5.3380 (3.7); 4.3104 (2.0); 4.2903 (1.9); 4.2618 (4.2); 4.2416 (4.0); 4.2130 (2.2); 4.1929 (2.0); 3.1635 (9.2); 2.5503 (6.9); 2.5436 (12.3); 2.5362 (7.0); 2.2095 (0.8); 1.5898 (16.0); 1.2921 (0.6); 0.1075 (5.5); 0.0483 (0.9); 0.0374 (21.4); 0.0266 (0.9)
I-520:1 H-NMR(400.1 MHz, CDCl3): δ= 8.1637 (12.7); 7.9439 (2.1); 7.8363 (1.6); 7.5641 (5.1); 7.4208 (0.9); 7.4043 (1.7); 7.3997 (2.3); 7.3878 (3.3); 7.3841 (3.5); 7.3668 (7.4); 7.3432 (4.0); 7.3391 (3.8); 7.3220 (1.5); 7.3180 (1.6); 7.1896 (19.4); 7.0342 (1.2); 7.0285 (1.3); 7.0134 (2.1); 7.0098 (2.3); 6.9927 (1.1); 6.9881 (1.1); 6.9434 (2.2); 6.9383 (2.8); 6.9194 (5.3); 6.9168 (4.7); 6.8988 (2.0); 6.8930 (2.8); 6.8874 (1.3); 4.3607 (2.1); 4.3453 (2.0); 4.3247 (4.4); 4.3093 (4.3); 4.2886 (2.2); 4.2733 (2.1); 2.8831 (16.0); 2.8104 (14.6); 1.4791 (14.4)
I-521:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2349 (16.0); 8.0138 (1.9); 7.9091 (2.2); 7.5303 (6.2); 7.5090 (7.3); 7.4769 (7.4); 7.4679 (3.9); 7.4516 (4.0); 7.4310 (2.1); 7.2594 (36.1); 7.2409 (3.5); 7.2365 (3.3); 7.1041 (1.7); 7.0984 (1.9); 7.0833 (3.2); 7.0780 (3.4); 7.0626 (1.6); 7.0573 (1.6); 7.0157 (3.1); 7.0110 (4.0); 6.9905 (7.2); 6.9853 (4.0); 6.9682 (2.6); 6.9626 (3.8); 6.9571 (1.8); 4.4336 (2.9); 4.4184 (2.9); 4.3977 (6.2); 4.3823 (6.0); 4.3616 (3.2); 4.3462 (3.0); 2.9535 (13.6); 2.8807 (12.8); 1.5463 (24.8); -0.0002 (2.6)
I-522:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6616 (1.2); 7.6354 (7.7); 7.6321 (7.7); 7.6298 (7.8); 7.5973 (1.3); 7.5710 (5.7); 7.5502 (16.0); 7.5332 (1.5); 7.5292 (1.5); 7.5158 (1.8); 7.5114 (2.9); 7.4989 (0.7); 7.4876 (0.5); 7.4713 (0.4); 7.4344 (12.7); 7.4063 (10.5); 7.3765 (0.7); 7.3703 (0.6); 7.3592 (2.8); 7.3500 (5.0); 7.3429 (3.5); 7.3364 (2.0); 7.3281 (3.2); 7.3212 (2.0); 7.2987 (16.9); 7.2926 (6.2); 7.2864 (5.6); 7.2644 (3.8); 7.2583 (3.7); 7.0238 (1.7); 7.0035 (3.1); 6.9837 (1.7); 6.7111 (1.5); 5.3353 (1.3); 4.4043 (3.4); 4.3835 (3.3); 4.3557 (7.2); 4.3349 (6.9); 4.3070 (3.7); 4.2863 (3.5); 3.4540 (0.6); 3.4041 (1.1); 3.3540 (0.6); 2.9945 (0.6); 2.9828 (1.3); 2.9726 (2.1); 2.9603 (2.9); 2.9515 (3.0); 2.9390 (2.2); 2.9289 (1.4); 2.9167 (0.6); 2.2028 (5.6); 2.0100 (1.2); 1.6087 (4.9); 1.2919 (2.0); 0.9164 (0.5); 0.8981 (1.9); 0.8741 (7.5); 0.8568 (7.6); 0.8512 (6.3); 0.8334 (2.5); 0.8040 (0.4); 0.7810 (0.4); 0.7586 (0.4); 0.7461 (0.4); 0.7051 (2.7); 0.6890 (6.8); 0.6814 (8.0); 0.6767 (6.8); 0.6528 (1.7); 0.1077 (3.3); 0.0470 (0.5); 0.0362 (14.4); 0.0252 (0.6)
I-523:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8840 (5.4); 7.9265 (0.4); 7.9069 (0.8); 7.8867 (0.4); 7.6685 (3.1); 7.6588 (3.8); 7.5434 (1.7); 7.5092 (1.3); 7.4808 (3.6); 7.4682 (0.9); 7.4495 (2.1); 7.4444 (1.8); 7.4214 (0.7); 7.4156 (0.6); 7.2984 (2.2); 4.5078 (0.9); 4.4872 (0.9); 4.4596 (1.9); 4.4391 (1.8); 4.4114 (0.9); 4.3909 (0.9); 4.0954 (16.0); 2.3932 (14.8); 2.0370 (1.2); 1.6173 (0.9); 0.0353 (1.7)
I-524:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.8307 (0.7); 8.8166 (1.4); 8.8025 (0.8); 7.7599 (0.5); 7.7402 (1.7); 7.7206 (1.6); 7.7011 (2.0); 7.6813 (1.0); 7.6533 (2.3); 7.5903 (1.3); 7.5701 (1.1); 7.0381 (2.1); 7.0175 (2.3); 6.5132 (2.5); 6.5075 (2.6); 6.2638 (1.4); 6.2579 (1.4); 6.2432 (1.4); 6.2373 (1.3); 3.7666 (14.2); 3.7260 (0.4); 3.6790 (16.0); 3.5833 (1.7); 3.5657 (3.7); 3.5482 (2.0); 3.5203 (0.9); 3.5038 (2.1); 3.4885 (2.2); 3.4719 (1.0); 3.3156 (15.7); 3.2539 (17.1); 3.2309 (0.4); 3.2157 (0.4); 2.9598 (1.5); 2.9424 (2.9); 2.9248 (1.5); 2.8998 (1.8); 2.7494 (1.5); 2.7409 (2.2); 2.7323 (3.1); 2.7150 (1.5); 2.5143 (7.8); 2.5100 (10.4); 2.5057 (8.0)
I-525:1 H-NMR(400.1 MHz, CDCl3): δ= 8.7854 (0.6); 8.1731 (1.9); 8.1327 (5.4); 7.7060 (1.0); 7.6863 (1.1); 7.5883 (3.4); 7.5754 (3.3); 7.4322 (2.0); 7.3687 (0.7); 7.3625 (0.8); 7.3558 (1.1); 7.3510 (1.0); 7.3462 (0.7); 7.3400 (0.5); 7.2775 (1.8); 7.2600 (11.8); 6.6482 (1.1); 6.5086 (2.3); 6.3691 (1.1); 4.0124 (1.1); 3.9980 (2.4); 3.9828 (2.4); 3.9683 (1.1); 3.1975 (1.5); 3.1827 (2.2); 3.1679 (1.4); 2.7146 (16.0); 1.5679 (2.1); 0.0078 (0.6); -0.0002 (13.5); -0.0083 (0.5)
I-526:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3373 (1.5); 9.3213 (3.6); 9.3055 (2.0); 8.8533 (11.6); 8.7172 (6.2); 8.7048 (6.7); 8.1542 (13.8); 8.0532 (1.5); 7.9605 (2.6); 7.7660 (5.4); 7.7617 (5.9); 7.7203 (5.9); 7.7080 (6.0); 7.6191 (4.9); 7.5978 (5.8); 7.5838 (1.0); 7.5206 (0.8); 7.4996 (1.8); 7.4783 (2.1); 7.4590 (1.3); 7.4088 (0.9); 7.3924 (1.9); 7.3877 (1.9); 7.3730 (2.2); 7.3561 (1.2); 7.3326 (3.3); 7.3278 (3.5); 7.3121 (4.5); 7.3063 (4.2); 7.3004 (3.3); 7.2797 (1.6); 7.2403 (0.3); 7.2208 (0.4); 4.3417 (1.5); 4.3260 (1.6); 4.3076 (3.4); 4.2919 (3.4); 4.2735 (2.1); 4.2579 (1.9); 4.2277 (0.3); 3.3234 (260.8); 2.8988 (16.0); 2.7396 (14.6); 2.5136 (19.7); 2.5094 (27.2); 2.5052 (21.2)
I-527:1 H-NMR(400.1 MHz, CDCl3): δ= 8.3357 (2.7); 8.2516 (6.1); 8.2487 (5.0); 7.6672 (0.3); 7.6451 (3.6); 7.6329 (6.2); 7.5445 (4.0); 7.4869 (2.0); 7.4841 (2.0); 7.4741 (1.5); 7.4249 (4.4); 7.4051 (5.5); 7.2588 (9.1); 7.2561 (7.6); 7.2359 (5.3); 7.2166 (4.6); 5.1046 (3.7); 5.0875 (7.5); 5.0561 (7.5); 5.0390 (4.0); 2.3584 (16.0); 2.0882 (1.0); 2.0001 (1.4); 1.6984 (0.6); 1.2562 (0.6); -0.0002 (9.5); -0.0029 (8.0)
I-528:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0029 (1.8); 8.9823 (1.9); 7.9600 (2.2); 7.7118 (6.3); 7.6694 (2.8); 7.6482 (3.1); 7.5275 (3.5); 7.5236 (3.5); 7.3560 (5.0); 7.1586 (0.6); 7.1382 (2.2); 7.1281 (1.5); 7.1209 (4.3); 7.1114 (1.6); 7.1073 (1.6); 7.0914 (0.6); 6.9135 (2.6); 6.9094 (2.5); 6.9044 (1.8); 6.8927 (2.3); 6.8880 (2.4); 5.4569 (0.9); 5.4387 (1.3); 5.4206 (1.0); 3.7302 (16.0); 3.3390 (98.6); 2.8974 (12.7); 2.7384 (11.7); 2.5750 (15.5); 2.5092 (11.4); 2.5053 (8.8); 2.0697 (0.6); 2.0615 (0.7); 2.0490 (1.3); 2.0363 (0.8); 2.0278 (0.7); 2.0150 (0.4); 1.5980 (6.1); 1.5809 (6.2); 1.0360 (0.7); 1.0251 (2.3); 1.0201 (2.5); 1.0041 (2.4); 0.9991 (2.5); 0.9892 (1.0); 0.7912 (0.9); 0.7772 (2.8); 0.7684 (2.8); 0.7641 (2.8); 0.7528 (0.9)
I-529:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3209 (16.0); 7.9794 (1.7); 7.6817 (6.8); 7.6644 (9.2); 7.6506 (0.6); 7.5199 (4.7); 7.4999 (3.8); 7.4862 (2.1); 7.4779 (5.4); 7.4737 (5.8); 7.4654 (2.0); 7.4570 (1.2); 7.3827 (1.1); 7.3581 (3.0); 7.3336 (2.6); 7.3047 (13.7); 7.2885 (4.0); 7.2634 (2.1); 7.2239 (2.0); 7.1988 (2.9); 7.1736 (1.2); 5.3430 (0.4); 4.3324 (2.7); 4.3125 (2.6); 4.2839 (5.6); 4.2640 (5.4); 4.2354 (2.8); 4.2155 (2.7); 4.1762 (0.4); 4.1523 (0.4); 2.5729 (8.3); 2.5656 (15.3); 2.5580 (8.4); 2.2147 (0.5); 2.0888 (1.8); 1.6077 (12.6); 1.3268 (0.6); 1.3029 (1.4); 1.2791 (0.5); 0.0546 (0.5); 0.0438 (13.0); 0.0329 (0.4)
I-530:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2281 (12.8); 8.0140 (2.2); 7.7901 (1.8); 7.6333 (5.7); 7.5188 (0.3); 7.4713 (3.3); 7.4501 (7.4); 7.4201 (4.3); 7.4164 (4.1); 7.3988 (1.9); 7.3952 (1.8); 7.2593 (20.9); 7.2297 (3.5); 7.2197 (2.8); 7.2124 (5.8); 7.1979 (4.5); 7.1902 (1.9); 7.1751 (0.5); 7.1501 (1.2); 7.1460 (1.3); 7.1369 (2.4); 7.1299 (2.2); 7.1221 (1.5); 7.1149 (1.2); 4.4466 (2.2); 4.4311 (2.2); 4.4111 (4.8); 4.3956 (4.7); 4.3756 (2.5); 4.3601 (2.4); 2.9532 (16.0); 2.8804 (15.0); 1.5465 (20.9)
I-531:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2279 (14.6); 8.0134 (2.1); 7.7951 (1.8); 7.5435 (5.1); 7.5223 (6.0); 7.5015 (0.3); 7.4758 (5.6); 7.2677 (3.7); 7.2598 (29.0); 7.2469 (3.1); 7.2420 (3.1); 7.2286 (3.6); 7.2191 (2.8); 7.2109 (6.5); 7.1966 (4.6); 7.1893 (2.2); 7.1744 (0.5); 7.1618 (0.4); 7.1526 (1.3); 7.1484 (1.4); 7.1397 (2.5); 7.1322 (2.3); 7.1239 (1.6); 7.1170 (1.2); 7.1123 (0.9); 7.1080 (0.8); 4.4495 (2.4); 4.4341 (2.4); 4.4141 (5.2); 4.3986 (5.1); 4.3785 (2.7); 4.3630 (2.6); 2.9536 (16.0); 2.8803 (14.6); 1.5510 (17.0); 1.2556 (0.5); -0.0002 (2.2)
I-532:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2978 (1.1); 9.2826 (2.4); 9.2669 (1.4); 8.8551 (8.2); 8.7192 (4.2); 8.7069 (4.5); 8.1910 (8.9); 8.0839 (0.9); 7.9606 (2.8); 7.7262 (4.0); 7.7139 (4.1); 7.6132 (4.1); 7.5922 (7.3); 7.5363 (7.0); 7.5153 (4.8); 7.5012 (2.1); 7.4776 (1.7); 7.4562 (1.0); 7.4080 (0.7); 7.3909 (1.4); 7.3868 (1.4); 7.3721 (1.6); 7.3539 (1.0); 7.3197 (1.6); 7.3029 (1.9); 7.2827 (1.0); 4.1906 (1.1); 4.1753 (1.2); 4.1562 (2.4); 4.1408 (2.5); 4.1219 (1.5); 4.1061 (1.4); 3.3258 (158.2); 2.8987 (16.0); 2.7395 (15.0); 2.5095 (20.3); 1.2448 (0.4)
I-533:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4619 (1.7); 7.4341 (4.0); 7.3769 (1.1); 7.3497 (2.3); 7.3222 (1.4); 7.2992 (11.9); 7.2433 (1.4); 7.2363 (1.2); 7.2154 (1.0); 7.2086 (1.0); 6.8639 (0.9); 6.8560 (1.1); 6.8359 (0.8); 6.8281 (0.9); 6.8074 (0.9); 6.8022 (1.1); 6.7804 (0.7); 6.7756 (1.2); 6.7616 (1.7); 6.7540 (2.2); 6.7465 (1.0); 6.5795 (0.4); 6.5592 (0.7); 6.5388 (0.4); 6.0854 (0.4); 6.0753 (0.4); 6.0627 (0.4); 6.0524 (0.4); 5.9306 (0.4); 5.9202 (0.4); 5.9080 (0.4); 5.8975 (0.4); 5.3379 (1.5); 4.1928 (0.5); 4.1692 (0.8); 4.1449 (0.8); 4.1216 (0.4); 4.1162 (0.4); 4.1052 (0.3); 4.1002 (0.4); 4.0943 (0.4); 3.9415 (0.4); 3.9215 (0.3); 3.8889 (0.4); 3.8687 (0.5); 3.8328 (16.0); 2.4229 (14.3); 2.0819 (3.6); 1.5991 (11.5); 1.3204 (0.8); 1.2965 (1.7); 1.2727 (0.7); 0.9728 (0.5); 0.1073 (4.4); 0.0486 (0.5); 0.0377 (11.6); 0.0271 (0.4)
I-534:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5594 (0.3); 7.5383 (2.4); 7.5331 (2.0); 7.5264 (4.0); 7.5245 (4.3); 7.4822 (2.8); 7.4608 (4.0); 7.4145 (2.2); 7.3767 (4.0); 7.3553 (2.9); 7.3441 (1.0); 7.3410 (1.2); 7.3360 (1.2); 7.3282 (0.9); 7.3218 (0.6); 7.2602 (5.7); 6.6676 (0.6); 6.6522 (1.1); 6.6372 (0.6); 5.2974 (1.0); 4.1829 (1.0); 4.1671 (1.0); 4.1471 (2.1); 4.1313 (2.0); 4.1112 (1.0); 4.0954 (1.0); 2.3091 (16.0); 1.5652 (4.4); -0.0002 (5.2)
I-535:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2387 (16.0); 8.0127 (1.9); 7.7783 (1.3); 7.7653 (2.2); 7.5406 (5.7); 7.5193 (7.0); 7.4935 (6.2); 7.4909 (6.4); 7.2972 (4.0); 7.2922 (4.3); 7.2847 (4.1); 7.2765 (4.3); 7.2705 (5.1); 7.2595 (36.2); 7.2064 (5.9); 7.2043 (5.8); 6.9668 (2.3); 6.9614 (4.0); 6.9560 (2.1); 6.9451 (2.4); 6.9396 (4.0); 6.9342 (2.0); 4.4285 (2.7); 4.4132 (2.7); 4.3922 (5.7); 4.3769 (5.5); 4.3559 (2.9); 4.3405 (2.8); 2.9536 (13.4); 2.8803 (12.5); 1.5456 (25.2); -0.0002 (2.7)
I-536:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9333 (1.6); 8.9188 (3.4); 8.9040 (1.8); 7.9612 (2.4); 7.7050 (13.8); 7.6504 (5.9); 7.5609 (5.4); 7.5398 (7.0); 7.3942 (3.9); 7.3891 (3.9); 7.3732 (3.2); 7.3681 (3.2); 7.3342 (3.0); 7.3145 (6.4); 7.2948 (3.8); 6.9909 (3.8); 6.9714 (3.5); 6.9514 (2.9); 6.9472 (3.5); 6.9313 (2.4); 6.9272 (3.4); 6.9018 (4.8); 6.8974 (6.3); 6.0526 (1.1); 6.0399 (2.3); 6.0272 (1.2); 5.9370 (1.1); 5.9245 (2.2); 5.9116 (1.2); 3.8783 (2.0); 3.8645 (3.7); 3.8505 (2.3); 3.8208 (1.8); 3.8075 (3.5); 3.7932 (2.2); 3.3144 (181.7); 2.8993 (16.0); 2.7405 (14.3); 2.5927 (34.7); 2.5494 (0.5); 2.5138 (18.3); 2.5094 (25.2); 2.5050 (19.0); 2.4310 (0.4); 1.9950 (0.7); 1.9820 (1.4); 1.9736 (1.6); 1.9613 (3.0); 1.9489 (1.8); 1.9404 (1.7); 1.9278 (0.9); 1.0008 (1.7); 0.9899 (5.0); 0.9845 (5.5); 0.9741 (2.8); 0.9689 (5.4); 0.9636 (5.4); 0.9533 (2.2); 0.9366 (0.4); 0.7059 (2.0); 0.6952 (5.8); 0.6904 (6.0); 0.6830 (5.7); 0.6780 (6.4); 0.6667 (2.0)
I-537:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2145 (1.1); 9.1996 (2.2); 9.1838 (1.2); 8.6068 (4.3); 8.5742 (2.4); 8.5622 (2.5); 8.0196 (6.4); 7.9606 (3.4); 7.8708 (4.3); 7.7953 (0.8); 7.7756 (2.3); 7.7559 (2.1); 7.7308 (3.0); 7.7116 (1.6); 7.6915 (3.7); 7.6232 (2.2); 7.6039 (1.8); 7.5252 (2.3); 7.5038 (3.5); 7.4940 (3.1); 7.4815 (2.9); 7.4101 (2.6); 7.3889 (1.9); 4.3331 (0.9); 4.3173 (1.1); 4.2990 (2.1); 4.2833 (2.1); 4.2647 (1.2); 4.2493 (1.1); 3.3221 (116.4); 2.8978 (16.0); 2.7386 (15.2); 2.5118 (16.7); 2.5082 (17.9); 2.3393 (15.2); 1.2448 (0.3)
I-538:1 H-NMR(400.0 MHz, CD3CN): δ= 8.0071 (16.0); 7.8600 (1.1); 7.7436 (5.4); 7.7393 (5.4); 7.7306 (3.8); 7.7109 (4.6); 7.7031 (4.9); 7.6834 (1.4); 7.5939 (4.7); 7.5449 (2.6); 7.5239 (8.6); 7.5014 (6.6); 7.4967 (5.6); 7.4803 (1.6); 7.4754 (1.6); 4.2095 (2.8); 4.1931 (2.8); 4.1761 (5.9); 4.1597 (5.8); 4.1427 (3.0); 4.1264 (2.9); 2.2793 (86.3); 2.2771 (89.0); 2.2691 (109.4); 2.2580 (201.4); 2.1372 (0.4); 1.9943 (4.5); 1.9881 (3.9); 1.9823 (22.0); 1.9762 (40.2); 1.9700 (54.1); 1.9638 (37.0); 1.9576 (19.0); 1.7984 (0.3)
I-539:1 H-NMR(300.2 MHz, CDCl3): δ= 10.2628 (1.6); 10.2431 (1.6); 8.4329 (14.0); 8.2334 (4.5); 8.2052 (4.8); 7.8589 (2.5); 7.8549 (2.2); 7.8503 (1.8); 7.8343 (3.4); 7.8276 (3.1); 7.7971 (4.1); 7.7346 (6.5); 7.7314 (5.9); 7.7224 (4.0); 7.7147 (5.9); 7.6882 (0.9); 7.6754 (0.6); 7.6640 (2.2); 7.6559 (2.3); 7.6445 (2.2); 7.6385 (1.7); 7.6327 (1.1); 7.6250 (0.9); 7.6130 (0.8); 7.6073 (1.0); 7.5900 (2.6); 7.5841 (2.3); 7.5655 (4.8); 7.5612 (4.8); 7.5579 (3.8); 7.5430 (2.4); 7.5376 (3.0); 7.5199 (1.2); 7.5146 (0.8); 7.4490 (3.2); 7.4435 (3.2); 7.4330 (6.6); 7.4190 (2.4); 7.4048 (6.0); 7.3051 (10.1); 5.5500 (0.6); 5.5280 (2.3); 5.5065 (3.4); 5.4850 (2.4); 5.4629 (0.6); 4.1773 (0.4); 4.1535 (0.4); 2.0899 (1.9); 1.7617 (16.0); 1.7394 (15.9); 1.6418 (1.7); 1.3271 (0.6); 1.3032 (1.3); 1.2794 (0.6); 0.0544 (0.4); 0.0436 (9.8); 0.0327 (0.4)
I-540:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2330 (12.8); 8.0134 (2.1); 7.8699 (0.9); 7.8558 (1.6); 7.8423 (0.9); 7.5447 (4.4); 7.5234 (5.2); 7.4856 (4.8); 7.4609 (2.9); 7.4537 (3.2); 7.4470 (3.0); 7.4399 (3.0); 7.2938 (2.8); 7.2890 (2.8); 7.2724 (2.7); 7.2669 (4.9); 7.2597 (29.4); 7.2445 (4.1); 7.2249 (3.5); 7.1739 (2.0); 7.1644 (2.6); 7.1570 (2.0); 7.1515 (1.4); 7.1421 (1.6); 7.1346 (1.1); 4.4307 (2.1); 4.4154 (2.0); 4.3944 (4.3); 4.3791 (4.2); 4.3579 (2.2); 4.3427 (2.1); 2.9536 (16.0); 2.8804 (14.6); 1.5491 (15.0); -0.0002 (2.4)
I-541:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.7379 (1.0); 8.7241 (1.9); 8.7100 (1.0); 8.0791 (9.8); 7.9535 (0.4); 7.7539 (0.7); 7.7335 (2.4); 7.7136 (2.5); 7.6968 (3.1); 7.6838 (4.1); 7.5939 (2.0); 7.5740 (1.5); 6.8315 (5.4); 6.6811 (12.0); 6.6622 (0.3); 5.8895 (16.0); 3.5257 (1.2); 3.5089 (3.3); 3.4935 (3.4); 3.4769 (1.4); 3.3483 (22.6); 3.3430 (30.4); 3.3400 (28.2); 2.8919 (2.3); 2.7722 (2.5); 2.7549 (5.1); 2.7337 (3.1); 2.5131 (7.8); 2.5090 (15.9); 2.5046 (21.1); 2.5001 (15.4); 1.2390 (0.6); -0.0002 (1.6)
I-542:1 H-NMR(300.1 MHz, MeOD): δ= 8.8316 (2.4); 8.8155 (2.6); 8.2526 (4.2); 8.2314 (3.9); 8.0036 (16.0); 7.8268 (6.8); 7.7990 (8.6); 7.6508 (1.1); 7.6249 (3.2); 7.5986 (3.0); 7.5620 (11.1); 7.5342 (8.8); 7.5216 (4.8); 7.4852 (2.6); 7.4573 (1.8); 5.4981 (0.4); 4.9604 (17.5); 3.8268 (3.2); 3.8040 (7.2); 3.7813 (3.6); 3.3394 (1.8); 3.3340 (3.4); 3.3286 (4.7); 3.3232 (3.3); 3.3179 (1.7); 3.1089 (3.4); 3.0863 (6.8); 3.0635 (3.0); 3.0052 (0.8); 2.8719 (0.7)
I-543:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0945 (4.9); 8.0166 (0.6); 7.8239 (0.6); 7.5498 (3.3); 7.5324 (1.5); 7.5127 (0.5); 7.2719 (1.3); 7.2686 (1.4); 7.2605 (10.7); 7.2529 (1.7); 7.2496 (1.6); 7.2142 (2.1); 7.2099 (1.9); 7.1903 (0.8); 7.1852 (1.1); 7.1796 (0.5); 7.1152 (0.8); 7.0997 (2.2); 7.0875 (2.3); 7.0684 (2.2); 7.0495 (0.7); 4.0086 (0.9); 3.9927 (2.3); 3.9771 (2.2); 3.9617 (1.0); 3.3158 (1.8); 3.2993 (3.0); 3.2830 (1.6); 2.9543 (4.9); 2.8822 (4.5); 2.7751 (0.6); 2.7216 (0.4); 2.6975 (14.4); 2.5238 (0.6); 2.4628 (16.0); 1.5895 (3.6); 0.0078 (0.5); -0.0002 (13.2); -0.0083 (0.5)
I-544:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.9888 (1.3); 8.9744 (2.6); 8.9595 (1.4); 7.9612 (2.5); 7.7481 (10.7); 7.6499 (4.6); 7.5765 (4.2); 7.5555 (5.4); 7.4143 (3.0); 7.4093 (3.0); 7.3934 (2.5); 7.3883 (2.5); 7.1881 (0.9); 7.1676 (3.7); 7.1586 (2.4); 7.1506 (7.2); 7.1419 (2.4); 7.1373 (2.6); 7.1219 (1.0); 7.1172 (0.7); 6.9425 (1.2); 6.9344 (1.2); 6.9262 (2.2); 6.9200 (2.1); 6.9072 (1.4); 6.9024 (1.2); 6.0788 (0.9); 6.0675 (1.2); 6.0527 (1.0); 5.9628 (0.8); 5.9518 (1.2); 5.9483 (1.2); 5.9373 (1.0); 3.9345 (0.4); 3.9142 (0.8); 3.8984 (1.5); 3.8757 (1.3); 3.8609 (1.4); 3.8436 (1.5); 3.8278 (1.6); 3.8144 (1.2); 3.8033 (0.8); 3.7920 (0.4); 3.7784 (0.4); 3.3145 (140.5); 2.8992 (16.0); 2.7403 (14.4); 2.5966 (26.6); 2.5474 (0.4); 2.5137 (14.7); 2.5094 (20.0); 2.5050 (15.0); 2.1023 (0.4); 2.0889 (1.0); 2.0808 (1.2); 2.0683 (2.0); 2.0557 (1.3); 2.0472 (1.2); 2.0345 (0.6); 1.0459 (1.2); 1.0349 (3.6); 1.0295 (4.0); 1.0192 (2.2); 1.0138 (3.9); 1.0085 (4.0); 0.9984 (1.7); 0.9821 (0.4); 0.8021 (1.5); 0.7916 (4.2); 0.7871 (4.5); 0.7790 (4.3); 0.7742 (4.6); 0.7628 (1.5)
I-545:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0983 (1.0); 9.0841 (2.1); 9.0699 (1.2); 8.6138 (4.1); 8.5809 (2.4); 8.5691 (2.5); 8.1246 (0.4); 8.1051 (5.9); 7.9610 (3.5); 7.7933 (0.8); 7.7738 (2.5); 7.7530 (6.7); 7.7371 (4.6); 7.7096 (2.0); 7.6618 (2.3); 7.6429 (1.9); 7.5178 (3.0); 7.5024 (10.2); 6.0829 (0.6); 6.0701 (1.3); 6.0583 (0.7); 5.9672 (0.6); 5.9551 (1.3); 5.9434 (0.8); 3.9390 (1.1); 3.9263 (2.1); 3.9131 (1.4); 3.8828 (1.2); 3.8689 (2.1); 3.8568 (1.3); 3.3266 (98.6); 2.9832 (0.4); 2.9002 (15.7); 2.7408 (15.1); 2.5113 (19.6); 2.5075 (19.3); 2.3573 (16.0)
I-546:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6266 (3.6); 7.6246 (3.6); 7.6030 (1.4); 7.5893 (4.5); 7.5871 (4.7); 7.5818 (3.5); 7.4760 (1.5); 7.4503 (0.7); 7.4387 (0.9); 7.4319 (0.7); 7.4206 (0.6); 7.4123 (0.4); 7.3448 (1.4); 7.3182 (1.6); 7.2986 (8.1); 7.0478 (1.6); 6.9390 (0.9); 6.9127 (0.8); 6.6787 (0.4); 6.6591 (0.8); 6.6386 (0.4); 4.1682 (0.7); 4.1476 (0.7); 4.1196 (1.6); 4.0989 (1.5); 4.0710 (0.8); 4.0504 (0.8); 3.8587 (16.0); 2.4739 (4.8); 2.4669 (2.7); 2.2904 (6.3); 1.6088 (3.2); 1.2941 (0.4); 0.1090 (0.5); 0.0387 (8.0)
I-547:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1125 (2.3); 9.0923 (2.3); 7.7190 (0.8); 7.6994 (2.3); 7.6762 (4.5); 7.6537 (1.5); 7.6149 (2.5); 7.6082 (2.9); 7.5938 (2.8); 7.5871 (3.1); 7.5124 (8.1); 7.4984 (6.8); 7.3666 (4.7); 7.3604 (5.4); 6.8030 (2.6); 6.7822 (2.6); 5.4488 (1.3); 5.4320 (1.9); 5.4176 (1.4); 3.7162 (14.1); 3.7096 (16.0); 3.3438 (77.7); 3.3366 (88.4); 2.9026 (0.4); 2.8954 (0.5); 2.7358 (0.4); 2.5101 (18.4); 2.3412 (13.8); 2.3346 (15.6); 1.5990 (7.6); 1.5885 (7.1); 1.5825 (7.4)
I-548:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3140 (16.0); 7.9589 (1.3); 7.9389 (2.0); 7.7928 (3.1); 7.7894 (3.1); 7.7661 (3.4); 7.7187 (0.4); 7.6904 (6.6); 7.6727 (9.4); 7.6490 (0.9); 7.6335 (3.6); 7.6286 (3.2); 7.6070 (4.3); 7.6022 (3.9); 7.5911 (1.2); 7.5194 (4.9); 7.5039 (0.8); 7.4898 (2.0); 7.4750 (3.0); 7.4682 (2.3); 7.4589 (1.8); 7.4506 (1.2); 7.3036 (115.6); 7.2108 (3.0); 7.1845 (5.3); 7.1579 (2.4); 6.9527 (0.6); 5.3437 (5.9); 4.5370 (2.6); 4.5168 (2.6); 4.4885 (5.6); 4.4680 (5.4); 4.4400 (3.0); 4.4195 (2.8); 2.0891 (0.9); 1.5878 (86.1); 1.4703 (0.6); 1.2974 (3.8); 0.9247 (1.2); 0.9017 (0.6); 0.8781 (0.4); 0.2378 (0.6); 0.1240 (1.8); 0.1118 (53.6); 0.0996 (2.0); 0.0880 (0.5); 0.0531 (4.0); 0.0425 (119.0); 0.0315 (4.1); -0.0869 (0.4); -0.1558 (0.5)
I-549:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5204 (2.5); 7.5164 (2.0); 7.5074 (4.4); 7.4192 (2.2); 7.3846 (0.3); 7.3740 (0.9); 7.3644 (1.3); 7.3596 (1.3); 7.3508 (1.2); 7.3391 (2.8); 7.3126 (2.1); 7.3067 (1.8); 7.2871 (2.0); 7.2684 (1.2); 7.2595 (5.3); 7.2366 (0.7); 6.6356 (0.6); 6.6208 (1.1); 6.6059 (0.6); 5.2960 (0.6); 4.1838 (1.0); 4.1681 (1.0); 4.1476 (2.1); 4.1319 (2.0); 4.1113 (1.0); 4.0957 (1.0); 2.3803 (0.4); 2.3531 (12.2); 2.3088 (16.0); 1.5735 (5.8); 1.2559 (0.4); -0.0002 (3.4)
I-550:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7872 (1.5); 8.7818 (1.6); 8.7708 (1.6); 8.7655 (1.6); 8.6824 (1.9); 8.6763 (1.9); 7.8437 (0.8); 7.8372 (1.1); 7.8305 (0.8); 7.8173 (0.9); 7.8109 (1.3); 7.8043 (0.9); 7.6230 (1.4); 7.6015 (4.5); 7.5807 (0.4); 7.5355 (2.1); 7.5024 (2.2); 7.4871 (1.7); 7.4791 (1.9); 7.4625 (1.0); 7.2988 (25.7); 7.2182 (1.8); 7.1916 (2.1); 7.0309 (2.2); 7.0009 (1.1); 6.9924 (1.2); 6.9548 (1.2); 6.9267 (1.0); 6.4327 (0.5); 6.4136 (1.0); 6.3950 (0.5); 4.0342 (0.7); 4.0136 (0.7); 3.9850 (1.4); 3.9644 (1.4); 3.9361 (0.7); 3.9153 (0.7); 3.6590 (5.9); 2.3950 (6.3); 2.3658 (0.4); 2.3006 (8.4); 2.2079 (0.4); 1.6092 (16.0); 1.2922 (0.4); 0.0482 (0.9); 0.0374 (25.0); 0.0265 (0.9)
I-551:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.7488 (1.5); 8.7351 (3.0); 8.7210 (1.5); 8.0763 (16.0); 7.7599 (1.1); 7.7409 (3.3); 7.7202 (3.6); 7.7035 (10.8); 7.6855 (1.9); 7.6058 (3.4); 7.5864 (2.3); 7.0880 (5.7); 6.9467 (2.8); 6.9435 (2.8); 6.9266 (3.1); 6.9233 (3.0); 6.5555 (6.2); 6.5353 (5.6); 4.4352 (5.2); 4.4134 (10.9); 4.3917 (5.6); 3.5118 (1.9); 3.4947 (5.0); 3.4795 (5.1); 3.4626 (2.1); 3.3411 (85.0); 3.0177 (3.7); 2.9960 (7.2); 2.9743 (3.5); 2.8911 (0.6); 2.7685 (3.7); 2.7510 (7.5); 2.7332 (3.9); 2.5258 (0.6); 2.5123 (14.6); 2.5081 (30.3); 2.5036 (40.4); 2.4991 (29.2); 2.4948 (14.3); 1.2389 (1.2); -0.0002 (4.6)
I-552:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5103 (11.0); 8.4735 (0.4); 7.9923 (2.8); 7.7100 (1.3); 7.6837 (6.6); 7.6644 (16.0); 7.6613 (14.4); 7.5899 (9.7); 7.5562 (7.5); 7.5067 (1.1); 7.5000 (1.1); 7.4907 (3.3); 7.4804 (4.9); 7.4732 (4.4); 7.4602 (3.7); 7.4526 (2.4); 7.4313 (1.9); 7.4263 (1.6); 7.4033 (12.7); 7.3972 (18.7); 7.3674 (1.8); 7.2994 (11.8); 6.1390 (2.1); 6.1285 (2.4); 6.1149 (2.4); 6.1044 (2.2); 6.0681 (1.1); 6.0464 (3.3); 6.0247 (3.3); 6.0030 (1.2); 5.9834 (2.2); 5.9728 (2.4); 5.9594 (2.4); 5.9487 (2.2); 5.9101 (1.1); 5.8884 (3.3); 5.8666 (3.3); 5.8449 (1.1); 4.3933 (0.6); 4.3825 (0.8); 4.3771 (0.8); 4.3702 (0.9); 4.3663 (0.9); 4.3597 (0.9); 4.3547 (0.8); 4.3443 (1.3); 4.3338 (1.0); 4.3283 (1.0); 4.3216 (1.1); 4.3177 (1.1); 4.3110 (1.1); 4.3059 (1.0); 4.3016 (1.0); 4.2949 (1.0); 4.2909 (1.0); 4.2860 (0.9); 4.2785 (1.0); 4.2678 (0.9); 4.2635 (0.8); 4.2526 (1.3); 4.2417 (1.0); 4.2371 (1.0); 4.2298 (1.1); 4.2191 (1.0); 4.2150 (0.9); 4.2040 (0.7); 3.9151 (0.7); 3.8977 (1.0); 3.8918 (1.4); 3.8748 (1.5); 3.8676 (1.3); 3.8507 (1.4); 3.8441 (1.7); 3.8264 (1.9); 3.8040 (1.7); 3.7813 (1.1); 3.7738 (1.2); 3.7565 (1.0); 3.7504 (0.7); 3.7334 (0.6); 1.8583 (15.3); 1.8365 (15.3); 1.7772 (15.9); 1.7554 (15.0); 1.6136 (4.2); 1.5819 (0.3); 1.5611 (0.4); 1.2942 (5.3); 0.9406 (1.4); 0.9190 (3.8); 0.8957 (1.6); 0.1102 (1.7); 0.0479 (0.5); 0.0373 (8.7); 0.0265 (0.5)
I-553:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0984 (0.9); 9.0840 (2.0); 9.0693 (1.1); 8.6130 (4.0); 8.5796 (2.3); 8.5672 (2.4); 8.1087 (6.7); 7.9606 (3.0); 7.7913 (0.7); 7.7716 (2.1); 7.7522 (2.0); 7.7284 (5.2); 7.7074 (1.6); 7.6611 (2.0); 7.6359 (4.4); 7.5910 (2.6); 7.5699 (3.1); 7.5169 (2.8); 7.5045 (2.9); 7.3765 (1.9); 7.3722 (1.9); 7.3556 (1.7); 7.3512 (1.7); 6.0965 (0.6); 6.0841 (1.2); 6.0715 (0.7); 5.9810 (0.6); 5.9687 (1.2); 5.9562 (0.7); 3.9440 (1.0); 3.9301 (1.9); 3.9164 (1.2); 3.8865 (1.1); 3.8731 (1.8); 3.8595 (1.2); 3.3245 (55.0); 2.8985 (16.0); 2.7394 (15.1); 2.5092 (14.2); 2.3563 (15.3)
I-554:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5857 (0.4); 7.5595 (3.1); 7.5540 (2.9); 7.5491 (2.9); 7.5416 (7.4); 7.5384 (7.7); 7.4616 (3.6); 7.4377 (0.6); 7.4309 (0.5); 7.4233 (1.6); 7.4111 (2.2); 7.4043 (1.9); 7.3847 (4.3); 7.3581 (3.9); 7.2985 (11.7); 7.0691 (4.0); 6.9925 (2.2); 6.9656 (1.9); 6.6283 (1.0); 6.6083 (1.9); 6.5877 (1.0); 5.3365 (14.2); 4.4586 (0.7); 4.4494 (1.3); 4.4386 (1.9); 4.4291 (2.7); 4.4194 (1.8); 4.4087 (1.4); 4.3994 (0.7); 4.2672 (1.8); 4.2467 (1.7); 4.2173 (3.8); 4.1968 (3.6); 4.1674 (2.0); 4.1468 (1.8); 2.9789 (0.6); 2.8867 (0.6); 2.4996 (12.0); 2.4928 (6.9); 2.3183 (16.0); 2.0775 (0.4); 2.0378 (0.5); 1.6085 (1.4); 1.2940 (0.4); 0.9885 (0.8); 0.9789 (1.0); 0.9704 (2.4); 0.9617 (4.9); 0.9561 (4.2); 0.9471 (2.3); 0.9358 (1.4); 0.8866 (0.5); 0.8832 (0.5); 0.8778 (0.4); 0.8631 (0.4); 0.8285 (1.2); 0.8250 (1.2); 0.8060 (4.0); 0.7997 (2.6); 0.7927 (2.0); 0.7855 (3.1); 0.7792 (3.0); 0.7612 (0.7); 0.7578 (0.6); 0.1091 (0.9); 0.0491 (0.4); 0.0384 (11.3); 0.0274 (0.5)
I-555:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5839 (2.3); 7.5819 (2.4); 7.3926 (0.3); 7.3652 (6.6); 7.3608 (3.4); 7.3481 (1.3); 7.3320 (0.4); 7.3218 (2.6); 7.2986 (10.7); 7.1463 (0.4); 7.0142 (1.4); 6.9911 (2.0); 6.9882 (2.2); 6.9836 (2.1); 6.9645 (0.9); 6.9613 (0.9); 6.9565 (1.2); 6.9535 (0.9); 6.9064 (1.7); 6.9002 (2.1); 6.8934 (1.2); 6.6250 (0.5); 6.6057 (0.9); 6.5854 (0.5); 6.0620 (0.5); 6.0516 (0.6); 6.0397 (0.6); 6.0293 (0.5); 5.9073 (0.5); 5.8967 (0.6); 5.8849 (0.6); 5.8744 (0.5); 4.1858 (0.4); 4.1751 (0.4); 4.1639 (0.4); 4.1532 (0.4); 4.1484 (0.3); 4.0993 (0.4); 4.0886 (0.3); 4.0774 (0.3); 3.9551 (0.3); 3.9344 (0.5); 3.9131 (0.4); 3.8838 (0.4); 3.8790 (0.4); 3.8588 (0.5); 3.8369 (0.4); 3.8301 (0.3); 3.8102 (0.5); 3.7888 (0.4); 2.4083 (16.0); 1.9618 (0.5); 1.9507 (0.6); 1.9339 (1.1); 1.9173 (0.7); 1.9061 (0.6); 1.5982 (6.3); 1.3048 (1.8); 1.0398 (0.7); 1.0247 (2.0); 1.0179 (2.1); 1.0121 (1.2); 1.0030 (1.4); 0.9963 (2.2); 0.9898 (1.8); 0.9751 (1.0); 0.9417 (0.7); 0.9200 (2.0); 0.8968 (0.7); 0.7588 (1.0); 0.7436 (2.5); 0.7376 (2.1); 0.7271 (2.1); 0.7216 (2.5); 0.7052 (0.8); 0.1078 (0.8); 0.0487 (0.4); 0.0380 (9.8); 0.0270 (0.4)
I-556:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4620 (2.2); 7.4342 (4.4); 7.4252 (2.1); 7.3248 (1.3); 7.2987 (14.6); 7.2723 (1.7); 7.2292 (1.8); 7.2223 (1.6); 7.2014 (1.4); 7.1944 (1.3); 6.9864 (1.6); 6.9790 (2.9); 6.9512 (2.9); 6.9103 (2.0); 6.9039 (2.6); 6.8976 (1.3); 6.5313 (0.5); 6.5126 (0.9); 6.4930 (0.5); 6.0839 (0.6); 6.0732 (0.6); 6.0613 (0.6); 6.0511 (0.5); 5.9288 (0.6); 5.9185 (0.6); 5.9063 (0.6); 5.8957 (0.5); 4.2084 (0.4); 4.1937 (0.6); 4.1861 (0.4); 4.1696 (1.7); 4.1586 (0.4); 4.1460 (1.7); 4.1364 (0.4); 4.1213 (0.8); 4.1095 (0.4); 4.0981 (0.4); 4.0875 (0.4); 3.9428 (0.4); 3.9210 (0.5); 3.9011 (0.4); 3.8943 (0.4); 3.8684 (0.6); 3.8486 (0.6); 3.8261 (0.4); 3.8192 (0.4); 3.7970 (0.4); 2.6280 (16.0); 2.4486 (0.5); 2.3189 (16.0); 2.0815 (6.0); 1.9531 (0.6); 1.9418 (0.7); 1.9252 (1.3); 1.9083 (0.7); 1.8972 (0.7); 1.8800 (0.4); 1.6053 (6.3); 1.3202 (1.6); 1.2964 (3.2); 1.2726 (1.5); 1.0217 (0.8); 1.0060 (2.1); 0.9996 (2.3); 0.9849 (1.2); 0.9779 (2.3); 0.9713 (2.0); 0.9571 (1.0); 0.7548 (1.0); 0.7394 (2.6); 0.7336 (2.4); 0.7233 (2.2); 0.7171 (2.8); 0.7012 (0.8); 0.0484 (0.4); 0.0377 (11.8); 0.0270 (0.5)
I-557:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0057 (1.7); 8.9850 (1.8); 7.9601 (0.5); 7.6502 (2.1); 7.6305 (2.3); 7.4756 (1.3); 7.4553 (3.1); 7.4349 (2.0); 7.3992 (2.2); 7.3786 (2.6); 7.3220 (1.8); 7.3192 (1.8); 7.2991 (1.5); 7.2759 (4.9); 7.2302 (2.0); 7.2251 (3.4); 7.2201 (2.0); 7.1495 (2.7); 7.1302 (3.2); 7.1125 (1.3); 6.9134 (1.3); 6.8944 (2.2); 6.8761 (1.2); 5.4683 (0.9); 5.4501 (1.3); 5.4320 (0.9); 3.7168 (16.0); 3.3402 (77.7); 2.8974 (3.0); 2.7386 (2.8); 2.5304 (14.4); 2.5131 (7.0); 2.5092 (8.9); 2.5053 (6.9); 2.2270 (14.2); 1.5864 (6.1); 1.5695 (6.2)
I-558:1 H-NMR(300.2 MHz, CDCl3): δ= 9.2308 (1.6); 9.1825 (7.3); 8.3910 (13.3); 8.0233 (3.0); 7.9961 (3.5); 7.8767 (2.4); 7.8494 (4.2); 7.7892 (2.1); 7.7854 (2.0); 7.7664 (3.2); 7.7625 (3.4); 7.7389 (8.5); 7.7076 (4.8); 7.6809 (3.0); 7.6775 (3.1); 7.6540 (16.0); 7.6446 (5.3); 7.6326 (2.5); 7.6154 (0.6); 7.6097 (0.5); 7.3038 (13.3); 5.0190 (8.2); 5.0029 (8.2); 1.6593 (10.0); 1.2980 (0.4); 0.1137 (0.6); 0.0526 (0.5); 0.0418 (13.5); 0.0309 (0.5)
I-559:1 H-NMR(300.2 MHz, CDCl3): δ= 9.3197 (6.0); 8.6041 (5.0); 8.5841 (5.3); 8.3798 (0.4); 8.3722 (16.0); 8.0208 (4.3); 7.9934 (3.8); 7.8817 (4.1); 7.8617 (3.8); 7.7892 (2.6); 7.7686 (3.5); 7.6512 (3.7); 7.6273 (3.3); 7.6240 (3.8); 7.6131 (0.8); 7.6099 (0.8); 7.5962 (7.2); 7.5927 (8.6); 7.5835 (3.0); 7.5725 (3.7); 7.5463 (0.8); 7.3914 (3.6); 7.3889 (3.3); 7.3443 (1.6); 7.3374 (2.1); 7.3286 (1.1); 7.3226 (2.1); 7.3154 (2.4); 7.3062 (1.3); 7.3049 (1.4); 7.2987 (13.8); 7.2895 (0.4); 5.3346 (1.9); 5.2059 (7.8); 5.1868 (7.7); 1.6810 (3.4); 1.2908 (0.4); 0.0463 (0.4); 0.0355 (11.5); 0.0246 (0.4)
I-560:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.7800 (0.6); 8.7662 (1.1); 8.7518 (0.6); 8.0688 (5.7); 7.9993 (2.0); 7.9937 (2.1); 7.9539 (0.3); 7.7524 (0.4); 7.7327 (1.3); 7.7128 (1.5); 7.6965 (2.8); 7.6910 (2.3); 7.6034 (1.2); 7.5833 (0.9); 7.5773 (1.6); 7.5709 (1.2); 7.5559 (1.3); 7.5497 (1.2); 6.5529 (2.2); 6.5319 (2.1); 5.1233 (0.4); 5.1079 (1.1); 5.0924 (1.5); 5.0770 (1.2); 5.0615 (0.4); 3.5384 (0.7); 3.5219 (1.9); 3.5069 (2.0); 3.4905 (0.8); 3.3495 (59.7); 2.8926 (2.2); 2.7804 (1.3); 2.7637 (2.7); 2.7470 (1.2); 2.7338 (2.1); 2.5136 (6.9); 2.5096 (14.2); 2.5051 (18.9); 2.5007 (13.8); 1.2392 (0.6); 1.2218 (16.0); 1.2063 (15.7); -0.0002 (0.7)
I-561:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0588 (0.6); 9.0431 (1.3); 9.0273 (0.7); 7.9611 (0.8); 7.8713 (2.3); 7.8677 (2.4); 7.6063 (5.3); 7.4838 (1.4); 7.4626 (3.1); 7.4295 (1.7); 7.4252 (1.7); 7.4085 (0.9); 7.4041 (0.9); 7.3798 (1.2); 7.3594 (2.4); 7.3393 (1.4); 6.8729 (1.1); 6.8686 (1.2); 6.8532 (1.0); 6.8475 (1.2); 6.7437 (1.2); 6.7384 (2.6); 6.7322 (3.1); 6.7112 (1.4); 6.7063 (1.1); 4.2695 (0.6); 4.2539 (0.7); 4.2350 (1.4); 4.2192 (1.4); 4.2004 (0.8); 4.1845 (0.7); 3.7768 (16.0); 3.3151 (77.1); 2.8993 (5.2); 2.7404 (4.7); 2.5802 (13.3); 2.5138 (7.1); 2.5094 (9.8); 2.5050 (7.4)
I-562:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2163 (0.9); 9.2005 (2.0); 9.1846 (1.0); 8.6068 (4.7); 8.5735 (2.6); 8.5611 (2.8); 8.0276 (6.7); 7.9607 (3.0); 7.7930 (0.8); 7.7735 (2.3); 7.7538 (5.6); 7.7295 (2.9); 7.7101 (1.5); 7.6835 (3.4); 7.6222 (2.0); 7.6012 (4.2); 7.5798 (3.3); 7.4950 (2.8); 7.4825 (2.9); 7.2714 (1.8); 7.2674 (1.9); 7.2505 (1.7); 7.2462 (1.8); 4.3394 (0.9); 4.3239 (1.0); 4.3053 (2.0); 4.2899 (2.0); 4.2713 (1.1); 4.2550 (1.0); 3.3242 (113.7); 3.2751 (0.9); 2.8990 (16.0); 2.7398 (15.0); 2.5097 (15.8); 2.3391 (15.8)
I-563:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1544 (4.9); 7.9126 (0.7); 7.8933 (0.4); 7.6505 (1.4); 7.6242 (2.1); 7.6003 (1.2); 7.4802 (1.8); 7.4523 (2.5); 7.4314 (2.8); 7.4267 (2.2); 7.4038 (1.2); 7.3767 (0.6); 7.2988 (13.4); 7.2835 (1.6); 7.2767 (1.5); 7.2555 (1.2); 7.2488 (1.1); 6.1495 (0.4); 6.1393 (0.5); 6.1272 (0.5); 6.1166 (0.5); 5.9950 (0.5); 5.9841 (0.5); 5.9723 (0.5); 5.9616 (0.5); 5.3379 (5.3); 4.2965 (0.4); 4.2857 (0.4); 4.2746 (0.3); 4.2633 (0.4); 4.2583 (0.3); 4.2094 (0.4); 4.1985 (0.4); 4.1874 (0.4); 4.1765 (0.3); 3.9565 (0.3); 3.9386 (0.4); 3.9339 (0.4); 3.9162 (0.4); 3.8844 (0.5); 3.8658 (0.6); 3.8606 (0.4); 3.8425 (0.4); 3.8165 (0.3); 2.7660 (15.3); 2.0488 (0.4); 1.6022 (16.0); 1.2913 (0.4); 0.1064 (6.0); 0.0472 (0.6); 0.0364 (14.0); 0.0256 (0.6)
I-564:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4336 (1.4); 7.4271 (0.7); 7.4063 (4.1); 7.3871 (1.1); 7.3806 (3.8); 7.2983 (25.5); 7.2569 (1.2); 7.2533 (0.8); 7.2323 (1.8); 7.2075 (0.8); 7.2036 (0.6); 7.1941 (2.7); 7.1902 (3.3); 7.1830 (0.9); 7.1686 (1.5); 7.1651 (2.5); 7.0666 (2.1); 6.9829 (1.1); 6.9572 (1.0); 6.3210 (0.5); 6.3015 (0.8); 6.2814 (0.5); 5.3373 (12.9); 4.2655 (1.0); 4.2452 (0.9); 4.2162 (2.1); 4.1959 (2.0); 4.1668 (1.1); 4.1467 (1.1); 3.7510 (0.5); 3.7438 (0.5); 3.7172 (0.9); 3.6911 (0.5); 3.6830 (0.6); 2.6353 (0.3); 2.6055 (16.0); 2.5106 (6.0); 2.5037 (3.5); 2.4643 (0.4); 2.4580 (0.4); 2.4285 (1.1); 2.4213 (0.9); 2.4000 (1.4); 2.3926 (1.2); 2.3813 (0.6); 2.3727 (0.9); 2.3660 (0.9); 2.3531 (0.6); 2.3447 (0.6); 2.3233 (8.8); 2.2876 (1.3); 2.2811 (1.2); 2.2544 (0.9); 2.2462 (0.7); 2.0827 (0.9); 2.0485 (0.5); 2.0220 (0.8); 1.9870 (0.8); 1.9535 (0.4); 1.8467 (0.4); 1.8168 (0.7); 1.7870 (0.6); 1.5976 (12.5); 1.3208 (0.4); 1.2968 (1.2); 1.1646 (0.5); 1.1438 (0.4); 0.1746 (0.4); 0.1077 (53.4); 0.0954 (2.2); 0.0487 (1.0); 0.0380 (25.2); 0.0271 (0.9)
I-565:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9763 (8.4); 7.8553 (0.5); 7.7371 (0.8); 7.7228 (8.3); 7.7080 (0.6); 7.6616 (0.4); 7.6349 (0.4); 7.6064 (4.6); 7.6017 (3.5); 7.5891 (7.4); 7.5656 (0.7); 7.5257 (0.5); 7.4958 (3.7); 7.4748 (0.6); 7.4613 (1.7); 7.4521 (1.6); 7.4469 (2.2); 7.4407 (1.8); 7.4312 (1.4); 7.4230 (1.0); 7.3277 (3.3); 7.2986 (8.8); 7.2759 (0.3); 7.0551 (4.3); 6.9504 (2.2); 6.9243 (1.9); 6.7400 (1.0); 6.7200 (2.0); 6.6997 (1.1); 5.3356 (1.2); 4.1480 (1.7); 4.1275 (1.6); 4.0994 (3.5); 4.0788 (3.4); 4.0507 (1.8); 4.0301 (1.8); 2.5059 (0.3); 2.4649 (11.5); 2.3721 (0.7); 2.3455 (0.5); 2.3006 (16.0); 1.6555 (3.9); 0.1123 (0.5); 0.0400 (5.3)
I-566:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3972 (2.0); 7.3706 (2.3); 7.3075 (1.7); 7.2983 (13.9); 7.2817 (2.6); 7.2553 (1.7); 7.0882 (2.3); 7.0046 (1.4); 6.9792 (2.6); 6.9713 (2.8); 6.9642 (2.0); 6.9553 (1.2); 6.9521 (1.3); 6.9442 (2.2); 6.9390 (1.6); 6.8970 (2.0); 6.8907 (2.4); 6.8839 (1.3); 6.4526 (0.5); 6.4318 (1.0); 6.4122 (0.5); 4.2691 (1.1); 4.2482 (1.0); 4.2203 (2.3); 4.1994 (2.2); 4.1713 (1.2); 4.1505 (1.1); 2.6863 (0.3); 2.6198 (16.0); 2.5528 (0.6); 2.5323 (6.7); 2.5255 (3.9); 2.3898 (0.4); 2.3436 (8.9); 2.2657 (15.6); 2.1993 (0.3); 2.0449 (0.4); 1.9435 (0.6); 1.9324 (0.7); 1.9271 (0.5); 1.9155 (1.2); 1.8987 (0.7); 1.8876 (0.7); 1.8708 (0.4); 1.6071 (10.0); 1.2967 (1.4); 1.0149 (0.9); 0.9998 (2.2); 0.9928 (2.4); 0.9871 (1.3); 0.9780 (1.4); 0.9713 (2.3); 0.9646 (2.0); 0.9501 (1.2); 0.9414 (0.6); 0.9196 (1.4); 0.8963 (0.6); 0.7471 (1.1); 0.7320 (2.7); 0.7258 (2.4); 0.7155 (2.3); 0.7097 (2.8); 0.6934 (0.8); 0.1074 (0.5); 0.1041 (0.4); 0.0482 (0.6); 0.0375 (14.2); 0.0266 (0.6)
I-567:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2839 (9.2); 7.9537 (0.6); 7.9335 (1.0); 7.9145 (0.6); 7.8542 (0.4); 7.5916 (2.9); 7.5632 (3.6); 7.5268 (2.5); 7.5204 (2.7); 7.3648 (0.4); 7.3342 (1.8); 7.3275 (1.8); 7.3057 (2.0); 7.2984 (20.0); 7.2317 (0.4); 7.2101 (3.5); 7.1813 (4.4); 7.0478 (3.5); 7.0399 (4.2); 6.9755 (2.9); 6.9675 (2.4); 6.9468 (2.3); 6.9387 (1.9); 4.4861 (1.5); 4.4657 (1.4); 4.4375 (3.1); 4.4170 (2.9); 4.4034 (0.4); 4.3887 (1.6); 4.3683 (1.5); 2.0833 (0.4); 1.5881 (16.0); 1.3658 (0.3); 1.3434 (0.6); 1.3033 (3.7); 1.2971 (3.7); 0.9408 (1.3); 0.9189 (4.2); 0.8956 (1.6); 0.1032 (0.4); 0.0477 (0.7); 0.0368 (20.7); 0.0258 (0.8); -0.0298 (0.4)
I-568:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0047 (1.2); 8.9912 (2.4); 8.9772 (1.2); 8.3160 (0.3); 8.1277 (16.0); 7.7188 (1.0); 7.7006 (6.7); 7.6801 (5.2); 7.6738 (4.9); 7.6574 (1.0); 7.6542 (1.2); 7.6044 (1.8); 7.6002 (3.0); 7.5959 (1.8); 7.5814 (1.9); 7.2664 (0.5); 7.2601 (4.4); 7.2546 (1.6); 7.2412 (5.0); 7.2381 (6.4); 7.2256 (1.7); 7.2201 (4.9); 6.9315 (2.4); 6.9293 (2.0); 6.9145 (10.2); 6.9125 (10.3); 6.8930 (10.9); 4.1284 (3.6); 4.1147 (7.9); 4.1011 (4.1); 3.9026 (0.9); 3.7022 (2.1); 3.6886 (5.6); 3.6747 (5.4); 3.6608 (1.8); 3.3297 (180.6); 2.6756 (0.9); 2.6711 (1.2); 2.6666 (0.9); 2.5245 (4.2); 2.5196 (6.9); 2.5111 (80.0); 2.5067 (158.5); 2.5022 (205.0); 2.4976 (148.2); 2.4931 (73.0); 2.3380 (0.5); 2.3335 (0.9); 2.3289 (1.2); 2.3244 (0.9); -0.0002 (1.0)
I-569:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5401 (2.5); 7.5366 (2.7); 7.5298 (5.3); 7.5189 (1.6); 7.5060 (1.3); 7.4891 (0.6); 7.4169 (2.6); 7.3642 (0.9); 7.3567 (1.3); 7.3533 (1.2); 7.3463 (1.0); 7.3418 (0.7); 7.2606 (4.5); 6.9104 (0.6); 6.8927 (1.2); 6.8717 (0.7); 6.8520 (0.7); 6.8351 (1.3); 6.8192 (0.7); 6.6784 (0.7); 6.6660 (1.2); 6.6537 (0.7); 4.2920 (1.0); 4.2792 (1.0); 4.2631 (2.1); 4.2503 (2.1); 4.2341 (1.1); 4.2213 (1.0); 2.3305 (16.0); 1.5707 (9.1); 1.2567 (0.4); -0.0002 (3.7)
I-570:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.1830 (1.1); 9.1677 (2.3); 9.1520 (1.1); 7.9378 (11.6); 7.9285 (0.4); 7.4041 (2.0); 7.3845 (4.3); 7.3650 (2.7); 7.3333 (3.5); 7.3133 (3.9); 7.1666 (2.7); 7.1474 (2.3); 7.0902 (4.2); 7.0594 (4.2); 7.0425 (2.5); 7.0226 (2.0); 7.0180 (1.6); 6.9661 (2.2); 6.9463 (2.1); 4.1194 (1.2); 4.1038 (1.2); 4.0824 (2.6); 4.0666 (2.5); 4.0450 (1.3); 4.0295 (1.2); 3.3483 (16.5); 2.8976 (1.5); 2.7390 (1.3); 2.6862 (1.8); 2.6673 (5.2); 2.6483 (5.3); 2.6293 (1.8); 2.5179 (17.7); 2.5138 (33.7); 2.5093 (43.9); 2.5049 (32.8); 2.4240 (10.8); 2.2672 (0.6); 2.2405 (15.2); 2.1957 (0.5); 1.2275 (7.7); 1.2086 (16.0); 1.1896 (7.3)
I-571:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2740 (5.7); 7.6072 (4.3); 7.5925 (2.6); 7.5732 (0.6); 7.3934 (2.1); 7.3032 (0.8); 7.2979 (1.1); 7.2879 (1.1); 7.2824 (1.2); 7.2750 (0.8); 7.2595 (12.9); 6.9725 (2.2); 6.9521 (2.3); 6.3545 (2.5); 6.3487 (2.6); 6.1831 (1.5); 6.1772 (1.4); 6.1625 (1.4); 6.1567 (1.3); 3.7801 (1.2); 3.7653 (2.4); 3.7491 (2.4); 3.7344 (1.2); 3.6994 (15.4); 3.6732 (16.0); 2.9027 (1.9); 2.8865 (3.1); 2.8704 (1.7); 1.5443 (10.2); -0.0002 (12.3)
I-572:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5676 (0.3); 7.5419 (1.3); 7.5163 (3.5); 7.5113 (1.8); 7.4924 (0.4); 7.4396 (2.0); 7.4364 (1.6); 7.4219 (1.0); 7.4139 (1.5); 7.4062 (2.2); 7.3910 (0.9); 7.3796 (2.0); 7.2986 (6.6); 7.0922 (1.8); 7.0105 (1.0); 6.9839 (0.9); 6.3776 (0.4); 6.3572 (0.8); 6.3372 (0.4); 4.3003 (0.9); 4.2794 (0.9); 4.2514 (1.9); 4.2305 (1.8); 4.2025 (1.0); 4.1816 (0.9); 2.5375 (5.6); 2.5306 (3.2); 2.4307 (16.0); 2.3689 (0.4); 2.3323 (7.4); 2.1105 (0.6); 2.0997 (0.6); 2.0940 (0.4); 2.0834 (1.2); 2.0725 (0.5); 2.0668 (0.7); 2.0561 (0.6); 1.6068 (5.6); 1.2945 (0.5); 1.2698 (0.9); 1.2671 (0.8); 1.2518 (1.8); 1.2437 (2.1); 1.2357 (1.8); 1.2319 (1.5); 1.2273 (2.0); 1.2155 (0.8); 1.1062 (0.9); 1.0944 (2.0); 1.0858 (1.5); 1.0791 (1.2); 1.0672 (1.9); 1.0585 (1.5); 1.0439 (0.6); 0.1084 (0.5); 0.0376 (5.5)
I-573:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.7495 (0.6); 8.7356 (1.2); 8.7215 (0.6); 8.0677 (6.1); 7.9530 (0.4); 7.7552 (0.4); 7.7361 (1.3); 7.7156 (1.4); 7.6977 (4.2); 7.6807 (0.8); 7.6015 (1.3); 7.5822 (0.9); 6.7395 (2.4); 6.7350 (2.9); 6.6933 (0.8); 6.6886 (0.7); 6.6728 (2.0); 6.6680 (2.0); 6.6482 (3.9); 6.6278 (1.5); 4.1367 (16.0); 3.5056 (0.8); 3.4887 (2.0); 3.4735 (2.0); 3.4567 (0.8); 3.3454 (29.6); 3.3439 (29.5); 2.8915 (2.8); 2.7326 (3.9); 2.7149 (3.0); 2.6974 (1.4); 2.5127 (4.8); 2.5086 (10.1); 2.5041 (13.5); 2.4997 (9.9); 2.4955 (4.9); 1.2388 (0.4); -0.0002 (0.9)
I-574:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0484 (1.6); 9.0327 (3.3); 9.0168 (1.6); 7.9609 (2.5); 7.8710 (5.8); 7.8679 (6.0); 7.6027 (13.0); 7.4777 (3.5); 7.4564 (7.7); 7.4251 (4.4); 7.4210 (4.3); 7.4041 (2.0); 7.3999 (2.0); 7.3386 (2.8); 7.3189 (5.9); 7.2992 (3.5); 6.9922 (3.6); 6.9726 (3.3); 6.9168 (2.6); 6.9118 (3.1); 6.8967 (2.3); 6.8928 (3.0); 6.8657 (4.4); 6.8614 (5.9); 4.2677 (1.5); 4.2517 (1.6); 4.2331 (3.5); 4.2172 (3.4); 4.1985 (1.8); 4.1826 (1.6); 3.3142 (192.8); 2.8992 (16.0); 2.7401 (14.4); 2.5756 (32.7); 2.5509 (0.4); 2.5136 (19.7); 2.5093 (26.8); 2.5049 (19.8); 1.9989 (0.6); 1.9860 (1.3); 1.9776 (1.5); 1.9653 (2.7); 1.9528 (1.6); 1.9445 (1.5); 1.9317 (0.8); 1.0079 (1.6); 0.9969 (4.7); 0.9915 (5.1); 0.9812 (2.5); 0.9760 (4.9); 0.9707 (4.9); 0.9604 (1.8); 0.7100 (1.8); 0.6993 (5.6); 0.6945 (5.6); 0.6870 (5.2); 0.6821 (5.8); 0.6708 (1.6)
I-575:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1722 (0.9); 9.1567 (2.0); 9.1415 (1.0); 8.6089 (4.8); 8.5752 (2.7); 8.5628 (2.9); 8.0675 (6.9); 7.9606 (2.6); 7.7938 (0.7); 7.7742 (2.1); 7.7547 (2.1); 7.7300 (2.9); 7.7094 (4.8); 7.6826 (0.4); 7.6370 (2.0); 7.6170 (1.6); 7.5801 (2.8); 7.5591 (6.4); 7.5272 (6.3); 7.5049 (5.6); 7.4916 (3.3); 4.1877 (0.8); 4.1720 (1.0); 4.1533 (1.9); 4.1377 (2.0); 4.1186 (1.1); 4.1029 (1.0); 3.3254 (124.2); 2.8986 (14.2); 2.7395 (13.3); 2.5094 (16.6); 2.3462 (16.0)
I-576:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1064 (0.4); 9.0909 (0.8); 9.0755 (1.3); 9.0594 (0.6); 8.3102 (1.5); 7.7324 (0.8); 7.7129 (2.0); 7.6934 (1.8); 7.6813 (0.4); 7.6605 (6.3); 7.6475 (1.2); 7.6339 (0.8); 7.6262 (1.4); 7.5915 (2.4); 7.5729 (3.4); 7.5535 (3.0); 7.5431 (0.8); 7.5230 (1.9); 7.5045 (1.1); 7.2673 (1.4); 7.2440 (1.4); 7.2210 (0.3); 4.9624 (0.5); 4.8946 (2.7); 4.8794 (3.1); 4.8738 (3.1); 4.8587 (3.0); 4.5462 (0.4); 4.5144 (2.8); 4.4986 (4.9); 4.4828 (2.9); 4.2889 (0.8); 4.2726 (0.8); 4.2532 (1.6); 4.2372 (1.8); 4.2181 (1.5); 4.1997 (1.6); 4.1804 (0.6); 3.7184 (0.3); 3.6327 (0.4); 3.6184 (0.6); 3.6040 (0.4); 3.3239 (353.6); 3.2730 (0.4); 3.2672 (0.4); 3.2162 (1.2); 2.7118 (0.7); 2.6760 (1.4); 2.6716 (1.9); 2.6672 (1.4); 2.6029 (1.0); 2.5811 (16.0); 2.5611 (0.6); 2.5418 (166.3); 2.5249 (5.5); 2.5200 (8.4); 2.5114 (116.4); 2.5071 (229.6); 2.5026 (299.0); 2.4981 (219.5); 2.4939 (109.6); 2.4119 (1.0); 2.3681 (0.8); 2.3339 (1.4); 2.3294 (1.9); 2.3249 (1.4); 2.2952 (0.5); 1.3428 (0.4); -0.0002 (3.3)
I-577:1 H-NMR(499.9 MHz, CDCl3): δ= 8.3524 (7.7); 7.8845 (1.5); 7.7366 (0.3); 7.7245 (0.7); 7.7111 (0.8); 7.6993 (0.4); 7.6437 (0.3); 7.6268 (4.7); 7.6169 (6.6); 7.4839 (3.6); 7.4441 (0.4); 7.4362 (1.3); 7.4274 (2.0); 7.4240 (1.8); 7.4185 (1.5); 7.4134 (1.1); 7.3544 (0.4); 7.3381 (0.6); 7.3262 (3.6); 7.3104 (3.7); 7.2678 (0.8); 7.2587 (10.4); 7.2384 (0.6); 7.2131 (0.4); 7.0339 (4.2); 6.9391 (2.2); 6.9234 (2.1); 5.2965 (4.5); 4.2508 (1.6); 4.2390 (1.6); 4.2220 (3.4); 4.2102 (3.4); 4.1932 (1.8); 4.1814 (1.8); 3.4203 (8.0); 2.4716 (11.5); 2.3221 (0.7); 2.2777 (16.0); 1.5511 (5.1); 1.2564 (0.9); -0.0002 (9.8); -0.5243 (2.7)
I-578:1 H-NMR(400.1 MHz, CDCl3): δ= 8.7046 (0.6); 8.4073 (0.5); 8.2977 (5.7); 8.0171 (0.5); 7.8750 (1.9); 7.8680 (2.0); 7.6507 (2.0); 7.6288 (2.3); 7.4904 (1.0); 7.4885 (1.0); 7.4703 (1.3); 7.4685 (1.4); 7.3628 (1.4); 7.3425 (2.6); 7.3226 (2.6); 7.3181 (2.6); 7.3131 (1.6); 7.2736 (1.4); 7.2663 (1.6); 7.2598 (11.3); 7.2521 (1.6); 7.2446 (1.4); 7.1479 (1.2); 7.1440 (1.1); 7.1423 (1.1); 7.1274 (1.0); 7.1236 (0.9); 4.4407 (1.0); 4.4258 (1.0); 4.4091 (2.0); 4.3941 (2.0); 4.3772 (1.0); 4.3623 (0.9); 3.7928 (16.0); 3.7819 (1.5); 2.9545 (3.8); 2.8823 (3.5); 1.5547 (3.3); 0.0078 (0.6); -0.0002 (13.9); -0.0081 (0.6)
I-579:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1158 (1.4); 9.1000 (2.8); 9.0841 (1.4); 7.9612 (2.5); 7.8691 (5.0); 7.8656 (5.2); 7.6786 (0.3); 7.6449 (11.2); 7.5071 (3.4); 7.4859 (6.1); 7.4385 (3.4); 7.4343 (3.3); 7.4175 (1.9); 7.4133 (1.9); 7.1881 (1.3); 7.1680 (3.5); 7.1483 (2.8); 7.1210 (1.7); 7.1170 (2.0); 7.0995 (2.5); 7.0828 (1.1); 7.0790 (1.0); 6.9435 (1.4); 6.9399 (1.4); 6.9243 (2.5); 6.9075 (1.3); 4.2881 (1.3); 4.2728 (1.4); 4.2542 (3.0); 4.2383 (2.9); 4.2196 (1.5); 4.2036 (1.4); 3.3146 (181.3); 2.8992 (16.0); 2.7401 (14.3); 2.5781 (27.7); 2.5137 (17.7); 2.5093 (24.2); 2.5049 (18.0); 2.1067 (0.5); 2.0938 (1.0); 2.0854 (1.2); 2.0728 (2.0); 2.0602 (1.2); 2.0518 (1.1); 2.0389 (0.6); 1.0503 (1.2); 1.0392 (3.7); 1.0338 (4.0); 1.0236 (2.2); 1.0181 (3.8); 1.0128 (4.0); 1.0027 (1.6); 0.8088 (1.5); 0.7983 (4.3); 0.7937 (4.6); 0.7858 (4.2); 0.7809 (4.6); 0.7695 (1.3)
I-580:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0648 (0.8); 9.0502 (1.6); 9.0352 (0.9); 8.6262 (5.1); 8.3881 (2.9); 8.3761 (3.2); 8.2825 (0.4); 8.2480 (6.7); 7.9601 (2.4); 7.7911 (0.6); 7.7713 (2.0); 7.7612 (4.8); 7.7526 (4.2); 7.7301 (2.7); 7.7218 (3.6); 7.7098 (4.0); 7.6650 (1.6); 7.6451 (1.2); 7.4957 (7.6); 6.0893 (0.5); 6.0774 (0.9); 6.0641 (0.5); 5.9747 (0.5); 5.9625 (0.9); 5.9497 (0.6); 4.0095 (16.0); 3.9488 (0.5); 3.9342 (1.1); 3.9203 (1.0); 3.9094 (0.6); 3.8930 (0.6); 3.8780 (1.1); 3.8649 (1.0); 3.8539 (0.6); 3.3420 (138.3); 2.8980 (15.0); 2.7386 (13.5); 2.5141 (9.5); 2.5099 (13.1); 2.5057 (10.3)
I-581:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7622 (0.6); 8.2921 (1.5); 8.1408 (5.0); 7.7252 (0.8); 7.7221 (0.8); 7.7186 (0.8); 7.6983 (0.9); 7.6955 (0.9); 7.6919 (0.9); 7.3149 (1.7); 7.2986 (9.9); 7.2880 (1.5); 7.1572 (0.5); 7.1536 (0.4); 7.1303 (1.4); 7.1015 (1.3); 7.0799 (0.9); 7.0735 (1.1); 7.0564 (1.0); 7.0510 (1.2); 7.0297 (0.5); 7.0239 (0.5); 6.8787 (0.7); 6.8725 (0.7); 6.8521 (1.1); 6.8306 (0.6); 6.8252 (0.6); 6.7357 (1.0); 6.5494 (2.1); 6.3631 (1.1); 5.3365 (4.4); 4.0522 (1.0); 4.0330 (2.2); 4.0227 (0.6); 4.0122 (2.2); 3.9925 (1.1); 3.2426 (1.4); 3.2221 (2.1); 3.2020 (1.2); 2.7366 (16.0); 2.1304 (0.4); 2.1190 (0.5); 2.1021 (0.9); 2.0846 (0.5); 2.0737 (0.5); 1.6330 (12.1); 1.0829 (0.7); 1.0677 (1.8); 1.0608 (1.9); 1.0460 (1.0); 1.0391 (1.9); 1.0325 (1.7); 1.0178 (0.8); 0.8237 (0.9); 0.8087 (2.1); 0.8029 (2.0); 0.7919 (1.8); 0.7862 (2.2); 0.7696 (0.6); 0.1059 (5.1); 0.0461 (0.4); 0.0352 (10.2); 0.0244 (0.4)
I-582:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0017 (1.4); 8.9802 (1.4); 8.3108 (3.4); 7.8172 (6.4); 7.7165 (0.6); 7.6972 (1.6); 7.6771 (1.3); 7.6353 (2.0); 7.6203 (2.9); 7.5842 (1.3); 7.5618 (1.0); 7.3143 (1.8); 7.2945 (2.1); 7.1217 (2.6); 7.1103 (1.6); 7.0905 (1.2); 5.1837 (0.7); 5.1659 (0.7); 4.9188 (2.5); 4.9044 (2.9); 4.8981 (2.8); 4.8835 (2.8); 4.5595 (1.6); 4.5510 (1.8); 4.5429 (2.2); 4.5344 (2.3); 4.5281 (1.7); 4.5195 (1.6); 4.1953 (0.3); 4.1779 (0.7); 4.1577 (1.2); 4.1401 (0.7); 3.3253 (405.8); 2.7732 (0.5); 2.7587 (1.4); 2.7445 (1.5); 2.6807 (1.1); 2.6763 (2.2); 2.6717 (3.0); 2.6672 (2.2); 2.6630 (1.0); 2.6064 (16.0); 2.5864 (0.4); 2.5421 (2.1); 2.5251 (9.5); 2.5203 (14.9); 2.5117 (183.6); 2.5073 (366.2); 2.5027 (479.1); 2.4982 (347.3); 2.4937 (168.3); 2.3386 (1.0); 2.3341 (2.1); 2.3296 (2.9); 2.3250 (2.1); 2.3206 (1.0); 2.0727 (3.1); 2.0284 (0.3); 2.0022 (0.5); 1.9938 (0.6); 1.9708 (0.4); 1.9096 (0.4); 1.8851 (0.5); 1.8649 (0.5); 1.7816 (0.9); 1.7639 (1.3); 1.7540 (1.0); 1.7409 (0.9); -0.0001 (2.5)
I-583:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3932 (1.1); 9.3780 (2.2); 9.3630 (1.1); 8.3164 (0.4); 8.2205 (16.0); 7.7539 (0.9); 7.7344 (3.0); 7.7141 (10.2); 7.6989 (4.0); 7.6945 (2.6); 7.6893 (2.2); 7.6839 (2.0); 7.6699 (2.7); 7.6445 (2.6); 7.6399 (1.6); 7.6246 (1.6); 7.6195 (1.6); 7.6143 (1.6); 7.5944 (3.1); 7.5698 (2.7); 7.5508 (3.0); 7.5317 (1.0); 4.6487 (5.6); 4.6336 (5.6); 3.9027 (1.4); 3.3267 (116.1); 2.6798 (0.5); 2.6756 (1.0); 2.6711 (1.4); 2.6665 (1.0); 2.6621 (0.5); 2.5413 (0.9); 2.5245 (5.0); 2.5197 (7.7); 2.5111 (88.6); 2.5067 (176.0); 2.5021 (226.8); 2.4975 (161.9); 2.4930 (78.1); 2.3378 (0.4); 2.3334 (0.9); 2.3289 (1.3); 2.3244 (0.9); 2.3198 (0.4); 1.2358 (0.3); -0.0002 (1.1)
I-584:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3947 (13.5); 8.2842 (2.8); 8.1211 (0.4); 7.9864 (1.1); 7.9687 (1.8); 7.7166 (0.5); 7.6893 (4.3); 7.6718 (9.2); 7.6689 (8.3); 7.5582 (4.3); 7.5035 (1.2); 7.4894 (1.7); 7.4768 (3.9); 7.4689 (5.4); 7.4404 (6.8); 7.4100 (5.5); 7.3323 (3.5); 7.3041 (74.2); 6.9530 (0.3); 5.3438 (4.9); 4.4044 (8.8); 4.3221 (2.2); 4.3016 (2.2); 4.2730 (5.0); 4.2529 (4.8); 4.2239 (3.1); 4.2039 (2.8); 4.1717 (0.5); 4.1522 (0.7); 3.4736 (14.1); 3.4284 (3.0); 3.1743 (2.7); 3.1660 (10.6); 2.5589 (10.9); 2.5517 (16.0); 2.0891 (0.8); 2.0518 (5.5); 1.5955 (81.4); 1.3619 (0.7); 1.3255 (0.9); 1.2984 (2.4); 0.9245 (0.6); 0.8976 (0.4); 0.2387 (0.3); 0.1123 (1.9); 0.0534 (2.9); 0.0426 (72.1); 0.0317 (2.6)
I-585:1 H-NMR(400.1 MHz, CDCl3): δ= 9.0650 (2.3); 9.0538 (2.3); 8.5377 (5.8); 8.3488 (16.0); 7.7004 (5.9); 7.6338 (0.6); 7.5975 (12.6); 7.5788 (4.3); 7.5724 (4.0); 7.5620 (1.4); 7.5548 (1.7); 7.2597 (17.6); 5.1269 (0.9); 5.1150 (1.7); 5.1016 (1.8); 5.0885 (1.8); 5.0754 (0.9); 2.9678 (3.4); 2.9526 (5.5); 2.9300 (3.6); 2.9178 (2.0); 2.9073 (1.5); 2.8976 (2.0); 2.8843 (3.2); 2.8740 (0.7); 2.0826 (1.5); 2.0644 (3.1); 2.0519 (4.1); 2.0380 (3.3); 2.0234 (1.4); 2.0131 (0.8); 1.7403 (0.9); 1.7177 (1.1); 1.7134 (1.2); 1.7082 (1.2); 1.7002 (1.2); 1.6914 (1.7); 1.6818 (1.4); 1.6736 (1.2); 1.6681 (1.3); 1.6580 (1.2); 1.6416 (1.2); 1.6207 (0.9); 1.4319 (1.1); -0.0002 (5.0)
I-586:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2672 (16.0); 8.0157 (2.0); 7.6332 (1.6); 7.4803 (2.7); 7.4783 (2.8); 7.4763 (2.6); 7.4602 (3.6); 7.4582 (3.7); 7.3465 (3.9); 7.3261 (7.1); 7.3059 (3.5); 7.2718 (4.2); 7.2666 (7.2); 7.2594 (33.2); 7.0684 (3.1); 7.0646 (3.0); 7.0627 (2.9); 7.0495 (2.5); 7.0478 (2.7); 7.0440 (2.6); 6.7315 (3.1); 6.7272 (3.5); 6.7116 (4.1); 6.7074 (4.6); 6.6508 (2.3); 6.6467 (2.6); 6.6321 (4.8); 6.6281 (4.1); 6.5951 (5.4); 6.5757 (6.0); 6.5566 (2.4); 4.2084 (2.6); 4.2040 (5.0); 4.1994 (4.0); 4.1945 (6.7); 4.1906 (9.7); 4.1768 (9.6); 4.1730 (7.0); 4.1683 (4.1); 4.1636 (5.1); 4.1592 (2.8); 3.8102 (2.6); 3.7948 (5.8); 3.7785 (5.8); 3.7636 (2.8); 2.9538 (16.0); 2.9410 (5.0); 2.9244 (8.3); 2.9081 (4.6); 2.8818 (14.3); 1.5526 (12.4); 0.0078 (1.4); -0.0002 (39.6); -0.0083 (1.9)
I-587:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1806 (1.5); 9.1651 (3.1); 9.1493 (1.5); 7.9610 (2.7); 7.9485 (14.4); 7.7596 (5.2); 7.7552 (5.4); 7.5673 (4.8); 7.5460 (5.5); 7.3623 (2.6); 7.3426 (5.5); 7.3229 (3.2); 7.2681 (3.0); 7.2635 (3.0); 7.2470 (2.6); 7.2422 (2.6); 7.0315 (3.4); 7.0116 (3.0); 6.9575 (2.6); 6.9534 (2.9); 6.9373 (2.2); 6.9333 (2.7); 6.8965 (4.0); 6.8920 (5.5); 4.2868 (1.5); 4.2711 (1.6); 4.2524 (3.3); 4.2366 (3.2); 4.2177 (1.7); 4.2018 (1.6); 3.3139 (159.6); 2.8991 (16.0); 2.7401 (14.4); 2.5135 (16.8); 2.5092 (22.7); 2.5049 (16.8); 2.0073 (0.6); 1.9943 (1.2); 1.9860 (1.4); 1.9736 (2.5); 1.9610 (1.5); 1.9527 (1.4); 1.9398 (0.7); 1.0145 (1.5); 1.0035 (4.4); 0.9981 (4.8); 0.9877 (2.4); 0.9826 (4.6); 0.9773 (4.5); 0.9670 (1.7); 0.7156 (1.7); 0.7047 (5.2); 0.7001 (5.2); 0.6925 (4.9); 0.6876 (5.4); 0.6763 (1.5)
I-588:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.0499 (0.8); 9.0353 (1.6); 9.0201 (0.9); 8.6250 (5.0); 8.3877 (2.8); 8.3757 (3.1); 8.2507 (6.8); 7.9605 (2.4); 7.7880 (0.6); 7.7685 (1.8); 7.7475 (4.0); 7.7237 (4.8); 7.7111 (3.7); 7.6629 (1.6); 7.6407 (3.9); 7.5820 (2.3); 7.5610 (2.9); 7.3782 (1.7); 7.3734 (1.7); 7.3573 (1.5); 7.3524 (1.4); 6.1043 (0.5); 6.0920 (0.9); 6.0791 (0.5); 5.9892 (0.5); 5.9765 (0.9); 5.9639 (0.6); 4.0088 (16.0); 3.9774 (0.4); 3.9566 (0.6); 3.9407 (1.2); 3.9263 (1.2); 3.9137 (0.6); 3.9012 (0.6); 3.8853 (1.2); 3.8707 (1.1); 3.8587 (0.6); 3.3232 (105.9); 2.8985 (14.1); 2.7395 (12.9); 2.5132 (9.0); 2.5092 (12.2); 2.5050 (9.4)
I-589:1 H-NMR(601.6 MHz, CD3CN): δ= 9.2049 (1.2); 8.2135 (16.0); 7.8156 (1.3); 7.7086 (1.5); 7.6955 (4.3); 7.6822 (3.9); 7.6664 (5.4); 7.6533 (2.3); 7.6443 (1.4); 7.6312 (0.7); 7.6196 (0.4); 7.5903 (4.9); 7.5506 (1.7); 7.5352 (0.5); 7.5202 (2.9); 7.5070 (2.4); 7.4891 (1.1); 7.4828 (6.5); 7.4729 (1.5); 7.4688 (7.2); 7.4615 (2.1); 7.4590 (1.3); 7.4473 (2.6); 7.4444 (5.0); 7.4422 (5.8); 7.4413 (5.8); 7.4391 (4.9); 7.4324 (1.9); 7.4303 (1.8); 7.4271 (1.4); 7.2509 (4.0); 7.2474 (3.9); 7.2369 (3.8); 7.2335 (3.6); 7.2260 (0.5); 7.2226 (0.6); 7.2199 (0.5); 7.2118 (0.4); 7.2085 (0.4); 7.2034 (1.1); 7.2000 (1.0); 7.1895 (1.0); 7.1860 (0.9); 7.1320 (0.5); 7.0672 (0.8); 7.0487 (4.1); 6.9778 (1.8); 6.9583 (7.8); 6.8885 (0.9); 6.8680 (3.8); 6.0730 (1.4); 6.0661 (1.6); 6.0631 (1.6); 6.0563 (1.5); 6.0304 (0.5); 6.0238 (0.6); 6.0209 (0.6); 6.0141 (0.5); 5.9967 (1.4); 5.9899 (1.6); 5.9868 (1.7); 5.9800 (1.5); 5.9542 (0.4); 5.9476 (0.5); 5.9446 (0.6); 5.9379 (0.5); 4.0246 (0.8); 4.0178 (0.9); 4.0142 (1.0); 4.0075 (1.0); 4.0005 (1.4); 3.9937 (1.4); 3.9901 (1.6); 3.9881 (1.3); 3.9833 (1.7); 3.9777 (1.3); 3.9710 (1.1); 3.9638 (1.5); 3.9570 (1.4); 3.9534 (1.4); 3.9508 (0.6); 3.9466 (1.4); 3.9402 (0.8); 3.9363 (1.4); 3.9295 (0.9); 3.9262 (2.5); 3.9193 (0.6); 3.9160 (1.5); 3.9122 (0.9); 3.9049 (0.6); 3.9020 (1.6); 3.8989 (1.6); 3.8949 (0.5); 3.8916 (1.2); 3.8886 (2.7); 3.8784 (1.4); 3.8747 (1.1); 3.8645 (1.6); 3.8544 (0.8); 3.5400 (0.4); 2.3743 (0.8); 2.1284 (169.7); 2.0262 (0.4); 2.0221 (0.5); 2.0180 (0.3); 1.9358 (3.0); 1.9277 (1.9); 1.9235 (2.4); 1.9197 (25.4); 1.9156 (46.7); 1.9115 (69.1); 1.9074 (48.2); 1.9033 (25.3); 1.7968 (0.4); 1.5046 (0.3); 1.2430 (1.2)
I-590:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5655 (1.7); 7.5397 (2.7); 7.5165 (1.6); 7.4768 (2.2); 7.4488 (2.8); 7.4325 (1.9); 7.4279 (2.4); 7.4222 (1.9); 7.3555 (1.0); 7.3281 (1.4); 7.2986 (6.0); 7.2650 (1.8); 7.2583 (1.7); 7.2371 (1.4); 7.2304 (1.3); 6.5175 (0.5); 6.4977 (0.9); 6.4787 (0.5); 6.1064 (0.5); 6.0958 (0.6); 6.0835 (0.6); 6.0730 (0.5); 5.9513 (0.5); 5.9407 (0.6); 5.9285 (0.6); 5.9179 (0.5); 5.3350 (0.5); 4.2199 (0.4); 4.2091 (0.4); 4.1982 (0.4); 4.1873 (0.4); 4.1816 (0.4); 4.1325 (0.4); 4.1216 (0.4); 4.1108 (0.4); 4.1000 (0.4); 3.9944 (0.4); 3.9744 (0.5); 3.9519 (0.4); 3.9457 (0.3); 3.9216 (0.6); 3.9012 (0.7); 3.8780 (0.4); 3.8717 (0.3); 3.8515 (0.4); 2.6274 (15.6); 2.4494 (0.4); 2.3354 (16.0); 2.0769 (0.4); 1.3033 (0.5); 1.2935 (0.5); 0.9184 (0.5); 0.0364 (3.6)
I-591:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2041 (1.7); 9.1830 (1.8); 8.1809 (6.8); 7.9603 (2.5); 7.3602 (3.3); 7.3211 (0.4); 7.2958 (7.4); 7.2751 (0.4); 7.2513 (0.6); 7.2304 (1.6); 7.2093 (1.3); 7.1749 (1.1); 7.1571 (1.6); 7.1382 (0.7); 6.9819 (0.9); 6.9788 (0.9); 6.9622 (1.7); 6.9450 (0.9); 5.1557 (0.4); 5.1398 (0.9); 5.1229 (1.0); 5.1043 (0.4); 3.9050 (16.0); 3.3295 (19.5); 2.8978 (14.4); 2.7893 (0.6); 2.7717 (1.7); 2.7573 (1.8); 2.7384 (13.9); 2.7141 (0.4); 2.5126 (10.5); 2.5088 (13.4); 2.0379 (0.3); 2.0232 (0.5); 2.0119 (0.5); 1.9938 (0.8); 1.9799 (0.5); 1.9053 (0.4); 1.8951 (0.6); 1.8794 (0.6); 1.8619 (0.6); 1.8400 (0.5); 1.8171 (0.8); 1.7975 (1.2); 1.7873 (1.5); 1.7730 (1.1)
I-592:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.9659 (1.0); 8.9459 (1.1); 8.3108 (16.0); 7.8048 (4.7); 7.7153 (0.5); 7.6947 (1.1); 7.6747 (1.0); 7.6347 (1.4); 7.6182 (2.4); 7.5807 (1.0); 7.5588 (0.8); 7.2358 (1.4); 7.2159 (1.5); 6.9337 (2.3); 6.9106 (1.0); 5.1567 (0.5); 5.1373 (0.6); 3.4867 (0.4); 3.4469 (0.7); 3.4258 (1.0); 3.4039 (1.1); 3.3771 (1.2); 3.3257 (2037.8); 3.2781 (0.8); 2.7237 (0.9); 2.7085 (1.0); 2.6948 (0.7); 2.6805 (4.4); 2.6762 (9.4); 2.6716 (13.0); 2.6670 (9.6); 2.6626 (4.5); 2.6031 (11.9); 2.5251 (40.8); 2.5204 (62.5); 2.5117 (793.6); 2.5072 (1605.9); 2.5027 (2116.2); 2.4981 (1533.9); 2.4935 (743.0); 2.3637 (0.7); 2.3386 (4.6); 2.3340 (9.5); 2.3295 (13.2); 2.3249 (9.6); 2.3204 (4.5); 2.2621 (0.6); 2.2500 (1.0); 2.2440 (1.3); 2.2302 (1.0); 2.2233 (1.6); 2.2156 (0.9); 2.2009 (0.7); 2.1756 (0.5); 2.0728 (2.1); 2.0556 (0.5); 2.0503 (0.5); 2.0299 (0.8); 2.0041 (1.1); 1.9856 (1.9); 1.9806 (1.3); 1.9690 (1.6); 1.9504 (1.1); 1.9251 (0.6); 1.9091 (0.5); 1.8660 (0.6); 1.8452 (0.5); 1.8008 (0.5); 1.7831 (1.0); 1.7653 (1.0); 1.7444 (1.1); 1.2356 (0.6); 0.0079 (0.4); -0.0002 (9.5); -2.6466 (0.3)
I-593:1 H-NMR(400.1 MHz, CDCl3): δ= 8.3317 (10.0); 8.0869 (1.4); 8.0187 (2.3); 7.8923 (1.1); 7.8723 (1.1); 7.5807 (4.7); 7.5679 (6.8); 7.5397 (0.5); 7.5189 (0.7); 7.4766 (3.7); 7.4428 (0.5); 7.4324 (1.4); 7.4216 (2.0); 7.4170 (1.7); 7.4104 (1.3); 7.4038 (0.9); 7.3216 (0.6); 7.2590 (24.1); 7.2309 (0.3); 7.1925 (4.0); 7.1798 (4.2); 6.7883 (4.4); 6.7755 (4.1); 5.4852 (0.6); 5.4704 (1.4); 5.4519 (1.2); 5.4410 (0.6); 2.9566 (16.0); 2.8838 (15.0); 2.6752 (3.4); 2.6620 (2.0); 2.6184 (0.6); 2.3528 (0.4); 2.3403 (0.5); 2.3292 (1.4); 2.3164 (1.0); 2.3121 (1.0); 2.2909 (0.7); 2.2704 (0.6); 1.9141 (2.6); 1.9030 (4.3); 1.8990 (4.5); 1.8909 (3.2); 1.5892 (0.9); 1.4319 (3.4); -0.0002 (6.7)
I-594:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1476 (1.4); 9.1333 (2.7); 9.1182 (1.3); 8.1096 (0.5); 8.0712 (12.8); 7.9610 (2.4); 7.7626 (5.6); 7.5289 (0.9); 7.5249 (0.8); 7.5079 (5.6); 7.5037 (6.4); 7.4994 (8.7); 7.4783 (1.3); 7.2096 (0.9); 7.1890 (3.8); 7.1820 (2.3); 7.1727 (6.6); 7.1657 (2.4); 7.1608 (2.4); 7.1455 (0.7); 7.1404 (0.5); 6.9749 (1.2); 6.9657 (1.2); 6.9588 (2.0); 6.9522 (2.0); 6.9395 (1.2); 6.9344 (1.0); 6.0612 (0.9); 6.0499 (1.4); 6.0361 (0.9); 5.9459 (0.9); 5.9348 (1.4); 5.9207 (1.0); 3.9104 (0.8); 3.8957 (2.1); 3.8825 (1.6); 3.8724 (1.1); 3.8531 (1.0); 3.8381 (2.2); 3.8235 (1.8); 3.8136 (0.9); 3.3138 (168.1); 2.8991 (16.0); 2.7400 (14.2); 2.5136 (17.6); 2.5092 (23.9); 2.5049 (17.7); 2.1141 (0.5); 2.1013 (1.0); 2.0928 (1.1); 2.0803 (2.0); 2.0675 (1.2); 2.0592 (1.1); 2.0464 (0.5); 1.0550 (1.2); 1.0440 (3.6); 1.0386 (3.9); 1.0284 (2.1); 1.0230 (3.6); 1.0176 (3.8); 1.0075 (1.5); 0.8123 (1.5); 0.8018 (4.1); 0.7972 (4.4); 0.7892 (4.0); 0.7843 (4.3); 0.7731 (1.2)
I-595:1 H-NMR(601.6 MHz, CD3CN): δ= 9.2569 (16.0); 8.0574 (1.0); 7.7494 (2.2); 7.7362 (6.2); 7.7230 (4.9); 7.7011 (5.8); 7.6881 (3.1); 7.6072 (8.0); 7.6065 (8.2); 7.6037 (5.7); 7.5486 (3.6); 7.5476 (3.9); 7.5469 (3.8); 7.5459 (3.6); 7.5448 (3.5); 7.5352 (3.2); 7.5344 (3.3); 7.5334 (3.3); 7.5324 (3.1); 7.5315 (3.0); 7.5305 (2.9); 7.5179 (9.5); 7.5039 (10.7); 7.4895 (6.9); 7.4873 (7.8); 7.4861 (8.0); 7.4840 (7.2); 7.2600 (6.3); 7.2565 (6.2); 7.2460 (5.6); 7.2425 (5.6); 7.1221 (5.1); 7.0327 (11.2); 6.9435 (5.6); 6.0867 (2.1); 6.0802 (2.3); 6.0768 (2.4); 6.0703 (2.2); 6.0104 (2.1); 6.0040 (2.3); 6.0006 (2.4); 5.9941 (2.2); 4.0687 (1.2); 4.0623 (1.2); 4.0585 (1.2); 4.0521 (1.2); 4.0444 (2.3); 4.0379 (2.3); 4.0341 (2.3); 4.0310 (1.5); 4.0277 (2.4); 4.0246 (1.3); 4.0208 (1.4); 4.0143 (1.2); 4.0066 (2.4); 4.0002 (2.2); 3.9964 (4.5); 3.9899 (2.3); 3.9862 (3.7); 3.9760 (2.3); 3.9721 (1.4); 3.9618 (2.0); 3.9569 (2.3); 3.9516 (1.3); 3.9466 (3.7); 3.9364 (2.2); 3.9325 (1.4); 3.9222 (2.0); 3.9120 (1.2); 2.5362 (1.5); 2.2025 (335.7); 2.1155 (0.9); 2.1035 (0.4); 2.0949 (0.3); 2.0867 (0.6); 2.0826 (1.0); 2.0786 (1.3); 2.0745 (0.9); 2.0703 (0.5); 1.9923 (18.4); 1.9842 (5.2); 1.9800 (5.6); 1.9762 (70.3); 1.9721 (129.8); 1.9680 (177.6); 1.9638 (126.8); 1.9597 (65.8); 1.9551 (2.1); 1.9509 (1.1); 1.8614 (0.4); 1.8573 (0.8); 1.8532 (1.2); 1.8492 (0.8); 1.8450 (0.4); 1.6599 (0.6); 1.5004 (0.5); 1.4186 (0.8); 1.2993 (0.7)
I-596:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5458 (2.6); 7.5367 (3.0); 7.5298 (3.0); 7.5158 (5.8); 7.4715 (0.4); 7.4281 (3.8); 7.3796 (2.0); 7.3661 (2.1); 7.2558 (2.1); 7.0468 (2.4); 7.0312 (3.0); 7.0120 (1.3); 6.9589 (4.6); 6.8645 (2.5); 6.8502 (2.1); 6.1944 (0.7); 6.0500 (1.0); 6.0399 (1.6); 5.2892 (0.4); 3.7628 (1.9); 3.7497 (4.4); 3.7371 (4.5); 3.7245 (2.0); 3.0628 (1.6); 3.0480 (4.1); 3.0331 (4.1); 3.0182 (1.6); 2.9471 (3.0); 2.9337 (5.4); 2.9206 (3.2); 2.2942 (15.4); 2.2877 (9.5); 2.2497 (16.0); 2.1681 (0.7); 1.5881 (0.8); 1.4000 (0.4); 1.3851 (0.6); 1.3579 (4.5); 1.3431 (8.3); 1.3282 (4.2); 1.2583 (0.5); 1.2520 (0.4); -0.0002 (2.0)
I-597:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8980 (5.7); 7.8736 (0.4); 7.8547 (0.6); 7.8359 (0.4); 7.7172 (1.7); 7.7091 (1.3); 7.7005 (3.2); 7.6973 (3.3); 7.5608 (1.5); 7.5302 (2.0); 7.5011 (3.9); 7.4934 (1.5); 7.4866 (1.1); 7.4766 (0.8); 7.4680 (0.5); 7.4370 (3.4); 7.4089 (1.8); 7.2982 (7.6); 4.2956 (1.0); 4.2755 (0.9); 4.2477 (2.0); 4.2276 (1.9); 4.1998 (1.0); 4.1797 (1.0); 2.8443 (16.0); 1.5892 (5.8); 0.0369 (7.6)
I-598:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2758 (1.7); 9.2601 (3.6); 9.2444 (1.9); 8.0059 (16.0); 7.9616 (1.3); 7.7558 (5.8); 7.7514 (6.2); 7.5949 (5.5); 7.5735 (6.4); 7.2861 (3.4); 7.2814 (3.5); 7.2651 (3.1); 7.2602 (3.1); 7.2066 (1.6); 7.1870 (4.4); 7.1672 (3.7); 7.1409 (2.2); 7.1369 (2.6); 7.1196 (3.2); 7.1027 (1.5); 7.0990 (1.4); 6.9755 (1.8); 6.9720 (1.9); 6.9564 (3.2); 6.9394 (1.7); 4.3046 (1.7); 4.2889 (1.8); 4.2701 (3.8); 4.2544 (3.8); 4.2357 (2.1); 4.2197 (1.9); 3.3140 (192.8); 2.8994 (7.2); 2.7405 (6.5); 2.5137 (20.5); 2.5094 (28.1); 2.5051 (21.4); 2.1139 (0.6); 2.1009 (1.2); 2.0925 (1.4); 2.0799 (2.6); 2.0673 (1.7); 2.0590 (1.5); 2.0462 (0.8); 1.0576 (1.5); 1.0465 (4.6); 1.0412 (5.1); 1.0307 (2.8); 1.0254 (4.9); 1.0201 (5.1); 1.0099 (2.2); 0.8149 (1.9); 0.8041 (5.4); 0.7997 (5.8); 0.7917 (5.5); 0.7869 (6.0); 0.7754 (1.9)
I-599:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1950 (1.7); 9.1806 (3.2); 9.1688 (1.9); 8.8569 (6.9); 8.8514 (7.2); 8.7188 (3.7); 8.7123 (3.9); 8.7065 (4.3); 8.7025 (4.0); 8.7000 (4.0); 8.1989 (8.0); 8.1950 (7.7); 8.1920 (7.8); 8.0712 (0.7); 8.0642 (0.7); 7.9604 (4.0); 7.8050 (1.0); 7.7834 (3.1); 7.7485 (11.0); 7.7238 (5.9); 7.7193 (5.4); 7.7114 (4.6); 7.7068 (4.5); 7.6633 (4.0); 7.6448 (2.9); 7.5762 (4.7); 7.5556 (9.4); 7.5230 (9.3); 7.5061 (5.3); 4.1906 (1.5); 4.1759 (1.7); 4.1572 (3.3); 4.1428 (3.3); 4.1255 (2.1); 4.1098 (2.0); 3.3414 (145.0); 3.3374 (142.9); 3.3348 (144.3); 2.9019 (15.6); 2.8974 (15.6); 2.8959 (16.0); 2.7422 (14.7); 2.7378 (15.4); 2.7366 (15.5); 2.5099 (28.4); 1.2440 (0.4)
I-600:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2625 (1.4); 9.2423 (1.5); 8.1044 (6.2); 7.9607 (1.4); 7.3865 (1.1); 7.3663 (2.3); 7.3462 (1.3); 6.8820 (1.1); 6.8777 (1.4); 6.8568 (1.6); 6.8397 (7.6); 6.8167 (1.5); 5.1257 (0.8); 5.1075 (0.8); 5.0921 (0.4); 3.7671 (16.0); 3.3300 (15.4); 2.8982 (8.6); 2.7388 (8.0); 2.5457 (0.6); 2.5302 (1.6); 2.5134 (9.4); 2.5092 (11.6); 2.5050 (8.9); 2.0517 (0.5); 2.0392 (0.6); 2.0306 (0.6); 2.0178 (0.5); 1.9038 (0.4); 1.8917 (0.4); 1.8784 (0.6); 1.8571 (0.5); 1.8425 (0.5); 1.8227 (0.6); 1.8038 (0.6); 1.7910 (1.0); 1.7766 (1.2)
I-601:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3411 (0.4); 8.3036 (8.0); 7.7790 (1.0); 7.6751 (0.5); 7.6579 (5.4); 7.6497 (2.4); 7.6370 (2.4); 7.6106 (0.6); 7.3808 (2.6); 7.3317 (1.1); 7.3246 (1.5); 7.3096 (1.4); 7.3022 (3.7); 7.2943 (0.8); 7.2123 (4.6); 7.1856 (5.6); 6.9322 (4.5); 6.9060 (3.7); 5.3366 (2.0); 3.6945 (5.9); 3.6771 (5.8); 2.3934 (0.3); 2.2062 (16.0); 1.6721 (1.2); 1.2995 (0.4); 0.9864 (0.3); 0.9543 (8.0); 0.9447 (8.0); 0.9119 (0.4); 0.1177 (0.5); 0.0426 (2.1)
I-602:1 H-NMR(300.1 MHz, CDCl3): δ= 9.1779 (0.8); 8.0086 (7.3); 7.9840 (0.4); 7.6066 (0.6); 7.5614 (3.5); 7.5184 (0.6); 7.4965 (5.5); 7.4737 (2.1); 7.4474 (0.6); 7.4088 (1.6); 7.3860 (2.6); 7.3311 (1.3); 7.3076 (2.3); 7.2799 (1.8); 7.2607 (102.6); 7.2168 (4.4); 7.1886 (3.4); 7.1634 (2.3); 7.0760 (2.2); 7.0510 (1.5); 6.9096 (0.5); 4.0866 (16.0); 3.9056 (2.4); 3.4898 (0.9); 3.1938 (1.9); 3.1722 (2.9); 3.1519 (1.7); 2.0078 (0.6); 1.6068 (8.6); 0.1955 (0.4); 0.0106 (4.4); -0.0001 (85.7); -0.0111 (3.0); -0.1988 (0.4)
I-603:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4021 (9.1); 8.0709 (1.0); 7.9036 (2.9); 7.8916 (1.6); 7.8754 (4.3); 7.8599 (1.9); 7.8397 (4.4); 7.8101 (1.7); 7.6526 (0.3); 7.6261 (5.4); 7.6089 (4.5); 7.5802 (0.5); 7.5614 (0.8); 7.5578 (0.7); 7.5477 (4.6); 7.5385 (2.9); 7.5350 (2.8); 7.5243 (4.3); 7.5162 (8.6); 7.4893 (2.0); 7.4838 (1.8); 7.4527 (1.2); 7.4447 (1.3); 7.4339 (1.6); 7.4277 (1.4); 7.4223 (0.9); 7.4143 (0.7); 7.3040 (13.9); 4.9408 (5.6); 4.9216 (5.6); 1.6062 (16.0); 1.3276 (0.4); 1.2989 (1.5); 0.1149 (0.5); 0.0547 (0.5); 0.0440 (13.2); 0.0331 (0.6)
I-604:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5222 (1.6); 7.5018 (4.7); 7.4990 (4.0); 7.4850 (0.4); 7.4814 (0.4); 7.4416 (2.2); 7.3985 (0.9); 7.3885 (1.5); 7.3810 (1.2); 7.3737 (2.5); 7.3601 (0.7); 7.3470 (2.4); 7.2987 (1.5); 7.0767 (2.4); 6.9897 (1.3); 6.9610 (1.5); 6.9367 (1.2); 6.9161 (0.6); 4.2415 (1.0); 4.2206 (0.9); 4.1923 (2.0); 4.1714 (2.0); 4.1431 (1.0); 4.1222 (1.0); 2.5559 (16.0); 2.5119 (6.9); 2.3596 (0.4); 2.3250 (9.2); 2.2189 (15.8); 1.7781 (1.3); 1.2966 (0.4); 0.0375 (1.3)
I-605:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9255 (5.6); 7.8860 (0.4); 7.8685 (0.7); 7.8499 (0.4); 7.7239 (1.5); 7.7165 (1.2); 7.7119 (1.3); 7.7051 (3.6); 7.7024 (3.6); 7.6900 (0.4); 7.5903 (2.7); 7.5861 (2.5); 7.5767 (1.8); 7.5167 (0.7); 7.5060 (1.0); 7.4989 (1.0); 7.4863 (0.8); 7.4782 (0.5); 7.4316 (0.4); 7.4036 (2.8); 7.3951 (4.4); 7.3668 (0.4); 7.2988 (7.6); 6.1374 (0.5); 6.1267 (0.6); 6.1132 (0.6); 6.1024 (0.5); 5.9816 (0.5); 5.9709 (0.6); 5.9574 (0.6); 5.9467 (0.5); 4.3399 (0.3); 4.3293 (0.3); 4.3173 (0.3); 4.3066 (0.4); 4.2482 (0.3); 4.2255 (0.4); 4.2147 (0.3); 4.1924 (0.7); 4.1685 (2.2); 4.1447 (2.2); 4.1210 (0.8); 3.8885 (0.4); 3.8810 (0.4); 3.8641 (0.4); 3.8567 (0.3); 3.8366 (0.5); 3.8193 (0.4); 3.8148 (0.4); 3.7953 (0.3); 2.8442 (16.0); 2.0812 (10.0); 1.6028 (6.0); 1.3192 (2.6); 1.2954 (5.1); 1.2716 (2.5); 0.0358 (7.6)
I-606:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2101 (5.0); 7.9827 (0.6); 7.9558 (0.6); 7.6176 (1.4); 7.5982 (3.8); 7.5949 (3.6); 7.5234 (1.7); 7.4740 (0.7); 7.4637 (1.1); 7.4565 (0.9); 7.4434 (0.7); 7.4362 (0.4); 7.2997 (18.2); 6.6290 (4.6); 5.4034 (0.6); 5.3791 (0.6); 2.7810 (16.0); 2.6205 (1.4); 2.6075 (1.3); 2.3103 (0.6); 2.2974 (0.5); 2.2838 (0.4); 2.2674 (0.4); 2.0843 (0.9); 1.9342 (1.3); 1.9244 (1.2); 1.9147 (2.6); 1.9031 (1.3); 1.8954 (1.3); 1.5851 (8.8); 1.2987 (0.5); 0.0501 (0.7); 0.0393 (19.1); 0.0283 (0.7)
I-607:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2742 (1.7); 9.2589 (3.6); 9.2433 (1.8); 8.0491 (0.6); 8.0056 (16.0); 7.9611 (1.6); 7.8688 (6.0); 7.8651 (6.4); 7.5149 (4.7); 7.4937 (7.0); 7.4142 (3.9); 7.4098 (3.9); 7.3931 (2.8); 7.3889 (2.8); 7.2093 (1.5); 7.1895 (4.3); 7.1696 (3.6); 7.1424 (2.2); 7.1383 (2.5); 7.1211 (3.2); 7.1041 (1.5); 7.1007 (1.3); 6.9772 (1.7); 6.9734 (1.8); 6.9579 (3.2); 6.9408 (1.7); 4.2992 (1.6); 4.2839 (1.8); 4.2650 (3.7); 4.2493 (3.6); 4.2306 (2.0); 4.2148 (1.9); 3.3147 (242.4); 2.8993 (9.2); 2.7404 (8.2); 2.5138 (22.7); 2.5094 (31.4); 2.5050 (23.7); 2.1169 (0.5); 2.1045 (1.2); 2.0963 (1.4); 2.0835 (2.5); 2.0709 (1.6); 2.0627 (1.5); 2.0499 (0.8); 1.0592 (1.5); 1.0482 (4.5); 1.0429 (5.0); 1.0325 (2.8); 1.0271 (4.8); 1.0218 (5.1); 1.0116 (2.1); 0.9955 (0.5); 0.8181 (1.9); 0.8075 (5.3); 0.8029 (5.7); 0.7950 (5.4); 0.7902 (5.8); 0.7788 (2.0)
I-608:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3503 (1.6); 9.3303 (1.7); 8.1314 (6.9); 7.9605 (2.4); 7.2505 (0.6); 7.2298 (1.6); 7.2267 (1.6); 7.2059 (1.2); 7.1720 (1.2); 7.1542 (1.6); 7.1354 (0.7); 6.9856 (0.9); 6.9823 (0.9); 6.9659 (1.6); 6.9486 (0.9); 6.8442 (5.9); 5.1522 (0.4); 5.1371 (0.9); 5.1192 (0.9); 5.1060 (0.4); 3.9017 (16.0); 3.3301 (17.0); 2.8981 (14.2); 2.7387 (13.1); 2.5520 (0.7); 2.5367 (1.7); 2.5131 (9.3); 2.5091 (12.3); 2.5053 (9.5); 2.0748 (0.5); 2.0554 (0.7); 2.0440 (0.6); 2.0357 (0.6); 1.9216 (0.4); 1.9069 (0.5); 1.8922 (0.7); 1.8694 (0.7); 1.8496 (0.8); 1.8325 (0.6); 1.8275 (0.6); 1.8169 (0.6); 1.8007 (1.0); 1.7783 (0.6); 1.7570 (0.5); 1.7415 (0.4)
I-609:1 H-NMR(300.1 MHz, CDCl3): δ= 8.2839 (16.0); 7.6294 (1.5); 7.6171 (8.8); 7.6138 (9.6); 7.6090 (4.4); 7.6040 (4.0); 7.5944 (4.6); 7.5681 (0.9); 7.3713 (3.9); 7.2691 (1.8); 7.2610 (13.7); 7.2484 (2.2); 7.2412 (2.3); 7.2315 (1.2); 7.2150 (0.3); 7.2024 (0.9); 7.1932 (6.7); 7.1647 (8.3); 6.9321 (7.5); 6.9036 (6.0); 6.6175 (3.6); 6.3717 (7.5); 6.1260 (3.8); 3.8312 (2.2); 3.8095 (5.0); 3.7898 (5.0); 3.7676 (2.4); 2.9671 (3.9); 2.9447 (7.1); 2.9224 (3.5); 0.0000 (2.4)
I-610:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7542 (0.9); 8.7511 (1.2); 8.7490 (1.2); 8.7459 (1.0); 8.7381 (1.0); 8.7349 (1.2); 8.7328 (1.2); 8.7296 (1.0); 7.8912 (0.8); 7.8854 (0.8); 7.8654 (1.6); 7.8596 (1.6); 7.8395 (1.0); 7.8337 (0.9); 7.5691 (1.1); 7.5436 (3.4); 7.5372 (2.0); 7.5194 (2.5); 7.5138 (1.9); 7.4907 (2.0); 7.4874 (1.5); 7.4831 (1.2); 7.4754 (1.6); 7.4680 (1.7); 7.4648 (2.0); 7.4613 (1.4); 7.4510 (0.9); 7.4432 (0.7); 7.4384 (1.2); 7.4347 (1.1); 7.4220 (1.1); 7.4184 (1.1); 7.4128 (1.0); 7.4091 (0.9); 7.3964 (1.0); 7.3928 (0.9); 7.2989 (3.0); 7.2353 (1.6); 7.2086 (2.0); 7.0186 (1.9); 6.9439 (1.1); 6.9172 (0.9); 6.6959 (0.5); 6.6759 (0.9); 6.6560 (0.5); 3.9897 (0.9); 3.9691 (0.8); 3.9399 (1.9); 3.9193 (1.8); 3.8901 (1.0); 3.8695 (0.9); 2.5154 (16.0); 2.3953 (5.7); 2.3881 (3.2); 2.2920 (7.7); 2.0770 (0.5); 1.8400 (7.6); 1.3029 (0.8); 1.2928 (0.7); 0.9179 (0.9); 0.8947 (0.3); 0.0363 (2.2)
I-611:1 H-NMR(300.1 MHz, CDCl3): δ= 9.7840 (0.7); 8.3739 (1.6); 8.3598 (1.7); 7.9784 (8.7); 7.7873 (0.7); 7.7822 (0.7); 7.7614 (1.5); 7.7565 (1.5); 7.7359 (0.9); 7.7307 (0.9); 7.4589 (0.8); 7.4333 (2.9); 7.4261 (2.7); 7.3985 (2.5); 7.3901 (2.6); 7.3636 (2.1); 7.2796 (2.6); 7.2603 (9.6); 7.2539 (4.0); 7.2377 (1.2); 7.2198 (1.3); 7.2141 (1.2); 7.1961 (1.0); 7.1295 (1.9); 7.1036 (1.4); 6.9939 (1.4); 6.9682 (1.4); 6.9460 (2.5); 6.8102 (3.1); 3.8291 (1.2); 3.8136 (2.2); 3.7943 (2.1); 3.7882 (2.3); 3.7732 (1.5); 3.0046 (2.4); 2.9831 (3.0); 2.9628 (2.2); 2.2310 (16.0); 0.0102 (0.4); -0.0005 (9.2)
I-612:1 H-NMR(400.1 MHz, CDCl3): δ= 8.1394 (0.8); 8.0861 (5.5); 8.0156 (0.7); 7.5346 (3.0); 7.3549 (1.2); 7.3351 (2.8); 7.3236 (7.8); 7.3159 (2.3); 7.2599 (11.0); 7.0184 (1.6); 6.9988 (1.5); 6.9697 (1.2); 6.9659 (1.4); 6.9496 (1.0); 6.9457 (1.3); 6.9116 (1.9); 6.9073 (2.5); 6.0578 (0.6); 6.0495 (0.7); 6.0409 (0.7); 6.0327 (0.6); 5.9417 (0.6); 5.9333 (0.7); 5.9248 (0.7); 5.9165 (0.6); 4.2221 (0.4); 4.2137 (0.4); 4.2058 (0.4); 4.1971 (0.4); 4.1777 (0.3); 4.1574 (0.4); 4.1490 (0.4); 4.1411 (0.4); 4.1328 (0.4); 3.8585 (0.3); 3.8450 (0.4); 3.8420 (0.4); 3.8283 (0.4); 3.8044 (0.6); 3.7900 (0.6); 3.7727 (0.4); 3.7664 (0.4); 3.7529 (0.4); 3.7499 (0.4); 2.9537 (5.1); 2.8820 (4.6); 2.7071 (16.0); 1.9560 (0.6); 1.9475 (0.7); 1.9351 (1.2); 1.9227 (0.7); 1.9141 (0.7); 1.9013 (0.3); 1.5659 (12.5); 1.0220 (0.7); 1.0101 (2.1); 1.0055 (2.3); 0.9940 (1.2); 0.9891 (2.2); 0.9845 (2.1); 0.9733 (0.9); 0.7530 (0.8); 0.7412 (2.7); 0.7374 (2.4); 0.7290 (2.3); 0.7249 (2.8); 0.7127 (0.8); -0.0002 (2.3)
I-613:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1350 (1.0); 9.0646 (0.7); 8.7270 (1.1); 8.7133 (2.4); 8.6995 (1.5); 7.9596 (2.7); 7.7713 (8.8); 7.4692 (2.2); 7.4655 (2.3); 7.4507 (2.6); 7.4469 (2.7); 7.2158 (1.2); 7.2006 (4.4); 7.1952 (5.9); 7.1758 (4.8); 7.1560 (4.4); 7.1357 (3.3); 7.1177 (1.8); 7.1136 (2.0); 7.0975 (2.3); 7.0798 (1.1); 6.9478 (0.6); 6.9293 (1.6); 6.9145 (2.5); 6.8973 (1.4); 6.8790 (0.4); 6.8632 (0.4); 6.7357 (0.5); 6.7278 (0.5); 6.7174 (0.4); 6.7080 (0.4); 3.9336 (0.6); 3.7005 (1.2); 3.6836 (3.3); 3.6678 (3.5); 3.6508 (1.6); 3.4526 (0.4); 3.4336 (0.4); 3.3398 (152.3); 3.1817 (2.6); 3.1640 (5.0); 3.1464 (2.5); 3.0761 (1.8); 2.8971 (16.0); 2.7380 (14.8); 2.7102 (0.5); 2.6819 (0.4); 2.6349 (0.4); 2.6286 (0.7); 2.5903 (24.8); 2.5804 (6.0); 2.5695 (25.3); 2.5132 (13.0); 2.5091 (17.3); 2.5050 (13.3); 2.4622 (0.5); 2.4408 (0.4); 2.0897 (0.5); 2.0770 (1.0); 2.0690 (1.3); 2.0564 (2.1); 2.0385 (3.8); 2.0231 (0.8); 1.2115 (3.4); 1.1948 (3.3); 1.1687 (0.8); 1.1518 (0.6); 1.0472 (1.2); 1.0361 (3.4); 1.0308 (4.0); 1.0205 (3.0); 1.0152 (4.2); 1.0099 (4.2); 1.0000 (2.3); 0.8011 (1.3); 0.7863 (4.8); 0.7735 (5.3); 0.7621 (2.2)
I-614:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.9844 (1.3); 8.9630 (1.4); 8.3105 (9.1); 7.8195 (0.6); 7.8062 (6.2); 7.7158 (0.6); 7.6963 (1.6); 7.6763 (1.4); 7.6352 (1.9); 7.6198 (3.2); 7.5798 (1.4); 7.5575 (1.1); 7.2449 (1.8); 7.2251 (2.0); 6.9705 (2.7); 6.9607 (1.7); 6.9404 (1.2); 5.8064 (0.6); 5.7878 (1.1); 5.7696 (0.6); 5.1621 (0.7); 5.1412 (0.7); 5.1253 (0.4); 4.6143 (1.0); 4.5956 (1.8); 4.5771 (1.0); 3.9320 (1.6); 3.9113 (1.3); 3.9041 (2.0); 3.4649 (0.4); 3.4312 (1.4); 3.4032 (1.8); 3.3954 (2.1); 3.3823 (1.9); 3.3665 (3.0); 3.3280 (1644.3); 3.2542 (0.4); 2.7435 (0.8); 2.7279 (1.5); 2.7129 (1.5); 2.6951 (0.9); 2.6808 (3.4); 2.6763 (6.6); 2.6717 (9.2); 2.6672 (6.9); 2.6628 (3.4); 2.6300 (0.6); 2.6024 (16.0); 2.5774 (0.9); 2.5420 (5.2); 2.5251 (26.6); 2.5204 (41.7); 2.5117 (519.9); 2.5073 (1040.2); 2.5027 (1366.1); 2.4981 (992.1); 2.4936 (483.4); 2.3855 (0.4); 2.3386 (2.8); 2.3341 (6.0); 2.3296 (8.3); 2.3251 (6.2); 2.3206 (2.9); 2.0726 (1.3); 2.0111 (0.4); 1.9975 (0.5); 1.9782 (0.7); 1.9540 (0.4); 1.8644 (0.6); 1.8463 (0.5); 1.7918 (0.4); 1.7640 (0.9); 1.7486 (1.3); 1.7239 (0.9); 1.7056 (0.5); 1.6205 (1.9); 1.6098 (3.3); 1.6018 (3.0); 1.2369 (0.4); -0.0002 (4.1)
I-615:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2791 (9.2); 7.9294 (1.1); 7.6520 (0.3); 7.6317 (4.6); 7.6188 (5.5); 7.4741 (3.1); 7.4546 (0.4); 7.4446 (1.2); 7.4382 (1.2); 7.4332 (1.7); 7.4284 (1.5); 7.4221 (1.1); 7.4159 (0.8); 7.3317 (2.0); 7.3121 (2.3); 7.2588 (7.9); 7.2249 (1.8); 7.2063 (2.2); 7.0643 (1.5); 7.0450 (2.3); 7.0258 (1.0); 5.2968 (0.4); 4.2878 (1.5); 4.2731 (1.5); 4.2516 (3.1); 4.2368 (3.0); 4.2153 (1.6); 4.2005 (1.5); 2.3986 (10.6); 2.3357 (0.4); 2.2983 (16.0); 1.5505 (3.5); 1.4318 (0.6); -0.0002 (5.1)
I-616:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3064 (16.0); 8.0379 (1.1); 8.0177 (1.8); 8.0002 (1.1); 7.6692 (1.6); 7.6431 (4.3); 7.6167 (3.2); 7.5568 (3.9); 7.5233 (6.1); 7.4940 (10.8); 7.4387 (10.2); 7.4164 (6.2); 7.4114 (6.6); 7.3810 (2.8); 7.3542 (2.3); 7.3051 (19.8); 6.9391 (2.9); 6.7516 (5.8); 6.5642 (2.9); 4.2749 (2.7); 4.2547 (2.7); 4.2274 (5.8); 4.2072 (5.6); 4.1798 (3.1); 4.1597 (2.8); 2.0893 (2.5); 1.6006 (8.8); 1.3271 (0.8); 1.3032 (2.0); 1.2795 (0.8); 0.0544 (0.6); 0.0437 (19.3); 0.0329 (0.8)
I-617:1 H-NMR(400.1 MHz, CDCl3): δ= 8.3208 (9.4); 8.0174 (1.9); 7.8615 (1.0); 7.8432 (1.0); 7.6057 (0.3); 7.5848 (3.1); 7.5792 (2.5); 7.5724 (6.0); 7.5707 (6.1); 7.4900 (3.2); 7.4719 (0.4); 7.4614 (1.3); 7.4516 (1.7); 7.4466 (1.6); 7.4390 (1.2); 7.4326 (0.8); 7.2594 (13.3); 6.4313 (4.3); 5.3783 (1.0); 5.3606 (1.1); 2.9559 (14.0); 2.8832 (12.8); 2.6174 (0.6); 2.5753 (2.3); 2.5666 (2.2); 2.3925 (16.0); 2.3102 (0.4); 2.2949 (0.5); 2.2817 (1.0); 2.2713 (1.0); 2.2628 (0.8); 2.2497 (0.7); 1.8981 (0.9); 1.8905 (0.9); 1.8823 (1.4); 1.8745 (2.3); 1.8615 (3.8); 1.8493 (2.2); 1.8386 (1.0); 1.8327 (0.7); 1.6637 (0.3); 1.4318 (1.8); -0.0002 (3.8)
I-618:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2630 (5.2); 8.0506 (0.7); 7.6664 (1.9); 7.4898 (1.3); 7.4617 (3.1); 7.4557 (1.4); 7.4279 (3.8); 7.4006 (2.0); 7.2988 (20.8); 6.9523 (1.1); 6.9468 (1.2); 6.9236 (0.9); 6.9192 (1.0); 6.8214 (1.0); 6.8165 (1.2); 6.7871 (2.8); 6.7791 (2.3); 6.7719 (1.0); 5.3381 (1.0); 4.4814 (1.0); 4.4607 (1.0); 4.4336 (2.0); 4.4132 (2.0); 4.3859 (1.0); 4.3654 (1.0); 3.8783 (16.0); 1.5829 (13.8); 0.0384 (20.8); 0.0275 (1.2)
I-619:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1910 (2.2); 9.1767 (4.4); 9.1621 (2.5); 8.1160 (16.0); 7.9606 (2.6); 7.7601 (9.2); 7.6298 (6.3); 7.6093 (5.0); 7.5368 (2.2); 7.5144 (8.0); 7.5005 (11.7); 7.4760 (6.6); 7.4549 (2.6); 7.4346 (3.3); 7.3524 (0.5); 7.3344 (0.7); 7.2996 (6.5); 7.1646 (3.2); 6.0634 (1.4); 6.0518 (2.4); 6.0390 (1.6); 5.9486 (1.4); 5.9360 (2.3); 5.9236 (1.7); 3.9544 (0.3); 3.9400 (0.6); 3.9203 (1.2); 3.9032 (2.6); 3.8864 (3.1); 3.8737 (1.7); 3.8620 (1.9); 3.8468 (2.7); 3.8397 (2.2); 3.8293 (2.6); 3.8152 (1.5); 3.7898 (0.6); 3.7805 (0.4); 3.5862 (0.5); 3.5709 (0.6); 3.3257 (221.2); 2.9802 (0.4); 2.9639 (0.8); 2.9460 (0.4); 2.8989 (13.1); 2.7396 (12.4); 2.5099 (30.7); 1.2428 (0.4)
I-620:1 H-NMR(400.1 MHz, CDCl3): δ= 8.1144 (0.5); 8.1007 (0.8); 8.0872 (0.5); 8.0467 (5.4); 8.0158 (0.7); 7.4959 (2.2); 7.4746 (2.6); 7.4615 (2.4); 7.4592 (2.5); 7.3485 (1.2); 7.3287 (2.6); 7.3090 (1.5); 7.2599 (10.4); 7.2032 (1.4); 7.1986 (1.4); 7.1821 (1.2); 7.1775 (1.2); 7.0159 (1.6); 6.9964 (1.5); 6.9483 (1.2); 6.9442 (1.4); 6.9280 (1.0); 6.9241 (1.3); 6.8921 (1.9); 6.8878 (2.5); 4.4270 (1.0); 4.4116 (1.0); 4.3915 (2.2); 4.3761 (2.1); 4.3560 (1.1); 4.3406 (1.1); 2.9536 (4.8); 2.8820 (4.4); 2.6994 (16.0); 1.9520 (0.6); 1.9435 (0.7); 1.9310 (1.2); 1.9187 (0.7); 1.9102 (0.7); 1.8975 (0.3); 1.5639 (14.2); 1.0247 (0.7); 1.0128 (2.1); 1.0082 (2.2); 0.9967 (1.2); 0.9918 (2.2); 0.9873 (2.0); 0.9760 (0.8); 0.7506 (0.8); 0.7388 (2.7); 0.7350 (2.4); 0.7265 (2.3); 0.7224 (2.7); 0.7102 (0.7); -0.0002 (2.2)
I-621:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 18.0412 (0.4); 12.9947 (0.4); 9.0609 (0.4); 9.0373 (1.2); 9.0148 (1.2); 8.9328 (0.4); 8.3118 (12.8); 7.8228 (5.3); 7.8004 (1.3); 7.7185 (0.6); 7.6981 (1.6); 7.6784 (1.4); 7.6380 (2.0); 7.6201 (3.6); 7.5984 (0.4); 7.5786 (1.4); 7.5556 (1.1); 7.5054 (0.4); 7.4913 (0.5); 7.3341 (2.3); 7.2652 (0.4); 7.2467 (6.0); 7.2219 (0.4); 7.2053 (0.4); 7.1791 (0.6); 7.1584 (0.6); 6.8050 (0.6); 6.7594 (0.4); 6.7347 (0.4); 5.8070 (0.5); 5.7873 (0.9); 5.7699 (0.5); 5.1415 (0.8); 5.1304 (0.8); 4.6139 (0.7); 4.5953 (1.4); 4.5770 (0.7); 3.7732 (0.4); 3.7295 (0.3); 3.7272 (0.4); 3.6934 (0.4); 3.6535 (0.4); 3.6170 (0.4); 3.5981 (0.4); 3.5741 (0.4); 3.5552 (0.5); 3.5369 (0.4); 3.5328 (0.5); 3.5072 (0.6); 3.4485 (0.9); 3.4375 (1.0); 3.3278 (2945.9); 3.2506 (0.4); 2.8560 (0.4); 2.7548 (1.4); 2.7388 (1.5); 2.6804 (5.9); 2.6761 (11.7); 2.6715 (16.0); 2.6670 (11.7); 2.6625 (7.2); 2.6071 (14.1); 2.6011 (5.0); 2.5418 (9.0); 2.5249 (59.1); 2.5201 (92.8); 2.5116 (978.3); 2.5071 (1927.0); 2.5026 (2503.5); 2.4980 (1809.5); 2.4935 (874.0); 2.4078 (0.8); 2.3720 (0.4); 2.3460 (0.8); 2.3385 (5.2); 2.3339 (11.0); 2.3294 (15.2); 2.3249 (11.1); 2.3205 (5.1); 2.2783 (0.4); 2.0729 (2.0); 2.0211 (0.4); 1.9947 (0.6); 1.9819 (0.8); 1.9753 (0.8); 1.8874 (0.5); 1.8572 (0.6); 1.8423 (0.7); 1.7968 (0.5); 1.7723 (0.9); 1.7555 (1.2); 1.7330 (1.0); 1.7083 (0.4); 1.2363 (0.6); 1.0450 (0.5); 0.8919 (0.6); 0.8706 (0.8); 0.8336 (0.4); 0.5697 (0.5); 0.5536 (0.4); -0.0002 (8.0); -3.0487 (0.3); -3.4068 (0.4); -3.4863 (0.4)
I-622:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2769 (4.2); 7.8853 (0.6); 7.6237 (2.6); 7.6109 (2.4); 7.4594 (1.5); 7.4063 (0.6); 7.4001 (0.7); 7.3935 (0.8); 7.3886 (0.7); 7.3840 (0.5); 7.3776 (0.4); 7.2645 (1.9); 7.2589 (3.0); 7.2363 (0.8); 7.2167 (1.0); 7.1271 (1.4); 7.1077 (1.0); 5.2961 (0.8); 4.2114 (0.8); 4.1967 (0.7); 4.1760 (1.6); 4.1613 (1.5); 4.1405 (0.8); 4.1258 (0.8); 2.2300 (16.0); 1.5560 (2.1); -0.0002 (1.6)
I-623:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2976 (1.2); 9.2821 (2.7); 9.2667 (1.5); 8.8576 (6.8); 8.7218 (3.5); 8.7096 (3.6); 8.1505 (7.2); 8.0325 (0.7); 7.9605 (3.2); 7.7307 (3.6); 7.7185 (3.5); 7.5203 (0.6); 7.4993 (1.4); 7.4776 (1.6); 7.4561 (0.9); 7.4112 (0.6); 7.3908 (1.5); 7.3758 (1.7); 7.3469 (4.3); 7.3275 (5.2); 7.3078 (1.0); 7.0855 (4.7); 6.9601 (2.5); 6.9403 (2.4); 4.1689 (1.1); 4.1534 (1.2); 4.1325 (2.5); 4.1169 (2.4); 4.0962 (1.4); 4.0805 (1.4); 3.3234 (132.3); 2.8985 (14.7); 2.7395 (14.3); 2.5103 (17.0); 2.5084 (16.9); 2.4423 (11.3); 2.2832 (0.4); 2.2174 (16.0); 2.1823 (0.5)
I-624:1 H-NMR(300.1 MHz, CDCl3): δ= 8.2931 (10.0); 7.6415 (1.0); 7.6265 (1.0); 7.6089 (4.6); 7.6058 (5.8); 7.5851 (2.5); 7.5589 (0.6); 7.3482 (2.7); 7.2812 (1.1); 7.2744 (1.5); 7.2587 (7.7); 7.2524 (1.8); 7.2430 (0.7); 6.9848 (2.5); 6.9601 (2.9); 6.6948 (5.9); 6.6684 (1.6); 4.3049 (0.3); 3.8812 (1.4); 3.8593 (3.4); 3.8399 (3.3); 3.8178 (1.6); 3.1433 (2.6); 3.1208 (4.8); 3.0985 (2.3); 2.1490 (16.0); 1.9551 (0.3); 1.9369 (0.8); 1.9270 (0.8); 1.9192 (0.5); 1.9091 (1.5); 1.8987 (0.5); 1.8912 (0.9); 1.8811 (0.8); 1.8633 (0.4); 1.5810 (2.7); 0.9608 (0.6); 0.9475 (1.2); 0.9329 (2.9); 0.9267 (3.0); 0.9198 (1.8); 0.9126 (1.7); 0.9046 (3.1); 0.8983 (3.0); 0.8847 (1.4); 0.6423 (1.3); 0.6281 (3.0); 0.6226 (3.6); 0.6101 (3.1); 0.6045 (3.3); 0.5894 (1.0); -0.0005 (6.3)
I-625:1 H-NMR(400.1 MHz, CDCl3): δ= 8.1607 (0.9); 8.0802 (5.5); 8.0159 (0.5); 7.3390 (1.3); 7.3276 (2.2); 7.3193 (2.8); 7.3076 (2.4); 7.2996 (1.7); 7.2591 (9.3); 7.0227 (2.6); 7.0108 (1.8); 6.9910 (1.5); 6.9736 (1.2); 6.9691 (1.4); 6.9534 (1.0); 6.9489 (1.3); 6.9325 (1.4); 6.9117 (1.4); 6.9050 (2.2); 6.9003 (2.6); 4.2363 (1.0); 4.2215 (1.0); 4.2002 (2.2); 4.1853 (2.2); 4.1642 (1.1); 4.1493 (1.1); 2.9532 (3.6); 2.8819 (3.3); 2.7000 (16.0); 2.4730 (7.0); 2.2839 (9.9); 1.9475 (0.6); 1.9390 (0.7); 1.9266 (1.2); 1.9142 (0.7); 1.9056 (0.7); 1.8929 (0.3); 1.5647 (12.6); 1.0170 (0.7); 1.0053 (2.1); 1.0005 (2.2); 0.9890 (1.1); 0.9842 (2.2); 0.9796 (2.1); 0.9684 (0.8); 0.7469 (0.8); 0.7351 (2.7); 0.7313 (2.4); 0.7229 (2.3); 0.7188 (2.8); 0.7066 (0.7); -0.0002 (2.0)
I-626:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2518 (1.6); 9.2305 (1.7); 8.2194 (6.9); 7.9606 (2.0); 7.4938 (2.8); 7.3621 (1.4); 7.3575 (1.4); 7.3417 (1.7); 7.3369 (1.6); 7.2456 (0.6); 7.2244 (1.6); 7.2215 (1.5); 7.2035 (1.2); 7.2007 (1.3); 7.1694 (1.2); 7.1515 (1.6); 7.1329 (0.7); 7.1071 (2.4); 7.0866 (2.1); 6.9932 (0.9); 6.9898 (0.9); 6.9735 (1.6); 6.9563 (0.9); 5.1987 (0.3); 5.1794 (0.9); 5.1638 (0.9); 3.8997 (16.0); 3.3299 (18.4); 2.8981 (12.1); 2.7387 (11.8); 2.7234 (2.1); 2.7172 (2.0); 2.5131 (9.6); 2.5091 (12.6); 2.5050 (9.6); 2.0585 (0.4); 2.0333 (0.7); 2.0184 (0.6); 2.0013 (0.6); 1.9162 (0.4); 1.8900 (0.8); 1.8741 (0.5); 1.8578 (0.3); 1.7936 (1.4); 1.7769 (1.5); 1.7526 (0.9)
I-627:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2782 (11.7); 8.0189 (2.3); 7.6270 (6.0); 7.6141 (6.4); 7.4771 (3.6); 7.4521 (0.4); 7.4422 (1.4); 7.4362 (1.4); 7.4300 (2.1); 7.4254 (1.8); 7.4197 (1.3); 7.4135 (0.9); 7.2588 (36.8); 6.7863 (4.0); 6.7152 (2.0); 6.6827 (2.0); 4.3403 (1.2); 4.3372 (1.2); 4.3251 (1.2); 4.3220 (1.2); 4.3046 (2.4); 4.3014 (2.4); 4.2893 (2.4); 4.2861 (2.3); 4.2655 (1.2); 4.2532 (1.2); 4.2503 (1.2); 2.9554 (7.9); 2.8835 (7.1); 2.4493 (5.2); 2.4390 (10.3); 2.4287 (5.4); 2.3070 (0.5); 2.2649 (16.0); 1.5519 (3.4); 1.4318 (3.1); 0.0079 (0.4); -0.0002 (10.4)
I-628:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.9831 (1.5); 8.9700 (1.5); 7.9548 (0.3); 7.8068 (6.5); 7.7291 (0.5); 7.7091 (1.6); 7.6893 (2.7); 7.6685 (1.8); 7.6528 (1.8); 7.6342 (3.5); 7.6027 (1.6); 7.5820 (2.1); 7.5585 (1.1); 7.4235 (1.0); 7.4043 (1.6); 7.3852 (0.7); 7.3186 (1.7); 7.2989 (1.5); 3.3310 (24.1); 3.3119 (0.9); 3.3062 (0.8); 3.3022 (0.8); 3.2926 (0.7); 2.8915 (2.2); 2.7330 (1.9); 2.6120 (16.0); 2.5263 (0.4); 2.5127 (9.1); 2.5084 (18.8); 2.5039 (24.8); 2.4993 (17.6); 2.4949 (8.3); 2.3216 (0.4); 2.2997 (0.7); 1.4188 (1.2); 1.4126 (1.1); 1.3996 (2.3); 1.3889 (1.2); 1.3840 (1.1); 1.3759 (1.2); 1.2398 (0.5); -0.0002 (4.2)
I-629:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2965 (2.3); 7.5863 (0.8); 7.5825 (0.8); 7.4592 (0.4); 7.4316 (0.8); 7.4046 (0.5); 7.3732 (2.1); 7.3699 (2.1); 7.2987 (15.1); 6.9540 (0.3); 6.9483 (0.4); 6.8373 (0.3); 6.8325 (0.4); 6.8299 (0.4); 6.8060 (0.5); 6.8031 (0.4); 6.7978 (0.6); 6.7903 (0.8); 6.7828 (0.3); 5.3380 (2.1); 3.8786 (6.3); 2.0835 (0.7); 1.5804 (16.0); 1.2978 (0.4); 0.0491 (0.5); 0.0383 (14.4); 0.0306 (0.4); 0.0275 (0.5)
I-630:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3183 (1.0); 9.3027 (2.2); 9.2866 (1.1); 8.0543 (9.3); 7.9605 (2.6); 7.9441 (0.5); 7.8648 (3.9); 7.8022 (0.9); 7.6427 (1.0); 7.6256 (1.9); 7.6095 (2.3); 7.5884 (2.0); 7.5694 (1.3); 7.5203 (2.6); 7.4989 (5.4); 7.4760 (2.6); 7.4562 (1.2); 7.4373 (4.0); 7.4160 (1.7); 7.4118 (1.7); 7.3026 (3.3); 7.2885 (0.5); 7.1676 (1.6); 4.3057 (0.9); 4.2902 (1.1); 4.2716 (2.2); 4.2558 (2.3); 4.2374 (1.4); 4.2214 (1.2); 3.3245 (151.7); 2.8987 (16.0); 2.7395 (14.5); 2.5137 (11.8); 2.5094 (16.3); 2.5052 (12.7)
I-631:1 H-NMR(300.1 MHz, CDCl3): δ= 8.2775 (9.6); 7.6204 (0.4); 7.6067 (4.6); 7.6036 (5.6); 7.5943 (2.3); 7.5834 (3.0); 7.5573 (1.2); 7.3562 (2.7); 7.3033 (1.1); 7.2964 (1.4); 7.2817 (1.4); 7.2745 (1.6); 7.2603 (7.8); 7.1405 (3.1); 7.0826 (2.6); 7.0566 (3.5); 6.9199 (1.8); 6.9161 (1.8); 6.8940 (1.4); 6.8901 (1.3); 3.8851 (1.4); 3.8659 (3.2); 3.8428 (3.0); 3.8240 (1.6); 3.1331 (9.8); 3.1082 (3.8); 3.0877 (2.4); 2.1523 (16.0); 1.5926 (0.5); 1.2535 (0.4); 0.0102 (0.3); -0.0005 (7.7)
I-632:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0827 (5.3); 8.0369 (0.9); 8.0165 (1.6); 7.5381 (3.0); 7.3761 (0.7); 7.3552 (4.2); 7.3488 (3.0); 7.3451 (2.7); 7.3277 (0.5); 7.3240 (0.5); 7.2605 (11.5); 7.1379 (0.4); 7.1243 (2.6); 7.1177 (2.2); 7.1060 (3.6); 6.8585 (0.7); 6.8516 (0.7); 6.8422 (1.2); 6.8336 (1.0); 6.8183 (0.6); 6.0743 (0.6); 6.0661 (0.6); 6.0582 (0.6); 6.0499 (0.6); 5.9585 (0.6); 5.9503 (0.6); 5.9424 (0.6); 5.9340 (0.6); 4.2270 (0.4); 4.2187 (0.4); 4.2109 (0.4); 4.2020 (0.6); 4.1647 (0.4); 4.1563 (0.4); 4.1486 (0.4); 4.1403 (0.3); 3.9170 (0.3); 3.9016 (0.5); 3.8872 (0.4); 3.8649 (0.4); 3.8593 (0.4); 3.8506 (0.3); 3.8450 (0.5); 3.8292 (0.4); 3.8227 (0.3); 3.8083 (0.4); 2.9540 (9.4); 2.8821 (8.6); 2.7091 (16.0); 2.1292 (0.6); 2.1209 (0.6); 2.1080 (1.1); 2.0953 (0.7); 2.0870 (0.6); 1.5722 (12.5); 1.0526 (0.7); 1.0409 (2.0); 1.0363 (2.1); 1.0251 (1.1); 1.0197 (2.1); 1.0151 (2.0); 1.0041 (0.8); 0.8022 (0.8); 0.7905 (2.5); 0.7871 (2.4); 0.7780 (2.2); 0.7741 (2.5); 0.7619 (0.7); -0.0002 (2.5)
I-633:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.4382 (2.3); 9.4230 (4.1); 9.4076 (1.9); 8.1765 (1.8); 8.1679 (16.0); 8.0474 (6.4); 8.0432 (6.4); 7.8772 (0.4); 7.8547 (0.5); 7.8188 (0.3); 7.7761 (3.0); 7.7715 (2.9); 7.7540 (3.9); 7.7502 (3.8); 7.7383 (1.9); 7.7176 (4.9); 7.6984 (11.1); 7.6761 (6.1); 7.6566 (2.8); 7.6385 (4.6); 7.6239 (6.5); 7.6039 (3.5); 4.2741 (2.0); 4.2492 (4.6); 4.2329 (4.4); 4.2240 (2.8); 4.2079 (2.1); 3.3397 (320.9); 3.3357 (269.2); 3.3326 (262.3); 2.7123 (0.5); 2.6717 (1.3); 2.5425 (123.6); 2.5073 (191.6); 2.5032 (245.2); 2.4990 (182.5); 2.3746 (0.5); 2.3692 (0.7); 2.3304 (1.4); 1.2595 (0.4); -0.0002 (6.0)
I-634:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.6762 (2.9); 7.7245 (0.6); 7.7049 (1.8); 7.6850 (1.5); 7.6550 (7.2); 7.6384 (1.0); 7.5387 (2.4); 7.4981 (1.3); 7.4781 (1.1); 7.2670 (3.6); 7.2462 (4.7); 7.1128 (5.1); 7.0919 (4.0); 3.3258 (20.9); 2.9047 (6.3); 2.8924 (0.9); 2.7332 (0.5); 2.5694 (16.0); 2.5075 (18.6); 2.5030 (24.5); 2.4986 (17.8); 1.2402 (0.5); 0.8869 (1.0); 0.8692 (3.4); 0.8578 (1.5); 0.7578 (1.4); 0.7463 (3.2); 0.7429 (3.2); 0.7292 (0.9); -0.0002 (4.0)
I-635:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.8172 (0.8); 8.8031 (1.7); 8.7887 (0.8); 8.7140 (16.0); 8.0877 (8.6); 7.7425 (0.7); 7.7229 (2.2); 7.7032 (2.3); 7.6894 (2.7); 7.6697 (1.0); 7.6321 (3.1); 7.5536 (1.7); 7.5341 (1.4); 3.8026 (1.2); 3.7862 (3.2); 3.7708 (3.3); 3.7546 (1.3); 3.3452 (28.9); 3.3431 (27.8); 3.1879 (2.4); 3.1712 (5.0); 3.1543 (2.2); 2.8933 (1.3); 2.7340 (1.2); 2.5146 (6.0); 2.5106 (12.6); 2.5062 (16.9); 2.5017 (12.4); 2.4975 (6.2); 1.2388 (0.5); -0.0002 (1.7)
I-636:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9165 (0.4); 7.8969 (0.8); 7.8774 (0.4); 7.5524 (0.4); 7.5274 (1.2); 7.5023 (2.6); 7.4965 (2.2); 7.4915 (1.6); 7.4621 (1.9); 7.4595 (1.8); 7.4402 (2.6); 7.4279 (0.8); 7.4129 (2.4); 7.2986 (3.3); 7.0883 (2.0); 7.0431 (1.1); 7.0164 (0.9); 4.2751 (0.8); 4.2549 (0.8); 4.2249 (1.8); 4.2047 (1.8); 4.1746 (0.9); 4.1545 (0.9); 3.8427 (1.5); 3.8233 (3.1); 3.8039 (1.7); 3.3951 (0.6); 3.3837 (16.0); 3.1578 (1.6); 3.1384 (2.8); 3.1190 (1.4); 2.5442 (5.8); 2.5374 (3.5); 2.3196 (7.7); 2.1111 (0.5); 2.1002 (0.6); 2.0953 (0.4); 2.0841 (1.1); 2.0730 (0.4); 2.0679 (0.6); 2.0570 (0.6); 1.6344 (3.0); 1.3465 (0.6); 1.3323 (1.8); 1.3237 (2.1); 1.3165 (1.9); 1.3077 (2.0); 1.2954 (1.2); 1.2684 (3.6); 1.2560 (0.6); 1.1083 (0.7); 1.0961 (1.8); 1.0871 (1.6); 1.0815 (1.1); 1.0691 (1.8); 1.0601 (1.6); 1.0463 (0.6); 0.1098 (8.4); 0.0977 (0.3); 0.0376 (2.7)
I-637:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1906 (1.9); 9.1762 (3.9); 9.1614 (2.1); 8.1165 (12.5); 7.9605 (3.3); 7.6453 (8.9); 7.6293 (5.4); 7.6093 (4.0); 7.5787 (4.9); 7.5577 (6.1); 7.4927 (3.0); 7.4728 (4.4); 7.4528 (2.0); 7.4324 (2.6); 7.4055 (4.3); 7.3846 (3.5); 7.2974 (5.3); 7.1624 (2.6); 6.0786 (1.2); 6.0664 (2.0); 6.0545 (1.3); 5.9637 (1.1); 5.9509 (1.9); 5.9387 (1.3); 3.9442 (0.5); 3.9234 (1.0); 3.9073 (2.1); 3.8901 (2.6); 3.8758 (1.4); 3.8668 (1.5); 3.8519 (2.3); 3.8337 (2.0); 3.8187 (1.2); 3.8073 (0.5); 3.7931 (0.5); 3.3231 (174.1); 2.8988 (16.0); 2.7397 (15.5); 2.5104 (22.4); 1.2461 (0.4)
I-638:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0377 (5.4); 8.0158 (1.0); 7.9923 (0.6); 7.9781 (0.9); 7.9647 (0.5); 7.5323 (2.3); 7.5111 (2.6); 7.4588 (2.6); 7.2602 (10.5); 7.2150 (1.5); 7.2106 (1.4); 7.1939 (1.3); 7.1895 (1.2); 7.1137 (3.7); 7.1003 (3.2); 7.0801 (0.4); 6.8557 (0.7); 6.8428 (1.1); 6.8323 (1.2); 6.8217 (0.7); 6.8155 (0.6); 4.4513 (1.1); 4.4358 (1.1); 4.4165 (2.2); 4.4010 (2.2); 4.3817 (1.2); 4.3663 (1.1); 2.9538 (6.2); 2.8820 (5.8); 2.6989 (16.0); 2.1248 (0.6); 2.1166 (0.6); 2.1037 (1.2); 2.0909 (0.7); 2.0825 (0.6); 1.5681 (10.0); 1.0574 (0.7); 1.0454 (2.1); 1.0408 (2.2); 1.0293 (1.2); 1.0242 (2.2); 1.0196 (2.1); 1.0085 (0.8); 0.8028 (0.8); 0.7908 (2.7); 0.7876 (2.5); 0.7784 (2.4); 0.7745 (2.6); 0.7622 (0.7); -0.0002 (2.2)
I-639:1 H-NMR(400.1 MHz, CDCl3): δ= 8.3035 (16.0); 8.1249 (1.5); 7.6989 (2.4); 7.6789 (2.4); 7.6409 (0.4); 7.6189 (1.8); 7.6004 (7.1); 7.5945 (6.4); 7.5864 (12.4); 7.5737 (1.7); 7.5424 (1.0); 7.4791 (7.1); 7.4571 (0.6); 7.4312 (0.7); 7.4203 (2.4); 7.4113 (3.4); 7.4062 (3.4); 7.3982 (2.6); 7.3921 (1.7); 7.2606 (7.0); 6.7517 (13.5); 5.2963 (0.4); 5.2784 (1.2); 5.2618 (2.6); 5.2450 (2.5); 5.2283 (1.1); 2.7679 (0.4); 2.7534 (0.7); 2.7262 (2.2); 2.7122 (5.6); 2.6978 (5.7); 2.6848 (2.2); 2.6564 (0.6); 2.2380 (0.7); 2.2257 (1.2); 2.2194 (1.3); 2.2156 (1.3); 2.2065 (1.9); 2.1973 (1.8); 2.1849 (1.8); 2.1776 (1.3); 2.1720 (1.2); 2.1641 (0.9); 1.9610 (1.1); 1.9375 (2.8); 1.9311 (3.4); 1.9229 (4.0); 1.9173 (3.5); 1.9109 (3.0); 1.9038 (2.6); 1.8886 (1.2); 1.8769 (0.6); 1.8643 (1.4); 1.8574 (1.4); 1.8476 (1.5); 1.8408 (1.8); 1.8325 (1.5); 1.8228 (1.5); 1.8156 (1.5); 1.8051 (1.2); 1.7956 (0.8); 1.7858 (0.6); 1.5787 (1.7); 1.2558 (1.0); -0.0002 (3.8)
I-640:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2651 (16.0); 8.1173 (1.2); 8.0984 (2.0); 8.0800 (1.2); 7.6755 (5.7); 7.4919 (3.3); 7.4636 (8.5); 7.4305 (6.9); 7.4039 (8.0); 7.3774 (3.9); 7.3045 (39.0); 7.1008 (3.8); 7.0746 (3.2); 7.0119 (2.7); 7.0087 (2.7); 7.0039 (3.3); 6.9849 (2.2); 6.9818 (2.3); 6.9770 (3.2); 6.9437 (4.6); 6.9380 (5.5); 6.9312 (2.9); 5.3441 (10.2); 4.4823 (2.5); 4.4618 (2.5); 4.4345 (5.4); 4.4140 (5.2); 4.3867 (2.7); 4.3663 (2.6); 2.0325 (0.6); 2.0161 (1.3); 2.0048 (1.5); 1.9882 (2.8); 1.9714 (1.6); 1.9601 (1.5); 1.9433 (0.8); 1.5917 (19.4); 1.3001 (0.4); 1.0999 (1.8); 1.0846 (4.9); 1.0777 (5.4); 1.0624 (3.1); 1.0562 (5.3); 1.0499 (4.7); 1.0348 (2.3); 1.0129 (0.3); 0.8098 (2.2); 0.7942 (6.4); 0.7889 (5.2); 0.7777 (5.2); 0.7723 (6.4); 0.7557 (1.8); 0.1133 (0.5); 0.0544 (1.4); 0.0436 (40.2); 0.0326 (1.5)
I-641:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.6706 (2.6); 7.9528 (0.7); 7.7298 (0.5); 7.7101 (1.6); 7.6903 (1.3); 7.6608 (1.8); 7.6522 (5.2); 7.6420 (0.9); 7.5709 (2.1); 7.5249 (1.2); 7.5046 (0.9); 7.1563 (3.2); 7.1349 (3.5); 6.6423 (3.7); 6.6209 (3.4); 3.5998 (16.0); 3.3273 (21.1); 2.8906 (4.6); 2.8443 (5.3); 2.7317 (4.1); 2.5685 (13.1); 2.5063 (16.6); 2.5021 (21.5); 2.4977 (15.5); 1.2400 (0.6); 0.8332 (0.8); 0.8154 (2.9); 0.8044 (1.2); 0.7244 (1.2); 0.7132 (2.8); 0.6960 (0.8); -0.0002 (3.0)
I-642:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5690 (2.1); 7.5517 (1.4); 7.5404 (2.8); 7.5284 (4.1); 7.5176 (2.3); 7.5111 (2.3); 7.4256 (1.9); 7.3883 (0.8); 7.3803 (1.4); 7.3731 (0.8); 7.3670 (0.5); 7.3642 (0.5); 7.3580 (0.8); 7.3505 (0.5); 7.2985 (2.6); 7.2209 (1.3); 7.2142 (1.2); 7.1927 (1.1); 7.1860 (1.0); 6.5181 (0.5); 6.4968 (1.0); 6.4755 (0.5); 4.4583 (0.9); 4.4368 (0.9); 4.4101 (2.0); 4.3886 (1.9); 4.3619 (1.0); 4.3404 (0.9); 2.4143 (16.0); 2.0930 (0.6); 2.0823 (0.6); 2.0764 (0.4); 2.0661 (1.3); 2.0550 (0.5); 2.0494 (0.7); 2.0387 (0.7); 2.0222 (0.3); 1.6457 (1.2); 1.3015 (1.0); 1.2948 (0.9); 1.2517 (6.6); 1.2373 (0.7); 1.2218 (1.8); 1.2138 (2.2); 1.2057 (1.8); 1.2024 (1.6); 1.1975 (2.0); 1.1858 (0.9); 1.0981 (0.9); 1.0865 (2.0); 1.0780 (1.5); 1.0712 (1.2); 1.0594 (1.9); 1.0507 (1.5); 1.0358 (0.6); 0.9382 (0.3); 0.9166 (1.0); 0.8932 (0.4); 0.1079 (1.0); 0.0349 (2.1)
I-643:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1089 (1.3); 9.0947 (2.8); 9.0805 (1.6); 8.8573 (8.1); 8.7191 (4.2); 8.7067 (4.7); 8.2389 (9.1); 8.0898 (0.8); 7.9606 (3.0); 7.8008 (0.9); 7.7717 (4.8); 7.7630 (4.1); 7.7409 (4.1); 7.7315 (5.4); 7.7193 (5.9); 7.6864 (3.2); 7.6665 (2.1); 7.6340 (5.1); 7.6113 (0.5); 7.5870 (3.7); 7.5660 (4.5); 7.5503 (0.7); 7.3690 (2.5); 7.3645 (2.9); 7.3483 (2.3); 7.3438 (2.5); 6.1030 (0.8); 6.0906 (1.5); 6.0783 (0.9); 5.9878 (0.7); 5.9757 (1.5); 5.9632 (0.9); 3.9395 (1.9); 3.9250 (1.4); 3.8977 (1.3); 3.8828 (2.1); 3.8681 (1.4); 3.8410 (0.4); 3.3320 (171.7); 2.8989 (16.0); 2.7394 (15.0); 2.5102 (21.6)
I-644:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0752 (5.4); 8.0306 (1.0); 8.0162 (1.1); 7.3498 (2.1); 7.3299 (2.3); 7.2594 (9.7); 7.1037 (3.5); 7.0908 (2.6); 7.0856 (2.7); 7.0710 (0.5); 7.0157 (2.5); 6.9290 (1.3); 6.9091 (1.3); 6.8487 (0.7); 6.8335 (1.1); 6.8249 (1.3); 6.8156 (0.7); 6.8085 (0.6); 4.2536 (1.0); 4.2387 (1.0); 4.2180 (2.2); 4.2030 (2.2); 4.1823 (1.2); 4.1674 (1.1); 2.9533 (4.1); 2.8820 (3.8); 2.7012 (16.0); 2.4777 (7.0); 2.2632 (9.8); 2.1247 (0.6); 2.1164 (0.6); 2.1036 (1.2); 2.0907 (0.7); 2.0825 (0.7); 2.0693 (0.4); 1.5662 (8.8); 1.0492 (0.7); 1.0374 (2.1); 1.0326 (2.2); 1.0213 (1.2); 1.0162 (2.2); 1.0115 (2.1); 1.0004 (0.9); 0.7982 (0.8); 0.7864 (2.6); 0.7828 (2.4); 0.7740 (2.3); 0.7699 (2.7); 0.7577 (0.8); -0.0002 (2.1)
I-645:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3699 (3.6); 7.3432 (4.1); 7.2986 (29.1); 7.1663 (0.6); 7.1042 (1.2); 7.0757 (3.2); 7.0608 (3.0); 7.0524 (7.7); 7.0383 (6.2); 7.0324 (6.9); 7.0119 (1.8); 7.0049 (1.4); 6.9240 (2.1); 6.8979 (1.9); 6.8248 (1.3); 6.8149 (1.3); 6.8026 (2.4); 6.7951 (1.9); 6.7773 (1.2); 6.7712 (1.1); 4.2508 (2.0); 4.2307 (1.9); 4.2026 (4.2); 4.1825 (4.1); 4.1541 (2.2); 4.1341 (2.0); 3.0529 (0.7); 3.0425 (1.2); 3.0300 (1.5); 3.0206 (1.6); 3.0079 (1.2); 2.9981 (0.7); 2.5269 (0.5); 2.4938 (11.8); 2.4865 (6.5); 2.3832 (0.6); 2.2984 (16.0); 2.1558 (0.4); 2.1382 (0.9); 2.1278 (1.0); 2.1103 (1.9); 2.0930 (1.1); 2.0832 (2.1); 2.0645 (0.5); 1.5843 (12.6); 1.3447 (0.5); 1.3214 (1.2); 1.3061 (3.3); 1.2981 (3.2); 1.2742 (0.5); 1.0715 (1.3); 1.0563 (3.6); 1.0494 (3.9); 1.0435 (2.0); 1.0348 (2.2); 1.0276 (3.8); 1.0210 (3.5); 1.0066 (1.8); 0.9427 (1.3); 0.9209 (4.0); 0.8971 (2.2); 0.8784 (2.9); 0.8721 (3.9); 0.8551 (4.0); 0.8490 (3.3); 0.8316 (1.4); 0.8148 (2.0); 0.7999 (4.4); 0.7936 (4.2); 0.7827 (4.0); 0.7772 (4.7); 0.7608 (1.5); 0.7008 (1.5); 0.6846 (3.5); 0.6769 (4.1); 0.6720 (3.4); 0.6652 (2.9); 0.6484 (0.9); 0.0496 (1.2); 0.0388 (37.6); 0.0279 (1.3)
I-646:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.4411 (2.4); 9.4220 (2.4); 8.3163 (0.4); 8.2405 (16.0); 7.7450 (5.3); 7.7227 (2.5); 7.6102 (1.1); 7.5907 (4.0); 7.5832 (3.5); 7.5648 (2.7); 7.5457 (0.9); 7.4821 (0.5); 7.4769 (0.6); 7.4617 (1.1); 7.4567 (1.3); 7.4481 (0.8); 7.4428 (1.0); 7.4389 (1.7); 7.4312 (1.0); 7.4181 (0.8); 7.4134 (0.7); 7.3670 (0.6); 7.3628 (0.6); 7.3460 (1.3); 7.3421 (1.4); 7.3293 (1.6); 7.3249 (1.2); 7.3186 (1.8); 7.3166 (1.8); 7.3114 (4.0); 7.3038 (1.3); 7.2996 (1.9); 7.2792 (0.7); 5.2553 (0.4); 5.2380 (1.5); 5.2201 (2.3); 5.2020 (1.5); 5.1844 (0.4); 3.9031 (1.4); 3.7055 (0.7); 3.3325 (304.4); 3.1751 (0.4); 3.1621 (0.4); 2.6761 (1.1); 2.6715 (1.6); 2.6670 (1.1); 2.6625 (0.6); 2.5370 (1.4); 2.5249 (5.4); 2.5201 (8.6); 2.5115 (103.6); 2.5071 (206.4); 2.5026 (266.6); 2.4980 (191.0); 2.4935 (92.7); 2.4585 (0.7); 2.3383 (0.6); 2.3339 (1.1); 2.3293 (1.6); 2.3249 (1.1); 2.3204 (0.6); 1.4913 (10.9); 1.4737 (10.9); 1.4433 (0.4); 1.2345 (0.4); -0.0002 (1.1)
I-647:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2196 (16.0); 7.6557 (3.0); 7.6166 (2.2); 7.6008 (8.6); 7.5962 (7.3); 7.5796 (5.9); 7.5637 (2.3); 7.5572 (2.1); 7.5385 (0.4); 7.4888 (1.4); 7.4270 (1.0); 7.4125 (2.3); 7.3956 (2.7); 7.3544 (12.2); 7.3382 (13.0); 7.2787 (3.4); 7.2648 (4.1); 7.2599 (14.6); 7.1768 (10.4); 7.1719 (14.1); 7.1549 (10.0); 7.0193 (4.2); 7.0040 (4.7); 3.8334 (1.0); 3.8237 (1.4); 3.8136 (2.0); 3.8026 (2.2); 3.7933 (2.3); 3.7823 (2.0); 3.7735 (1.5); 3.7625 (1.0); 3.4187 (0.4); 3.4070 (0.6); 3.4008 (0.5); 3.3974 (0.5); 3.3911 (0.6); 3.3796 (0.4); 2.0673 (1.9); 2.0496 (3.3); 2.0410 (0.6); 2.0308 (2.4); 2.0253 (2.1); 2.0074 (3.2); 1.9888 (2.0); 1.8102 (0.3); 1.7928 (0.7); 1.7835 (0.4); 1.7752 (0.4); 1.7661 (0.7); 1.7486 (0.4); 1.6682 (0.4); 1.6558 (0.5); 1.6511 (0.4); 1.6387 (0.4); 1.6237 (0.5); 1.6112 (0.6); 1.6023 (2.2); 1.5904 (2.7); 1.5849 (2.9); 1.5817 (2.8); 1.5729 (3.1); 1.5698 (3.3); 1.5640 (3.5); 1.5542 (6.0); 1.2567 (0.9); -0.0002 (14.0)
I-648:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5170 (0.6); 7.4972 (2.9); 7.4816 (7.6); 7.3747 (4.0); 7.3453 (0.4); 7.3326 (1.5); 7.3258 (2.4); 7.3202 (2.0); 7.3106 (5.0); 7.2908 (3.7); 7.2579 (5.3); 7.0037 (4.3); 6.9282 (1.5); 6.8941 (2.5); 6.8741 (2.2); 6.7800 (0.6); 5.2932 (0.8); 4.1812 (1.6); 4.1663 (1.6); 4.1444 (3.4); 4.1295 (3.2); 4.1076 (1.8); 4.0927 (1.6); 2.9623 (0.7); 2.9546 (1.2); 2.9457 (1.6); 2.9384 (1.6); 2.9295 (1.2); 2.9217 (0.8); 2.4433 (11.8); 2.2609 (16.0); 1.5835 (0.9); 1.2573 (1.5); 0.8449 (1.0); 0.8274 (4.0); 0.8136 (4.1); 0.7969 (1.2); 0.6624 (1.3); 0.6494 (3.8); 0.6447 (4.3); 0.6232 (1.0); -0.0002 (4.2)
I-649:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7591 (2.1); 8.7418 (2.2); 7.6174 (0.3); 7.5915 (1.4); 7.5686 (4.7); 7.5460 (0.5); 7.5160 (2.4); 7.4851 (1.1); 7.4770 (1.8); 7.4636 (3.4); 7.4451 (3.1); 7.4079 (2.0); 7.3813 (2.3); 7.2988 (5.0); 7.0950 (2.4); 7.0100 (1.3); 6.9837 (1.1); 6.8151 (0.5); 6.7950 (1.0); 6.7751 (0.5); 4.3245 (0.8); 4.3041 (0.8); 4.2755 (1.6); 4.2550 (1.6); 4.2263 (0.8); 4.2059 (0.8); 2.5381 (7.0); 2.3447 (16.0); 2.3277 (9.8); 2.0724 (0.4); 1.2915 (0.6); 0.1092 (0.4); 0.0355 (4.9)
I-650:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2640 (1.2); 7.5680 (0.5); 7.5414 (1.9); 7.5199 (5.3); 7.4984 (0.6); 7.4368 (1.4); 7.4187 (0.9); 7.4046 (0.7); 7.3815 (3.1); 7.3627 (1.3); 7.3540 (2.0); 7.3444 (3.3); 7.3328 (1.5); 7.3177 (3.1); 7.2986 (17.8); 7.0786 (0.6); 7.0374 (2.9); 6.9255 (1.6); 6.8985 (1.4); 5.3373 (1.8); 4.2375 (1.3); 4.2177 (1.2); 4.1892 (2.8); 4.1695 (2.6); 4.1411 (1.5); 4.1213 (1.4); 4.0826 (0.4); 4.0619 (0.3); 3.1686 (0.5); 3.1581 (0.9); 3.1463 (1.2); 3.1359 (1.2); 3.1235 (0.9); 3.1133 (0.6); 2.5125 (1.3); 2.4871 (8.4); 2.3856 (0.4); 2.3589 (2.4); 2.3416 (1.7); 2.3242 (1.2); 2.3139 (1.6); 2.2965 (11.7); 1.6037 (16.0); 1.3743 (0.4); 1.2933 (5.3); 1.2226 (1.1); 1.2077 (2.7); 1.2000 (3.0); 1.1909 (2.9); 1.1832 (2.9); 1.1707 (1.3); 1.1371 (0.4); 1.0314 (1.2); 1.0189 (2.7); 1.0108 (2.5); 1.0044 (1.7); 0.9917 (2.7); 0.9835 (2.4); 0.9691 (0.9); 0.9261 (1.1); 0.9180 (1.0); 0.9026 (3.1); 0.8856 (3.3); 0.8797 (2.7); 0.8628 (1.4); 0.7472 (1.1); 0.7314 (2.6); 0.7233 (3.0); 0.6950 (0.7); 0.1077 (12.0); 0.0957 (0.6); 0.0486 (0.8); 0.0378 (15.9)
I-651:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1059 (1.1); 9.0913 (2.4); 9.0766 (1.4); 8.8564 (7.6); 8.7185 (4.0); 8.7062 (4.4); 8.2616 (0.4); 8.2324 (8.4); 8.0850 (0.7); 7.9604 (2.8); 7.8019 (0.8); 7.7799 (4.7); 7.7627 (3.1); 7.7497 (5.9); 7.7309 (4.9); 7.7187 (5.3); 7.6863 (2.6); 7.6659 (1.8); 7.6278 (0.3); 7.6233 (0.4); 7.5185 (0.9); 7.4973 (6.6); 7.4685 (0.9); 6.0878 (0.7); 6.0757 (1.4); 6.0630 (0.8); 5.9730 (0.7); 5.9606 (1.4); 5.9479 (0.8); 3.9439 (0.9); 3.9343 (1.8); 3.9195 (1.2); 3.8879 (1.1); 3.8777 (1.9); 3.8638 (1.2); 3.3289 (188.0); 2.8985 (16.0); 2.7393 (14.9); 2.5095 (19.4)
I-652:1 H-NMR(400.1 MHz, CDCl3): δ= 8.4147 (3.5); 8.4104 (3.5); 8.3322 (3.5); 8.3258 (3.5); 8.2381 (8.5); 8.0144 (2.1); 7.9179 (0.6); 7.9038 (1.0); 7.8893 (0.6); 7.6403 (3.3); 7.4674 (1.4); 7.4462 (5.0); 7.4330 (3.0); 7.4291 (2.8); 7.4118 (0.8); 7.4080 (0.8); 7.2604 (18.0); 7.2191 (2.0); 7.2137 (3.2); 7.2083 (2.0); 4.4312 (1.3); 4.4158 (1.2); 4.3948 (2.8); 4.3795 (2.7); 4.3584 (1.4); 4.3431 (1.3); 2.9535 (16.0); 2.8807 (14.5); 2.0227 (0.4); 2.0099 (0.8); 2.0014 (0.8); 1.9888 (1.6); 1.9764 (0.9); 1.9679 (0.8); 1.9551 (0.4); 1.5675 (17.1); 1.1338 (1.0); 1.1213 (2.6); 1.1173 (2.7); 1.1050 (1.4); 1.1003 (2.7); 1.0962 (2.5); 1.0842 (1.1); 0.8125 (1.1); 0.8002 (3.5); 0.7966 (2.9); 0.7878 (2.7); 0.7839 (3.5); 0.7713 (1.0); -0.0002 (0.8)
I-653:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9078 (5.0); 7.8091 (0.4); 7.7895 (0.8); 7.7696 (0.4); 7.5635 (1.1); 7.5376 (2.9); 7.5311 (1.6); 7.5106 (0.5); 7.4917 (1.8); 7.4634 (0.8); 7.4565 (1.3); 7.4494 (0.6); 7.4384 (0.5); 7.4325 (0.8); 7.4227 (1.8); 7.3957 (1.8); 7.2987 (2.3); 7.0882 (1.8); 7.0367 (1.0); 7.0100 (0.9); 4.2656 (0.8); 4.2453 (0.8); 4.2156 (1.8); 4.1954 (1.7); 4.1657 (0.9); 4.1454 (0.9); 3.7418 (1.6); 3.7230 (2.9); 3.7038 (1.8); 3.3685 (16.0); 2.9800 (1.7); 2.9609 (2.8); 2.9421 (1.5); 2.5348 (5.5); 2.5280 (3.1); 2.3226 (7.3); 1.6930 (2.1); 0.0363 (2.0)
I-654:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2398 (2.0); 9.2242 (4.4); 9.2085 (2.3); 8.8513 (13.7); 8.7126 (7.4); 8.7003 (7.8); 8.1504 (16.0); 8.0292 (1.3); 7.9601 (1.7); 7.8018 (1.4); 7.7820 (4.4); 7.7629 (10.9); 7.7443 (6.4); 7.7246 (10.0); 7.7137 (9.0); 7.7011 (7.8); 7.6485 (4.0); 7.6288 (3.6); 7.6081 (0.6); 7.5933 (6.1); 7.5719 (7.3); 7.5564 (1.2); 7.2631 (3.8); 7.2589 (4.0); 7.2422 (3.7); 7.2376 (3.7); 4.3440 (1.8); 4.3281 (2.0); 4.3098 (4.2); 4.2938 (4.2); 4.2757 (2.6); 4.2599 (2.4); 3.3357 (281.8); 2.8982 (9.7); 2.7388 (9.0); 2.5098 (32.2); 2.5059 (25.6); 1.2427 (0.5)
I-655:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.3667 (0.8); 9.3542 (1.7); 9.3417 (0.8); 7.3396 (2.2); 7.3236 (2.5); 7.1746 (0.8); 7.1587 (2.0); 7.1428 (1.4); 7.0988 (2.6); 7.0909 (1.1); 7.0770 (1.4); 7.0627 (0.7); 7.0599 (0.6); 6.9851 (1.4); 6.9692 (1.2); 6.9423 (0.8); 6.9397 (0.8); 6.9267 (1.4); 6.9133 (0.7); 4.1569 (0.6); 4.1444 (0.7); 4.1270 (1.5); 4.1144 (1.4); 4.0969 (0.8); 4.0844 (0.7); 3.3290 (90.6); 2.5266 (0.5); 2.5229 (0.6); 2.5121 (10.7); 2.5087 (21.8); 2.5051 (29.4); 2.5016 (21.0); 2.4982 (9.8); 2.4413 (7.0); 2.2352 (9.9); 2.2092 (16.0); 2.0762 (7.7); 2.0645 (1.2); 2.0542 (0.7); 2.0477 (0.6); 1.0412 (0.8); 1.0325 (2.2); 1.0282 (2.3); 1.0246 (1.2); 1.0198 (1.2); 1.0156 (2.2); 1.0113 (2.3); 1.0031 (0.8); 0.7944 (0.9); 0.7859 (2.5); 0.7821 (2.6); 0.7758 (2.4); 0.7719 (2.6); 0.7629 (0.8)
I-656:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2417 (1.6); 9.2211 (1.6); 8.0772 (6.9); 7.9605 (2.4); 7.2498 (0.6); 7.2459 (0.6); 7.2287 (1.6); 7.2252 (1.5); 7.2077 (1.2); 7.2045 (1.2); 7.1703 (1.1); 7.1522 (1.5); 7.1333 (0.7); 6.9854 (0.9); 6.9823 (0.9); 6.9655 (1.6); 6.9483 (0.9); 6.4946 (3.4); 5.1687 (0.4); 5.1530 (0.8); 5.1353 (0.8); 3.9016 (16.0); 3.3300 (18.3); 2.8981 (14.2); 2.7388 (12.9); 2.5132 (9.6); 2.5091 (12.2); 2.5049 (9.6); 2.4773 (1.0); 2.4502 (0.4); 2.3473 (11.4); 2.0369 (0.4); 2.0201 (0.7); 1.9984 (0.6); 1.9867 (0.4); 1.9066 (0.4); 1.8915 (0.5); 1.8735 (0.6); 1.8567 (0.8); 1.8380 (0.8); 1.8221 (0.6); 1.8165 (0.6); 1.8059 (0.6); 1.7892 (0.6); 1.7672 (0.6); 1.7505 (0.6); 1.7296 (0.5); 1.7140 (0.4)
I-657:1 H-NMR(499.9 MHz, CDCl3): δ= 7.6252 (3.2); 7.5474 (0.4); 7.5314 (2.2); 7.5193 (5.7); 7.4917 (0.3); 7.4362 (2.6); 7.4189 (4.0); 7.4123 (3.2); 7.3496 (0.4); 7.3394 (1.0); 7.3341 (1.6); 7.3295 (1.4); 7.3219 (1.3); 7.3056 (2.1); 7.3034 (2.0); 7.2887 (1.6); 7.2862 (1.6); 7.2627 (2.4); 6.7147 (0.8); 6.7022 (1.6); 6.6897 (0.9); 4.3819 (1.0); 4.3692 (1.0); 4.3529 (2.3); 4.3402 (2.2); 4.3240 (1.3); 4.3112 (1.2); 4.0975 (0.6); 4.0832 (0.6); 3.2306 (0.3); 3.2164 (0.8); 3.2022 (1.2); 3.1881 (0.9); 3.1741 (0.4); 2.0238 (2.5); 1.6454 (1.7); 1.3780 (15.7); 1.3638 (16.0); 1.3328 (0.9); 1.3181 (1.8); 1.2611 (1.0); 1.2470 (1.5); 1.2327 (0.8); 1.1139 (0.8); 1.1008 (0.8); 0.8710 (0.4); 0.8563 (0.5); 0.8428 (0.3); -0.0002 (1.9)
I-658:1 H-NMR(400.1 MHz, CDCl3): δ= 8.4121 (4.2); 8.4088 (4.2); 8.3287 (3.8); 8.3227 (3.8); 8.2493 (11.2); 8.0136 (2.2); 7.9269 (1.5); 7.9127 (0.9); 7.4777 (4.6); 7.4562 (8.3); 7.4060 (7.9); 7.3847 (4.3); 7.2605 (19.3); 7.2109 (2.9); 7.2055 (4.7); 7.2003 (2.9); 4.2129 (1.9); 4.1978 (1.9); 4.1771 (4.2); 4.1620 (4.0); 4.1412 (2.1); 4.1261 (2.0); 2.9532 (16.0); 2.8803 (14.9); 2.0196 (0.5); 2.0068 (1.1); 1.9983 (1.2); 1.9859 (2.2); 1.9732 (1.3); 1.9648 (1.2); 1.9521 (0.6); 1.5738 (18.8); 1.1318 (1.3); 1.1193 (3.7); 1.1151 (3.9); 1.1028 (2.1); 1.0983 (3.8); 1.0941 (3.6); 1.0821 (1.5); 0.8078 (1.6); 0.7955 (5.0); 0.7919 (4.2); 0.7831 (3.9); 0.7791 (5.0); 0.7666 (1.3); -0.0002 (0.9)
I-659:1 H-NMR(300.2 MHz, CDCl3): δ= 8.6837 (3.3); 8.6641 (3.3); 7.6160 (0.4); 7.5899 (1.8); 7.5751 (4.2); 7.5681 (5.3); 7.5469 (3.3); 7.5141 (2.5); 7.5081 (2.7); 7.4880 (2.5); 7.4610 (0.4); 7.4556 (0.4); 7.4426 (1.1); 7.4340 (1.8); 7.4214 (4.9); 7.4163 (3.5); 7.4063 (3.4); 7.4015 (4.4); 7.2985 (2.5); 7.2753 (1.3); 7.2546 (0.7); 7.2289 (1.6); 7.2224 (1.6); 7.2008 (1.4); 7.1942 (1.3); 5.3240 (1.5); 4.4815 (0.9); 4.4603 (0.9); 4.4326 (1.8); 4.4114 (1.8); 4.3836 (0.9); 4.3624 (0.9); 2.3303 (16.0); 2.3132 (0.6); 2.2927 (0.4); 2.0549 (0.5); 1.2870 (0.7); 0.0280 (1.7)
I-660:1 H-NMR(300.2 MHz, CDCl3): δ= 9.7825 (1.4); 8.6910 (3.1); 8.6142 (1.7); 8.5991 (1.8); 8.1345 (0.8); 8.1174 (1.4); 7.6508 (0.7); 7.6445 (0.8); 7.6259 (2.6); 7.6066 (6.4); 7.6038 (6.3); 7.5861 (1.1); 7.5461 (2.8); 7.5294 (2.9); 7.5035 (6.0); 7.4760 (6.7); 7.4390 (1.8); 7.4289 (2.5); 7.4213 (2.2); 7.4030 (6.8); 7.3743 (3.6); 7.2987 (74.3); 7.2321 (0.4); 6.9477 (0.5); 5.3383 (0.4); 4.2724 (0.3); 4.2445 (0.8); 4.2221 (0.8); 4.1951 (0.9); 4.1794 (1.3); 4.1619 (0.7); 4.1502 (0.7); 4.1304 (1.4); 4.1129 (1.1); 4.0865 (0.9); 4.0676 (0.9); 2.1299 (0.8); 2.1162 (1.3); 2.1069 (1.3); 2.0932 (1.0); 1.7402 (0.7); 1.6403 (4.6); 1.4857 (0.7); 1.4603 (1.0); 1.4281 (0.6); 1.3738 (1.3); 1.2923 (16.0); 1.1437 (0.9); 1.0619 (0.5); 1.0379 (0.7); 1.0144 (0.6); 0.9744 (0.5); 0.9173 (2.6); 0.8916 (2.6); 0.8634 (1.8); 0.7753 (0.5); 0.7512 (0.5); 0.7258 (0.3); 0.6775 (0.4); 0.6534 (0.6); 0.6427 (0.8); 0.6234 (1.2); 0.6112 (0.8); 0.5884 (0.7); 0.5597 (0.9); 0.5481 (0.7); 0.5395 (0.9); 0.5266 (1.2); 0.5077 (0.9); 0.4849 (0.4); 0.4168 (0.5); 0.3975 (0.8); 0.3818 (1.0); 0.3632 (1.0); 0.3316 (0.4); 0.2324 (0.3); 0.1720 (0.4); 0.1502 (0.9); 0.1317 (0.9); 0.1183 (0.9); 0.1069 (2.1); 0.0479 (2.5); 0.0371 (73.0); 0.0263 (4.0); -0.0292 (0.5); -0.1624 (0.4)
I-661:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2387 (1.8); 9.2234 (4.0); 9.2076 (2.1); 9.1876 (0.4); 8.8512 (12.8); 8.8301 (0.6); 8.7130 (7.0); 8.7007 (7.6); 8.1442 (16.0); 8.0961 (0.3); 8.0260 (1.4); 7.9603 (2.3); 7.8738 (6.8); 7.8045 (1.3); 7.7842 (4.0); 7.7640 (4.1); 7.7443 (5.6); 7.7312 (8.0); 7.7137 (7.6); 7.7013 (7.2); 7.6756 (0.5); 7.6488 (3.9); 7.6291 (2.9); 7.5693 (0.4); 7.5513 (0.4); 7.5186 (4.9); 7.4974 (7.1); 7.4817 (0.9); 7.4039 (4.0); 7.3997 (4.1); 7.3831 (3.3); 7.3788 (3.1); 4.3378 (1.6); 4.3219 (1.8); 4.3037 (3.7); 4.2878 (3.7); 4.2694 (2.3); 4.2537 (2.2); 4.2206 (0.3); 3.3333 (291.9); 2.8982 (13.9); 2.7389 (12.6); 2.5137 (23.5); 2.5095 (32.0); 2.5054 (24.6); 1.2420 (0.5)
I-662:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 11.2331 (0.7); 9.1405 (0.5); 9.1287 (0.7); 9.1215 (1.1); 9.1062 (2.4); 9.0899 (1.2); 8.3096 (6.2); 7.8264 (9.8); 7.7869 (0.6); 7.7752 (0.6); 7.7501 (1.1); 7.7302 (3.1); 7.7103 (2.8); 7.6855 (3.6); 7.6656 (2.0); 7.6430 (4.2); 7.6071 (0.4); 7.5776 (2.5); 7.5580 (1.8); 7.4401 (0.3); 7.3447 (0.6); 7.3249 (0.8); 7.3151 (3.6); 7.2950 (3.8); 7.1119 (1.2); 7.0919 (0.8); 7.0698 (4.6); 6.9190 (2.2); 6.9010 (2.0); 6.6428 (0.9); 6.4329 (0.5); 5.2202 (0.3); 4.2690 (0.4); 4.2136 (0.4); 4.2008 (0.5); 4.1936 (0.5); 4.1818 (0.4); 4.1319 (1.4); 4.1165 (1.5); 4.0947 (2.9); 4.0791 (2.8); 4.0574 (1.8); 4.0408 (1.5); 4.0150 (0.6); 3.9789 (0.4); 3.9435 (0.6); 3.9173 (0.7); 3.8990 (0.5); 3.8712 (0.4); 3.8655 (0.5); 3.8450 (0.5); 3.8321 (0.5); 3.8068 (0.4); 3.7953 (0.4); 3.7826 (0.4); 3.7592 (0.5); 3.7414 (0.5); 3.7150 (0.6); 3.6886 (0.8); 3.6750 (0.8); 3.6624 (0.7); 3.6528 (0.7); 3.6354 (0.5); 3.6216 (0.5); 3.5732 (0.6); 3.5661 (0.6); 3.4995 (0.9); 3.4760 (1.0); 3.4545 (1.4); 3.3353 (2896.4); 3.2640 (3.2); 3.2463 (6.7); 3.2288 (3.5); 3.0005 (4.0); 2.9831 (7.7); 2.9650 (3.3); 2.8756 (0.5); 2.8314 (0.8); 2.8083 (0.4); 2.7001 (0.8); 2.6808 (3.1); 2.6767 (4.9); 2.6721 (6.8); 2.6676 (5.2); 2.6466 (0.9); 2.6142 (1.1); 2.5930 (1.5); 2.5810 (1.4); 2.5424 (6.4); 2.5255 (16.8); 2.5205 (25.6); 2.5120 (353.2); 2.5077 (716.4); 2.5032 (941.3); 2.4987 (678.9); 2.4944 (328.6); 2.4185 (11.8); 2.3817 (2.4); 2.3606 (0.8); 2.3345 (4.0); 2.3299 (5.5); 2.3256 (4.1); 2.3039 (2.6); 2.2921 (1.3); 2.2202 (16.0); 2.1921 (0.8); 2.0723 (7.5); 1.9638 (0.4); 1.9449 (0.5); 1.4016 (0.5); 1.3787 (0.4); 1.3431 (0.4); 1.2344 (5.3); 0.8549 (0.6); 0.8126 (0.5); 0.7906 (0.4); 0.7717 (0.4); 0.7607 (0.5); 0.7397 (0.6); 0.7208 (0.5); 0.2184 (6.0); 0.2103 (7.8); 0.1595 (0.4); 0.1391 (0.8); 0.1204 (4.8); 0.1169 (4.2); 0.1102 (3.7); 0.0993 (22.8); 0.0931 (9.3); 0.0698 (7.2); 0.0335 (0.4); 0.0080 (1.8); -0.0001 (55.5); -0.0084 (1.8); -0.0230 (2.2); -0.0835 (0.4)
I-663:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0033 (1.4); 7.4926 (0.9); 7.4894 (0.9); 7.4733 (1.6); 7.4571 (1.0); 7.3484 (2.4); 7.3283 (2.6); 7.2600 (15.5); 7.2422 (1.8); 7.2247 (1.1); 7.1152 (1.2); 7.0947 (1.9); 7.0740 (0.9); 7.0538 (3.3); 6.9417 (1.8); 6.9217 (1.6); 6.3956 (0.7); 6.3797 (1.1); 6.3664 (0.6); 6.0433 (0.6); 6.0350 (0.7); 6.0265 (0.7); 6.0180 (0.6); 5.9274 (0.6); 5.9190 (0.7); 5.9105 (0.7); 5.9023 (0.6); 4.2138 (0.3); 4.2048 (0.3); 4.1967 (0.4); 4.1891 (0.3); 4.1768 (0.4); 4.1685 (0.4); 4.1607 (0.4); 4.1506 (0.6); 4.1333 (0.3); 4.1245 (0.3); 4.1130 (0.4); 4.1046 (0.4); 4.0967 (0.4); 4.0878 (0.4); 3.9286 (0.4); 3.9141 (0.5); 3.8971 (0.4); 3.8752 (0.7); 3.8601 (0.8); 3.8429 (0.4); 3.8384 (0.4); 3.8225 (0.4); 2.9517 (9.1); 2.8757 (8.6); 2.4081 (16.0); 1.8676 (0.3); 1.8548 (0.7); 1.8463 (0.8); 1.8342 (1.3); 1.8216 (0.8); 1.8139 (0.7); 1.8008 (0.4); 1.5588 (15.8); 1.0195 (0.9); 1.0074 (2.4); 1.0028 (2.5); 0.9865 (2.4); 0.9822 (2.2); 0.9707 (0.8); 0.6884 (1.0); 0.6764 (3.1); 0.6642 (2.6); 0.6602 (2.9); 0.6479 (0.8); -0.0002 (14.9)
I-664:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2259 (0.4); 7.3480 (0.3); 7.3342 (3.4); 7.3182 (3.6); 7.2621 (5.1); 7.1000 (1.1); 7.0840 (2.9); 7.0679 (2.9); 7.0580 (2.0); 7.0541 (2.2); 7.0438 (2.2); 7.0411 (2.5); 7.0253 (5.4); 6.9182 (2.4); 6.9026 (2.1); 6.8390 (1.6); 6.8351 (1.9); 6.8244 (3.3); 6.8105 (2.4); 6.8073 (2.1); 5.2965 (2.4); 4.2133 (1.8); 4.2064 (1.0); 4.2010 (1.8); 4.1940 (1.0); 4.1850 (3.7); 4.1726 (3.5); 4.1566 (1.9); 4.1443 (1.7); 3.0293 (5.8); 3.0144 (13.2); 3.0053 (4.2); 2.9995 (5.6); 2.9379 (1.6); 2.4744 (12.3); 2.3439 (0.4); 2.2899 (0.6); 2.2635 (16.0); 2.2420 (0.9); 2.2301 (6.2); 2.2215 (6.9); 2.2151 (14.5); 2.2087 (5.9); 2.2001 (5.1); 2.1906 (0.6); 2.1010 (0.6); 2.0907 (1.2); 2.0840 (1.3); 2.0739 (2.0); 2.0636 (1.3); 2.0570 (1.2); 2.0466 (0.6); 1.6143 (1.2); 1.2554 (0.5); 1.0491 (0.4); 1.0390 (1.6); 1.0298 (4.0); 1.0260 (3.9); 1.0168 (2.7); 1.0128 (4.2); 1.0090 (3.8); 1.0000 (1.7); 0.9871 (0.3); 0.7927 (0.3); 0.7895 (0.4); 0.7791 (2.0); 0.7697 (4.9); 0.7666 (4.6); 0.7597 (4.3); 0.7564 (4.6); 0.7466 (1.6); -0.0002 (7.1)
I-665:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1021 (1.5); 9.0871 (3.0); 9.0728 (1.6); 8.0478 (12.4); 7.9609 (2.5); 7.6516 (4.8); 7.5684 (4.5); 7.5474 (5.6); 7.5180 (1.6); 7.4989 (3.0); 7.4782 (1.9); 7.3699 (3.2); 7.3649 (3.2); 7.3490 (2.8); 7.3439 (2.7); 7.1892 (13.2); 7.1716 (4.0); 7.1662 (4.8); 6.0607 (0.9); 6.0475 (1.7); 6.0358 (1.0); 5.9453 (0.9); 5.9325 (1.8); 5.9204 (1.0); 3.8949 (1.5); 3.8801 (2.4); 3.8711 (1.4); 3.8645 (1.2); 3.8372 (1.9); 3.8227 (2.8); 3.8115 (1.4); 3.3363 (157.4); 2.8986 (16.0); 2.7392 (14.2); 2.5143 (14.3); 2.5101 (19.8); 2.5059 (15.5); 1.5680 (0.9); 1.5522 (3.3); 1.5481 (3.5); 1.5331 (1.4); 1.5196 (1.2); 1.5035 (3.4); 1.4993 (3.6); 1.4848 (1.5); 1.2302 (1.1); 1.2141 (3.5); 1.2090 (4.2); 1.1913 (4.3); 1.1868 (3.8); 1.1706 (1.2)
I-666:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.8152 (1.0); 8.8015 (2.0); 8.7873 (1.1); 8.0559 (6.8); 7.9609 (0.8); 7.4756 (1.3); 7.4561 (2.9); 7.4367 (1.8); 7.2362 (2.3); 7.2170 (2.0); 7.1762 (5.3); 7.1547 (1.9); 7.0533 (2.5); 7.0342 (3.0); 6.9408 (3.7); 6.8231 (2.0); 6.8044 (1.8); 3.4757 (1.1); 3.4588 (2.6); 3.4412 (2.8); 3.4249 (1.4); 3.3376 (80.4); 3.1251 (0.6); 3.1030 (0.8); 3.0941 (1.1); 3.0694 (1.1); 3.0418 (0.7); 2.8989 (4.6); 2.8083 (2.2); 2.7896 (3.8); 2.7718 (2.2); 2.7396 (4.3); 2.5107 (11.6); 2.2661 (16.0); 2.1918 (14.6); 2.0509 (0.6); 2.0353 (0.7); 2.0211 (1.5); 2.0056 (1.8); 1.9938 (1.9); 1.9849 (1.1); 1.9747 (1.3); 1.9629 (0.9)
I-667:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9973 (1.5); 7.4968 (0.8); 7.4937 (0.9); 7.4774 (1.6); 7.4646 (2.7); 7.4449 (2.5); 7.2738 (3.0); 7.2601 (12.8); 7.2342 (0.8); 7.2309 (0.8); 7.2139 (1.6); 7.1967 (1.0); 7.1166 (1.1); 7.1135 (1.0); 7.0962 (1.7); 7.0930 (1.6); 7.0759 (0.7); 7.0726 (0.7); 6.9885 (1.5); 6.9684 (1.4); 6.3962 (0.6); 6.3818 (1.0); 6.3667 (0.6); 4.4413 (1.0); 4.4253 (1.1); 4.4058 (2.2); 4.3898 (2.1); 4.3701 (1.1); 4.3542 (1.0); 2.9504 (10.0); 2.8725 (9.4); 2.3798 (16.0); 2.3077 (10.3); 2.2031 (0.4); 1.5610 (13.6); -0.0002 (13.1)
I-668:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9959 (0.6); 7.4978 (0.8); 7.4945 (0.8); 7.4783 (1.5); 7.4743 (1.0); 7.4625 (0.9); 7.4589 (0.9); 7.4033 (2.5); 7.3344 (1.6); 7.3133 (3.0); 7.2687 (2.1); 7.2596 (17.5); 7.2319 (0.7); 7.2286 (0.8); 7.2115 (1.6); 7.1944 (1.0); 7.1910 (0.9); 7.1211 (1.1); 7.1177 (1.0); 7.1007 (1.7); 7.0973 (1.6); 7.0801 (0.7); 7.0771 (0.7); 6.4306 (0.6); 6.4164 (1.0); 6.4020 (0.6); 4.2430 (1.0); 4.2269 (1.0); 4.2071 (2.1); 4.1911 (2.0); 4.1712 (1.1); 4.1552 (1.0); 2.9507 (4.5); 2.8721 (4.2); 2.5255 (7.3); 2.3610 (16.0); 1.5520 (19.1); -0.0002 (17.6)
I-669:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0112 (0.7); 7.4912 (0.9); 7.4752 (1.5); 7.4593 (0.9); 7.4561 (0.8); 7.3617 (2.1); 7.3420 (2.4); 7.2594 (34.3); 7.2433 (1.9); 7.2261 (1.0); 7.2227 (1.0); 7.1875 (2.7); 7.1180 (1.0); 7.1148 (1.0); 7.0978 (1.7); 7.0943 (1.7); 7.0773 (0.8); 7.0455 (1.6); 7.0242 (1.4); 6.3381 (0.9); 6.0595 (0.5); 6.0523 (0.6); 6.0443 (0.6); 6.0349 (0.5); 5.9432 (0.5); 5.9349 (0.6); 5.9278 (0.6); 5.9187 (0.6); 4.2146 (0.3); 4.1873 (0.4); 4.1778 (0.4); 4.1702 (0.4); 4.1609 (0.6); 4.1514 (0.3); 4.1438 (0.3); 4.1231 (0.4); 4.1148 (0.4); 4.1068 (0.4); 4.0978 (0.4); 3.9480 (0.4); 3.9326 (0.5); 3.9155 (0.4); 3.8931 (0.7); 3.8782 (0.7); 3.8614 (0.4); 3.8407 (0.4); 2.9532 (5.2); 2.8796 (4.8); 2.4186 (16.0); 2.3015 (11.2); 1.5477 (27.7); -0.0002 (34.2)
I-670:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9957 (1.5); 7.4823 (1.0); 7.4643 (1.7); 7.4467 (1.1); 7.2795 (2.5); 7.2597 (12.0); 7.2496 (2.2); 7.2299 (1.2); 7.1062 (1.3); 7.0860 (2.1); 7.0654 (1.0); 7.0160 (1.9); 6.9945 (2.0); 6.9848 (3.3); 6.5205 (0.7); 6.5072 (1.1); 6.4926 (0.7); 5.9250 (0.6); 5.9176 (0.7); 5.9049 (0.7); 5.8971 (0.7); 5.8057 (0.6); 5.7987 (0.7); 5.7864 (0.7); 5.7785 (0.6); 4.1548 (0.3); 4.1474 (0.4); 4.1366 (0.4); 4.1297 (0.4); 4.1181 (0.4); 4.1105 (0.4); 4.1009 (0.4); 4.0932 (0.4); 4.0828 (0.4); 4.0747 (0.4); 4.0645 (0.3); 4.0568 (0.4); 4.0453 (0.4); 4.0375 (0.4); 4.0278 (0.4); 4.0202 (0.4); 3.7602 (0.4); 3.7471 (0.4); 3.7399 (0.4); 3.7252 (0.6); 3.7138 (0.5); 3.7025 (0.7); 3.6918 (0.5); 3.6807 (0.6); 3.6650 (0.3); 3.6583 (0.3); 2.9490 (8.7); 2.8712 (8.5); 2.4374 (16.0); 2.3636 (13.7); 2.2923 (12.4); 1.5659 (10.8); -0.0002 (9.3); -0.0015 (9.2)
I-671:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9822 (1.6); 7.5465 (3.2); 7.4992 (0.9); 7.4961 (0.9); 7.4798 (1.5); 7.4638 (1.0); 7.4605 (0.9); 7.3538 (7.7); 7.2609 (7.8); 7.2365 (1.7); 7.2194 (1.0); 7.2163 (1.0); 7.1243 (1.1); 7.1211 (1.1); 7.1038 (1.8); 7.1007 (1.7); 7.0833 (0.8); 7.0801 (0.7); 6.5537 (0.6); 6.5398 (1.1); 6.5256 (0.6); 6.0270 (0.6); 6.0189 (0.7); 6.0101 (0.7); 6.0021 (0.6); 5.9109 (0.6); 5.9028 (0.7); 5.8941 (0.7); 5.8860 (0.6); 4.1618 (0.4); 4.1534 (0.4); 4.1453 (0.4); 4.1367 (0.5); 4.1182 (0.3); 4.0973 (0.4); 4.0894 (0.4); 4.0813 (0.4); 4.0733 (0.4); 3.9544 (0.4); 3.9386 (0.6); 3.9225 (0.4); 3.9179 (0.4); 3.9001 (0.6); 3.8830 (0.7); 3.8663 (0.4); 3.8617 (0.4); 3.8454 (0.4); 2.9480 (10.7); 2.8648 (10.0); 2.4083 (16.0); 1.5783 (8.3); -0.0002 (7.6)
I-672:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2714 (16.0); 8.0546 (1.0); 8.0444 (1.6); 7.5095 (2.3); 7.5016 (1.8); 7.4938 (6.0); 7.4779 (4.5); 7.4692 (0.7); 7.4666 (0.6); 7.4517 (4.6); 7.4360 (2.3); 7.4131 (5.0); 7.3961 (9.4); 7.3899 (4.2); 7.3510 (0.5); 7.3469 (0.4); 7.3342 (0.4); 7.3301 (0.5); 7.3119 (3.2); 7.3081 (5.0); 7.3046 (3.3); 7.2598 (58.0); 7.2068 (3.5); 7.2027 (3.4); 7.1900 (3.0); 7.1860 (2.9); 7.1775 (2.3); 7.1756 (2.5); 7.1730 (2.4); 7.1711 (2.2); 7.1617 (2.0); 7.1597 (2.2); 7.1571 (2.2); 7.1551 (2.0); 7.1315 (0.6); 7.1280 (0.5); 7.1082 (0.4); 7.1033 (0.6); 7.0919 (0.4); 7.0874 (0.6); 7.0481 (0.3); 6.0652 (1.1); 6.0588 (1.2); 6.0512 (1.2); 6.0448 (1.3); 5.9721 (1.1); 5.9656 (1.3); 5.9581 (1.3); 5.9517 (1.3); 5.6815 (9.6); 5.5137 (3.6); 5.5073 (3.5); 5.2854 (7.6); 5.2837 (7.7); 5.1912 (7.5); 5.1895 (7.7); 4.2745 (0.7); 4.2679 (0.7); 4.2612 (0.7); 4.2546 (0.7); 4.2452 (0.8); 4.2386 (0.8); 4.2319 (0.8); 4.2252 (0.9); 4.2214 (0.9); 4.2148 (0.8); 4.2081 (0.8); 4.2015 (0.8); 4.1920 (0.9); 4.1854 (0.8); 4.1787 (0.9); 4.1722 (0.8); 3.8463 (0.7); 3.8359 (0.8); 3.8323 (0.8); 3.8220 (0.8); 3.8170 (0.7); 3.8065 (0.8); 3.8031 (1.5); 3.7928 (1.5); 3.7896 (0.9); 3.7790 (0.8); 3.7740 (0.8); 3.7637 (0.8); 3.7600 (0.7); 3.7497 (0.6); 2.9552 (0.5); 2.8824 (0.4); 1.5463 (5.0); 1.5031 (0.8); 1.5001 (0.8); 1.4882 (0.4); 1.1045 (0.5); 1.1013 (0.6); 1.0868 (0.6); 1.0838 (0.5); 0.0063 (2.5); -0.0002 (68.0); -0.0068 (2.6)
I-673:1 H-NMR(499.9 MHz, CDCl3): δ= 8.1539 (1.6); 7.5772 (1.2); 7.5670 (1.3); 7.4342 (0.7); 7.3779 (0.3); 7.3740 (0.4); 7.3702 (0.4); 7.2596 (8.6); 6.9500 (0.8); 6.8917 (0.6); 6.8886 (0.6); 6.8765 (1.2); 6.8600 (0.4); 5.5303 (1.6); 5.5172 (1.6); 5.2983 (0.5); 2.7317 (5.0); 2.3475 (0.5); 2.2436 (0.4); 2.2310 (4.2); 2.2175 (0.4); 2.1810 (4.2); 1.6361 (0.4); 1.6210 (0.4); 1.6055 (0.4); 1.5607 (1.5); 1.4786 (0.4); 1.4316 (0.8); 1.4222 (0.7); 1.4147 (0.4); 1.3493 (0.4); 1.3360 (0.9); 1.3330 (0.9); 1.2999 (1.4); 1.2924 (1.5); 1.2841 (2.1); 1.2552 (16.0); 1.2224 (2.0); 1.1597 (0.4); 1.1414 (0.3); 1.1334 (0.4); 1.1067 (0.5); 1.0727 (0.4); 0.9951 (0.4); 0.8934 (1.3); 0.8889 (1.1); 0.8802 (2.2); 0.8662 (1.4); 0.8440 (1.7); 0.0695 (6.3); -0.0002 (8.1); -0.0065 (0.4)
I-674:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5095 (0.4); 8.4873 (0.6); 8.4659 (0.4); 8.1937 (0.7); 8.1839 (4.8); 7.6291 (2.4); 7.6118 (4.0); 7.5011 (1.8); 7.4424 (0.4); 7.4295 (0.8); 7.4204 (0.8); 7.4153 (1.2); 7.4091 (1.0); 7.3995 (0.7); 7.3909 (0.5); 7.2985 (4.3); 7.2853 (3.9); 7.2780 (1.3); 7.2628 (1.4); 7.2553 (4.6); 7.2441 (0.5); 7.0108 (0.5); 6.9996 (4.4); 6.9921 (1.4); 6.9769 (1.2); 6.9696 (3.6); 6.9582 (0.4); 5.6420 (0.5); 5.6195 (0.5); 5.5789 (4.7); 5.5565 (4.6); 2.7724 (16.0); 1.6288 (1.2); 1.3272 (0.4); 1.2930 (1.8); 0.9377 (0.4); 0.9183 (1.1); 0.8950 (0.5); 0.1083 (0.4); 0.0366 (3.7)
I-675:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1740 (1.4); 9.1624 (2.8); 9.1504 (1.4); 8.1040 (16.0); 7.7601 (5.2); 7.5561 (1.3); 7.5531 (1.5); 7.5406 (2.9); 7.5373 (2.3); 7.5350 (2.5); 7.5311 (2.2); 7.5283 (2.0); 7.5251 (1.9); 7.5181 (5.0); 7.5145 (5.2); 7.4998 (8.6); 7.4946 (1.8); 7.4828 (4.8); 7.4660 (1.8); 7.4630 (1.5); 7.3519 (2.4); 7.3356 (4.0); 7.3199 (1.8); 6.0458 (1.0); 6.0375 (1.4); 6.0339 (1.2); 6.0256 (1.0); 5.9535 (1.0); 5.9453 (1.4); 5.9416 (1.2); 5.9334 (1.1); 5.7609 (2.4); 4.6368 (9.9); 3.9214 (0.4); 3.9049 (0.8); 3.8925 (1.4); 3.8804 (1.2); 3.8753 (1.4); 3.8720 (1.2); 3.8633 (1.2); 3.8597 (1.1); 3.8540 (0.6); 3.8469 (1.6); 3.8351 (1.6); 3.8272 (1.0); 3.8244 (1.1); 3.8161 (0.8); 3.8065 (0.3); 3.7981 (0.3); 3.7955 (0.4); 3.3205 (35.1); 2.5151 (4.5); 2.5115 (9.7); 2.5079 (13.6); 2.5042 (9.9); 2.5007 (4.7)
I-676:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.0925 (1.4); 9.0809 (2.9); 9.0689 (1.5); 8.0075 (16.0); 7.6863 (6.0); 7.4577 (0.8); 7.4540 (0.7); 7.4494 (1.2); 7.4460 (0.9); 7.4410 (1.7); 7.4373 (1.9); 7.4325 (6.0); 7.4290 (7.8); 7.4264 (10.9); 7.4097 (1.7); 7.2815 (0.7); 7.2759 (0.9); 7.2685 (1.4); 7.2617 (2.3); 7.2502 (2.2); 7.2433 (3.8); 7.2361 (5.7); 7.2257 (4.5); 7.2101 (0.5); 7.1783 (1.4); 7.1671 (1.2); 7.1645 (1.0); 7.1592 (0.6); 6.4529 (0.8); 6.4510 (0.9); 6.4221 (0.8); 6.4097 (0.7); 6.3901 (2.0); 6.3778 (0.4); 6.3667 (1.9); 5.9758 (1.0); 5.9674 (1.5); 5.9622 (1.6); 5.9558 (1.2); 5.9476 (2.5); 5.9387 (0.8); 5.9334 (2.4); 5.9245 (2.2); 5.9192 (0.8); 5.9103 (2.2); 5.8961 (0.7); 5.8837 (1.0); 5.8754 (1.5); 5.8722 (1.4); 5.8636 (1.1); 5.6897 (10.5); 3.8505 (0.4); 3.8339 (0.8); 3.8215 (1.5); 3.8172 (1.2); 3.8145 (1.3); 3.8050 (1.8); 3.7946 (1.1); 3.7883 (1.1); 3.7758 (1.7); 3.7665 (1.3); 3.7591 (1.3); 3.7565 (1.3); 3.7478 (0.9); 3.7384 (0.3); 3.7275 (0.3); 3.2513 (24.2); 2.4443 (2.8); 2.4407 (5.9); 2.4371 (8.2); 2.4334 (5.9); 2.4299 (2.7); 1.8430 (2.0); 1.8417 (2.0); 1.8309 (2.1); 1.7420 (7.4); 1.7276 (7.3)
I-677:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2943 (16.0); 7.9246 (1.0); 7.9076 (1.5); 7.8885 (1.0); 7.5424 (1.5); 7.5368 (1.8); 7.5218 (1.7); 7.5163 (3.4); 7.5109 (2.2); 7.4960 (1.9); 7.4904 (2.1); 7.4712 (4.5); 7.4425 (8.9); 7.4373 (5.5); 7.4313 (4.2); 7.4233 (1.8); 7.4177 (1.6); 7.3993 (1.7); 7.3953 (3.2); 7.3904 (2.3); 7.3723 (2.4); 7.3666 (2.1); 7.2990 (12.1); 7.2879 (3.5); 7.2839 (6.5); 7.2770 (3.8); 7.2611 (3.7); 7.2567 (5.8); 7.2491 (2.9); 7.2348 (1.6); 7.2305 (1.6); 6.1406 (1.1); 6.1300 (1.2); 6.1181 (1.2); 6.1073 (1.2); 5.9858 (1.1); 5.9752 (1.2); 5.9633 (1.2); 5.9526 (1.2); 4.3346 (0.7); 4.3238 (0.7); 4.3127 (0.7); 4.3018 (0.7); 4.2858 (0.9); 4.2750 (0.9); 4.2639 (0.8); 4.2529 (0.9); 4.2483 (0.9); 4.2373 (0.7); 4.2262 (0.7); 4.2153 (0.7); 4.1993 (0.9); 4.1885 (0.8); 4.1774 (0.9); 4.1665 (0.8); 3.9544 (0.8); 3.9366 (1.0); 3.9319 (1.0); 3.9140 (0.9); 3.9057 (0.7); 3.8877 (0.8); 3.8808 (1.2); 3.8629 (1.3); 3.8579 (1.0); 3.8400 (0.9); 3.8317 (0.8); 3.8138 (0.7); 3.8091 (0.8); 3.7912 (0.6); 3.4190 (9.4); 2.0425 (3.6); 1.5979 (7.7); 0.0485 (0.5); 0.0377 (15.5); 0.0267 (0.5)
I-678:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1223 (1.4); 9.1106 (3.0); 9.0989 (1.4); 8.7612 (5.2); 8.7588 (5.1); 8.7465 (4.3); 8.7441 (3.9); 8.7417 (4.2); 8.1158 (16.0); 8.0279 (4.3); 7.7569 (5.8); 7.5324 (1.7); 7.5289 (1.5); 7.5156 (5.5); 7.5121 (5.8); 7.5017 (9.2); 7.4850 (2.7); 7.3599 (2.5); 7.2497 (5.5); 7.1396 (2.7); 6.0466 (1.1); 6.0362 (2.2); 6.0262 (1.1); 5.9543 (1.1); 5.9440 (2.4); 5.9339 (1.1); 5.7612 (2.9); 3.9010 (1.9); 3.8899 (3.2); 3.8790 (1.7); 3.8547 (2.0); 3.8436 (3.3); 3.8327 (1.8); 3.3206 (88.8); 2.5151 (7.4); 2.5116 (15.6); 2.5080 (21.4); 2.5045 (15.4); 2.5010 (7.2)
I-679:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 12.0589 (2.7); 9.3335 (1.2); 9.3178 (2.6); 9.3023 (1.2); 7.7485 (1.0); 7.7288 (3.0); 7.7092 (2.9); 7.6889 (3.4); 7.6692 (1.5); 7.6174 (4.0); 7.5772 (2.3); 7.5574 (1.7); 7.3318 (3.5); 7.3118 (3.9); 7.0989 (4.2); 6.9637 (2.2); 6.9443 (2.0); 4.1789 (1.0); 4.1627 (1.0); 4.1411 (2.2); 4.1255 (2.1); 4.1034 (1.1); 4.0875 (1.1); 4.0381 (0.8); 4.0203 (0.8); 3.3268 (20.8); 2.6761 (0.4); 2.6714 (0.5); 2.6670 (0.4); 2.5547 (1.6); 2.5375 (2.8); 2.5250 (2.9); 2.5201 (3.6); 2.5114 (28.6); 2.5070 (58.9); 2.5025 (78.2); 2.4979 (56.3); 2.4935 (27.2); 2.4316 (11.1); 2.3338 (0.4); 2.3292 (0.5); 2.3248 (0.4); 2.2473 (16.0); 2.2225 (4.6); 2.2061 (2.0); 2.0748 (1.5); 1.9890 (3.4); 1.5552 (4.3); 1.5465 (4.8); 1.5381 (4.7); 1.1930 (1.0); 1.1753 (1.9); 1.1575 (1.0); -0.0002 (2.1)
I-680:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1982 (1.1); 9.1860 (2.3); 9.1737 (1.1); 8.7591 (4.0); 8.7565 (4.0); 8.7117 (3.4); 8.7094 (3.0); 8.7067 (3.4); 8.0604 (14.6); 7.9985 (3.4); 7.3628 (2.0); 7.3214 (3.7); 7.3055 (4.0); 7.2527 (4.4); 7.1426 (2.2); 7.0747 (4.1); 6.9219 (2.2); 6.9061 (2.0); 5.7611 (1.6); 4.1404 (1.1); 4.1283 (1.2); 4.1110 (2.5); 4.0987 (2.4); 4.0813 (1.2); 4.0691 (1.1); 3.3217 (52.2); 2.5150 (4.4); 2.5115 (8.9); 2.5078 (12.2); 2.5042 (8.8); 2.5006 (4.2); 2.4215 (11.2); 2.2141 (16.0)
I-681:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2825 (12.7); 7.8864 (0.8); 7.8689 (1.3); 7.8508 (0.8); 7.5355 (1.2); 7.5299 (1.4); 7.5150 (1.4); 7.5095 (2.8); 7.5041 (1.8); 7.4893 (1.5); 7.4836 (1.6); 7.3959 (1.2); 7.3903 (1.4); 7.3780 (3.8); 7.3681 (2.8); 7.3631 (2.1); 7.3514 (4.2); 7.3455 (2.5); 7.3395 (1.8); 7.2987 (7.0); 7.2741 (2.3); 7.2701 (2.3); 7.2474 (2.8); 7.2438 (3.0); 7.2209 (1.2); 7.2167 (1.3); 7.0646 (3.8); 6.9815 (2.1); 6.9549 (1.8); 4.3032 (2.1); 4.2832 (2.0); 4.2557 (4.3); 4.2358 (4.2); 4.2083 (2.2); 4.1883 (2.1); 3.4149 (7.7); 2.5155 (6.5); 2.5085 (11.8); 2.5011 (6.5); 2.3111 (16.0); 1.6076 (9.0); 0.1107 (1.0); 0.0389 (7.8)
I-682:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3079 (7.8); 7.8705 (0.8); 7.6200 (1.9); 7.6152 (3.0); 7.6105 (2.1); 7.4915 (3.3); 7.4856 (5.6); 7.4777 (1.3); 7.4659 (2.5); 7.4625 (2.9); 7.4564 (4.0); 7.4500 (2.7); 7.4154 (4.0); 7.3876 (1.7); 7.2988 (25.5); 6.1238 (0.6); 6.1136 (0.6); 6.0989 (0.7); 6.0890 (0.6); 5.9677 (0.6); 5.9575 (0.7); 5.9426 (0.7); 5.9327 (0.6); 4.3804 (0.4); 4.3703 (0.4); 4.3575 (0.4); 4.3470 (0.4); 4.3319 (0.4); 4.3216 (0.4); 4.3085 (0.4); 4.2985 (0.5); 4.2857 (0.4); 4.2755 (0.4); 4.2627 (0.4); 4.2521 (0.4); 4.2371 (0.5); 4.2267 (0.4); 4.2139 (0.4); 4.2034 (0.4); 3.8595 (0.4); 3.8432 (0.5); 3.8347 (0.4); 3.8182 (0.5); 3.8109 (0.4); 3.7922 (0.6); 3.7859 (0.5); 3.7759 (0.5); 3.7681 (0.6); 3.7504 (0.4); 3.7433 (0.4); 3.7268 (0.4); 3.7180 (0.4); 3.7019 (0.4); 1.7269 (0.3); 1.6292 (0.9); 1.5260 (0.4); 1.4614 (0.8); 1.3714 (0.9); 1.3225 (1.6); 1.2931 (16.0); 1.1409 (0.5); 1.1022 (0.4); 1.0383 (0.9); 1.0160 (0.8); 0.9184 (1.6); 0.8951 (1.2); 0.8643 (1.0); 0.8405 (0.5); 0.0491 (0.7); 0.0382 (29.4); 0.0273 (1.3)
I-683:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5496 (0.6); 7.5295 (3.1); 7.5146 (7.5); 7.4379 (4.1); 7.4075 (0.5); 7.3946 (1.6); 7.3880 (2.3); 7.3825 (2.0); 7.3727 (1.9); 7.3523 (3.4); 7.3323 (3.6); 7.2585 (8.3); 7.0533 (4.4); 6.9936 (2.5); 6.9737 (2.2); 6.5571 (1.1); 6.5423 (2.0); 6.5277 (1.2); 4.4407 (0.7); 4.4181 (1.8); 4.3990 (1.6); 4.3755 (1.8); 4.3526 (2.2); 4.3300 (0.9); 4.2287 (1.0); 4.2130 (1.0); 4.1924 (1.8); 4.1767 (1.8); 4.1546 (1.9); 4.1392 (1.7); 4.1187 (1.1); 4.1034 (1.0); 2.4717 (12.1); 2.2970 (16.0); 2.1487 (0.7); 2.1374 (0.6); 2.1296 (0.8); 2.1192 (1.3); 2.1005 (1.3); 2.0899 (0.9); 2.0821 (0.6); 2.0706 (0.8); 1.6653 (0.5); 1.6533 (0.6); 1.6450 (0.7); 1.6362 (1.2); 1.6249 (1.2); 1.6166 (1.2); 1.6051 (1.4); 1.5968 (0.8); 1.5880 (0.7); 1.5759 (0.7); 1.5505 (4.3); 1.3710 (0.6); 1.3611 (0.7); 1.3516 (1.0); 1.3409 (1.3); 1.3285 (1.0); 1.3202 (1.3); 1.3091 (1.1); 1.3000 (0.7); 1.2896 (0.6); 1.2562 (0.6); -0.0002 (7.6)
I-684:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5444 (0.6); 7.5244 (3.0); 7.5089 (7.6); 7.4362 (4.1); 7.4062 (0.5); 7.3933 (1.7); 7.3868 (2.3); 7.3812 (1.9); 7.3709 (1.9); 7.3574 (3.5); 7.3373 (3.6); 7.2587 (10.5); 7.0455 (4.4); 6.9806 (2.4); 6.9610 (2.2); 6.5190 (1.0); 6.5041 (1.9); 6.4891 (1.1); 6.0354 (0.4); 6.0213 (0.9); 6.0084 (0.9); 5.9948 (1.3); 5.9790 (1.4); 5.9656 (1.1); 5.9523 (1.2); 5.9383 (0.6); 5.4883 (2.5); 5.4455 (2.2); 5.3691 (2.8); 5.3430 (2.6); 4.8212 (5.7); 4.8073 (5.6); 4.2273 (1.5); 4.2118 (1.6); 4.1901 (3.3); 4.1746 (3.2); 4.1529 (1.8); 4.1374 (1.6); 2.4769 (11.9); 2.3153 (0.6); 2.2904 (16.0); 1.5495 (4.8); 1.2561 (1.0); 0.8445 (0.4); -0.0002 (10.0)
I-685:1 H-NMR(300.2 MHz, CDCl3): δ= 12.5375 (0.7); 7.9974 (8.5); 7.5864 (3.8); 7.5600 (0.6); 7.5205 (2.2); 7.4964 (2.9); 7.4681 (1.3); 7.4414 (3.4); 7.4275 (3.2); 7.4018 (2.4); 7.3818 (3.2); 7.3560 (3.5); 7.2991 (9.5); 7.1637 (0.4); 7.1512 (0.4); 7.1267 (2.5); 7.1153 (2.7); 7.1016 (3.0); 7.0693 (5.5); 4.6129 (1.2); 4.5648 (2.4); 4.5173 (1.3); 3.1447 (0.4); 2.9206 (0.4); 2.9063 (0.7); 2.8942 (1.1); 2.8826 (1.6); 2.8702 (1.7); 2.8584 (1.2); 2.8466 (0.7); 2.5304 (1.0); 2.5009 (11.0); 2.4262 (0.3); 2.4015 (0.5); 2.3668 (16.0); 2.3199 (0.6); 1.7102 (0.3); 1.4595 (0.4); 1.3693 (0.5); 1.3212 (0.8); 1.2922 (1.6); 0.9217 (1.1); 0.8983 (4.4); 0.8791 (4.4); 0.8568 (1.6); 0.8278 (0.4); 0.6624 (1.3); 0.6390 (3.9); 0.6330 (3.6); 0.6090 (1.0); 0.0471 (0.4); 0.0363 (9.7); 0.0258 (0.5)
I-686:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2537 (10.6); 7.9221 (0.9); 7.9115 (1.5); 7.9007 (0.8); 7.3418 (3.7); 7.3258 (4.0); 7.2774 (1.0); 7.2733 (1.3); 7.2596 (15.3); 7.2490 (5.2); 7.2443 (2.4); 7.2342 (4.1); 7.2180 (1.6); 7.1956 (1.8); 7.1917 (1.6); 7.1830 (1.7); 7.1804 (1.5); 7.1773 (1.8); 7.1696 (1.0); 7.1640 (0.8); 7.0345 (3.9); 6.9494 (2.2); 6.9335 (1.9); 5.2978 (0.4); 4.2480 (1.2); 4.2421 (1.2); 4.2361 (1.2); 4.2302 (1.2); 4.2193 (2.2); 4.2132 (2.2); 4.2074 (2.1); 4.2013 (2.0); 4.1904 (1.2); 4.1844 (1.3); 4.1784 (1.1); 4.1726 (1.2); 4.1585 (2.2); 4.1531 (2.7); 4.1456 (2.0); 3.2218 (2.9); 3.2135 (3.0); 3.2107 (3.1); 3.2024 (2.8); 2.8450 (3.0); 2.8400 (3.0); 2.8338 (2.8); 2.8288 (2.7); 2.4769 (11.4); 2.2801 (16.0); 1.5477 (11.6); 0.0060 (1.1); -0.0002 (16.1); -0.0067 (0.5)
I-687:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5896 (0.6); 7.5634 (3.2); 7.5423 (9.3); 7.5250 (0.8); 7.4674 (4.3); 7.4503 (0.6); 7.4329 (1.9); 7.4235 (2.9); 7.4161 (2.2); 7.4056 (4.9); 7.3797 (4.2); 7.2992 (21.5); 7.1133 (1.0); 7.0807 (4.9); 7.0230 (2.4); 6.9960 (2.1); 6.5335 (0.5); 5.3379 (0.5); 4.5686 (4.2); 4.5599 (3.2); 4.5543 (4.6); 4.5481 (3.3); 4.5398 (4.5); 4.4309 (0.8); 4.4077 (2.2); 4.3844 (2.3); 4.3611 (0.8); 4.2787 (0.6); 4.2642 (1.8); 4.2435 (1.7); 4.2286 (1.3); 4.2145 (3.8); 4.1937 (3.6); 4.1788 (0.8); 4.1657 (2.5); 4.1436 (2.7); 4.1195 (0.4); 3.8071 (4.5); 3.7988 (3.3); 3.7925 (4.6); 3.7869 (3.4); 3.7782 (4.3); 3.6217 (2.5); 3.5984 (7.7); 3.5751 (7.8); 3.5518 (2.6); 2.5224 (13.2); 2.5159 (10.0); 2.3750 (0.4); 2.3354 (5.0); 2.3148 (15.3); 2.0810 (4.4); 1.6136 (9.0); 1.4922 (2.3); 1.4689 (4.7); 1.4456 (2.3); 1.3199 (1.3); 1.2959 (2.8); 1.2722 (1.3); 1.2292 (8.0); 1.2059 (16.0); 1.1825 (7.7); 0.1085 (0.6); 0.0490 (0.6); 0.0381 (17.4); 0.0274 (0.7)
I-688:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6091 (0.4); 7.5823 (3.2); 7.5786 (3.2); 7.5733 (3.0); 7.5651 (6.9); 7.5621 (7.7); 7.4769 (3.7); 7.4546 (0.5); 7.4401 (1.6); 7.4278 (2.1); 7.4210 (2.0); 7.4102 (1.6); 7.3935 (3.7); 7.3667 (4.1); 7.2990 (16.0); 7.1021 (4.1); 7.0394 (2.2); 7.0129 (1.9); 6.7150 (1.0); 6.6941 (1.9); 6.6737 (1.0); 6.4974 (0.4); 6.4910 (0.7); 6.4843 (1.0); 6.4777 (1.0); 6.4712 (0.7); 6.4646 (0.4); 6.4449 (0.7); 6.4385 (1.0); 6.4319 (1.4); 6.4251 (1.4); 6.4186 (1.0); 6.4120 (0.6); 6.2320 (0.4); 6.2178 (0.6); 6.2113 (1.2); 6.2047 (0.7); 6.1972 (0.7); 6.1904 (1.2); 6.1838 (0.8); 6.1694 (0.6); 6.1589 (0.8); 6.1522 (0.5); 6.1446 (0.4); 6.1378 (0.8); 6.1314 (0.4); 4.9230 (0.8); 4.9146 (2.6); 4.9062 (4.0); 4.8993 (4.0); 4.8940 (3.9); 4.8856 (2.5); 4.8768 (0.8); 4.2853 (1.7); 4.2644 (1.6); 4.2358 (3.5); 4.2147 (3.4); 4.1860 (1.8); 4.1650 (1.8); 2.5172 (11.8); 2.3478 (16.0); 1.6035 (12.6); 0.0494 (0.5); 0.0385 (14.8); 0.0276 (0.6)
I-689:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6272 (1.4); 7.6097 (1.9); 7.5080 (0.9); 7.4524 (0.4); 7.4438 (0.4); 7.4370 (0.5); 7.4307 (0.5); 7.2990 (18.0); 7.2384 (11.6); 4.1937 (0.9); 4.1705 (1.9); 4.1480 (1.1); 3.1693 (0.8); 3.1483 (1.2); 3.1434 (1.2); 3.1267 (0.5); 3.1194 (0.5); 2.2299 (8.0); 1.5857 (16.0); 1.3041 (0.5); 0.9201 (0.5); 0.1072 (1.5); 0.0487 (0.6); 0.0379 (19.5); 0.0270 (0.8)
I-690:1 H-NMR(300.2 MHz, CDCl3): δ= 8.6582 (2.0); 8.6544 (2.1); 8.5940 (1.9); 8.5858 (1.8); 7.7669 (1.7); 7.3935 (1.9); 7.3668 (2.2); 7.2989 (6.9); 7.0993 (2.2); 7.0343 (1.2); 7.0081 (1.0); 6.9628 (1.2); 6.7774 (2.4); 6.7603 (0.5); 6.7391 (1.0); 6.7186 (0.5); 6.5921 (1.2); 4.2916 (0.9); 4.2708 (0.9); 4.2425 (2.0); 4.2217 (1.9); 4.1933 (1.0); 4.1725 (1.0); 2.5285 (6.3); 2.3985 (16.0); 2.3608 (2.0); 2.3427 (8.5); 1.6419 (1.0); 0.0370 (8.2)
I-691:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5678 (0.6); 8.1513 (5.1); 7.6233 (1.5); 7.6173 (1.3); 7.6125 (1.3); 7.6053 (3.6); 7.6021 (3.8); 7.5046 (1.8); 7.4665 (0.7); 7.4549 (1.0); 7.4483 (0.9); 7.4363 (0.7); 7.4282 (0.4); 7.2988 (2.7); 7.1752 (2.9); 7.0357 (3.1); 4.3377 (1.8); 4.3250 (1.6); 4.3203 (2.2); 4.3133 (1.6); 4.3019 (2.2); 4.0210 (1.1); 4.0096 (0.9); 4.0027 (2.2); 3.9913 (1.1); 3.9848 (2.0); 3.9668 (0.9); 2.8347 (0.6); 2.7507 (16.0); 2.0380 (0.5); 1.9595 (11.8); 1.8550 (0.8); 0.1052 (0.6); 0.0330 (2.7)
I-692:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4600 (0.5); 7.4487 (0.5); 7.4387 (1.0); 7.4274 (1.1); 7.4168 (0.5); 7.4060 (0.6); 7.3827 (1.7); 7.3561 (2.0); 7.2988 (4.5); 7.1927 (2.8); 7.1884 (1.7); 7.1819 (1.5); 7.1786 (1.6); 7.1673 (2.6); 7.0769 (1.9); 6.9780 (1.0); 6.9511 (0.9); 6.9039 (1.0); 6.8665 (1.0); 6.8448 (1.1); 6.8074 (1.1); 6.5167 (0.4); 6.4959 (0.8); 6.4752 (0.4); 5.9049 (1.8); 5.9023 (1.8); 5.8459 (1.6); 5.8433 (1.6); 5.4788 (1.8); 5.4763 (1.8); 5.4415 (1.6); 5.4389 (1.7); 4.2890 (0.9); 4.2680 (0.9); 4.2411 (1.9); 4.2200 (1.8); 4.1931 (1.0); 4.1720 (0.9); 2.5285 (5.8); 2.5219 (3.3); 2.3769 (16.0); 2.3205 (7.8); 1.6276 (0.7); 0.0384 (4.5)
I-693:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.8691 (0.7); 8.8549 (1.4); 8.8406 (0.7); 7.9625 (0.9); 7.5001 (0.7); 7.4793 (1.4); 7.4587 (0.9); 7.1428 (3.7); 7.1348 (4.1); 7.0529 (1.8); 7.0338 (2.1); 6.9450 (2.6); 6.8325 (1.5); 6.8135 (1.2); 3.5181 (0.9); 3.5016 (2.1); 3.4850 (2.1); 3.4687 (0.9); 3.3123 (14.1); 2.9001 (4.6); 2.8048 (1.6); 2.7871 (3.0); 2.7694 (1.4); 2.7413 (4.4); 2.5101 (8.2); 2.2591 (16.0); 2.1998 (10.3); 1.5603 (0.5); 1.5416 (1.7); 1.5242 (0.6); 1.5117 (0.5); 1.4934 (1.7); 1.4757 (0.6); 1.2196 (0.6); 1.1990 (2.1); 1.1809 (2.0); 1.1596 (0.4)
I-694:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.8749 (0.9); 8.8607 (1.7); 8.8465 (0.8); 7.9622 (0.8); 7.4582 (0.9); 7.4384 (1.9); 7.4171 (1.2); 7.2123 (2.0); 7.1929 (1.7); 7.1188 (5.4); 7.1021 (1.7); 7.0546 (2.1); 7.0355 (2.5); 6.9485 (3.1); 6.8385 (1.7); 6.8200 (1.4); 3.5129 (1.0); 3.4960 (2.4); 3.4796 (2.4); 3.4629 (1.0); 3.3125 (20.4); 3.1136 (0.5); 3.0929 (0.6); 3.0833 (0.9); 3.0609 (0.9); 3.0305 (0.5); 2.9001 (4.6); 2.8035 (1.9); 2.7857 (3.4); 2.7679 (1.7); 2.7413 (4.4); 2.5099 (10.4); 2.2622 (15.5); 2.2565 (16.0); 2.2025 (12.2); 2.0638 (0.4); 2.0441 (0.6); 2.0296 (0.6); 2.0135 (1.0); 1.9984 (1.1); 1.9836 (1.2); 1.9709 (1.3); 1.9624 (0.7); 1.9503 (0.8); 1.9398 (0.6)
I-695:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3120 (1.0); 9.2967 (2.1); 9.2810 (1.0); 7.9623 (1.6); 7.4567 (1.2); 7.4360 (2.3); 7.4152 (1.6); 7.3407 (2.6); 7.3207 (2.9); 7.2117 (2.4); 7.1924 (2.0); 7.1115 (8.5); 7.0956 (2.4); 7.0092 (2.0); 6.9896 (1.8); 4.1588 (0.9); 4.1437 (1.0); 4.1213 (2.0); 4.1059 (1.9); 4.0837 (1.1); 4.0680 (0.9); 3.3123 (28.2); 3.1148 (0.6); 3.0926 (0.8); 3.0832 (1.1); 3.0618 (1.1); 3.0525 (0.8); 3.0307 (0.7); 2.9001 (8.7); 2.7413 (8.1); 2.5101 (13.6); 2.4424 (9.5); 2.2632 (12.7); 2.1950 (16.0); 2.0440 (0.6); 2.0306 (0.8); 2.0140 (1.1); 1.9982 (1.3); 1.9867 (1.1); 1.9768 (1.0); 1.9661 (1.5); 1.9546 (0.8); 1.9438 (0.9); 1.9330 (0.8); 1.9236 (0.3)
I-696:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1849 (1.4); 9.1700 (2.6); 9.1557 (1.3); 7.9623 (2.6); 7.6621 (4.4); 7.5590 (2.1); 7.5530 (2.3); 7.5380 (2.7); 7.5320 (2.8); 7.4599 (1.5); 7.4408 (3.3); 7.4201 (2.1); 7.3963 (1.7); 7.3826 (2.1); 7.3669 (1.3); 7.2172 (3.3); 7.1981 (2.7); 7.1149 (9.4); 7.0971 (2.7); 6.0529 (0.9); 6.0403 (1.7); 6.0283 (0.9); 5.9364 (0.9); 5.9251 (1.8); 5.9134 (0.9); 3.9351 (1.5); 3.9226 (2.5); 3.9093 (1.6); 3.8748 (1.5); 3.8630 (2.5); 3.8497 (1.5); 3.3118 (43.7); 3.1165 (0.8); 3.0955 (1.1); 3.0859 (1.5); 3.0643 (1.6); 3.0333 (0.9); 2.9001 (14.2); 2.7412 (13.3); 2.5099 (20.7); 2.2518 (16.0); 2.0659 (0.4); 2.0454 (0.8); 2.0320 (1.0); 2.0153 (1.6); 2.0010 (1.9); 1.9908 (1.5); 1.9831 (1.6); 1.9697 (2.3); 1.9598 (1.2); 1.9483 (1.3); 1.9375 (1.1); 1.9177 (0.3)
I-697:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5955 (0.4); 7.5793 (0.5); 7.3835 (0.5); 7.3559 (0.5); 7.3037 (7.4); 7.2204 (0.8); 7.0712 (0.5); 7.0436 (0.4); 6.2394 (0.5); 3.0793 (0.3); 2.0884 (0.8); 1.6162 (0.4); 1.4653 (0.4); 1.3730 (0.7); 1.3260 (1.9); 1.2979 (16.0); 1.1958 (0.6); 1.1699 (0.5); 1.1454 (0.7); 1.0889 (0.4); 0.9233 (1.6); 0.8982 (1.8); 0.8744 (1.3); 0.7569 (0.4); 0.0427 (6.8)
I-698:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2690 (0.6); 8.2633 (11.7); 7.9122 (1.1); 7.9032 (1.0); 7.5516 (3.6); 7.3767 (0.7); 7.3574 (10.4); 7.3408 (0.6); 7.2970 (0.6); 7.2930 (0.7); 7.2894 (0.6); 7.2850 (0.9); 7.2808 (1.4); 7.2771 (1.4); 7.2733 (1.6); 7.2687 (2.4); 7.2611 (13.1); 7.2563 (1.6); 7.2483 (3.7); 7.2322 (1.4); 7.2046 (1.6); 7.2008 (1.6); 7.1920 (1.6); 7.1891 (1.4); 7.1863 (1.6); 7.1785 (0.9); 7.1730 (0.8); 6.0574 (1.0); 6.0509 (1.1); 6.0439 (1.1); 6.0374 (1.0); 5.9645 (1.0); 5.9580 (1.1); 5.9510 (1.1); 5.9445 (1.0); 5.2983 (16.0); 4.2748 (0.3); 4.2702 (0.4); 4.2685 (0.4); 4.2637 (0.4); 4.2618 (0.4); 4.2571 (0.4); 4.2553 (0.4); 4.2507 (0.4); 4.2454 (0.4); 4.2409 (0.5); 4.2392 (0.5); 4.2343 (0.5); 4.2325 (0.5); 4.2277 (0.5); 4.2259 (0.6); 4.2217 (0.6); 4.2187 (0.5); 4.2120 (0.4); 4.2100 (0.5); 4.2054 (0.5); 4.2036 (0.5); 4.1989 (0.4); 4.1937 (0.5); 4.1892 (0.5); 4.1874 (0.5); 4.1826 (0.5); 4.1807 (0.6); 4.1759 (0.5); 4.1742 (0.6); 4.1695 (0.5); 4.1631 (2.0); 4.1577 (2.4); 4.1555 (2.4); 4.1502 (2.1); 3.8831 (0.5); 3.8723 (0.6); 3.8699 (0.6); 3.8590 (0.6); 3.8538 (0.5); 3.8396 (0.9); 3.8289 (0.9); 3.8141 (0.6); 3.8092 (0.5); 3.7979 (0.6); 3.7849 (0.4); 3.2235 (2.7); 3.2153 (2.8); 3.2124 (3.2); 3.2041 (2.9); 2.8493 (1.9); 2.8479 (2.1); 2.8444 (2.1); 2.8429 (2.2); 2.8382 (2.0); 2.8367 (2.1); 2.8332 (2.0); 2.8317 (2.1); 2.1690 (0.4); 2.0039 (0.6); 1.5574 (3.6); 0.0063 (0.4); -0.0002 (13.2); -0.0067 (0.8)
I-699:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2424 (10.1); 8.0626 (1.0); 8.0518 (1.6); 8.0410 (0.9); 7.3970 (2.1); 7.3811 (4.2); 7.3652 (2.5); 7.3216 (3.5); 7.3056 (3.7); 7.2563 (3.1); 7.0529 (2.4); 7.0483 (2.6); 7.0370 (5.9); 7.0129 (2.7); 6.9974 (2.4); 6.9460 (2.3); 6.9301 (2.1); 6.9011 (3.0); 6.8977 (4.0); 4.7299 (0.8); 4.7243 (1.1); 4.7197 (0.9); 4.7177 (1.0); 4.7119 (1.0); 4.7075 (0.7); 4.6027 (0.8); 4.5971 (1.1); 4.5925 (0.9); 4.5905 (1.0); 4.5847 (1.0); 4.5803 (0.7); 4.2249 (1.7); 4.2130 (1.6); 4.1959 (3.5); 4.1841 (3.4); 4.1669 (1.8); 4.1550 (1.6); 2.4701 (12.0); 2.4439 (1.1); 2.4302 (0.7); 2.4263 (0.7); 2.4222 (0.7); 2.4184 (0.7); 2.4077 (0.6); 2.4041 (0.6); 2.2937 (16.0); 1.6066 (0.7); 1.6007 (0.8); 1.5919 (0.9); 1.5844 (1.3); 1.5781 (1.3); 1.5694 (0.9); 1.5621 (1.1); 1.5557 (0.7); 1.5469 (0.8); 1.5396 (1.0); 1.5332 (0.7); 1.5244 (0.7); 1.5185 (0.6); 1.1587 (0.7); 1.1444 (1.5); 1.1378 (0.9); 1.1316 (1.5); 1.1235 (1.6); 1.1172 (0.8); 1.1107 (1.4); 1.0963 (0.6); -0.0002 (3.6)
I-700:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2451 (11.8); 8.1682 (0.5); 8.0935 (1.0); 8.0828 (1.5); 8.0721 (0.9); 7.4200 (2.2); 7.4041 (4.7); 7.3882 (2.8); 7.3249 (3.6); 7.3089 (3.8); 7.2573 (6.8); 7.2513 (2.8); 7.2351 (2.2); 7.1177 (3.9); 7.0717 (2.4); 7.0684 (2.0); 7.0672 (1.9); 7.0567 (2.0); 7.0555 (2.1); 7.0522 (1.9); 7.0508 (1.8); 7.0253 (4.0); 6.9354 (2.2); 6.9195 (1.9); 5.2937 (0.4); 4.8964 (0.8); 4.8904 (0.8); 4.8843 (1.3); 4.8782 (1.3); 4.8721 (0.8); 4.8661 (0.7); 4.7650 (0.8); 4.7585 (0.8); 4.7531 (1.2); 4.7466 (1.2); 4.7409 (0.8); 4.7346 (0.7); 4.2246 (1.4); 4.2127 (1.4); 4.1972 (2.6); 4.1954 (2.6); 4.1853 (2.5); 4.1834 (2.5); 4.1667 (1.4); 4.1547 (1.3); 2.4685 (11.4); 2.3227 (0.8); 2.2785 (16.0); 2.1437 (0.5); 2.1315 (1.0); 2.1227 (0.8); 2.1196 (0.8); 2.1155 (1.2); 2.1115 (1.2); 2.1040 (0.7); 2.0990 (0.7); 2.0954 (1.0); 2.0833 (0.5); 1.5687 (0.5); 1.3435 (0.5); 1.3374 (0.6); 1.3281 (1.4); 1.3221 (1.4); 1.3124 (1.1); 1.3061 (1.3); 1.3048 (1.4); 1.2999 (0.6); 1.2928 (1.5); 1.2894 (1.0); 1.2842 (2.4); 1.2778 (3.0); 1.2721 (1.4); 1.2685 (2.0); 1.2666 (1.8); 1.2622 (1.6); 1.2573 (1.8); 1.2512 (0.6); 1.2459 (1.1); 1.2424 (0.5); 1.2403 (0.4); 1.2307 (0.4); 0.0062 (0.5); -0.0002 (7.5)
I-701:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2623 (16.0); 8.2541 (0.3); 7.9194 (1.6); 7.9095 (1.5); 7.4290 (5.6); 7.4122 (6.7); 7.4039 (3.2); 7.4014 (5.3); 7.3998 (5.2); 7.3979 (5.4); 7.3240 (0.4); 7.3087 (0.5); 7.2987 (1.0); 7.2950 (1.4); 7.2917 (1.3); 7.2873 (1.4); 7.2859 (1.4); 7.2826 (2.2); 7.2791 (2.3); 7.2755 (2.4); 7.2699 (2.9); 7.2613 (18.1); 7.2460 (5.4); 7.2298 (2.8); 7.2226 (3.5); 7.2210 (3.4); 7.2032 (4.6); 7.1903 (2.5); 7.1864 (2.6); 7.1761 (1.4); 7.1714 (1.2); 6.0717 (1.3); 6.0653 (1.5); 6.0581 (1.4); 6.0517 (1.4); 5.9788 (1.3); 5.9724 (1.4); 5.9652 (1.4); 5.9588 (1.3); 4.2724 (0.6); 4.2685 (0.6); 4.2661 (0.7); 4.2620 (0.6); 4.2594 (0.7); 4.2554 (0.7); 4.2529 (0.7); 4.2489 (0.6); 4.2431 (0.7); 4.2392 (0.8); 4.2368 (0.8); 4.2326 (0.8); 4.2301 (0.8); 4.2260 (0.8); 4.2235 (0.9); 4.2200 (1.1); 4.2168 (0.8); 4.2141 (0.8); 4.2101 (0.7); 4.2074 (0.8); 4.2034 (0.8); 4.2009 (0.8); 4.1969 (0.7); 4.1911 (0.8); 4.1872 (0.9); 4.1847 (0.9); 4.1807 (0.9); 4.1780 (0.9); 4.1740 (1.0); 4.1715 (1.0); 4.1676 (0.9); 4.1595 (3.0); 4.1541 (3.5); 4.1522 (3.5); 4.1466 (2.8); 3.8861 (0.9); 3.8753 (1.0); 3.8728 (1.0); 3.8619 (1.0); 3.8568 (0.9); 3.8426 (1.5); 3.8319 (1.5); 3.8173 (0.9); 3.8123 (0.9); 3.8010 (0.9); 3.7881 (0.6); 3.2223 (4.1); 3.2142 (4.2); 3.2112 (4.5); 3.2030 (4.1); 2.8460 (3.6); 2.8410 (3.6); 2.8348 (3.4); 2.8299 (3.1); 2.0036 (7.3); 1.5730 (0.5); 0.0708 (0.5); 0.0063 (0.9); -0.0002 (16.8); -0.0068 (0.6)
I-702:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3851 (2.8); 7.3587 (3.4); 7.2984 (13.8); 7.2378 (0.6); 7.2188 (1.0); 7.2006 (0.6); 7.0851 (0.6); 7.0698 (4.8); 7.0579 (7.2); 7.0551 (7.2); 7.0494 (6.4); 7.0283 (0.7); 6.9841 (2.5); 6.9581 (2.2); 6.8011 (0.7); 6.7958 (1.0); 6.7816 (1.4); 6.7741 (1.6); 6.7633 (1.4); 6.7530 (0.8); 6.7425 (0.6); 5.2470 (0.5); 5.2309 (1.7); 5.2148 (1.7); 5.1987 (0.5); 5.0947 (0.7); 5.0787 (2.1); 5.0627 (2.1); 5.0468 (0.6); 4.3681 (0.7); 4.3543 (0.7); 4.3458 (0.9); 4.3321 (0.9); 4.3232 (1.0); 4.3099 (1.0); 4.2970 (0.8); 4.2849 (0.8); 4.2681 (0.4); 4.2550 (1.1); 4.2465 (1.0); 4.2332 (2.2); 4.2197 (0.8); 4.2050 (3.3); 4.1844 (2.9); 4.1708 (1.2); 4.1563 (1.2); 4.1474 (0.8); 4.1360 (1.2); 4.1275 (0.6); 4.1214 (0.6); 3.9999 (1.2); 3.9713 (1.9); 3.9472 (1.5); 3.8567 (1.6); 3.8412 (1.5); 3.8282 (1.1); 3.8126 (1.0); 3.6642 (0.5); 3.6461 (1.7); 3.6349 (0.8); 3.6227 (1.7); 3.6176 (1.7); 3.6035 (1.8); 3.5941 (1.6); 3.5833 (1.1); 3.5732 (1.1); 3.5696 (1.0); 3.5575 (0.9); 3.5509 (0.8); 3.5343 (0.8); 3.4834 (0.7); 3.4652 (1.3); 3.4469 (0.7); 3.4396 (0.6); 3.4212 (0.9); 3.4028 (0.4); 2.6244 (12.2); 2.6034 (14.7); 2.5056 (11.7); 2.3225 (16.0); 2.2901 (0.4); 2.1537 (0.4); 2.1356 (0.9); 2.1243 (1.0); 2.1078 (1.8); 2.0905 (1.1); 2.0822 (1.3); 2.0621 (0.5); 1.6304 (10.3); 1.4748 (8.6); 1.4588 (8.5); 1.4306 (7.1); 1.4145 (7.0); 1.2964 (0.4); 1.0541 (0.9); 1.0384 (3.2); 1.0320 (3.2); 1.0096 (3.2); 1.0045 (3.0); 0.9911 (1.2); 0.8029 (1.4); 0.7868 (4.1); 0.7836 (4.1); 0.7712 (3.6); 0.7653 (4.1); 0.7492 (1.1); 0.1076 (0.9); 0.0480 (0.6); 0.0372 (15.4); 0.0264 (0.6)
I-703:1 H-NMR(499.9 MHz, CDCl3): δ= 7.4223 (2.3); 7.4056 (2.7); 7.3905 (2.9); 7.2599 (7.7); 7.1846 (1.6); 7.1812 (1.7); 7.1679 (1.4); 7.1645 (1.5); 7.0956 (0.6); 7.0793 (2.0); 7.0648 (3.5); 7.0523 (1.6); 7.0393 (0.5); 6.8187 (0.7); 6.8133 (0.7); 6.8051 (1.4); 6.8015 (1.3); 6.7897 (0.8); 6.7871 (0.8); 6.4753 (0.7); 6.4637 (1.2); 6.4522 (0.7); 6.0293 (0.6); 6.0230 (0.7); 6.0166 (0.7); 6.0102 (0.6); 5.9367 (0.6); 5.9304 (0.7); 5.9239 (0.7); 5.9176 (0.6); 4.1884 (0.3); 4.1820 (0.3); 4.1755 (0.3); 4.1655 (0.4); 4.1590 (0.4); 4.1526 (0.4); 4.1454 (0.6); 4.1383 (0.4); 4.1319 (0.4); 4.1252 (0.3); 4.1153 (0.4); 4.1088 (0.4); 4.1024 (0.4); 4.0959 (0.4); 3.9534 (0.4); 3.9409 (0.6); 3.9283 (0.4); 3.9244 (0.4); 3.9111 (0.6); 3.9077 (0.5); 3.8949 (0.7); 3.8820 (0.4); 3.8781 (0.4); 3.8652 (0.5); 2.4102 (16.0); 2.0857 (0.6); 2.0788 (0.7); 2.0688 (1.2); 2.0588 (0.8); 2.0521 (0.7); 2.0416 (0.4); 1.5509 (5.2); 1.0277 (0.7); 1.0180 (2.2); 1.0148 (2.5); 1.0013 (2.4); 0.9980 (2.5); 0.9888 (1.0); 0.7745 (0.8); 0.7626 (3.0); 0.7521 (3.1); 0.7422 (0.9); -0.0002 (9.3)
I-704:1 H-NMR(499.9 MHz, CDCl3): δ= 7.4216 (2.6); 7.4048 (2.9); 7.3897 (3.1); 7.2600 (7.3); 7.1840 (1.8); 7.1806 (1.9); 7.1672 (1.5); 7.1639 (1.6); 7.0947 (0.8); 7.0784 (2.2); 7.0640 (3.6); 7.0515 (1.6); 7.0386 (0.5); 6.8178 (0.8); 6.8126 (0.9); 6.8043 (1.5); 6.8010 (1.4); 6.7864 (0.8); 6.4854 (0.8); 6.4739 (1.3); 6.4623 (0.7); 6.0282 (0.7); 6.0219 (0.7); 6.0154 (0.7); 6.0091 (0.6); 5.9356 (0.7); 5.9293 (0.7); 5.9229 (0.7); 5.9165 (0.6); 4.1927 (0.4); 4.1862 (0.4); 4.1800 (0.4); 4.1733 (0.4); 4.1634 (0.5); 4.1569 (0.5); 4.1505 (0.5); 4.1432 (0.7); 4.1362 (0.4); 4.1298 (0.4); 4.1231 (0.4); 4.1132 (0.4); 4.1066 (0.4); 4.1004 (0.4); 4.0938 (0.4); 3.9523 (0.4); 3.9397 (0.7); 3.9273 (0.5); 3.9234 (0.4); 3.9100 (0.6); 3.9068 (0.6); 3.8938 (0.8); 3.8810 (0.4); 3.8772 (0.4); 3.8640 (0.5); 2.4086 (16.0); 2.0955 (0.4); 2.0849 (0.7); 2.0779 (0.8); 2.0681 (1.3); 2.0581 (0.8); 2.0514 (0.7); 2.0408 (0.3); 1.5545 (4.5); 1.0273 (1.0); 1.0176 (2.5); 1.0145 (2.8); 1.0009 (2.5); 0.9976 (2.6); 0.9884 (0.9); 0.7740 (1.2); 0.7620 (3.3); 0.7516 (3.2); 0.7417 (0.8); -0.0002 (8.0)
I-705:1 H-NMR(499.9 MHz, CDCl3): δ= 8.0436 (16.0); 7.9953 (1.3); 7.9845 (2.0); 7.9737 (1.3); 7.6229 (1.2); 7.6073 (4.0); 7.5918 (8.6); 7.5750 (1.2); 7.5437 (6.8); 7.4813 (5.2); 7.4139 (2.1); 7.4100 (3.5); 7.4060 (2.2); 7.3955 (2.6); 7.3734 (1.8); 7.3700 (1.6); 7.3566 (6.6); 7.3533 (6.8); 7.3453 (10.0); 7.3286 (2.4); 7.2606 (13.7); 6.0505 (1.4); 6.0441 (1.6); 6.0364 (1.6); 6.0299 (1.4); 5.9573 (1.4); 5.9508 (1.6); 5.9431 (1.6); 5.9366 (1.4); 4.2788 (0.8); 4.2722 (0.8); 4.2654 (0.8); 4.2588 (0.8); 4.2495 (0.9); 4.2429 (1.0); 4.2361 (0.9); 4.2295 (1.0); 4.2249 (0.9); 4.2183 (0.8); 4.2114 (0.9); 4.2049 (0.8); 4.1955 (1.0); 4.1889 (0.9); 4.1822 (0.9); 4.1756 (0.8); 3.8351 (0.9); 3.8247 (1.0); 3.8209 (0.9); 3.8105 (1.0); 3.8058 (0.9); 3.7921 (1.6); 3.7817 (1.6); 3.7680 (0.9); 3.7633 (0.9); 3.7529 (0.8); 3.7491 (0.8); 3.7388 (0.7); 2.2373 (0.8); 2.2271 (1.7); 2.2213 (1.8); 2.2161 (1.3); 2.2113 (3.3); 2.2043 (1.3); 2.2009 (1.8); 2.1951 (1.8); 2.1848 (0.9); 1.5590 (3.4); 1.2846 (0.4); 1.2558 (0.7); 1.1770 (0.9); 1.1644 (3.5); 1.1590 (7.0); 1.1550 (6.8); 1.1495 (6.1); 1.1455 (7.2); 1.1421 (7.6); 1.1366 (3.5); 1.1300 (4.0); 1.1251 (5.4); 1.1201 (3.3); 1.1081 (0.9); 0.8456 (0.4); 0.8394 (0.4); 0.0060 (0.8); -0.0002 (16.2); -0.0067 (0.7)
I-706:1 H-NMR(499.9 MHz, CDCl3): δ= 8.0436 (16.0); 7.9848 (2.8); 7.6231 (1.4); 7.6076 (4.6); 7.5923 (10.4); 7.5779 (2.0); 7.5755 (2.0); 7.5438 (8.2); 7.4816 (6.5); 7.4379 (0.4); 7.4285 (0.5); 7.4136 (3.0); 7.4100 (4.2); 7.4061 (2.8); 7.3956 (3.4); 7.3734 (2.4); 7.3702 (2.0); 7.3567 (8.3); 7.3534 (7.6); 7.3455 (11.0); 7.3288 (3.0); 7.2607 (13.2); 6.0507 (1.6); 6.0442 (1.8); 6.0365 (1.8); 6.0301 (1.7); 5.9573 (1.6); 5.9509 (1.8); 5.9432 (1.9); 5.9369 (1.7); 4.2788 (0.9); 4.2723 (1.0); 4.2655 (1.0); 4.2589 (1.0); 4.2495 (1.1); 4.2430 (1.1); 4.2362 (1.1); 4.2295 (1.2); 4.2250 (1.1); 4.2184 (1.0); 4.2115 (1.1); 4.2050 (1.0); 4.1956 (1.1); 4.1890 (1.1); 4.1822 (1.1); 4.1757 (1.0); 3.8352 (0.9); 3.8247 (1.2); 3.8212 (1.1); 3.8106 (1.2); 3.8061 (1.0); 3.7924 (1.9); 3.7819 (2.0); 3.7680 (1.2); 3.7635 (1.1); 3.7529 (1.2); 3.7494 (1.0); 3.7390 (0.9); 2.2374 (0.9); 2.2272 (1.9); 2.2214 (2.1); 2.2114 (3.6); 2.2043 (2.0); 2.2010 (2.2); 2.1952 (2.1); 2.1850 (1.2); 1.5589 (2.7); 1.3340 (0.4); 1.2846 (0.6); 1.2563 (1.4); 1.2145 (0.4); 1.2023 (0.4); 1.1770 (1.1); 1.1637 (4.7); 1.1589 (8.7); 1.1550 (8.3); 1.1493 (8.5); 1.1455 (9.9); 1.1423 (9.6); 1.1369 (5.0); 1.1300 (6.0); 1.1253 (7.2); 1.1203 (4.6); 1.1082 (1.6); 0.8452 (0.6); 0.8402 (0.6); -0.0002 (15.6)
I-707:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1195 (0.7); 9.1051 (1.5); 9.0903 (0.7); 7.9529 (0.7); 7.7378 (0.6); 7.7181 (1.7); 7.6984 (1.6); 7.6781 (2.0); 7.6583 (0.8); 7.5940 (2.3); 7.5504 (1.3); 7.5305 (1.0); 7.1945 (2.5); 7.1472 (0.7); 7.1275 (2.0); 7.1086 (2.8); 7.0892 (1.0); 5.6863 (0.4); 5.6753 (0.6); 5.6695 (0.5); 5.6581 (0.4); 5.5673 (0.4); 5.5560 (0.6); 5.5496 (0.5); 5.5387 (0.5); 3.8449 (0.4); 3.8280 (0.6); 3.8156 (0.7); 3.8013 (0.8); 3.7899 (0.5); 3.7813 (0.6); 3.7657 (0.5); 3.7534 (0.5); 3.7388 (0.5); 3.7274 (0.4); 3.3249 (17.0); 2.8909 (4.7); 2.7320 (4.1); 2.5243 (0.6); 2.5066 (24.8); 2.5022 (32.1); 2.4978 (23.3); 2.2658 (14.2); 2.1844 (16.0); 1.2400 (0.7); 0.0078 (0.3); -0.0002 (8.4)
I-708:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2443 (0.6); 9.2296 (1.4); 9.2148 (0.7); 7.9532 (0.9); 7.7419 (0.6); 7.7223 (1.7); 7.7026 (1.6); 7.6820 (1.8); 7.6624 (0.8); 7.6225 (2.1); 7.5709 (1.2); 7.5512 (0.9); 7.5269 (1.4); 7.5074 (1.8); 7.3961 (2.7); 7.3716 (1.0); 7.1086 (1.0); 6.9688 (2.5); 6.8293 (1.2); 6.0356 (0.4); 6.0283 (0.4); 6.0186 (0.4); 6.0108 (0.4); 5.9191 (0.4); 5.9108 (0.4); 5.9014 (0.4); 5.8929 (0.4); 3.8698 (0.3); 3.8612 (0.4); 3.8558 (0.4); 3.8106 (0.3); 3.8009 (0.4); 3.7931 (0.8); 3.7871 (0.5); 3.7773 (0.6); 3.7557 (0.5); 3.7394 (0.6); 3.7215 (0.4); 3.3250 (19.5); 2.8910 (7.3); 2.7327 (5.9); 2.7315 (6.2); 2.5249 (0.6); 2.5201 (1.0); 2.5115 (13.3); 2.5070 (27.7); 2.5024 (36.7); 2.4978 (26.0); 2.4932 (12.2); 2.4115 (10.0); 2.2472 (16.0); 1.2397 (0.6); 0.0080 (0.5); -0.0002 (14.5); -0.0086 (0.4)
I-709:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1812 (0.7); 9.1665 (1.4); 9.1516 (0.7); 7.9536 (0.9); 7.7451 (0.6); 7.7255 (1.6); 7.7058 (1.5); 7.6846 (1.8); 7.6647 (0.8); 7.5969 (2.2); 7.5576 (1.2); 7.5373 (0.9); 7.4331 (2.2); 7.4133 (2.5); 7.2915 (2.5); 7.1229 (1.4); 7.1032 (1.2); 6.0165 (0.4); 6.0034 (0.9); 5.9904 (0.4); 5.9002 (0.4); 5.8874 (0.9); 5.8739 (0.4); 3.9123 (0.8); 3.8982 (1.4); 3.8842 (0.8); 3.8548 (0.8); 3.8407 (1.4); 3.8268 (0.8); 3.3251 (16.5); 2.8915 (6.7); 2.7325 (5.6); 2.5252 (0.5); 2.5203 (0.8); 2.5117 (11.9); 2.5073 (24.2); 2.5028 (31.7); 2.4983 (22.8); 2.4939 (11.0); 2.2668 (16.0); 2.2595 (9.9); 1.2393 (0.7); -0.0002 (9.2); -0.0082 (0.3)
I-710:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2107 (0.7); 9.1959 (1.4); 9.1811 (0.7); 7.7435 (0.6); 7.7239 (1.7); 7.7042 (1.6); 7.6826 (1.9); 7.6629 (0.8); 7.6057 (2.3); 7.5641 (1.2); 7.5439 (1.0); 7.3968 (2.2); 7.3760 (2.7); 7.2792 (2.2); 7.2301 (1.4); 7.2250 (1.2); 7.2094 (1.1); 7.2042 (1.0); 5.9691 (0.4); 5.9602 (0.5); 5.9518 (0.5); 5.9428 (0.4); 5.8524 (0.4); 5.8433 (0.5); 5.8351 (0.6); 5.8263 (0.4); 3.8461 (0.4); 3.8368 (0.4); 3.8323 (0.4); 3.8228 (0.3); 3.7930 (0.4); 3.7781 (0.8); 3.7699 (0.5); 3.7646 (0.6); 3.7605 (0.6); 3.7571 (0.6); 3.7401 (0.6); 3.7241 (0.7); 3.7070 (0.4); 3.3249 (19.3); 2.8912 (0.4); 2.7316 (0.4); 2.5249 (0.6); 2.5200 (1.0); 2.5115 (13.9); 2.5070 (28.3); 2.5025 (37.0); 2.4979 (26.4); 2.4934 (12.5); 2.3494 (10.8); 2.2774 (16.0); 1.2393 (1.0); 0.0080 (0.4); -0.0002 (11.9); -0.0085 (0.4)
I-711:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1772 (0.7); 9.1626 (1.4); 9.1478 (0.7); 7.9534 (1.1); 7.7452 (0.6); 7.7257 (1.7); 7.7061 (1.6); 7.6857 (1.9); 7.6660 (0.8); 7.6099 (2.2); 7.5609 (1.2); 7.5412 (0.9); 7.4165 (2.4); 7.3963 (2.6); 7.1789 (2.7); 7.0124 (1.4); 7.0084 (1.4); 6.9921 (1.3); 6.9880 (1.3); 5.9994 (0.4); 5.9865 (1.0); 5.9735 (0.4); 5.8836 (0.4); 5.8707 (0.9); 5.8573 (0.4); 3.9035 (0.8); 3.8896 (1.4); 3.8756 (0.8); 3.8460 (0.7); 3.8322 (1.3); 3.8180 (0.8); 3.3249 (21.3); 2.8914 (7.9); 2.7329 (6.7); 2.7319 (6.5); 2.5252 (0.6); 2.5204 (1.0); 2.5117 (13.8); 2.5072 (28.1); 2.5027 (37.0); 2.4981 (26.4); 2.4936 (12.5); 2.2547 (16.0); 1.9235 (0.6); 1.9150 (0.6); 1.9027 (1.2); 1.8902 (0.7); 1.8818 (0.6); 1.8691 (0.3); 1.2394 (0.8); 0.9859 (0.5); 0.9828 (0.5); 0.9749 (2.0); 0.9694 (2.2); 0.9620 (1.0); 0.9586 (0.9); 0.9540 (2.0); 0.9484 (2.1); 0.9412 (0.5); 0.9379 (0.6); 0.6791 (0.9); 0.6665 (2.2); 0.6624 (1.8); 0.6552 (2.0); 0.6503 (1.4); 0.6426 (0.8); 0.0080 (0.4); -0.0002 (11.2); -0.0085 (0.4)
I-712:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2105 (0.7); 9.1958 (1.4); 9.1811 (0.7); 7.7450 (0.6); 7.7254 (1.7); 7.7057 (1.6); 7.6837 (1.8); 7.6641 (0.8); 7.6109 (2.2); 7.5651 (1.2); 7.5449 (0.9); 7.4227 (2.3); 7.3689 (0.7); 7.3644 (0.6); 7.3481 (1.9); 7.3435 (1.8); 7.3251 (3.6); 7.3043 (1.3); 5.9567 (0.4); 5.9482 (0.5); 5.9395 (0.5); 5.9308 (0.4); 5.8400 (0.4); 5.8312 (0.5); 5.8229 (0.6); 5.8139 (0.5); 3.8440 (0.4); 3.8349 (0.4); 3.8300 (0.4); 3.8209 (0.3); 3.7891 (0.4); 3.7725 (0.7); 3.7627 (0.5); 3.7545 (0.6); 3.7349 (0.6); 3.7190 (0.7); 3.7016 (0.4); 3.3262 (19.9); 2.8914 (2.0); 2.7329 (1.7); 2.7317 (1.7); 2.5252 (0.6); 2.5205 (0.8); 2.5118 (11.5); 2.5073 (23.5); 2.5027 (30.8); 2.4981 (22.0); 2.4936 (10.4); 2.3462 (10.8); 2.3297 (0.3); 2.2749 (16.0); 1.2392 (1.0); -0.0002 (7.0)
I-713:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1851 (0.7); 9.1706 (1.5); 9.1560 (0.7); 7.9524 (1.1); 7.2033 (2.4); 7.1689 (0.8); 7.1484 (2.6); 7.1450 (2.6); 7.1362 (3.7); 7.1164 (0.7); 7.0962 (0.9); 7.0919 (1.0); 7.0741 (1.3); 7.0578 (0.6); 7.0538 (0.6); 6.9384 (0.7); 6.9344 (0.7); 6.9186 (1.2); 6.9021 (0.7); 6.8985 (0.6); 5.6872 (0.4); 5.6762 (0.6); 5.6695 (0.5); 5.6585 (0.4); 5.5674 (0.4); 5.5568 (0.6); 5.5492 (0.5); 5.5385 (0.5); 3.8386 (0.4); 3.8208 (0.6); 3.8139 (0.4); 3.8066 (0.7); 3.7936 (0.9); 3.7791 (0.6); 3.7600 (0.5); 3.7428 (0.4); 3.7284 (0.5); 3.7174 (0.4); 3.3240 (16.5); 2.8904 (8.4); 2.7321 (7.0); 2.7309 (6.9); 2.5241 (0.5); 2.5194 (0.9); 2.5108 (12.2); 2.5063 (25.1); 2.5017 (33.0); 2.4971 (23.3); 2.4925 (10.9); 2.2580 (16.0); 2.2383 (0.3); 2.1983 (12.6); 2.1906 (8.4); 2.0930 (0.3); 2.0803 (0.5); 2.0720 (0.6); 2.0594 (1.1); 2.0465 (0.6); 2.0384 (0.6); 1.2397 (0.6); 1.0407 (0.8); 1.0298 (2.1); 1.0243 (2.2); 1.0197 (1.2); 1.0140 (1.2); 1.0086 (2.1); 1.0032 (2.2); 0.9930 (0.8); 0.7926 (0.9); 0.7822 (2.3); 0.7771 (2.4); 0.7696 (2.2); 0.7643 (2.4); 0.7531 (0.7); 0.0081 (0.3); -0.0002 (9.6)
I-714:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2991 (0.8); 9.2843 (1.7); 9.2698 (0.8); 7.9524 (1.6); 7.5463 (1.6); 7.5361 (0.5); 7.5253 (2.2); 7.4082 (3.2); 7.1752 (0.7); 7.1555 (2.1); 7.1362 (2.1); 7.1252 (1.1); 7.1205 (1.4); 7.1078 (1.8); 7.0872 (0.6); 7.0831 (0.6); 6.9706 (2.6); 6.9438 (0.8); 6.9394 (0.9); 6.9246 (1.5); 6.9077 (0.8); 6.9041 (0.8); 6.8309 (1.2); 6.0424 (0.5); 6.0351 (0.5); 6.0250 (0.6); 6.0172 (0.5); 5.9244 (0.5); 5.9168 (0.5); 5.9078 (0.6); 5.8994 (0.5); 3.8562 (0.4); 3.8476 (0.5); 3.8432 (0.5); 3.8341 (0.4); 3.8007 (0.5); 3.7849 (0.9); 3.7732 (0.6); 3.7650 (0.8); 3.7471 (0.6); 3.7307 (0.8); 3.7137 (0.4); 3.3252 (19.6); 2.8905 (10.5); 2.7311 (9.5); 2.5065 (29.8); 2.5021 (40.6); 2.4977 (32.0); 2.4195 (11.9); 2.2508 (16.0); 2.0812 (0.6); 2.0727 (0.7); 2.0604 (1.2); 2.0476 (0.8); 2.0395 (0.7); 2.0261 (0.3); 1.2391 (0.9); 1.0385 (0.8); 1.0273 (2.2); 1.0220 (2.5); 1.0118 (1.3); 1.0063 (2.3); 1.0010 (2.5); 0.9908 (0.9); 0.7930 (0.9); 0.7777 (3.0); 0.7698 (2.6); 0.7649 (2.9); 0.7536 (0.8); 0.0079 (0.3); -0.0002 (9.5); -0.0082 (0.5)
I-715:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1749 (0.6); 9.1605 (1.3); 9.1459 (0.6); 7.9529 (1.5); 7.4088 (2.0); 7.3889 (2.2); 7.2161 (2.2); 7.1670 (0.6); 7.1475 (1.6); 7.1274 (1.2); 7.0881 (0.8); 7.0840 (0.9); 7.0679 (1.1); 7.0660 (1.1); 7.0497 (0.6); 7.0455 (0.6); 7.0369 (1.2); 7.0170 (1.1); 6.9391 (0.7); 6.9351 (0.7); 6.9192 (1.2); 6.9026 (0.6); 6.8990 (0.5); 5.8089 (0.4); 5.7981 (0.5); 5.7925 (0.4); 5.7817 (0.4); 5.6900 (0.4); 5.6791 (0.5); 5.6734 (0.4); 5.6625 (0.4); 3.9194 (0.4); 3.9033 (0.7); 3.8970 (0.5); 3.8873 (0.9); 3.8618 (16.0); 3.8350 (0.6); 3.8202 (0.5); 3.8091 (0.3); 3.3250 (21.8); 2.8911 (11.3); 2.7325 (9.7); 2.7313 (9.3); 2.5246 (0.6); 2.5199 (0.9); 2.5113 (12.0); 2.5068 (24.2); 2.5022 (31.6); 2.4976 (22.2); 2.4931 (10.4); 2.2499 (14.3); 2.0785 (0.5); 2.0703 (0.5); 2.0577 (1.0); 2.0448 (0.6); 2.0368 (0.5); 1.2398 (0.6); 1.0387 (0.7); 1.0277 (1.9); 1.0222 (2.0); 1.0177 (1.0); 1.0119 (1.0); 1.0066 (1.9); 1.0011 (1.9); 0.9909 (0.8); 0.7927 (0.8); 0.7823 (2.1); 0.7773 (2.1); 0.7697 (2.0); 0.7645 (2.1); 0.7533 (0.7); -0.0002 (9.6)
I-716:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1394 (0.7); 9.1249 (1.4); 9.1102 (0.7); 7.9528 (1.4); 7.7084 (2.4); 7.7042 (2.5); 7.6088 (2.1); 7.5881 (2.7); 7.4456 (1.4); 7.4409 (1.4); 7.4246 (1.1); 7.4200 (1.1); 7.1677 (0.7); 7.1480 (1.8); 7.1280 (1.3); 7.0756 (0.9); 7.0716 (1.0); 7.0535 (1.3); 7.0371 (0.6); 7.0333 (0.6); 6.9384 (0.8); 6.9346 (0.8); 6.9186 (1.3); 6.9020 (0.7); 6.8985 (0.6); 5.8764 (0.4); 5.8641 (0.7); 5.8511 (0.4); 5.7596 (0.4); 5.7479 (0.7); 5.7345 (0.5); 3.9642 (0.4); 3.9487 (0.6); 3.9330 (0.4); 3.9273 (0.4); 3.9060 (0.4); 3.8904 (0.8); 3.8860 (0.6); 3.8744 (0.5); 3.8416 (0.4); 3.8356 (0.3); 3.8279 (0.5); 3.8167 (0.4); 3.3248 (21.7); 2.8910 (10.5); 2.7317 (8.9); 2.5248 (0.6); 2.5198 (0.9); 2.5112 (13.8); 2.5068 (28.4); 2.5023 (37.5); 2.4977 (26.9); 2.4932 (12.8); 2.2252 (16.0); 2.0793 (0.5); 2.0711 (0.6); 2.0584 (1.2); 2.0454 (0.7); 2.0374 (0.6); 1.2394 (0.9); 1.0395 (0.7); 1.0285 (2.1); 1.0231 (2.2); 1.0187 (1.2); 1.0128 (1.2); 1.0074 (2.1); 1.0020 (2.2); 0.9919 (0.8); 0.7929 (0.9); 0.7825 (2.4); 0.7775 (2.5); 0.7699 (2.3); 0.7647 (2.5); 0.7535 (0.7); -0.0002 (9.9); -0.0086 (0.3)
I-717:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2425 (0.5); 9.2280 (1.0); 9.2130 (0.5); 7.9528 (1.0); 7.4496 (1.6); 7.4298 (1.8); 7.3059 (1.8); 7.1770 (0.4); 7.1574 (1.3); 7.1483 (1.1); 7.1376 (1.1); 7.1296 (0.9); 7.1092 (0.6); 7.1049 (0.7); 7.0872 (0.9); 7.0709 (0.4); 7.0669 (0.4); 6.9437 (0.5); 6.9397 (0.5); 6.9241 (0.9); 6.9074 (0.5); 6.9035 (0.4); 6.0128 (0.5); 5.8975 (0.4); 3.9054 (0.4); 3.8992 (0.4); 3.8895 (0.8); 3.8741 (0.5); 3.8501 (0.3); 3.8351 (0.7); 3.8236 (0.5); 3.8127 (0.3); 3.3254 (19.1); 2.8908 (7.0); 2.7315 (6.0); 2.5247 (0.4); 2.5112 (8.8); 2.5068 (18.1); 2.5023 (24.0); 2.4977 (17.3); 2.4932 (8.4); 2.2629 (16.0); 2.0851 (0.4); 2.0766 (0.4); 2.0640 (0.7); 2.0513 (0.4); 2.0431 (0.4); 1.2394 (0.5); 1.0438 (0.5); 1.0328 (1.4); 1.0273 (1.5); 1.0229 (0.8); 1.0170 (0.8); 1.0117 (1.4); 1.0063 (1.5); 0.9961 (0.6); 0.7968 (0.6); 0.7865 (1.6); 0.7815 (1.6); 0.7738 (1.5); 0.7687 (1.7); 0.7575 (0.5); -0.0002 (6.4)
I-718:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2661 (0.7); 9.2513 (1.5); 9.2366 (0.7); 7.9529 (1.5); 7.4144 (2.2); 7.3936 (2.8); 7.2927 (2.2); 7.2567 (1.5); 7.2515 (1.2); 7.2359 (1.2); 7.2307 (1.0); 7.1768 (0.6); 7.1574 (1.8); 7.1375 (1.6); 7.1182 (1.0); 7.1137 (1.1); 7.0962 (1.3); 7.0800 (0.6); 7.0760 (0.5); 6.9447 (0.7); 6.9404 (0.7); 6.9251 (1.2); 6.9084 (0.7); 6.9046 (0.6); 5.9768 (0.4); 5.9681 (0.5); 5.9592 (0.6); 5.9503 (0.4); 5.8599 (0.4); 5.8507 (0.5); 5.8425 (0.6); 5.8333 (0.5); 3.8321 (0.4); 3.8229 (0.4); 3.8186 (0.4); 3.8092 (0.3); 3.7873 (0.5); 3.7707 (0.6); 3.7644 (0.5); 3.7540 (0.8); 3.7401 (0.5); 3.7351 (0.6); 3.7182 (0.7); 3.7015 (0.4); 3.3255 (31.2); 2.8910 (11.1); 2.7324 (9.3); 2.7314 (9.1); 2.5246 (0.6); 2.5198 (1.1); 2.5113 (14.9); 2.5068 (30.1); 2.5022 (39.3); 2.4976 (27.8); 2.4931 (13.1); 2.3592 (11.0); 2.2739 (16.0); 2.0830 (0.5); 2.0746 (0.6); 2.0618 (1.1); 2.0490 (0.6); 2.0409 (0.6); 1.2395 (0.8); 1.0399 (0.8); 1.0289 (2.1); 1.0235 (2.2); 1.0189 (1.2); 1.0132 (1.2); 1.0078 (2.1); 1.0024 (2.2); 0.9922 (0.9); 0.7946 (0.9); 0.7843 (2.4); 0.7792 (2.4); 0.7716 (2.3); 0.7664 (2.4); 0.7552 (0.8); 0.0080 (0.4); -0.0002 (11.2); -0.0086 (0.4)
I-719:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2369 (0.8); 9.2225 (1.5); 9.2075 (0.8); 7.9528 (1.6); 7.4300 (2.5); 7.4098 (2.8); 7.1943 (3.0); 7.1790 (0.7); 7.1595 (1.9); 7.1396 (1.6); 7.1167 (0.9); 7.1123 (1.2); 7.0947 (1.3); 7.0784 (0.6); 7.0745 (0.6); 7.0180 (1.5); 7.0140 (1.5); 6.9977 (1.4); 6.9937 (1.4); 6.9454 (0.7); 6.9413 (0.8); 6.9258 (1.3); 6.9090 (0.7); 6.9055 (0.6); 6.0089 (0.5); 5.9975 (0.7); 5.9829 (0.5); 5.8927 (0.4); 5.8823 (0.7); 5.8779 (0.6); 5.8667 (0.5); 3.9017 (0.4); 3.8864 (1.0); 3.8772 (0.8); 3.8712 (0.7); 3.8666 (0.6); 3.8462 (0.5); 3.8300 (1.0); 3.8153 (1.0); 3.8043 (0.4); 3.3264 (39.4); 2.8910 (11.5); 2.7325 (9.5); 2.7315 (9.7); 2.5248 (0.7); 2.5202 (1.0); 2.5114 (13.8); 2.5070 (29.1); 2.5024 (38.9); 2.4978 (28.5); 2.4934 (14.0); 2.2536 (16.0); 2.0855 (0.6); 2.0769 (0.6); 2.0643 (1.1); 2.0515 (0.7); 2.0433 (0.6); 1.9284 (0.6); 1.9200 (0.7); 1.9075 (1.3); 1.8951 (0.8); 1.8868 (0.7); 1.8740 (0.3); 1.2393 (0.8); 1.0435 (0.8); 1.0324 (2.1); 1.0270 (2.3); 1.0226 (1.3); 1.0167 (1.2); 1.0114 (2.2); 1.0059 (2.3); 0.9958 (0.9); 0.9848 (0.5); 0.9721 (2.3); 0.9662 (2.7); 0.9512 (2.4); 0.9453 (2.5); 0.9330 (0.4); 0.7966 (0.9); 0.7862 (2.4); 0.7812 (2.6); 0.7735 (2.4); 0.7684 (2.6); 0.7572 (0.8); 0.6730 (1.4); 0.6668 (1.1); 0.6617 (2.0); 0.6567 (2.0); 0.6441 (1.4); -0.0002 (10.0); -0.0084 (0.4)
I-720:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2636 (0.7); 9.2489 (1.4); 9.2341 (0.7); 7.9529 (1.5); 7.4324 (2.3); 7.3918 (0.8); 7.3873 (0.6); 7.3710 (1.8); 7.3663 (1.7); 7.3422 (3.5); 7.3214 (1.5); 7.1781 (0.6); 7.1583 (1.8); 7.1384 (1.6); 7.1187 (0.9); 7.1141 (1.1); 7.0967 (1.2); 7.0805 (0.6); 7.0764 (0.5); 6.9451 (0.7); 6.9406 (0.7); 6.9257 (1.2); 6.9088 (0.7); 6.9049 (0.6); 5.9645 (0.4); 5.9557 (0.5); 5.9468 (0.5); 5.9380 (0.4); 5.8475 (0.4); 5.8384 (0.5); 5.8302 (0.6); 5.8210 (0.4); 3.8294 (0.3); 3.8203 (0.4); 3.8159 (0.4); 3.8065 (0.3); 3.7845 (0.4); 3.7677 (0.6); 3.7621 (0.5); 3.7514 (0.7); 3.7380 (0.4); 3.7315 (0.6); 3.7149 (0.7); 3.6981 (0.4); 3.3251 (21.8); 2.8909 (11.2); 2.7326 (9.4); 2.7314 (9.4); 2.5248 (0.6); 2.5201 (0.8); 2.5113 (12.4); 2.5068 (25.6); 2.5022 (33.9); 2.4976 (24.2); 2.4931 (11.5); 2.3545 (10.8); 2.2721 (16.0); 2.0841 (0.5); 2.0761 (0.6); 2.0633 (1.1); 2.0504 (0.6); 2.0423 (0.6); 1.2394 (0.8); 1.0405 (0.7); 1.0295 (2.0); 1.0240 (2.2); 1.0195 (1.1); 1.0137 (1.1); 1.0084 (2.1); 1.0029 (2.2); 0.9928 (0.9); 0.7958 (0.9); 0.7854 (2.3); 0.7803 (2.4); 0.7727 (2.2); 0.7676 (2.4); 0.7564 (0.8); -0.0002 (10.0); -0.0085 (0.3)
I-721:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2486 (13.7); 7.9807 (1.1); 7.9703 (1.8); 7.9599 (1.2); 7.5458 (6.1); 7.3683 (0.3); 7.3524 (16.0); 7.3335 (0.5); 7.2600 (16.2); 7.1530 (1.1); 7.1365 (3.8); 7.1272 (2.7); 7.1223 (8.0); 7.1143 (2.6); 7.1106 (3.1); 7.0982 (1.0); 7.0943 (0.8); 6.8853 (1.4); 6.8794 (1.4); 6.8720 (2.6); 6.8674 (2.4); 6.8567 (1.5); 6.8532 (1.4); 6.0575 (1.3); 6.0510 (1.5); 6.0445 (1.5); 6.0379 (1.4); 5.9649 (1.3); 5.9584 (1.5); 5.9518 (1.5); 5.9452 (1.4); 5.2982 (2.2); 4.2621 (0.6); 4.2555 (0.7); 4.2491 (0.7); 4.2425 (0.7); 4.2327 (0.8); 4.2261 (0.8); 4.2198 (0.8); 4.2124 (1.2); 4.2051 (0.7); 4.1987 (0.8); 4.1920 (0.7); 4.1823 (0.8); 4.1757 (0.8); 4.1693 (0.8); 4.1627 (0.8); 3.8934 (0.7); 3.8809 (1.0); 3.8695 (0.8); 3.8641 (0.7); 3.8510 (1.0); 3.8478 (1.0); 3.8398 (0.8); 3.8365 (1.1); 3.8237 (0.8); 3.8183 (0.7); 3.8057 (0.8); 3.7944 (0.6); 2.1396 (0.5); 2.1292 (1.2); 2.1225 (1.3); 2.1123 (2.4); 2.1020 (1.4); 2.0954 (1.3); 2.0850 (0.7); 1.5493 (7.4); 1.2554 (0.7); 1.0671 (1.5); 1.0578 (4.4); 1.0541 (4.8); 1.0451 (2.5); 1.0409 (4.7); 1.0371 (4.7); 1.0282 (2.0); 0.8080 (1.9); 0.7986 (5.3); 0.7956 (5.3); 0.7886 (4.9); 0.7854 (5.8); 0.7758 (1.8); 0.0062 (0.7); -0.0002 (18.5)
I-722:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2482 (13.2); 7.9705 (1.8); 7.9601 (1.1); 7.5472 (5.7); 7.5456 (6.0); 7.3681 (0.3); 7.3524 (16.0); 7.2600 (15.1); 7.1527 (1.1); 7.1362 (3.8); 7.1269 (3.1); 7.1220 (7.8); 7.1141 (2.6); 7.1103 (2.9); 7.0979 (1.0); 7.0940 (0.7); 6.8850 (1.4); 6.8791 (1.5); 6.8717 (2.7); 6.8673 (2.2); 6.8565 (1.5); 6.8529 (1.3); 6.0574 (1.3); 6.0508 (1.5); 6.0443 (1.5); 6.0377 (1.3); 5.9647 (1.3); 5.9582 (1.5); 5.9516 (1.5); 5.9451 (1.3); 4.2617 (0.6); 4.2551 (0.7); 4.2487 (0.7); 4.2421 (0.7); 4.2324 (0.8); 4.2257 (0.8); 4.2193 (0.8); 4.2120 (1.2); 4.2047 (0.7); 4.1983 (0.7); 4.1917 (0.7); 4.1819 (0.8); 4.1753 (0.8); 4.1689 (0.8); 4.1623 (0.7); 3.8933 (0.7); 3.8825 (1.0); 3.8805 (1.0); 3.8695 (0.8); 3.8640 (0.7); 3.8529 (0.9); 3.8510 (1.0); 3.8477 (1.0); 3.8400 (0.9); 3.8368 (1.1); 3.8236 (0.8); 3.8182 (0.7); 3.8073 (0.8); 3.8053 (0.8); 3.7944 (0.6); 2.1393 (0.5); 2.1289 (1.2); 2.1223 (1.3); 2.1120 (2.3); 2.1017 (1.4); 2.0951 (1.2); 2.0847 (0.6); 1.5510 (5.4); 1.4319 (0.4); 1.2558 (0.6); 1.0669 (1.6); 1.0576 (4.6); 1.0539 (4.6); 1.0503 (2.5); 1.0449 (2.6); 1.0406 (4.7); 1.0369 (4.4); 1.0280 (1.8); 0.8078 (2.0); 0.7986 (5.4); 0.7953 (5.1); 0.7885 (5.0); 0.7852 (5.4); 0.7756 (1.6); -0.0002 (18.0); -0.0067 (0.8)
I-723:1 H-NMR(499.9 MHz, CDCl3): δ= 7.4038 (1.9); 7.3868 (3.6); 7.3809 (1.8); 7.3123 (1.2); 7.2959 (2.4); 7.2794 (1.4); 7.2607 (3.8); 7.1846 (1.3); 7.1805 (1.3); 7.1678 (1.2); 7.1638 (1.2); 6.8158 (0.5); 6.8053 (1.8); 6.8017 (1.8); 6.7890 (1.3); 6.7848 (1.2); 6.7529 (1.0); 6.7495 (1.2); 6.7367 (0.9); 6.7334 (1.2); 6.7096 (1.5); 6.7051 (2.4); 6.7006 (1.2); 5.9849 (0.4); 5.9788 (0.5); 5.9714 (0.5); 5.9653 (0.4); 5.8920 (0.4); 5.8858 (0.5); 5.8785 (0.5); 5.8723 (0.4); 5.2970 (0.7); 3.8596 (0.4); 3.8290 (0.4); 3.8149 (0.5); 3.8014 (0.3); 3.7814 (16.0); 2.3418 (13.6); 1.9977 (4.2); 1.2555 (0.4); 1.2093 (0.5); 1.1970 (0.5); -0.0002 (4.2)
I-724:1 H-NMR(499.9 MHz, CDCl3): δ= 7.4045 (2.0); 7.3873 (3.9); 7.3127 (1.3); 7.2962 (2.5); 7.2798 (1.4); 7.2608 (4.1); 7.1850 (1.5); 7.1811 (1.4); 7.1683 (1.2); 7.1643 (1.2); 6.8055 (1.8); 6.8011 (2.3); 6.7890 (1.6); 6.7855 (1.4); 6.7534 (1.2); 6.7500 (1.3); 6.7372 (1.1); 6.7340 (1.2); 6.7104 (1.8); 6.7059 (2.6); 6.7014 (1.2); 5.9859 (0.5); 5.9798 (0.6); 5.9725 (0.6); 5.9663 (0.5); 5.8930 (0.5); 5.8868 (0.6); 5.8795 (0.6); 5.8734 (0.5); 4.0918 (0.3); 4.0855 (0.4); 4.0790 (0.4); 4.0726 (0.4); 4.0693 (0.3); 4.0396 (0.3); 4.0332 (0.3); 4.0268 (0.3); 3.8607 (0.5); 3.8479 (0.4); 3.8443 (0.3); 3.8306 (0.5); 3.8161 (0.6); 3.8024 (0.5); 3.7987 (0.6); 3.7817 (16.0); 2.5976 (0.4); 2.3433 (13.6); 1.9980 (6.4); 1.2555 (0.4); -0.0002 (4.6)
I-725:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5515 (3.2); 7.3779 (0.6); 7.3749 (0.5); 7.3611 (3.2); 7.3580 (3.6); 7.3535 (5.1); 7.3355 (1.5); 7.3186 (2.6); 7.3026 (1.8); 7.2611 (7.2); 7.2152 (1.5); 7.2134 (1.8); 7.2118 (1.9); 7.1979 (4.1); 7.1955 (3.9); 7.0810 (1.5); 7.0781 (1.4); 7.0766 (1.4); 7.0661 (1.1); 7.0638 (1.3); 7.0624 (1.4); 7.0602 (1.2); 6.5094 (0.6); 6.4975 (1.1); 6.4857 (0.7); 5.9981 (0.6); 5.9919 (0.7); 5.9841 (0.7); 5.9779 (0.7); 5.9048 (0.6); 5.8986 (0.7); 5.8907 (0.7); 5.8846 (0.7); 4.1868 (0.3); 4.1806 (0.4); 4.1735 (0.4); 4.1673 (0.4); 4.1574 (0.4); 4.1511 (0.4); 4.1441 (0.4); 4.1378 (0.4); 4.1329 (0.4); 4.1265 (0.4); 4.1195 (0.4); 4.1132 (0.4); 4.1033 (0.4); 4.0971 (0.4); 4.0901 (0.4); 4.0838 (0.4); 3.8628 (0.4); 3.8492 (0.5); 3.8372 (0.4); 3.8336 (0.4); 3.8193 (0.8); 3.8076 (0.8); 3.7934 (0.4); 3.7897 (0.4); 3.7760 (0.4); 3.7640 (0.3); 2.6249 (0.5); 2.5910 (15.2); 2.2777 (16.0); 2.2573 (0.4); 2.1648 (0.3); 2.0013 (5.8); 1.5814 (1.0); -0.0002 (7.8); -0.0065 (0.5)
I-726:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5519 (3.6); 7.3783 (0.7); 7.3751 (0.6); 7.3615 (3.6); 7.3583 (4.3); 7.3539 (5.8); 7.3362 (1.8); 7.3193 (2.8); 7.3033 (1.9); 7.2611 (9.8); 7.2174 (1.2); 7.2158 (1.6); 7.2138 (2.1); 7.2121 (2.1); 7.1987 (4.9); 7.1961 (4.8); 7.1920 (2.2); 7.0834 (1.4); 7.0818 (1.6); 7.0790 (1.6); 7.0774 (1.6); 7.0671 (1.3); 7.0645 (1.6); 7.0634 (1.5); 7.0608 (1.4); 6.5007 (0.7); 6.4893 (1.2); 6.4778 (0.7); 5.9986 (0.7); 5.9924 (0.8); 5.9845 (0.8); 5.9784 (0.8); 5.9052 (0.7); 5.8991 (0.8); 5.8912 (0.8); 5.8850 (0.8); 4.1878 (0.3); 4.1815 (0.4); 4.1745 (0.4); 4.1683 (0.4); 4.1584 (0.4); 4.1521 (0.5); 4.1451 (0.5); 4.1389 (0.5); 4.1338 (0.4); 4.1275 (0.4); 4.1205 (0.4); 4.1142 (0.4); 4.1043 (0.5); 4.0981 (0.5); 4.0911 (0.5); 4.0848 (0.4); 3.8634 (0.4); 3.8518 (0.5); 3.8496 (0.5); 3.8379 (0.5); 3.8342 (0.4); 3.8198 (0.8); 3.8083 (0.8); 3.7940 (0.5); 3.7903 (0.5); 3.7786 (0.4); 3.7763 (0.5); 3.7647 (0.3); 2.5924 (15.7); 2.2786 (16.0); 2.0015 (10.8); 1.5789 (1.7); 1.2549 (0.3); 0.0063 (0.3); -0.0002 (10.9); -0.0066 (0.8)
I-727:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1926 (1.9); 7.9731 (5.0); 7.9678 (12.0); 7.9559 (4.9); 7.8883 (4.0); 7.8841 (4.2); 7.7998 (5.6); 7.7890 (6.1); 7.5152 (4.3); 7.5043 (4.0); 7.3316 (3.6); 7.3156 (4.0); 7.2724 (3.2); 7.2681 (3.2); 7.2552 (3.0); 7.2508 (3.2); 7.0737 (4.2); 6.9397 (2.2); 6.9238 (2.1); 4.1243 (1.0); 4.1168 (1.0); 4.0955 (2.0); 4.0872 (1.9); 4.0658 (1.0); 4.0578 (1.0); 3.3269 (60.9); 2.5113 (2.0); 2.5078 (4.1); 2.5043 (5.6); 2.5007 (4.2); 2.4975 (2.1); 2.4209 (11.3); 2.2010 (16.0); 2.0762 (1.6)
I-728:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.1751 (1.2); 9.1627 (2.6); 9.1502 (1.3); 8.1851 (3.8); 8.1800 (4.0); 7.9723 (13.8); 7.5178 (3.6); 7.5152 (3.3); 7.5129 (3.7); 7.3284 (3.7); 7.3125 (4.1); 7.0847 (4.1); 6.9678 (2.2); 6.9520 (2.0); 4.1196 (1.2); 4.1071 (1.2); 4.0900 (2.8); 4.0774 (2.7); 4.0601 (1.4); 4.0476 (1.3); 3.3198 (6.9); 2.9673 (2.6); 2.9524 (5.1); 2.9442 (4.0); 2.9377 (3.5); 2.9290 (6.0); 2.9136 (3.4); 2.5118 (1.7); 2.5083 (3.5); 2.5046 (4.9); 2.5010 (3.6); 2.4975 (1.8); 2.4215 (11.2); 2.2348 (16.0); 2.1708 (1.1); 2.1642 (0.5); 2.1555 (3.3); 2.1404 (4.5); 2.1320 (0.8); 2.1254 (3.2); 2.1102 (0.9)
I-729:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2648 (16.0); 7.8331 (2.4); 7.5532 (7.7); 7.3933 (2.4); 7.3901 (2.3); 7.3766 (6.7); 7.3733 (6.7); 7.3594 (9.7); 7.3427 (3.2); 7.2607 (11.6); 7.2447 (0.5); 7.2275 (4.8); 7.2154 (6.3); 7.2020 (6.0); 7.1944 (2.2); 7.1820 (0.6); 7.1774 (0.4); 7.1533 (1.6); 7.1502 (1.8); 7.1416 (3.2); 7.1377 (3.0); 7.1319 (2.0); 7.1237 (1.5); 7.1182 (0.9); 6.0517 (1.7); 6.0454 (1.8); 6.0381 (1.8); 6.0318 (1.6); 5.9588 (1.7); 5.9524 (1.8); 5.9451 (1.8); 5.9388 (1.6); 4.2702 (0.9); 4.2637 (0.9); 4.2570 (1.0); 4.2505 (0.9); 4.2408 (1.1); 4.2344 (1.1); 4.2276 (1.1); 4.2210 (1.2); 4.2182 (1.2); 4.2114 (1.0); 4.2046 (1.0); 4.1982 (0.9); 4.1885 (1.1); 4.1820 (1.1); 4.1753 (1.1); 4.1688 (0.9); 3.8814 (1.0); 3.8707 (1.2); 3.8681 (1.2); 3.8571 (1.1); 3.8521 (1.0); 3.8378 (1.8); 3.8270 (1.8); 3.8129 (1.1); 3.8080 (1.0); 3.7971 (1.0); 3.7945 (1.0); 3.7836 (0.8); 2.9543 (1.6); 2.8802 (1.5); 1.5576 (3.2); 1.4319 (0.4); 1.2561 (0.4); -0.0002 (13.2)
I-730:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2653 (16.0); 7.8328 (2.1); 7.5533 (7.1); 7.3935 (2.2); 7.3901 (1.9); 7.3768 (6.3); 7.3734 (5.9); 7.3596 (9.1); 7.3429 (3.0); 7.2606 (12.7); 7.2451 (0.4); 7.2278 (4.3); 7.2159 (5.5); 7.2024 (5.6); 7.1946 (2.0); 7.1822 (0.5); 7.1536 (1.4); 7.1503 (1.5); 7.1418 (2.9); 7.1378 (2.6); 7.1320 (1.7); 7.1256 (1.3); 7.1237 (1.4); 7.1181 (0.8); 6.0520 (1.5); 6.0456 (1.6); 6.0383 (1.6); 6.0320 (1.4); 5.9590 (1.5); 5.9526 (1.6); 5.9453 (1.6); 5.9390 (1.4); 4.2706 (0.8); 4.2641 (0.8); 4.2574 (0.8); 4.2509 (0.8); 4.2413 (1.0); 4.2348 (1.0); 4.2280 (1.0); 4.2214 (1.1); 4.2184 (1.0); 4.2118 (0.9); 4.2050 (0.9); 4.1986 (0.8); 4.1889 (1.0); 4.1824 (1.0); 4.1757 (1.0); 4.1692 (0.9); 3.8815 (0.9); 3.8708 (1.1); 3.8679 (1.0); 3.8571 (1.0); 3.8522 (0.9); 3.8412 (1.1); 3.8378 (1.6); 3.8270 (1.7); 3.8240 (1.1); 3.8129 (1.0); 3.8079 (0.9); 3.7972 (1.0); 3.7943 (0.9); 3.7836 (0.7); 2.9545 (0.7); 2.8806 (0.7); 2.0041 (0.5); 1.5554 (2.1); 1.2558 (0.3); -0.0002 (14.6); -0.0066 (0.7)
I-731:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2345 (11.7); 8.1802 (0.7); 7.9836 (0.9); 7.9733 (1.4); 7.3692 (0.3); 7.3532 (0.4); 7.3378 (3.5); 7.3219 (3.8); 7.2587 (10.3); 7.2155 (0.7); 7.2078 (1.1); 7.2039 (1.4); 7.1969 (1.8); 7.1886 (1.8); 7.1838 (1.8); 7.1799 (2.0); 7.1641 (6.3); 7.1604 (3.0); 7.1524 (4.3); 7.1495 (3.1); 7.1435 (1.8); 7.1326 (0.6); 7.1278 (0.4); 7.0470 (0.4); 7.0247 (4.0); 6.9367 (2.1); 6.9208 (1.9); 4.2397 (1.7); 4.2277 (1.7); 4.2112 (3.8); 4.1992 (3.6); 4.1826 (1.9); 4.1707 (1.8); 4.1279 (0.4); 4.1135 (0.4); 2.7559 (1.4); 2.7409 (4.2); 2.7257 (4.3); 2.7105 (1.5); 2.4961 (0.4); 2.4738 (11.8); 2.3448 (0.6); 2.3239 (1.1); 2.2706 (16.0); 2.0433 (1.6); 1.5585 (9.2); 1.4351 (0.9); 1.2909 (7.6); 1.2758 (15.3); 1.2605 (7.5); 1.2440 (0.7); 0.0061 (0.8); -0.0002 (11.4); -0.0067 (0.4)
I-732:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2188 (0.8); 8.2083 (1.3); 8.1979 (0.8); 8.1716 (12.0); 8.1032 (0.3); 7.6105 (2.6); 7.5954 (2.8); 7.3737 (4.9); 7.3657 (7.1); 7.2836 (1.2); 7.2760 (1.7); 7.2680 (1.6); 7.2579 (8.4); 7.2514 (1.0); 7.1632 (3.2); 7.1473 (3.7); 7.0131 (3.7); 6.9504 (2.0); 6.9346 (1.8); 6.9107 (1.8); 6.9042 (2.0); 6.8974 (2.0); 6.8909 (1.9); 5.2955 (10.2); 4.0696 (0.8); 4.0576 (1.4); 4.0451 (1.0); 4.0371 (1.3); 4.0305 (1.7); 4.0253 (1.8); 4.0187 (1.3); 4.0101 (1.1); 3.9981 (1.5); 3.9864 (0.8); 3.2461 (0.6); 3.2308 (0.9); 3.2146 (1.2); 3.1984 (1.2); 3.1841 (0.9); 3.0448 (0.8); 3.0362 (0.9); 3.0276 (1.1); 3.0190 (1.0); 3.0126 (0.7); 3.0039 (0.7); 2.9952 (0.8); 2.9866 (0.8); 2.8180 (0.6); 2.8048 (1.2); 2.8008 (0.7); 2.7912 (0.8); 2.7878 (1.4); 2.7759 (1.6); 2.7722 (0.9); 2.7627 (0.8); 2.7587 (1.2); 2.7455 (0.5); 2.3893 (10.7); 2.3530 (0.7); 2.3460 (0.9); 2.3446 (1.0); 2.3370 (1.2); 2.3299 (1.3); 2.3242 (1.0); 2.3213 (1.0); 2.3080 (16.0); 2.2926 (0.7); 1.5674 (6.6); -0.0002 (9.4); -0.0067 (0.5)
I-733:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2515 (16.0); 8.0873 (1.3); 8.0769 (1.9); 7.4022 (5.8); 7.3951 (4.7); 7.3916 (6.3); 7.3888 (5.6); 7.3857 (6.8); 7.3729 (3.4); 7.3570 (6.6); 7.3412 (3.7); 7.2596 (19.1); 7.1896 (3.9); 7.1857 (3.7); 7.1728 (3.2); 7.1688 (3.1); 7.0526 (3.7); 7.0369 (3.3); 6.9739 (3.0); 6.9707 (3.0); 6.9692 (3.1); 6.9578 (2.6); 6.9545 (2.7); 6.9530 (2.8); 6.9044 (4.1); 6.9005 (5.6); 6.8968 (3.4); 6.0577 (1.3); 6.0513 (1.4); 6.0440 (1.4); 6.0375 (1.3); 5.9648 (1.3); 5.9584 (1.4); 5.9511 (1.4); 5.9446 (1.2); 5.2978 (6.1); 4.2593 (0.8); 4.2527 (0.8); 4.2461 (0.9); 4.2395 (0.8); 4.2300 (1.0); 4.2234 (1.0); 4.2168 (1.0); 4.2101 (1.0); 4.2070 (1.0); 4.2003 (0.8); 4.1937 (0.9); 4.1870 (0.8); 4.1775 (0.9); 4.1709 (0.9); 4.1643 (0.9); 4.1577 (0.8); 3.8380 (0.9); 3.8276 (1.0); 3.8244 (1.0); 3.8138 (0.9); 3.8087 (0.9); 3.7981 (1.0); 3.7946 (1.6); 3.7842 (1.6); 3.7809 (1.0); 3.7701 (0.9); 3.7650 (0.8); 3.7546 (0.8); 3.7513 (0.8); 3.7408 (0.6); 2.9550 (0.8); 2.8827 (0.8); 1.9696 (0.8); 1.9594 (1.6); 1.9527 (1.7); 1.9427 (2.9); 1.9327 (1.7); 1.9259 (1.5); 1.9157 (0.8); 1.5528 (2.7); 1.2552 (0.4); 1.0487 (0.4); 1.0369 (2.3); 1.0273 (5.4); 1.0238 (5.4); 1.0204 (3.2); 1.0145 (2.9); 1.0105 (5.4); 1.0069 (4.8); 0.9978 (2.1); 0.7833 (0.4); 0.7728 (0.4); 0.7533 (2.6); 0.7437 (6.7); 0.7405 (5.8); 0.7340 (5.4); 0.7306 (6.5); 0.7209 (1.8); 0.0062 (1.4); -0.0002 (22.0); -0.0067 (0.9)
I-734:1 H-NMR(499.9 MHz, CDCl3): δ= 8.1135 (5.1); 7.8640 (0.8); 7.6027 (1.0); 7.5992 (1.2); 7.5829 (1.8); 7.5759 (1.2); 7.5686 (1.0); 7.5461 (2.7); 7.3932 (0.8); 7.3899 (0.8); 7.3824 (1.3); 7.3766 (3.0); 7.3733 (3.3); 7.3668 (5.4); 7.3502 (1.4); 7.2605 (11.0); 6.0588 (0.6); 6.0523 (0.6); 6.0452 (0.6); 6.0387 (0.6); 5.9658 (0.6); 5.9593 (0.6); 5.9522 (0.6); 5.9457 (0.6); 5.2988 (2.2); 4.2720 (0.3); 4.2655 (0.4); 4.2589 (0.4); 4.2523 (0.4); 4.2427 (0.4); 4.2362 (0.4); 4.2296 (0.4); 4.2228 (0.4); 4.2200 (0.4); 4.2133 (0.3); 4.2067 (0.4); 4.2001 (0.3); 4.1905 (0.4); 4.1840 (0.4); 4.1774 (0.4); 4.1708 (0.3); 3.8858 (0.4); 3.8751 (0.4); 3.8723 (0.5); 3.8615 (0.4); 3.8566 (0.4); 3.8457 (0.4); 3.8421 (0.6); 3.8313 (0.6); 3.8283 (0.5); 3.8173 (0.4); 3.8124 (0.4); 3.8016 (0.4); 3.7988 (0.4); 2.9553 (0.8); 2.8828 (0.8); 2.7280 (16.0); 1.5518 (5.1); 0.0062 (0.8); -0.0002 (13.3); -0.0064 (1.0)
I-735:1 H-NMR(499.9 MHz, CDCl3): δ= 8.1135 (5.2); 7.8750 (0.5); 7.8645 (0.7); 7.8541 (0.4); 7.6027 (0.9); 7.5993 (1.0); 7.5899 (1.3); 7.5861 (1.5); 7.5828 (1.5); 7.5754 (0.9); 7.5686 (0.9); 7.5459 (2.5); 7.3931 (0.8); 7.3898 (0.8); 7.3824 (1.2); 7.3764 (2.8); 7.3731 (3.0); 7.3667 (5.0); 7.3501 (1.3); 7.2606 (9.1); 6.0588 (0.6); 6.0523 (0.6); 6.0452 (0.6); 6.0387 (0.5); 5.9658 (0.6); 5.9593 (0.6); 5.9521 (0.6); 5.9456 (0.5); 5.2986 (10.5); 4.2718 (0.3); 4.2652 (0.3); 4.2586 (0.3); 4.2520 (0.3); 4.2425 (0.4); 4.2359 (0.4); 4.2293 (0.4); 4.2226 (0.4); 4.2198 (0.4); 4.2064 (0.3); 4.1903 (0.4); 4.1837 (0.3); 4.1771 (0.3); 3.8860 (0.4); 3.8752 (0.4); 3.8725 (0.4); 3.8616 (0.4); 3.8567 (0.3); 3.8458 (0.4); 3.8423 (0.6); 3.8314 (0.6); 3.8284 (0.4); 3.8175 (0.4); 3.8125 (0.3); 3.8018 (0.3); 2.7279 (16.0); 1.5625 (0.5); 0.0063 (0.6); -0.0002 (11.0); -0.0068 (0.4)
I-736:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2513 (16.0); 8.0874 (1.2); 8.0771 (1.8); 7.4024 (5.6); 7.3952 (4.6); 7.3917 (5.9); 7.3887 (5.4); 7.3858 (6.8); 7.3729 (3.4); 7.3570 (6.6); 7.3412 (3.9); 7.2597 (18.6); 7.1897 (3.9); 7.1857 (3.8); 7.1729 (3.3); 7.1689 (3.2); 7.0525 (3.6); 7.0369 (3.2); 6.9754 (2.6); 6.9739 (2.7); 6.9707 (3.0); 6.9691 (2.9); 6.9593 (2.4); 6.9577 (2.4); 6.9545 (2.8); 6.9529 (2.6); 6.9046 (4.1); 6.9007 (5.5); 6.8967 (3.4); 6.0579 (1.3); 6.0514 (1.4); 6.0442 (1.4); 6.0377 (1.3); 5.9650 (1.3); 5.9585 (1.4); 5.9512 (1.4); 5.9447 (1.2); 5.2977 (3.9); 4.2592 (0.8); 4.2526 (0.8); 4.2460 (0.8); 4.2394 (0.8); 4.2299 (0.9); 4.2233 (0.9); 4.2167 (0.9); 4.2100 (1.0); 4.2069 (1.0); 4.2002 (0.8); 4.1935 (0.8); 4.1870 (0.8); 4.1774 (0.9); 4.1708 (0.9); 4.1642 (0.9); 4.1576 (0.8); 3.8380 (0.9); 3.8277 (1.0); 3.8243 (1.0); 3.8139 (1.0); 3.8087 (0.9); 3.7983 (0.9); 3.7946 (1.7); 3.7842 (1.7); 3.7807 (1.0); 3.7702 (0.9); 3.7650 (0.9); 3.7547 (0.8); 3.7512 (0.8); 3.7409 (0.7); 2.9546 (0.8); 2.8823 (0.7); 1.9696 (0.8); 1.9595 (1.5); 1.9527 (1.6); 1.9498 (1.1); 1.9427 (2.9); 1.9357 (1.1); 1.9327 (1.7); 1.9259 (1.6); 1.9158 (0.8); 1.5525 (4.3); 1.2552 (0.4); 1.0368 (2.1); 1.0273 (5.0); 1.0237 (5.3); 1.0203 (3.0); 1.0145 (2.9); 1.0105 (5.3); 1.0069 (5.0); 0.9977 (2.3); 0.9845 (0.4); 0.7729 (0.3); 0.7533 (2.4); 0.7437 (6.5); 0.7405 (5.7); 0.7340 (5.4); 0.7306 (6.8); 0.7208 (2.1); 0.0700 (1.2); 0.0063 (1.0); -0.0002 (22.6); -0.0068 (1.1)
I-737:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3695 (1.0); 9.3551 (1.9); 9.3408 (0.9); 7.9614 (1.9); 7.3434 (2.3); 7.3233 (2.5); 7.2770 (7.8); 7.1002 (3.6); 6.9819 (2.0); 6.9624 (1.8); 4.1731 (0.9); 4.1585 (1.0); 4.1368 (1.9); 4.1212 (1.8); 4.0991 (1.0); 4.0848 (0.9); 3.3142 (66.7); 3.1281 (0.6); 3.0986 (1.2); 3.0769 (1.2); 3.0472 (0.6); 2.8997 (8.5); 2.7406 (8.1); 2.5105 (17.6); 2.4455 (9.5); 2.4132 (0.6); 2.2674 (0.6); 2.2231 (16.0); 2.1891 (0.3); 2.1274 (0.6); 2.1142 (0.7); 2.0976 (1.2); 2.0816 (1.5); 2.0698 (1.4); 2.0546 (1.5); 2.0343 (0.9); 1.3613 (0.6); 1.3454 (0.5)
I-738:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2187 (2.2); 7.9612 (2.6); 7.6528 (3.0); 7.5666 (2.6); 7.5459 (3.2); 7.4062 (1.6); 7.3819 (2.2); 7.3583 (1.2); 7.2825 (8.6); 6.0587 (1.3); 5.9441 (1.3); 3.9967 (0.3); 3.9368 (1.5); 3.8883 (1.4); 3.3132 (83.3); 3.1306 (0.7); 3.1020 (1.4); 3.0791 (1.5); 3.0486 (0.7); 2.8997 (11.8); 2.7407 (11.2); 2.5106 (23.1); 2.4126 (0.6); 2.4010 (0.6); 2.2715 (16.0); 2.1480 (0.3); 2.1007 (1.5); 2.0819 (1.8); 2.0682 (1.6); 2.0547 (1.9); 2.0335 (1.1); 1.4004 (0.6); 1.3838 (0.6); 1.3613 (0.6); 1.3446 (0.6)
I-739:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4171 (2.5); 7.4101 (2.7); 7.3099 (2.1); 7.2991 (2.3); 7.2825 (2.8); 7.2168 (0.5); 7.1264 (1.8); 7.1193 (2.1); 7.0990 (1.6); 7.0914 (3.1); 7.0806 (1.6); 7.0689 (3.8); 7.0595 (1.2); 7.0524 (1.4); 7.0324 (0.4); 6.8467 (0.7); 6.8353 (0.7); 6.8254 (1.2); 6.8169 (1.1); 6.8002 (0.7); 6.7933 (0.6); 4.1853 (0.4); 4.1628 (0.9); 4.1370 (2.0); 4.1102 (2.4); 4.0860 (1.1); 4.0617 (0.4); 4.0073 (1.4); 3.6028 (16.0); 3.2442 (1.8); 3.2204 (3.6); 3.1952 (1.7); 2.3522 (15.6); 2.1375 (0.6); 2.1266 (0.6); 2.1094 (1.1); 2.0923 (0.6); 2.0813 (0.7); 2.0396 (1.3); 1.6435 (1.2); 1.3003 (0.9); 1.0575 (0.7); 1.0438 (1.8); 1.0373 (2.0); 1.0236 (1.1); 1.0155 (1.9); 1.0088 (1.8); 0.9954 (0.7); 0.9387 (0.3); 0.9169 (0.9); 0.8935 (0.4); 0.8076 (1.0); 0.7906 (2.2); 0.7863 (2.0); 0.7745 (2.2); 0.7691 (1.6); 0.7568 (0.7); 0.0358 (2.7)
I-740:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3970 (3.8); 7.3906 (4.5); 7.3751 (5.6); 7.2985 (1.7); 7.2706 (2.4); 7.2435 (3.6); 7.1226 (1.0); 7.0964 (5.0); 7.0707 (6.4); 7.0430 (1.9); 7.0209 (0.6); 6.8521 (1.4); 6.8437 (1.1); 6.8297 (2.5); 6.8230 (2.0); 6.8048 (1.2); 6.7989 (1.2); 6.3406 (0.5); 5.3226 (1.6); 4.1302 (2.2); 4.1069 (4.3); 4.0833 (2.4); 3.9689 (1.7); 3.8635 (0.5); 3.8576 (0.5); 3.6161 (16.0); 3.2059 (2.3); 3.1986 (1.4); 3.1824 (4.1); 3.1591 (2.2); 3.0985 (0.6); 2.1575 (0.4); 2.1404 (0.9); 2.1292 (1.1); 2.1123 (1.9); 2.0954 (1.1); 2.0842 (1.0); 2.0668 (0.5); 1.2893 (1.5); 1.0625 (1.2); 1.0466 (3.1); 1.0409 (3.2); 1.0187 (3.0); 1.0133 (2.8); 0.9982 (1.0); 0.9332 (0.4); 0.9117 (1.2); 0.8886 (0.5); 0.8103 (1.7); 0.7950 (4.7); 0.7903 (4.6); 0.7784 (4.0); 0.7729 (4.8); 0.7563 (1.3); 0.0320 (1.5)
I-741:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5276 (0.5); 7.5121 (1.7); 7.4964 (2.1); 7.4896 (2.4); 7.4739 (0.7); 7.4415 (2.3); 7.4197 (2.4); 7.4030 (2.9); 7.3945 (2.0); 7.3913 (2.7); 7.3886 (2.1); 7.3724 (1.4); 7.3571 (1.1); 7.2627 (2.8); 7.2208 (1.8); 7.2168 (1.7); 7.2040 (1.5); 7.2000 (1.4); 6.6699 (0.6); 6.6580 (1.0); 6.6460 (0.6); 6.0104 (0.6); 6.0044 (0.6); 5.9961 (0.6); 5.9900 (0.6); 5.9170 (0.6); 5.9109 (0.6); 5.9026 (0.6); 5.8965 (0.6); 5.2959 (1.5); 4.1796 (0.3); 4.1734 (0.3); 4.1664 (0.3); 4.1602 (0.3); 4.1502 (0.4); 4.1440 (0.4); 4.1370 (0.4); 4.1308 (0.4); 4.1246 (0.4); 4.1113 (0.3); 4.1051 (0.3); 4.0951 (0.4); 4.0889 (0.4); 4.0819 (0.4); 4.0757 (0.4); 3.8500 (0.4); 3.8383 (0.4); 3.8357 (0.4); 3.8240 (0.4); 3.8207 (0.4); 3.8069 (0.7); 3.7951 (0.7); 3.7811 (0.4); 3.7779 (0.4); 3.7661 (0.4); 3.7635 (0.4); 2.5682 (15.8); 2.2644 (16.0); -0.0002 (3.2)
I-742:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5292 (0.6); 7.5137 (1.8); 7.4981 (2.2); 7.4906 (2.6); 7.4750 (0.9); 7.4437 (2.4); 7.4211 (2.5); 7.4043 (3.0); 7.3929 (2.8); 7.3905 (2.3); 7.3753 (1.6); 7.3599 (1.2); 7.2625 (3.0); 7.2221 (1.7); 7.2181 (1.8); 7.2053 (1.5); 7.2013 (1.5); 6.6373 (0.6); 6.6254 (1.2); 6.6135 (0.7); 6.0128 (0.6); 6.0068 (0.6); 5.9984 (0.7); 5.9924 (0.6); 5.9193 (0.6); 5.9133 (0.6); 5.9050 (0.7); 5.8989 (0.6); 5.2963 (1.4); 4.1858 (0.3); 4.1796 (0.3); 4.1726 (0.4); 4.1663 (0.4); 4.1564 (0.4); 4.1502 (0.4); 4.1432 (0.4); 4.1369 (0.4); 4.1308 (0.4); 4.1246 (0.4); 4.1175 (0.4); 4.1113 (0.4); 4.1014 (0.4); 4.0952 (0.4); 4.0881 (0.4); 4.0819 (0.4); 3.8523 (0.4); 3.8407 (0.4); 3.8382 (0.5); 3.8264 (0.4); 3.8231 (0.4); 3.8093 (0.8); 3.7974 (0.8); 3.7835 (0.4); 3.7802 (0.4); 3.7685 (0.4); 3.7659 (0.4); 2.9332 (0.5); 2.8414 (0.5); 2.5753 (16.0); 2.2696 (16.0); -0.0002 (3.4)
I-743:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2706 (16.0); 7.8417 (1.8); 7.8314 (1.1); 7.6153 (1.4); 7.6017 (2.5); 7.5883 (1.6); 7.5023 (1.3); 7.4868 (2.8); 7.4720 (1.7); 7.4253 (5.0); 7.4085 (6.2); 7.4032 (4.6); 7.3995 (7.3); 7.3971 (6.9); 7.3812 (3.7); 7.3650 (1.5); 7.2607 (9.8); 7.2377 (3.7); 7.2337 (3.7); 7.2209 (3.1); 7.2169 (3.1); 7.0227 (2.6); 6.9133 (5.4); 6.8040 (2.7); 6.0671 (1.2); 6.0608 (1.3); 6.0533 (1.3); 6.0469 (1.3); 5.9741 (1.2); 5.9677 (1.3); 5.9602 (1.4); 5.9539 (1.3); 5.2977 (0.5); 4.2747 (0.7); 4.2682 (0.7); 4.2614 (0.7); 4.2549 (0.8); 4.2453 (0.8); 4.2389 (0.9); 4.2321 (0.8); 4.2255 (0.9); 4.2220 (0.9); 4.2154 (0.7); 4.2086 (0.8); 4.2021 (0.7); 4.1925 (0.9); 4.1861 (0.8); 4.1793 (0.9); 4.1728 (0.8); 3.8745 (0.8); 3.8639 (0.9); 3.8607 (0.9); 3.8501 (0.8); 3.8452 (0.8); 3.8343 (0.8); 3.8311 (1.6); 3.8205 (1.6); 3.8173 (1.0); 3.8065 (0.8); 3.8016 (0.8); 3.7910 (0.8); 3.7878 (0.8); 3.7772 (0.7); 2.1680 (0.8); 1.5663 (0.5); 1.2563 (0.6); 0.0063 (0.4); -0.0002 (11.3); -0.0066 (0.6)
I-744:1 H-NMR(499.9 MHz, CDCl3): δ= 8.2702 (16.0); 7.8522 (1.4); 7.8420 (2.0); 7.6152 (1.8); 7.6015 (2.9); 7.5881 (1.9); 7.5023 (1.7); 7.4868 (3.3); 7.4720 (2.1); 7.4253 (5.8); 7.4085 (7.2); 7.4031 (5.3); 7.3994 (7.9); 7.3971 (7.3); 7.3811 (4.0); 7.3649 (1.7); 7.2608 (9.6); 7.2376 (4.1); 7.2336 (3.9); 7.2209 (3.4); 7.2168 (3.2); 7.0226 (2.8); 6.9132 (5.7); 6.8039 (2.8); 6.0670 (1.4); 6.0607 (1.5); 6.0532 (1.5); 6.0468 (1.4); 5.9740 (1.4); 5.9676 (1.5); 5.9602 (1.5); 5.9538 (1.3); 5.2977 (0.9); 4.2744 (0.9); 4.2679 (0.9); 4.2610 (0.9); 4.2546 (0.9); 4.2450 (1.0); 4.2385 (1.0); 4.2317 (1.0); 4.2252 (1.1); 4.2217 (1.0); 4.2151 (0.9); 4.2083 (0.9); 4.2018 (0.8); 4.1922 (1.0); 4.1857 (0.9); 4.1789 (1.0); 4.1724 (0.9); 3.8743 (1.0); 3.8637 (1.1); 3.8605 (1.1); 3.8499 (1.0); 3.8450 (0.9); 3.8342 (1.0); 3.8309 (1.8); 3.8204 (1.8); 3.8171 (1.2); 3.8063 (1.0); 3.8014 (0.9); 3.7909 (0.9); 3.7876 (0.9); 3.7770 (0.7); 2.1677 (0.8); 1.5616 (1.9); 1.2560 (0.6); 0.0062 (0.6); -0.0002 (10.9); -0.0067 (0.6)
I-745:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3336 (5.3); 7.3084 (2.9); 7.2990 (2.9); 7.2822 (3.4); 7.2559 (1.4); 7.1255 (1.6); 7.0999 (1.9); 7.0030 (2.9); 6.9912 (3.7); 6.9857 (5.1); 6.9590 (4.7); 6.9529 (4.4); 6.9164 (3.8); 6.8871 (1.2); 6.8607 (3.1); 6.8353 (1.6); 6.2728 (4.7); 4.5449 (0.5); 4.4271 (5.3); 3.7884 (0.6); 3.7719 (0.6); 3.7524 (0.5); 3.6868 (0.4); 3.4644 (0.7); 3.4517 (16.0); 3.4296 (0.4); 3.4180 (0.3); 3.3846 (0.4); 3.2579 (0.8); 3.2405 (0.5); 3.1947 (15.2); 3.0372 (1.4); 3.0121 (2.7); 2.9870 (1.3); 2.8538 (1.5); 2.8319 (2.6); 2.8100 (1.0); 2.7335 (0.4); 2.6989 (12.6); 2.5472 (14.0); 2.3984 (10.4); 2.3691 (10.4); 2.3324 (0.7); 2.3246 (0.5); 2.3006 (9.9); 2.2582 (0.4); 2.2477 (0.4); 2.0354 (1.8); 1.9649 (11.0); 1.9345 (1.4); 1.9244 (1.0); 1.9183 (0.9); 1.9077 (1.5); 1.8909 (0.8); 1.8805 (0.6); 1.7596 (0.6); 1.0296 (0.7); 1.0146 (2.0); 1.0073 (2.1); 1.0017 (2.8); 0.9941 (2.7); 0.9863 (2.4); 0.9796 (2.7); 0.9735 (2.3); 0.9658 (2.4); 0.9521 (0.9); 0.7650 (0.8); 0.7497 (2.2); 0.7440 (2.1); 0.7337 (2.1); 0.7261 (3.2); 0.7171 (2.3); 0.7065 (2.0); 0.7005 (2.4); 0.6842 (0.7); 0.0410 (2.7)
I-746:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4988 (2.1); 7.4721 (2.1); 7.3054 (2.2); 7.2987 (6.9); 7.1361 (0.4); 7.1096 (1.4); 7.0824 (2.4); 7.0732 (1.3); 7.0581 (0.9); 7.0522 (1.1); 7.0313 (0.5); 7.0250 (0.4); 7.0018 (1.1); 6.9751 (1.0); 6.8557 (0.6); 6.8479 (0.6); 6.8327 (1.1); 6.8264 (0.9); 6.8078 (0.6); 6.8019 (0.5); 6.4765 (0.4); 6.4553 (0.8); 6.4346 (0.4); 4.4886 (0.9); 4.4672 (0.8); 4.4417 (1.9); 4.4202 (1.8); 4.3947 (0.9); 4.3732 (0.9); 3.3952 (0.4); 2.4155 (0.4); 2.3946 (16.0); 2.3367 (7.9); 2.1310 (0.4); 2.1200 (0.5); 2.1029 (0.8); 2.0859 (0.5); 2.0747 (0.5); 1.6082 (0.5); 1.3021 (0.6); 1.0809 (0.6); 1.0655 (1.6); 1.0587 (1.8); 1.0440 (1.0); 1.0369 (1.8); 1.0303 (1.6); 1.0158 (0.8); 0.9183 (0.6); 0.8195 (0.8); 0.8044 (2.0); 0.7986 (1.9); 0.7876 (1.7); 0.7819 (2.1); 0.7654 (0.6); 0.0363 (7.8)
I-747:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4382 (2.0); 7.4100 (2.4); 7.2991 (9.9); 7.2707 (2.1); 7.1328 (1.2); 7.1149 (1.7); 7.1046 (1.2); 7.0895 (3.2); 7.0821 (1.6); 7.0673 (1.0); 7.0616 (1.3); 7.0406 (0.4); 7.0344 (0.4); 6.8606 (0.7); 6.8523 (0.7); 6.8376 (1.2); 6.8311 (1.1); 6.8127 (0.6); 6.8065 (0.6); 6.5161 (0.5); 6.4954 (0.9); 6.4755 (0.5); 4.2972 (1.0); 4.2759 (0.9); 4.2497 (2.0); 4.2284 (2.0); 4.2021 (1.0); 4.1809 (1.0); 2.5660 (6.6); 2.3811 (16.0); 2.1300 (0.5); 2.1184 (0.6); 2.1017 (1.0); 2.0843 (0.6); 2.0735 (0.6); 1.5998 (4.3); 1.3667 (0.4); 1.3425 (1.0); 1.3022 (6.1); 1.0785 (0.6); 1.0629 (1.8); 1.0563 (2.1); 1.0417 (1.1); 1.0345 (2.0); 1.0279 (1.9); 1.0136 (0.9); 0.9403 (2.1); 0.9189 (6.1); 0.8956 (2.4); 0.8181 (0.9); 0.8025 (2.3); 0.7974 (2.3); 0.7863 (2.0); 0.7803 (2.5); 0.7641 (0.7); 0.0477 (0.4); 0.0370 (12.5)
I-748:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4390 (2.2); 7.3718 (1.5); 7.3438 (2.9); 7.2989 (21.1); 7.2607 (0.8); 7.1450 (0.5); 7.1189 (1.6); 7.0927 (3.1); 7.0844 (1.4); 7.0692 (1.0); 7.0639 (1.3); 7.0427 (0.5); 7.0362 (0.4); 6.8634 (0.7); 6.8554 (0.7); 6.8404 (1.3); 6.8335 (1.1); 6.8152 (0.7); 6.8098 (0.6); 6.4741 (0.5); 6.4532 (0.9); 6.4344 (0.5); 4.3006 (1.0); 4.2789 (0.9); 4.2530 (2.1); 4.2318 (2.0); 4.2056 (1.0); 4.1842 (1.0); 2.5652 (6.6); 2.3864 (16.0); 2.1336 (0.5); 2.1219 (0.6); 2.1050 (1.0); 2.0885 (0.6); 2.0769 (0.6); 1.5905 (12.2); 1.3426 (0.5); 1.3025 (3.4); 1.0806 (0.6); 1.0652 (1.9); 1.0585 (2.1); 1.0437 (1.1); 1.0368 (2.0); 1.0303 (2.0); 1.0156 (0.9); 0.9407 (1.1); 0.9191 (3.3); 0.8956 (1.3); 0.8210 (0.8); 0.8058 (2.3); 0.8010 (2.3); 0.7890 (2.0); 0.7835 (2.5); 0.7669 (0.7); 0.0479 (0.9); 0.0370 (26.9); 0.0264 (1.2)
I-749:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3188 (2.6); 7.2975 (1.9); 7.2660 (1.6); 7.1740 (1.7); 7.1484 (1.2); 7.1094 (0.4); 7.0803 (1.5); 7.0610 (2.6); 6.8140 (1.4); 6.6368 (1.2); 5.3332 (1.2); 4.2169 (0.8); 4.1990 (0.8); 4.1690 (1.5); 4.1528 (1.4); 4.1246 (0.8); 2.3611 (8.3); 2.2773 (16.0); 2.1089 (0.7); 2.0838 (1.0); 2.0704 (0.9); 1.6555 (1.4); 1.0435 (2.4); 1.0204 (2.3); 0.7810 (3.1); 0.0382 (1.0)
I-750:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5529 (0.6); 7.5305 (1.1); 7.5088 (0.7); 7.4286 (0.5); 7.4024 (1.2); 7.3787 (0.9); 7.3656 (2.1); 7.3385 (3.5); 7.3102 (1.6); 7.2993 (1.7); 7.2836 (0.6); 7.0765 (2.4); 7.0703 (2.2); 6.9824 (1.3); 6.9558 (1.1); 6.8861 (2.4); 6.7788 (0.6); 6.7582 (1.1); 6.7376 (0.6); 6.7036 (1.2); 4.2559 (0.9); 4.2349 (0.9); 4.2076 (1.9); 4.1866 (1.8); 4.1592 (1.0); 4.1382 (0.9); 3.1977 (0.4); 2.5160 (6.7); 2.3712 (0.4); 2.3445 (16.0); 2.3168 (9.2); 1.6748 (0.8); 1.3047 (1.2); 0.9425 (0.4); 0.9210 (1.1); 0.8977 (0.4); 0.0396 (1.6)
I-751:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2743 (0.3); 7.4116 (3.2); 7.3850 (3.7); 7.2985 (20.5); 7.1257 (1.0); 7.0990 (2.8); 7.0713 (7.4); 7.0628 (5.9); 7.0479 (2.0); 7.0417 (2.3); 7.0209 (0.9); 7.0146 (0.8); 6.9580 (2.0); 6.9311 (1.7); 6.8626 (1.2); 6.8547 (1.2); 6.8396 (2.2); 6.8332 (1.8); 6.8147 (1.1); 6.8088 (1.0); 6.3287 (0.8); 6.3097 (1.5); 6.2891 (0.8); 4.3102 (1.8); 4.2895 (1.7); 4.2624 (3.9); 4.2417 (3.7); 4.2145 (1.9); 4.1938 (1.9); 4.1676 (0.4); 4.1438 (0.4); 2.5285 (10.9); 2.5215 (6.3); 2.3653 (0.4); 2.2952 (14.5); 2.1461 (0.4); 2.1289 (0.8); 2.1179 (0.9); 2.1008 (1.7); 2.0809 (2.5); 2.0729 (1.0); 2.0549 (0.5); 1.5885 (16.0); 1.3201 (0.5); 1.2963 (1.1); 1.2725 (0.5); 1.0795 (1.3); 1.0642 (3.3); 1.0574 (3.6); 1.0514 (2.0); 1.0425 (2.0); 1.0355 (3.5); 1.0290 (3.2); 1.0143 (1.6); 0.8157 (1.8); 0.8006 (4.0); 0.7946 (3.8); 0.7836 (3.5); 0.7781 (4.2); 0.7616 (1.3); 0.1085 (2.8); 0.0494 (0.8); 0.0386 (23.7); 0.0277 (0.9)
I-752:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4808 (0.4); 7.4753 (0.4); 7.3814 (0.5); 7.3622 (0.7); 7.3574 (0.7); 7.2991 (11.1); 7.0506 (0.7); 5.3390 (1.4); 5.1214 (0.4); 4.9272 (0.4); 2.2830 (2.8); 1.5879 (16.0); 1.0442 (0.3); 1.0372 (0.4); 1.0102 (0.8); 0.9871 (1.3); 0.9634 (0.6); 0.7933 (0.4); 0.7894 (0.4); 0.7762 (0.4); 0.7718 (0.3); 0.1069 (0.6); 0.0486 (0.4); 0.0377 (10.8); 0.0269 (0.5)
I-753:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5073 (0.7); 7.4998 (0.8); 7.4818 (1.2); 7.4762 (1.1); 7.3936 (0.4); 7.3881 (0.4); 7.3769 (1.4); 7.3660 (0.9); 7.3581 (2.0); 7.3526 (2.0); 7.3425 (0.5); 7.2990 (12.3); 7.0725 (0.8); 7.0576 (0.6); 7.0491 (1.8); 7.0357 (0.5); 7.0294 (0.7); 6.8372 (0.3); 6.8155 (0.6); 6.8077 (0.5); 5.3385 (1.5); 5.1689 (0.9); 5.1186 (1.3); 4.9132 (1.2); 4.8629 (0.8); 3.6513 (0.4); 3.6251 (0.9); 3.6035 (0.9); 3.5956 (0.9); 3.5754 (0.9); 3.5697 (0.5); 3.5494 (0.3); 2.2597 (7.9); 2.1420 (0.5); 2.1124 (0.5); 1.6634 (0.3); 1.6414 (0.4); 1.6195 (0.4); 1.5912 (16.0); 1.0446 (0.9); 1.0380 (1.0); 1.0277 (0.5); 1.0225 (0.4); 1.0160 (0.9); 1.0095 (1.0); 0.9947 (0.4); 0.8072 (0.4); 0.7906 (1.0); 0.7865 (0.9); 0.7761 (1.0); 0.7690 (0.7); 0.7565 (0.3); 0.6936 (3.5); 0.6711 (3.4); 0.6460 (3.6); 0.6235 (3.4); 0.1070 (0.6); 0.0485 (0.4); 0.0376 (11.5); 0.0268 (0.5)
I-754:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2132 (0.8); 8.1882 (0.8); 8.1198 (5.2); 7.4036 (1.1); 7.3772 (2.5); 7.3509 (1.5); 7.2985 (5.8); 7.1353 (1.8); 7.1097 (2.1); 7.0810 (1.3); 7.0550 (1.1); 6.9429 (0.9); 6.9400 (1.0); 6.9349 (1.3); 6.9318 (1.4); 6.9171 (2.2); 6.9082 (1.2); 6.9053 (1.0); 6.8660 (1.6); 6.8597 (2.1); 6.8528 (1.2); 6.8246 (1.1); 6.7992 (0.9); 5.3362 (13.8); 5.3105 (0.6); 5.2872 (1.6); 5.2625 (1.6); 5.2393 (0.6); 3.3451 (0.3); 3.2978 (1.5); 3.2756 (2.8); 3.2534 (1.5); 3.2291 (0.3); 2.7436 (16.0); 2.3527 (11.2); 2.2455 (10.3); 2.0012 (0.5); 1.9901 (0.6); 1.9849 (0.4); 1.9733 (1.1); 1.9618 (0.4); 1.9565 (0.6); 1.9454 (0.6); 1.6078 (4.6); 1.2974 (0.3); 1.0843 (0.7); 1.0691 (1.8); 1.0623 (2.0); 1.0567 (1.0); 1.0473 (1.1); 1.0407 (2.0); 1.0342 (1.7); 1.0194 (0.9); 0.8004 (0.9); 0.7851 (2.3); 0.7792 (2.0); 0.7687 (1.8); 0.7629 (2.4); 0.7466 (0.7); 0.0389 (7.2)
I-755:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3817 (0.4); 9.3665 (0.9); 9.3509 (0.4); 9.0947 (0.8); 9.0797 (1.6); 9.0642 (0.8); 8.3163 (1.0); 7.7524 (0.5); 7.7432 (0.9); 7.7330 (1.4); 7.7239 (2.2); 7.7134 (1.4); 7.7040 (2.2); 7.6928 (8.2); 7.6801 (2.5); 7.6610 (1.6); 7.6400 (0.4); 7.6222 (2.8); 7.5890 (1.6); 7.5619 (2.3); 7.5417 (2.1); 7.3544 (1.2); 7.3344 (1.4); 7.3200 (2.4); 7.3000 (2.7); 7.1054 (1.6); 7.0755 (3.0); 7.0538 (0.4); 6.9622 (0.8); 6.9306 (1.7); 6.9109 (1.5); 4.1837 (0.4); 4.1691 (0.4); 4.1448 (0.9); 4.1315 (1.5); 4.1166 (1.0); 4.0953 (2.1); 4.0797 (1.8); 4.0583 (1.0); 4.0431 (0.9); 3.9842 (2.4); 3.9793 (2.4); 3.9744 (2.4); 3.9528 (2.9); 3.4987 (1.2); 3.4915 (1.3); 3.4709 (2.4); 3.4633 (2.2); 3.4437 (1.3); 3.4351 (1.2); 3.3375 (315.2); 3.3046 (1.8); 3.2868 (0.6); 3.2703 (1.2); 3.2544 (1.4); 3.2415 (0.7); 3.2057 (0.8); 3.1947 (1.0); 3.1783 (1.0); 3.1667 (1.4); 3.1522 (0.8); 3.1400 (0.7); 3.1270 (0.4); 2.7789 (0.4); 2.7614 (0.3); 2.6811 (0.9); 2.6766 (1.3); 2.6722 (1.0); 2.5469 (4.7); 2.5121 (165.2); 2.5076 (217.9); 2.5032 (166.6); 2.4237 (9.6); 2.3836 (1.0); 2.3388 (1.1); 2.3345 (1.4); 2.3299 (1.1); 2.2913 (0.5); 2.2799 (0.5); 2.2471 (6.4); 2.2242 (11.8); 2.1707 (0.6); 2.0777 (16.0); 1.8130 (2.5); 1.8031 (3.3); 1.7884 (2.8); 1.7773 (2.0); 1.7596 (0.9); 1.7551 (0.8); 1.7488 (1.0); 1.7268 (0.4); 1.7164 (0.3); 1.5888 (1.0); 1.5605 (0.9); 1.3987 (0.4)
I-756:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4570 (2.6); 7.4290 (3.2); 7.4072 (2.1); 7.4018 (2.8); 7.3968 (2.3); 7.3665 (0.4); 7.2988 (15.9); 7.2015 (1.9); 7.1948 (1.9); 7.1736 (1.6); 7.1669 (1.6); 7.1275 (1.1); 7.1162 (0.8); 7.1000 (3.2); 7.0946 (2.3); 7.0809 (4.1); 7.0663 (1.9); 7.0469 (0.5); 6.8417 (0.8); 6.8275 (0.9); 6.8200 (1.1); 6.8111 (1.3); 6.7956 (0.8); 6.7878 (0.7); 6.0895 (0.6); 6.0788 (0.6); 6.0672 (0.7); 6.0563 (0.6); 5.9348 (0.6); 5.9242 (0.6); 5.9125 (0.7); 5.9017 (0.6); 4.2573 (0.3); 4.2465 (0.3); 4.2355 (0.3); 4.2247 (0.3); 4.2085 (0.4); 4.1972 (0.5); 4.1867 (0.4); 4.1714 (0.9); 4.1597 (0.4); 4.1482 (0.8); 4.1377 (0.3); 4.1222 (0.5); 4.1110 (0.4); 4.0997 (0.4); 4.0888 (0.4); 3.8930 (0.4); 3.8750 (0.5); 3.8709 (0.5); 3.8528 (0.4); 3.8445 (0.4); 3.8177 (0.6); 3.7994 (0.6); 3.7773 (0.5); 3.7688 (0.4); 3.7506 (0.4); 3.7463 (0.4); 3.1000 (0.5); 3.0902 (0.7); 3.0774 (1.0); 3.0684 (1.0); 3.0558 (0.8); 3.0458 (0.5); 2.1479 (0.6); 2.1371 (0.6); 2.1198 (1.2); 2.1028 (0.7); 2.0918 (0.7); 2.0828 (2.4); 1.5906 (16.0); 1.3453 (0.4); 1.3211 (1.3); 1.3050 (2.6); 1.2975 (3.2); 1.2736 (0.8); 1.0774 (0.8); 1.0620 (2.2); 1.0553 (2.5); 1.0406 (1.3); 1.0335 (2.4); 1.0269 (2.2); 1.0124 (1.1); 0.9422 (1.0); 0.9204 (3.0); 0.9078 (0.7); 0.8964 (2.6); 0.8893 (2.4); 0.8661 (2.4); 0.8546 (0.8); 0.8474 (0.7); 0.8224 (1.2); 0.8073 (2.8); 0.8014 (2.8); 0.7904 (2.6); 0.7848 (3.0); 0.7684 (1.0); 0.7291 (0.8); 0.7133 (2.5); 0.7053 (2.4); 0.7009 (2.4); 0.6935 (1.8); 0.6777 (0.6); 0.0490 (0.6); 0.0383 (20.0); 0.0273 (0.8)
I-757:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3427 (3.9); 7.3357 (4.2); 7.2990 (14.6); 7.2023 (3.2); 7.1750 (4.0); 7.1203 (0.8); 7.0934 (2.2); 7.0663 (3.2); 7.0554 (2.1); 7.0398 (1.5); 7.0340 (1.9); 7.0129 (0.8); 7.0069 (0.7); 6.9948 (2.5); 6.9878 (2.4); 6.9675 (2.0); 6.9604 (1.9); 6.9010 (0.8); 6.8354 (1.0); 6.8277 (1.0); 6.8121 (1.8); 6.8064 (1.5); 6.7873 (0.9); 6.7816 (0.9); 3.8190 (1.4); 3.7973 (3.8); 3.7762 (3.9); 3.7546 (1.6); 3.1963 (9.9); 3.1781 (9.9); 3.0943 (2.9); 3.0721 (5.4); 3.0498 (2.6); 2.1253 (0.7); 2.1140 (0.8); 2.0968 (1.4); 2.0823 (1.4); 2.0688 (0.8); 2.0515 (0.4); 1.5935 (16.0); 1.3211 (0.4); 1.3046 (0.9); 1.2975 (1.0); 1.0750 (1.0); 1.0596 (2.6); 1.0529 (2.9); 1.0382 (1.6); 1.0310 (2.9); 1.0245 (2.7); 1.0100 (1.3); 0.9204 (0.9); 0.8973 (0.3); 0.8174 (1.3); 0.8021 (3.2); 0.7964 (3.2); 0.7853 (2.9); 0.7795 (3.5); 0.7633 (1.0); 0.0492 (0.6); 0.0384 (18.0); 0.0275 (0.8)
I-758:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.3152 (0.5); 7.6629 (0.6); 7.6600 (0.6); 7.6567 (0.6); 7.6147 (0.7); 7.5866 (0.9); 7.3842 (0.5); 7.3773 (0.5); 7.3562 (0.4); 7.3493 (0.4); 7.1829 (0.5); 7.1563 (0.4); 7.1205 (0.3); 7.0971 (0.4); 6.9606 (0.4); 6.4762 (0.4); 6.4591 (0.4); 4.0386 (0.4); 3.3406 (16.0); 2.5348 (0.8); 2.5288 (1.6); 2.5227 (2.4); 2.5167 (1.7); 2.5107 (0.8); 2.0906 (0.4); 2.0098 (1.4); 1.2195 (0.4); 1.1958 (0.7); 1.1721 (0.4); 1.0599 (0.6); 1.0526 (0.6); 1.0392 (0.4); 1.0318 (0.6); 1.0245 (0.6); 0.8122 (0.6); 0.8059 (0.7); 0.7955 (0.6); 0.7889 (0.7); 0.0206 (0.8)
I-759:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.0413 (0.4); 9.0222 (0.9); 9.0032 (0.4); 7.5524 (1.8); 7.5452 (1.8); 7.4393 (1.4); 7.4117 (1.7); 7.2161 (1.1); 7.2088 (1.4); 7.1886 (1.0); 7.1812 (1.8); 7.1529 (0.9); 7.1174 (0.5); 7.1116 (0.6); 7.0882 (0.8); 7.0663 (0.4); 6.9859 (0.4); 6.9802 (0.4); 6.9600 (0.8); 6.9375 (0.4); 6.9324 (0.3); 3.6318 (0.4); 3.6093 (1.2); 3.5892 (1.2); 3.5670 (0.5); 3.3403 (16.0); 3.0171 (0.8); 2.9944 (1.8); 2.9714 (0.8); 2.5345 (1.2); 2.5286 (2.7); 2.5226 (3.8); 2.5165 (2.8); 2.5107 (1.3); 2.1136 (0.3); 2.1027 (0.4); 2.0861 (0.6); 2.0684 (0.4); 2.0576 (0.4); 1.0738 (0.4); 1.0589 (1.1); 1.0517 (1.2); 1.0381 (0.7); 1.0309 (1.1); 1.0236 (1.2); 1.0103 (0.5); 0.8253 (0.5); 0.8115 (1.2); 0.8052 (1.4); 0.7947 (1.3); 0.7881 (1.4); 0.7727 (0.4); 0.0204 (2.7)
I-760:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8868 (1.2); 7.8429 (1.0); 7.3560 (2.1); 7.3294 (2.4); 7.2987 (9.4); 7.1009 (0.6); 7.0732 (1.8); 7.0491 (3.5); 7.0260 (4.0); 7.0057 (0.7); 6.9993 (0.5); 6.9200 (1.4); 6.8946 (1.3); 6.8164 (0.8); 6.8073 (0.8); 6.7940 (1.5); 6.7871 (1.2); 6.7689 (0.8); 6.7629 (0.7); 4.2199 (1.2); 4.2001 (1.2); 4.1727 (2.4); 4.1529 (2.3); 4.1253 (1.2); 4.1057 (1.2); 3.0162 (0.5); 3.0061 (0.8); 2.9942 (1.1); 2.9836 (1.1); 2.9717 (0.8); 2.9609 (0.5); 2.8431 (16.0); 2.4899 (7.6); 2.2909 (10.4); 2.1493 (0.6); 2.1380 (0.7); 2.1209 (1.2); 2.1037 (0.7); 2.0929 (0.7); 2.0752 (0.4); 1.6164 (6.7); 1.0681 (0.8); 1.0525 (2.3); 1.0460 (2.4); 1.0313 (1.4); 1.0242 (2.3); 1.0177 (2.2); 1.0033 (1.0); 0.9082 (0.6); 0.8853 (2.6); 0.8679 (2.7); 0.8455 (1.0); 0.8164 (1.2); 0.8011 (2.8); 0.7959 (2.8); 0.7845 (2.6); 0.7791 (2.9); 0.7626 (0.9); 0.7269 (1.0); 0.7115 (2.5); 0.7034 (2.8); 0.6748 (0.6); 0.1081 (1.0); 0.0381 (8.4)
I-761:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4636 (4.2); 7.4356 (5.4); 7.4136 (4.6); 7.3651 (0.3); 7.3416 (0.4); 7.3343 (0.4); 7.2988 (18.2); 7.2373 (4.0); 7.2307 (4.0); 7.2095 (3.1); 7.2027 (2.9); 7.1219 (0.6); 7.0951 (6.7); 7.0769 (5.4); 7.0679 (3.4); 7.0495 (0.8); 6.8342 (1.3); 6.8178 (1.8); 6.8128 (1.6); 6.8029 (2.1); 6.7889 (1.2); 6.7802 (1.1); 6.0903 (0.9); 6.0799 (1.0); 6.0682 (1.0); 6.0576 (0.9); 5.9357 (0.9); 5.9250 (1.0); 5.9134 (1.0); 5.9031 (1.0); 5.3368 (16.0); 4.2428 (0.4); 4.2322 (0.4); 4.2216 (0.4); 4.2111 (0.4); 4.1944 (0.9); 4.1831 (0.6); 4.1708 (1.6); 4.1605 (0.7); 4.1468 (1.4); 4.1353 (0.5); 4.1234 (0.8); 4.1075 (0.6); 4.0967 (0.6); 4.0863 (0.6); 4.0752 (0.5); 3.9269 (0.6); 3.9061 (0.9); 3.8855 (0.6); 3.8779 (0.5); 3.8515 (0.8); 3.8306 (1.0); 3.8097 (0.6); 3.8024 (0.6); 3.7812 (0.7); 3.7604 (0.5); 3.1979 (10.0); 3.1797 (10.0); 2.1609 (0.4); 2.1438 (1.0); 2.1327 (1.0); 2.1155 (2.0); 2.0981 (1.2); 2.0821 (5.0); 2.0702 (0.6); 1.5990 (11.2); 1.3681 (0.4); 1.3442 (1.0); 1.3204 (2.9); 1.3045 (6.5); 1.2969 (7.4); 1.2729 (1.7); 1.0732 (1.3); 1.0577 (3.7); 1.0510 (3.9); 1.0365 (2.1); 1.0292 (3.8); 1.0226 (3.7); 1.0083 (1.7); 0.9416 (2.3); 0.9199 (7.3); 0.8966 (2.7); 0.8164 (1.7); 0.8011 (4.4); 0.7958 (4.3); 0.7845 (3.9); 0.7785 (4.7); 0.7625 (1.3); 0.0487 (0.6); 0.0380 (20.4); 0.0270 (0.8)
I-762:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3205 (9.7); 8.1422 (0.7); 8.1239 (1.0); 7.3387 (2.2); 7.3119 (2.7); 7.2988 (10.6); 7.1927 (0.4); 7.1663 (5.6); 7.1523 (2.9); 7.1486 (4.3); 7.1430 (3.1); 7.1401 (2.9); 7.1217 (0.7); 7.0244 (6.0); 6.9994 (1.7); 6.9240 (1.1); 6.9061 (1.3); 6.9024 (1.3); 6.8926 (1.8); 6.8791 (0.9); 6.8701 (0.8); 6.0094 (0.7); 5.9994 (0.8); 5.9824 (0.8); 5.9725 (0.8); 5.8511 (0.7); 5.8411 (0.8); 5.8242 (0.8); 5.8143 (0.7); 4.2659 (0.4); 4.2560 (0.4); 4.2427 (0.4); 4.2326 (0.5); 4.2172 (0.5); 4.2071 (0.5); 4.1948 (0.6); 4.1840 (0.6); 4.1723 (0.8); 4.1672 (0.5); 4.1568 (0.4); 4.1485 (0.8); 4.1440 (0.6); 4.1335 (0.4); 4.1248 (0.4); 4.1183 (0.6); 4.1083 (0.5); 4.0952 (0.6); 4.0850 (0.5); 3.7861 (0.5); 3.7701 (0.5); 3.7591 (0.5); 3.7431 (0.6); 3.7377 (0.5); 3.7237 (0.7); 3.7093 (0.9); 3.6956 (0.7); 3.6815 (0.6); 3.6760 (0.5); 3.6599 (0.4); 3.6488 (0.4); 3.6329 (0.4); 2.4079 (16.0); 2.3649 (0.4); 2.3137 (13.8); 2.1909 (0.4); 2.1732 (0.8); 2.1622 (0.8); 2.1449 (1.5); 2.1276 (0.9); 2.1166 (0.8); 2.0994 (0.5); 2.0836 (3.4); 1.5999 (7.9); 1.3218 (1.0); 1.2979 (2.3); 1.2742 (0.9); 1.1100 (1.0); 1.0946 (2.8); 1.0879 (3.0); 1.0731 (1.6); 1.0661 (3.0); 1.0595 (2.8); 1.0449 (1.3); 0.8492 (1.4); 0.8340 (3.4); 0.8282 (3.3); 0.8171 (3.0); 0.8114 (3.6); 0.7951 (1.0); 0.1096 (0.4); 0.0500 (0.4); 0.0391 (12.6); 0.0281 (0.5)
I-763:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5752 (1.4); 7.5559 (3.8); 7.5528 (3.8); 7.5364 (0.3); 7.5054 (1.8); 7.4546 (0.8); 7.4441 (1.1); 7.4370 (0.9); 7.4242 (0.7); 7.4163 (0.4); 7.3166 (1.4); 7.2988 (4.2); 7.2890 (1.7); 7.0637 (1.3); 7.0400 (3.4); 6.6516 (0.5); 6.6318 (0.7); 6.6126 (0.5); 5.9825 (0.4); 5.9728 (0.5); 5.9552 (0.5); 5.9454 (0.4); 5.8239 (0.4); 5.8141 (0.5); 5.7965 (0.5); 5.7868 (0.4); 4.1807 (0.3); 4.1707 (0.3); 4.1568 (0.3); 4.1468 (0.3); 4.0811 (0.3); 4.0572 (0.3); 3.7291 (0.4); 3.7248 (0.3); 3.7126 (0.4); 3.7083 (0.3); 3.6965 (0.6); 3.6851 (0.4); 3.6807 (0.3); 3.6684 (0.4); 3.6642 (0.3); 2.4463 (16.0); 2.3960 (9.6); 2.3401 (8.4); 2.0768 (0.5); 1.6204 (2.3); 1.2944 (1.3); 0.0394 (4.3)
I-764:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2521 (1.3); 9.2370 (2.4); 9.2220 (1.2); 8.0951 (0.4); 8.0066 (12.0); 7.9595 (0.8); 7.7079 (0.6); 7.5238 (1.4); 7.5060 (2.4); 7.4879 (1.5); 7.4684 (1.1); 7.4486 (2.2); 7.4310 (1.6); 7.3706 (2.4); 7.3511 (3.1); 7.3318 (4.6); 7.3120 (3.8); 7.1440 (0.3); 7.0766 (4.4); 6.9463 (2.3); 6.9275 (2.1); 4.1322 (1.3); 4.1178 (1.3); 4.0954 (2.7); 4.0804 (2.6); 4.0581 (1.4); 4.0437 (1.3); 3.3137 (694.9); 3.2909 (3.0); 3.2711 (0.8); 3.2622 (0.6); 2.8976 (5.6); 2.7384 (4.8); 2.6767 (0.3); 2.5119 (43.9); 2.5075 (57.3); 2.5032 (42.2); 2.4275 (11.8); 2.3298 (0.5); 2.3113 (0.9); 2.2725 (0.9); 2.2451 (0.3); 2.2011 (16.0); 2.1801 (0.9); 1.4887 (0.9); 1.4696 (3.1); 1.4531 (1.2); 1.4415 (1.0); 1.4220 (3.0); 1.4056 (1.2); 1.2012 (1.2); 1.1804 (3.8); 1.1624 (3.9); 1.1413 (0.9)
I-765:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.1683 (1.6); 9.1540 (3.1); 9.1385 (1.5); 8.0934 (15.9); 7.9592 (2.4); 7.6457 (5.3); 7.5793 (5.3); 7.5583 (6.5); 7.5241 (1.5); 7.5049 (2.8); 7.4888 (2.9); 7.4724 (3.0); 7.4541 (1.9); 7.4032 (3.8); 7.3981 (3.7); 7.3822 (3.3); 7.3769 (3.4); 7.3713 (3.0); 7.3512 (3.6); 7.3312 (1.5); 6.0759 (1.1); 6.0646 (1.7); 6.0510 (1.1); 5.9603 (1.0); 5.9498 (1.7); 5.9354 (1.2); 3.9368 (0.4); 3.9153 (1.0); 3.8995 (2.6); 3.8854 (2.3); 3.8747 (1.3); 3.8590 (1.2); 3.8429 (2.2); 3.8287 (2.1); 3.8149 (1.0); 3.8038 (0.4); 3.7937 (0.3); 3.4380 (0.6); 3.3514 (3.6); 3.3133 (786.0); 3.2693 (0.7); 2.8976 (16.0); 2.7386 (13.7); 2.6762 (0.4); 2.5120 (48.7); 2.5075 (64.1); 2.5031 (46.6); 2.3344 (0.4); 2.3293 (0.3); 1.4865 (1.1); 1.4678 (3.7); 1.4511 (1.5); 1.4405 (1.2); 1.4201 (3.8); 1.4044 (1.5); 1.2048 (1.5); 1.1839 (4.6); 1.1663 (4.7); 1.1452 (1.0)
I-766:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3715 (0.7); 9.3555 (1.5); 9.3401 (0.7); 7.9591 (1.3); 7.5044 (0.7); 7.4861 (1.2); 7.4699 (0.8); 7.4093 (0.6); 7.3894 (1.3); 7.3720 (1.0); 7.3443 (2.5); 7.3244 (2.7); 7.3098 (0.6); 7.0999 (2.6); 6.9864 (1.4); 6.9672 (1.2); 4.1728 (0.7); 4.1575 (0.7); 4.1355 (1.4); 4.1199 (1.4); 4.0977 (0.8); 4.0823 (0.7); 3.3562 (0.7); 3.3152 (168.3); 3.2777 (0.4); 2.8974 (8.8); 2.7385 (7.6); 2.5120 (10.0); 2.5075 (13.1); 2.5032 (9.7); 2.4443 (6.9); 2.4126 (0.6); 2.2283 (10.9); 2.2217 (16.0); 1.4811 (0.5); 1.4613 (1.8); 1.4449 (0.7); 1.4341 (0.6); 1.4140 (1.8); 1.3983 (0.7); 1.3615 (0.7); 1.3459 (0.7); 1.1944 (0.7); 1.1739 (2.2); 1.1560 (2.2); 1.1347 (0.5)
I-767:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1663 (1.0); 8.1591 (5.6); 7.9894 (0.4); 7.9719 (0.7); 7.9534 (0.4); 7.6621 (0.5); 7.6512 (1.5); 7.6427 (1.5); 7.6321 (3.7); 7.6291 (3.4); 7.6109 (0.8); 7.5828 (0.4); 7.5169 (0.3); 7.4962 (1.9); 7.4687 (0.7); 7.4584 (1.1); 7.4511 (0.8); 7.4380 (0.8); 7.4303 (0.4); 7.3655 (1.7); 7.3389 (1.9); 7.2987 (8.8); 7.0669 (1.8); 6.9767 (1.0); 6.9496 (0.9); 4.3018 (0.9); 4.2820 (0.9); 4.2538 (2.0); 4.2341 (1.9); 4.2059 (1.0); 4.1861 (1.0); 2.6899 (16.0); 2.5152 (3.1); 2.5085 (5.6); 2.5012 (3.1); 2.3133 (7.6); 2.0443 (1.2); 1.5964 (1.9); 0.1088 (0.7); 0.0492 (0.4); 0.0385 (10.7); 0.0276 (0.3)
I-768:1 H-NMR(300.2 MHz, CDCl3): δ= 8.1186 (10.4); 7.9810 (0.9); 7.9631 (1.6); 7.9447 (0.9); 7.8975 (0.9); 7.6767 (0.5); 7.6502 (2.8); 7.6300 (7.7); 7.5591 (0.4); 7.4957 (3.9); 7.4685 (1.7); 7.4591 (2.5); 7.4517 (1.7); 7.4380 (1.7); 7.4310 (1.0); 7.3628 (3.4); 7.3362 (3.9); 7.2987 (12.0); 7.0659 (4.0); 6.9746 (2.2); 6.9482 (2.0); 4.2980 (1.8); 4.2784 (1.8); 4.2501 (3.9); 4.2304 (3.8); 4.2022 (2.0); 4.1824 (1.9); 3.4596 (0.7); 3.4360 (1.0); 3.4127 (0.8); 3.3472 (2.3); 3.3227 (7.1); 3.2982 (7.2); 3.2738 (2.4); 2.5068 (11.8); 2.3127 (16.0); 1.7694 (1.0); 1.5286 (0.7); 1.5045 (1.8); 1.4809 (1.8); 1.4562 (1.1); 1.4448 (7.7); 1.4204 (15.6); 1.3959 (7.2); 1.2927 (0.9); 0.1084 (1.8); 0.0378 (14.0); 0.0271 (0.6)
I-769:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 11.2190 (2.6); 9.1755 (1.2); 9.1630 (2.6); 9.1504 (1.3); 7.8885 (12.4); 7.4595 (3.9); 7.4421 (4.2); 7.4328 (2.9); 7.4273 (4.6); 7.4218 (3.0); 7.3558 (4.5); 7.3512 (5.0); 7.3473 (4.2); 7.3312 (4.2); 7.0871 (4.3); 6.9784 (2.2); 6.9624 (2.1); 6.9489 (3.0); 6.9443 (3.1); 6.9315 (2.8); 6.9269 (2.9); 6.4687 (2.3); 6.4647 (3.6); 6.4604 (2.5); 4.1247 (1.1); 4.1123 (1.1); 4.0951 (2.6); 4.0825 (2.6); 4.0652 (1.3); 4.0547 (1.5); 4.0408 (2.0); 4.0266 (2.0); 4.0123 (0.7); 3.3237 (8.5); 2.5118 (1.8); 2.5082 (3.8); 2.5046 (5.2); 2.5010 (3.9); 2.4975 (1.9); 2.4278 (11.0); 2.3566 (0.6); 2.3525 (0.4); 2.2873 (0.8); 2.2708 (0.4); 2.2292 (16.0); 2.1853 (0.4); 1.9923 (8.2); 1.2479 (0.7); 1.1928 (2.2); 1.1785 (4.4); 1.1643 (2.2); 0.8755 (0.4); 0.8618 (1.3); 0.8476 (0.6)
I-770:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3022 (16.0); 8.0327 (1.0); 8.0149 (1.7); 7.9965 (1.0); 7.5895 (6.1); 7.5398 (0.3); 7.5328 (1.0); 7.5284 (1.0); 7.5103 (9.4); 7.5029 (4.2); 7.4865 (5.7); 7.4609 (1.6); 7.4246 (1.5); 7.4190 (1.2); 7.3967 (6.3); 7.3912 (6.6); 7.3804 (12.5); 7.3691 (4.0); 7.3529 (2.0); 7.2988 (14.3); 7.2635 (2.3); 7.2558 (3.7); 7.2475 (1.9); 7.2397 (2.0); 7.2323 (3.4); 7.2244 (1.7); 6.1186 (1.3); 6.1080 (1.4); 6.0954 (1.4); 6.0847 (1.3); 5.9635 (1.3); 5.9528 (1.4); 5.9402 (1.4); 5.9295 (1.3); 4.3426 (0.7); 4.3318 (0.7); 4.3204 (0.7); 4.3095 (0.7); 4.2939 (0.9); 4.2831 (0.9); 4.2716 (0.9); 4.2608 (0.9); 4.2541 (0.8); 4.2432 (0.7); 4.2318 (0.8); 4.2209 (0.7); 4.2052 (0.9); 4.1944 (0.9); 4.1830 (0.9); 4.1721 (0.8); 3.9048 (0.9); 3.8876 (0.9); 3.8814 (0.9); 3.8643 (1.0); 3.8560 (0.8); 3.8387 (0.8); 3.8328 (1.7); 3.8157 (1.6); 3.8097 (1.0); 3.7925 (0.9); 3.7842 (0.8); 3.7670 (0.8); 3.7608 (0.7); 3.7437 (0.6); 3.1928 (13.9); 2.0436 (5.4); 1.6251 (1.0); 0.0477 (0.6); 0.0369 (17.8); 0.0258 (0.6)
I-771:1 H-NMR(400.1 MHz, CDCl3): δ= 8.8161 (9.5); 7.8647 (1.0); 7.8514 (1.7); 7.8377 (1.0); 7.6812 (0.4); 7.6607 (3.3); 7.6534 (3.0); 7.6469 (7.3); 7.5220 (3.7); 7.4871 (0.4); 7.4761 (1.4); 7.4672 (1.9); 7.4621 (1.8); 7.4535 (1.6); 7.4475 (1.1); 7.3423 (3.4); 7.3223 (3.8); 7.2640 (5.5); 7.0448 (4.1); 6.9504 (2.2); 6.9304 (2.1); 5.3003 (4.8); 4.2941 (1.0); 4.2792 (1.0); 4.2685 (0.8); 4.2580 (1.6); 4.2434 (1.5); 4.2316 (1.5); 4.2173 (1.6); 4.2063 (0.9); 4.1955 (1.2); 4.1809 (1.1); 3.3074 (0.4); 3.2888 (1.3); 3.2705 (1.6); 3.2547 (2.0); 3.2363 (1.9); 3.2179 (0.6); 3.0999 (0.5); 3.0815 (1.8); 3.0632 (2.1); 3.0473 (1.7); 3.0291 (1.4); 3.0108 (0.5); 2.4800 (11.5); 2.2846 (16.0); 1.6294 (6.7); 1.2720 (6.5); 1.2536 (14.7); 1.2351 (6.5); 0.0723 (0.8); -0.0002 (6.4)
I-772:1 H-NMR(400.1 MHz, CDCl3): δ= 9.8529 (0.6); 9.8259 (0.6); 8.1621 (5.4); 7.5911 (0.8); 7.5716 (2.3); 7.5611 (1.8); 7.5415 (1.9); 7.5219 (0.7); 7.2763 (3.1); 7.2613 (2.5); 7.2527 (1.7); 7.2487 (1.6); 7.2254 (1.4); 7.1906 (1.2); 7.1712 (1.2); 7.1167 (2.1); 7.0975 (2.2); 6.8899 (2.7); 6.4403 (1.4); 6.4213 (1.3); 6.0176 (1.8); 5.9945 (1.8); 2.7211 (16.0); 2.6921 (0.8); 2.6760 (0.6); 2.2888 (0.4); 2.2759 (0.6); 2.2552 (0.8); 2.2173 (12.8); 2.1294 (0.5); 2.0565 (0.6); 2.0417 (12.0); 1.9411 (0.5); 1.6328 (0.8); -0.0002 (2.9)
I-773:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3199 (1.6); 7.2984 (3.4); 7.1237 (0.4); 7.1058 (2.5); 7.0991 (2.0); 7.0967 (2.0); 7.0933 (1.8); 7.0806 (3.5); 7.0658 (0.4); 7.0517 (1.4); 7.0242 (3.5); 6.8437 (0.7); 6.8348 (0.6); 6.8216 (1.2); 6.8102 (0.9); 6.8035 (0.6); 6.7898 (0.5); 6.6951 (0.5); 6.6759 (0.8); 6.6564 (0.5); 5.9806 (0.4); 5.9706 (0.5); 5.9536 (0.5); 5.9435 (0.5); 5.8222 (0.4); 5.8122 (0.5); 5.7952 (0.5); 5.7851 (0.5); 5.3341 (0.4); 4.1631 (0.4); 4.1587 (0.4); 4.1481 (0.4); 4.1394 (0.4); 4.1352 (0.4); 4.1244 (0.3); 4.0599 (0.4); 4.0495 (0.3); 4.0363 (0.3); 3.7717 (0.3); 3.7616 (0.3); 3.7444 (0.4); 3.7404 (0.4); 3.7284 (0.4); 3.7234 (0.3); 3.7121 (0.6); 3.7012 (0.4); 3.6962 (0.4); 3.6842 (0.4); 3.6801 (0.4); 2.4573 (16.0); 2.3990 (10.1); 2.3306 (8.7); 2.1238 (0.6); 2.1129 (0.6); 2.0956 (1.0); 2.0782 (2.2); 2.0673 (0.6); 1.6567 (0.8); 1.3183 (0.4); 1.2945 (1.2); 1.2707 (0.4); 1.0632 (0.7); 1.0478 (1.8); 1.0411 (2.0); 1.0264 (1.1); 1.0193 (1.9); 1.0128 (1.8); 0.9982 (0.9); 0.8059 (0.9); 0.7908 (2.2); 0.7852 (2.2); 0.7739 (2.0); 0.7684 (2.3); 0.7519 (0.7); 0.0394 (2.2)
I-774:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5712 (1.5); 7.5521 (3.9); 7.5494 (3.8); 7.4754 (1.8); 7.4363 (0.8); 7.4253 (1.1); 7.4181 (1.0); 7.4056 (0.8); 7.3956 (2.1); 7.3685 (2.0); 7.2985 (11.4); 7.0955 (2.0); 7.0198 (1.1); 6.9930 (1.0); 6.3840 (0.5); 6.3634 (0.9); 6.3427 (0.5); 4.2907 (1.0); 4.2699 (0.9); 4.2420 (2.0); 4.2211 (1.9); 4.1933 (1.0); 4.1722 (1.0); 2.5303 (6.0); 2.4099 (16.0); 2.3373 (8.2); 2.0806 (0.3); 1.5896 (14.8); 1.2953 (0.4); 0.0485 (0.4); 0.0378 (13.7); 0.0269 (0.5)
I-775:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0176 (2.7); 7.6071 (0.8); 7.3360 (1.9); 7.3161 (2.2); 7.2632 (15.1); 7.0530 (0.5); 7.0325 (1.9); 7.0235 (1.3); 7.0154 (3.9); 7.0029 (3.8); 6.9874 (0.6); 6.9142 (1.3); 6.8949 (1.2); 6.7628 (0.6); 6.7544 (0.7); 6.7464 (1.2); 6.7404 (1.1); 6.7272 (0.7); 6.7228 (0.7); 4.1908 (0.9); 4.1756 (0.9); 4.1548 (2.0); 4.1397 (2.0); 4.1186 (1.0); 4.1036 (1.0); 3.1055 (6.7); 3.0917 (6.8); 2.9587 (16.0); 2.8855 (15.0); 2.6415 (13.2); 2.4683 (6.7); 2.2674 (9.4); 2.1015 (0.5); 2.0933 (0.6); 2.0804 (1.1); 2.0673 (0.7); 2.0592 (0.6); 2.0459 (0.4); 1.6031 (3.9); 1.0176 (0.6); 1.0058 (1.9); 1.0011 (2.1); 0.9899 (1.1); 0.9846 (2.1); 0.9800 (2.0); 0.9690 (0.9); 0.7674 (0.8); 0.7556 (2.4); 0.7523 (2.4); 0.7431 (2.3); 0.7393 (2.6); 0.7271 (0.8); -0.0002 (1.4)
I-776:1 H-NMR(400.1 MHz, CDCl3): δ= 8.4875 (0.6); 8.0183 (2.9); 7.7654 (1.1); 7.4201 (2.4); 7.3991 (2.8); 7.3703 (3.4); 7.2635 (15.2); 7.1796 (1.9); 7.1585 (1.7); 7.0752 (0.4); 7.0541 (3.2); 7.0400 (4.1); 7.0168 (0.6); 6.7797 (0.8); 6.7664 (1.4); 6.7567 (1.5); 6.7448 (0.9); 6.0433 (0.6); 6.0348 (0.7); 6.0281 (0.7); 6.0204 (0.7); 5.9274 (0.6); 5.9193 (0.7); 5.9127 (0.8); 5.9041 (0.7); 4.1452 (0.3); 4.1247 (0.4); 4.1164 (0.4); 4.1089 (0.4); 4.1007 (0.7); 4.0913 (0.4); 4.0845 (0.4); 4.0765 (0.4); 4.0637 (0.4); 4.0549 (0.4); 4.0479 (0.4); 4.0403 (0.4); 3.8779 (0.3); 3.8630 (0.6); 3.8480 (0.4); 3.8258 (0.6); 3.8176 (0.5); 3.8034 (0.7); 3.7888 (0.4); 3.7823 (0.4); 3.7667 (0.6); 3.7524 (0.3); 3.1731 (0.4); 3.1568 (7.8); 3.1432 (7.8); 2.9594 (16.0); 2.8862 (15.8); 2.6783 (15.2); 2.3820 (0.7); 2.1091 (0.6); 2.0999 (0.8); 2.0882 (1.3); 2.0764 (0.9); 2.0673 (0.8); 2.0542 (0.4); 1.6002 (9.3); 1.0240 (0.7); 1.0077 (2.7); 0.9899 (2.8); 0.9763 (1.1); 0.7743 (0.8); 0.7612 (3.4); 0.7479 (3.4); 0.7344 (1.0); -0.0002 (1.4)
I-777:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9912 (1.0); 7.5633 (0.4); 7.5435 (1.6); 7.5275 (4.4); 7.4064 (2.2); 7.3526 (0.8); 7.3460 (1.3); 7.3404 (1.0); 7.3299 (1.1); 7.2627 (14.3); 6.7145 (3.8); 6.1414 (0.9); 6.1291 (0.6); 3.7943 (1.0); 3.7782 (2.8); 3.7626 (2.9); 3.7466 (1.3); 2.9530 (6.8); 2.8728 (6.6); 2.8666 (2.4); 2.8494 (3.6); 2.8329 (1.9); 2.4125 (16.0); 2.3530 (0.4); 2.3324 (0.8); 2.2914 (12.0); 2.2430 (0.4); 2.1709 (0.4); 2.0445 (12.0); 1.9211 (0.4); 1.5877 (5.0); -0.0002 (1.3)
I-778:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0101 (0.7); 7.5649 (0.6); 7.5459 (1.7); 7.5263 (4.1); 7.4948 (2.9); 7.4585 (1.9); 7.4392 (1.3); 7.4158 (0.4); 7.4120 (0.3); 7.2950 (0.4); 7.2622 (54.2); 6.9981 (0.4); 6.4333 (3.3); 6.2549 (1.0); 6.2337 (1.1); 5.4260 (0.9); 5.4059 (0.9); 5.3951 (0.5); 2.9569 (3.7); 2.8816 (3.5); 2.6060 (0.4); 2.5936 (0.7); 2.5788 (1.8); 2.5615 (1.6); 2.5445 (0.9); 2.5118 (16.0); 2.4611 (0.3); 2.4465 (0.8); 2.4350 (0.4); 2.4248 (0.4); 2.3949 (11.5); 2.3119 (0.7); 2.2632 (0.4); 2.2197 (1.4); 2.1960 (0.7); 2.1742 (0.7); 1.9898 (0.4); 1.9648 (0.7); 1.9559 (0.8); 1.9387 (0.6); 1.9251 (0.7); 1.9029 (0.5); 1.8904 (0.6); 1.8574 (1.1); 1.8438 (1.1); 1.8341 (0.9); 1.8043 (0.5); 1.5776 (15.0); 1.4424 (0.6); 1.4272 (0.6); 1.3946 (0.4); 1.3661 (0.4); 1.3530 (0.4); 1.3258 (0.4); 1.2552 (1.1); 1.2069 (0.4); 1.1860 (0.4); 0.8554 (0.5); -0.0002 (5.0)
I-779:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0107 (1.3); 7.3695 (1.6); 7.3495 (1.8); 7.2629 (11.7); 7.0596 (0.4); 7.0355 (4.5); 7.0218 (2.5); 7.0009 (0.5); 6.9705 (1.2); 6.9504 (1.0); 6.7601 (0.6); 6.7549 (0.7); 6.7433 (1.0); 6.7321 (0.9); 6.7203 (0.5); 6.5594 (0.5); 6.5445 (0.9); 6.5292 (0.5); 4.2517 (0.7); 4.2359 (0.8); 4.2147 (1.6); 4.1989 (1.6); 4.1776 (0.9); 4.1618 (0.8); 3.9620 (13.0); 2.9563 (8.2); 2.8818 (7.8); 2.4837 (16.0); 2.2972 (7.8); 2.0776 (0.5); 2.0691 (0.5); 2.0565 (1.0); 2.0438 (0.6); 2.0354 (0.6); 1.5979 (1.6); 1.0045 (0.5); 0.9926 (1.6); 0.9880 (1.8); 0.9767 (1.1); 0.9715 (1.8); 0.9669 (1.8); 0.9559 (0.8); 0.7536 (0.7); 0.7417 (2.1); 0.7384 (2.1); 0.7293 (2.0); 0.7254 (2.3); 0.7133 (0.8); -0.0002 (1.1)
I-780:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2823 (11.9); 7.9799 (0.8); 7.9613 (1.3); 7.9441 (0.8); 7.5394 (1.0); 7.5299 (1.1); 7.5176 (2.2); 7.5062 (2.0); 7.4991 (1.1); 7.4856 (1.3); 7.3800 (3.5); 7.3534 (4.0); 7.2989 (14.1); 7.2811 (0.7); 7.2627 (4.7); 7.2562 (3.8); 7.2504 (3.4); 7.2377 (6.1); 7.2231 (0.4); 7.2129 (0.4); 7.0600 (3.8); 6.9707 (2.1); 6.9426 (3.7); 6.9051 (2.2); 6.8834 (2.2); 6.8460 (2.3); 5.9512 (3.7); 5.9490 (3.8); 5.8922 (3.4); 5.8899 (3.4); 5.5278 (3.8); 5.5257 (3.7); 5.4904 (3.5); 5.4883 (3.6); 5.3376 (5.5); 4.3051 (2.0); 4.2851 (2.0); 4.2576 (4.3); 4.2377 (4.1); 4.2101 (2.1); 4.1902 (2.1); 2.5170 (6.2); 2.5100 (11.7); 2.5026 (6.5); 2.3270 (0.3); 2.3008 (16.0); 1.5938 (8.4); 1.2946 (1.1); 0.0497 (0.6); 0.0388 (17.3); 0.0279 (0.6)
I-781:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9200 (5.7); 7.8814 (0.4); 7.8632 (0.7); 7.8449 (0.4); 7.7006 (1.9); 7.6954 (1.4); 7.6833 (3.6); 7.5528 (1.6); 7.5127 (0.7); 7.5042 (0.6); 7.4988 (1.0); 7.4926 (0.9); 7.4826 (0.6); 7.4742 (0.4); 7.3813 (1.7); 7.3547 (1.9); 7.2987 (10.3); 7.0813 (1.9); 6.9924 (1.0); 6.9663 (0.9); 4.3465 (0.6); 4.3265 (0.9); 4.3067 (0.5); 4.2982 (1.0); 4.2781 (1.8); 4.2583 (0.9); 4.2498 (0.5); 4.2296 (1.0); 4.2100 (0.6); 3.0111 (16.0); 2.5168 (5.6); 2.5096 (3.1); 2.3229 (7.7); 2.0447 (1.5); 1.6133 (11.2); 1.2905 (0.6); 0.1068 (0.6); 0.0475 (0.4); 0.0366 (10.3); 0.0256 (0.3)
I-782:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 9.3240 (0.3); 9.2647 (5.0); 8.0375 (0.3); 7.5370 (14.7); 7.4703 (0.7); 7.4340 (10.8); 7.4172 (13.7); 7.3196 (9.4); 7.3166 (8.8); 7.3028 (7.1); 7.2998 (6.5); 7.0686 (0.4); 7.0510 (0.4); 7.0342 (0.4); 6.9628 (4.0); 6.9469 (9.0); 6.9310 (6.7); 6.9008 (5.8); 6.8865 (7.8); 6.8713 (3.5); 6.7276 (4.8); 6.7144 (7.7); 6.7006 (4.1); 5.7828 (3.1); 5.6890 (3.1); 5.6570 (0.4); 4.2011 (0.4); 3.9929 (0.3); 3.9603 (0.3); 3.9395 (0.4); 3.9304 (0.4); 3.9260 (0.4); 3.9127 (0.4); 3.9062 (0.4); 3.8959 (0.3); 3.8738 (0.3); 3.8021 (0.4); 3.7884 (0.5); 3.7560 (0.5); 3.7429 (0.5); 3.6915 (1.8); 3.6821 (1.7); 3.6633 (3.0); 3.6539 (2.6); 3.6398 (2.0); 3.6119 (4.2); 3.6024 (4.5); 3.5890 (2.7); 3.5725 (3.2); 3.5602 (3.6); 3.5468 (2.4); 3.5311 (1.7); 3.5190 (1.1); 3.4776 (0.4); 2.4048 (24.4); 2.0027 (1.6); 1.9922 (3.5); 1.9856 (4.3); 1.9759 (6.5); 1.9659 (4.6); 1.9594 (3.9); 1.9490 (2.1); 1.8916 (0.4); 1.2596 (0.8); 1.2491 (0.6); 1.2351 (0.4); 1.1371 (1.2); 1.0852 (0.4); 1.0778 (0.4); 0.9353 (4.6); 0.9264 (12.6); 0.9227 (13.5); 0.9099 (13.3); 0.9061 (13.0); 0.8980 (5.6); 0.8682 (0.7); 0.7559 (0.4); 0.7407 (0.4); 0.7019 (0.6); 0.6716 (5.7); 0.6603 (16.0); 0.6531 (15.6); 0.6504 (15.3); 0.6411 (5.3); -0.0002 (0.9); -0.0339 (0.4); -0.0836 (0.4)
I-783:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4531 (2.0); 7.4251 (2.6); 7.4093 (2.5); 7.2986 (2.5); 7.2307 (1.6); 7.2242 (1.5); 7.2029 (1.3); 7.1963 (1.2); 7.0901 (3.0); 7.0742 (2.2); 7.0708 (2.2); 7.0655 (2.8); 7.0475 (0.4); 6.9136 (0.8); 6.8305 (0.7); 6.8182 (0.7); 6.8095 (1.1); 6.7986 (1.1); 6.7868 (0.7); 6.7768 (0.6); 6.0668 (0.5); 6.0569 (0.5); 6.0437 (0.6); 6.0338 (0.5); 5.9118 (0.5); 5.9018 (0.5); 5.8887 (0.6); 5.8786 (0.5); 4.1695 (0.3); 4.1593 (0.4); 4.1483 (0.4); 4.1231 (16.0); 4.0802 (0.4); 4.0701 (0.4); 4.0590 (0.4); 4.0490 (0.3); 3.9182 (0.5); 3.8959 (0.4); 3.8666 (0.6); 3.8461 (0.6); 3.8227 (0.4); 3.8176 (0.3); 3.7938 (0.4); 2.1184 (0.5); 2.1074 (0.6); 2.0903 (1.1); 2.0731 (0.7); 2.0621 (0.6); 2.0447 (0.3); 1.2912 (0.4); 1.0589 (0.7); 1.0433 (2.0); 1.0367 (2.2); 1.0219 (1.3); 1.0149 (2.1); 1.0086 (2.0); 0.9939 (0.9); 0.8990 (0.3); 0.8779 (0.4); 0.7973 (0.9); 0.7820 (2.4); 0.7770 (2.3); 0.7654 (2.2); 0.7599 (2.5); 0.7435 (0.7); 0.0358 (1.7)
I-784:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3722 (0.8); 7.3651 (1.1); 7.3601 (1.9); 7.3507 (0.9); 7.3462 (1.1); 7.3401 (1.5); 7.3334 (2.2); 7.3278 (1.1); 7.3180 (0.9); 7.2989 (1.2); 7.2187 (0.4); 7.2121 (0.5); 7.1912 (1.6); 7.1846 (1.1); 7.1727 (1.9); 7.1685 (2.8); 7.1638 (1.4); 7.1455 (1.3); 7.1414 (1.4); 7.1179 (0.4); 7.1141 (0.5); 7.0708 (1.9); 6.9777 (1.0); 6.9512 (0.9); 6.8647 (0.5); 6.8439 (1.0); 6.8233 (0.5); 5.3307 (0.4); 4.2481 (0.8); 4.2270 (0.8); 4.1999 (1.7); 4.1788 (1.6); 4.1516 (0.9); 4.1306 (0.8); 3.1936 (0.6); 2.5119 (5.6); 2.3565 (0.5); 2.3323 (16.0); 2.3206 (8.1); 1.7043 (1.2); 1.3062 (0.3); 0.9208 (0.4); 0.0397 (1.2)
I-785:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5516 (0.6); 7.5360 (2.3); 7.5217 (6.8); 7.5190 (3.6); 7.5101 (0.6); 7.5076 (0.7); 7.5030 (0.4); 7.4542 (0.4); 7.4469 (13.1); 7.4428 (3.7); 7.4246 (1.4); 7.4199 (2.3); 7.4156 (1.2); 7.4117 (0.9); 7.4100 (0.9); 7.4063 (1.5); 7.4018 (0.9); 7.3703 (3.4); 7.3544 (3.7); 7.2589 (18.4); 7.0649 (3.4); 6.9872 (1.6); 6.9713 (1.4); 4.7408 (2.8); 4.7385 (3.6); 4.7366 (3.6); 4.7344 (3.0); 4.6531 (0.9); 4.6254 (1.7); 4.5927 (4.6); 4.5885 (4.3); 2.5176 (0.4); 2.4899 (9.5); 2.4487 (0.4); 2.3274 (14.5); 2.3101 (0.6); 1.9308 (0.8); 1.9138 (0.6); 1.9127 (0.6); 1.8575 (16.0); 1.5410 (16.7); 1.2549 (0.4); 0.0700 (2.3); 0.0063 (0.7); -0.0002 (21.5); -0.0068 (0.9)
I-786:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3819 (0.8); 7.3750 (1.2); 7.3698 (2.0); 7.3603 (1.0); 7.3558 (1.2); 7.3508 (1.4); 7.3494 (1.4); 7.3426 (2.2); 7.3369 (1.1); 7.3277 (1.0); 7.2987 (2.8); 7.2335 (0.4); 7.2269 (0.6); 7.2059 (1.6); 7.1994 (1.1); 7.1872 (1.8); 7.1817 (2.6); 7.1584 (1.3); 7.1542 (1.4); 7.1308 (0.4); 7.1267 (0.5); 6.9527 (2.0); 6.8656 (1.1); 6.8385 (1.0); 6.5955 (0.5); 6.5751 (0.9); 6.5545 (0.5); 5.3349 (0.6); 4.2666 (0.8); 4.2456 (0.8); 4.2185 (1.8); 4.1975 (1.7); 4.1703 (0.9); 4.1493 (0.8); 3.2140 (0.9); 2.5211 (5.8); 2.5146 (3.4); 2.4170 (0.4); 2.3614 (16.0); 2.0739 (0.3); 1.8925 (0.5); 1.8812 (0.6); 1.8647 (1.0); 1.8480 (0.6); 1.8368 (0.6); 1.6368 (1.9); 1.3035 (0.4); 1.2923 (0.4); 1.0492 (0.8); 1.0340 (1.9); 1.0271 (2.1); 1.0215 (1.1); 1.0122 (1.2); 1.0056 (2.0); 0.9991 (1.8); 0.9844 (0.9); 0.7344 (1.0); 0.7192 (2.3); 0.7132 (2.1); 0.7027 (1.9); 0.6969 (2.4); 0.6807 (0.7); 0.0383 (3.5)
I-787:1 H-NMR(300.2 MHz, CDCl3): δ= 7.2989 (1.0); 7.1167 (0.4); 7.0891 (1.8); 7.0807 (1.3); 7.0684 (3.5); 7.0598 (2.7); 7.0524 (1.5); 7.0341 (2.2); 7.0255 (0.4); 6.9805 (0.3); 6.9662 (1.8); 6.8670 (1.1); 6.8400 (1.4); 6.8277 (0.7); 6.8187 (1.0); 6.8096 (0.9); 6.7930 (0.6); 6.7860 (0.5); 6.5084 (0.4); 6.4891 (0.8); 6.4697 (0.4); 3.7706 (0.8); 3.7475 (2.2); 3.7271 (2.2); 3.7043 (0.9); 2.9552 (1.5); 2.9321 (2.9); 2.9089 (1.3); 2.4054 (16.0); 2.3229 (10.7); 2.2715 (9.7); 2.2374 (0.5); 2.1851 (0.4); 2.1100 (0.5); 2.0989 (0.5); 2.0816 (0.9); 2.0704 (0.3); 2.0643 (0.5); 2.0535 (0.5); 1.7234 (0.8); 1.0634 (0.7); 1.0481 (1.7); 1.0413 (1.8); 1.0353 (1.0); 1.0266 (1.0); 1.0195 (1.8); 1.0129 (1.6); 0.9984 (0.8); 0.8060 (0.9); 0.7911 (2.0); 0.7849 (2.0); 0.7740 (1.8); 0.7684 (2.1); 0.7520 (0.6); 0.0454 (1.1)
I-788:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5123 (1.0); 7.4832 (2.6); 7.4555 (2.3); 7.3851 (0.6); 7.3775 (0.8); 7.3631 (0.9); 7.3602 (1.0); 7.3521 (1.2); 7.3443 (0.7); 7.3308 (0.9); 7.2986 (4.3); 7.2119 (0.5); 7.1921 (1.6); 7.1783 (4.2); 7.1649 (1.4); 7.1580 (1.9); 7.1284 (0.4); 7.0142 (1.2); 6.9874 (1.1); 6.8087 (0.5); 6.7878 (1.0); 6.7668 (0.5); 5.3307 (2.0); 4.4551 (0.9); 4.4338 (0.8); 4.4076 (1.9); 4.3863 (1.8); 4.3602 (1.0); 4.3388 (0.9); 3.4191 (1.3); 3.3692 (2.6); 3.3192 (1.3); 2.3894 (4.8); 2.3647 (16.0); 2.3339 (8.7); 0.0349 (1.9)
I-789:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4246 (1.8); 7.3965 (2.3); 7.3904 (0.9); 7.3817 (0.8); 7.3682 (1.0); 7.3661 (1.0); 7.3573 (1.0); 7.3523 (1.2); 7.3357 (0.9); 7.3004 (1.2); 7.2986 (2.2); 7.2640 (1.9); 7.2119 (0.4); 7.1929 (1.7); 7.1843 (3.0); 7.1822 (3.1); 7.1656 (2.2); 7.1633 (2.3); 7.1455 (1.2); 7.1176 (0.9); 6.7570 (0.5); 6.7361 (1.0); 6.7155 (0.5); 5.3340 (0.6); 4.2637 (0.9); 4.2425 (0.8); 4.2157 (1.8); 4.1944 (1.8); 4.1676 (0.9); 4.1464 (0.9); 3.2087 (0.4); 2.5513 (6.1); 2.3529 (16.0); 1.6470 (1.2); 1.3029 (0.9); 1.2946 (0.9); 0.9180 (1.0); 0.8949 (0.4); 0.0382 (1.3); 0.0364 (2.7)
I-790:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3972 (1.1); 7.3884 (2.0); 7.3704 (2.8); 7.3619 (2.3); 7.3436 (2.0); 7.2992 (8.6); 7.2916 (1.5); 7.2877 (1.6); 7.2852 (1.7); 7.2817 (1.6); 7.2584 (1.0); 7.2550 (0.9); 7.2235 (1.5); 7.2165 (2.5); 7.2099 (1.4); 7.1314 (1.2); 7.1282 (1.4); 7.1241 (1.3); 7.1209 (1.2); 7.0970 (3.2); 7.0172 (1.2); 6.9914 (1.0); 6.4983 (0.5); 6.4776 (0.9); 6.4584 (0.5); 4.2780 (1.0); 4.2570 (0.9); 4.2294 (2.0); 4.2085 (2.0); 4.1809 (1.0); 4.1598 (1.0); 2.5290 (6.4); 2.3727 (16.0); 2.3468 (8.8); 2.3211 (0.5); 1.5923 (5.2); 1.3029 (0.7); 0.9205 (0.6); 0.1085 (0.3); 0.0494 (0.4); 0.0386 (10.9)
I-791:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2936 (9.3); 7.9845 (1.2); 7.5459 (1.0); 7.5372 (1.2); 7.5232 (1.9); 7.5139 (1.5); 7.5089 (1.8); 7.4919 (1.2); 7.4689 (3.3); 7.4402 (4.8); 7.4316 (4.0); 7.4275 (3.1); 7.2995 (10.9); 7.2821 (2.5); 7.2718 (4.6); 7.2540 (7.0); 7.2288 (2.2); 7.2228 (2.1); 6.9442 (1.7); 6.9068 (1.8); 6.8851 (1.9); 6.8477 (2.0); 6.1449 (0.8); 6.1341 (0.9); 6.1227 (0.9); 6.1120 (0.9); 5.9902 (0.8); 5.9798 (0.9); 5.9682 (1.0); 5.9512 (3.9); 5.8921 (3.3); 5.5295 (3.6); 5.4921 (3.4); 5.3383 (16.0); 4.3361 (0.4); 4.3254 (0.5); 4.3145 (0.5); 4.3036 (0.5); 4.2873 (0.6); 4.2765 (0.6); 4.2656 (0.6); 4.2519 (0.7); 4.2400 (0.5); 4.2290 (0.5); 4.2180 (0.5); 4.2020 (0.6); 4.1913 (0.6); 4.1801 (0.6); 4.1694 (0.6); 3.9620 (0.6); 3.9402 (0.7); 3.9218 (0.6); 3.9132 (0.5); 3.8873 (0.8); 3.8689 (0.8); 3.8466 (0.6); 3.8381 (0.5); 3.8161 (0.6); 3.7976 (0.4); 1.5932 (6.1); 1.2929 (0.4); 0.1086 (0.5); 0.0490 (0.5); 0.0383 (13.2); 0.0276 (0.6)
I-792:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.1395 (0.6); 9.1197 (1.4); 9.1003 (0.6); 8.0795 (6.6); 7.9586 (1.4); 7.9328 (1.7); 7.8139 (1.7); 7.8073 (2.4); 7.8014 (1.7); 7.7579 (2.7); 7.7006 (1.3); 7.6740 (2.6); 7.6480 (1.6); 7.5650 (1.4); 7.5599 (1.3); 7.5575 (1.3); 7.5382 (0.9); 7.5330 (1.0); 7.5197 (0.4); 7.4912 (6.4); 6.0885 (0.4); 6.0710 (0.9); 6.0549 (0.5); 5.9345 (0.4); 5.9175 (1.0); 5.9013 (0.5); 5.7776 (1.7); 3.9326 (0.8); 3.9141 (1.2); 3.8957 (0.7); 3.8553 (0.8); 3.8370 (1.3); 3.8191 (0.7); 3.3423 (16.0); 2.6313 (15.8); 2.5340 (1.8); 2.5283 (3.9); 2.5224 (5.4); 2.5165 (4.0); 0.0200 (3.3)
I-793:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0907 (0.5); 8.3097 (0.4); 7.7748 (2.3); 7.7262 (0.6); 7.7066 (0.5); 7.6815 (0.6); 7.6195 (0.8); 7.5626 (0.4); 7.3180 (0.7); 7.2980 (0.8); 7.0696 (0.7); 6.9361 (0.4); 6.9151 (0.4); 4.2476 (0.4); 4.1239 (0.4); 4.1133 (0.3); 4.1102 (0.4); 4.1031 (0.4); 4.0923 (0.6); 4.0771 (0.6); 4.0554 (0.4); 4.0401 (0.4); 3.3282 (88.3); 3.2411 (0.4); 2.6719 (0.4); 2.5423 (4.5); 2.5254 (1.0); 2.5207 (1.6); 2.5121 (22.8); 2.5076 (46.7); 2.5030 (61.5); 2.4984 (44.6); 2.4938 (21.7); 2.4197 (2.1); 2.3298 (0.4); 2.2199 (2.9); 2.0723 (1.4); 1.3907 (16.0); 1.3729 (1.0); -0.0002 (2.9)
I-794:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 10.8023 (0.3); 9.3200 (1.2); 9.3041 (2.2); 9.2891 (1.1); 9.0821 (9.2); 8.9856 (0.5); 8.3101 (10.8); 7.7368 (1.1); 7.7175 (2.9); 7.6976 (2.5); 7.6694 (3.1); 7.6486 (1.7); 7.6115 (0.6); 7.5719 (3.8); 7.5453 (2.3); 7.5263 (1.9); 7.3291 (3.6); 7.3089 (4.1); 7.2811 (0.5); 7.2742 (0.5); 7.2603 (0.5); 7.2518 (0.4); 7.1391 (0.5); 7.0996 (4.4); 6.9733 (2.1); 6.9527 (2.0); 5.8056 (0.5); 5.7869 (1.0); 5.7673 (0.5); 4.6146 (1.0); 4.5961 (1.6); 4.5773 (0.9); 4.4239 (0.4); 4.4150 (0.4); 4.2064 (0.4); 4.1799 (1.1); 4.1642 (1.3); 4.1420 (2.4); 4.1271 (2.5); 4.1064 (1.6); 4.0897 (1.5); 4.0572 (0.5); 4.0398 (1.2); 4.0272 (1.2); 4.0192 (2.1); 4.0064 (2.1); 3.9982 (1.4); 3.9861 (1.3); 3.8817 (0.8); 3.8551 (2.2); 3.8336 (3.3); 3.8151 (2.8); 3.7954 (0.9); 3.7813 (1.8); 3.7624 (3.4); 3.7416 (3.2); 3.7224 (1.8); 3.6998 (3.2); 3.6848 (3.2); 3.6785 (2.8); 3.6630 (2.7); 3.6465 (1.2); 3.6301 (1.1); 3.4562 (1.7); 3.3298 (3319.8); 3.2420 (0.6); 3.1478 (0.5); 3.1306 (1.1); 3.1093 (1.3); 3.0915 (1.0); 3.0750 (0.4); 2.7123 (0.7); 2.6808 (4.0); 2.6762 (8.4); 2.6717 (11.9); 2.6672 (8.8); 2.6628 (4.4); 2.6514 (0.6); 2.5420 (117.9); 2.5252 (36.7); 2.5205 (54.3); 2.5117 (693.4); 2.5073 (1414.5); 2.5028 (1866.6); 2.4982 (1375.8); 2.4938 (692.3); 2.4395 (11.8); 2.3674 (2.0); 2.3341 (8.2); 2.3296 (11.6); 2.3251 (8.8); 2.2890 (3.2); 2.2484 (16.0); 2.2204 (1.9); 2.2092 (1.6); 2.1994 (1.8); 2.1883 (1.1); 2.1795 (0.8); 2.1721 (1.9); 2.0724 (2.5); 2.0489 (0.6); 2.0313 (1.2); 2.0116 (1.3); 2.0001 (1.2); 1.9826 (1.0); 1.9626 (0.6); 1.9141 (0.4); 1.9019 (0.4); 1.5812 (0.4); 1.4675 (0.5); 1.4513 (0.5); 1.4421 (0.5); 1.4331 (0.4); 1.4199 (0.5); 1.4040 (0.5); 1.3821 (0.8); 1.3679 (0.6); 1.3425 (1.1); 1.2355 (0.7); 1.2008 (0.4); 1.1812 (0.6); 1.0572 (0.4); 0.0079 (1.4); -0.0002 (54.2); -0.0084 (2.1)
I-795:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3286 (0.3); 9.1070 (1.2); 9.0915 (2.5); 9.0755 (1.2); 8.3106 (1.2); 7.8534 (12.3); 7.7438 (1.1); 7.7242 (3.3); 7.7045 (2.9); 7.6787 (3.3); 7.6584 (1.7); 7.6232 (4.0); 7.5911 (0.6); 7.5608 (2.3); 7.5421 (1.8); 7.3302 (0.6); 7.3151 (3.9); 7.2952 (4.2); 7.0977 (0.6); 7.0701 (4.1); 6.9187 (2.2); 6.8987 (2.0); 4.4380 (1.3); 4.1283 (1.3); 4.1124 (1.3); 4.0911 (2.8); 4.0752 (2.7); 4.0537 (1.4); 4.0379 (1.3); 3.5104 (0.4); 3.5017 (0.6); 3.4941 (0.6); 3.4887 (0.7); 3.4833 (0.4); 3.4472 (0.4); 3.4410 (0.7); 3.4360 (0.6); 3.4281 (0.7); 3.4197 (0.5); 3.3984 (0.4); 3.3895 (0.4); 3.3324 (402.1); 3.2823 (0.4); 3.2558 (1.8); 3.2513 (0.8); 3.2409 (0.8); 3.2371 (0.6); 3.2286 (0.7); 3.2186 (5.4); 3.2115 (0.8); 3.2025 (0.5); 3.1916 (3.2); 3.1726 (4.2); 3.1671 (2.8); 3.1523 (3.8); 2.8386 (0.6); 2.8240 (0.4); 2.8106 (2.0); 2.7960 (1.4); 2.7901 (2.0); 2.7867 (1.8); 2.7825 (2.2); 2.7710 (1.8); 2.7679 (1.8); 2.7620 (2.0); 2.7585 (1.6); 2.7547 (1.0); 2.7428 (1.7); 2.7337 (0.7); 2.7143 (0.6); 2.6808 (0.4); 2.6766 (0.9); 2.6720 (1.3); 2.6675 (1.0); 2.6630 (0.5); 2.5423 (8.9); 2.5255 (4.1); 2.5208 (6.1); 2.5121 (73.4); 2.5077 (149.9); 2.5031 (198.0); 2.4985 (144.0); 2.4939 (70.5); 2.4183 (11.6); 2.3391 (0.4); 2.3345 (0.9); 2.3299 (1.2); 2.3253 (0.9); 2.3208 (0.4); 2.2466 (2.2); 2.2195 (16.0); 2.0726 (1.2); -0.0002 (7.8)
I-796:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0927 (0.5); 9.0771 (0.9); 9.0615 (0.4); 8.3098 (0.4); 7.7392 (0.5); 7.7196 (1.2); 7.6995 (1.2); 7.6940 (4.8); 7.6724 (1.2); 7.6532 (0.7); 7.6290 (1.5); 7.5626 (0.9); 7.5424 (0.7); 7.3104 (1.5); 7.2904 (1.7); 7.0687 (1.6); 6.9202 (0.8); 6.9008 (0.8); 4.1252 (0.5); 4.1091 (0.5); 4.0879 (1.1); 4.0722 (1.0); 4.0507 (0.5); 4.0353 (0.5); 3.7168 (1.6); 3.7009 (3.4); 3.6852 (1.6); 3.3315 (81.4); 3.2673 (0.7); 3.2637 (0.8); 3.2509 (0.6); 3.2426 (1.3); 3.2370 (16.0); 3.2106 (0.5); 3.1425 (1.4); 3.1268 (2.9); 3.1109 (1.3); 2.6722 (0.4); 2.5425 (12.1); 2.5256 (1.1); 2.5208 (1.6); 2.5121 (21.2); 2.5077 (42.8); 2.5032 (56.2); 2.4986 (41.2); 2.4941 (20.4); 2.4181 (4.5); 2.3298 (0.4); 2.2461 (0.5); 2.2221 (6.3); -0.0002 (2.7)
I-797:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 20.0078 (1.5); 9.0381 (2.2); 8.3104 (13.2); 7.7133 (2.7); 7.6941 (2.8); 7.6715 (3.1); 7.6338 (11.5); 7.6244 (4.0); 7.5575 (2.2); 7.5379 (1.8); 7.3466 (1.1); 7.3277 (4.9); 7.3114 (16.0); 7.2665 (4.6); 7.2463 (5.6); 7.0427 (4.0); 6.8704 (2.2); 6.8507 (2.0); 5.7858 (1.0); 4.5958 (1.7); 4.2538 (11.6); 4.0551 (2.7); 4.0400 (2.7); 3.3280 (3955.0); 3.2555 (3.8); 2.6761 (11.4); 2.6715 (15.6); 2.6670 (11.6); 2.5419 (48.2); 2.5250 (48.3); 2.5202 (72.0); 2.5116 (896.2); 2.5071 (1806.4); 2.5026 (2365.1); 2.4980 (1722.7); 2.4935 (848.8); 2.3883 (10.7); 2.3339 (10.6); 2.3294 (14.6); 2.3248 (10.9); 2.2868 (1.5); 2.2096 (14.8); 2.1642 (1.5); 2.0725 (2.6); 1.3424 (1.9); 1.2348 (2.5); 0.1392 (3.0); 0.0080 (4.1); -0.0002 (107.1); -0.0085 (3.1); -0.0242 (1.0)
I-798:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.0736 (1.1); 9.0580 (2.3); 9.0424 (1.1); 8.3108 (1.4); 7.7336 (1.0); 7.7140 (3.0); 7.6943 (2.6); 7.6667 (4.8); 7.6483 (1.6); 7.6101 (3.9); 7.5941 (10.3); 7.5501 (2.2); 7.5304 (1.7); 7.3083 (3.4); 7.2884 (3.7); 7.0685 (4.1); 6.9200 (2.2); 6.9002 (2.0); 5.7876 (0.5); 5.0531 (0.4); 5.0103 (0.4); 5.0030 (0.4); 4.9774 (0.3); 4.6152 (0.3); 4.5965 (0.6); 4.1203 (1.1); 4.1048 (1.2); 4.0834 (2.6); 4.0676 (2.5); 4.0463 (1.3); 4.0307 (1.2); 3.3304 (409.6); 3.2690 (0.4); 3.2128 (0.6); 3.2087 (0.3); 2.9930 (5.6); 2.9740 (6.3); 2.9120 (0.5); 2.8928 (0.7); 2.8737 (0.5); 2.7052 (0.6); 2.6857 (1.5); 2.6763 (1.3); 2.6717 (1.9); 2.6669 (3.1); 2.6472 (1.5); 2.6277 (0.6); 2.5421 (3.5); 2.5253 (4.6); 2.5205 (6.9); 2.5118 (94.2); 2.5074 (193.2); 2.5029 (256.5); 2.4983 (188.9); 2.4938 (94.8); 2.4153 (11.2); 2.3388 (0.6); 2.3342 (1.2); 2.3296 (1.7); 2.3252 (1.2); 2.3210 (0.6); 2.2477 (0.5); 2.2204 (16.0); 2.0831 (0.5); 2.0725 (0.5); 2.0650 (0.6); 2.0252 (0.6); 2.0070 (1.3); 1.9982 (1.4); 1.9912 (1.9); 1.9864 (1.8); 1.9786 (1.4); 1.9713 (1.7); 1.9560 (0.7); 1.9509 (0.7); 1.8721 (0.6); 1.8674 (0.5); 1.8475 (1.7); 1.8340 (2.6); 1.8272 (2.0); 1.8135 (2.3); 1.7985 (1.4); 1.7880 (0.6); 1.7696 (1.4); 1.7507 (1.9); 1.7465 (2.0); 1.7219 (2.2); 1.7017 (1.5); 0.0080 (0.4); -0.0002 (12.3); -0.0084 (0.5)
I-799:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8991 (1.3); 7.8895 (1.3); 7.6259 (0.4); 7.5999 (1.8); 7.5804 (4.5); 7.5778 (4.7); 7.4799 (2.4); 7.4578 (0.4); 7.4408 (1.0); 7.4312 (1.5); 7.4240 (1.2); 7.4081 (2.9); 7.3811 (2.4); 7.2996 (6.6); 7.0921 (2.6); 7.0128 (1.4); 6.9864 (1.3); 6.5109 (0.6); 6.4898 (1.3); 6.4698 (0.7); 4.3155 (1.0); 4.2946 (1.0); 4.2670 (2.1); 4.2462 (2.1); 4.2186 (1.1); 4.1977 (1.1); 2.9496 (0.5); 2.9371 (0.8); 2.9256 (1.2); 2.9131 (1.2); 2.9012 (0.8); 2.8892 (0.6); 2.6912 (16.0); 2.6624 (0.4); 2.5379 (7.5); 2.3590 (0.5); 2.3225 (9.9); 2.2380 (0.4); 1.6269 (5.2); 1.2918 (3.2); 0.9169 (1.1); 0.8934 (3.2); 0.8747 (2.9); 0.8702 (2.7); 0.8516 (1.1); 0.6436 (0.9); 0.6266 (2.4); 0.6199 (2.5); 0.6139 (2.4); 0.6098 (2.3); 0.5902 (0.7); 0.1079 (5.5); 0.0371 (7.0)
I-800:1 H-NMR(300.2 MHz, CDCl3): δ= 9.2572 (1.0); 7.7910 (0.6); 7.7636 (0.8); 7.7475 (0.6); 7.7194 (0.7); 7.5093 (11.1); 7.4942 (8.8); 7.4570 (7.6); 7.4467 (8.3); 7.4104 (3.3); 7.2992 (18.0); 7.2760 (3.7); 7.2701 (3.4); 7.2214 (0.7); 7.2026 (0.7); 7.1508 (0.4); 6.8284 (0.5); 6.8180 (0.5); 6.7987 (0.5); 6.2333 (1.3); 6.2146 (1.3); 6.0757 (1.3); 6.0576 (1.4); 4.6385 (0.6); 4.6253 (0.7); 4.5883 (0.8); 4.5782 (0.8); 4.5370 (0.7); 4.5250 (0.7); 4.4883 (0.8); 4.4776 (0.8); 4.1507 (0.8); 4.1285 (1.0); 4.1105 (1.2); 4.0969 (1.2); 4.0678 (1.0); 4.0402 (0.7); 4.0224 (0.5); 3.9117 (0.4); 3.8980 (0.4); 3.8541 (3.9); 2.7236 (0.4); 2.7155 (0.4); 2.6539 (1.4); 2.6287 (1.1); 2.5313 (13.0); 2.4708 (1.3); 2.4313 (1.4); 2.3998 (1.0); 2.3885 (1.2); 2.3543 (1.2); 2.3127 (0.7); 2.2875 (0.7); 2.2782 (0.7); 2.1860 (16.0); 1.9718 (0.3); 1.9167 (0.4); 1.8941 (0.3); 1.4604 (0.5); 1.4034 (1.0); 1.3735 (1.0); 1.2919 (11.9); 1.1952 (0.8); 1.1724 (0.8); 1.1482 (0.7); 1.0577 (0.3); 0.9176 (1.2); 0.8923 (1.2); 0.8670 (1.1); 0.1079 (12.6); 0.0374 (14.6)
I-801:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8534 (0.4); 7.6108 (0.7); 7.5899 (2.0); 7.4909 (1.0); 7.4542 (0.4); 7.4457 (0.7); 7.4386 (0.4); 7.4233 (0.5); 7.4106 (1.0); 7.3838 (1.0); 7.2996 (7.8); 7.0935 (1.1); 7.0159 (0.6); 6.9885 (0.5); 6.3494 (0.5); 4.3246 (0.4); 4.3035 (0.4); 4.2763 (0.9); 4.2554 (0.9); 4.2278 (0.5); 4.2071 (0.5); 3.4515 (0.6); 3.4286 (1.2); 3.4063 (1.2); 3.3846 (0.6); 2.6986 (7.3); 2.5411 (3.2); 2.3238 (4.2); 1.6777 (0.6); 1.6534 (1.2); 1.6295 (1.3); 1.6035 (16.0); 1.2921 (0.4); 1.0201 (1.9); 0.9956 (3.8); 0.9708 (1.7); 0.1075 (0.9); 0.0377 (8.2)
I-802:1 H-NMR(600.1 MHz, CDCl3): δ= 8.1678 (9.0); 7.9688 (0.8); 7.9597 (1.5); 7.9504 (0.8); 7.6407 (0.7); 7.6276 (2.6); 7.6158 (7.4); 7.6057 (0.6); 7.6042 (0.6); 7.4790 (3.6); 7.4453 (0.4); 7.4349 (1.3); 7.4312 (2.4); 7.4277 (1.4); 7.4243 (1.0); 7.4199 (1.8); 7.4163 (1.1); 7.3280 (3.5); 7.3147 (3.8); 7.2615 (13.8); 7.0328 (4.0); 6.9377 (2.1); 6.9244 (2.0); 4.4510 (0.8); 4.2461 (1.5); 4.2362 (1.5); 4.2221 (3.4); 4.2122 (3.3); 4.1980 (1.7); 4.1882 (1.6); 4.0989 (2.8); 3.4455 (1.6); 3.2241 (4.1); 3.2147 (6.9); 3.2053 (3.9); 3.1927 (0.3); 2.7323 (0.9); 2.5000 (0.9); 2.4746 (11.2); 2.3007 (1.0); 2.2938 (0.5); 2.2764 (16.0); 2.2652 (0.6); 1.6111 (2.0); 1.4271 (0.4); 1.3337 (1.3); 1.2847 (1.8); 1.2561 (1.8); 0.8813 (0.5); 0.8694 (0.3); -0.0001 (2.6)
I-803:1 H-NMR(600.1 MHz, CDCl3): δ= 8.1675 (9.3); 7.9564 (0.8); 7.9471 (1.5); 7.9377 (0.8); 7.6199 (0.6); 7.6068 (2.5); 7.5956 (7.0); 7.5861 (0.5); 7.5845 (0.6); 7.4671 (3.3); 7.4244 (1.2); 7.4204 (2.2); 7.4167 (1.4); 7.4143 (0.9); 7.4127 (0.9); 7.4094 (1.6); 7.4057 (0.9); 7.3269 (3.3); 7.3136 (3.5); 7.2615 (14.5); 7.0303 (3.7); 6.9339 (2.0); 6.9206 (1.8); 4.2430 (1.4); 4.2332 (1.3); 4.2190 (3.1); 4.2092 (3.0); 4.1950 (1.5); 4.1852 (1.4); 4.1328 (2.3); 4.1209 (7.0); 4.1090 (7.0); 4.0971 (2.3); 3.3003 (3.4); 3.2883 (7.6); 3.2763 (3.9); 2.9154 (4.0); 2.9034 (8.0); 2.8914 (3.6); 2.4737 (10.2); 2.2748 (14.9); 1.5808 (9.6); 1.3337 (1.2); 1.2849 (1.6); 1.2554 (2.1); 1.2395 (8.1); 1.2276 (16.0); 1.2157 (7.8); 0.8806 (0.5); 0.8688 (0.3); 0.8444 (0.4); 0.8408 (0.4); -0.0001 (2.8)
I-804:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3197 (0.5); 9.3045 (1.0); 9.2892 (0.5); 7.9531 (0.5); 7.6815 (0.6); 7.6621 (1.3); 7.6424 (1.0); 7.6108 (1.2); 7.5912 (0.6); 7.4651 (1.6); 7.4501 (1.0); 7.4304 (0.7); 7.2847 (1.4); 7.2780 (0.4); 7.2647 (1.6); 7.0583 (1.9); 6.8780 (0.9); 6.8566 (1.2); 6.8407 (1.1); 6.8254 (0.5); 4.1040 (0.4); 4.0888 (0.4); 4.0658 (0.9); 4.0504 (0.8); 4.0273 (0.5); 4.0115 (0.5); 3.4301 (0.6); 3.4141 (1.4); 3.3963 (1.4); 3.3802 (0.6); 3.3299 (34.9); 2.8905 (4.0); 2.7318 (3.3); 2.7312 (3.3); 2.7165 (1.4); 2.6985 (2.1); 2.6817 (1.2); 2.5627 (2.5); 2.5249 (0.5); 2.5201 (0.7); 2.5113 (10.1); 2.5069 (20.7); 2.5023 (27.3); 2.4978 (19.7); 2.4933 (9.6); 2.3918 (4.6); 2.2145 (6.2); 2.2039 (1.3); 2.0612 (16.0); 1.2392 (1.0); -0.0002 (2.6)
I-805:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3451 (0.5); 9.3292 (1.1); 9.3233 (1.2); 9.3076 (2.2); 9.2921 (1.0); 7.9530 (2.1); 7.6846 (1.2); 7.6648 (3.3); 7.6452 (2.7); 7.6137 (3.4); 7.5939 (1.7); 7.4785 (3.5); 7.4587 (2.4); 7.4390 (1.9); 7.2910 (3.1); 7.2710 (3.5); 7.0659 (4.4); 6.9066 (0.8); 6.8915 (2.0); 6.8729 (1.6); 6.7698 (0.4); 6.7555 (0.9); 6.7404 (0.4); 6.4927 (0.9); 6.4788 (2.0); 6.4646 (1.0); 5.0690 (0.4); 5.0570 (1.6); 5.0449 (1.6); 5.0330 (0.4); 4.9771 (0.9); 4.9652 (3.6); 4.9532 (3.6); 4.9412 (1.0); 4.4027 (0.4); 4.3920 (0.5); 4.3839 (0.5); 4.3734 (0.4); 4.3490 (0.4); 4.3370 (0.9); 4.3241 (1.2); 4.3205 (1.2); 4.3069 (1.1); 4.2954 (0.4); 4.1009 (0.9); 4.0853 (1.0); 4.0715 (1.5); 4.0625 (2.0); 4.0551 (2.0); 4.0501 (2.4); 4.0339 (1.3); 4.0242 (1.3); 4.0083 (1.0); 3.9879 (0.4); 3.8638 (1.5); 3.8460 (1.9); 3.8424 (2.7); 3.8248 (2.0); 3.7679 (2.1); 3.7568 (2.0); 3.7465 (1.5); 3.7354 (1.4); 3.4761 (0.8); 3.4607 (0.8); 3.4547 (0.8); 3.4392 (0.8); 3.4160 (0.6); 3.4008 (0.9); 3.3907 (0.6); 3.3812 (1.7); 3.3688 (2.0); 3.3553 (2.0); 3.3391 (3.4); 3.3295 (99.4); 3.3056 (1.2); 3.2910 (0.6); 2.8903 (16.0); 2.7319 (13.0); 2.7308 (13.6); 2.6712 (0.4); 2.6666 (0.3); 2.5247 (1.1); 2.5200 (1.6); 2.5113 (26.1); 2.5068 (54.9); 2.5022 (73.7); 2.4976 (53.4); 2.4931 (25.7); 2.3927 (12.4); 2.3337 (0.4); 2.3290 (0.5); 2.3245 (0.4); 2.2753 (0.4); 2.2187 (13.6); 1.3231 (12.8); 1.3111 (12.8); 1.2615 (6.2); 1.2495 (6.5); 1.2391 (2.1); 0.8534 (0.6); -0.0002 (7.5)
I-806:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3303 (1.2); 9.3150 (2.6); 9.2995 (1.3); 9.2552 (0.5); 7.9531 (1.5); 7.7273 (0.6); 7.7072 (0.6); 7.6911 (0.7); 7.6769 (1.4); 7.6575 (3.5); 7.6376 (2.8); 7.6066 (3.5); 7.5864 (1.8); 7.5766 (0.8); 7.5475 (0.4); 7.5271 (0.4); 7.4895 (4.1); 7.4709 (0.4); 7.4583 (2.3); 7.4390 (1.9); 7.3291 (0.6); 7.3089 (0.8); 7.2955 (3.6); 7.2755 (4.0); 7.2607 (0.4); 7.0628 (4.6); 6.8940 (2.6); 6.8741 (2.5); 6.5059 (2.6); 6.4817 (2.7); 5.9975 (1.2); 5.9835 (1.2); 5.9716 (1.3); 5.9573 (1.6); 5.9546 (1.6); 5.9403 (1.4); 5.9284 (1.4); 5.9144 (1.4); 5.5468 (0.4); 5.5423 (0.4); 5.1278 (3.3); 5.0815 (4.0); 5.0794 (4.1); 5.0529 (3.2); 4.4688 (0.7); 4.4530 (1.0); 4.4443 (0.8); 4.4389 (0.9); 4.4295 (1.0); 4.4146 (0.6); 4.1085 (0.8); 4.0994 (0.8); 4.0929 (0.8); 4.0688 (1.1); 4.0524 (1.0); 4.0312 (1.0); 4.0152 (0.9); 3.9946 (1.0); 3.9801 (1.0); 3.9556 (0.7); 3.9402 (0.7); 3.3593 (0.4); 3.3333 (170.3); 2.8906 (11.4); 2.7315 (9.9); 2.6714 (0.4); 2.6673 (0.3); 2.5249 (1.2); 2.5115 (27.1); 2.5071 (55.6); 2.5026 (73.7); 2.4981 (53.4); 2.4937 (26.0); 2.4097 (2.3); 2.3938 (11.5); 2.3339 (0.3); 2.3294 (0.5); 2.3251 (0.4); 2.2195 (16.0); 2.2095 (4.6); 2.0101 (0.4); 1.9910 (0.3); 1.6639 (0.8); 1.6519 (0.7); 1.2971 (11.0); 1.2808 (10.9); 1.2389 (2.3); 0.8533 (0.7); 0.8350 (0.4); -0.0002 (6.7)
I-807:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3075 (1.2); 9.2921 (2.7); 9.2766 (1.3); 7.6815 (1.2); 7.6618 (3.2); 7.6420 (2.6); 7.6106 (3.2); 7.5911 (1.6); 7.4796 (4.1); 7.4566 (2.4); 7.4368 (1.8); 7.2924 (3.7); 7.2723 (4.2); 7.0636 (4.3); 6.8940 (2.2); 6.8740 (2.0); 6.5587 (1.3); 6.5443 (2.7); 6.5300 (1.3); 4.1016 (1.0); 4.0863 (1.1); 4.0633 (2.3); 4.0478 (2.2); 4.0249 (1.2); 4.0098 (1.2); 3.5000 (2.8); 3.4860 (7.3); 3.4728 (4.6); 3.3821 (2.1); 3.3686 (5.0); 3.3547 (4.4); 3.3303 (80.8); 3.2705 (45.4); 2.8903 (0.8); 2.7308 (0.7); 2.6711 (0.4); 2.5248 (0.8); 2.5200 (1.3); 2.5113 (21.1); 2.5068 (43.7); 2.5023 (57.9); 2.4976 (41.6); 2.4931 (19.9); 2.3944 (11.3); 2.3291 (0.4); 2.2206 (16.0); 1.2581 (0.6); 1.2392 (2.1); 0.8530 (0.6); -0.0002 (5.6)
I-808:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2652 (0.4); 9.2498 (0.9); 9.2343 (0.4); 7.7487 (0.4); 7.7292 (1.1); 7.7097 (1.0); 7.6894 (1.2); 7.6696 (0.5); 7.5459 (1.5); 7.5352 (0.9); 7.5151 (0.6); 7.3142 (1.3); 7.2942 (1.4); 7.0642 (1.5); 6.8765 (0.8); 6.8565 (0.7); 4.1683 (0.4); 4.1531 (0.4); 4.1311 (0.8); 4.1156 (0.8); 4.0934 (0.4); 4.0781 (0.4); 3.5572 (1.6); 3.5422 (3.5); 3.5274 (1.9); 3.3344 (42.1); 3.2573 (1.8); 3.2426 (3.4); 3.2274 (2.0); 3.2225 (16.0); 2.8907 (0.7); 2.7312 (0.6); 2.5252 (0.4); 2.5204 (0.5); 2.5117 (7.3); 2.5073 (14.9); 2.5027 (19.6); 2.4981 (13.9); 2.4936 (6.6); 2.4088 (3.9); 2.2032 (5.6); 1.2392 (0.4); -0.0002 (2.2)
I-809:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2826 (1.3); 9.2671 (2.8); 9.2515 (1.3); 7.9532 (1.1); 7.6754 (1.2); 7.6558 (3.3); 7.6360 (2.6); 7.6030 (3.2); 7.5834 (1.7); 7.4741 (4.2); 7.4506 (2.4); 7.4309 (1.8); 7.2960 (3.8); 7.2760 (4.2); 7.0611 (4.3); 6.9000 (2.2); 6.8800 (2.0); 6.7211 (1.3); 6.7061 (2.7); 6.6911 (1.3); 4.0967 (1.0); 4.0818 (1.0); 4.0585 (2.3); 4.0431 (2.2); 4.0198 (1.2); 4.0044 (1.1); 3.3358 (155.7); 3.3197 (2.0); 3.3034 (3.5); 3.2839 (3.4); 3.2683 (1.6); 2.8907 (8.6); 2.7322 (6.9); 2.7313 (6.9); 2.6718 (0.4); 2.5253 (1.1); 2.5205 (1.7); 2.5119 (22.8); 2.5074 (46.6); 2.5028 (61.2); 2.4982 (43.3); 2.4937 (20.2); 2.3936 (11.2); 2.3296 (0.4); 2.2209 (16.0); 1.4994 (1.6); 1.4818 (3.8); 1.4637 (3.8); 1.4463 (1.6); 1.2391 (1.0); 0.6591 (0.4); 0.6461 (0.8); 0.6398 (0.8); 0.6281 (1.4); 0.6205 (0.8); 0.6155 (0.8); 0.6085 (1.0); 0.5965 (0.5); 0.5910 (0.4); 0.4191 (1.6); 0.4090 (4.2); 0.4047 (4.5); 0.3992 (2.0); 0.3949 (2.2); 0.3888 (4.1); 0.3847 (3.8); 0.3750 (1.4); 0.0637 (1.5); 0.0535 (4.6); 0.0501 (5.0); 0.0414 (4.5); 0.0379 (4.6); 0.0274 (1.2); -0.0002 (3.4)
I-810:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2694 (1.2); 9.2540 (2.7); 9.2385 (1.2); 9.0838 (0.6); 7.9529 (1.7); 7.7466 (1.0); 7.7271 (3.1); 7.7076 (3.1); 7.6916 (3.5); 7.6724 (1.5); 7.6536 (0.7); 7.6328 (0.6); 7.5994 (0.8); 7.5761 (4.2); 7.5474 (2.3); 7.5279 (1.8); 7.4040 (1.2); 7.3985 (1.1); 7.3925 (0.9); 7.3290 (3.7); 7.3091 (4.1); 7.2563 (0.9); 7.2364 (1.0); 7.1197 (1.3); 7.0678 (4.2); 7.0130 (1.0); 6.8918 (2.2); 6.8724 (2.0); 6.7571 (0.6); 6.7367 (0.5); 4.1519 (1.1); 4.1368 (1.1); 4.1149 (2.4); 4.0994 (2.4); 4.0775 (1.4); 4.0618 (1.4); 3.3303 (117.9); 2.8906 (13.6); 2.7311 (11.2); 2.6762 (0.3); 2.6714 (0.5); 2.6669 (0.4); 2.5249 (1.3); 2.5201 (1.9); 2.5115 (28.3); 2.5070 (58.8); 2.5024 (78.4); 2.4978 (56.5); 2.4933 (27.2); 2.4101 (11.1); 2.3754 (2.8); 2.3338 (0.4); 2.3292 (0.5); 2.3246 (0.4); 2.2082 (16.0); 2.1726 (4.1); 2.0101 (0.4); 1.9905 (0.4); 1.3758 (5.5); 1.2394 (2.3); 0.9374 (0.4); 0.9213 (1.3); 0.9092 (0.4); 0.8534 (0.8); 0.8354 (0.3); 0.6241 (0.4); 0.6117 (1.4); 0.6074 (1.4); 0.5947 (0.4); -0.0002 (6.9)
I-811:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.3275 (1.2); 9.3121 (2.7); 9.2966 (1.3); 7.7662 (1.0); 7.7467 (3.2); 7.7272 (3.1); 7.7117 (3.6); 7.6920 (1.4); 7.5901 (4.1); 7.5686 (2.4); 7.5488 (1.8); 7.3232 (3.8); 7.3032 (4.2); 7.0711 (4.2); 6.8887 (2.2); 6.8693 (2.0); 4.1845 (1.1); 4.1688 (1.1); 4.1472 (2.4); 4.1316 (2.4); 4.1144 (2.0); 4.0898 (4.9); 4.0644 (4.8); 4.0390 (1.7); 3.3297 (88.3); 2.8906 (1.6); 2.7311 (1.4); 2.6714 (0.4); 2.5249 (0.9); 2.5202 (1.4); 2.5115 (23.2); 2.5070 (47.7); 2.5024 (63.0); 2.4978 (44.8); 2.4932 (21.1); 2.4151 (11.2); 2.3292 (0.4); 2.2064 (16.0); 1.2582 (0.5); 1.2393 (1.8); 0.8534 (0.6); -0.0002 (6.2)
I-812:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1373 (0.8); 9.1206 (1.4); 9.1023 (1.3); 9.0859 (0.5); 7.9530 (2.0); 7.6878 (0.5); 7.6791 (0.6); 7.6683 (1.5); 7.6606 (1.5); 7.6488 (1.2); 7.6394 (1.2); 7.6067 (2.1); 7.5869 (1.1); 7.4617 (1.8); 7.4574 (2.0); 7.4270 (5.1); 7.4094 (1.2); 7.2677 (3.1); 7.2477 (3.4); 7.0891 (1.8); 7.0833 (1.9); 7.0294 (3.4); 6.8122 (1.0); 6.7959 (1.8); 6.7784 (1.2); 6.6366 (1.2); 6.6289 (1.2); 4.2005 (0.3); 4.1796 (0.4); 4.1630 (0.3); 4.0972 (0.3); 4.0643 (0.6); 4.0278 (0.4); 4.0112 (0.4); 3.9396 (0.4); 3.9276 (0.4); 3.9025 (0.4); 3.8902 (0.4); 3.3564 (0.4); 3.3337 (127.1); 2.8905 (16.0); 2.7322 (13.0); 2.7310 (13.6); 2.7177 (0.8); 2.7102 (0.7); 2.7005 (0.4); 2.6716 (0.4); 2.5250 (1.0); 2.5203 (1.6); 2.5116 (23.7); 2.5072 (49.0); 2.5026 (64.8); 2.4980 (46.3); 2.4934 (21.9); 2.4636 (0.4); 2.4552 (0.8); 2.4471 (1.1); 2.4388 (1.1); 2.4308 (0.9); 2.4224 (0.4); 2.3795 (9.2); 2.3340 (0.3); 2.3294 (0.4); 2.1931 (8.0); 2.1868 (10.4); 1.2928 (0.3); 1.2766 (0.6); 1.2688 (0.8); 1.2574 (1.0); 1.2495 (0.8); 1.2400 (1.3); 1.0330 (0.4); 1.0221 (0.5); 1.0167 (0.5); 1.0108 (0.5); 1.0056 (0.4); 1.0002 (0.5); 0.9134 (0.5); 0.9015 (0.6); 0.8929 (1.1); 0.8807 (1.2); 0.8687 (0.9); 0.8597 (1.1); 0.8523 (0.6); 0.8476 (0.8); 0.8366 (0.5); 0.8265 (0.4); 0.6977 (0.4); 0.6827 (0.6); 0.6790 (0.6); 0.6637 (0.6); 0.6564 (0.5); 0.6419 (0.3); 0.6086 (0.6); 0.5990 (0.7); 0.5949 (0.8); 0.5851 (1.2); 0.5754 (0.7); 0.5713 (0.7); 0.5618 (0.6); 0.5012 (0.4); 0.4852 (0.7); 0.4757 (0.7); 0.4603 (0.4); 0.4498 (0.9); 0.4331 (1.6); 0.4268 (1.2); 0.4174 (1.7); 0.4025 (1.7); 0.3940 (0.9); 0.3905 (0.8); 0.3824 (1.2); 0.3738 (0.5); 0.3698 (0.6); 0.3619 (0.5); 0.3213 (0.5); 0.3127 (0.6); 0.3094 (0.6); 0.3006 (1.2); 0.2890 (0.9); 0.2796 (0.9); 0.2698 (0.7); 0.2659 (0.8); 0.2558 (0.5); 0.2457 (0.7); 0.2230 (0.3); 0.1302 (0.5); 0.1180 (1.8); 0.1071 (2.3); 0.1013 (1.5); 0.0983 (1.6); 0.0944 (1.5); 0.0856 (1.3); 0.0813 (0.8); 0.0737 (1.2); 0.0621 (1.2); 0.0527 (1.2); 0.0398 (0.8); 0.0297 (0.5); -0.0002 (6.0)
I-813:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1451 (1.1); 9.1295 (2.4); 9.1141 (1.2); 7.9524 (0.5); 7.8986 (15.0); 7.3328 (3.8); 7.3128 (4.4); 7.0904 (7.6); 7.0844 (4.7); 6.9946 (2.2); 6.9748 (2.0); 6.9253 (2.1); 6.9189 (1.9); 6.9039 (3.0); 6.8975 (2.9); 6.8186 (6.8); 6.7972 (4.6); 4.5992 (3.6); 4.5775 (7.7); 4.5557 (3.9); 4.1104 (1.2); 4.0946 (1.2); 4.0731 (2.8); 4.0573 (2.7); 4.0356 (1.4); 4.0200 (1.3); 3.3286 (51.8); 3.2374 (2.5); 3.2158 (5.0); 3.1941 (2.4); 2.8896 (4.1); 2.7313 (3.3); 2.7303 (3.4); 2.6706 (0.4); 2.5241 (1.0); 2.5194 (1.4); 2.5107 (21.6); 2.5062 (44.8); 2.5016 (58.9); 2.4970 (41.6); 2.4924 (19.5); 2.4188 (11.1); 2.3285 (0.4); 2.2637 (0.7); 2.2504 (16.0); 2.1999 (0.3); 1.2391 (1.3); 0.8533 (0.4); -0.0002 (5.0)
I-814:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1928 (1.1); 9.1772 (2.4); 9.1616 (1.2); 7.9417 (15.7); 7.4715 (2.5); 7.4519 (5.2); 7.4323 (3.4); 7.3201 (3.9); 7.3002 (4.4); 7.2487 (2.8); 7.2296 (2.4); 7.1809 (2.5); 7.1762 (4.0); 7.1724 (3.1); 7.1486 (2.4); 7.1446 (1.7); 7.1303 (2.0); 7.1286 (2.0); 7.1244 (1.6); 7.0817 (4.0); 6.9576 (2.1); 6.9376 (2.0); 4.4604 (15.8); 4.1138 (1.2); 4.0982 (1.2); 4.0769 (2.8); 4.0611 (2.7); 4.0397 (1.4); 4.0239 (1.3); 3.3287 (49.6); 3.3221 (51.8); 2.8896 (1.6); 2.7315 (1.2); 2.7302 (1.3); 2.6706 (0.4); 2.5242 (1.0); 2.5195 (1.4); 2.5108 (21.6); 2.5063 (44.9); 2.5017 (59.2); 2.4970 (41.6); 2.4924 (19.4); 2.4149 (11.1); 2.3284 (0.4); 2.2588 (0.5); 2.2328 (16.0); 2.1876 (0.3); 1.2387 (0.5); -0.0002 (6.2)
I-815:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2948 (1.1); 9.2791 (2.4); 9.2636 (1.2); 8.0705 (12.9); 7.9535 (1.6); 7.9497 (1.6); 7.9393 (1.4); 7.9344 (2.3); 7.9300 (1.7); 7.9196 (1.5); 7.9158 (1.5); 7.8298 (1.3); 7.8259 (1.3); 7.8095 (2.6); 7.8061 (2.4); 7.7897 (1.6); 7.7859 (1.4); 7.5670 (2.0); 7.5473 (3.5); 7.5266 (1.6); 7.3243 (3.8); 7.3043 (4.2); 7.0701 (4.1); 6.9341 (2.2); 6.9142 (2.0); 4.1354 (1.2); 4.1199 (1.2); 4.0986 (2.7); 4.0829 (2.6); 4.0615 (1.4); 4.0459 (1.3); 3.3295 (50.8); 2.8909 (3.1); 2.7312 (2.6); 2.6717 (0.4); 2.5253 (1.1); 2.5206 (1.6); 2.5118 (23.8); 2.5074 (49.0); 2.5028 (64.4); 2.4982 (45.7); 2.4937 (21.6); 2.4446 (0.4); 2.4206 (11.1); 2.3296 (0.4); 2.3056 (0.4); 2.2030 (16.0); 1.2386 (0.5); -0.0002 (6.0)
I-816:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2515 (1.1); 9.2362 (2.4); 9.2204 (1.1); 7.9787 (13.5); 7.9533 (0.6); 7.3265 (3.8); 7.3065 (4.2); 7.2731 (0.7); 7.2608 (1.6); 7.2500 (1.8); 7.2385 (1.4); 7.2333 (1.3); 7.2133 (1.1); 7.2024 (0.5); 7.1934 (8.0); 7.1810 (4.3); 7.1586 (0.5); 7.0735 (4.2); 6.9484 (2.2); 6.9282 (2.0); 4.1195 (1.2); 4.1039 (1.2); 4.0826 (2.7); 4.0669 (2.6); 4.0455 (1.4); 4.0298 (1.3); 3.3289 (54.6); 2.8903 (4.9); 2.7315 (4.2); 2.6710 (0.4); 2.5245 (1.3); 2.5197 (2.0); 2.5111 (26.1); 2.5067 (52.2); 2.5021 (67.2); 2.4975 (47.1); 2.4930 (22.0); 2.4199 (11.2); 2.3334 (0.4); 2.3287 (0.6); 2.3244 (0.4); 2.2973 (13.2); 2.2933 (13.1); 2.2659 (0.4); 2.2083 (16.0); 2.1847 (0.4); 1.2392 (1.2); 0.8535 (0.4); -0.0002 (5.4)
I-817:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1767 (0.8); 9.1610 (1.7); 9.1454 (0.8); 7.9321 (10.4); 7.3710 (1.5); 7.3516 (3.3); 7.3323 (2.0); 7.3239 (2.9); 7.3039 (3.2); 7.1239 (2.0); 7.1050 (1.9); 7.1035 (1.9); 7.0847 (3.1); 7.0209 (3.5); 7.0187 (4.2); 7.0173 (4.4); 6.9968 (1.5); 6.9913 (1.1); 6.9648 (1.6); 6.9452 (1.4); 4.1096 (0.9); 4.0939 (0.9); 4.0724 (2.0); 4.0567 (1.9); 4.0350 (1.0); 4.0193 (0.9); 3.3302 (41.6); 2.5243 (0.8); 2.5196 (1.2); 2.5109 (15.7); 2.5064 (32.4); 2.5018 (42.4); 2.4972 (29.7); 2.4926 (13.8); 2.4155 (8.2); 2.3460 (16.0); 2.3286 (0.4); 2.2906 (0.7); 2.2590 (0.4); 2.2378 (11.8); 1.2388 (0.4); -0.0002 (3.9)
I-818:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2533 (1.0); 9.2378 (2.2); 9.2221 (1.0); 7.9996 (16.0); 7.9530 (0.4); 7.3503 (0.4); 7.3448 (0.6); 7.3301 (2.2); 7.3241 (4.5); 7.3205 (6.2); 7.3104 (2.6); 7.3061 (5.8); 7.2982 (4.0); 7.2860 (1.5); 7.2026 (1.5); 7.1970 (1.5); 7.1842 (2.3); 7.1784 (1.2); 7.1742 (1.3); 7.1705 (1.1); 7.1602 (1.0); 7.0677 (3.7); 6.9327 (1.9); 6.9129 (1.7); 4.1220 (1.0); 4.1063 (1.0); 4.0853 (2.4); 4.0695 (2.3); 4.0483 (1.2); 4.0327 (1.1); 3.3279 (49.1); 2.8902 (3.2); 2.7308 (2.6); 2.6711 (0.4); 2.5450 (34.1); 2.5328 (0.5); 2.5247 (1.2); 2.5200 (1.7); 2.5112 (24.2); 2.5067 (50.0); 2.5021 (65.6); 2.4975 (46.0); 2.4929 (21.4); 2.4179 (9.8); 2.3289 (0.4); 2.3243 (0.4); 2.2911 (0.9); 2.2634 (0.4); 2.2036 (14.2); 2.1810 (0.4); 1.2392 (0.9); -0.0002 (5.2)
I-819:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.1928 (1.2); 9.1773 (2.6); 9.1616 (1.4); 8.0040 (15.8); 7.9701 (0.4); 7.6858 (0.6); 7.6779 (5.7); 7.6756 (7.1); 7.6700 (3.1); 7.6666 (3.8); 7.6617 (5.2); 7.6469 (4.5); 7.6447 (4.4); 7.5353 (0.4); 7.5284 (0.5); 7.5239 (2.2); 7.5177 (2.3); 7.5163 (2.4); 7.5089 (2.9); 7.5040 (1.7); 7.5008 (1.8); 7.4949 (1.7); 7.4898 (0.5); 7.4844 (0.5); 7.3143 (3.7); 7.2943 (4.2); 7.0734 (4.1); 7.0422 (0.3); 6.9158 (2.2); 6.8955 (2.1); 4.1288 (1.2); 4.1133 (1.2); 4.0919 (2.8); 4.0761 (2.8); 4.0548 (1.6); 4.0391 (1.5); 3.3275 (51.3); 3.2943 (1.7); 2.8904 (1.2); 2.7308 (1.0); 2.6711 (0.4); 2.6666 (0.3); 2.5246 (1.4); 2.5199 (2.0); 2.5113 (24.4); 2.5067 (51.6); 2.5022 (69.5); 2.4976 (51.2); 2.4931 (26.2); 2.4725 (4.4); 2.4684 (4.7); 2.4130 (11.4); 2.3791 (1.0); 2.3336 (0.4); 2.3289 (0.5); 2.3244 (0.4); 2.2541 (0.4); 2.2173 (16.0); 2.1840 (1.0); 2.1719 (0.6); 1.2397 (0.7); -0.0002 (6.1)
I-820:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 9.2935 (1.1); 9.2777 (2.4); 9.2621 (1.2); 8.0518 (15.6); 7.6121 (0.9); 7.5928 (1.8); 7.5813 (0.8); 7.5780 (1.0); 7.5747 (1.0); 7.5111 (0.7); 7.5062 (1.0); 7.4901 (2.8); 7.4852 (1.9); 7.4759 (3.1); 7.4708 (5.4); 7.4534 (2.2); 7.4500 (2.9); 7.4323 (0.7); 7.4291 (0.9); 7.3218 (3.9); 7.3018 (4.3); 7.0656 (4.1); 6.9185 (2.2); 6.8985 (2.0); 4.1328 (1.2); 4.1171 (1.2); 4.0960 (2.7); 4.0802 (2.6); 4.0591 (1.3); 4.0434 (1.3); 3.3287 (61.2); 3.3153 (0.5); 2.8907 (0.6); 2.7325 (0.6); 2.7312 (0.6); 2.6764 (0.4); 2.6718 (0.5); 2.6673 (0.4); 2.5254 (1.3); 2.5207 (1.8); 2.5120 (28.7); 2.5075 (60.2); 2.5029 (79.2); 2.4982 (55.7); 2.4936 (26.2); 2.4447 (0.3); 2.4203 (11.1); 2.3342 (0.4); 2.3297 (0.5); 2.3250 (0.4); 2.3053 (0.4); 2.2913 (1.0); 2.2622 (0.4); 2.1833 (16.0); 2.1662 (0.5); 1.2393 (0.6); -0.0002 (8.6)
I-821:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2640 (1.3); 9.2483 (2.7); 9.2330 (1.3); 7.9610 (0.8); 7.7298 (1.1); 7.7102 (3.0); 7.6907 (2.5); 7.6633 (3.4); 7.6438 (1.6); 7.5064 (5.2); 7.4831 (2.0); 7.3137 (3.5); 7.2938 (3.9); 7.0828 (4.4); 6.9059 (2.3); 6.8861 (2.1); 4.1787 (1.1); 4.1631 (1.1); 4.1409 (2.4); 4.1255 (2.3); 4.1028 (1.3); 4.0875 (1.2); 3.7048 (5.7); 3.6946 (8.0); 3.6833 (6.2); 3.3106 (88.4); 3.2029 (6.0); 3.1925 (7.8); 3.1817 (5.6); 2.8991 (5.2); 2.7400 (4.6); 2.5134 (17.5); 2.5090 (23.8); 2.5047 (17.7); 2.4199 (11.5); 2.2252 (16.0)
I-822:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5593 (2.7); 7.3842 (0.6); 7.3799 (0.6); 7.3744 (1.4); 7.3633 (2.7); 7.3592 (3.0); 7.3534 (5.8); 7.3338 (2.3); 7.2620 (13.9); 7.2424 (1.2); 7.2141 (1.6); 7.2089 (2.7); 7.2038 (1.5); 7.0938 (1.2); 7.0899 (1.2); 7.0733 (1.1); 7.0695 (1.0); 6.4896 (0.5); 6.4746 (1.0); 6.4600 (0.6); 6.0175 (0.5); 6.0099 (0.6); 6.0000 (0.6); 5.9926 (0.6); 5.9011 (0.5); 5.8936 (0.6); 5.8837 (0.6); 5.8762 (0.6); 4.1748 (0.4); 4.1672 (0.4); 4.1582 (0.4); 4.1505 (0.4); 4.1449 (0.3); 4.1282 (0.3); 4.1079 (0.4); 4.1002 (0.4); 4.0914 (0.4); 4.0835 (0.4); 3.9012 (0.3); 3.8862 (0.5); 3.8691 (0.4); 3.8646 (0.3); 3.8464 (0.6); 3.8314 (0.7); 3.8137 (0.4); 3.8089 (0.4); 3.7916 (0.4); 2.5912 (0.8); 2.3878 (16.0); 1.5618 (12.8); 0.0078 (0.5); -0.0002 (15.9); -0.0080 (1.0)
I-823:1 H-NMR(400.1 MHz, CDCl3): δ= 8.1674 (0.8); 8.1538 (0.6); 8.1263 (5.4); 7.3095 (1.8); 7.2886 (2.2); 7.2613 (10.1); 7.1337 (0.4); 7.1193 (1.4); 7.1134 (2.6); 7.1104 (2.9); 7.0972 (3.3); 7.0765 (0.5); 6.9860 (3.3); 6.9712 (1.6); 6.8454 (0.7); 6.8394 (0.8); 6.8283 (1.2); 6.8170 (1.1); 6.8050 (0.6); 5.9525 (0.5); 5.9451 (0.6); 5.9322 (0.6); 5.9248 (0.6); 5.8336 (0.5); 5.8264 (0.6); 5.8134 (0.6); 5.8060 (0.6); 4.1666 (0.4); 4.1594 (0.4); 4.1496 (0.4); 4.1419 (0.4); 4.1105 (0.3); 4.0915 (0.4); 4.0837 (0.4); 4.0741 (0.4); 4.0666 (0.4); 3.7181 (0.3); 3.7064 (0.3); 3.6978 (0.3); 3.6855 (0.4); 3.6822 (0.4); 3.6721 (0.5); 3.6611 (0.7); 3.6511 (0.5); 3.6400 (0.4); 3.6367 (0.4); 3.6242 (0.3); 2.7170 (16.0); 2.7003 (0.6); 2.3769 (11.4); 2.2759 (10.0); 2.1247 (0.6); 2.1161 (0.7); 2.1034 (1.1); 2.0908 (0.7); 2.0824 (0.7); 2.0691 (0.3); 1.5709 (11.2); 1.0447 (0.6); 1.0331 (2.0); 1.0282 (2.1); 1.0172 (1.1); 1.0118 (2.2); 1.0070 (2.1); 0.9961 (1.0); 0.7945 (0.8); 0.7827 (2.4); 0.7790 (2.4); 0.7704 (2.2); 0.7661 (2.7); 0.7542 (0.8); 0.0078 (0.4); -0.0002 (12.6)
I-824:1 H-NMR(400.1 MHz, CDCl3): δ= 8.3031 (7.4); 7.7128 (1.0); 7.6163 (4.9); 7.6034 (3.7); 7.5823 (0.4); 7.3976 (2.7); 7.3439 (1.0); 7.3374 (1.2); 7.3298 (1.5); 7.3252 (1.3); 7.3152 (0.8); 7.2618 (12.2); 6.6697 (5.0); 3.7816 (1.5); 3.7654 (3.5); 3.7507 (3.6); 3.7345 (1.7); 2.8714 (2.5); 2.8549 (4.8); 2.8384 (2.5); 2.2429 (16.0); 2.0468 (15.9); 1.5656 (9.6); 0.0077 (0.5); -0.0002 (15.0)
I-825:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2883 (15.7); 7.9302 (2.2); 7.9166 (1.4); 7.6655 (0.5); 7.6441 (5.8); 7.6312 (11.1); 7.5155 (5.3); 7.4623 (0.5); 7.4517 (2.0); 7.4421 (2.9); 7.4373 (3.0); 7.4295 (2.4); 7.4231 (1.8); 7.2619 (59.2); 6.9980 (0.3); 6.8755 (16.0); 4.3187 (2.8); 4.3033 (2.8); 4.2829 (5.9); 4.2675 (5.8); 4.2472 (3.1); 4.2318 (2.9); 3.4996 (0.4); 3.4873 (0.4); 1.5556 (79.0); 0.1459 (0.4); 0.0077 (2.7); -0.0002 (73.5); -0.0082 (4.4); -0.1496 (0.4)
I-826:1 H-NMR(400.1 MHz, CDCl3): δ= 8.3068 (8.2); 7.8236 (0.9); 7.6126 (5.1); 7.5998 (4.1); 7.5787 (0.5); 7.4070 (2.9); 7.3860 (1.2); 7.3795 (1.3); 7.3721 (1.6); 7.3673 (1.3); 7.3636 (1.1); 7.3572 (0.8); 7.2623 (14.8); 5.9076 (2.7); 5.9003 (3.0); 5.7056 (2.4); 5.7005 (2.4); 3.8262 (1.6); 3.8113 (3.8); 3.7957 (3.9); 3.7807 (1.9); 2.9354 (2.6); 2.9198 (4.4); 2.9042 (2.6); 2.1309 (0.5); 2.0537 (16.0); 1.5681 (9.6); 0.0077 (0.6); -0.0002 (18.3); -0.0082 (1.1)
I-827:1 H-NMR(499.9 MHz, CDCl3): δ= 8.1881 (0.4); 8.1776 (0.6); 8.1672 (0.4); 8.1009 (5.3); 7.4002 (1.8); 7.3845 (2.0); 7.2594 (5.4); 7.0849 (3.0); 7.0775 (1.6); 7.0755 (1.7); 7.0735 (1.8); 7.0702 (2.4); 7.0593 (0.4); 6.9616 (1.1); 6.9457 (1.0); 6.9309 (2.0); 6.8254 (0.6); 6.8176 (0.5); 6.8132 (0.9); 6.8063 (1.0); 6.7988 (0.5); 6.7932 (0.5); 5.2043 (0.7); 5.1971 (0.8); 5.1888 (0.8); 5.1816 (0.7); 3.9519 (0.6); 3.9446 (0.6); 3.9387 (0.6); 3.9313 (0.6); 3.9240 (0.7); 3.9167 (0.7); 3.9108 (0.7); 3.9034 (0.6); 3.5699 (0.6); 3.5601 (0.7); 3.5544 (0.7); 3.5444 (0.8); 3.5421 (0.7); 3.5322 (0.6); 3.5264 (0.6); 3.5165 (0.6); 2.6975 (16.0); 2.6821 (0.6); 2.5084 (0.4); 2.3593 (0.4); 2.3490 (11.1); 2.3137 (0.4); 2.2474 (10.1); 2.1044 (0.5); 2.0978 (0.5); 2.0942 (0.4); 2.0875 (1.0); 2.0808 (0.4); 2.0771 (0.6); 2.0705 (0.6); 1.6169 (0.3); 1.0312 (0.7); 1.0220 (1.8); 1.0182 (1.9); 1.0143 (1.0); 1.0093 (1.0); 1.0050 (1.9); 1.0012 (1.9); 0.9923 (0.9); 0.7807 (0.9); 0.7717 (2.1); 0.7681 (2.1); 0.7614 (2.0); 0.7579 (2.3); 0.7484 (0.9); -0.0002 (7.0)
I-828:1 H-NMR(400.1 MHz, CDCl3): δ= 8.8551 (0.5); 8.8400 (0.8); 8.8259 (0.5); 8.0806 (5.5); 7.3261 (1.9); 7.3061 (2.0); 7.2613 (12.1); 7.0875 (3.5); 6.9838 (2.1); 6.8512 (1.1); 6.8316 (1.1); 4.2419 (0.8); 4.2261 (0.9); 4.2069 (1.8); 4.1913 (1.8); 4.1719 (1.0); 4.1564 (0.9); 3.8375 (0.5); 3.7345 (16.0); 3.7001 (0.5); 2.9325 (0.8); 2.9136 (2.6); 2.8948 (2.7); 2.8847 (0.5); 2.8772 (1.0); 2.4723 (6.2); 2.3212 (0.3); 2.3054 (0.3); 2.2758 (8.5); 2.2216 (0.3); 1.5651 (5.0); 1.3977 (4.0); 1.3789 (8.2); 1.3600 (4.0); -0.0002 (0.4)
I-829:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2655 (9.4); 8.0167 (2.2); 7.8915 (0.9); 7.8780 (1.5); 7.8644 (1.0); 7.3673 (1.4); 7.3607 (3.8); 7.3518 (3.4); 7.3402 (5.2); 7.3359 (4.5); 7.3184 (2.3); 7.2698 (2.6); 7.2619 (21.3); 7.2508 (3.4); 7.2298 (1.3); 7.0457 (4.0); 6.9913 (2.2); 6.9708 (2.0); 4.2628 (1.6); 4.2478 (1.6); 4.2269 (3.4); 4.2118 (3.4); 4.1909 (1.8); 4.1758 (1.8); 2.9569 (16.0); 2.8836 (14.8); 2.4870 (11.3); 2.4398 (0.4); 2.3118 (0.4); 2.2850 (15.9); 2.1706 (0.4); 1.7542 (1.8); 1.7409 (5.4); 1.7346 (5.8); 1.7222 (2.6); 1.6839 (0.3); 1.5741 (14.2); 1.5280 (0.6); 1.4900 (2.4); 1.4775 (5.7); 1.4711 (6.0); 1.4578 (2.3); -0.0002 (0.7)
I-830:1 H-NMR(400.1 MHz, CDCl3): δ= 8.3589 (1.3); 8.2560 (8.2); 8.0172 (2.2); 7.6923 (2.8); 7.6709 (3.0); 7.3363 (2.5); 7.3164 (2.8); 7.2672 (3.3); 7.2608 (16.4); 7.2550 (2.7); 7.2480 (2.9); 7.2411 (2.1); 7.0217 (3.0); 6.9485 (2.0); 6.9433 (2.0); 6.9272 (3.5); 6.9222 (2.6); 6.9081 (1.6); 6.5884 (2.2); 4.2465 (1.2); 4.2316 (1.2); 4.2103 (2.6); 4.1954 (2.5); 4.1741 (1.4); 4.1591 (1.3); 2.9554 (16.0); 2.8836 (14.5); 2.4698 (8.4); 2.2544 (11.7); 1.5822 (7.5); -0.0002 (0.5)
I-831:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2563 (10.2); 8.0484 (1.4); 8.0348 (0.9); 8.0165 (0.7); 7.4838 (1.6); 7.4639 (3.4); 7.4440 (2.0); 7.3293 (3.5); 7.3094 (3.9); 7.2607 (20.5); 7.1594 (3.9); 7.1548 (3.5); 7.1457 (3.0); 7.1273 (4.2); 7.1247 (4.1); 7.1094 (2.2); 7.1038 (1.8); 7.0335 (4.0); 6.9485 (2.2); 6.9285 (2.0); 4.2441 (1.7); 4.2292 (1.7); 4.2081 (3.6); 4.1932 (3.6); 4.1721 (1.9); 4.1572 (1.8); 2.9564 (4.2); 2.8836 (3.8); 2.4715 (11.3); 2.4469 (0.7); 2.3288 (0.6); 2.2858 (16.0); 1.5927 (1.1); 1.5764 (4.2); 1.5723 (5.4); 1.5634 (12.1); 1.5479 (2.2); 1.5289 (3.4); 1.5253 (3.4); 1.5102 (1.3); 1.1504 (0.9); 1.1346 (3.1); 1.1307 (3.8); 1.1127 (3.8); 1.1090 (3.2); 1.0929 (0.9); -0.0002 (0.7)
I-832:1 H-NMR(400.1 MHz, CDCl3): δ= 8.2585 (10.6); 8.0161 (0.7); 7.8401 (0.8); 7.8271 (1.4); 7.3403 (3.4); 7.3204 (3.9); 7.2944 (0.5); 7.2789 (1.0); 7.2610 (24.7); 7.2432 (6.3); 7.2371 (3.4); 7.2268 (4.2); 7.2239 (3.8); 7.2152 (1.8); 7.2057 (1.0); 7.1972 (0.7); 7.0341 (4.0); 6.9544 (2.2); 6.9344 (2.0); 6.7779 (2.3); 6.5962 (4.7); 6.4145 (2.4); 4.2539 (1.8); 4.2389 (1.7); 4.2181 (3.8); 4.2031 (3.7); 4.1823 (2.0); 4.1673 (1.9); 2.9566 (5.4); 2.8835 (4.9); 2.4744 (11.5); 2.2767 (16.0); 1.5626 (16.6); 1.2539 (0.3); -0.0002 (0.7)
I-833:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0085 (0.9); 7.4881 (0.9); 7.4848 (0.9); 7.4691 (1.5); 7.4529 (0.9); 7.3408 (2.3); 7.3208 (2.5); 7.2593 (32.9); 7.2413 (0.9); 7.2208 (1.7); 7.2035 (1.1); 7.1080 (1.2); 7.0876 (1.8); 7.0669 (0.8); 6.9204 (2.8); 6.8330 (1.5); 6.8112 (1.4); 6.3560 (0.6); 6.3417 (1.1); 4.2371 (1.1); 4.2209 (1.0); 4.2009 (2.2); 4.1853 (2.2); 4.1648 (1.1); 4.1494 (1.1); 2.9531 (5.7); 2.8790 (5.4); 2.4921 (7.7); 2.3525 (16.0); 1.8509 (0.7); 1.8423 (0.7); 1.8302 (1.2); 1.8182 (0.8); 1.8094 (0.6); 1.5469 (40.4); 1.0032 (0.8); 0.9910 (2.3); 0.9863 (2.4); 0.9701 (2.3); 0.9655 (2.2); 0.9545 (0.9); 0.6931 (0.9); 0.6808 (3.0); 0.6647 (2.9); 0.6523 (0.8); -0.0002 (33.7)
I-834:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5593 (4.2); 7.3855 (0.6); 7.3614 (7.7); 7.3339 (2.8); 7.3296 (2.7); 7.3120 (1.9); 7.2667 (16.6); 7.2621 (17.0); 7.2265 (2.9); 7.2119 (5.0); 7.2081 (6.5); 7.0936 (2.3); 7.0743 (2.0); 7.0707 (2.0); 6.3833 (1.6); 6.3695 (1.0); 6.0169 (0.9); 6.0021 (0.9); 5.9018 (0.9); 5.8853 (0.9); 4.2190 (0.4); 4.2046 (0.4); 4.1825 (0.6); 4.1771 (0.5); 4.1654 (0.6); 4.1600 (0.6); 4.1543 (0.5); 4.1463 (0.4); 4.1343 (0.4); 4.1173 (0.5); 4.1096 (0.5); 4.1053 (0.5); 4.0998 (0.5); 3.8847 (0.4); 3.8713 (0.7); 3.8523 (0.7); 3.8334 (0.9); 3.8157 (1.0); 3.7972 (0.8); 3.7788 (0.7); 3.7656 (0.4); 2.6140 (14.8); 2.6101 (15.7); 2.5963 (1.3); 2.2966 (15.2); 2.2926 (16.0); 1.5665 (14.6); 0.0044 (20.9); -0.0002 (21.7)
I-835:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0124 (1.6); 7.3736 (2.3); 7.3538 (2.6); 7.2598 (12.9); 7.1811 (2.8); 7.0761 (0.5); 7.0617 (1.8); 7.0535 (3.1); 7.0407 (3.8); 7.0232 (1.8); 7.0052 (1.5); 6.7808 (0.8); 6.7748 (0.9); 6.7637 (1.3); 6.7526 (1.2); 6.7405 (0.6); 6.4478 (0.6); 6.4329 (1.0); 6.4191 (0.6); 6.0609 (0.6); 6.0531 (0.6); 6.0444 (0.6); 6.0358 (0.6); 5.9444 (0.6); 5.9365 (0.6); 5.9272 (0.6); 5.9192 (0.6); 4.2177 (0.3); 4.2009 (0.3); 4.1897 (0.4); 4.1814 (0.4); 4.1731 (0.4); 4.1640 (0.5); 4.1524 (0.3); 4.1448 (0.3); 4.1361 (0.3); 4.1246 (0.4); 4.1161 (0.4); 4.1080 (0.4); 4.0997 (0.4); 3.9257 (0.4); 3.9114 (0.5); 3.8945 (0.4); 3.8897 (0.4); 3.8720 (0.7); 3.8577 (0.8); 3.8404 (0.4); 3.8355 (0.4); 3.8209 (0.4); 2.9526 (11.6); 2.8800 (10.8); 2.6145 (0.5); 2.5943 (15.8); 2.3432 (0.4); 2.3113 (16.0); 2.2938 (12.0); 2.0839 (0.6); 2.0756 (0.7); 2.0627 (1.2); 2.0498 (0.7); 2.0417 (0.7); 2.0283 (0.4); 1.5632 (8.6); 1.0081 (0.8); 0.9964 (2.2); 0.9916 (2.4); 0.9804 (1.3); 0.9752 (2.3); 0.9705 (2.3); 0.9595 (0.9); 0.7643 (1.0); 0.7526 (2.8); 0.7492 (2.7); 0.7402 (2.5); 0.7363 (2.8); 0.7240 (0.8); -0.0002 (17.5)
I-836:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0117 (1.5); 7.2923 (2.2); 7.2728 (2.7); 7.2592 (14.9); 7.0851 (0.7); 7.0694 (1.6); 7.0651 (1.5); 7.0541 (3.6); 7.0482 (2.1); 7.0359 (2.6); 7.0142 (2.2); 6.9916 (2.0); 6.9819 (2.8); 6.7741 (1.0); 6.7702 (1.0); 6.7565 (1.4); 6.7513 (1.5); 6.7412 (0.8); 6.7344 (0.7); 6.5362 (0.6); 6.5213 (0.9); 5.9287 (0.6); 5.9213 (0.6); 5.9083 (0.6); 5.9005 (0.5); 5.8096 (0.6); 5.8022 (0.6); 5.7892 (0.6); 5.7819 (0.6); 4.1760 (0.3); 4.1505 (0.3); 4.1396 (0.4); 4.1317 (0.4); 4.1220 (0.4); 4.1143 (0.4); 4.1012 (0.3); 4.0831 (0.3); 4.0755 (0.3); 4.0649 (0.4); 4.0571 (0.4); 4.0469 (0.4); 4.0389 (0.4); 3.7304 (0.6); 3.7180 (0.4); 3.7102 (0.4); 3.6970 (0.5); 3.6862 (0.5); 3.6817 (0.4); 3.6738 (0.7); 3.6658 (0.4); 3.6530 (0.5); 3.6374 (0.3); 3.1676 (1.0); 2.9521 (10.8); 2.9224 (0.4); 2.8797 (10.1); 2.6033 (16.0); 2.5772 (1.3); 2.3719 (12.4); 2.3479 (1.6); 2.3372 (15.7); 2.3192 (2.1); 2.3112 (1.2); 2.2914 (12.0); 2.2313 (1.1); 2.0908 (0.5); 2.0781 (0.8); 2.0692 (0.8); 2.0568 (1.3); 2.0440 (0.8); 2.0359 (0.7); 2.0229 (0.4); 1.5691 (3.2); 1.0008 (0.8); 0.9891 (2.6); 0.9843 (2.6); 0.9731 (1.6); 0.9679 (2.6); 0.9632 (2.4); 0.9523 (1.0); 0.7570 (1.0); 0.7455 (3.1); 0.7330 (2.8); 0.7290 (3.0); 0.7168 (0.9); -0.0002 (19.8)
I-837:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0122 (1.7); 7.3616 (2.4); 7.3415 (2.6); 7.2597 (14.0); 7.0783 (0.5); 7.0634 (2.1); 7.0546 (6.2); 7.0412 (3.4); 7.0204 (0.6); 6.9169 (1.7); 6.9133 (1.6); 6.8969 (1.5); 6.8933 (1.4); 6.7815 (0.8); 6.7756 (0.9); 6.7644 (1.3); 6.7530 (1.1); 6.7411 (0.6); 6.4433 (0.6); 6.4293 (1.0); 6.4152 (0.6); 6.0450 (0.6); 6.0369 (0.7); 6.0275 (0.6); 6.0192 (0.6); 5.9286 (0.6); 5.9202 (0.7); 5.9113 (0.7); 5.9031 (0.6); 4.2141 (0.3); 4.2052 (0.3); 4.1972 (0.3); 4.1856 (0.4); 4.1774 (0.4); 4.1694 (0.4); 4.1602 (0.5); 4.1489 (0.3); 4.1207 (0.4); 4.1120 (0.4); 4.1040 (0.4); 4.0955 (0.4); 3.9077 (0.4); 3.8914 (0.5); 3.8765 (0.4); 3.8716 (0.4); 3.8539 (0.7); 3.8398 (0.8); 3.8222 (0.4); 3.8174 (0.4); 3.8029 (0.4); 2.9524 (12.5); 2.8799 (11.6); 2.6115 (0.5); 2.5946 (16.0); 2.5778 (0.5); 2.3044 (16.0); 2.0869 (0.6); 2.0785 (0.7); 2.0657 (1.2); 2.0528 (0.7); 2.0444 (0.7); 2.0311 (0.4); 1.8638 (0.3); 1.8515 (0.7); 1.8429 (0.8); 1.8307 (1.3); 1.8182 (0.8); 1.8098 (0.7); 1.7972 (0.3); 1.5620 (12.5); 1.0075 (1.6); 0.9955 (4.5); 0.9909 (4.8); 0.9793 (2.6); 0.9744 (4.6); 0.9699 (4.4); 0.9588 (1.8); 0.7641 (1.0); 0.7525 (2.8); 0.7490 (2.7); 0.7398 (2.5); 0.7359 (2.9); 0.7237 (0.9); 0.6825 (1.0); 0.6706 (3.0); 0.6668 (2.7); 0.6584 (2.4); 0.6543 (3.0); 0.6421 (0.8); -0.0002 (18.8)
I-838:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0109 (1.7); 7.4649 (2.4); 7.4448 (2.6); 7.2598 (15.7); 7.0706 (0.6); 7.0503 (2.0); 7.0379 (1.6); 7.0321 (4.0); 7.0213 (1.4); 7.0172 (1.5); 7.0014 (0.5); 6.9965 (0.4); 6.9500 (1.6); 6.9299 (1.4); 6.7850 (0.8); 6.7777 (0.8); 6.7684 (1.4); 6.7630 (1.2); 6.7494 (0.8); 6.7450 (0.7); 6.3862 (0.6); 6.3718 (1.1); 6.3559 (0.6); 4.4429 (1.1); 4.4269 (1.1); 4.4076 (2.4); 4.3916 (2.3); 4.3723 (1.2); 4.3563 (1.1); 2.9523 (12.0); 2.8794 (11.2); 2.5810 (16.0); 2.3677 (0.4); 2.2935 (11.0); 2.2626 (15.8); 2.1139 (0.4); 2.0815 (0.6); 2.0733 (0.7); 2.0605 (1.2); 2.0480 (0.7); 2.0394 (0.7); 1.5612 (12.7); 1.0155 (0.8); 1.0039 (2.3); 0.9991 (2.4); 0.9878 (1.3); 0.9826 (2.3); 0.9779 (2.3); 0.9670 (0.9); 0.7686 (1.0); 0.7570 (2.8); 0.7443 (2.5); 0.7405 (2.8); 0.7283 (0.8); -0.0002 (17.6)
I-839:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0110 (0.9); 7.2969 (1.9); 7.2722 (1.0); 7.2592 (9.7); 7.1365 (1.5); 7.1168 (1.2); 7.0568 (0.4); 7.0360 (1.9); 7.0217 (2.5); 7.0113 (1.1); 6.7714 (0.5); 6.7554 (0.8); 6.7485 (0.9); 6.7366 (0.6); 6.7311 (0.5); 6.3902 (0.4); 6.3761 (0.7); 6.3619 (0.4); 4.2089 (0.8); 4.1934 (0.8); 4.1734 (1.7); 4.1578 (1.6); 4.1379 (0.8); 4.1224 (0.8); 2.9517 (6.7); 2.8790 (6.2); 2.5841 (11.4); 2.2861 (0.4); 2.2607 (11.5); 2.2415 (16.0); 2.0717 (0.4); 2.0633 (0.5); 2.0505 (0.9); 2.0378 (0.5); 2.0296 (0.5); 1.5567 (12.1); 1.0050 (0.6); 0.9933 (1.6); 0.9885 (1.7); 0.9774 (0.9); 0.9721 (1.6); 0.9674 (1.6); 0.9565 (0.7); 0.7573 (0.7); 0.7455 (2.0); 0.7421 (1.9); 0.7333 (1.8); 0.7291 (2.0); 0.7170 (0.6); -0.0002 (12.7)
I-840:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0078 (1.7); 7.4864 (2.7); 7.4653 (2.3); 7.4452 (2.5); 7.2594 (15.7); 7.0899 (0.6); 7.0700 (1.8); 7.0504 (2.2); 7.0400 (1.4); 7.0245 (1.4); 7.0117 (1.7); 6.9930 (1.4); 6.8182 (0.8); 6.8131 (0.8); 6.8004 (1.4); 6.7824 (0.7); 6.4075 (0.6); 6.3927 (1.0); 6.3791 (0.6); 4.4663 (1.0); 4.4502 (1.0); 4.4310 (2.2); 4.4150 (2.1); 4.3957 (1.1); 4.3798 (1.0); 2.9518 (12.0); 2.8777 (11.2); 2.3774 (16.0); 2.2968 (10.1); 2.1532 (0.4); 2.0879 (0.6); 2.0791 (0.7); 2.0665 (1.1); 2.0541 (0.7); 2.0457 (0.6); 1.5487 (19.7); 1.0334 (0.7); 1.0218 (2.1); 1.0171 (2.2); 1.0056 (1.2); 1.0005 (2.2); 0.9959 (2.1); 0.9847 (0.8); 0.7782 (0.9); 0.7664 (2.6); 0.7539 (2.3); 0.7500 (2.6); 0.7377 (0.7); -0.0002 (21.0)
I-841:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0093 (1.4); 7.4993 (0.8); 7.4820 (1.4); 7.4653 (0.9); 7.4311 (0.7); 7.4123 (1.5); 7.3932 (1.0); 7.3687 (2.3); 7.3489 (2.6); 7.3015 (1.3); 7.2815 (2.0); 7.2599 (12.6); 7.1850 (2.9); 7.0387 (1.6); 7.0190 (1.5); 7.0084 (1.3); 6.8713 (2.5); 6.7343 (1.2); 6.3729 (0.6); 6.3586 (1.0); 6.3445 (0.6); 6.0628 (0.6); 6.0544 (0.6); 6.0453 (0.6); 6.0368 (0.6); 5.9460 (0.6); 5.9378 (0.6); 5.9289 (0.6); 5.9204 (0.6); 4.2366 (0.3); 4.2285 (0.3); 4.2200 (0.3); 4.2115 (0.3); 4.2002 (0.4); 4.1916 (0.4); 4.1833 (0.4); 4.1746 (0.5); 4.1624 (0.3); 4.1541 (0.3); 4.1456 (0.3); 4.1345 (0.4); 4.1265 (0.4); 4.1179 (0.4); 4.1096 (0.4); 3.9208 (0.4); 3.9067 (0.5); 3.8890 (0.4); 3.8844 (0.4); 3.8674 (0.7); 3.8531 (0.8); 3.8359 (0.4); 3.8313 (0.4); 3.8168 (0.4); 2.9517 (10.0); 2.8781 (9.4); 2.6248 (0.5); 2.6021 (15.9); 2.5778 (0.3); 2.3459 (0.4); 2.3189 (16.0); 2.2906 (12.0); 1.5595 (10.2); -0.0002 (16.0)
I-842:1 H-NMR(400.1 MHz, CDCl3): δ= 8.0044 (1.7); 7.5028 (0.7); 7.4851 (1.3); 7.4686 (0.9); 7.3992 (3.2); 7.3815 (1.5); 7.3627 (1.0); 7.3412 (1.9); 7.3202 (3.1); 7.3066 (1.4); 7.2865 (1.9); 7.2598 (16.5); 7.2426 (1.0); 7.0059 (1.2); 6.8689 (2.5); 6.7319 (1.2); 6.3998 (0.6); 6.3846 (1.1); 6.3705 (0.6); 4.2520 (1.1); 4.2360 (1.1); 4.2158 (2.3); 4.1999 (2.2); 4.1799 (1.2); 4.1639 (1.1); 2.9509 (12.0); 2.8760 (11.1); 2.5972 (16.0); 2.5293 (7.6); 2.2469 (15.6); 1.5541 (20.1); -0.0002 (19.8)
I-843:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9957 (1.4); 7.3385 (0.8); 7.3339 (0.8); 7.3153 (1.5); 7.3046 (0.9); 7.2905 (2.7); 7.2593 (12.1); 7.2432 (1.6); 7.1807 (0.5); 7.1760 (0.6); 7.1601 (1.7); 7.1554 (1.4); 7.1456 (4.1); 7.1427 (4.2); 7.1249 (2.7); 7.1016 (0.6); 6.3802 (0.6); 6.3657 (1.0); 6.3518 (0.6); 4.2067 (1.1); 4.1910 (1.1); 4.1712 (2.3); 4.1556 (2.2); 4.1357 (1.1); 4.1200 (1.1); 2.9492 (9.5); 2.8711 (8.9); 2.3722 (16.0); 2.2935 (0.4); 2.2798 (0.5); 2.2516 (13.2); 2.2432 (10.4); 1.5507 (14.3); -0.0002 (14.8)
I-844:1 H-NMR(400.1 MHz, CDCl3): δ= 7.9991 (1.8); 7.4917 (2.8); 7.4696 (2.4); 7.4495 (2.6); 7.3539 (0.7); 7.3497 (0.8); 7.3308 (1.4); 7.3199 (0.9); 7.3138 (0.8); 7.2597 (13.0); 7.1989 (0.5); 7.1954 (0.6); 7.1788 (1.6); 7.1744 (1.2); 7.1643 (1.7); 7.1589 (3.3); 7.1387 (1.6); 7.1186 (0.5); 7.0400 (1.5); 7.0201 (1.4); 6.3918 (0.6); 6.3774 (1.0); 6.3637 (0.6); 4.4648 (1.1); 4.4488 (1.1); 4.4292 (2.2); 4.4132 (2.1); 4.3936 (1.1); 4.3776 (1.1); 2.9502 (12.7); 2.8727 (12.0); 2.3893 (16.0); 2.3727 (0.5); 2.3061 (10.5); 2.1948 (0.4); 1.5515 (18.3); -0.0002 (17.3)
與上文所提供之實例類似地製備如下表3、表5、表7及表9中所示之化合物。此等化合物之1 H-NMR資料分別展示於表4、表6、表8及表10中。
表3 根據式(1)之化合物
Figure 02_image081
Ex N° R7 R8 Q U1 LogP
1-001 Cl 環丙基 3-(三氟甲基)苯基 甲氧基 3.94[a]
1-002 Cl 甲基 3-氯苯基 羥基 1.39[a]
1-003 Cl H 3-(二氟甲基)苯基 羥基 1.45[a]
1-004 甲基硫基 H 3-(三氟甲基)苯基 羥基 2.25[a]
1-005 Cl 甲基 3-環丙基-2-氟苯基 羥基 1.84[a]
1-006 甲基 甲基 3-(二氟甲基)-2-氟苯基 甲氧基 2.64[a]
1-007 氰基 H 3-(三氟甲基)苯基 羥基 1.74[a]
1-008 Cl 甲基 3-(三氟甲基)苯基 羥基 1.70[a]
1-009 甲基 甲基 2-氟-3-(三氟甲基)苯基 羥基 1.40[a]
1-010 甲基 H 3-(二氟甲基)-2-氟苯基 羥基 1.34[a]
1-011 Cl H 2,3-二氟苯基 異丙基氧基 3.65[a]
1-012 環丙基 H 3-(二氟甲基)苯基 羥基 1.68[a]
1-013 甲基 甲基 3-(二氟甲基)-2-氟苯基 羥基 0.96[a]
1-014 Cl 環丙基胺基 3-(三氟甲基)苯基 羥基 2.20[a]
1-015 Cl H 3-環丙基苯基 羥基 1.87[a]
1-016 環丙基 H 3-(二氟甲基)苯基 異丙基氧基 3.63[a]
1-017 Cl H 3-乙炔基苯基 羥基 1.50[a]
1-018 甲基 甲基 3-氯苯基 羥基 0.80[a]
1-019 甲基 H 5-(三氟甲基)吡啶-3-基 羥基 1.01[a]
1-020 3-氯吡啶-4-基 H 3-(二氟甲基)-2-氟苯基 羥基 1.86[a]
1-021 吡咯啶-1-基 H 3-(三氟甲基)苯基 羥基 1.08[a]
1-022 氰基 H 3-(三氟甲基)苯基 異丙基氧基 3.85[a]
1-023 Cl H 3-(二氟甲基)-2-氟苯基 異丙基氧基 3.68[a]
1-024 Cl H 2,3-二氟苯基 羥基 1.65[a]
1-025 Cl H 5-(三氟甲基)吡啶-3-基 羥基 1.31[a]
1-026 Cl 2-甲氧基乙基 3-(三氟甲基)苯基 羥基 1.74[a]
1-027 Cl 環丙基胺基 3-(三氟甲基)苯基 甲氧基 3.35[a]
1-028 Cl H 3-環丙基-2-氟苯基 羥基 2.01[a]
1-029 1H-咪唑-1-基 H 3-(三氟甲基)苯基 羥基 1.14[a]
1-030 乙基 H 3-(三氟甲基)苯基 羥基 1.82[a]
1-031 Cl H 6-(三氟甲基)吡啶-2-基 羥基 0.69[b]
1-032 吡咯啶-1-基 H 3-(三氟甲基)苯基 異丙基氧基 3.62[a]
1-033 Cl 甲基 3-氯苯基 甲氧基 3.37[a]
1-034 乙醯基 H 3-(三氟甲基)苯基 羥基 2.01[a]
1-035 乙基 H 3-(三氟甲基)苯基 異丙基氧基 3.96[a]
1-036 甲基 H 5-(三氟甲基)吡啶-3-基 乙氧基 2.37[a]
1-037 甲基 甲基 3-環丙基苯基 羥基 1.10[a]
1-038 Cl 乙氧基 3-(三氟甲基)苯基 羥基 1.96[a]
1-039 乙烯基 H 3-(三氟甲基)苯基 異丙基氧基 4.01[a]
1-040 甲基 H 3-環丙基苯基 羥基 1.46[a]
1-041 甲基 H 2-氟-3-(三氟甲基)苯基 甲氧基 2.90[a]
1-042 甲基 甲基 3-氯苯基 甲氧基 2.71[a]
1-043 環丙基 H 3-(三氟甲基)苯基 羥基 1.90[a]
1-044 Cl H 2-氟-3-(三氟甲基)苯基 羥基 1.98[a]
1-045 Cl H 3-乙炔基苯基 異丙基氧基 3.64[a]
1-046 Cl 甲氧基 3-(三氟甲基)苯基 甲氧基 3.52[a]
1-047 Cl H 2-氟-3-(三氟甲基)苯基 甲氧基 3.35[a]
1-048 Cl H 3-溴苯基 羥基 1.66[a]
1-049 Cl Cl 3-(三氟甲基)苯基 甲氧基 3.86[a]
1-050 1H-咪唑-1-基 H 3-(三氟甲基)苯基 異丙基氧基 2.55[a]
1-051 Cl H 5-環丙基吡啶-3-基 羥基 0.59[b]
1-052 Cl I 3-(三氟甲基)苯基 甲氧基 3.25[a]
1-053 3-氯吡啶-4-基 H 2,3-二氟苯基 羥基 1.22[a]
1-054 乙基 甲基 3-(三氟甲基)苯基 羥基 1.54[a]
1-055 Cl Cl 3-(二氟甲基)-2-氟苯基 甲氧基 3.51[a]
1-056 Cl Cl 3-環丙基苯基 乙氧基 4.41[a]
1-057 三氟甲基 H 3-(三氟甲基)苯基 羥基 2.27[a]
1-058 Cl H 3-環丙基-2-氟苯基 異丙基氧基 4.30[a]
1-059 三氟甲基 H 3-(三氟甲基)苯基 異丙基氧基 4.34[a]
1-060 Cl 乙氧基 3-(三氟甲基)苯基 乙氧基 4.23[a]
1-061 Cl H 3-環丙基苯基 異丙基氧基 4.15[a]
1-062 Cl H 3-(二氟甲基)-2-氟苯基 羥基 1.63[a]
1-063 Cl H 5-溴吡啶-3-基 羥基 0.94[a] ;0.53[b]
1-064 Cl Cl 2-氟-3-(三氟甲基)苯基 甲氧基 3.96[a]
1-065 Cl 甲基 3-環丙基-2-氟苯基 異丙基氧基 4.51[a]
1-066 I H 3-(三氟甲基)苯基 異丙基氧基 4.25[a]
1-067 甲基 H 2-氟-3-(三氟甲基)苯基 羥基 1.75[a]
1-068 環丙基胺基 H 3-(三氟甲基)苯基 異丙基氧基 3.23[a]
1-069 Cl 乙烯基 3-(三氟甲基)苯基 甲氧基 3.94[a]
1-070 甲基 甲基 3-(三氟甲基)苯基 羥基 1.52[a]
1-071 Cl H 6-(三氟甲基)吡啶-2-基 甲氧基 2.69[b]
1-072 1-乙氧基乙烯-1-基 H 3-(三氟甲基)苯基 異丙基氧基 4.90[a]
1-073 Cl Cl 3-環丙基-2-氟苯基 異丙基氧基 4.92[a]
1-074 3-氯吡啶-4-基 H 2,3-二氟苯基 異丙基氧基 3.65[a]
1-075 乙醯基 H 3-(三氟甲基)苯基 異丙基氧基 4.01[a]
1-076 Cl H 5-環丙基吡啶-3-基 乙氧基 2.60[b]
1-077 甲基 甲基 3-環丙基-2-氟苯基 羥基 1.31[a]
1-078 Cl 甲基 3-環丙基苯基 異丙基氧基 4.41[a]
1-079 Cl H 3-(三氟甲基)苯基 甲氧基 3.27[a]
1-080 甲基 甲基 3-環丙基苯基 異丙基氧基 3.63[a]
1-081 Cl 甲基 3-環丙基苯基 羥基 1.70[a]
1-082 甲基 甲基 3-(三氟甲基)苯基 甲氧基 2.98[a]
1-083 甲基硫基 H 3-(三氟甲基)苯基 乙氧基 3.96[a]
1-084 Cl 1H-吡唑-1-基 3-(三氟甲基)苯基 甲氧基 3.53[a]
1-085 Cl 苯基 3-(三氟甲基)苯基 甲氧基 4.25[a]
1-086 Cl H 5-溴吡啶-3-基 甲氧基 2.33[a]
1-087 Cl 甲基 3-(三氟甲基)苯基 甲氧基 3.55[a]
1-088 Cl H 5-(三氟甲基)吡啶-3-基 乙氧基 3.00[a]
1-089 Cl H 2-氟-3-甲醯基苯基 異丙基氧基 3.19[a]
1-090 Cl H 2-氟-3-乙烯基苯基 異丙基氧基 4.11[a]
1-091 Cl H 3-乙醯基苯基 異丙基氧基 3.08[a]
1-092 Cl H 2-氟-3-乙烯基苯基 羥基 1.82[a]
1-093 Cl H 3-乙醯基苯基 羥基 1.01[a]
1-094 Cl H 3-[rac-2,2-二氟環丙基]苯基 羥基 1.87[a]
1-095 Cl H 3-(1-氟環丙基)苯基 羥基 1.82[a]
1-096 Cl H 3-[rac-2,2-二氟環丙基]苯基 異丙基氧基 3.96[a]
1-097 Cl H 3-(1-氟環丙基)苯基 異丙基氧基 3.99[a]
1-098 甲基 H 3-(二氟甲基)苯基 羥基 1.36[a]
1-099 Cl H 3-環丙基-2-氟苯基 甲氧基 3.45[a]
1-100 甲基 H 3-環丙基-2-氟苯基 甲氧基 2.89[a]
1-101 Cl 甲基 3-環丙基-2-氟苯基 甲氧基 3.70[a]
1-102 Cl H 5-(二氟甲基)吡啶-3-基 異丙基氧基 2.82[a]
1-103 Cl 甲基 3-[rac-2,2-二氟環丙基]苯基 異丙基氧基 4.15[a]
1-104 Cl 甲基 3-(1-氟環丙基)苯基 羥基 1.63[a]
1-105 Cl 甲基 3-[rac-2,2-二氟環丙基]苯基 羥基 1.69[a]
1-106 Cl 甲基 3-(1-氟環丙基)苯基 異丙基氧基 4.25[a]
1-107 Cl H 2-氟-3-[rac-2,2-二氟環丙基]苯基 異丙基氧基 3.96[a]
1-108 Cl H 2-氟-3-[rac-2,2-二氟環丙基]苯基 羥基 1.81[a]
1-109 Cl 甲基 2-氟-3-[rac-2,2-二氟環丙基]苯基 異丙基氧基 4.23[a]
1-110 Cl 甲基 2-氟-3-[rac-2,2-二氟環丙基]苯基 羥基 1.82[a]
1-111 甲基 H 3-環丙基-2-氟苯基 羥基 1.70[a]
1-112 甲基 H 3-環丙基-2-氟苯基 乙氧基 3.29[a]
1-113 Cl H 2-氟-3-(1-氟環丙基)苯基 羥基 1.99[a]
1-114 Cl H 2-氟-3-(1-氟環丙基)苯基 異丙基氧基 4.62[a]
1-115 Cl 甲基 2-氟-3-(1-氟環丙基)苯基 異丙基氧基 4.33[a]
1-116 Cl 甲基胺基 3-環丙基-2-氟苯基 羥基 1.97[a]
1-117 Cl 甲基 3-(二氟甲基)-2-氟苯基 羥基 1.49[a]
1-118 Cl H 3-氯-2-氟苯基 異丙基-氧基 4.08[a]
1-119 Cl H 3-氯-2-氟苯基 乙氧基 3.60[a]
1-120 甲基 H 3-氯-2-氟苯基 異丙基-氧基 3.44[a]
1-121 Cl 甲基 3-氯-2-氟苯基 乙氧基 3.88[a]
1-122 Cl 甲基 3-氯-2-氟苯基 羥基 1.68[a]
1-123 甲基 H 3-氯-2-氟苯基 羥基 1.46[a]
1-124 Cl H 3-(二氟甲基)苯基 甲氧基 2.76[a]
1-125 甲基 H 3-(三氟甲基)苯基 羥基 1.92[a]
1-126 甲基 H 3-(三氟甲基)苯基 甲氧基 2.77[a]
1-127 I H 3-(三氟甲基)苯基 羥基 2.08[a]
1-128 Cl 2-甲氧基乙基 3-(三氟甲基)苯基 甲氧基 3.54[a]
1-129 H H 3-(三氟甲基)苯基 羥基 1.47[a]
1-130 Cl H 3-溴苯基 乙氧基 3.65[a]
表4：
1-001:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6086 (1.0); 7.5857 (2.9); 7.5630 (4.8); 7.5094 (2.6); 7.4687 (1.6); 7.4604 (1.9); 7.4527 (1.3); 7.4386 (1.2); 7.3072 (2.2); 4.1198 (0.9); 4.1038 (4.6); 4.0794 (2.2); 4.0641 (16.0); 2.0544 (0.7); 2.0452 (0.7); 2.0348 (0.6); 2.0257 (1.3); 2.0166 (0.6); 2.0060 (0.8); 1.9969 (0.8); 1.9771 (0.4); 1.7052 (0.5); 1.2520 (1.0); 1.2311 (2.7); 1.2050 (2.6); 1.1848 (1.0); 1.1659 (0.3); 0.9016 (1.0); 0.8822 (3.0); 0.8638 (2.9); 0.8443 (0.7); 0.0432 (1.5)
1-002:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 7.5070 (1.3); 7.4907 (2.9); 7.4745 (1.9); 7.3950 (1.2); 7.3909 (2.6); 7.3866 (1.8); 7.3766 (1.4); 7.3749 (1.6); 7.3727 (1.1); 7.3709 (1.0); 7.3605 (1.1); 7.3588 (1.1); 7.3566 (0.9); 7.3549 (0.8); 7.2279 (1.1); 7.2262 (1.2); 7.2234 (1.2); 7.2217 (1.1); 7.2115 (1.0); 7.2098 (1.0); 7.2069 (1.1); 7.2052 (0.9); 3.4043 (0.6); 3.3903 (1.0); 3.3763 (1.2); 3.3622 (1.5); 3.3227 (3.4); 2.5080 (5.7); 2.5044 (12.3); 2.5008 (17.2); 2.4972 (12.5); 2.4936 (5.9); 2.3962 (16.0); 2.3388 (0.8); 1.0907 (0.6); 0.0063 (0.3); -0.0002 (11.1); -0.0068 (0.4)
1-003:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.2400 (16.0); 7.6498 (2.3); 7.6302 (5.4); 7.6106 (3.8); 7.5151 (4.9); 7.4824 (7.4); 7.4627 (4.5); 7.4423 (3.4); 7.2113 (3.0); 7.0721 (6.5); 6.9329 (3.2); 2.5098 (2.1)
1-004:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9586 (5.4); 7.6341 (0.4); 7.6086 (1.4); 7.5827 (3.4); 7.5381 (2.1); 7.4940 (0.9); 7.4874 (1.4); 7.4806 (0.8); 7.4634 (0.9); 7.2986 (7.0); 2.7208 (16.0); 2.0934 (0.6); 1.2945 (1.0); 0.1080 (1.4); 0.0377 (7.1)
1-005:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 7.2008 (0.5); 7.1974 (0.6); 7.1845 (1.3); 7.1815 (1.2); 7.1714 (1.3); 7.1667 (1.4); 7.1639 (2.1); 7.1483 (1.9); 7.1323 (0.7); 6.9341 (0.8); 6.9309 (0.8); 6.9188 (1.1); 6.9163 (1.2); 6.9061 (0.6); 6.9020 (0.5); 2.5135 (0.4); 2.5099 (0.5); 2.5063 (0.4); 2.3968 (16.0); 2.3846 (0.4); 2.0707 (0.6); 2.0641 (0.6); 2.0539 (1.1); 2.0436 (0.7); 2.0371 (0.6); 1.0253 (0.9); 1.0166 (2.2); 1.0122 (2.3); 1.0086 (1.3); 1.0039 (1.3); 0.9997 (2.2); 0.9953 (2.2); 0.9871 (0.9); 0.7823 (1.0); 0.7739 (2.4); 0.7720 (2.1); 0.7698 (2.5); 0.7637 (2.4); 0.7596 (2.5); 0.7507 (0.8)
1-006:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5290 (0.6); 7.5080 (0.9); 7.4879 (0.9); 7.4660 (1.0); 7.4416 (0.7); 7.3266 (0.8); 7.2985 (5.1); 7.2731 (0.4); 7.0951 (0.8); 6.9124 (1.6); 6.7296 (0.8); 5.3346 (2.5); 4.0782 (0.4); 4.0489 (16.0); 4.0352 (0.3); 3.7395 (12.7); 2.6582 (11.6); 2.6276 (1.4); 2.4314 (1.4); 2.3595 (11.5); 1.2908 (0.4); 0.0358 (4.9)
1-007:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 8.7747 (0.7); 8.6615 (16.0); 7.7649 (2.3); 7.7481 (11.4); 7.7336 (5.6); 7.7141 (6.8); 7.6986 (3.1); 7.6491 (4.7); 7.6326 (3.3); 6.9206 (1.2); 2.5059 (7.3); 2.5030 (9.5); 1.3543 (2.5); 1.3417 (2.3); 1.3262 (0.6); 1.3136 (0.7); 1.2963 (0.5); 1.2838 (0.5); 1.2584 (2.1); 1.2445 (2.1); 1.2355 (0.4); 1.1970 (4.6); 1.1837 (0.4); 1.1708 (4.7); 1.1593 (1.6); 1.1457 (1.5); 0.8848 (1.5); 0.8714 (1.5); -0.0002 (4.0)
1-008:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.7747 (2.4); 7.7475 (8.1); 7.7204 (13.3); 7.7120 (13.1); 7.6924 (16.0); 7.6526 (0.5); 7.6169 (7.8); 7.5910 (5.1); 3.6770 (0.3); 3.6257 (0.3); 3.6165 (0.3); 3.5687 (0.4); 3.5321 (0.4); 3.4984 (0.4); 3.4631 (0.4); 3.4373 (0.4); 3.4027 (0.4); 3.3673 (0.4); 3.2814 (0.3); 3.2318 (0.3); 2.6507 (0.6); 2.5397 (13.4); 2.5340 (16.5); 2.4347 (75.8); 2.2151 (0.4); 2.1066 (1.0); 1.3861 (0.4); 1.2634 (1.1); 1.2122 (0.8); 0.0288 (8.6)
1-009:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 14.8115 (0.3); 14.7538 (0.3); 14.6902 (0.4); 14.6014 (0.5); 14.5796 (0.7); 14.5446 (0.7); 14.4728 (0.9); 14.4307 (0.9); 14.4079 (0.9); 14.3765 (0.9); 14.3065 (0.6); 14.1519 (0.3); 14.1207 (0.4); 9.1033 (0.4); 8.0407 (1.1); 7.9545 (0.4); 7.8137 (7.8); 7.7870 (15.2); 7.7589 (14.7); 7.7529 (14.6); 7.7304 (9.1); 7.6828 (0.7); 7.6495 (0.8); 7.6320 (1.1); 7.6041 (1.3); 7.5547 (10.6); 7.5277 (16.0); 7.5005 (7.2); 7.4590 (0.8); 7.4324 (0.6); 7.4063 (0.3); 5.7771 (9.2); 4.0856 (0.8); 4.0616 (2.3); 4.0379 (2.4); 4.0143 (0.9); 3.9930 (0.7); 3.8624 (0.3); 3.8231 (0.4); 3.7943 (0.4); 3.5999 (1.0); 3.4738 (1.7); 3.4515 (1.7); 3.2850 (0.9); 3.2784 (0.9); 3.2157 (0.8); 3.1459 (0.5); 3.0680 (0.4); 2.7895 (0.6); 2.7555 (0.4); 2.6425 (2.5); 2.5763 (133.4); 2.5478 (10.4); 2.5344 (20.9); 2.5286 (40.2); 2.5226 (53.5); 2.5166 (39.7); 2.5108 (20.7); 2.4461 (1.7); 2.4317 (2.8); 2.4261 (2.1); 2.3921 (7.9); 2.3463 (134.0); 2.2794 (1.6); 2.2677 (1.7); 2.2250 (0.6); 2.2020 (0.8); 2.1764 (0.5); 2.1343 (1.0); 2.0990 (0.3); 2.0092 (9.8); 1.9298 (9.1); 1.3765 (0.6); 1.3450 (0.4); 1.2909 (0.7); 1.2568 (3.2); 1.2186 (3.1); 1.1948 (5.8); 1.1712 (2.8); 1.0760 (0.6); 0.8726 (0.7); 0.8511 (0.4); 0.0694 (4.6); 0.0303 (2.2); 0.0195 (50.2); -0.0400 (3.5); -0.1098 (0.4)
1-010:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 14.2011 (0.4); 10.2674 (0.6); 8.9248 (2.2); 8.0180 (16.0); 7.9688 (0.4); 7.8521 (1.4); 7.7464 (0.5); 7.7246 (0.4); 7.7033 (0.4); 7.6763 (0.9); 7.6578 (2.1); 7.6321 (3.8); 7.6080 (3.8); 7.5862 (3.6); 7.5655 (2.3); 7.5330 (0.6); 7.5061 (1.3); 7.4754 (4.2); 7.4668 (4.6); 7.4489 (4.7); 7.4222 (1.9); 7.3531 (0.7); 7.3258 (1.0); 7.3083 (0.5); 7.2958 (1.3); 7.2866 (6.9); 7.1718 (1.3); 7.1445 (1.2); 7.1274 (1.8); 7.1065 (3.5); 7.0373 (0.3); 7.0178 (0.4); 7.0042 (0.5); 6.9905 (0.7); 4.0613 (0.8); 4.0375 (0.8); 3.7670 (0.4); 3.3472 (1.7); 2.7593 (4.4); 2.6359 (41.0); 2.5341 (6.7); 2.5282 (13.7); 2.5221 (18.8); 2.5160 (13.8); 2.5101 (6.7); 2.3931 (0.5); 2.3888 (0.5); 2.0089 (3.7); 1.9294 (9.0); 1.2184 (1.0); 1.1947 (2.0); 1.1710 (1.0); 0.0689 (7.2); 0.0306 (0.9); 0.0197 (20.4); 0.0087 (1.0)
1-011:1 H-NMR(499.9 MHz, CDCl3): δ= 7.9025 (16.0); 7.2682 (1.7); 7.1612 (0.4); 7.1501 (0.4); 7.1441 (1.2); 7.1418 (1.3); 7.1392 (0.7); 7.1350 (1.4); 7.1286 (5.4); 7.1224 (1.5); 7.1174 (5.0); 7.1116 (3.2); 7.1094 (3.4); 7.1055 (1.4); 7.1004 (3.8); 7.0977 (3.0); 7.0957 (2.6); 7.0911 (1.2); 7.0868 (1.2); 7.0829 (0.8); 7.0801 (1.0); 7.0759 (0.7); 5.3491 (1.2); 5.3365 (3.0); 5.3240 (4.0); 5.3115 (3.0); 5.2990 (1.2); 5.2957 (0.8); 1.6368 (0.3); 1.4341 (0.5); 1.4161 (42.0); 1.4035 (42.8); -0.0002 (1.8)
1-012:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 14.0811 (0.4); 8.8902 (0.8); 7.9241 (16.0); 7.6373 (1.5); 7.6113 (3.6); 7.5856 (2.5); 7.5642 (0.4); 7.5453 (0.4); 7.4873 (3.3); 7.4616 (2.3); 7.3962 (7.2); 7.3700 (2.0); 7.3664 (2.2); 7.3624 (1.8); 7.2598 (2.6); 7.1170 (0.3); 7.0742 (5.6); 6.9478 (0.9); 6.9437 (0.6); 6.8886 (2.8); 3.3517 (1.0); 2.9129 (0.7); 2.7545 (0.6); 2.5366 (2.8); 2.5306 (6.0); 2.5245 (8.2); 2.5185 (5.9); 2.5125 (2.8); 2.3887 (0.6); 2.3720 (1.4); 2.3614 (1.5); 2.3565 (1.1); 2.3449 (2.5); 2.3394 (1.6); 2.3282 (1.5); 2.3177 (1.5); 2.3011 (0.8); 1.3786 (1.0); 1.1384 (1.3); 1.1215 (2.9); 1.1130 (5.3); 1.1031 (3.3); 1.0939 (3.0); 1.0854 (4.5); 1.0771 (3.2); 1.0613 (3.1); 1.0515 (4.9); 1.0434 (6.2); 1.0355 (5.0); 1.0268 (4.0); 1.0092 (1.0); 0.0328 (0.4); 0.0220 (9.4); 0.0110 (0.4); -0.0377 (0.5)
1-013:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 19.2951 (0.4); 14.7822 (0.4); 14.6202 (0.4); 14.5848 (0.5); 14.5179 (0.6); 14.3702 (0.8); 14.3517 (0.7); 14.1893 (0.4); 9.0845 (0.4); 7.8097 (0.4); 7.7436 (1.0); 7.6771 (2.0); 7.6436 (4.9); 7.6131 (12.1); 7.5875 (12.2); 7.5658 (5.6); 7.4690 (10.2); 7.4603 (9.4); 7.4436 (10.6); 7.4165 (4.0); 7.3482 (0.5); 7.3176 (0.8); 7.3055 (1.9); 7.2939 (3.5); 7.2801 (16.0); 7.1254 (0.9); 7.1135 (1.6); 7.1000 (7.8); 4.0617 (0.7); 4.0382 (0.7); 3.9452 (0.4); 3.8251 (0.8); 3.7670 (0.4); 3.7152 (0.4); 3.6224 (1.0); 3.5890 (1.2); 3.3665 (6.5); 3.1389 (0.8); 3.0599 (0.6); 3.0068 (0.4); 2.9597 (0.5); 2.9355 (0.4); 2.7846 (0.5); 2.7489 (0.6); 2.6828 (6.6); 2.6379 (0.6); 2.5709 (87.4); 2.5342 (30.6); 2.5282 (63.1); 2.5222 (86.3); 2.5161 (63.2); 2.5102 (30.7); 2.4628 (1.3); 2.4391 (11.3); 2.4239 (9.3); 2.3839 (2.0); 2.3388 (86.0); 2.2941 (1.3); 2.2557 (1.8); 2.1740 (0.4); 2.1268 (0.6); 2.0094 (2.9); 1.9296 (0.4); 1.7920 (0.4); 1.7800 (0.6); 1.2193 (0.9); 1.1954 (1.6); 1.1715 (0.7); 0.0316 (2.6); 0.0208 (75.5); 0.0098 (3.6); -0.0348 (0.4); -0.1782 (0.4); -2.4204 (0.4); -3.4823 (0.4)
1-014:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6445 (0.5); 7.5698 (2.7); 7.5445 (7.8); 7.5195 (16.0); 7.5093 (9.8); 7.4764 (11.2); 7.4396 (5.2); 7.4332 (8.1); 7.4263 (4.2); 7.4086 (5.5); 7.3826 (0.6); 7.3637 (0.7); 7.3254 (0.6); 7.3137 (0.6); 7.2986 (53.8); 7.2646 (0.4); 6.2623 (0.4); 6.1844 (3.5); 6.0638 (0.7); 6.0086 (0.3); 4.1995 (0.8); 4.1756 (2.3); 4.1519 (2.3); 4.1283 (0.8); 3.9955 (1.5); 3.7885 (5.4); 2.9593 (1.0); 2.9468 (2.0); 2.9363 (3.0); 2.9243 (4.0); 2.9173 (4.2); 2.9054 (2.9); 2.8954 (2.1); 2.8833 (1.1); 2.1754 (0.6); 2.0898 (11.2); 1.3210 (2.9); 1.2972 (5.9); 1.2734 (2.9); 1.2573 (0.8); 1.0060 (0.5); 0.9871 (0.6); 0.9703 (0.5); 0.9336 (2.4); 0.9096 (10.1); 0.8908 (10.0); 0.8686 (4.7); 0.8384 (1.8); 0.8233 (1.3); 0.8183 (1.3); 0.7839 (4.0); 0.7680 (10.0); 0.7601 (11.9); 0.7312 (2.6); 0.0482 (1.6); 0.0450 (0.8); 0.0374 (52.7); 0.0282 (1.7); 0.0265 (2.1)
1-015:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2130 (16.0); 7.3593 (2.5); 7.3332 (5.6); 7.3070 (3.4); 7.0221 (3.3); 7.0179 (3.1); 7.0083 (2.7); 7.0051 (2.6); 7.0002 (5.0); 6.9971 (5.0); 6.9819 (1.8); 6.9786 (1.8); 6.9739 (3.5); 6.9708 (2.8); 6.9607 (4.6); 6.9548 (5.0); 6.9484 (2.6); 5.7756 (1.8); 2.5344 (1.4); 2.5284 (3.0); 2.5223 (4.1); 2.5162 (3.0); 2.5103 (1.4); 2.0139 (0.6); 2.0090 (0.4); 1.9970 (1.2); 1.9859 (1.4); 1.9807 (1.0); 1.9693 (2.6); 1.9578 (1.0); 1.9524 (1.5); 1.9414 (1.4); 1.9245 (0.7); 1.0128 (1.6); 0.9983 (4.4); 0.9908 (4.9); 0.9852 (2.4); 0.9772 (2.6); 0.9702 (4.7); 0.9628 (4.5); 0.9494 (2.0); 0.7347 (2.0); 0.7209 (5.0); 0.7178 (4.2); 0.7139 (5.2); 0.7044 (4.8); 0.6974 (5.3); 0.6822 (1.6); 0.0194 (4.1)
1-016:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6954 (5.4); 7.5477 (0.5); 7.5212 (1.3); 7.4941 (1.1); 7.4005 (1.2); 7.3983 (1.2); 7.3790 (2.2); 7.3462 (0.6); 7.3427 (0.7); 7.3391 (0.6); 7.2996 (2.6); 6.8673 (0.9); 6.6792 (1.9); 6.4912 (1.0); 5.3799 (0.5); 5.3589 (1.0); 5.3380 (1.4); 5.3172 (1.0); 5.2963 (0.4); 2.2223 (0.5); 2.2117 (0.6); 2.2003 (0.6); 2.1954 (0.9); 2.1838 (0.4); 2.1787 (0.6); 2.1681 (0.6); 1.6222 (2.1); 1.4442 (1.0); 1.4263 (16.0); 1.4054 (15.6); 1.2507 (0.4); 1.2320 (1.4); 1.2236 (1.7); 1.2147 (2.4); 1.2073 (1.6); 1.1971 (1.0); 1.1927 (0.7); 1.1785 (1.4); 1.1692 (1.7); 1.1609 (1.2); 1.1566 (0.8); 1.1520 (1.1); 1.1419 (2.0); 1.1334 (1.1); 1.1154 (0.4); 0.0373 (2.2)
1-017:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2024 (15.4); 7.5239 (2.4); 7.4978 (6.6); 7.4717 (5.7); 7.4224 (6.0); 7.4182 (4.4); 7.3968 (3.8); 7.3878 (4.6); 7.3809 (6.0); 7.3392 (3.5); 7.3355 (3.7); 7.3314 (3.0); 7.3276 (2.6); 7.3125 (2.6); 7.3085 (2.5); 7.3048 (2.4); 7.3008 (1.9); 4.3136 (16.0); 4.1188 (0.4); 4.0607 (0.7); 4.0373 (0.7); 3.4742 (0.5); 3.4406 (0.9); 3.3535 (3.2); 3.1825 (0.4); 3.1706 (0.4); 2.5342 (10.6); 2.5282 (23.5); 2.5222 (33.0); 2.5162 (24.2); 2.5103 (11.6); 2.0095 (3.2); 1.9291 (0.5); 1.2183 (0.8); 1.1947 (1.7); 1.1710 (0.8); 0.0311 (1.0); 0.0202 (37.5); 0.0092 (1.5)
1-018:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 7.4874 (1.5); 7.4711 (3.3); 7.4548 (2.0); 7.3409 (1.4); 7.3383 (1.7); 7.3224 (1.5); 7.3033 (1.9); 7.2990 (3.2); 7.2949 (1.8); 7.1631 (1.4); 7.1596 (1.4); 7.1467 (1.3); 7.1433 (1.3); 3.3599 (0.4); 2.5688 (16.1); 2.5531 (0.8); 2.5119 (2.6); 2.5084 (3.7); 2.5049 (2.9); 2.3225 (0.7); 2.3090 (16.0); 2.2943 (0.8)
1-019:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 14.1821 (0.3); 14.1522 (0.3); 14.1295 (0.3); 8.9947 (1.3); 8.9712 (0.5); 8.9384 (1.4); 8.9245 (6.4); 8.8856 (5.5); 8.8774 (5.5); 8.4370 (0.6); 8.3456 (0.6); 8.2841 (3.7); 8.2778 (5.8); 8.0392 (16.0); 7.8389 (1.1); 7.4574 (1.0); 6.5531 (0.6); 5.7793 (0.7); 3.3463 (8.6); 3.2149 (0.4); 3.1782 (0.4); 2.7764 (3.8); 2.7504 (0.4); 2.6563 (42.8); 2.5927 (0.5); 2.5359 (14.6); 2.5300 (31.2); 2.5239 (42.6); 2.5179 (30.6); 2.5121 (14.3); 2.4565 (0.4); 2.3903 (3.1); 1.2565 (1.1); 1.1966 (0.4); 0.0697 (5.9); 0.0328 (0.9); 0.0220 (28.2); 0.0111 (1.0)
1-020:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.9251 (0.3); 8.8698 (3.6); 8.7342 (2.5); 8.7177 (2.6); 8.5006 (5.4); 8.2939 (0.9); 8.0718 (0.4); 7.7863 (2.6); 7.7700 (2.3); 7.7560 (1.1); 7.7298 (0.6); 7.6669 (0.5); 7.6453 (1.1); 7.6245 (0.9); 7.5292 (1.0); 7.5046 (2.3); 7.4765 (0.8); 7.3255 (2.1); 7.3014 (0.4); 7.1455 (1.2); 7.1278 (0.4); 5.7769 (0.3); 3.5887 (0.6); 3.3438 (0.8); 2.5345 (3.5); 2.5286 (7.4); 2.5226 (10.2); 2.5166 (7.6); 2.5108 (3.7); 2.0095 (0.4); 1.9298 (1.9); 1.1796 (2.6); 1.0901 (16.0); 0.0313 (0.4); 0.0205 (11.3); 0.0096 (0.6); -0.0417 (0.4)
1-021:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.6610 (1.6); 7.6347 (4.1); 7.6081 (3.1); 7.5426 (3.9); 7.5167 (2.4); 7.4043 (5.0); 7.3769 (3.1); 7.3499 (2.4); 7.2994 (11.4); 4.0839 (0.8); 4.0603 (2.5); 4.0366 (2.6); 4.0129 (0.9); 3.5091 (5.2); 3.4874 (13.6); 3.4658 (5.4); 3.3528 (4.0); 2.5338 (5.3); 2.5280 (10.8); 2.5220 (14.6); 2.5160 (10.6); 2.5102 (5.0); 2.0160 (5.6); 2.0088 (16.0); 1.9945 (14.2); 1.9725 (5.0); 1.9290 (8.8); 1.4024 (0.7); 1.3815 (0.6); 1.2529 (0.5); 1.2177 (3.0); 1.1940 (5.9); 1.1703 (2.9); 0.0298 (0.6); 0.0191 (14.1); 0.0083 (0.7); -0.0416 (3.6)
1-022:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2527 (16.0); 7.8756 (2.0); 7.6838 (1.0); 7.6576 (4.6); 7.6377 (12.0); 7.6350 (10.4); 7.6223 (1.5); 7.5542 (5.6); 7.5276 (0.9); 7.5211 (0.8); 7.5111 (2.5); 7.5013 (3.8); 7.4938 (3.0); 7.4806 (2.6); 7.4730 (1.7); 7.3057 (4.7); 5.4583 (0.6); 5.4357 (1.6); 5.4146 (3.4); 5.3937 (4.4); 5.3728 (3.2); 5.3519 (1.3); 1.6910 (0.4); 1.6701 (0.6); 1.6389 (2.2); 1.5343 (6.3); 1.5134 (6.6); 1.4809 (47.7); 1.4601 (47.0); 1.2978 (0.3); 0.0405 (3.2)
1-023:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9376 (5.4); 7.6355 (0.5); 7.5766 (0.4); 7.5552 (0.8); 7.5345 (0.5); 7.5325 (0.5); 7.5089 (0.4); 7.5061 (0.4); 7.4818 (0.9); 7.4792 (0.8); 7.4575 (0.6); 7.4549 (0.6); 7.3709 (0.8); 7.3437 (1.2); 7.3177 (0.4); 7.2984 (2.8); 7.1103 (0.9); 6.9278 (1.8); 6.7452 (0.9); 5.4078 (0.4); 5.3870 (1.0); 5.3661 (1.3); 5.3452 (1.0); 5.3244 (0.4); 1.6170 (0.8); 1.4798 (1.5); 1.4609 (16.0); 1.4400 (15.1); 1.4256 (0.5); 1.4046 (0.4); 1.2465 (0.4); 0.0361 (2.9)
1-024:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.2813 (16.0); 7.4772 (0.6); 7.4716 (0.7); 7.4577 (1.4); 7.4525 (1.7); 7.4352 (1.9); 7.4272 (1.3); 7.4142 (1.0); 7.4089 (0.9); 7.3620 (0.8); 7.3584 (0.7); 7.3477 (0.8); 7.3409 (1.9); 7.3374 (2.0); 7.3258 (2.9); 7.3189 (4.4); 7.3098 (4.5); 7.3022 (2.6); 7.2816 (0.8); 2.5267 (0.6); 2.5220 (0.8); 2.5131 (5.9); 2.5087 (12.3); 2.5042 (16.8); 2.4997 (12.2); 2.4953 (6.0); -0.0013 (1.4); -0.0026 (1.2)
1-025:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.9709 (1.1); 8.9573 (4.6); 8.9551 (4.7); 8.9438 (4.4); 8.9353 (4.3); 8.4460 (0.3); 8.4354 (0.4); 8.4252 (0.5); 8.4165 (0.5); 8.3716 (2.7); 8.3654 (4.6); 8.3587 (2.7); 8.3239 (16.0); 8.0825 (1.7); 5.7786 (1.2); 4.0633 (0.4); 4.0395 (0.4); 3.6458 (0.4); 3.5738 (0.6); 3.5399 (0.7); 3.3575 (4.7); 3.0447 (1.0); 2.5362 (8.2); 2.5302 (18.1); 2.5241 (25.4); 2.5180 (18.5); 2.5120 (8.8); 2.0111 (1.8); 1.2566 (0.4); 1.2206 (0.4); 1.1969 (1.0); 1.1731 (0.5); 0.0330 (0.8); 0.0221 (26.6); 0.0112 (1.0)
1-026:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5917 (1.2); 7.5687 (5.0); 7.5142 (1.0); 7.5064 (1.4); 7.4985 (0.8); 7.4841 (0.7); 7.2987 (9.1); 3.9135 (1.8); 3.8940 (3.9); 3.8743 (2.3); 3.5053 (16.0); 3.2649 (2.1); 3.2454 (3.8); 3.2259 (2.1); 1.2932 (0.8); 1.1443 (0.6); 0.0373 (7.8)
1-027:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5541 (0.4); 7.5433 (0.9); 7.5165 (2.2); 7.5102 (1.3); 7.4902 (1.5); 7.4883 (1.4); 7.4831 (1.6); 7.4402 (0.7); 7.4327 (1.2); 7.4255 (0.6); 7.4169 (0.4); 7.4144 (0.4); 7.4090 (0.6); 7.4018 (0.3); 7.2985 (2.8); 5.6931 (0.8); 4.0184 (1.9); 4.0071 (0.4); 3.9923 (16.0); 2.7929 (0.4); 2.7891 (0.4); 2.7825 (0.4); 2.7771 (0.6); 2.7705 (0.7); 2.7651 (0.5); 2.7585 (0.4); 2.7550 (0.4); 2.7483 (0.4); 2.0802 (0.7); 1.6331 (0.7); 1.2941 (0.4); 0.8795 (1.4); 0.8742 (0.9); 0.8618 (1.4); 0.8570 (1.2); 0.8517 (0.9); 0.8395 (0.7); 0.8107 (0.4); 0.7720 (0.7); 0.7589 (1.5); 0.7490 (1.5); 0.7455 (1.5); 0.7325 (0.8); 0.7197 (0.3); 0.0350 (2.4)
1-028:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 8.2502 (16.0); 8.0080 (1.2); 7.2221 (0.5); 7.2063 (1.3); 7.2027 (1.4); 7.1899 (3.5); 7.1868 (3.2); 7.1767 (7.8); 7.1620 (5.1); 7.1458 (1.7); 6.9476 (2.0); 6.9442 (2.1); 6.9334 (2.8); 6.9290 (3.0); 6.9209 (1.5); 6.9154 (1.3); 2.5087 (2.8); 2.5051 (3.7); 2.5016 (2.6); 2.0890 (0.9); 2.0788 (1.6); 2.0720 (1.8); 2.0620 (2.9); 2.0519 (1.7); 2.0452 (1.5); 2.0348 (0.7); 1.9900 (0.6); 1.1759 (0.4); 1.0341 (2.4); 1.0255 (5.8); 1.0211 (5.8); 1.0175 (3.2); 1.0127 (3.3); 1.0086 (5.4); 1.0042 (5.4); 0.9960 (2.0); 0.8237 (0.4); 0.8130 (0.5); 0.7937 (2.7); 0.7854 (6.6); 0.7813 (6.5); 0.7753 (6.2); 0.7712 (6.0); 0.7622 (1.8)
1-029:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.7017 (8.2); 8.6822 (0.4); 8.6150 (16.0); 8.1049 (5.4); 8.1005 (8.6); 8.0962 (5.2); 8.0833 (0.5); 7.7696 (1.4); 7.7437 (4.2); 7.7183 (9.1); 7.6944 (5.6); 7.6687 (1.9); 7.6356 (3.6); 7.6090 (2.1); 7.2299 (7.3); 4.0835 (0.4); 4.0598 (0.9); 4.0362 (0.9); 4.0126 (0.4); 3.5263 (0.4); 3.4997 (0.4); 3.4710 (0.4); 3.4452 (0.4); 3.4323 (0.4); 3.3829 (0.4); 3.3265 (0.4); 2.5831 (0.4); 2.5341 (6.1); 2.5284 (11.2); 2.5224 (14.1); 2.5165 (9.7); 2.1057 (0.5); 2.0088 (3.5); 1.9293 (1.9); 1.3751 (1.0); 1.2838 (0.3); 1.2536 (1.2); 1.2174 (1.1); 1.1937 (2.0); 1.1700 (1.0); 0.0187 (3.2); 0.0077 (0.4); -0.0393 (1.5)
1-030:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.0139 (9.2); 7.7429 (0.8); 7.7169 (2.4); 7.6915 (2.4); 7.6678 (3.0); 7.6430 (4.7); 7.5644 (2.0); 7.5380 (1.5); 3.0021 (1.8); 2.9768 (5.6); 2.9515 (5.7); 2.9263 (1.9); 2.5341 (2.3); 2.5281 (4.7); 2.5221 (6.5); 2.5161 (4.7); 2.5102 (2.2); 2.0085 (0.5); 1.9290 (0.4); 1.3136 (7.2); 1.2884 (16.0); 1.2631 (6.9); 0.0182 (7.1); -0.0419 (1.3)
1-031:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.3847 (16.0); 8.3052 (2.0); 8.2779 (4.0); 8.2524 (2.4); 8.1524 (0.6); 7.8268 (5.3); 7.8021 (4.7); 7.6860 (4.6); 7.6582 (4.2); 4.0602 (0.4); 4.0364 (0.4); 2.5341 (3.6); 2.5281 (7.7); 2.5220 (10.6); 2.5159 (7.7); 2.5100 (3.7); 2.0087 (1.6); 1.2175 (0.4); 1.1937 (0.9); 1.1700 (0.4); 0.0295 (0.5); 0.0187 (13.3); 0.0077 (0.5)
1-033:1 H-NMR(499.9 MHz, CDCl3): δ= 7.3477 (0.7); 7.3458 (0.7); 7.3312 (1.8); 7.3180 (0.5); 7.3142 (1.3); 7.2703 (0.4); 7.2341 (3.4); 7.2310 (4.1); 7.2277 (1.7); 7.2192 (1.1); 7.2174 (1.2); 7.2155 (1.0); 7.2135 (0.8); 7.1244 (1.0); 7.1211 (1.5); 7.1178 (1.0); 7.1079 (0.9); 7.1060 (1.0); 7.1034 (1.0); 7.1015 (1.0); 4.0266 (0.5); 4.0054 (16.0); 2.4132 (15.4); 2.3714 (0.5); 2.0396 (0.6); 1.7227 (0.4); 1.2683 (0.4); 1.2628 (0.6); 1.2542 (0.6); 0.8930 (0.4); 0.8794 (1.0); 0.8651 (0.5); -0.0002 (0.4)
1-034:1 H-NMR(300.2 MHz, CDCl3): δ= 8.9312 (0.5); 8.7218 (5.7); 7.6865 (0.4); 7.6605 (1.5); 7.6368 (4.5); 7.6136 (0.6); 7.5818 (2.3); 7.5362 (1.0); 7.5285 (1.6); 7.5213 (0.9); 7.5058 (1.0); 7.2986 (8.3); 7.1162 (0.3); 4.1844 (0.7); 4.1606 (0.8); 3.8821 (0.4); 2.8702 (16.0); 2.6686 (1.2); 2.1970 (2.5); 2.1014 (3.4); 1.9497 (0.5); 1.6815 (0.4); 1.4679 (0.4); 1.4314 (0.3); 1.4067 (0.5); 1.3816 (0.5); 1.3593 (0.8); 1.3319 (0.6); 1.3261 (1.1); 1.3023 (2.0); 1.2902 (0.4); 1.2784 (1.0); 0.9825 (1.0); 0.9582 (1.8); 0.9340 (0.8); 0.1065 (0.7); 0.0352 (8.0); 0.0243 (0.4)
1-035:1 H-NMR(300.2 MHz, CDCl3): δ= 7.7672 (4.6); 7.5697 (1.0); 7.5431 (1.7); 7.5290 (2.2); 7.5215 (1.8); 7.4764 (0.8); 7.4707 (1.1); 7.4641 (0.7); 7.4453 (0.7); 7.2990 (5.2); 5.3887 (0.4); 5.3679 (1.0); 5.3470 (1.3); 5.3261 (1.0); 5.3053 (0.4); 3.1003 (1.0); 3.0749 (3.3); 3.0496 (3.4); 3.0243 (1.2); 1.6181 (9.2); 1.4489 (4.2); 1.4341 (16.0); 1.4236 (8.8); 1.4132 (15.9); 1.3982 (3.9); 0.1066 (1.2); 0.0359 (4.9)
1-037:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.3284 (1.1); 7.3025 (2.6); 7.2763 (1.6); 6.9713 (1.7); 6.9453 (1.6); 6.9167 (1.2); 6.9137 (1.3); 6.9088 (1.7); 6.9058 (1.5); 6.8794 (3.8); 6.8741 (2.7); 2.5667 (15.0); 2.5339 (2.5); 2.5280 (5.0); 2.5219 (7.0); 2.5158 (5.1); 2.5099 (2.5); 2.3802 (0.5); 2.3081 (14.9); 2.0993 (0.8); 1.9884 (0.7); 1.9772 (0.7); 1.9722 (0.6); 1.9606 (1.4); 1.9440 (0.9); 1.9294 (16.0); 1.9172 (0.7); 1.0060 (0.9); 0.9915 (2.4); 0.9840 (2.7); 0.9783 (1.4); 0.9704 (1.5); 0.9634 (2.6); 0.9560 (2.5); 0.9426 (1.1); 0.7213 (1.1); 0.7075 (2.6); 0.7043 (2.3); 0.7005 (2.9); 0.6909 (2.6); 0.6839 (2.9); 0.6689 (0.9); 0.0689 (0.8); 0.0203 (9.0); 0.0094 (0.4)
1-038:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.7702 (0.8); 7.7434 (2.8); 7.7162 (4.7); 7.7082 (4.7); 7.6845 (6.1); 7.6111 (2.9); 7.5856 (1.9); 4.4847 (2.5); 4.4615 (8.0); 4.4383 (8.2); 4.4152 (2.6); 2.5402 (5.1); 2.5347 (6.6); 2.5291 (4.9); 2.1077 (0.8); 1.4582 (7.9); 1.4350 (16.0); 1.4118 (7.7); 0.0305 (5.0)
1-039:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0165 (5.2); 7.5853 (1.0); 7.5593 (2.0); 7.5527 (1.6); 7.5470 (1.9); 7.5370 (1.8); 7.4918 (0.7); 7.4850 (1.1); 7.4782 (0.6); 7.4654 (0.4); 7.4598 (0.6); 7.2985 (4.6); 7.1094 (1.0); 7.0725 (1.2); 7.0501 (1.2); 7.0133 (1.2); 6.2880 (2.3); 6.2288 (2.0); 5.7406 (2.3); 5.7037 (2.1); 5.4053 (0.4); 5.3845 (1.0); 5.3636 (1.4); 5.3427 (1.0); 5.3219 (0.4); 1.6133 (1.8); 1.4481 (16.0); 1.4272 (15.8); 0.0363 (4.3)
1-040:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 7.8912 (5.7); 7.3097 (1.3); 7.2902 (2.8); 7.2706 (1.7); 6.9569 (2.0); 6.9376 (1.9); 6.9046 (1.9); 6.8752 (3.4); 2.6079 (16.0); 2.5101 (2.7); 1.9793 (0.3); 1.9665 (0.7); 1.9580 (0.9); 1.9458 (1.4); 1.9335 (1.0); 1.9250 (0.9); 1.9123 (0.4); 0.9823 (0.8); 0.9712 (2.4); 0.9660 (2.8); 0.9504 (2.7); 0.9453 (2.8); 0.9351 (1.2); 0.7049 (1.0); 0.6935 (3.0); 0.6899 (3.2); 0.6818 (3.0); 0.6774 (3.3); 0.6659 (1.0)
1-041:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8520 (4.3); 7.5819 (0.6); 7.5583 (1.4); 7.5372 (1.4); 7.5170 (0.7); 7.3531 (0.7); 7.3263 (1.1); 7.2986 (2.2); 4.0423 (16.0); 2.7528 (14.2); 1.2898 (0.5); 0.0335 (1.6)
1-042:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3686 (0.8); 7.3420 (2.0); 7.3153 (1.4); 7.3147 (1.4); 7.2987 (1.1); 7.2644 (0.9); 7.2579 (1.9); 7.2513 (1.4); 7.2398 (1.1); 7.2362 (1.4); 7.2337 (0.9); 7.2298 (0.8); 7.2132 (0.7); 7.2097 (0.7); 7.2068 (0.6); 7.2033 (0.5); 7.1579 (1.0); 7.1542 (0.9); 7.1504 (0.9); 7.1469 (0.8); 7.1308 (0.7); 7.1273 (0.7); 7.1231 (0.7); 7.1197 (0.6); 4.0279 (0.5); 4.0261 (0.5); 4.0170 (16.0); 4.0079 (0.9); 2.6590 (12.4); 2.6426 (0.5); 2.3363 (12.3); 2.3225 (0.6); 1.7379 (2.0); 1.2966 (0.4); 1.2893 (0.4); 0.9120 (0.4); 0.0307 (0.8)
1-043:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 7.9195 (16.0); 7.7070 (2.1); 7.6877 (5.3); 7.6679 (4.5); 7.6347 (6.0); 7.6031 (7.9); 7.5251 (4.2); 7.5050 (3.6); 4.0031 (0.3); 3.3797 (1.1); 3.3371 (1.2); 2.5098 (7.0); 2.3668 (0.8); 2.3544 (1.8); 2.3460 (2.2); 2.3338 (3.6); 2.3219 (2.4); 2.3137 (2.1); 2.3014 (1.1); 1.1157 (1.5); 1.1036 (4.1); 1.0975 (7.0); 1.0901 (4.4); 1.0829 (4.6); 1.0773 (7.0); 1.0697 (3.7); 1.0559 (1.5); 1.0430 (3.3); 1.0352 (7.4); 1.0301 (7.4); 1.0232 (8.0); 1.0174 (6.1); 1.0055 (2.2)
1-044:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2409 (16.0); 8.1115 (0.6); 7.9405 (1.1); 7.8747 (1.8); 7.8503 (3.7); 7.8227 (2.3); 7.8127 (2.0); 7.7868 (3.6); 7.7656 (2.3); 7.5853 (2.5); 7.5587 (4.1); 7.5321 (1.8); 4.1145 (0.5); 4.0839 (0.4); 4.0726 (1.0); 4.0489 (1.0); 3.5064 (0.4); 3.3515 (0.6); 3.3099 (0.5); 3.0723 (1.7); 3.0521 (0.7); 3.0411 (0.5); 3.0096 (0.3); 2.9228 (1.8); 2.8928 (0.7); 2.8579 (0.4); 2.7637 (1.5); 2.5463 (9.6); 2.5404 (20.1); 2.5343 (27.5); 2.5283 (19.6); 2.5224 (9.0); 2.0211 (3.9); 1.3872 (0.8); 1.2914 (0.5); 1.2660 (1.1); 1.2300 (1.3); 1.2062 (2.6); 1.2012 (1.1); 1.1825 (1.2); 0.1641 (0.4); 0.1162 (0.4); 0.0419 (0.5); 0.0310 (14.4); 0.0201 (0.6)
1-045:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8837 (5.5); 7.4257 (2.7); 7.4229 (2.9); 7.4137 (1.5); 7.4095 (2.0); 7.4066 (2.2); 7.4050 (2.1); 7.3802 (1.6); 7.3754 (1.5); 7.3722 (1.4); 7.2987 (3.2); 7.2777 (0.9); 7.2693 (0.8); 7.2661 (0.7); 7.2581 (0.8); 7.2518 (0.6); 7.2466 (0.6); 7.2385 (0.5); 5.3876 (0.4); 5.3668 (1.0); 5.3459 (1.4); 5.3250 (1.0); 5.3042 (0.4); 3.1337 (4.6); 1.6009 (4.7); 1.4411 (16.0); 1.4203 (15.8); 0.0368 (3.7)
1-046:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6042 (0.4); 7.5790 (1.6); 7.5575 (4.1); 7.5025 (2.2); 7.4823 (0.3); 7.4642 (1.0); 7.4556 (1.4); 7.4482 (1.0); 7.4341 (0.9); 7.2967 (3.9); 4.2444 (0.9); 4.1624 (15.6); 4.0647 (16.0); 1.5933 (3.9); 1.2906 (1.1); 0.0346 (3.8)
1-047:1 H-NMR(499.9 MHz, CDCl3): δ= 7.9753 (5.2); 7.6683 (0.6); 7.5512 (0.8); 7.5390 (1.8); 7.5259 (2.2); 7.5122 (1.1); 7.3323 (1.0); 7.3162 (1.8); 7.3001 (0.8); 7.2636 (1.5); 7.0994 (0.4); 4.0289 (16.0); 3.1503 (0.4); 2.9572 (1.4); 2.9112 (0.4); 2.8836 (1.2); -0.0002 (1.2)
1-048:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.2321 (16.0); 7.5551 (8.5); 7.5506 (6.0); 7.5092 (3.4); 7.4888 (6.3); 7.4574 (4.8); 7.4373 (7.6); 7.4173 (3.5); 7.3037 (4.4); 7.3012 (4.4); 7.2836 (3.6); 7.2812 (3.6); 2.5097 (2.3)
1-049:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5658 (1.2); 7.5527 (3.4); 7.5398 (0.3); 7.4911 (1.5); 7.4397 (0.6); 7.4346 (1.1); 7.4303 (0.8); 7.4280 (0.5); 7.4258 (0.5); 7.4218 (0.7); 7.4171 (0.4); 7.2620 (0.9); 4.1764 (0.4); 4.0726 (1.0); 4.0590 (16.0); 3.9974 (0.4); -0.0002 (0.8)
1-050:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.6812 (1.0); 8.6207 (2.3); 8.1045 (0.6); 8.1000 (1.0); 8.0954 (0.6); 7.7447 (0.5); 7.7179 (1.0); 7.6933 (0.6); 7.6318 (0.4); 7.2260 (0.8); 5.2581 (0.4); 5.2373 (0.5); 5.2165 (0.4); 3.3506 (16.0); 2.5342 (1.0); 2.5283 (2.2); 2.5222 (3.0); 2.5162 (2.1); 2.5102 (1.0); 1.3599 (5.9); 1.3391 (5.8); 0.0194 (0.8)
1-051:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.3714 (6.2); 8.3653 (6.3); 8.3270 (6.0); 8.3186 (6.1); 8.2572 (16.0); 7.4202 (3.8); 7.4128 (6.0); 7.4055 (3.8); 5.7785 (1.2); 3.4711 (0.4); 3.4031 (0.5); 3.3840 (0.5); 3.2446 (0.4); 2.5341 (4.0); 2.5282 (8.4); 2.5222 (11.5); 2.5162 (8.4); 2.5103 (4.1); 2.0860 (0.6); 2.0692 (1.3); 2.0578 (1.5); 2.0412 (2.7); 2.0246 (1.6); 2.0132 (1.6); 1.9965 (0.8); 1.1944 (0.4); 1.0786 (1.6); 1.0637 (4.4); 1.0562 (5.0); 1.0424 (2.7); 1.0356 (4.6); 1.0281 (4.5); 1.0146 (2.0); 0.8207 (2.0); 0.8066 (5.2); 0.7998 (5.3); 0.7903 (4.9); 0.7833 (5.6); 0.7678 (1.6); 0.0306 (0.4); 0.0197 (10.2); 0.0086 (0.5)
1-052:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5717 (0.3); 7.5706 (0.3); 7.5562 (1.2); 7.5436 (3.3); 7.4786 (1.5); 7.4294 (0.6); 7.4239 (1.1); 7.4197 (0.8); 7.4157 (0.5); 7.4107 (0.7); 7.4065 (0.4); 7.2606 (2.2); 4.1428 (0.3); 4.0748 (1.1); 4.0582 (16.0); 3.9978 (0.3); 1.5556 (2.7); -0.0002 (2.2)
1-053:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.9232 (0.6); 8.8705 (5.1); 8.7368 (2.9); 8.7204 (3.0); 8.4955 (7.6); 8.2803 (0.8); 7.7880 (2.9); 7.7717 (2.8); 7.5349 (0.5); 7.5222 (0.6); 7.5125 (0.7); 7.5007 (1.1); 7.4928 (0.7); 7.4881 (0.7); 7.4767 (1.1); 7.4667 (0.8); 7.4573 (0.6); 7.4433 (0.6); 7.4263 (0.5); 7.4155 (0.5); 7.3993 (3.2); 7.3863 (3.8); 7.3754 (2.0); 7.3637 (1.0); 7.3344 (0.4); 4.0845 (0.6); 4.0607 (1.8); 4.0370 (1.9); 4.0133 (0.7); 3.3635 (0.5); 3.1890 (0.3); 2.5342 (2.7); 2.5284 (5.7); 2.5224 (7.9); 2.5164 (5.9); 2.5106 (3.0); 2.0085 (8.3); 1.9293 (3.1); 1.2178 (2.2); 1.1941 (4.2); 1.1704 (2.1); 1.0893 (16.0); 0.0186 (4.4)
1-054:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.0517 (0.4); 7.7345 (1.3); 7.7085 (3.8); 7.6823 (4.2); 7.6629 (4.6); 7.6369 (2.0); 7.5787 (4.9); 7.5312 (3.5); 7.5052 (2.6); 7.4437 (0.6); 7.4262 (0.6); 7.4087 (0.8); 7.2862 (0.4); 7.1165 (0.4); 4.0613 (0.7); 4.0376 (0.7); 3.3468 (0.5); 3.1893 (0.3); 2.9676 (2.1); 2.9428 (6.4); 2.9179 (6.5); 2.8932 (2.2); 2.5344 (4.8); 2.5285 (9.6); 2.5224 (12.8); 2.5164 (9.0); 2.5107 (4.0); 2.3794 (1.5); 2.3375 (25.8); 2.0950 (0.5); 2.0091 (2.8); 1.2909 (7.8); 1.2661 (16.0); 1.2413 (7.2); 1.2184 (0.8); 1.1947 (1.5); 1.1709 (0.7); 0.0304 (0.7); 0.0196 (13.8); 0.0086 (0.4); -0.0406 (1.0)
1-055:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5959 (0.6); 7.5745 (1.0); 7.5523 (0.6); 7.5012 (0.5); 7.4763 (1.2); 7.4523 (0.8); 7.3728 (1.0); 7.3476 (1.2); 7.3198 (0.5); 7.2988 (7.5); 7.1046 (0.9); 6.9353 (0.6); 6.9223 (1.9); 6.7399 (0.9); 4.1162 (3.5); 4.1049 (16.0); 4.0922 (1.0); 4.0670 (0.6); 4.0386 (0.3); 1.6176 (0.4); 1.5935 (5.8); 1.3870 (0.4); 1.2929 (0.4); 0.1077 (2.1); 0.0374 (6.9); 0.0265 (0.3)
1-056:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9045 (4.4); 7.4588 (0.3); 7.4443 (0.4); 7.4349 (2.3); 7.4061 (2.6); 7.3729 (0.4); 7.3508 (1.9); 7.3245 (4.0); 7.2984 (19.6); 7.0244 (4.2); 7.0162 (3.3); 7.0044 (3.0); 6.9980 (3.2); 6.9899 (2.2); 6.9865 (2.2); 6.9762 (1.3); 6.9373 (2.6); 6.9311 (3.2); 6.9243 (1.8); 6.8304 (1.8); 6.8210 (1.6); 6.8080 (0.4); 4.5949 (0.7); 4.5870 (2.4); 4.5817 (0.8); 4.5632 (7.1); 4.5394 (7.2); 4.5313 (1.5); 4.5157 (2.6); 4.5074 (3.3); 4.4836 (3.2); 4.4598 (1.1); 2.2702 (0.4); 2.2594 (0.4); 2.2419 (0.8); 2.2255 (0.4); 2.2138 (0.4); 1.9860 (0.4); 1.9691 (0.9); 1.9578 (1.0); 1.9412 (1.8); 1.9245 (1.1); 1.9132 (1.0); 1.8962 (0.5); 1.6190 (0.3); 1.5864 (14.6); 1.5204 (0.6); 1.4963 (1.6); 1.4869 (8.1); 1.4787 (4.3); 1.4721 (2.3); 1.4631 (16.0); 1.4550 (7.8); 1.4485 (1.6); 1.4394 (7.8); 1.4312 (3.7); 1.3021 (1.3); 1.2969 (1.0); 1.2736 (0.4); 1.0913 (0.7); 1.0756 (1.7); 1.0697 (1.7); 1.0634 (1.1); 1.0544 (1.3); 1.0460 (2.6); 1.0416 (2.0); 1.0301 (3.3); 1.0234 (3.6); 1.0083 (2.0); 1.0017 (3.3); 0.9951 (2.8); 0.9804 (1.5); 0.7653 (1.6); 0.7499 (4.0); 0.7436 (3.8); 0.7334 (3.7); 0.7272 (5.4); 0.7112 (2.4); 0.7039 (2.1); 0.6872 (0.6); 0.1081 (0.4); 0.0488 (0.8); 0.0381 (17.7); 0.0272 (0.7)
1-057:1 H-NMR(300.2 MHz, CDCl3): δ= 8.4033 (16.0); 7.6856 (0.8); 7.6598 (4.2); 7.6407 (10.8); 7.6374 (10.2); 7.5838 (5.3); 7.5494 (0.9); 7.5427 (0.8); 7.5336 (2.2); 7.5228 (3.1); 7.5156 (2.8); 7.5028 (2.2); 7.4954 (1.5); 7.3906 (0.4); 7.3742 (0.4); 7.3606 (0.3); 7.2986 (62.6); 6.9476 (0.3); 5.0308 (0.4); 4.0812 (0.5); 3.8943 (0.6); 3.8725 (0.7); 3.7159 (1.1); 3.6788 (1.7); 3.6611 (1.0); 3.5391 (0.7); 3.4838 (0.4); 3.4479 (0.3); 3.2596 (0.4); 3.2174 (1.2); 3.1656 (0.6); 3.0881 (0.6); 3.0787 (0.6); 3.0061 (0.4); 2.9309 (1.1); 2.1975 (0.9); 2.0977 (0.7); 1.4829 (0.4); 1.4699 (2.7); 1.4486 (0.3); 1.4286 (0.3); 1.3620 (0.4); 1.2922 (3.3); 1.2760 (0.8); 1.2506 (0.5); 0.9162 (0.4); 0.1071 (14.1); 0.0947 (0.6); 0.0479 (2.0); 0.0372 (44.4); 0.0263 (1.8)
1-058:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8995 (5.5); 7.5887 (0.6); 7.2987 (3.4); 7.1384 (0.3); 7.1201 (1.3); 7.1163 (1.4); 7.1109 (2.2); 7.0931 (3.4); 7.0661 (0.3); 6.8539 (0.6); 6.8451 (0.7); 6.8314 (1.0); 6.8215 (0.8); 6.8166 (1.1); 6.8003 (0.4); 5.4035 (0.4); 5.3827 (1.0); 5.3618 (1.4); 5.3409 (1.0); 5.3201 (0.4); 2.1478 (0.4); 2.1369 (0.5); 2.1304 (0.4); 2.1196 (0.9); 2.1087 (0.4); 2.1021 (0.6); 2.0914 (0.5); 1.6022 (2.8); 1.4751 (1.8); 1.4579 (16.0); 1.4371 (15.5); 1.0643 (0.7); 1.0492 (1.6); 1.0423 (1.7); 1.0362 (0.9); 1.0329 (0.7); 1.0275 (1.2); 1.0206 (1.8); 1.0138 (1.6); 0.9993 (0.9); 0.8139 (0.8); 0.7990 (1.9); 0.7929 (1.8); 0.7818 (1.8); 0.7764 (1.9); 0.7645 (0.6); 0.7597 (0.9); 0.7476 (0.4); 0.7418 (0.4); 0.0381 (3.4)
1-059:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2245 (5.3); 7.6379 (1.1); 7.6167 (3.3); 7.5953 (0.4); 7.5685 (1.5); 7.5201 (0.7); 7.5109 (1.1); 7.5036 (0.7); 7.4971 (0.4); 7.4889 (0.6); 7.4819 (0.4); 7.2985 (6.2); 5.4415 (0.4); 5.4205 (1.0); 5.3996 (1.4); 5.3788 (1.0); 5.3580 (0.4); 4.0917 (0.4); 2.9951 (0.5); 2.9228 (0.4); 1.5930 (1.9); 1.4811 (16.0); 1.4602 (15.9); 0.1074 (0.9); 0.0368 (5.0)
1-060:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5495 (1.9); 7.5340 (7.4); 7.5182 (13.7); 7.4997 (2.3); 7.4695 (10.2); 7.4209 (5.8); 7.4062 (4.7); 7.3878 (0.6); 7.2606 (11.5); 5.2971 (0.7); 4.5407 (0.6); 4.5266 (1.8); 4.5125 (2.4); 4.5021 (5.8); 4.4879 (16.0); 4.4736 (15.8); 4.4594 (5.2); 4.3889 (5.0); 4.3749 (15.5); 4.3610 (15.6); 4.3471 (5.2); 1.5548 (14.0); 1.5088 (16.0); 1.4948 (31.9); 1.4808 (15.7); 1.4563 (2.0); 1.4497 (2.1); 1.4423 (4.0); 1.4354 (3.9); 1.4214 (17.8); 1.4071 (32.0); 1.3928 (15.8); 1.2776 (0.4); 1.2571 (1.2); -0.0002 (11.5)
1-061:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8527 (4.8); 7.8448 (0.7); 7.4713 (1.5); 7.3465 (0.9); 7.3329 (0.6); 7.3203 (1.7); 7.3065 (0.4); 7.2983 (1.8); 7.2940 (1.3); 7.0217 (1.2); 7.0137 (1.9); 7.0082 (1.4); 6.9977 (1.0); 6.9945 (1.0); 6.9866 (1.6); 6.9832 (1.3); 6.9467 (1.3); 6.9404 (1.7); 6.9331 (1.1); 6.9253 (0.5); 5.3803 (0.4); 5.3706 (0.3); 5.3595 (1.0); 5.3497 (0.4); 5.3387 (1.3); 5.3309 (0.7); 5.3178 (1.0); 5.2970 (0.4); 1.9690 (0.5); 1.9576 (0.5); 1.9410 (0.9); 1.9242 (0.5); 1.9131 (0.5); 1.6409 (2.4); 1.4629 (2.6); 1.4591 (4.6); 1.4361 (16.0); 1.4151 (14.5); 1.4033 (0.6); 1.3822 (0.4); 1.0347 (0.9); 1.0296 (0.6); 1.0194 (1.5); 1.0125 (1.7); 1.0096 (1.3); 0.9978 (1.0); 0.9910 (1.6); 0.9847 (1.4); 0.9697 (0.8); 0.7664 (0.9); 0.7513 (2.3); 0.7453 (2.0); 0.7348 (1.8); 0.7290 (2.4); 0.7126 (0.7); 0.0368 (1.6)
1-062:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.3065 (16.0); 8.1039 (1.2); 7.7140 (1.2); 7.6870 (2.5); 7.6596 (1.8); 7.6421 (1.3); 7.6195 (2.5); 7.5986 (1.6); 7.4977 (2.4); 7.4826 (3.1); 7.4711 (3.4); 7.4442 (1.3); 7.3027 (5.4); 7.1228 (2.7); 4.0602 (1.0); 4.0365 (1.0); 4.0127 (0.4); 3.4910 (0.3); 2.5341 (3.0); 2.5282 (6.4); 2.5221 (8.9); 2.5160 (6.6); 2.5101 (3.2); 2.0087 (4.4); 1.9291 (1.1); 1.2176 (1.2); 1.1939 (2.4); 1.1701 (1.2); 1.1561 (0.5); 0.0186 (9.5); 0.0076 (0.5); -0.0425 (2.0)
1-063:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.7017 (1.3); 8.6952 (1.5); 8.6861 (6.0); 8.6850 (5.6); 8.6797 (6.3); 8.6674 (1.4); 8.6596 (1.4); 8.6268 (5.9); 8.6189 (6.2); 8.3059 (16.0); 8.2818 (0.9); 8.2749 (1.4); 8.2674 (0.8); 8.2297 (4.5); 8.2230 (6.4); 8.2154 (4.1); 8.1457 (0.4); 8.0647 (0.3); 8.0472 (3.3); 5.7778 (0.4); 4.0597 (0.5); 4.0360 (0.4); 3.1873 (0.4); 2.5611 (14.4); 2.5339 (3.5); 2.5279 (7.4); 2.5218 (10.0); 2.5158 (7.2); 2.5099 (3.3); 2.0085 (1.8); 1.9286 (1.0); 1.2173 (0.5); 1.1936 (1.0); 1.1698 (0.5); 0.0294 (0.5); 0.0186 (13.5); 0.0093 (0.4); 0.0076 (0.5)
1-064:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6140 (0.6); 7.5922 (1.2); 7.5698 (1.5); 7.5467 (0.7); 7.3813 (0.7); 7.3551 (1.0); 7.3275 (0.4); 7.2990 (6.7); 4.1179 (2.2); 4.1089 (16.0); 1.6002 (1.0); 1.2938 (0.6); 1.2737 (0.9); 1.2678 (0.4); 0.9187 (0.4); 0.0367 (6.7)
1-065:1 H-NMR(300.2 MHz, CDCl3): δ= 7.2986 (6.2); 7.1237 (0.4); 7.1045 (1.4); 7.0965 (2.2); 7.0911 (2.7); 7.0769 (1.8); 7.0728 (2.5); 7.0454 (0.5); 6.8423 (0.3); 6.8363 (0.7); 6.8284 (0.8); 6.8208 (0.5); 6.8141 (1.1); 6.8033 (0.8); 6.7976 (0.8); 6.7828 (0.5); 5.8161 (0.4); 5.4585 (0.4); 5.4377 (1.0); 5.4168 (1.4); 5.3959 (1.1); 5.3751 (0.4); 2.6527 (8.2); 2.4601 (15.6); 2.4508 (2.3); 2.1444 (0.5); 2.1331 (0.6); 2.1162 (1.0); 2.0996 (0.7); 2.0878 (0.6); 2.0711 (0.3); 1.6184 (0.6); 1.4808 (1.7); 1.4701 (0.6); 1.4552 (16.0); 1.4343 (15.6); 1.4130 (0.5); 1.3921 (0.4); 1.2935 (0.4); 1.0594 (0.8); 1.0441 (1.9); 1.0373 (2.0); 1.0312 (1.4); 1.0226 (1.5); 1.0155 (2.0); 1.0091 (1.8); 0.9945 (1.1); 0.8051 (1.0); 0.7901 (2.2); 0.7840 (2.1); 0.7732 (2.0); 0.7670 (2.3); 0.7574 (0.7); 0.7509 (0.8); 0.7410 (0.5); 0.1079 (1.1); 0.0374 (5.2)
1-066:1 H-NMR(499.9 MHz, CDCl3): δ= 8.1443 (5.2); 7.5649 (0.5); 7.5494 (1.7); 7.5338 (2.0); 7.5254 (2.4); 7.5099 (0.9); 7.4936 (2.5); 7.4298 (1.5); 7.4146 (1.2); 7.2672 (0.5); 5.3302 (0.5); 5.3177 (1.2); 5.3052 (1.6); 5.2927 (1.2); 5.2802 (0.5); 1.6345 (0.4); 1.4002 (15.4); 1.3876 (16.0); -0.0002 (0.5)
1-067:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 8.0179 (6.6); 7.7953 (0.7); 7.7804 (1.4); 7.7656 (0.8); 7.7208 (0.7); 7.7069 (1.2); 7.6936 (0.8); 7.5189 (1.0); 7.5027 (1.6); 7.4865 (0.7); 2.6214 (16.0); 2.5058 (0.4); 1.3515 (0.9)
1-068:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5329 (0.7); 7.5066 (2.3); 7.4812 (1.9); 7.4459 (2.0); 7.4053 (2.3); 7.3599 (1.4); 7.3323 (1.0); 7.3067 (6.2); 5.5646 (0.3); 5.3280 (0.5); 5.3072 (1.1); 5.2864 (1.5); 5.2656 (1.1); 5.2448 (0.5); 2.6875 (0.5); 2.6772 (0.8); 2.6664 (1.0); 2.6556 (0.8); 2.6452 (0.6); 1.4524 (1.3); 1.4316 (1.4); 1.3492 (16.0); 1.3284 (16.0); 1.2987 (0.9); 0.9515 (0.6); 0.9288 (2.4); 0.9120 (2.5); 0.8904 (0.8); 0.6958 (0.8); 0.6800 (2.2); 0.6733 (2.6); 0.6461 (0.6); 0.0441 (6.0)
1-069:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5879 (2.7); 7.5816 (2.7); 7.5680 (4.8); 7.5440 (1.0); 7.5233 (2.8); 7.4797 (1.5); 7.4738 (1.8); 7.4668 (1.3); 7.4568 (1.2); 7.4512 (1.3); 7.3127 (0.4); 7.3003 (1.4); 7.2951 (2.7); 6.8372 (0.6); 6.8321 (1.1); 6.7932 (1.5); 6.7782 (0.7); 6.7731 (1.3); 6.7491 (0.5); 6.7393 (0.8); 6.7342 (1.5); 6.3408 (0.5); 6.2819 (0.4); 5.9556 (1.8); 5.9503 (2.7); 5.9177 (0.9); 5.8952 (3.8); 5.8562 (2.3); 4.0582 (2.1); 4.0531 (3.5); 4.0245 (2.2); 4.0128 (8.4); 4.0078 (16.0); 1.6205 (0.5); 1.6087 (2.0); 1.6040 (3.6); 0.0493 (0.4); 0.0377 (1.3); 0.0326 (2.6)
1-070:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 7.7089 (0.7); 7.6892 (2.0); 7.6694 (1.7); 7.6395 (2.0); 7.6200 (1.1); 7.5614 (2.6); 7.5153 (1.4); 7.4954 (1.1); 2.5592 (16.4); 2.5156 (2.0); 2.5112 (4.2); 2.5069 (5.7); 2.5024 (4.1); 2.4983 (2.0); 2.3154 (0.5); 2.3022 (16.0); 0.0008 (4.3)
1-071:1 H-NMR(300.2 MHz, CDCl3): δ= 8.0795 (5.2); 8.0524 (0.7); 8.0253 (1.4); 7.9997 (0.8); 7.5587 (1.8); 7.5339 (1.6); 7.4377 (1.6); 7.4100 (1.4); 7.2985 (4.0); 5.3364 (0.5); 4.0608 (0.7); 3.8576 (16.0); 3.1416 (0.5); 1.6031 (4.4); 0.1054 (0.8); 0.0349 (3.5)
1-072:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2043 (5.1); 7.5859 (1.0); 7.5595 (2.0); 7.5517 (1.6); 7.5471 (1.5); 7.5332 (2.0); 7.4915 (0.8); 7.4854 (1.1); 7.4788 (0.6); 7.4604 (0.6); 7.2986 (5.3); 5.6409 (2.3); 5.6325 (2.4); 5.4040 (0.4); 5.3831 (1.0); 5.3623 (1.4); 5.3414 (1.0); 5.3205 (0.4); 4.5051 (2.0); 4.4967 (2.0); 4.0863 (0.9); 4.0630 (3.0); 4.0397 (3.1); 4.0164 (1.0); 1.5943 (5.2); 1.5232 (3.4); 1.5000 (7.1); 1.4767 (3.4); 1.4479 (16.0); 1.4270 (15.8); 1.4090 (0.3); 1.3594 (0.3); 0.9838 (0.4); 0.9596 (0.8); 0.9353 (0.3); 0.1073 (0.3); 0.0366 (5.2)
1-073:1 H-NMR(300.2 MHz, CDCl3): δ= 7.2988 (4.3); 7.1128 (1.7); 7.1047 (2.2); 7.1007 (1.8); 7.0872 (3.4); 6.8630 (0.6); 6.8544 (0.6); 6.8408 (1.0); 6.8275 (0.7); 6.8096 (0.4); 5.4799 (0.4); 5.4591 (1.0); 5.4382 (1.3); 5.4173 (1.0); 5.3964 (0.4); 2.1481 (0.4); 2.1370 (0.5); 2.1198 (0.8); 2.1026 (0.5); 2.0916 (0.4); 1.6711 (0.8); 1.6615 (0.8); 1.4937 (1.8); 1.4714 (16.0); 1.4505 (14.9); 1.0727 (0.6); 1.0574 (1.7); 1.0507 (1.7); 1.0447 (0.9); 1.0358 (1.0); 1.0288 (1.8); 1.0222 (1.5); 1.0076 (0.7); 0.8119 (0.8); 0.7969 (1.9); 0.7906 (1.9); 0.7799 (1.7); 0.7741 (1.9); 0.7577 (0.6); 0.1078 (0.4); 0.0371 (4.0)
1-074:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.8704 (1.4); 8.7420 (0.8); 8.7256 (0.9); 8.5221 (1.8); 7.7842 (0.8); 7.7678 (0.8); 7.5120 (0.3); 7.5003 (0.5); 7.4760 (0.4); 7.4015 (0.9); 7.3882 (1.1); 7.3775 (0.7); 7.3634 (0.4); 5.2782 (0.4); 5.2574 (0.5); 5.2366 (0.4); 3.5844 (11.6); 3.3825 (10.1); 2.5285 (0.7); 2.5227 (1.0); 2.5168 (0.7); 2.0055 (0.6); 1.3829 (5.1); 1.3621 (5.1); 1.3484 (0.8); 1.1907 (0.4); 1.1746 (1.4); 1.0877 (16.0); 0.8961 (1.1); 0.0127 (0.4)
1-075:1 H-NMR(300.2 MHz, CDCl3): δ= 8.5413 (5.4); 7.6421 (1.0); 7.6171 (2.8); 7.6120 (1.5); 7.5933 (0.4); 7.5691 (1.4); 7.5270 (0.6); 7.5198 (1.1); 7.5126 (0.6); 7.5054 (0.4); 7.5027 (0.4); 7.4969 (0.6); 7.4894 (0.3); 7.2986 (3.4); 5.4233 (0.4); 5.4024 (1.0); 5.3815 (1.3); 5.3606 (1.0); 5.3398 (0.4); 2.8540 (16.0); 2.0810 (0.9); 1.6089 (0.5); 1.4674 (15.9); 1.4465 (15.4); 1.4330 (0.5); 1.4068 (0.4); 1.3808 (0.3); 1.3581 (0.6); 1.3309 (0.4); 1.3048 (0.3); 1.2945 (0.7); 0.9818 (0.7); 0.9576 (1.4); 0.9333 (0.6); 0.0342 (3.1)
1-076:1 H-NMR(300.2 MHz, CDCl3): δ= 8.3788 (3.8); 8.3722 (4.6); 8.3691 (4.7); 8.3603 (4.0); 8.1750 (0.6); 7.9458 (10.8); 7.6031 (0.9); 7.2985 (17.2); 7.2701 (0.3); 7.2603 (2.2); 7.2527 (3.3); 7.2456 (2.0); 4.5467 (2.3); 4.5362 (0.8); 4.5229 (7.4); 4.5124 (0.9); 4.4991 (7.5); 4.4887 (0.4); 4.4754 (2.5); 2.0339 (0.4); 2.0171 (0.9); 2.0060 (0.9); 1.9891 (1.8); 1.9723 (1.0); 1.9610 (1.0); 1.9440 (0.5); 1.5607 (0.4); 1.5079 (1.0); 1.4892 (7.9); 1.4841 (2.1); 1.4654 (16.0); 1.4417 (7.6); 1.1307 (1.2); 1.1149 (2.8); 1.1085 (3.1); 1.0927 (1.9); 1.0863 (3.0); 1.0805 (2.6); 1.0648 (1.4); 0.8200 (1.4); 0.8039 (3.9); 0.7989 (3.1); 0.7874 (3.0); 0.7820 (3.9); 0.7653 (1.1); 0.1053 (3.9); 0.0463 (0.6); 0.0355 (18.2); 0.0246 (0.7)
1-077:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.6152 (2.2); 7.5083 (0.4); 7.4466 (2.6); 7.2777 (2.1); 7.1794 (1.4); 7.1521 (4.7); 7.1336 (5.7); 7.1190 (2.6); 7.0996 (0.7); 6.9334 (1.5); 6.9177 (2.0); 6.9113 (1.8); 6.9031 (2.2); 6.8872 (1.4); 6.8798 (1.0); 6.5450 (0.4); 3.5192 (0.8); 3.3841 (16.0); 2.5659 (2.3); 2.5519 (24.4); 2.5343 (11.2); 2.5284 (22.7); 2.5224 (31.2); 2.5163 (25.9); 2.3835 (0.5); 2.3446 (3.6); 2.3112 (24.3); 2.2623 (0.3); 2.1990 (0.7); 2.1033 (1.8); 2.0950 (2.1); 2.0887 (1.2); 2.0781 (1.2); 2.0605 (2.0); 2.0434 (1.3); 2.0330 (1.1); 2.0154 (0.6); 2.0058 (0.8); 1.9291 (1.3); 1.3718 (1.0); 1.3550 (1.7); 1.3341 (1.7); 1.2897 (0.4); 1.2524 (0.7); 1.1846 (1.9); 1.0513 (1.4); 1.0365 (4.0); 1.0292 (4.3); 1.0157 (2.7); 1.0084 (4.1); 1.0012 (4.0); 0.9880 (1.7); 0.9641 (0.3); 0.8043 (1.8); 0.7905 (4.7); 0.7840 (4.7); 0.7738 (4.7); 0.7672 (4.4); 0.7517 (1.5); 0.0632 (0.5); 0.0269 (0.4); 0.0161 (12.2); 0.0049 (0.6); -0.0478 (2.8)
1-078:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3272 (0.5); 7.2987 (3.5); 7.2747 (0.8); 7.0122 (0.4); 7.0093 (0.6); 7.0044 (0.5); 7.0015 (0.7); 6.9863 (0.9); 6.9775 (0.5); 6.9744 (0.6); 6.9627 (0.7); 6.9354 (0.8); 6.9290 (1.0); 6.9223 (0.5); 5.4152 (0.6); 5.3943 (0.8); 5.3735 (0.6); 2.6494 (16.0); 2.4422 (8.7); 1.9302 (0.6); 1.6585 (0.4); 1.4341 (8.6); 1.4132 (8.7); 1.3939 (0.4); 1.3869 (0.4); 1.0290 (0.4); 1.0139 (1.0); 1.0070 (1.0); 1.0013 (0.5); 0.9921 (0.6); 0.9855 (1.0); 0.9789 (0.8); 0.9642 (0.4); 0.7569 (0.5); 0.7418 (1.2); 0.7355 (1.0); 0.7254 (1.0); 0.7195 (1.2); 0.7032 (0.4); 0.0355 (3.1)
1-079:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.3115 (5.9); 7.7517 (0.6); 7.7318 (2.1); 7.7143 (3.6); 7.6877 (2.5); 7.6688 (1.2); 7.6300 (1.8); 7.6098 (1.2); 3.9368 (16.0); 3.3278 (5.3); 2.5097 (0.8)
1-080:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3109 (0.8); 7.2987 (4.7); 7.2848 (1.4); 7.2586 (0.9); 7.0014 (0.6); 6.9984 (0.7); 6.9936 (0.8); 6.9906 (0.8); 6.9709 (1.1); 6.9665 (1.4); 6.9405 (0.8); 6.9259 (1.1); 6.9195 (1.2); 6.9129 (0.6); 5.4044 (0.7); 5.3835 (0.9); 5.3626 (0.7); 3.7427 (16.0); 2.6631 (0.6); 2.6431 (9.0); 2.3405 (9.2); 2.2666 (0.4); 2.0823 (0.5); 1.9509 (0.3); 1.9398 (0.4); 1.9229 (0.7); 1.9061 (0.4); 1.8950 (0.4); 1.4311 (0.4); 1.4202 (11.0); 1.3993 (10.9); 1.2954 (0.5); 1.0104 (0.5); 0.9954 (1.1); 0.9883 (1.3); 0.9826 (0.7); 0.9736 (0.7); 0.9669 (1.2); 0.9600 (1.1); 0.9457 (0.6); 0.7549 (0.6); 0.7399 (1.4); 0.7334 (1.3); 0.7234 (1.2); 0.7176 (1.5); 0.7012 (0.5); 0.4732 (1.4); 0.3153 (2.9); 0.1064 (0.4); 0.0358 (4.7)
1-081:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 12.4164 (0.4); 9.3565 (0.4); 7.3562 (6.8); 7.3301 (15.4); 7.3039 (9.4); 7.2752 (0.9); 7.2503 (0.5); 7.0529 (0.5); 7.0373 (0.6); 7.0158 (9.1); 7.0118 (8.1); 6.9860 (12.4); 6.9779 (9.5); 6.9750 (8.0); 6.9596 (4.6); 6.9562 (5.0); 6.9515 (10.2); 6.9483 (9.1); 6.9417 (13.6); 6.9361 (14.8); 6.9295 (7.4); 6.8903 (1.2); 6.5383 (0.3); 6.5193 (0.6); 6.4942 (0.4); 6.4631 (0.5); 6.4561 (0.6); 6.4496 (0.3); 4.0848 (0.3); 4.0611 (1.0); 4.0374 (1.0); 4.0135 (0.4); 3.0156 (0.9); 2.6205 (0.4); 2.5614 (5.1); 2.5342 (6.9); 2.5281 (14.7); 2.5221 (20.4); 2.5160 (15.0); 2.5100 (7.3); 2.4708 (0.5); 2.4047 (94.7); 2.3577 (1.4); 2.3372 (0.6); 2.2181 (6.5); 2.1853 (0.6); 2.0997 (4.5); 2.0161 (1.7); 2.0089 (4.6); 1.9993 (3.6); 1.9882 (3.9); 1.9830 (2.9); 1.9716 (7.4); 1.9600 (3.2); 1.9548 (4.5); 1.9437 (4.5); 1.9296 (14.1); 1.8218 (0.4); 1.2184 (1.1); 1.1947 (2.2); 1.1709 (1.1); 1.0134 (4.4); 0.9989 (12.5); 0.9913 (14.0); 0.9857 (7.6); 0.9777 (8.1); 0.9708 (14.0); 0.9632 (13.4); 0.9499 (6.6); 0.9355 (0.9); 0.9262 (1.3); 0.9182 (0.9); 0.8977 (1.0); 0.8900 (0.7); 0.8770 (0.4); 0.7850 (0.5); 0.7674 (0.5); 0.7347 (5.6); 0.7208 (14.0); 0.7178 (11.9); 0.7138 (15.0); 0.7042 (14.3); 0.6973 (16.0); 0.6822 (5.6); 0.6626 (0.8); 0.6504 (0.6); 0.6350 (0.5); 0.6291 (0.5); 0.6155 (0.8); 0.6083 (0.8); 0.5988 (0.8); 0.5915 (0.8); 0.5770 (0.3); 0.1053 (0.5); 0.0306 (0.7); 0.0198 (22.5); 0.0088 (1.0); -0.0406 (1.4)
1-082:1 H-NMR(400.1 MHz, CDCl3): δ= 7.5310 (0.4); 7.5109 (1.2); 7.4911 (1.8); 7.4829 (1.9); 7.4692 (2.3); 7.4189 (1.2); 7.3997 (0.7); 7.2594 (7.0); 3.9970 (16.0); 2.6349 (13.6); 2.3177 (13.5); 1.5482 (6.2); -0.0002 (6.0)
1-083:1 H-NMR(499.9 MHz, CDCl3): δ= 7.7555 (5.2); 7.5543 (0.6); 7.5387 (1.5); 7.5229 (1.4); 7.5038 (1.7); 7.4877 (0.9); 7.4753 (1.9); 7.4262 (1.1); 7.4103 (0.8); 7.2609 (3.6); 4.4644 (1.4); 4.4501 (3.9); 4.4359 (3.9); 4.4216 (1.3); 2.6740 (16.0); 1.5512 (1.8); 1.4201 (4.1); 1.4058 (8.0); 1.3915 (3.9); 0.0059 (0.3); -0.0002 (4.2)
1-084:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2471 (2.2); 8.2382 (2.2); 7.8875 (2.2); 7.8822 (2.4); 7.6695 (0.6); 7.6627 (0.6); 7.6517 (0.4); 7.6260 (1.1); 7.6041 (3.5); 7.5820 (0.4); 7.5616 (1.8); 7.5215 (0.8); 7.5123 (1.2); 7.5049 (0.7); 7.4906 (0.7); 7.4833 (0.4); 7.3042 (11.7); 6.6688 (1.5); 6.6627 (1.7); 6.6600 (1.6); 6.6540 (1.4); 6.4075 (0.3); 4.1067 (0.3); 4.0306 (1.6); 3.9255 (16.0); 3.7521 (0.5); 1.6043 (0.4); 0.0536 (0.4); 0.0428 (11.8); 0.0319 (0.4)
1-085:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6203 (1.0); 7.5965 (3.7); 7.5908 (2.4); 7.5804 (2.4); 7.5786 (2.4); 7.5688 (4.0); 7.5603 (3.7); 7.5442 (8.2); 7.5355 (1.8); 7.5333 (1.9); 7.5255 (0.9); 7.5190 (0.7); 7.5166 (0.7); 7.5106 (0.7); 7.5027 (0.4); 7.4599 (0.5); 7.4479 (0.4); 7.4361 (2.1); 7.4283 (2.1); 7.4194 (1.6); 7.4163 (2.0); 7.4110 (1.1); 7.4076 (1.0); 7.4038 (1.3); 7.3014 (3.6); 4.1011 (0.4); 3.7961 (4.1); 3.7421 (16.0); 1.6023 (2.3); 0.0411 (2.9)
1-086:1 H-NMR(400.1 MHz, CDCl3): δ= 8.6013 (3.0); 8.5973 (2.8); 8.5141 (2.8); 8.5086 (2.8); 7.9647 (5.2); 7.8504 (0.4); 7.8267 (1.6); 7.8215 (2.7); 7.8164 (1.6); 7.6276 (0.7); 7.2734 (0.9); 4.0351 (2.5); 4.0229 (16.0); -0.0002 (0.8)
1-087:1 H-NMR(499.9 MHz, CDCl3): δ= 7.5580 (0.4); 7.5425 (1.5); 7.5268 (3.1); 7.5088 (0.6); 7.4751 (2.1); 7.4226 (1.3); 7.4079 (1.0); 7.2602 (3.1); 4.0240 (16.0); 2.4323 (15.4); 1.5511 (4.0); -0.0002 (3.2)
1-088:1 H-NMR(300.2 MHz, CDCl3): δ= 8.8513 (3.1); 8.8181 (2.8); 8.8097 (2.8); 8.0119 (10.8); 7.9514 (0.4); 7.9336 (1.6); 7.9271 (2.8); 7.9205 (1.6); 7.6933 (1.4); 7.2997 (27.9); 4.5816 (0.4); 4.5688 (2.4); 4.5577 (1.1); 4.5450 (7.4); 4.5339 (1.3); 4.5212 (7.5); 4.5100 (0.6); 4.4975 (2.4); 3.1500 (0.6); 1.5927 (10.0); 1.5229 (1.1); 1.5050 (7.9); 1.4992 (2.6); 1.4812 (16.0); 1.4574 (7.6); 0.0494 (1.0); 0.0386 (29.1); 0.0276 (0.9)
1-089:1 H-NMR(300.2 MHz, CDCl3): δ= 10.3815 (3.7); 7.9584 (5.4); 7.8619 (0.6); 7.8561 (0.6); 7.8420 (0.6); 7.8360 (1.2); 7.8300 (0.8); 7.8158 (0.7); 7.8101 (0.7); 7.6472 (0.6); 7.6415 (0.6); 7.6208 (1.1); 7.6162 (1.0); 7.5959 (0.8); 7.5901 (0.7); 7.3977 (0.8); 7.3711 (1.3); 7.3446 (0.6); 7.2985 (2.2); 5.4175 (0.4); 5.3966 (1.0); 5.3757 (1.4); 5.3549 (1.1); 5.3341 (3.7); 1.6217 (1.4); 1.4694 (15.8); 1.4486 (16.0); 1.4290 (0.6); 1.2554 (0.5); 1.2348 (0.5); 1.2138 (0.4); 1.1934 (0.4); 0.0327 (2.7)
1-090:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9090 (5.7); 7.4635 (0.5); 7.4573 (0.5); 7.4388 (0.7); 7.4325 (1.0); 7.4187 (0.6); 7.4101 (0.6); 7.2987 (4.3); 7.2564 (0.4); 7.2358 (1.0); 7.2296 (0.8); 7.2154 (1.2); 7.2085 (2.4); 7.1828 (1.2); 7.1565 (0.4); 6.9290 (0.8); 6.8917 (0.8); 6.8700 (0.9); 6.8327 (0.9); 5.9082 (1.5); 5.9052 (1.6); 5.8492 (1.4); 5.8461 (1.4); 5.4700 (1.5); 5.4669 (1.5); 5.4326 (1.4); 5.4296 (1.5); 5.4042 (0.4); 5.3834 (1.0); 5.3625 (1.4); 5.3417 (1.0); 5.3208 (0.4); 1.5941 (1.2); 1.4579 (16.0); 1.4370 (15.8); 1.2576 (0.4); 1.2371 (0.4); 0.0374 (5.4)
1-091:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9042 (6.5); 7.8828 (0.8); 7.8781 (1.4); 7.8742 (1.0); 7.8317 (1.3); 7.8250 (1.8); 7.8191 (1.2); 7.6000 (1.0); 7.5735 (2.1); 7.5474 (1.4); 7.4917 (1.0); 7.4882 (1.1); 7.4837 (1.0); 7.4803 (1.0); 7.4646 (0.6); 7.4611 (0.6); 7.4567 (0.6); 7.4532 (0.6); 7.2987 (2.1); 5.3974 (0.4); 5.3766 (1.0); 5.3557 (1.4); 5.3333 (3.8); 5.3140 (0.4); 2.6431 (16.0); 1.6372 (1.8); 1.4490 (15.6); 1.4281 (15.4); 1.2518 (0.7); 1.2314 (0.7); 0.0329 (2.6)
1-092:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2774 (16.0); 7.6494 (1.3); 7.6440 (1.5); 7.6200 (2.6); 7.6018 (1.6); 7.5956 (1.5); 7.4034 (1.1); 7.3977 (1.2); 7.3764 (2.7); 7.3719 (2.5); 7.3528 (2.5); 7.3465 (2.0); 7.3256 (3.5); 7.2990 (3.9); 7.2722 (1.3); 6.9157 (2.1); 6.8783 (2.4); 6.8566 (2.6); 6.8192 (2.6); 6.0381 (4.1); 6.0355 (4.2); 5.9792 (3.6); 5.9764 (3.6); 5.5463 (4.2); 5.5439 (4.0); 5.5088 (3.8); 5.5062 (4.0); 4.0604 (0.6); 4.0367 (0.6); 2.5346 (2.0); 2.5287 (4.3); 2.5226 (6.1); 2.5166 (4.5); 2.5107 (2.1); 2.0087 (2.5); 1.9299 (0.4); 1.2176 (0.6); 1.1939 (1.3); 1.1702 (0.6); 0.0183 (5.9)
1-093:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2492 (16.0); 7.9235 (2.0); 7.9194 (3.4); 7.9151 (2.4); 7.8982 (2.5); 7.8938 (4.0); 7.8896 (2.8); 7.8121 (3.8); 7.8053 (5.4); 7.7994 (3.7); 7.6781 (2.8); 7.6514 (6.0); 7.6257 (4.0); 7.5801 (3.0); 7.5765 (3.4); 7.5722 (3.1); 7.5687 (3.0); 7.5530 (1.8); 7.5495 (1.7); 7.5451 (1.8); 7.5416 (1.5); 2.6174 (40.6); 2.5452 (0.4); 2.5346 (2.5); 2.5287 (5.3); 2.5226 (7.3); 2.5166 (5.3); 2.5108 (2.5); 2.0092 (0.5); 0.0197 (6.4)
1-094:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2283 (11.5); 7.8419 (0.8); 7.4747 (1.7); 7.4667 (0.6); 7.4491 (3.9); 7.4231 (2.4); 7.2487 (0.5); 7.2326 (3.6); 7.2059 (2.7); 7.1863 (6.8); 7.1595 (2.1); 7.1523 (1.6); 4.0848 (1.1); 4.0611 (3.4); 4.0374 (3.5); 4.0137 (1.2); 3.3580 (1.2); 3.1347 (1.0); 3.1004 (1.6); 3.0916 (1.1); 3.0667 (1.4); 3.0534 (1.2); 3.0236 (1.0); 2.5346 (5.0); 2.5287 (10.8); 2.5227 (14.8); 2.5167 (10.8); 2.5109 (5.0); 2.0656 (2.2); 2.0476 (1.5); 2.0351 (2.8); 2.0282 (2.6); 2.0200 (1.6); 2.0097 (16.0); 2.0008 (3.4); 1.9886 (1.1); 1.9772 (1.1); 1.9665 (1.2); 1.9296 (14.7); 1.2186 (4.0); 1.1949 (7.8); 1.1711 (3.8); 0.0310 (0.6); 0.0202 (17.6); 0.0092 (0.6)
1-095:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2172 (16.0); 7.8172 (1.1); 7.5335 (0.4); 7.5209 (2.7); 7.5083 (1.1); 7.4950 (5.9); 7.4813 (1.3); 7.4687 (4.0); 7.4323 (0.4); 7.2414 (0.8); 7.2065 (8.3); 7.1989 (5.9); 7.1802 (5.2); 7.1726 (5.8); 7.1660 (6.8); 7.1604 (6.4); 5.7866 (0.5); 5.5279 (0.3); 5.4410 (0.6); 5.2844 (0.6); 4.0613 (0.8); 4.0377 (0.8); 4.0142 (0.4); 3.6447 (0.3); 3.3505 (11.6); 3.2182 (0.8); 3.1169 (0.4); 2.7483 (0.5); 2.5853 (0.4); 2.5346 (21.8); 2.5287 (46.6); 2.5227 (64.6); 2.5167 (46.8); 2.5108 (21.7); 2.2933 (0.4); 2.0100 (3.1); 1.9297 (5.9); 1.7140 (0.4); 1.5738 (1.3); 1.5537 (4.9); 1.5468 (4.9); 1.5277 (1.9); 1.5086 (1.4); 1.4880 (4.7); 1.4816 (5.0); 1.4631 (2.0); 1.3997 (0.4); 1.2828 (0.4); 1.2537 (2.2); 1.2318 (5.2); 1.2236 (6.3); 1.2011 (6.3); 1.1951 (6.3); 1.1713 (2.0); 0.2153 (0.4); 0.0318 (2.5); 0.0208 (76.8); 0.0098 (2.6)
1-096:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8773 (5.0); 7.5112 (0.5); 7.4447 (0.9); 7.4317 (0.3); 7.4179 (1.9); 7.3924 (1.4); 7.2989 (5.8); 7.2244 (0.6); 7.1980 (0.5); 7.1791 (2.4); 7.1725 (2.7); 7.1462 (2.4); 7.1348 (1.8); 7.1302 (1.8); 6.8524 (0.3); 6.7354 (0.5); 5.3906 (0.4); 5.3698 (1.0); 5.3489 (1.4); 5.3280 (1.0); 5.3072 (0.4); 4.8971 (1.1); 2.8573 (0.4); 2.8298 (0.5); 2.8166 (0.6); 2.7896 (0.7); 2.7743 (0.5); 2.7474 (0.6); 1.9123 (0.4); 1.8971 (0.7); 1.8825 (0.6); 1.8724 (0.7); 1.8575 (0.8); 1.8424 (0.4); 1.8327 (0.5); 1.8161 (0.5); 1.7111 (0.4); 1.6977 (0.4); 1.6842 (0.7); 1.6703 (1.0); 1.6563 (0.7); 1.6427 (0.9); 1.6287 (0.8); 1.6157 (0.4); 1.5989 (5.8); 1.4677 (1.6); 1.4435 (16.0); 1.4226 (15.5); 1.3048 (1.4); 0.9417 (0.5); 0.9202 (1.4); 0.8971 (0.6); 0.0381 (7.6); 0.0278 (0.3)
1-097:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8774 (4.8); 7.8763 (4.8); 7.5175 (0.7); 7.4681 (0.7); 7.4420 (1.6); 7.4164 (0.9); 7.2999 (5.3); 7.2987 (5.2); 7.1733 (4.2); 7.1458 (2.4); 7.1188 (1.3); 5.3926 (0.4); 5.3715 (1.0); 5.3635 (0.4); 5.3507 (1.3); 5.3300 (1.2); 5.3091 (0.4); 1.5965 (4.9); 1.5767 (1.5); 1.5715 (1.5); 1.5498 (0.6); 1.5350 (0.6); 1.5130 (1.6); 1.5078 (1.6); 1.4867 (0.7); 1.4693 (2.5); 1.4462 (16.0); 1.4250 (14.6); 1.4046 (0.4); 1.1657 (0.6); 1.1437 (1.7); 1.1387 (2.1); 1.1150 (2.0); 1.1095 (1.8); 1.0871 (0.5); 0.0391 (7.1); 0.0378 (6.9)
1-098:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 7.9623 (6.0); 7.6160 (0.7); 7.5966 (1.6); 7.5764 (1.0); 7.4675 (1.5); 7.4482 (1.1); 7.3796 (3.6); 7.3605 (1.0); 7.3580 (1.0); 7.3551 (0.8); 7.1942 (1.2); 7.0549 (2.5); 6.9157 (1.2); 2.6233 (16.0); 2.5112 (1.7); 2.5069 (3.6); 2.5024 (4.8); 2.4979 (3.4); 2.4936 (1.6); -0.0002 (5.2)
1-099:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 8.3652 (0.5); 8.3013 (6.0); 7.2138 (0.4); 7.2107 (0.5); 7.1975 (1.3); 7.1847 (1.3); 7.1784 (2.3); 7.1627 (2.0); 7.1467 (0.8); 6.9469 (0.8); 6.9441 (0.8); 6.9294 (1.3); 6.9191 (0.7); 6.9151 (0.6); 3.9505 (16.0); 3.9442 (2.6); 3.3320 (0.5); 2.0788 (0.6); 2.0722 (0.6); 2.0621 (1.1); 2.0519 (0.7); 2.0454 (0.6); 1.0310 (0.7); 1.0222 (2.1); 1.0179 (2.3); 1.0095 (1.3); 1.0053 (2.2); 1.0011 (2.2); 0.9928 (0.9); 0.7914 (0.9); 0.7828 (2.5); 0.7792 (2.6); 0.7728 (2.5); 0.7690 (2.6); 0.7599 (0.8)
1-100:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 8.0224 (4.7); 7.1588 (2.4); 7.1510 (1.6); 7.1480 (1.6); 7.1398 (2.7); 6.9293 (0.5); 6.9213 (0.6); 6.9129 (0.9); 6.9049 (0.9); 6.8970 (0.5); 6.8887 (0.4); 3.9282 (16.0); 3.3313 (3.9); 2.6229 (13.6); 2.5126 (1.4); 2.5082 (2.8); 2.5037 (3.8); 2.4992 (2.8); 2.4949 (1.4); 2.0704 (0.5); 2.0622 (0.5); 2.0495 (0.9); 2.0366 (0.6); 2.0285 (0.5); 1.0304 (0.6); 1.0194 (1.7); 1.0139 (1.8); 1.0097 (1.0); 1.0037 (1.0); 0.9983 (1.7); 0.9929 (1.8); 0.9827 (0.7); 0.7902 (0.8); 0.7798 (1.9); 0.7748 (2.1); 0.7671 (1.9); 0.7620 (2.0); 0.7508 (0.6); 0.0000 (2.1)
1-101:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 7.2043 (0.4); 7.1889 (1.2); 7.1841 (1.1); 7.1760 (3.2); 7.1676 (1.3); 7.1591 (2.1); 7.1386 (0.6); 6.9595 (0.7); 6.9548 (0.7); 6.9418 (1.0); 6.9354 (1.0); 6.9272 (0.6); 6.9189 (0.5); 3.9980 (16.0); 3.3447 (16.6); 2.5161 (0.8); 2.5119 (1.6); 2.5075 (2.2); 2.5030 (1.6); 2.4028 (14.4); 2.0802 (0.8); 2.0755 (0.5); 2.0671 (0.5); 2.0545 (1.0); 2.0417 (0.6); 2.0335 (0.5); 1.0366 (0.6); 1.0256 (1.8); 1.0201 (2.0); 1.0158 (1.0); 1.0099 (1.0); 1.0045 (1.9); 0.9991 (1.9); 0.9889 (0.8); 0.7930 (0.8); 0.7825 (2.1); 0.7800 (1.9); 0.7775 (2.2); 0.7699 (2.0); 0.7648 (2.2); 0.7535 (0.6); 0.0000 (1.1)
1-102:1 H-NMR(300.2 MHz, CDCl3): δ= 8.7280 (1.2); 8.7058 (1.4); 7.9581 (5.4); 7.8378 (1.4); 7.2988 (5.6); 6.9909 (0.9); 6.8055 (1.9); 6.6200 (1.0); 5.4140 (0.4); 5.3931 (1.0); 5.3722 (1.4); 5.3514 (1.0); 5.3305 (0.4); 1.6191 (3.5); 1.4842 (0.5); 1.4636 (16.0); 1.4427 (15.5); 1.3423 (0.4); 1.3024 (2.4); 0.9393 (0.9); 0.9176 (2.7); 0.8943 (1.0); 0.1059 (1.1); 0.0355 (6.8)
1-103:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 7.4511 (1.2); 7.4315 (2.6); 7.4117 (1.6); 7.2106 (2.1); 7.1913 (1.8); 7.1592 (3.0); 7.1422 (1.9); 7.1219 (1.5); 5.3106 (0.5); 5.2949 (1.2); 5.2793 (1.6); 5.2638 (1.2); 5.2482 (0.5); 3.3097 (8.2); 3.1096 (0.6); 3.0851 (1.0); 3.0578 (0.8); 3.0503 (0.9); 3.0261 (0.6); 2.5093 (4.8); 2.3947 (14.7); 2.0352 (1.3); 2.0099 (2.1); 1.9891 (2.1); 1.9644 (1.2); 1.3721 (0.4); 1.3553 (0.6); 1.3341 (16.0); 1.3186 (15.7)
1-104:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.5079 (5.9); 7.4818 (13.3); 7.4555 (8.1); 7.1921 (9.6); 7.1665 (14.2); 7.1621 (16.0); 7.1403 (4.8); 7.1352 (9.6); 7.1228 (13.0); 7.1168 (15.1); 4.0615 (0.7); 4.0382 (0.7); 4.0142 (0.4); 3.8911 (0.3); 3.8778 (0.3); 3.8051 (0.3); 3.6746 (0.5); 3.6270 (0.8); 3.6045 (0.9); 3.5980 (0.9); 3.3483 (4.0); 3.0543 (0.6); 3.0361 (0.6); 3.0206 (0.5); 2.9179 (0.3); 2.7496 (0.6); 2.5982 (0.5); 2.5348 (24.9); 2.5288 (54.8); 2.5228 (77.0); 2.5168 (56.6); 2.5109 (26.9); 2.4534 (0.6); 2.3817 (95.8); 2.3423 (0.8); 2.3139 (0.7); 2.2941 (0.5); 2.2137 (0.5); 2.1626 (0.5); 2.0976 (0.8); 2.0102 (2.8); 1.9299 (5.1); 1.5677 (3.1); 1.5475 (9.6); 1.5410 (10.8); 1.5219 (4.3); 1.5030 (3.2); 1.4836 (9.7); 1.4759 (10.8); 1.4571 (4.6); 1.3936 (0.6); 1.3114 (0.6); 1.2803 (1.0); 1.2518 (4.8); 1.2297 (11.0); 1.2213 (13.4); 1.2028 (9.2); 1.1987 (13.4); 1.1907 (11.2); 1.1716 (3.7); 1.1432 (0.6); 1.1317 (0.5); 1.1126 (0.4); 1.1006 (0.3); 0.2163 (0.3); 0.0318 (2.0); 0.0209 (77.6); 0.0101 (2.9); -0.0451 (0.5)
1-105:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 7.4345 (1.4); 7.4150 (3.0); 7.3953 (1.8); 7.1961 (2.4); 7.1769 (2.0); 7.1360 (3.7); 7.1257 (2.5); 7.1052 (1.7); 3.0932 (0.7); 3.0678 (1.2); 3.0413 (1.1); 3.0331 (1.0); 3.0096 (0.7); 2.4991 (5.8); 2.3697 (16.0); 2.0205 (1.5); 1.9950 (2.5); 1.9857 (1.2); 1.9739 (2.5); 1.9487 (0.9); 1.9068 (4.6); -0.0002 (2.1)
1-106:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4486 (0.6); 7.4231 (1.3); 7.3976 (0.8); 7.3944 (0.7); 7.2989 (7.9); 7.1642 (3.1); 7.1609 (3.9); 7.1357 (1.3); 7.1290 (1.8); 7.1025 (1.0); 5.4474 (0.4); 5.4265 (1.0); 5.4056 (1.4); 5.3847 (1.0); 5.3639 (0.4); 2.4549 (16.0); 1.5912 (8.8); 1.5701 (1.4); 1.5647 (1.5); 1.5597 (0.8); 1.5449 (0.5); 1.5416 (0.4); 1.5304 (0.4); 1.5271 (0.4); 1.5065 (1.4); 1.5009 (1.5); 1.4959 (0.8); 1.4813 (0.6); 1.4417 (15.8); 1.4208 (15.7); 1.1589 (0.4); 1.1555 (0.5); 1.1408 (0.8); 1.1358 (1.5); 1.1299 (1.7); 1.1062 (1.8); 1.1011 (1.4); 1.0798 (0.4); 1.0765 (0.4); 0.0378 (9.4); 0.0268 (0.4)
1-107:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9179 (6.4); 7.6094 (0.4); 7.2986 (12.0); 7.2758 (0.9); 7.2703 (0.8); 7.2528 (0.8); 7.2468 (0.8); 7.2235 (0.9); 7.1975 (1.4); 7.1945 (1.4); 7.1706 (0.7); 7.1679 (0.8); 7.1405 (0.6); 7.1375 (0.6); 7.1348 (0.6); 7.1165 (0.8); 7.1141 (0.7); 5.4071 (0.4); 5.3862 (1.1); 5.3653 (1.4); 5.3445 (1.1); 5.3236 (0.4); 2.9082 (0.3); 2.8949 (0.6); 2.8677 (0.6); 2.8544 (0.3); 2.8268 (0.3); 1.9830 (0.3); 1.9734 (0.4); 1.9603 (0.6); 1.9564 (0.5); 1.9434 (0.6); 1.9339 (0.7); 1.9207 (0.4); 1.9168 (0.7); 1.8944 (0.4); 1.8772 (0.3); 1.7473 (0.3); 1.7342 (0.4); 1.7204 (0.6); 1.7069 (0.8); 1.6927 (0.6); 1.6785 (0.7); 1.6652 (0.6); 1.6511 (0.4); 1.5844 (7.9); 1.4782 (1.3); 1.4618 (16.0); 1.4409 (15.7); 0.0481 (0.4); 0.0433 (0.4); 0.0374 (14.2); 0.0297 (0.4); 0.0280 (0.4); 0.0265 (0.5)
1-108:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.5552 (3.0); 7.2775 (0.6); 7.2745 (0.6); 7.2662 (1.2); 7.2488 (2.2); 7.2366 (0.8); 7.2264 (1.0); 7.2165 (0.5); 7.2005 (0.4); 3.3478 (16.0); 3.1018 (0.4); 3.0737 (0.4); 2.5340 (2.9); 2.5281 (6.1); 2.5220 (8.3); 2.5160 (6.1); 2.5101 (2.9); 2.0921 (0.6); 2.0769 (0.4); 2.0710 (0.5); 2.0636 (0.4); 2.0544 (0.4); 2.0477 (0.6); 2.0339 (0.4); 2.0199 (0.4); 2.0092 (0.5); 1.6200 (0.5); 0.0312 (0.4); 0.0204 (11.4); 0.0095 (0.5)
1-109:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9172 (0.6); 7.2981 (5.1); 7.2842 (0.6); 7.2625 (1.2); 7.2397 (0.9); 7.2341 (1.0); 7.2004 (1.0); 7.1740 (1.8); 7.1470 (1.0); 7.1173 (1.0); 7.0966 (1.1); 7.0713 (0.4); 5.4608 (0.4); 5.4399 (1.1); 5.4190 (1.4); 5.3981 (1.1); 5.3773 (0.4); 2.9312 (0.4); 2.9033 (0.5); 2.8906 (0.8); 2.8629 (0.9); 2.8501 (0.5); 2.8224 (0.5); 2.4670 (16.0); 2.4551 (1.6); 2.2082 (8.2); 1.9938 (0.3); 1.9766 (0.4); 1.9673 (0.4); 1.9540 (0.7); 1.9371 (0.7); 1.9278 (0.7); 1.9110 (0.8); 1.8974 (0.4); 1.8882 (0.4); 1.8710 (0.4); 1.7393 (0.4); 1.7261 (0.4); 1.7122 (0.6); 1.6988 (0.9); 1.6847 (0.7); 1.6707 (0.9); 1.6571 (0.7); 1.6434 (0.4); 1.6300 (0.3); 1.6007 (4.9); 1.4817 (1.2); 1.4683 (1.5); 1.4570 (14.6); 1.4361 (14.0); 1.2956 (0.5); 0.9183 (0.4); 0.0361 (3.6)
1-110:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2790 (2.3); 7.4340 (0.6); 7.4198 (2.0); 7.4024 (3.7); 7.3950 (2.2); 7.3866 (4.6); 7.3720 (2.9); 7.3623 (3.1); 7.3269 (1.8); 7.3015 (16.0); 7.2845 (9.6); 7.2771 (8.0); 7.2585 (1.1); 3.6128 (0.3); 3.5872 (0.4); 3.3811 (0.8); 3.3129 (0.7); 3.2895 (0.7); 3.1978 (0.4); 3.1540 (1.7); 3.1237 (2.2); 3.1138 (3.0); 3.0836 (3.1); 3.0453 (1.9); 2.9110 (2.3); 2.7518 (2.1); 2.7092 (1.2); 2.5340 (13.1); 2.5280 (28.4); 2.5219 (39.3); 2.5158 (28.3); 2.5100 (13.3); 2.4263 (55.4); 2.4070 (3.8); 2.3600 (0.4); 2.2074 (0.4); 2.1720 (0.7); 2.1441 (1.7); 2.1347 (1.0); 2.1229 (2.1); 2.1062 (4.3); 2.0840 (4.2); 2.0712 (5.1); 2.0587 (2.6); 2.0447 (3.8); 2.0300 (2.4); 2.0159 (0.8); 2.0093 (1.0); 2.0035 (0.5); 1.9289 (1.1); 0.0307 (1.7); 0.0290 (0.9); 0.0275 (1.2); 0.0199 (53.0); 0.0122 (1.8); 0.0107 (1.8); 0.0090 (1.9)
1-111:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 7.9572 (6.3); 7.1617 (0.3); 7.1570 (0.4); 7.1478 (3.0); 7.1410 (1.9); 7.1387 (1.9); 7.1330 (2.8); 6.9088 (0.7); 6.9020 (0.7); 6.8961 (1.2); 6.8896 (1.1); 6.8827 (0.6); 6.8765 (0.5); 2.7404 (0.9); 2.6089 (16.0); 2.5168 (0.3); 2.5134 (0.6); 2.5098 (0.8); 2.5062 (0.6); 2.0661 (0.6); 2.0596 (0.7); 2.0494 (1.2); 2.0424 (0.5); 2.0391 (0.7); 2.0326 (0.6); 1.0221 (0.9); 1.0134 (2.3); 1.0091 (2.4); 1.0053 (1.3); 1.0007 (1.4); 0.9965 (2.2); 0.9922 (2.3); 0.9840 (0.9); 0.7812 (1.0); 0.7729 (2.5); 0.7706 (2.3); 0.7689 (2.6); 0.7627 (2.5); 0.7587 (2.5); 0.7498 (0.8)
1-112:1 H-NMR(300.2 MHz, CDCl3): δ= 7.7840 (4.1); 7.2987 (18.6); 7.1414 (0.4); 7.1348 (0.4); 7.1147 (1.2); 7.1077 (1.1); 7.0988 (2.6); 7.0868 (1.2); 7.0781 (1.7); 7.0501 (0.4); 6.8222 (0.6); 6.8160 (0.6); 6.7994 (0.9); 6.7902 (0.8); 6.7810 (0.5); 6.7691 (0.4); 4.5299 (1.2); 4.5062 (3.6); 4.4824 (3.6); 4.4586 (1.2); 2.7388 (14.0); 2.4130 (0.4); 2.2888 (0.4); 2.1435 (0.4); 2.1330 (0.5); 2.1158 (0.8); 2.0985 (0.4); 2.0878 (0.4); 1.5881 (16.0); 1.4814 (3.8); 1.4577 (7.7); 1.4339 (3.7); 1.2924 (0.4); 1.0457 (0.6); 1.0306 (1.5); 1.0236 (1.7); 1.0091 (0.9); 1.0019 (1.6); 0.9952 (1.5); 0.9809 (0.7); 0.8042 (0.8); 0.7894 (1.8); 0.7831 (1.8); 0.7722 (1.6); 0.7669 (1.8); 0.7503 (0.6); 0.0481 (1.1); 0.0373 (24.0); 0.0263 (1.0)
1-113:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.2836 (1.4); 8.2772 (16.0); 8.0256 (0.8); 7.5855 (0.4); 7.5487 (1.7); 7.5442 (1.5); 7.5229 (3.8); 7.5103 (3.4); 7.5049 (3.4); 7.4983 (2.9); 7.4936 (2.4); 7.4892 (2.2); 7.4835 (2.2); 7.3768 (2.8); 7.3503 (3.9); 7.3238 (1.6); 4.0603 (0.6); 4.0366 (0.6); 3.3605 (1.2); 3.2371 (0.6); 2.5342 (7.1); 2.5283 (15.8); 2.5223 (22.2); 2.5162 (16.4); 2.5104 (7.8); 2.0093 (2.6); 1.9292 (7.7); 1.5028 (1.0); 1.4759 (3.9); 1.4545 (1.6); 1.4402 (1.2); 1.4132 (4.0); 1.3921 (1.8); 1.2548 (0.4); 1.2247 (1.6); 1.2181 (1.1); 1.2027 (4.2); 1.1948 (5.8); 1.1732 (5.1); 1.1443 (1.2); 0.0302 (0.7); 0.0194 (25.5); 0.0085 (1.1)
1-114:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9261 (0.4); 7.9166 (5.3); 7.6145 (0.4); 7.4855 (0.3); 7.4803 (0.5); 7.4756 (0.4); 7.4594 (0.9); 7.4543 (1.0); 7.4502 (0.6); 7.4386 (0.5); 7.4333 (0.6); 7.4286 (0.5); 7.3637 (0.4); 7.3600 (0.4); 7.3388 (1.0); 7.3366 (0.9); 7.3154 (0.8); 7.3128 (0.7); 7.3095 (0.7); 7.2990 (4.7); 7.2686 (1.1); 7.2422 (1.3); 7.2156 (0.5); 7.0516 (1.2); 7.0471 (0.8); 7.0317 (0.7); 7.0277 (0.4); 5.4051 (0.4); 5.3843 (1.0); 5.3634 (1.4); 5.3425 (1.0); 5.3217 (0.4); 5.2848 (0.6); 5.2686 (0.6); 1.6046 (3.3); 1.5156 (0.5); 1.4927 (1.6); 1.4894 (1.6); 1.4769 (1.7); 1.4597 (16.0); 1.4388 (15.7); 1.4037 (0.7); 1.3039 (1.0); 1.2341 (0.6); 1.2131 (1.4); 1.2057 (1.6); 1.1833 (1.7); 1.1758 (1.3); 1.1636 (0.5); 1.1557 (0.8); 1.1340 (0.5); 1.1287 (0.4); 0.9410 (0.3); 0.9194 (1.1); 0.8961 (0.4); 0.0375 (6.0)
1-115:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4720 (0.4); 7.4670 (0.6); 7.4621 (0.4); 7.4457 (0.9); 7.4409 (1.0); 7.4252 (0.5); 7.4199 (0.6); 7.4152 (0.5); 7.3599 (0.3); 7.3545 (0.4); 7.3508 (0.4); 7.3296 (0.9); 7.3275 (0.9); 7.2991 (13.2); 7.2490 (0.9); 7.2224 (1.2); 7.1957 (0.5); 7.0557 (1.4); 7.0506 (1.0); 7.0353 (0.7); 7.0309 (0.4); 5.4608 (0.4); 5.4399 (1.0); 5.4191 (1.3); 5.3982 (1.0); 5.3773 (0.4); 5.2403 (0.8); 5.2239 (0.8); 2.4655 (15.5); 2.4545 (1.8); 1.5914 (11.8); 1.5121 (0.4); 1.4898 (1.6); 1.4817 (2.4); 1.4570 (16.0); 1.4361 (15.8); 1.4231 (1.7); 1.4001 (0.6); 1.3042 (1.3); 1.2301 (0.6); 1.2093 (1.4); 1.2019 (1.6); 1.1796 (1.6); 1.1717 (1.4); 1.1587 (0.6); 1.1516 (0.5); 1.1363 (0.6); 0.9417 (0.5); 0.9200 (1.4); 0.8966 (0.6); 0.0489 (0.5); 0.0380 (16.4); 0.0270 (0.6)
1-116:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 7.2375 (1.0); 7.2279 (2.3); 7.2176 (2.2); 7.2080 (0.8); 7.1225 (1.6); 7.1069 (4.1); 7.0911 (4.0); 7.0819 (2.2); 7.0781 (2.4); 7.0644 (2.5); 7.0514 (1.1); 7.0481 (0.9); 6.8826 (1.6); 6.8789 (1.7); 6.8678 (2.6); 6.8537 (1.4); 6.8508 (1.2); 3.3246 (4.9); 2.9361 (16.0); 2.9258 (15.5); 2.5107 (4.0); 2.5072 (7.6); 2.5036 (10.0); 2.5000 (7.1); 2.4965 (3.3); 2.0717 (0.7); 2.0613 (1.3); 2.0547 (1.4); 2.0445 (2.4); 2.0343 (1.4); 2.0277 (1.2); 2.0173 (0.6); 1.9905 (0.7); 1.1768 (0.4); 1.0204 (2.0); 1.0117 (4.9); 1.0074 (5.0); 1.0037 (2.7); 0.9991 (2.7); 0.9948 (4.7); 0.9905 (4.7); 0.9823 (1.8); 0.7894 (0.4); 0.7702 (2.3); 0.7618 (5.3); 0.7597 (4.7); 0.7578 (5.5); 0.7516 (5.0); 0.7475 (5.2); 0.7386 (1.6)
1-117:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 7.7080 (0.7); 7.6925 (1.4); 7.6727 (5.0); 7.6569 (9.6); 7.6416 (5.4); 7.6129 (5.4); 7.5990 (9.9); 7.5860 (6.4); 7.4613 (8.0); 7.4453 (12.7); 7.4293 (5.6); 7.3884 (1.4); 7.3802 (7.3); 7.2804 (2.9); 7.2721 (16.0); 7.1723 (1.4); 7.1640 (7.9); 4.0581 (0.6); 3.0700 (2.2); 2.5471 (0.5); 2.5071 (3.5); 2.5039 (4.7); 2.5006 (3.7); 2.4512 (0.4); 2.4180 (100.6); 2.4073 (17.9); 2.3005 (0.6); 2.2854 (0.6); 1.1096 (0.4); 1.0962 (6.9)
1-118:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9331 (5.2); 7.6246 (0.4); 7.3831 (0.6); 7.3773 (0.6); 7.3617 (0.7); 7.3559 (1.3); 7.3506 (0.9); 7.3353 (0.7); 7.3292 (0.8); 7.2990 (0.6); 7.2884 (0.5); 7.2827 (0.5); 7.2666 (0.5); 7.2607 (1.4); 7.2552 (0.9); 7.2392 (1.0); 7.2330 (0.9); 7.1987 (1.2); 7.1940 (1.2); 7.1718 (1.3); 7.1668 (1.4); 7.1448 (0.5); 7.1395 (0.5); 5.3953 (0.4); 5.3744 (1.0); 5.3536 (1.4); 5.3327 (1.0); 5.3119 (0.4); 2.0723 (0.5); 1.4704 (1.4); 1.4512 (16.0); 1.4303 (15.1); 0.0315 (0.8)
1-119:1 H-NMR(499.9 MHz, CDCl3): δ= 7.9360 (16.0); 7.6226 (1.0); 7.3432 (2.2); 7.3407 (2.7); 7.3275 (4.4); 7.3144 (2.4); 7.3116 (2.7); 7.2617 (6.0); 7.2399 (2.1); 7.2374 (2.3); 7.2238 (4.5); 7.2103 (2.9); 7.2076 (2.9); 7.1903 (0.4); 7.1874 (0.4); 7.1586 (3.4); 7.1559 (3.5); 7.1423 (4.6); 7.1395 (4.8); 7.1259 (1.8); 7.1231 (1.9); 6.9462 (0.6); 6.9315 (1.3); 6.9279 (0.9); 6.9210 (0.4); 6.9170 (0.7); 6.9120 (0.6); 6.9051 (0.4); 6.8971 (0.6); 6.8926 (0.4); 5.4641 (1.1); 5.4561 (1.1); 4.5100 (0.9); 4.5010 (4.3); 4.4868 (11.6); 4.4725 (11.4); 4.4582 (3.8); 1.5785 (9.1); 1.4637 (1.5); 1.4455 (12.7); 1.4312 (23.5); 1.4169 (11.4); -0.0002 (6.6)
1-120:1 H-NMR(499.9 MHz, CDCl3): δ= 7.7348 (5.0); 7.3033 (0.7); 7.3005 (0.8); 7.2873 (1.5); 7.2843 (1.2); 7.2743 (0.9); 7.2714 (1.0); 7.2638 (2.0); 7.2379 (0.7); 7.2350 (0.8); 7.2214 (1.6); 7.2189 (1.2); 7.2080 (0.9); 7.2051 (1.0); 7.1317 (1.0); 7.1286 (1.1); 7.1153 (1.5); 7.1122 (1.7); 7.0989 (0.6); 7.0958 (0.7); 5.3387 (0.4); 5.3263 (1.1); 5.3137 (1.5); 5.3012 (1.2); 5.2887 (0.5); 2.7076 (15.4); 1.6075 (3.7); 1.4053 (16.0); 1.3927 (16.0); -0.0002 (1.9)
1-121:1 H-NMR(499.9 MHz, d6 -DMSO): δ= 7.6005 (1.3); 7.5979 (1.5); 7.5844 (2.8); 7.5709 (1.6); 7.5683 (1.6); 7.4782 (1.2); 7.4756 (1.4); 7.4615 (2.9); 7.4475 (1.8); 7.4449 (1.7); 7.3612 (1.9); 7.3584 (2.0); 7.3446 (3.0); 7.3419 (3.2); 7.3281 (1.3); 7.3254 (1.4); 4.4982 (2.4); 4.4840 (7.6); 4.4698 (7.7); 4.4556 (2.5); 3.3159 (12.1); 2.5070 (4.8); 2.5036 (6.5); 2.5004 (5.1); 2.4165 (28.2); 1.3460 (7.8); 1.3318 (16.0); 1.3177 (7.7); -0.0002 (2.0)
1-122:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 7.6263 (7.0); 7.6208 (8.0); 7.6041 (7.8); 7.5988 (15.4); 7.5937 (10.2); 7.5773 (9.0); 7.5715 (9.1); 7.4939 (6.3); 7.4883 (6.7); 7.4705 (6.9); 7.4659 (15.0); 7.4608 (10.0); 7.4430 (11.6); 7.4373 (9.5); 7.3878 (12.6); 7.3827 (12.0); 7.3606 (15.5); 7.3553 (16.0); 7.3332 (6.0); 7.3278 (6.2); 4.2841 (0.3); 4.2288 (0.3); 4.1828 (0.3); 4.0782 (0.4); 4.0617 (0.7); 4.0385 (0.8); 4.0004 (0.5); 3.9889 (0.5); 3.8676 (0.7); 3.8480 (0.7); 3.7660 (1.0); 3.6961 (1.1); 3.6479 (1.4); 3.4652 (2.5); 3.4056 (2.7); 2.8887 (0.6); 2.8098 (0.5); 2.7496 (0.7); 2.7372 (0.6); 2.6482 (1.0); 2.5887 (0.8); 2.5352 (22.4); 2.5292 (46.8); 2.5231 (64.1); 2.5170 (45.9); 2.5109 (21.2); 2.4323 (155.0); 2.3656 (0.8); 2.2932 (0.4); 2.2126 (0.9); 2.0098 (2.0); 1.9302 (3.7); 1.2192 (0.6); 1.1957 (1.1); 1.1719 (0.5); 0.0312 (1.5); 0.0204 (41.7); 0.0095 (1.4)
1-123:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.0097 (16.0); 7.9655 (0.4); 7.5896 (2.0); 7.5839 (2.2); 7.5674 (2.2); 7.5622 (4.0); 7.5570 (2.9); 7.5410 (2.5); 7.5349 (2.6); 7.4546 (1.7); 7.4489 (1.8); 7.4316 (1.8); 7.4268 (4.3); 7.4214 (2.9); 7.4042 (3.6); 7.3981 (2.8); 7.3687 (3.9); 7.3642 (3.6); 7.3419 (4.2); 7.3370 (4.5); 7.3147 (1.6); 7.3096 (1.7); 3.3531 (2.9); 2.6342 (42.4); 2.5345 (5.6); 2.5285 (12.2); 2.5224 (16.9); 2.5163 (12.2); 2.5103 (5.7); 2.2979 (0.5); 2.2918 (0.5); 2.0090 (1.3); 1.2179 (0.4); 1.1942 (0.7); 1.1704 (0.3); 0.0191 (8.3)
1-124:1 H-NMR(300.1 MHz, d6 -DMSO): δ= 8.3018 (6.7); 7.6593 (0.5); 7.6329 (1.5); 7.6066 (1.2); 7.5224 (1.4); 7.4929 (2.4); 7.4756 (1.3); 7.4722 (1.3); 7.4453 (0.9); 7.4418 (0.8); 7.2608 (1.1); 7.0752 (2.3); 6.8897 (1.1); 3.9259 (16.0); 3.3292 (2.6); 2.5084 (2.8); 2.5026 (3.7); 2.4968 (2.6); -0.0005 (2.7)
1-125:1 H-NMR(400.2 MHz, d6 -DMSO): δ= 14.0741 (0.4); 7.9771 (5.9); 7.7099 (0.6); 7.6902 (1.7); 7.6704 (1.4); 7.6376 (1.7); 7.6175 (1.0); 7.5995 (2.1); 7.5297 (1.2); 7.5091 (0.9); 3.3301 (0.6); 2.6225 (16.0); 2.5099 (6.7); 2.5056 (14.0); 2.5011 (19.1); 2.4966 (13.7); 2.4923 (6.5); 0.0071 (0.6); -0.0011 (17.7); -0.0094 (0.7)
1-126:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.0394 (5.5); 7.7256 (0.6); 7.7063 (1.9); 7.6866 (1.6); 7.6542 (2.3); 7.6331 (3.8); 7.5609 (1.6); 7.5403 (1.4); 3.9145 (16.0); 3.3269 (11.0); 2.6442 (15.2); 2.5097 (1.8)
1-127:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 8.3829 (16.0); 7.7559 (0.9); 7.7302 (3.0); 7.7046 (6.9); 7.6890 (4.6); 7.6636 (1.2); 7.6081 (2.8); 7.6012 (1.6); 7.5825 (1.5); 3.6424 (0.4); 3.6205 (0.5); 3.5991 (0.5); 3.3722 (3.1); 2.5345 (3.4); 2.5285 (7.2); 2.5224 (9.8); 2.5164 (7.0); 2.5104 (3.2); 2.0087 (0.7); 1.9291 (0.4); 1.3749 (1.9); 1.1939 (0.4); 0.0188 (7.1)
1-128:1 H-NMR(300.2 MHz, CDCl3): δ= 7.5864 (0.9); 7.5640 (3.0); 7.5176 (1.3); 7.4753 (0.6); 7.4662 (1.0); 7.4588 (0.6); 7.4542 (0.3); 7.4510 (0.3); 7.4447 (0.6); 7.4366 (0.3); 7.2983 (7.8); 4.0660 (0.4); 4.0444 (15.4); 3.6947 (1.7); 3.6726 (4.0); 3.6510 (2.0); 3.3667 (16.0); 3.1857 (1.9); 3.1640 (3.7); 3.1420 (1.6); 1.5842 (6.0); 0.0375 (8.1)
1-129:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.2191 (15.2); 9.2072 (15.9); 8.0823 (15.8); 8.0704 (15.6); 7.7415 (2.8); 7.7211 (8.1); 7.7111 (2.0); 7.7009 (7.4); 7.6691 (16.0); 7.6633 (13.8); 7.5863 (6.9); 7.5666 (5.4); 3.5012 (0.4); 3.3202 (3.0); 3.1349 (0.4); 2.5131 (12.7); 2.5088 (16.3); 2.5046 (12.1); 1.9947 (0.8); 1.1820 (0.4)
1-130:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9303 (10.8); 7.4583 (0.9); 7.4525 (1.9); 7.4489 (1.8); 7.4421 (2.6); 7.4358 (4.6); 7.4289 (5.6); 7.3628 (2.7); 7.3513 (0.3); 7.3462 (0.3); 7.3356 (4.3); 7.3276 (0.6); 7.3158 (0.6); 7.3075 (2.3); 7.2983 (4.5); 7.2274 (2.0); 7.2237 (2.2); 7.2199 (2.1); 7.2163 (1.8); 7.2002 (1.3); 7.1960 (1.5); 7.1933 (1.4); 7.1892 (1.1); 4.5332 (2.4); 4.5094 (7.5); 4.4856 (7.6); 4.4618 (2.5); 1.6025 (5.0); 1.4783 (7.9); 1.4546 (16.0); 1.4307 (7.6); 0.0365 (4.5)
表5：根據式(2)之化合物
Figure 02_image083
Ex N° R1
Figure 02_image085
 LogP
2-01 H 2-(4-乙炔基-2-甲苯基)-2,2-二氟乙基 0.93[a]
2-02 H 2-(4-環丙基-2-甲苯基)-2,2-二氟乙基 1.30[a]
2-03 H 2,2-二氟-2-(2-氟-4,6-二甲苯基)乙基 0.95[a]
2-04 H 2-(3-溴-2-氯苯基)-2,2-二氟乙基 0.87[a]
2-05 H rac-2-氟-2-(4-碘基苯基)乙基 0.73[a]
2-06 H rac- 2-[4-(二氟乙基)-2-甲苯基]-2-氟乙基 0.69[a]
2-07 H rac-2-(2-氯-4-環丙基苯基)-2-氟乙基 1.15[a]
表6：
2-01:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8030 (0.4); 7.7768 (0.5); 7.7464 (3.9); 7.7421 (5.2); 7.7370 (2.7); 7.7264 (2.0); 7.7195 (6.8); 7.7142 (6.0); 7.7065 (4.0); 7.7022 (5.3); 7.6971 (2.7); 7.6865 (2.2); 7.6795 (6.7); 7.6744 (5.6); 7.6440 (0.7); 7.6163 (1.6); 7.6112 (1.8); 7.6064 (1.1); 7.6012 (1.2); 7.5922 (3.8); 7.5867 (3.8); 7.5783 (1.6); 7.5725 (2.4); 7.5674 (4.6); 7.5622 (4.1); 7.5570 (1.9); 7.5307 (5.6); 7.5262 (4.0); 7.5210 (5.6); 7.5166 (3.0); 7.5109 (4.5); 7.5058 (6.5); 7.5009 (5.6); 7.4961 (6.3); 7.4906 (2.4); 7.4828 (3.1); 7.4779 (2.8); 7.4729 (3.4); 7.4676 (4.1); 7.4517 (1.7); 7.4385 (8.2); 7.4101 (5.7); 7.3977 (6.4); 7.3340 (1.0); 7.2984 (53.6); 6.9475 (0.5); 5.3375 (1.3); 4.1947 (0.5); 4.1709 (1.5); 4.1471 (1.5); 4.1234 (0.6); 4.1024 (0.4); 3.2771 (5.8); 3.2275 (11.6); 3.2148 (1.2); 3.1780 (6.0); 3.1637 (1.0); 3.1478 (11.9); 2.5255 (0.6); 2.4672 (9.4); 2.4593 (16.0); 2.4514 (9.1); 2.3287 (0.4); 2.2570 (0.4); 2.2439 (0.4); 2.0835 (8.2); 2.0459 (0.4); 2.0360 (0.4); 2.0194 (0.3); 1.6972 (0.3); 1.6708 (0.5); 1.6487 (0.6); 1.6194 (0.7); 1.4966 (2.3); 1.3809 (0.9); 1.3500 (1.0); 1.3206 (2.8); 1.2968 (5.1); 1.2730 (2.2); 1.0369 (0.4); 0.9977 (0.4); 0.9723 (0.7); 0.9482 (0.4); 0.9361 (0.5); 0.9175 (0.5); 0.8925 (0.3); 0.3172 (0.6); 0.3008 (0.6); 0.2947 (0.5); 0.2843 (5.5); 0.2768 (3.1); 0.2705 (7.3); 0.2562 (1.6); 0.2532 (1.6); 0.2469 (4.0); 0.2365 (1.5); 0.2088 (1.3); 0.2037 (1.4); 0.1967 (3.8); 0.1890 (2.3); 0.1602 (1.0); 0.1550 (1.0); 0.1494 (2.4); 0.1441 (3.8); 0.1203 (1.3); 0.1063 (3.2); 0.0880 (0.5); 0.0728 (0.6); 0.0618 (0.4); 0.0474 (2.0); 0.0366 (54.6); 0.0257 (2.6); 0.0155 (1.0); -0.0026 (0.4); -0.0165 (0.7); -0.1616 (0.7)
2-02:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 7.5958 (0.3); 7.5766 (0.6); 7.5553 (0.4); 7.2981 (4.4); 7.2781 (5.2); 7.2108 (0.4); 7.1933 (0.4); 7.1631 (0.3); 7.1093 (0.4); 7.0992 (0.4); 7.0394 (0.7); 6.9771 (7.1); 6.9486 (4.1); 6.9071 (1.2); 6.8860 (0.7); 6.7878 (0.8); 6.7697 (0.6); 6.5393 (2.5); 6.4871 (0.8); 6.3004 (2.7); 3.3329 (60.7); 3.2642 (0.6); 3.2415 (0.4); 3.2363 (0.4); 3.2181 (0.4); 3.1900 (0.4); 3.1606 (3.5); 3.1221 (7.1); 3.0833 (3.9); 3.0519 (0.9); 2.9975 (0.6); 2.9711 (7.2); 2.9126 (0.6); 2.7148 (0.4); 2.5111 (35.1); 2.5070 (29.0); 2.3879 (1.7); 2.3544 (16.0); 2.2861 (1.3); 2.2478 (1.9); 2.2119 (0.7); 2.1730 (0.8); 2.1543 (0.7); 2.1033 (0.4); 1.9384 (1.3); 1.9258 (2.3); 1.9175 (2.9); 1.9051 (4.3); 1.8929 (3.6); 1.8844 (3.5); 1.8716 (2.6); 1.8272 (1.1); 1.3889 (0.5); 1.3674 (0.3); 1.3507 (0.6); 1.1684 (8.5); 1.1354 (8.8); 0.9882 (2.6); 0.9771 (6.3); 0.9717 (7.2); 0.9615 (5.4); 0.9564 (7.6); 0.9509 (7.7); 0.9410 (4.5); 0.7405 (0.4); 0.7160 (2.5); 0.7053 (6.6); 0.7007 (7.2); 0.6932 (7.4); 0.6882 (8.3); 0.6772 (4.8); 0.3232 (0.4)
2-03:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 6.9629 (1.9); 6.9337 (5.8); 3.3337 (6.4); 3.1780 (2.3); 3.1398 (4.7); 3.1015 (2.5); 2.5152 (3.4); 2.5111 (4.7); 2.5070 (3.7); 2.4123 (4.6); 2.4016 (9.5); 2.3907 (5.4); 2.2867 (16.0); 1.6930 (4.1)
2-04:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 7.9521 (10.7); 7.9324 (11.5); 7.7005 (0.4); 7.6529 (10.3); 7.6502 (10.7); 7.6332 (12.7); 7.6305 (12.6); 7.4291 (9.2); 7.4092 (16.0); 7.3894 (7.6); 7.2119 (0.4); 3.3535 (15.6); 3.3158 (31.4); 3.2780 (16.0); 3.1623 (0.4); 3.1315 (0.4); 2.5152 (2.9); 2.5112 (3.9); 2.5071 (3.1); 1.6878 (10.2); 1.3625 (0.4)
2-05:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 8.3740 (0.4); 8.3578 (0.4); 8.3255 (1.6); 8.2699 (6.4); 8.1811 (0.3); 7.9546 (0.4); 7.8911 (1.0); 7.8596 (15.1); 7.8396 (16.0); 7.7850 (0.3); 7.7775 (0.4); 7.7687 (0.4); 7.7138 (6.1); 7.6931 (6.5); 7.3163 (0.5); 7.2824 (13.4); 7.2625 (12.3); 7.1511 (0.4); 7.1091 (5.9); 7.0885 (5.4); 5.8556 (2.1); 5.8454 (2.4); 5.8359 (2.0); 5.8256 (2.0); 5.7335 (2.0); 5.7264 (2.3); 5.7103 (2.2); 5.7041 (2.1); 3.8271 (1.2); 3.5626 (0.4); 3.5394 (0.4); 3.4503 (0.6); 3.3398 (1168.7); 3.3377 (1019.1); 3.2838 (3.0); 3.2493 (1.2); 3.0294 (1.6); 3.0023 (1.9); 2.8456 (3.0); 2.8245 (3.4); 2.8067 (2.0); 2.7189 (0.6); 2.6835 (3.2); 2.6790 (4.5); 2.6745 (3.4); 2.6500 (1.6); 2.5491 (163.8); 2.5323 (9.4); 2.5274 (14.4); 2.5188 (278.8); 2.5144 (597.6); 2.5099 (808.1); 2.5054 (583.3); 2.5010 (282.0); 2.3756 (0.9); 2.3411 (3.4); 2.3367 (4.7); 2.3320 (3.5); 2.3274 (1.8); 2.3072 (0.4); 2.0818 (0.4); 2.0548 (0.3); 0.0075 (1.6)
2-06:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.7157 (5.6); 7.5744 (8.5); 7.5544 (14.3); 7.5024 (11.2); 7.4819 (7.3); 7.4619 (16.0); 7.1776 (6.1); 7.0381 (13.0); 6.8987 (6.4); 6.2790 (3.0); 6.2725 (3.4); 6.2572 (3.1); 6.2513 (3.1); 6.1552 (3.8); 6.1330 (3.8); 3.3496 (2.4); 3.3267 (1.4); 3.3133 (5.4); 3.2913 (10.4); 3.2842 (8.4); 3.2736 (4.7); 3.2492 (4.6); 3.2000 (5.0); 3.1964 (4.9); 3.1650 (2.6); 2.5650 (0.4); 2.5096 (4.7); 2.4076 (64.5); 2.2464 (0.4); 1.9880 (0.6); 1.1742 (0.3)
2-07:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 8.6578 (14.7); 7.4994 (0.5); 7.4747 (10.8); 7.4544 (12.1); 7.2592 (16.0); 7.1740 (8.8); 7.1539 (7.7); 6.2003 (3.4); 6.1803 (3.3); 6.0806 (3.4); 6.0599 (3.4); 3.4325 (1.7); 3.3987 (5.2); 3.3735 (3.7); 3.3372 (1.9); 3.2913 (2.9); 3.2565 (1.8); 3.2017 (2.7); 3.1666 (1.9); 2.9854 (0.7); 2.5097 (7.6); 2.0180 (1.5); 2.0054 (3.2); 1.9967 (3.9); 1.9848 (6.1); 1.9728 (4.0); 1.9641 (3.4); 1.9514 (1.8); 1.2461 (0.5); 1.0946 (0.4); 1.0683 (0.3); 1.0499 (0.7); 1.0313 (3.8); 1.0200 (11.0); 1.0149 (12.0); 0.9993 (11.3); 0.9945 (10.9); 0.9840 (4.3); 0.9670 (0.9); 0.9461 (0.7); 0.8630 (0.6); 0.8044 (0.6); 0.7912 (0.7); 0.7661 (4.7); 0.7550 (13.9); 0.7430 (12.7); 0.7390 (13.2); 0.7272 (3.6); 0.7031 (0.6); 0.6918 (0.7); 0.6806 (0.5)
表7：根據式(3)之化合物
Figure 02_image087
Ex N° R1 R7 R8 G
Figure 02_image089
 LogP
3-01 H Cl H Cl 2-(2,4-二甲基苯基)乙基 3.02[a]
3-02 H Cl H Cl rac-2-(2,4-二氯苯基)-2-氟乙基 3.02[a]
3-03 H Cl H Cl 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.19[a]
3-04 H 甲基 H Cl 2-(4-溴-2-氯苯基)-2,2-二氟乙基 2.76[a]
3-05 H Cl H Cl 2-(4-氯苯基)-2,2-二氟乙基 2.98[a]
3-06 H 甲基 H Cl 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.20[a]
3-07 H Cl H Cl 2-(2,4-二氯苯基)乙基 3.15[a]
3-08 H Cl H Cl rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.27[a]
3-09 H Cl H Cl 2-(2,4-二氯苯基)-2,2-二氟乙基 3.27[a]
3-10 H Cl H Cl 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.29[a] ;3.24[b]
3-11 H Cl H Cl 2-(4-溴-2-甲基苯基)-2,2-二氟乙基 3.39[a]
3-12 H Cl H Cl rac-7-溴-1,2,3,4-四氫萘-1-基 3.29[a]
3-13 H Cl H Cl rac-6-溴-1,2,3,4-四氫萘-1-基 3.37[a]
3-14 H Cl H Cl rac-5-溴二氫茚-1-基 3.11[a]
3-15 H Cl H Cl rac-2-甲基-4,5,6,7-四氫-1-苯并噻吩-7-基 2.98[a]
3-16 H Cl H Cl rac-4,5,6,7-四氫-1-苯并噻吩-7-基 2.60[a]
3-17 H Cl H Cl rac-2-氯-4,5,6,7-四氫-1-苯并噻吩-7-基 3.21[a]
3-18 H Cl H Cl rac-1-(1-甲基-1H-吲哚-3-基)乙基 2.71[a]
3-19 H Cl 甲基 Cl 2-(2,4-二甲基苯基)-2,2-二氟乙基 3.31[a]
3-20 H Cl 甲基 Cl rac-2-(2,4-二氯苯基)-2-氟乙基 3.34[a]
3-21 H Cl 甲基 Cl rac-2-(4-溴-2-氯苯基)-2-氟乙基 3.43[a]
3-22 H Cl 甲基 Cl rac-2-(2,4-二甲基苯基)-2-氟乙基 3.19[a]
3-23 H Cl 甲基 Cl rac-2-(2-氯-4-甲基苯基)-2-氟乙基 3.22[a]
3-24 H Cl 甲基 Cl rac-2-(2-氯-4-環丙基苯基)-2-氟乙基 3.56[a]
3-25 H Cl 甲基 Cl 2-(4-環丙基-2-甲基苯基)-2,2-二氟乙基 3.69[a]
3-26 H Cl 甲基 Cl 2-(4-溴-2-氯苯基)-2,2-二氟乙基 3.56[a]
3-27 H Cl 甲基 Cl 2-(2-氯-4-甲基苯基)-2,2-二氟乙基 3.31[a]
3-28 H Cl 甲基 Cl 2-(4-溴-2-甲基苯基)-2,2-二氟乙基 3.60[a]
表8：
3-01:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8392 (8.7); 7.2985 (18.2); 7.0958 (1.6); 7.0704 (3.5); 7.0566 (2.8); 7.0297 (2.0); 7.0038 (0.9); 6.5514 (0.6); 3.7935 (1.5); 3.7700 (3.5); 3.7504 (3.5); 3.7270 (1.7); 3.0051 (2.5); 2.9816 (4.7); 2.9581 (2.2); 2.3972 (0.4); 2.3675 (16.0); 2.3391 (14.3); 2.0969 (0.3); 1.5817 (9.8); 0.0494 (0.8); 0.0384 (24.0); 0.0275 (0.9)
3-02:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 14.0362 (0.6); 9.7192 (0.4); 9.2918 (1.2); 9.2719 (2.4); 9.2521 (1.2); 8.1784 (16.0); 8.0140 (2.6); 7.7484 (3.4); 7.7441 (4.2); 7.7392 (3.4); 7.7259 (0.9); 7.6417 (2.9); 7.6271 (0.7); 7.6138 (7.6); 7.5868 (4.8); 7.5802 (4.3); 7.5679 (1.7); 7.5587 (2.7); 7.5523 (2.5); 6.0846 (1.0); 6.0707 (1.2); 6.0639 (1.4); 6.0503 (1.0); 5.9294 (1.0); 5.9110 (1.6); 5.8959 (1.0); 5.7767 (0.5); 3.9096 (0.4); 3.8943 (1.2); 3.8818 (1.7); 3.8643 (2.4); 3.8439 (1.2); 3.8091 (1.8); 3.7884 (2.4); 3.7760 (1.2); 3.7676 (1.1); 3.3876 (4.3); 3.2189 (11.8); 3.0969 (1.8); 2.6491 (17.7); 2.5341 (6.9); 2.5282 (14.5); 2.5221 (19.8); 2.5160 (14.4); 2.5101 (6.8); 1.1264 (4.7); 0.0311 (0.8); 0.0202 (23.4); 0.0093 (0.9)
3-03:1 H-NMR(400.1 MHz, d6 -DMSO): δ= 9.3646 (1.1); 9.3493 (2.3); 9.3339 (1.2); 8.0687 (11.4); 7.3925 (3.3); 7.3729 (3.9); 7.1436 (4.8); 7.1160 (2.2); 4.1022 (1.3); 4.0866 (1.3); 4.0640 (2.8); 4.0485 (2.8); 4.0259 (1.5); 4.0103 (1.4); 3.3336 (11.5); 2.5137 (4.4); 2.5095 (5.9); 2.5053 (4.5); 2.4411 (11.5); 2.3120 (16.0); 2.0831 (2.3)
3-04:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.3209 (1.6); 9.3010 (3.3); 9.2809 (1.6); 7.9515 (5.8); 7.9458 (6.2); 7.7622 (3.0); 7.7561 (2.8); 7.7341 (4.4); 7.7280 (4.4); 7.6322 (16.0); 7.6252 (9.4); 7.5966 (5.6); 4.2852 (1.8); 4.2649 (1.8); 4.2381 (3.8); 4.2176 (3.7); 4.1907 (2.0); 4.1702 (1.8); 3.3484 (16.0); 2.6602 (42.2); 2.5337 (2.1); 2.5279 (4.4); 2.5219 (5.9); 2.5159 (4.4); 2.5102 (2.1); 0.0180 (5.3)
3-05:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.3415 (1.2); 9.3208 (2.5); 9.3004 (1.3); 8.2438 (0.5); 8.1509 (16.0); 8.1388 (0.4); 8.1319 (0.4); 7.6786 (2.5); 7.6704 (1.3); 7.6486 (13.5); 7.6346 (13.0); 7.6140 (1.8); 7.6046 (3.0); 7.5778 (0.4); 7.5674 (0.4); 4.1703 (1.6); 4.1494 (1.6); 4.1223 (3.5); 4.1014 (3.4); 4.0742 (1.8); 4.0534 (1.7); 4.0403 (0.3); 3.3482 (18.7); 3.0439 (0.4); 2.8843 (0.5); 2.5370 (2.5); 2.5311 (5.2); 2.5250 (7.1); 2.5190 (5.1); 2.5131 (2.5); 2.0120 (0.5); 0.0328 (0.5); 0.0220 (12.0); 0.0111 (0.4)
3-06:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6453 (4.7); 7.4228 (1.4); 7.3969 (1.7); 7.2975 (6.1); 7.1085 (3.0); 7.0797 (1.0); 7.0306 (0.6); 5.3357 (0.8); 4.2579 (1.0); 4.2376 (1.0); 4.2087 (2.1); 4.1884 (2.0); 4.1594 (1.1); 4.1391 (1.1); 2.7841 (16.0); 2.7727 (0.9); 2.5340 (3.0); 2.5269 (5.6); 2.5195 (3.1); 2.3770 (7.6); 2.3307 (0.4); 2.0425 (0.5); 1.6317 (1.7); 0.0352 (5.8)
3-07:1 H-NMR(300.2 MHz, CDCl3): δ= 8.2560 (2.6); 7.9964 (3.1); 7.8594 (16.0); 7.6443 (0.4); 7.5511 (0.8); 7.5371 (0.6); 7.4529 (5.2); 7.4326 (4.4); 7.4261 (4.6); 7.3250 (0.4); 7.2984 (57.6); 7.2891 (1.5); 7.2665 (8.8); 7.2612 (15.2); 7.2536 (2.4); 7.2465 (1.7); 7.2333 (3.0); 7.2289 (4.0); 7.2261 (4.2); 7.2191 (3.7); 7.1888 (5.0); 7.1615 (2.0); 6.6000 (0.9); 3.8494 (2.7); 3.8263 (6.4); 3.8061 (6.5); 3.7831 (3.2); 3.7566 (1.1); 3.7364 (1.0); 3.7125 (0.5); 3.6463 (1.6); 3.6235 (4.0); 3.6013 (3.8); 3.5779 (1.8); 3.1517 (5.2); 3.1286 (10.1); 3.1054 (4.7); 3.0965 (1.3); 3.0726 (1.6); 3.0490 (0.9); 3.0318 (3.2); 3.0082 (5.4); 2.9847 (2.6); 2.0846 (1.5); 1.3216 (0.4); 1.2976 (1.2); 1.2923 (1.1); 1.2741 (0.4); 0.0481 (2.3); 0.0374 (65.9); 0.0264 (2.6)
3-08:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 9.2939 (1.6); 9.2748 (3.0); 9.2561 (1.5); 8.1801 (13.0); 7.8553 (5.3); 7.7168 (2.8); 7.7108 (2.5); 7.6891 (3.9); 7.6829 (3.6); 7.5608 (6.2); 7.5329 (4.5); 6.0683 (1.0); 6.0552 (1.4); 6.0482 (1.5); 6.0348 (1.1); 5.9136 (1.0); 5.8954 (1.7); 5.8808 (1.1); 3.8903 (1.2); 3.8784 (1.9); 3.8600 (2.6); 3.8401 (1.2); 3.8045 (2.0); 3.7841 (2.7); 3.7634 (1.2); 3.3473 (16.0); 3.2176 (0.8); 2.6477 (1.2); 2.5274 (8.7); 2.5216 (11.1); 2.5159 (8.3); 0.0188 (6.4)
3-09:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8349 (16.0); 7.8241 (0.4); 7.6371 (4.8); 7.6087 (6.0); 7.5614 (4.1); 7.5580 (4.1); 7.5550 (4.3); 7.5164 (0.4); 7.4140 (3.2); 7.4073 (3.0); 7.3858 (2.5); 7.3790 (2.3); 7.2986 (19.4); 6.9588 (1.4); 6.9477 (1.0); 5.3378 (0.8); 4.4506 (2.8); 4.4297 (2.8); 4.4020 (6.0); 4.3811 (5.7); 4.3534 (3.0); 4.3325 (2.9); 1.5991 (7.5); 1.2912 (0.4); 0.1061 (0.8); 0.0471 (0.9); 0.0363 (19.1); 0.0254 (0.8)
3-10:1 H-NMR(400.0 MHz, d6 -DMSO): δ= 9.3457 (1.7); 9.3301 (3.4); 9.3146 (1.7); 8.0939 (16.0); 8.0754 (0.6); 7.9351 (6.0); 7.9314 (6.4); 7.7363 (2.8); 7.7320 (2.8); 7.7153 (4.0); 7.7108 (4.1); 7.6115 (7.2); 7.5902 (5.2); 4.2648 (1.8); 4.2491 (1.9); 4.2294 (4.1); 4.2136 (3.9); 4.1938 (2.1); 4.1780 (1.9); 4.0384 (0.5); 4.0207 (0.5); 3.3219 (55.9); 2.6714 (0.4); 2.6670 (0.3); 2.5067 (56.1); 2.5024 (73.3); 2.4980 (54.9); 2.3335 (0.3); 2.3290 (0.4); 1.9891 (2.0); 1.1931 (0.5); 1.1754 (1.0); 1.1576 (0.5); 0.0076 (1.7); -0.0003 (37.2)
3-11:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8353 (5.8); 7.5224 (0.5); 7.4827 (1.8); 7.4677 (0.8); 7.4387 (1.4); 7.4069 (2.7); 7.3790 (1.0); 7.3017 (13.9); 6.9504 (0.5); 6.9439 (0.5); 6.9269 (0.3); 4.2575 (1.0); 4.2368 (1.0); 4.2084 (2.0); 4.1877 (2.0); 4.1592 (1.0); 4.1386 (1.0); 3.5389 (0.8); 3.5206 (0.8); 2.5650 (2.9); 2.5579 (5.5); 2.5505 (3.0); 2.3078 (0.5); 2.0492 (10.2); 1.6024 (16.0); 1.2986 (0.3); 0.0500 (0.3); 0.0391 (12.0); 0.0281 (0.4)
3-12:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8705 (16.0); 7.4861 (4.7); 7.4801 (5.1); 7.3663 (2.8); 7.3595 (2.6); 7.3389 (3.3); 7.3322 (3.1); 7.2984 (10.6); 7.0497 (4.7); 7.0223 (4.0); 6.8759 (1.4); 6.8478 (1.5); 5.3975 (0.7); 5.3811 (1.7); 5.3536 (1.8); 5.3339 (0.9); 2.8680 (0.4); 2.8465 (0.3); 2.8312 (1.4); 2.8123 (3.9); 2.7917 (3.6); 2.7716 (1.5); 2.7353 (0.4); 2.2347 (0.5); 2.2171 (0.9); 2.1932 (1.3); 2.1769 (1.4); 2.1636 (1.6); 2.1460 (1.2); 2.1297 (0.4); 2.0441 (0.6); 2.0310 (0.7); 2.0212 (1.2); 2.0091 (1.5); 2.0000 (1.3); 1.9872 (1.2); 1.9797 (1.6); 1.9646 (2.1); 1.9586 (3.1); 1.9442 (3.7); 1.9347 (2.4); 1.9281 (2.7); 1.9127 (2.3); 1.9024 (1.4); 1.8905 (1.1); 1.8771 (0.6); 1.6009 (6.8); 1.2906 (1.7); 0.1064 (2.2); 0.0469 (0.4); 0.0361 (9.6); 0.0251 (0.4)
3-13:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8619 (16.0); 7.3655 (1.8); 7.3589 (2.5); 7.3269 (6.7); 7.2984 (10.2); 7.2396 (5.4); 7.2126 (3.5); 6.8370 (1.4); 6.8094 (1.5); 5.3866 (0.8); 5.3694 (1.8); 5.3498 (1.4); 5.3420 (1.7); 5.3232 (0.9); 2.9024 (0.4); 2.8651 (1.6); 2.8465 (3.4); 2.8285 (3.3); 2.8091 (1.5); 2.2283 (0.4); 2.2151 (0.6); 2.2106 (0.6); 2.1970 (0.8); 2.1850 (1.2); 2.1679 (1.4); 2.1535 (1.5); 2.1442 (0.8); 2.1356 (1.3); 2.1186 (0.4); 2.0649 (0.9); 2.0536 (0.8); 2.0403 (1.1); 2.0297 (1.4); 2.0202 (1.2); 2.0094 (1.2); 1.9976 (1.2); 1.9865 (1.0); 1.9773 (1.6); 1.9617 (1.2); 1.9529 (1.5); 1.9423 (2.0); 1.9327 (2.3); 1.9212 (2.2); 1.9123 (2.3); 1.9008 (1.7); 1.8898 (1.6); 1.8711 (0.8); 1.8597 (0.6); 1.8457 (0.3); 1.6012 (7.3); 1.3028 (1.1); 0.9394 (0.4); 0.9179 (1.1); 0.8946 (0.4); 0.0469 (0.4); 0.0361 (10.5); 0.0251 (0.4)
3-14:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8823 (16.0); 7.4640 (5.0); 7.4248 (2.5); 7.4222 (2.2); 7.4191 (2.0); 7.3979 (3.3); 7.3952 (3.1); 7.3922 (2.9); 7.2986 (11.2); 7.2748 (4.8); 7.2480 (3.4); 6.8431 (1.3); 6.8171 (1.3); 5.6775 (1.0); 5.6523 (2.5); 5.6271 (2.5); 5.6018 (0.9); 3.1369 (0.5); 3.1219 (0.6); 3.1079 (0.5); 3.0917 (0.7); 3.0826 (1.4); 3.0672 (1.6); 3.0534 (1.6); 3.0368 (2.2); 3.0067 (2.6); 2.9803 (1.8); 2.9522 (0.9); 2.9265 (0.6); 2.7997 (0.9); 2.7845 (0.9); 2.7737 (1.6); 2.7580 (1.8); 2.7476 (1.0); 2.7406 (1.1); 2.7299 (2.0); 2.7146 (1.6); 2.7036 (0.9); 2.6884 (0.7); 2.0872 (0.9); 2.0619 (1.5); 2.0584 (1.2); 2.0431 (1.1); 2.0387 (1.4); 2.0352 (1.5); 2.0177 (1.4); 2.0144 (1.2); 2.0099 (1.1); 1.9946 (1.2); 1.9912 (1.2); 1.9657 (0.7); 1.6038 (3.7); 1.2909 (2.7); 1.2654 (0.3); 0.1066 (0.8); 0.0470 (0.4); 0.0363 (10.1); 0.0255 (0.5)
3-15:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8683 (11.0); 7.2985 (6.0); 6.8605 (0.8); 6.8362 (0.8); 6.4732 (3.9); 6.4707 (3.9); 5.3804 (0.5); 5.3649 (1.0); 5.3394 (1.1); 5.3209 (0.5); 4.1560 (0.5); 4.1322 (0.5); 2.6860 (0.4); 2.6699 (0.3); 2.6501 (0.9); 2.6294 (2.3); 2.6044 (1.8); 2.5845 (1.0); 2.5484 (0.4); 2.4601 (16.0); 2.2670 (0.3); 2.2526 (0.5); 2.2358 (0.7); 2.2234 (0.9); 2.2068 (1.0); 2.1926 (0.9); 2.1812 (0.6); 2.1751 (0.8); 2.1669 (0.4); 2.0696 (2.4); 2.0535 (0.4); 2.0418 (0.6); 2.0298 (0.7); 2.0186 (0.9); 2.0111 (0.8); 2.0000 (0.9); 1.9884 (0.6); 1.9717 (0.8); 1.9613 (0.7); 1.9558 (0.6); 1.9396 (0.9); 1.9212 (1.6); 1.9092 (1.4); 1.9005 (1.8); 1.8920 (1.3); 1.8861 (1.5); 1.8805 (1.1); 1.8736 (1.0); 1.8672 (0.9); 1.8548 (0.5); 1.8434 (0.4); 1.6150 (1.8); 1.3429 (0.4); 1.3142 (1.5); 1.3031 (2.5); 1.2908 (2.8); 1.2667 (0.8); 0.9399 (0.9); 0.9181 (2.8); 0.8949 (1.1); 0.1067 (0.7); 0.0362 (5.9)
3-16:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8561 (16.0); 7.2984 (7.6); 7.2557 (4.9); 7.2387 (5.2); 6.9473 (1.2); 6.9218 (1.2); 6.8254 (5.8); 6.8084 (5.4); 5.4719 (0.7); 5.4545 (1.5); 5.4286 (1.5); 5.4095 (0.7); 5.3353 (0.6); 4.1750 (0.6); 4.1512 (1.7); 4.1273 (1.8); 4.1036 (0.6); 2.7816 (0.5); 2.7465 (1.3); 2.7267 (3.6); 2.7040 (3.2); 2.6844 (1.2); 2.6723 (0.4); 2.6478 (0.4); 2.3068 (0.5); 2.2911 (0.8); 2.2736 (0.8); 2.2642 (1.3); 2.2476 (1.4); 2.2341 (1.5); 2.2255 (0.6); 2.2167 (1.1); 2.2024 (0.4); 2.0650 (8.4); 2.0492 (1.1); 2.0373 (1.3); 2.0299 (1.2); 2.0182 (1.2); 2.0092 (1.1); 1.9986 (1.0); 1.9905 (1.5); 1.9758 (2.2); 1.9672 (1.6); 1.9589 (2.8); 1.9469 (2.2); 1.9398 (2.7); 1.9240 (2.2); 1.9194 (1.8); 1.9071 (1.1); 1.8875 (0.6); 1.6183 (2.7); 1.3119 (2.5); 1.2882 (4.8); 1.2643 (2.2); 0.9175 (0.9); 0.8941 (0.4); 0.1061 (0.7); 0.0356 (7.4)
3-17:1 H-NMR(300.2 MHz, CDCl3): δ= 7.8613 (16.0); 7.2984 (9.2); 6.9882 (1.4); 6.9615 (1.4); 6.6367 (11.6); 5.3565 (0.8); 5.3391 (1.7); 5.3174 (1.6); 5.3124 (1.7); 5.2940 (0.8); 4.1526 (0.5); 4.1288 (0.5); 2.6869 (0.5); 2.6511 (1.4); 2.6318 (3.9); 2.6115 (3.7); 2.5923 (1.4); 2.5553 (0.4); 2.5508 (0.4); 2.2852 (0.5); 2.2700 (0.8); 2.2522 (0.8); 2.2425 (1.4); 2.2255 (1.5); 2.2121 (1.5); 2.1943 (1.1); 2.1804 (0.4); 2.0675 (2.2); 2.0498 (0.6); 2.0381 (0.8); 2.0263 (1.1); 2.0148 (1.4); 2.0072 (1.2); 1.9959 (1.3); 1.9861 (1.1); 1.9678 (1.5); 1.9537 (2.3); 1.9462 (1.8); 1.9380 (2.9); 1.9263 (2.2); 1.9184 (3.0); 1.9033 (2.2); 1.8845 (1.4); 1.8763 (0.9); 1.8645 (0.6); 1.8507 (0.3); 1.6115 (4.1); 1.3428 (0.4); 1.3128 (1.4); 1.3020 (2.3); 1.2894 (2.7); 1.2654 (0.8); 0.9389 (0.8); 0.9172 (2.4); 0.8940 (1.0); 0.1055 (0.8); 0.0460 (0.3); 0.0353 (9.0); 0.0244 (0.4)
3-18:1 H-NMR(400.1 MHz, CDCl3): δ= 7.8012 (5.8); 7.6631 (1.8); 7.6432 (2.0); 7.3418 (1.2); 7.3213 (2.5); 7.2905 (1.2); 7.2726 (1.8); 7.2612 (10.2); 7.2548 (1.3); 7.1725 (1.2); 7.1546 (1.8); 7.1368 (0.9); 7.0730 (4.3); 6.6115 (0.6); 6.5943 (0.6); 5.6579 (0.9); 5.6403 (1.3); 5.6226 (0.9); 3.7901 (16.0); 2.9485 (0.6); 2.8693 (0.6); 1.7906 (6.8); 1.7737 (6.9); 1.5703 (10.8); -0.0002 (0.9)
3-19:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3834 (1.6); 7.3569 (1.9); 7.2990 (8.6); 7.0838 (2.1); 7.0653 (1.5); 7.0377 (1.2); 4.2746 (0.8); 4.2536 (0.8); 4.2257 (1.7); 4.2047 (1.6); 4.1767 (0.9); 4.1557 (0.8); 2.5232 (5.7); 2.3723 (16.0); 2.3553 (7.8); 1.5980 (7.5); 1.3034 (0.4); 1.2939 (0.4); 0.9199 (0.4); 0.0488 (0.4); 0.0380 (10.8); 0.0271 (0.4)
3-20:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4993 (1.6); 7.4707 (4.3); 7.4645 (1.7); 7.3795 (1.7); 7.3727 (1.4); 7.3517 (1.0); 7.3450 (0.9); 7.2986 (12.4); 6.8960 (0.4); 6.8760 (0.8); 6.8564 (0.4); 6.1110 (0.4); 6.1019 (0.5); 6.0864 (0.5); 6.0771 (0.4); 5.9548 (0.4); 5.9456 (0.5); 5.9299 (0.5); 5.9207 (0.4); 4.2477 (0.3); 4.2380 (0.3); 4.1520 (0.3); 3.8943 (0.3); 3.8691 (0.4); 3.8439 (0.5); 3.8199 (0.5); 3.7992 (0.3); 2.4254 (16.0); 2.0431 (0.4); 1.6099 (6.8); 1.2929 (0.5); 0.1064 (0.9); 0.0477 (0.5); 0.0369 (13.2); 0.0292 (0.4); 0.0278 (0.4); 0.0260 (0.5)
3-21:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6390 (1.2); 7.6337 (1.9); 7.6289 (1.4); 7.5504 (0.9); 7.5441 (0.8); 7.5224 (1.5); 7.5163 (1.4); 7.4373 (2.2); 7.4096 (1.3); 7.3082 (0.4); 7.2990 (24.2); 6.5330 (0.6); 6.5166 (0.3); 6.0978 (0.4); 6.0891 (0.4); 6.0727 (0.4); 6.0632 (0.4); 5.9415 (0.4); 5.9326 (0.4); 5.9156 (0.4); 5.9069 (0.4); 4.1670 (0.3); 3.8257 (0.5); 3.8071 (0.3); 3.8010 (0.4); 3.5279 (0.4); 2.4213 (16.0); 1.5975 (9.9); 1.2931 (0.7); 0.1071 (1.2); 0.0486 (0.8); 0.0454 (0.4); 0.0378 (27.4); 0.0269 (1.0)
3-22:1 H-NMR(300.2 MHz, CDCl3): δ= 7.3597 (0.5); 7.3403 (0.8); 7.3146 (1.9); 7.2990 (3.5); 7.2885 (2.0); 7.0782 (1.2); 7.0508 (1.1); 7.0375 (1.9); 5.9893 (0.4); 5.9802 (0.4); 5.9616 (0.5); 5.9525 (0.4); 5.8305 (0.4); 5.8213 (0.4); 5.8029 (0.5); 5.7938 (0.4); 4.1209 (0.4); 3.7474 (0.4); 3.7317 (0.4); 3.7153 (0.5); 3.7039 (0.3); 3.6865 (0.4); 2.4418 (16.0); 2.4078 (9.5); 2.3448 (8.2); 2.0403 (0.4); 1.6357 (2.8); 0.0383 (3.9)
3-23:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4014 (1.7); 7.3751 (2.1); 7.2984 (6.9); 7.2373 (2.0); 7.1469 (1.2); 7.1205 (1.0); 7.0648 (0.4); 7.0446 (0.8); 7.0252 (0.4); 6.1127 (0.4); 6.1029 (0.4); 6.0888 (0.5); 6.0787 (0.4); 5.9568 (0.4); 5.9473 (0.4); 5.9329 (0.5); 5.9230 (0.4); 4.2319 (0.3); 4.2216 (0.3); 4.1401 (0.4); 3.9259 (0.4); 3.9203 (0.3); 3.9016 (0.4); 3.8736 (0.5); 3.8549 (0.5); 3.8309 (0.3); 2.4216 (16.0); 2.3636 (9.2); 2.0419 (0.3); 1.6165 (8.0); 0.1062 (0.8); 0.0380 (3.2); 0.0363 (6.6)
3-24:1 H-NMR(300.2 MHz, CDCl3): δ= 7.7793 (0.6); 7.7594 (1.0); 7.7392 (0.6); 7.3541 (2.0); 7.3273 (2.3); 7.2989 (2.1); 7.0556 (2.5); 6.9873 (1.5); 6.9817 (1.3); 6.9604 (1.3); 6.9548 (1.1); 6.0854 (0.4); 6.0752 (0.5); 6.0621 (0.5); 6.0519 (0.4); 5.9299 (0.4); 5.9198 (0.5); 5.9066 (0.5); 5.8964 (0.4); 4.1700 (0.3); 4.0915 (0.3); 3.9478 (0.4); 3.9445 (0.4); 3.9246 (0.3); 3.8951 (0.5); 3.8756 (0.6); 3.8519 (0.3); 2.4191 (16.0); 2.4027 (0.4); 2.0368 (1.0); 1.8954 (0.5); 1.8842 (0.6); 1.8675 (1.1); 1.8558 (0.4); 1.8508 (0.6); 1.8397 (0.6); 1.6884 (0.9); 1.0650 (0.8); 1.0495 (1.8); 1.0430 (2.1); 1.0374 (1.1); 1.0278 (1.1); 1.0212 (1.9); 1.0149 (1.8); 1.0000 (0.9); 0.7232 (0.9); 0.7078 (2.4); 0.7023 (2.0); 0.6913 (2.0); 0.6858 (2.5); 0.6695 (0.7); 0.0350 (2.3)
3-25:1 H-NMR(300.2 MHz, CDCl3): δ= 7.6655 (0.6); 7.6449 (1.2); 7.6244 (0.6); 7.3459 (2.0); 7.3189 (2.3); 7.3003 (1.7); 7.2985 (3.1); 6.9288 (2.5); 6.8999 (1.4); 6.8724 (1.2); 4.2575 (0.8); 4.2365 (0.8); 4.2089 (1.6); 4.1880 (1.6); 4.1603 (0.8); 4.1394 (0.8); 2.5073 (6.7); 2.3586 (16.0); 1.9016 (0.6); 1.8902 (0.6); 1.8738 (1.1); 1.8572 (0.7); 1.8459 (0.6); 1.8289 (0.3); 1.6523 (1.6); 1.0535 (0.8); 1.0384 (2.0); 1.0314 (2.3); 1.0164 (1.2); 1.0099 (2.1); 1.0035 (2.0); 0.9887 (0.9); 0.7385 (0.9); 0.7234 (2.6); 0.7179 (2.3); 0.7068 (2.1); 0.7012 (2.6); 0.6849 (0.7); 0.1077 (0.4); 0.0389 (1.8); 0.0371 (3.3)
3-26:1 H-NMR(300.2 MHz, CDCl3): δ= 7.7186 (1.5); 7.5576 (4.3); 7.5542 (3.9); 7.2987 (24.7); 6.4612 (0.4); 4.4628 (0.6); 4.4416 (0.5); 4.4132 (1.2); 4.3920 (1.1); 4.3628 (1.0); 4.3424 (0.6); 3.5281 (0.5); 2.4043 (10.2); 1.5963 (16.0); 1.2940 (0.6); 0.1067 (2.8); 0.0482 (1.0); 0.0374 (28.6); 0.0283 (0.9); 0.0266 (1.0)
3-27:1 H-NMR(300.2 MHz, CDCl3): δ= 7.9056 (0.5); 7.8848 (1.1); 7.8639 (0.5); 7.4594 (2.1); 7.4326 (2.4); 7.2989 (2.2); 7.2486 (2.2); 7.0700 (1.2); 7.0434 (1.1); 4.4683 (0.8); 4.4471 (0.7); 4.4205 (1.6); 4.3994 (1.6); 4.3728 (0.8); 4.3516 (0.8); 2.3839 (16.0); 2.3346 (8.7); 2.0378 (0.4); 1.6497 (1.9); 0.0354 (2.7)
3-28:1 H-NMR(300.2 MHz, CDCl3): δ= 7.4883 (0.7); 7.4398 (0.5); 7.4104 (1.1); 7.3826 (0.4); 7.2989 (18.5); 4.2725 (0.4); 4.2511 (0.3); 4.2226 (0.7); 4.2014 (0.7); 4.1726 (0.4); 4.1518 (0.4); 2.5703 (2.2); 2.5635 (1.2); 2.3771 (6.6); 2.0466 (0.3); 1.5857 (16.0); 1.2928 (0.7); 0.0484 (0.8); 0.0377 (24.8); 0.0268 (1.0)
表9：根據式(4)之化合物
Figure 02_image091
Ex N° A QS LogP
4-01 CH 丙-1-烯-1-基 2.33[a]
4-02 CH 環丙基 2.12[a]
4-03 CH 乙烯基 1.96[a]
4-04 CH 乙炔基 1.72[a]
4-05 CH  rac-2,2-二氟環丙基   
4-06 CH 1-氟環丙基   
表10：
4-01:1 H-NMR(499.9 MHz, CDCl3): δ= 7.3302 (0.3); 7.2563 (7.5); 6.9959 (2.3); 6.9937 (2.2); 6.9796 (5.4); 6.9781 (5.6); 6.9641 (3.7); 6.9622 (4.0); 6.9399 (3.1); 6.9294 (2.7); 6.9259 (2.0); 6.9094 (2.9); 6.9062 (3.5); 6.8931 (4.7); 6.8899 (5.3); 6.8767 (2.1); 6.8736 (2.2); 6.8480 (0.8); 6.8409 (3.0); 6.8383 (3.4); 6.8259 (5.3); 6.8183 (1.0); 6.8125 (2.7); 6.5247 (0.7); 6.5216 (0.8); 6.4929 (1.0); 6.4898 (1.1); 6.4244 (3.3); 6.4013 (3.6); 6.3514 (0.4); 6.3382 (1.1); 6.3249 (1.0); 6.3116 (0.4); 6.3064 (0.8); 6.2931 (0.8); 5.9560 (1.3); 5.9418 (3.8); 5.9330 (1.3); 5.9276 (3.9); 5.9188 (3.6); 5.9135 (1.5); 5.9046 (3.5); 5.8904 (1.2); 5.1702 (0.6); 5.1565 (0.6); 5.1063 (0.8); 2.0489 (0.8); 1.9189 (3.6); 1.9158 (3.7); 1.9056 (3.6); 1.9025 (3.7); 1.8255 (9.5); 1.8226 (16.0); 1.8196 (10.8); 1.8113 (9.8); 1.8083 (16.0); 1.8055 (10.6); 1.2596 (0.4); 1.2511 (0.5); 0.0813 (0.7); -0.0002 (9.1)
4-02:1 H-NMR(300.1 MHz, d6 -DMSO): δ= 9.6264 (16.0); 6.8628 (2.1); 6.8591 (2.1); 6.8364 (5.2); 6.8326 (5.3); 6.8101 (3.6); 6.8066 (3.8); 6.7434 (3.5); 6.7378 (3.8); 6.7159 (5.1); 6.7104 (5.3); 6.6887 (2.4); 6.6832 (2.3); 6.3737 (2.6); 6.3684 (2.6); 6.3475 (4.7); 6.3262 (2.4); 6.3211 (2.2); 5.7578 (0.4); 4.0415 (0.8); 4.0178 (0.9); 3.3382 (6.7); 2.5154 (2.8); 2.5095 (5.4); 2.5036 (7.2); 2.4976 (4.9); 2.4918 (2.2); 2.0462 (0.7); 2.0289 (1.6); 2.0180 (1.8); 2.0009 (3.3); 1.9896 (5.1); 1.9730 (1.8); 1.9556 (0.9); 1.1988 (1.0); 1.1751 (2.1); 1.1513 (1.0); 0.9636 (2.7); 0.9495 (7.4); 0.9420 (7.8); 0.9356 (3.5); 0.9287 (4.0); 0.9210 (7.8); 0.9136 (7.1); 0.9005 (3.3); 0.8787 (0.4); 0.7131 (0.3); 0.6811 (3.5); 0.6678 (8.1); 0.6606 (8.4); 0.6506 (7.8); 0.6434 (8.0); 0.6289 (2.6); -0.0004 (5.8)
4-03:1 H-NMR(300.2 MHz, CDCl3): δ= 7.2988 (8.3); 7.0822 (1.8); 7.0748 (2.4); 7.0563 (7.2); 7.0491 (7.3); 7.0406 (18.4); 7.0294 (8.8); 7.0183 (16.0); 7.0042 (0.7); 6.9921 (5.6); 6.9704 (6.4); 6.9630 (5.7); 6.9437 (7.8); 6.9375 (3.4); 6.9324 (4.6); 6.9257 (7.2); 6.9223 (4.7); 6.9109 (3.1); 6.8885 (6.8); 6.8667 (7.3); 6.8294 (7.6); 5.8978 (11.2); 5.8944 (11.6); 5.8387 (10.0); 5.8353 (10.3); 5.4557 (11.1); 5.4523 (11.2); 5.4184 (10.5); 5.4150 (10.7); 5.3378 (12.9); 5.2491 (9.5); 4.1831 (0.6); 4.1593 (0.6); 2.0946 (2.9); 1.6957 (8.4); 1.3266 (1.2); 1.3201 (1.8); 1.3029 (3.6); 1.2968 (3.9); 1.2790 (1.0); 1.2733 (1.4); 1.2639 (0.5); 0.9451 (0.6); 0.9234 (1.7); 0.9002 (0.7); 0.3136 (0.6); 0.3114 (0.6); 0.1135 (0.5); 0.0418 (9.8); 0.0309 (0.3)
4-04:1 H-NMR(300.2 MHz, d6 -DMSO): δ= 10.1443 (10.6); 7.0557 (1.1); 7.0475 (1.7); 7.0294 (5.0); 7.0208 (9.2); 7.0121 (10.7); 6.9957 (16.0); 6.9697 (3.6); 6.9611 (5.2); 6.9532 (4.8); 6.9420 (4.8); 6.9372 (2.6); 6.9281 (4.3); 6.9105 (2.0); 5.7720 (0.5); 4.4390 (15.0); 3.3732 (6.7); 2.5346 (1.0); 2.5286 (2.1); 2.5226 (2.9); 2.5166 (2.1); 2.5107 (1.0); 2.1030 (9.3); 2.0061 (0.8); 1.2540 (0.8); 1.1910 (0.5); 1.0987 (0.3); 1.0754 (0.7); 1.0521 (0.3); 0.8709 (0.6); 0.0130 (3.7)
4-05:1 H-NMR(300.2 MHz, CDCl3): δ= 7.2988 (0.5); 7.0418 (0.4); 7.0149 (1.2); 6.9891 (2.4); 6.9810 (1.1); 6.9623 (0.9); 6.9569 (0.9); 6.9354 (0.3); 6.7340 (0.4); 6.7264 (0.4); 6.7100 (0.8); 6.6868 (0.4); 6.6841 (0.4); 5.4977 (1.0); 5.3330 (0.8); 2.8803 (0.3); 2.8674 (0.6); 2.8398 (0.6); 2.8264 (0.4); 2.7988 (0.3); 2.0439 (16.0); 1.9405 (0.4); 1.9265 (0.6); 1.9103 (0.5); 1.9009 (0.6); 1.8842 (0.6); 1.8612 (0.4); 1.8442 (0.4); 1.7154 (0.3); 1.7014 (0.5); 1.6880 (0.7); 1.6738 (0.5); 1.6597 (0.7); 1.6462 (0.6); 0.0359 (0.7)
4-06:1 H-NMR(300.2 MHz, CDCl3): δ= 7.2989 (22.6); 7.1680 (0.4); 7.1558 (0.6); 7.1500 (0.9); 7.1325 (1.2); 7.1213 (0.4); 7.1047 (1.8); 7.0896 (1.0); 7.0770 (4.3); 7.0605 (33.6); 7.0549 (23.8); 7.0432 (11.9); 7.0398 (16.0); 7.0347 (9.4); 7.0256 (4.5); 7.0210 (3.8); 7.0125 (2.1); 7.0074 (1.9); 7.0039 (1.9); 5.1920 (11.4); 3.6842 (0.4); 3.3468 (0.4); 2.1527 (0.4); 2.1394 (0.3); 2.1195 (0.3); 2.1161 (0.3); 2.0859 (0.3); 2.0500 (0.4); 1.6703 (0.4); 1.6596 (0.6); 1.6394 (7.8); 1.5230 (3.1); 1.5003 (9.4); 1.4973 (10.4); 1.4743 (4.2); 1.4603 (3.2); 1.4377 (9.4); 1.4345 (10.3); 1.4116 (4.9); 1.3500 (0.5); 1.2497 (0.7); 1.2391 (0.5); 1.2200 (0.8); 1.1889 (4.2); 1.1732 (5.5); 1.1681 (11.0); 1.1612 (12.7); 1.1386 (13.2); 1.1327 (9.8); 1.1110 (3.1); 0.0502 (0.9); 0.0394 (29.9); 0.0285 (1.1)
生物製劑實例
實例 ： 對芸苔鏈格孢 ( Alternaria brassicae ) ( 蘿蔔或甘藍菜之葉斑病 ) 之活體內預防性測試 溶劑：5%按二甲亞碸之體積計 10%   按丙酮之體積計 乳化劑：每毫克活性成分1 µl之Tween® 80
活性成分在二甲亞碸/丙酮/Tween® 80之混合物中可溶且均質化，且隨後在水中稀釋至所需濃度。
藉由噴灑如上文所述製備之活性成份處理蘿蔔或甘藍菜之幼株。僅用丙酮/二甲亞碸/Tween® 80之水溶液處理對照植物。
在24小時之後，藉由用芸苔鏈格孢孢子之水性懸浮液噴灑葉片來污染植物。在20℃下且在100%相對濕度下將受污染之蘿蔔或甘藍菜植物培育6天。
在接種後6天對測試進行評估。0%意謂對應於對照植物之功效的功效，而100%之功效意謂未觀測到病害。
在此測試中，以下根據本發明之化合物在500 ppm活性成份之濃度下顯示在70%與79%之間的功效： I-018; I-019; I-038; I-069; I-123; I-177; I-180; I-208; I-234; I-239; I-278; I-289; I-316; I-318; I-392; I-431; I-432; I-437; I-468; I-482; I-488; I-489; I-515; I-565; I-678; I-721; I-821
在此測試中，在500 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-004；I-005；I-013；I-031；I-032；I-043；I-068；I-071；I-095；I-109；I-110；I-145；I-157；I-170；I-183；I-220；I-235；I-241；I-262；I-269；I-271；I-298；I-306；I-307；I-328；I-335；I-340；I-349；I-368；I-381；I-394；I-416；I-425；I-427；I-429；I-456；I-465；I-467；I-475；I-495；I-517；I-523；I-539；I-542；I-547；I-558；I-564；I-568；I-585；I-586；I-590；I-600；I-602；I-635；I-642；I-657；I-679；I-688；I-739；I-768；I-777；I-795；I-797；I-814；I-825
在此測試中，根據本發明之以下化合物在500 ppm活性成分之濃度下展示90%與100%之間的功效： I-001；I-002；I-003；I-007；I-009；I-011；I-012；I-014；I-015；I-017；I-020；I-021；I-022；I-023；I-024；I-025；I-026；I-027；I-028；I-029；I-030；I-033；I-034；I-035；I-036；I-037；I-040；I-042；I-044；I-045；I-046；I-047；I-048；I-049；I-050；I-051；I-053；I-054；I-056；I-057；I-058；I-059；I-060；I-061；I-062；I-063；I-066；I-070；I-072；I-073；I-074；I-075；I-077；I-078；I-079；I-080；I-081；I-082；I-083；I-084；I-085；I-086；I-087；I-090；I-091；I-092；I-093；I-094；I-096；I-097；I-098；I-101；I-102；I-103；I-105；I-106；I-107；I-108；I-111；I-112；I-113；I-114；I-115；I-116；I-117；I-118；I-119；I-120；I-121；I-122；I-124；I-126；I-128；I-129；I-130；I-131；I-132；I-134；I-135；I-136；I-138；I-139；I-140；I-141；I-142；I-143；I-144；I-146；I-147；I-148；I-150；I-151；I-152；I-153；I-154；I-155；I-156；I-158；I-159；I-160；I-161；I-162；I-165；I-166；I-167；I-168；I-169；I-171；I-172；I-173；I-174；I-175；I-178；I-179；I-181；I-182；I-184；I-185；I-186；I-187；I-188；I-189；I-190；I-191；I-193；I-194；I-195；I-196；I-197；I-198；I-199；I-200；I-201；I-203；I-204；I-205；I-206；I-207；I-209；I-210；I-211；I-212；I-213；I-214；I-215；I-216；I-217；I-219；I-221；I-222；I-223；I-224；I-226；I-227；I-228；I-229；I-231；I-233；I-236；I-237；I-238；I-240；I-242；I-244；I-245；I-246；I-247；I-248；I-249；I-252；I-253；I-254；I-255；I-256；I-257；I-258；I-259；I-261；I-263；I-264；I-266；I-267；I-268；I-270；I-273；I-274；I-275；I-276；I-277；I-279；I-280；I-281；I-282；I-283；I-284；I-285；I-288；I-290；I-291；I-293；I-294；I-295；I-296；I-300；I-301；I-302；I-303；I-304；I-305；I-309；I-310；I-311；I-312；I-313；I-314；I-315；I-317；I-319；I-321；I-322；I-323；I-324；I-325；I-327；I-329；I-330；I-331；I-332；I-334；I-336；I-337；I-338；I-339；I-342；I-343；I-344；I-345；I-346；I-347；I-348；I-350；I-352；I-353；I-356；I-357；I-358；I-359；I-360；I-361；I-362；I-364；I-365；I-366；I-367；I-369；I-370；I-371；I-372；I-373；I-374；I-375；I-377；I-378；I-379；I-380；I-382；I-383；I-384；I-385；I-387；I-388；I-389；I-391；I-393；I-395；I-396；I-398；I-399；I-400；I-401；I-402；I-403；I-404；I-405；I-407；I-408；I-409；I-410；I-411；I-413；I-414；I-415；I-418；I-419；I-420；I-421；I-422；I-423；I-424；I-426；I-428；I-430；I-433；I-434；I-435；I-436；I-438；I-439；I-440；I-441；I-442；I-443；I-444；I-445；I-446；I-447；I-448；I-449；I-450；I-451；I-452；I-453；I-454；I-455；I-457；I-458；I-460；I-461；I-462；I-463；I-464；I-466；I-470；I-471；I-472；I-473；I-474；I-476；I-477；I-478；I-480；I-481；I-483；I-484；I-486；I-487；I-490；I-493；I-494；I-496；I-497；I-498；I-499；I-500；I-501；I-502；I-503；I-504；I-506；I-507；I-508；I-509；I-510；I-511；I-512；I-513；I-514；I-516；I-520；I-521；I-522；I-524；I-525；I-526；I-527；I-528；I-529；I-530；I-531；I-532；I-533；I-534；I-535；I-536；I-537；I-541；I-543；I-544；I-545；I-546；I-549；I-550；I-551；I-552；I-553；I-554；I-555；I-556；I-557；I-560；I-561；I-562；I-563；I-566；I-567；I-570；I-571；I-572；I-573；I-574；I-575；I-577；I-578；I-579；I-580；I-581；I-582；I-583；I-587；I-588；I-589；I-591；I-592；I-593；I-594；I-595；I-596；I-597；I-598；I-599；I-601；I-603；I-604；I-605；I-606；I-607；I-608；I-609；I-610；I-611；I-612；I-613；I-614；I-615；I-616；I-617；I-618；I-619；I-620；I-621；I-622；I-623；I-624；I-625；I-626；I-627；I-628；I-629；I-630；I-631；I-632；I-634；I-636；I-637；I-638；I-639；I-640；I-641；I-643；I-644；I-645；I-646；I-647；I-648；I-649；I-650；I-651；I-652；I-653；I-654；I-655；I-656；I-658；I-659；I-660；I-661；I-662；I-665；I-666；I-674；I-675；I-676；I-677；I-680；I-681；I-682；I-683；I-684；I-685；I-686；I-687；I-689；I-690；I-691；I-693；I-694；I-695；I-696；I-697；I-698；I-699；I-700；I-701；I-702；I-703；I-704；I-705；I-706；I-707；I-708；I-709；I-710；I-711；I-712；I-713；I-714；I-715；I-716；I-717；I-718；I-719；I-720；I-722；I-723；I-724；I-725；I-726；I-727；I-728；I-729；I-730；I-731；I-732；I-733；I-734；I-735；I-736；I-737；I-738；I-740；I-741；I-742；I-743；I-744；I-745；I-748；I-749；I-750；I-752；I-753；I-754；I-755；I-756；I-757；I-759；I-760；I-761；I-762；I-763；I-767；I-770；I-771；I-772；I-773；I-775；I-776；I-779；I-780；I-781；I-782；I-783；I-784；I-786；I-787；I-788；I-789；I-790；I-791；I-794；I-796；I-800；I-801；I-802；I-803；I-804；I-805；I-806；I-807；I-808；I-809；I-810；I-812；I-815；I-816；I-817；I-818；I-819；I-820；I-822；I-823；I-824；I-827；I-828；I-830；I-831；I-832；I-834
實例 ： 對灰葡萄孢菌 ( 灰黴 ) 之活體內預防性測試 溶劑：5%按二甲亞碸之體積計 10%   按丙酮之體積計 乳化劑：每毫克活性成分1 µl之Tween® 80
活性成分在二甲亞碸/丙酮/Tween® 80之混合物中可溶且均質化，且隨後在水中稀釋至所需濃度。
藉由噴灑如上文所述製備之活性成份處理小黃瓜或甘藍菜之幼株。僅用丙酮/二甲亞碸/Tween® 80之水溶液處理對照植物。
在24小時之後，植株因用灰葡萄孢菌孢子之水性懸浮液噴灑葉片而受到污染。在17℃下且在90%相對濕度下將受污染之小黃瓜植物培育4至5天。經污染之甘藍菜植株在20℃下且在100%之相對濕度下培育4至5天。
在接種後4至5天對測試進行評估。0%意謂對應於對照植物之功效的功效，而100%之功效意謂未觀測到病害。
在此測試中，以下根據本發明之化合物在500 ppm活性成份之濃度下顯示在70%與79%之間的功效： I-091; I-109; I-131; I-138; I-155; I-163; I-220; I-252; I-268; I-306; I-326; I-354; I-355; I-439; I-605; I-625; I-638; I-661; I-737
在此測試中，在500 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-013；I-047；I-049；I-062；I-089；I-125；I-149；I-150；I-157；I-166；I-177；I-244；I-271；I-280；I-302；I-346；I-352；I-390；I-406；I-426；I-444；I-479；I-491；I-492；I-493；I-501；I-518；I-532；I-560；I-569；I-575；I-595；I-597；I-600；I-633；I-641；I-753；I-830
在此測試中，根據本發明之以下化合物在500 ppm活性成分之濃度下展示90%與100%之間的功效： I-001；I-002；I-003；I-004；I-005；I-007；I-008；I-009；I-010；I-011；I-012；I-014；I-015；I-016；I-017；I-018；I-019；I-020；I-021；I-022；I-023；I-024；I-025；I-026；I-027；I-028；I-029；I-030；I-031；I-032；I-033；I-034；I-035；I-036；I-037；I-038；I-039；I-040；I-042；I-043；I-044；I-045；I-046；I-048；I-050；I-051；I-052；I-053；I-054；I-056；I-057；I-058；I-059；I-060；I-061；I-063；I-064；I-065；I-066；I-067；I-069；I-070；I-071；I-072；I-073；I-074；I-075；I-076；I-077；I-078；I-079；I-080；I-081；I-082；I-083；I-084；I-085；I-086；I-087；I-088；I-090；I-092；I-093；I-094；I-096；I-099；I-100；I-101；I-103；I-104；I-105；I-106；I-107；I-108；I-110；I-112；I-113；I-114；I-115；I-117；I-118；I-119；I-120；I-121；I-122；I-124；I-126；I-127；I-128；I-129；I-130；I-132；I-133；I-134；I-135；I-136；I-137；I-139；I-140；I-141；I-142；I-143；I-144；I-145；I-146；I-147；I-148；I-151；I-152；I-153；I-154；I-158；I-159；I-160；I-161；I-162；I-165；I-167；I-168；I-169；I-170；I-171；I-172；I-173；I-174；I-175；I-176；I-179；I-180；I-181；I-182；I-183；I-184；I-185；I-186；I-187；I-188；I-189；I-190；I-191；I-192；I-193；I-194；I-195；I-196；I-197；I-198；I-199；I-200；I-201；I-203；I-204；I-205；I-206；I-207；I-209；I-210；I-211；I-212；I-213；I-214；I-215；I-216；I-217；I-218；I-219；I-221；I-222；I-223；I-224；I-225；I-226；I-227；I-228；I-229；I-230；I-231；I-232；I-233；I-234；I-235；I-236；I-237；I-238；I-240；I-241；I-242；I-245；I-246；I-248；I-249；I-251；I-253；I-254；I-255；I-256；I-257；I-258；I-259；I-260；I-261；I-262；I-263；I-264；I-266；I-267；I-269；I-272；I-273；I-274；I-275；I-276；I-277；I-281；I-282；I-283；I-284；I-285；I-286；I-287；I-288；I-289；I-290；I-291；I-292；I-293；I-294；I-295；I-296；I-297；I-298；I-300；I-301；I-303；I-304；I-305；I-307；I-308；I-309；I-310；I-311；I-312；I-313；I-314；I-315；I-316；I-317；I-318；I-319；I-320；I-321；I-322；I-323；I-324；I-325；I-327；I-328；I-329；I-330；I-331；I-332；I-334；I-335；I-336；I-337；I-338；I-339；I-340；I-342；I-343；I-344；I-345；I-347；I-348；I-350；I-353；I-356；I-357；I-358；I-359；I-360；I-362；I-363；I-364；I-365；I-366；I-367；I-368；I-369；I-370；I-371；I-372；I-373；I-374；I-375；I-376；I-377；I-378；I-379；I-380；I-382；I-383；I-384；I-385；I-386；I-387；I-389；I-391；I-392；I-393；I-394；I-395；I-396；I-397；I-398；I-399；I-400；I-401；I-403；I-404；I-405；I-407；I-408；I-409；I-410；I-411；I-412；I-413；I-415；I-416；I-417；I-418；I-419；I-420；I-421；I-422；I-423；I-424；I-425；I-427；I-428；I-429；I-430；I-431；I-434；I-435；I-437；I-438；I-440；I-441；I-442；I-443；I-445；I-446；I-447；I-448；I-449；I-450；I-451；I-452；I-453；I-455；I-456；I-457；I-458；I-459；I-460；I-461；I-462；I-463；I-464；I-467；I-468；I-469；I-470；I-471；I-472；I-473；I-474；I-477；I-478；I-480；I-481；I-482；I-483；I-484；I-486；I-488；I-490；I-494；I-496；I-497；I-498；I-499；I-500；I-502；I-503；I-504；I-505；I-506；I-507；I-508；I-509；I-510；I-511；I-513；I-514；I-515；I-516；I-517；I-519；I-520；I-521；I-522；I-523；I-524；I-525；I-526；I-528；I-529；I-530；I-531；I-533；I-534；I-536；I-537；I-538；I-539；I-540；I-543；I-544；I-545；I-546；I-547；I-548；I-549；I-550；I-551；I-552；I-553；I-554；I-555；I-556；I-557；I-558；I-561；I-562；I-564；I-565；I-566；I-567；I-568；I-570；I-571；I-572；I-573；I-574；I-577；I-578；I-579；I-580；I-581；I-582；I-583；I-584；I-586；I-587；I-588；I-589；I-590；I-591；I-592；I-593；I-594；I-596；I-598；I-599；I-601；I-602；I-603；I-604；I-606；I-607；I-608；I-610；I-612；I-613；I-614；I-615；I-616；I-617；I-618；I-619；I-620；I-621；I-622；I-623；I-624；I-626；I-627；I-628；I-629；I-630；I-631；I-632；I-634；I-635；I-636；I-637；I-639；I-640；I-642；I-643；I-644；I-645；I-646；I-648；I-649；I-650；I-651；I-652；I-653；I-655；I-656；I-657；I-658；I-659；I-662；I-665；I-666；I-674；I-675；I-677；I-678；I-679；I-680；I-681；I-682；I-683；I-684；I-685；I-686；I-687；I-688；I-689；I-690；I-691；I-693；I-694；I-695；I-696；I-697；I-698；I-699；I-700；I-701；I-702；I-703；I-704；I-705；I-706；I-707；I-708；I-709；I-710；I-711；I-712；I-713；I-714；I-715；I-716；I-717；I-718；I-719；I-720；I-721；I-722；I-723；I-724；I-725；I-726；I-727；I-729；I-730；I-731；I-732；I-733；I-734；I-735；I-736；I-739；I-740；I-741；I-742；I-743；I-744；I-745；I-748；I-749；I-750；I-752；I-754；I-755；I-756；I-757；I-759；I-760；I-761；I-762；I-764；I-765；I-766；I-767；I-768；I-769；I-770；I-771；I-772；I-773；I-775；I-776；I-777；I-779；I-780；I-781；I-782；I-783；I-784；I-785；I-786；I-787；I-788；I-789；I-790；I-791；I-792；I-793；I-794；I-795；I-796；I-797；I-798；I-800；I-802；I-803；I-804；I-805；I-806；I-807；I-808；I-809；I-810；I-811；I-812；I-813；I-814；I-815；I-816；I-817；I-818；I-820；I-821；I-822；I-823；I-824；I-825；I-827；I-831；I-832；I-834
實例 ： 對大麥網斑病菌 ( 大麥網斑病 ) 之活體內預防性測試 溶劑：5%按二甲亞碸之體積計 10%   按丙酮之體積計 乳化劑：每毫克活性成分1 µl之Tween® 80
活性成分在二甲亞碸/丙酮/Tween® 80之混合物中可溶且均質化，且隨後在水中稀釋至所需濃度。
藉由噴灑如上文所述製備之活性成份處理大麥之幼株。僅用丙酮/二甲亞碸/Tween® 80之水溶液處理對照植物。
在24小時之後，藉由用大麥網斑病菌孢子之水性懸浮液噴灑葉子來污染植株。將經污染之大麥植物在20℃下且在100%相對濕度下培育48小時，隨後在20℃下且在70-80%相對濕度下培育8天。
在接種後10天對測試進行評估。0%意謂對應於對照植物之功效的功效，而100%之功效意謂未觀測到病害。
在此測試中，以下根據本發明之化合物在500 ppm活性成份之濃度下顯示在70%與79%之間的功效： I-007；I-013；I-014；I-032；I-058；I-060；I-077；I-090；I-096；I-124；I-126；I-128；I-136；I-139；I-145；I-147；I-176；I-200；I-209；I-217；I-223；I-225；I-235；I-240；I-241；I-262；I-275；I-279；I-281；I-282；I-292；I-321；I-324；I-330；I-334；I-350；I-366；I-372；I-395；I-398；I-404；I-405；I-408；I-413；I-441；I-458；I-459；I-467；I-468；I-496；I-514；I-530；I-575；I-581；I-584；I-592；I-605；I-611；I-617；I-622；I-630；I-631；I-638；I-640；I-641；I-643；I-648；I-653；I-665；I-682；I-696；I-698；I-715；I-725；I-742；I-770；I-777；I-789；I-816；I-820
在此測試中，在500 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-001；I-009；I-012；I-017；I-020；I-024；I-028；I-030；I-036；I-045；I-053；I-056；I-062；I-074；I-075；I-086；I-094；I-108；I-114；I-117；I-122；I-131；I-134；I-143；I-144；I-150；I-167；I-184；I-186；I-194；I-195；I-196；I-205；I-210；I-211；I-215；I-219；I-229；I-242；I-245；I-255；I-256；I-276；I-283；I-286；I-288；I-297；I-301；I-303；I-304；I-311；I-313；I-319；I-322；I-328；I-332；I-336；I-344；I-348；I-363；I-369；I-370；I-371；I-375；I-377；I-384；I-396；I-401；I-403；I-409；I-417；I-433；I-443；I-445；I-455；I-461；I-464；I-474；I-480；I-494；I-508；I-528；I-533；I-543；I-551；I-567；I-568；I-577；I-589；I-598；I-606；I-607；I-613；I-616；I-619；I-621；I-624；I-629；I-634；I-637；I-645；I-662；I-680；I-687；I-690；I-702；I-703；I-706；I-714；I-720；I-722；I-729；I-732；I-735；I-736；I-744；I-756；I-762；I-767；I-779；I-780；I-784；I-786；I-787；I-796；I-809；I-810；I-832
在此測試中，根據本發明之以下化合物在500 ppm活性成分之濃度下展示90%與100%之間的功效： I-002；I-003；I-029；I-040；I-044；I-047；I-050；I-054；I-063；I-070；I-084；I-085；I-092；I-101；I-142；I-151；I-152；I-153；I-159；I-160；I-171；I-175；I-180；I-187；I-189；I-190；I-191；I-197；I-204；I-247；I-248；I-259；I-264；I-267；I-284；I-293；I-312；I-327；I-337；I-342；I-347；I-358；I-359；I-365；I-374；I-380；I-383；I-385；I-389；I-410；I-411；I-415；I-423；I-424；I-435；I-446；I-447；I-457；I-477；I-481；I-497；I-499；I-503；I-506；I-536；I-544；I-552；I-555；I-556；I-563；I-571；I-574；I-579；I-587；I-590；I-594；I-604；I-612；I-625；I-632；I-644；I-655；I-660；I-681；I-709；I-710；I-711；I-712；I-713；I-726；I-730；I-731；I-734；I-748；I-749；I-750；I-757；I-761；I-763；I-773；I-775；I-776；I-783；I-802；I-805；I-806；I-807；I-808；I-812；I-817；I-822；I-823；I-831；I-834
實例 ： 對單絲殼白粉菌 ( 葫蘆白粉病 ) 之活體內預防性測試 溶劑：5%按二甲亞碸之體積計 10%   按丙酮之體積計 乳化劑：每毫克活性成分1 µl之Tween® 80
活性成分在二甲亞碸/丙酮/Tween® 80之混合物中可溶且均質化，且隨後在水中稀釋至所需濃度。
藉由噴灑如上文所述製備之活性成份處理小黃瓜之幼株。僅用丙酮/二甲亞碸/Tween® 80之水溶液處理對照植物。
在24小時之後，植株因用單絲殼白粉菌孢子之水性懸浮液噴灑葉片而受到污染。在20℃下且在70-80%相對濕度下將受污染之小黃瓜植物培育8天。
在接種後8天對測試進行評價。0%意謂對應於對照植物之功效的功效，而100%之功效意謂未觀測到病害。
在此測試中，以下根據本發明之化合物在500 ppm活性成份之濃度下顯示在70%與79%之間的功效： I-059; I-078; I-235; I-282; I-287; I-313; I-466; I-473; I-519; I-538; I-541; I-542; I-545; I-548; I-675; I-677; I-729; I-745; I-800
在此測試中，在500 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-066; I-076; I-095; I-099; I-108; I-138; I-195; I-261; I-270; I-277; I-294; I-335; I-351; I-354; I-397; I-399; I-426; I-451; I-483; I-484; I-508; I-513; I-564; I-577; I-603; I-618; I-648; I-666; I-759
在此測試中，根據本發明之以下化合物在500 ppm活性成分之濃度下展示90%與100%之間的功效： I-001；I-002；I-003；I-004；I-005；I-007；I-009；I-011；I-012；I-013；I-014；I-015；I-017；I-018；I-019；I-020；I-021；I-022；I-023；I-024；I-026；I-027；I-028；I-029；I-030；I-032；I-033；I-034；I-035；I-036；I-037；I-038；I-040；I-042；I-044；I-045；I-047；I-048；I-050；I-052；I-053；I-054；I-057；I-061；I-062；I-063；I-064；I-067；I-068；I-070；I-072；I-073；I-074；I-075；I-077；I-079；I-081；I-082；I-084；I-085；I-086；I-090；I-092；I-093；I-094；I-096；I-100；I-101；I-103；I-104；I-106；I-107；I-110；I-112；I-113；I-114；I-115；I-117；I-119；I-121；I-122；I-124；I-126；I-128；I-129；I-130；I-133；I-134；I-135；I-136；I-137；I-140；I-142；I-143；I-144；I-145；I-146；I-147；I-149；I-150；I-151；I-152；I-153；I-156；I-157；I-159；I-160；I-161；I-162；I-163；I-165；I-167；I-168；I-171；I-172；I-174；I-175；I-176；I-177；I-179；I-180；I-181；I-182；I-186；I-187；I-188；I-189；I-190；I-191；I-192；I-193；I-194；I-196；I-197；I-198；I-200；I-202；I-203；I-204；I-207；I-208；I-209；I-210；I-211；I-212；I-213；I-214；I-215；I-217；I-218；I-219；I-221；I-222；I-223；I-224；I-225；I-226；I-231；I-233；I-234；I-236；I-238；I-240；I-241；I-242；I-244；I-245；I-246；I-247；I-248；I-249；I-253；I-254；I-255；I-256；I-257；I-258；I-259；I-260；I-262；I-263；I-264；I-266；I-267；I-269；I-271；I-272；I-273；I-274；I-275；I-276；I-278；I-279；I-280；I-281；I-283；I-284；I-285；I-286；I-288；I-289；I-290；I-293；I-295；I-296；I-301；I-303；I-304；I-305；I-307；I-308；I-311；I-312；I-314；I-315；I-317；I-319；I-320；I-321；I-322；I-323；I-324；I-327；I-328；I-329；I-332；I-333；I-336；I-337；I-338；I-340；I-341；I-342；I-343；I-344；I-345；I-346；I-347；I-348；I-349；I-350；I-352；I-353；I-355；I-356；I-357；I-358；I-359；I-360；I-361；I-362；I-364；I-365；I-366；I-367；I-368；I-369；I-370；I-371；I-372；I-373；I-374；I-375；I-377；I-378；I-380；I-382；I-383；I-384；I-385；I-387；I-389；I-391；I-393；I-395；I-396；I-398；I-400；I-401；I-402；I-403；I-404；I-405；I-407；I-408；I-409；I-411；I-412；I-413；I-414；I-415；I-416；I-418；I-420；I-422；I-424；I-425；I-428；I-430；I-432；I-433；I-434；I-435；I-437；I-438；I-440；I-441；I-442；I-443；I-444；I-445；I-446；I-447；I-452；I-453；I-454；I-455；I-457；I-458；I-459；I-460；I-461；I-462；I-464；I-467；I-468；I-469；I-470；I-474；I-476；I-477；I-478；I-479；I-480；I-481；I-487；I-490；I-493；I-495；I-496；I-497；I-498；I-499；I-500；I-502；I-503；I-504；I-505；I-506；I-510；I-514；I-516；I-520；I-521；I-522；I-524；I-528；I-529；I-530；I-531；I-533；I-534；I-536；I-543；I-544；I-546；I-547；I-549；I-550；I-552；I-553；I-554；I-555；I-556；I-557；I-561；I-563；I-565；I-566；I-567；I-568；I-569；I-570；I-571；I-572；I-574；I-579；I-581；I-582；I-583；I-587；I-589；I-590；I-592；I-594；I-595；I-596；I-598；I-604；I-605；I-606；I-607；I-609；I-611；I-612；I-613；I-615；I-616；I-619；I-620；I-621；I-622；I-624；I-625；I-626；I-629；I-630；I-631；I-632；I-633；I-636；I-637；I-638；I-640；I-642；I-644；I-645；I-646；I-649；I-651；I-653；I-655；I-656；I-657；I-659；I-662；I-665；I-674；I-678；I-679；I-681；I-683；I-684；I-687；I-688；I-689；I-690；I-693；I-694；I-695；I-696；I-699；I-700；I-702；I-703；I-704；I-706；I-707；I-708；I-709；I-710；I-711；I-712；I-713；I-714；I-715；I-716；I-717；I-718；I-719；I-720；I-722；I-723；I-724；I-725；I-726；I-727；I-730；I-731；I-732；I-734；I-735；I-736；I-737；I-738；I-739；I-741；I-742；I-743；I-744；I-748；I-749；I-750；I-752；I-755；I-756；I-757；I-760；I-761；I-762；I-763；I-767；I-770；I-771；I-772；I-773；I-775；I-776；I-779；I-780；I-781；I-782；I-783；I-784；I-786；I-787；I-788；I-789；I-790；I-794；I-795；I-796；I-797；I-798；I-802；I-803；I-804；I-805；I-806；I-807；I-808；I-809；I-810；I-811；I-812；I-816；I-817；I-820；I-821；I-822；I-823；I-825；I-831；I-832；I-834
實例 ： 對豆刺盤孢菌 ( 豆類葉斑病 ) 之活體內預防性測試 溶劑：5%按二甲亞碸之體積計 10%   按丙酮之體積計 乳化劑：每毫克活性成分1 µl之Tween® 80
活性成分在二甲亞碸/丙酮/Tween® 80之混合物中可溶且均質化，且隨後在水中稀釋至所需濃度。
藉由噴灑如上文所述製備之活性成份處理豆類之幼株。僅用丙酮/二甲亞碸/Tween® 80之水溶液處理對照植物。
在24小時之後，植株因用豆刺盤孢菌孢子之水性懸浮液噴灑葉片而受到污染。將經污染之菜豆植物在20℃且在100%相對濕度下培育24小時，且隨後在20℃且在90%相對濕度下培育6天。
在接種後7天對測試進行評估。0%意謂對應於對照植物之功效的功效，而100%之功效意謂未觀測到病害。
在此測試中，以下根據本發明之化合物在500 ppm活性成份之濃度下顯示在70%與79%之間的功效： I-005；I-010；I-014；I-030；I-061；I-067；I-099；I-114；I-122；I-140；I-142；I-155；I-165；I-209；I-223；I-238；I-244；I-337；I-339；I-341；I-365；I-376；I-389；I-395；I-408；I-435；I-474；I-478；I-496；I-584；I-590；I-603；I-622；I-658；I-675；I-681；I-685；I-721；I-780；I-782；I-791；I-819；I-828
在此測試中，在500 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-002；I-020；I-065；I-070；I-094；I-145；I-150；I-173；I-185；I-219；I-248；I-263；I-279；I-295；I-303；I-338；I-340；I-364；I-378；I-397；I-401；I-430；I-442；I-443；I-458；I-459；I-460；I-464；I-490；I-500；I-516；I-567；I-596；I-630；I-652；I-656；I-666；I-677；I-712；I-730；I-735；I-740；I-743；I-745；I-759；I-770；I-786；I-788；I-800；I-804；I-817
在此測試中，根據本發明之以下化合物在500 ppm活性成分之濃度下展示90%與100%之間的功效： I-003；I-012；I-013；I-017；I-024；I-026；I-027；I-029；I-034；I-037；I-040；I-044；I-045；I-047；I-048；I-050；I-053；I-054；I-058；I-062；I-063；I-072；I-074；I-077；I-078；I-084；I-085；I-086；I-091；I-092；I-101；I-106；I-108；I-115；I-117；I-124；I-134；I-136；I-138；I-143；I-144；I-146；I-147；I-151；I-152；I-153；I-159；I-160；I-167；I-171；I-175；I-179；I-180；I-184；I-186；I-187；I-188；I-189；I-190；I-194；I-195；I-196；I-197；I-198；I-200；I-204；I-205；I-207；I-213；I-214；I-215；I-217；I-218；I-227；I-229；I-233；I-236；I-237；I-242；I-245；I-247；I-255；I-258；I-261；I-264；I-266；I-267；I-276；I-282；I-283；I-284；I-285；I-288；I-296；I-304；I-311；I-327；I-332；I-336；I-342；I-343；I-344；I-347；I-348；I-352；I-353；I-356；I-357；I-358；I-362；I-367；I-369；I-370；I-373；I-374；I-375；I-380；I-382；I-383；I-384；I-385；I-393；I-396；I-398；I-403；I-409；I-410；I-411；I-415；I-423；I-424；I-428；I-433；I-438；I-445；I-447；I-455；I-457；I-461；I-476；I-477；I-481；I-497；I-502；I-503；I-504；I-506；I-513；I-528；I-533；I-534；I-536；I-543；I-544；I-549；I-555；I-556；I-557；I-561；I-563；I-566；I-574；I-579；I-581；I-582；I-587；I-592；I-594；I-598；I-604；I-606；I-607；I-608；I-610；I-612；I-613；I-614；I-617；I-618；I-619；I-620；I-621；I-624；I-625；I-629；I-631；I-632；I-637；I-638；I-640；I-644；I-645；I-655；I-665；I-686；I-687；I-689；I-690；I-693；I-694；I-695；I-696；I-698；I-699；I-700；I-701；I-702；I-703；I-704；I-706；I-707；I-708；I-709；I-710；I-711；I-713；I-714；I-715；I-716；I-717；I-718；I-719；I-720；I-722；I-723；I-724；I-725；I-726；I-727；I-731；I-732；I-733；I-734；I-736；I-737；I-738；I-742；I-744；I-748；I-749；I-750；I-754；I-756；I-757；I-760；I-761；I-762；I-763；I-764；I-765；I-766；I-773；I-775；I-776；I-779；I-783；I-784；I-787；I-790；I-805；I-806；I-807；I-814；I-816；I-820；I-822；I-823；I-831；I-832；I-834
實例 ： 互生鏈隔孢菌活體外細胞測試 溶劑：DMSO 培養基：14.6 g無水D-葡萄糖(VWR)、7.1 g真菌蛋白腖(Oxoid)、1.4 g顆粒狀酵母提取物(Merck)、QSP 1公升 接種物：孢子懸浮液
將殺真菌劑溶解於DMSO及用於製備所需濃度範圍之溶液中。分析中所用DMSO之最終濃度≤1%。
製備互生鏈隔孢菌之孢子懸浮液且稀釋至所需孢子密度。
評估殺真菌劑抑制液體培養基分析中孢子發芽及菌絲體生長的能力。以所需濃度將化合物添加至具有孢子之培養基。在培育5天之後，藉由菌絲體生長之光譜量測來測定化合物之真菌毒性。藉由比較含有殺真菌劑之孔中之吸光度值與無殺真菌劑之對照孔中之吸光度來測定真菌生長之抑制。
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在70%與79%之間的功效： I-018; I-055; I-088; I-097; I-268; I-289; I-306; I-307; I-308; I-335; I-412; I-437; I-439; I-453; I-705; I-745; I-778; I-792; I-800; I-828
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-016；I-052；I-066；I-068；I-069；I-071；I-087；I-091；I-094；I-098；I-102；I-116；I-118；I-123；I-148；I-164；I-166；I-169；I-192；I-199；I-208；I-216；I-221；I-224；I-232；I-253；I-287；I-299；I-302；I-320；I-326；I-330；I-334；I-354；I-365；I-370；I-376；I-392；I-397；I-414；I-431；I-451；I-473；I-482；I-489；I-490；I-491；I-509；I-518；I-519；I-523；I-525；I-527；I-535；I-540；I-542；I-570；I-585；I-586；I-647；I-660；I-672；I-676；I-727；I-728；I-769；I-814；I-825；I-830
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在90%與100%之間的功效： I-001；I-002；I-003；I-004；I-005；I-007；I-008；I-009；I-010；I-011；I-012；I-013；I-014；I-015；I-017；I-019；I-020；I-021；I-022；I-023；I-024；I-025；I-026；I-027；I-028；I-029；I-030；I-032；I-033；I-034；I-035；I-036；I-037；I-038；I-040；I-041；I-042；I-043；I-044；I-045；I-046；I-047；I-048；I-049；I-050；I-051；I-053；I-054；I-056；I-057；I-058；I-059；I-060；I-061；I-062；I-063；I-064；I-065；I-067；I-070；I-072；I-073；I-074；I-075；I-076；I-077；I-078；I-079；I-080；I-081；I-082；I-083；I-084；I-085；I-086；I-090；I-092；I-093；I-095；I-096；I-099；I-100；I-101；I-103；I-105；I-106；I-107；I-108；I-109；I-110；I-111；I-112；I-113；I-114；I-115；I-117；I-119；I-120；I-121；I-122；I-124；I-125；I-126；I-127；I-128；I-129；I-130；I-131；I-132；I-133；I-134；I-135；I-136；I-137；I-138；I-139；I-140；I-141；I-142；I-143；I-144；I-145；I-146；I-147；I-149；I-151；I-152；I-153；I-154；I-155；I-157；I-158；I-159；I-160；I-161；I-162；I-165；I-167；I-168；I-170；I-171；I-172；I-173；I-174；I-175；I-176；I-178；I-179；I-180；I-181；I-182；I-183；I-184；I-185；I-186；I-187；I-188；I-189；I-190；I-191；I-193；I-194；I-195；I-196；I-197；I-198；I-200；I-201；I-203；I-204；I-205；I-206；I-207；I-209；I-210；I-211；I-212；I-213；I-214；I-215；I-217；I-218；I-219；I-220；I-223；I-225；I-226；I-227；I-228；I-229；I-230；I-231；I-233；I-234；I-235；I-236；I-237；I-238；I-239；I-240；I-241；I-242；I-244；I-245；I-246；I-247；I-248；I-249；I-250；I-251；I-252；I-254；I-255；I-256；I-257；I-258；I-259；I-260；I-261；I-262；I-263；I-264；I-265；I-266；I-267；I-269；I-270；I-271；I-272；I-273；I-274；I-275；I-276；I-277；I-279；I-280；I-281；I-282；I-283；I-284；I-285；I-286；I-288；I-290；I-291；I-292；I-293；I-294；I-295；I-296；I-297；I-298；I-300；I-301；I-303；I-304；I-305；I-309；I-310；I-311；I-312；I-313；I-315；I-316；I-317；I-318；I-319；I-321；I-322；I-323；I-324；I-325；I-327；I-328；I-329；I-331；I-332；I-333；I-336；I-337；I-338；I-339；I-340；I-342；I-343；I-344；I-345；I-346；I-347；I-348；I-349；I-350；I-351；I-352；I-353；I-356；I-357；I-358；I-359；I-360；I-361；I-362；I-363；I-364；I-366；I-367；I-369；I-371；I-372；I-373；I-374；I-375；I-377；I-378；I-379；I-380；I-381；I-382；I-383；I-384；I-385；I-386；I-387；I-388；I-389；I-391；I-393；I-394；I-395；I-396；I-398；I-399；I-400；I-401；I-402；I-403；I-404；I-405；I-406；I-407；I-408；I-409；I-410；I-411；I-413；I-415；I-417；I-418；I-419；I-420；I-421；I-422；I-423；I-424；I-425；I-426；I-427；I-428；I-429；I-430；I-432；I-433；I-434；I-435；I-438；I-440；I-441；I-442；I-443；I-444；I-445；I-446；I-447；I-449；I-450；I-452；I-454；I-455；I-456；I-457；I-458；I-459；I-460；I-461；I-462；I-463；I-464；I-465；I-466；I-467；I-468；I-469；I-470；I-471；I-472；I-474；I-475；I-476；I-477；I-478；I-479；I-480；I-481；I-483；I-484；I-485；I-486；I-487；I-488；I-492；I-493；I-494；I-495；I-496；I-497；I-499；I-500；I-501；I-502；I-503；I-504；I-505；I-506；I-508；I-510；I-511；I-512；I-513；I-514；I-516；I-517；I-520；I-521；I-522；I-524；I-526；I-528；I-530；I-531；I-532；I-533；I-534；I-536；I-537；I-538；I-541；I-543；I-544；I-545；I-546；I-547；I-549；I-550；I-551；I-552；I-553；I-554；I-555；I-556；I-557；I-560；I-561；I-562；I-563；I-564；I-565；I-566；I-567；I-568；I-571；I-572；I-573；I-574；I-575；I-576；I-577；I-578；I-579；I-580；I-581；I-582；I-583；I-584；I-587；I-588；I-589；I-590；I-591；I-592；I-593；I-594；I-595；I-596；I-597；I-598；I-599；I-600；I-601；I-603；I-604；I-605；I-606；I-607；I-608；I-609；I-610；I-611；I-612；I-613；I-614；I-615；I-616；I-617；I-618；I-619；I-620；I-621；I-622；I-623；I-624；I-625；I-626；I-627；I-628；I-629；I-630；I-631；I-632；I-634；I-636；I-637；I-638；I-639；I-640；I-641；I-642；I-643；I-644；I-645；I-646；I-648；I-649；I-650；I-651；I-652；I-653；I-654；I-655；I-656；I-657；I-658；I-659；I-661；I-662；I-664；I-665；I-666；I-673；I-674；I-675；I-677；I-678；I-679；I-680；I-681；I-683；I-684；I-239 686；I-687；I-688；I-692；I-693；I-694；I-695；I-696；I-698；I-699；I-700；I-701；I-702；I-703；I-704；I-706；I-707；I-708；I-709；I-710；I-711；I-712；I-713；I-714；I-715；I-716；I-717；I-718；I-719；I-720；I-721；I-722；I-724；I-725；I-726；I-729；I-730；I-731；I-733；I-735；I-736；I-737；I-738；I-741；I-742；I-743；I-744；I-746；I-747；I-748；I-749；I-750；I-755；I-756；I-757；I-760；I-761；I-762；I-763；I-764；I-765；I-766；I-767；I-768；I-770；I-771；I-773；I-775；I-776；I-777；I-779；I-780；I-781；I-782；I-783；I-784；I-786；I-787；I-788；I-789；I-790；I-791；I-793；I-794；I-795；I-796；I-797；I-798；I-801；I-802；I-803；I-804；I-805；I-806；I-807；I-808；I-809；I-810；I-811；I-812；I-813；I-815；I-816；I-817；I-818；I-820；I-821；I-822；I-823；I-824；I-826；I-827；I-831；I-832；I-834
實例 ： 小麥殼針孢活體外細胞測試 溶劑：DMSO 培養基：14.6 g無水D-葡萄糖(VWR)、7.1 g細菌蛋白腖(Oxoid)、1.4 g顆粒狀酵母提取物(Merck)、QSP 1公升 接種物：孢子懸浮液
將殺真菌劑溶解於DMSO及用於製備所需濃度範圍之溶液中。分析中所用DMSO之最終濃度≤ 1%。
製備小麥殼針孢之孢子懸浮液且稀釋至所需孢子密度。
評估殺真菌劑抑制液體培養基分析中孢子發芽及菌絲體生長的能力。以所需濃度將化合物添加至具有孢子之培養基。在培養7天之後，藉由菌絲體生長之光譜量測來測定化合物之真菌毒性。藉由比較含有殺真菌劑之孔中之吸光度值與無殺真菌劑之對照孔中之吸光度來測定真菌生長之抑制。
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在70%與79%之間的功效： I-085; I-194; I-203; I-212; I-344; I-380; I-407; I-478; I-680; I-703; I-707; I-709; I-710; I-712; I-735; I-755; I-790; I-796
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-003; I-106; I-142; I-172; I-179; I-191; I-198; I-230; I-304; I-369; I-379; I-385; I-398; I-399; I-415; I-422; I-430; I-445; I-640; I-679; I-742; I-744
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在90%與100%之間的功效： I-012；I-016；I-030；I-032；I-040；I-054；I-055；I-070；I-077；I-084；I-092；I-124；I-136；I-173；I-176；I-186；I-190；I-197；I-207；I-208；I-218；I-231；I-245；I-257；I-265；I-285；I-293；I-353；I-358；I-359；I-372；I-374；I-383；I-389；I-405；I-411；I-455；I-458；I-497；I-499；I-506；I-508；I-524；I-550；I-616；I-725；I-726；I-763；I-805；I-807；I-808；I-822
實例 ： 豆刺盤孢菌活體外細胞測試 溶劑：DMSO 培養基：14.6 g無水D-葡萄糖(VWR)、7.1 g真菌蛋白腖(Oxoid)、1.4 g顆粒狀酵母提取物(Merck)、QSP 1公升 接種物：孢子懸浮液
將殺真菌劑溶解於DMSO及用於製備所需濃度範圍之溶液中。分析中所用DMSO之最終濃度≤ 1%。
製備菜豆炭疽病菌 之孢子懸浮液且稀釋至所需孢子密度。
評估殺真菌劑抑制液體培養基分析中孢子發芽及菌絲體生長的能力。以所需濃度將化合物添加至具有孢子之培養基。在培養6天之後，藉由菌絲體生長之光譜量測來測定化合物之真菌毒性。藉由比較含有殺真菌劑之孔中之吸光度值與無殺真菌劑之對照孔中之吸光度來測定真菌生長之抑制。
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在70%與79%之間的功效： I-039；I-051；I-052；I-068；I-076；I-089；I-123；I-156；I-168；I-170；I-280；I-287；I-299；I-305；I-306；I-314；I-323；I-325；I-329；I-346；I-351；I-368；I-381；I-397；I-412；I-413；I-436；I-437；I-451；I-452；I-525；I-541；I-564；I-585；I-691；I-732；I-736；I-793；I-800；I-813；I-829
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在80%與89%之間的功效： I-004；I-006；I-066；I-071；I-095；I-098；I-100；I-112；I-116；I-119；I-131；I-132；I-138；I-150；I-164；I-166；I-179；I-180；I-199；I-213；I-224；I-227；I-231；I-232；I-246；I-271；I-291；I-302；I-310；I-313；I-326；I-334；I-335；I-405；I-414；I-425；I-429；I-431；I-432；I-462；I-465；I-466；I-475；I-479；I-482；I-484；I-487；I-491；I-492；I-493；I-495；I-518；I-521；I-527；I-535；I-537；I-540；I-542；I-559；I-560；I-562；I-568；I-576；I-583；I-586；I-601；I-609；I-628；I-647；I-660；I-672；I-689；I-727；I-728；I-792；I-795；I-797；I-809；I-812；I-825
在此測試中，在20 ppm活性成分之濃度下以下根據本發明之化合物顯示在90%與100%之間的功效： I-001；I-002；I-003；I-005；I-008；I-009；I-010；I-011；I-012；I-013；I-014；I-017；I-020；I-021；I-022；I-023；I-024；I-025；I-026；I-027；I-028；I-029；I-030；I-032；I-033；I-034；I-035；I-036；I-037；I-038；I-041；I-042；I-043；I-044；I-045；I-046；I-047；I-048；I-049；I-050；I-053；I-054；I-056；I-057；I-058；I-060；I-061；I-062；I-063；I-064；I-065；I-069；I-070；I-072；I-074；I-077；I-078；I-080；I-081；I-082；I-083；I-084；I-085；I-086；I-090；I-091；I-092；I-093；I-094；I-096；I-101；I-103；I-104；I-105；I-106；I-107；I-108；I-111；I-114；I-115；I-117；I-118；I-120；I-121；I-122；I-124；I-126；I-127；I-128；I-129；I-130；I-133；I-134；I-135；I-136；I-137；I-139；I-140；I-141；I-142；I-143；I-144；I-145；I-146；I-147；I-149；I-151；I-152；I-153；I-154；I-155；I-157；I-158；I-159；I-160；I-161；I-162；I-165；I-167；I-169；I-171；I-172；I-173；I-174；I-175；I-176；I-178；I-181；I-182；I-183；I-184；I-185；I-186；I-187；I-188；I-189；I-190；I-191；I-192；I-193；I-194；I-195；I-196；I-197；I-198；I-200；I-201；I-202；I-203；I-204；I-205；I-206；I-207；I-209；I-210；I-211；I-212；I-214；I-215；I-216；I-217；I-218；I-219；I-220；I-221；I-222；I-223；I-225；I-226；I-228；I-229；I-230；I-233；I-234；I-235；I-236；I-237；I-238；I-239；I-240；I-241；I-242；I-243；I-244；I-245；I-247；I-248；I-249；I-251；I-252；I-254；I-255；I-256；I-257；I-258；I-259；I-260；I-261；I-262；I-263；I-264；I-265；I-266；I-267；I-269；I-270；I-272；I-273；I-274；I-275；I-276；I-277；I-279；I-281；I-282；I-283；I-284；I-285；I-288；I-290；I-292；I-293；I-294；I-295；I-296；I-298；I-300；I-301；I-303；I-304；I-308；I-309；I-311；I-312；I-315；I-316；I-317；I-318；I-319；I-320；I-321；I-322；I-324；I-327；I-330；I-331；I-332；I-333；I-336；I-337；I-338；I-339；I-340；I-342；I-343；I-345；I-347；I-350；I-352；I-353；I-356；I-357；I-358；I-359；I-360；I-361；I-362；I-363；I-364；I-365；I-366；I-367；I-369；I-370；I-372；I-373；I-374；I-377；I-378；I-379；I-380；I-382；I-383；I-384；I-385；I-386；I-387；I-388；I-389；I-390；I-391；I-392；I-393；I-394；I-395；I-396；I-398；I-399；I-400；I-401；I-402；I-403；I-404；I-406；I-407；I-408；I-409；I-410；I-415；I-418；I-420；I-421；I-422；I-423；I-424；I-426；I-428；I-430；I-433；I-434；I-438；I-440；I-441；I-442；I-443；I-444；I-445；I-446；I-447；I-449；I-450；I-453；I-454；I-455；I-456；I-457；I-458；I-461；I-463；I-464；I-467；I-468；I-469；I-470；I-471；I-472；I-474；I-476；I-477；I-480；I-481；I-483；I-485；I-486；I-488；I-489；I-490；I-497；I-499；I-500；I-502；I-503；I-504；I-508；I-510；I-511；I-513；I-514；I-517；I-520；I-524；I-528；I-530；I-531；I-533；I-536；I-543；I-544；I-545；I-546；I-547；I-550；I-551；I-552；I-553；I-554；I-555；I-556；I-557；I-561；I-563；I-565；I-566；I-567；I-570；I-571；I-572；I-574；I-575；I-577；I-578；I-579；I-580；I-581；I-582；I-587；I-588；I-589；I-590；I-591；I-592；I-593；I-594；I-595；I-597；I-598；I-599；I-600；I-604；I-605；I-606；I-607；I-608；I-610；I-611；I-612；I-613；I-614；I-615；I-616；I-617；I-618；I-619；I-620；I-621；I-622；I-624；I-625；I-626；I-627；I-629；I-630；I-631；I-632；I-634；I-636；I-637；I-638；I-639；I-640；I-642；I-643；I-644；I-645；I-648；I-649；I-650；I-651；I-652；I-653；I-654；I-655；I-656；I-657；I-658；I-659；I-661；I-662；I-664；I-665；I-666；I-673；I-674；I-675；I-676；I-677；I-678；I-679；I-680；I-681；I-683；I-684；I-686；I-687；I-692；I-693；I-694；I-695；I-696；I-697；I-698；I-699；I-700；I-701；I-702；I-703；I-704；I-706；I-707；I-708；I-709；I-710；I-711；I-712；I-713；I-714；I-715；I-716；I-717；I-718；I-719；I-720；I-721；I-722；I-723；I-724；I-725；I-726；I-730；I-731；I-733；I-734；I-735；I-737；I-738；I-739；I-740；I-741；I-742；I-743；I-744；I-745；I-746；I-747；I-748；I-749；I-750；I-754；I-755；I-756；I-757；I-760；I-761；I-762；I-763；I-764；I-765；I-766；I-767；I-768；I-769；I-770；I-771；I-772；I-773；I-775；I-776；I-777；I-778；I-779；I-780；I-781；I-782；I-783；I-784；I-786；I-787；I-788；I-789；I-790；I-791；I-794；I-796；I-798；I-801；I-802；I-803；I-804；I-805；I-806；I-807；I-808；I-810；I-811；I-814；I-815；I-816；I-817；I-818；I-819；I-820；I-821；I-822；I-823；I-824；I-826；I-827；I-828；I-830；I-831；I-832；I-834
Figure 108143210-A0101-11-0001-1

Claims (16)

  1. 一種式(I)之化合物，
    Figure 03_image001
    其中T 為O或S；n 為0或1；m 為0或1； 限制條件為當n 為1時，m 為1；R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，其中Ra1 選自由以下組成之群：C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基，且Ra2 選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C2 -C6 烯基；R2 及R3 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R2 及R3 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；R4 及R5 獨立地選自由以下組成之群：氫、鹵素、氰基、羥基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷氧羰基及C3 -C8 環烷基，或R4 及R5 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環；或R2 及R4 與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環，且R3 及R5 獨立地為氫或鹵素；或R2 與R4 一起形成共價鍵且R3 及R5 獨立地為氫或C1 -C6 烷基；R6 係選自由以下組成之群：非芳族C3 -C12 碳環、芳族C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、非芳族C3 -C12 碳環基氧基、芳族C6 -C14 碳環基氧基、芳族5員至14員雜環基氧基、非芳族3員至14員雜環基氧基、經非芳族C3 -C12 碳環取代之C1 -C3 烷氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基、經非芳族3員至14員雜環取代之C1 -C3 烷氧基、經芳族5員至14員雜環取代之C1 -C3 烷氧基、經非芳族C3 -C12 碳環取代之C1 -C3 鹵烷氧基、經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基、經非芳族3員至14員雜環取代之C1 -C3 鹵烷氧基及經芳族5員至14員雜環取代之C1 -C3 鹵烷氧基，其中R6 取代基之環狀或環狀部分可經一或多個可相同或不同之R6S 取代基取代，R6S 係選自由以下組成之群：鹵素、氰基、異氰基、硝基、羥基、巰基、五氟硫基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C3 -C8 環烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基磺醯基、C3 -C8 環烷基、C3 -C8 環烷基氧基、C3 -C8 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Rc )2 、-C(=O)Rd 、-C(=O)(ORd )、-C(=O)N(Rd )2 、-S(=O)2 N(Rd )2 、-O-Si(C1 -C6 烷基)3 及-Si(C1 -C6 烷基)3 ，或兩個R6S 取代基可與其所連接之碳原子一起形成C3 -C8 環烷基， 其中Rc 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C3 -C8 環烷基， 其中Rd 獨立地選自由以下組成之群：氫、C1 -C6 烷基及C1 -C6 鹵烷基， 其中脂族R6S 、Rc 及Rd 取代基可經一或多個獨立地選自由以下組成之群的取代基取代：氰基、羥基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、C3 -C8 環烷基、C3 -C8 鹵環烷基及非芳族3員至7員單環雜環， 其中R6S 及環狀Rc 取代基之環狀或環狀部分可經一或多個獨立地選自由以下組成之群的取代基取代：鹵素、氰基、硝基、羥基、甲醯基、羧基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C3 -C8 環烷基及C3 -C8 鹵環烷基，及/或R6S 取代基之環狀或環狀部分可經兩個取代基取代，其中兩個取代基與其所連接之碳原子一起形成C3 -C8 環烷基；R7 係選自由以下組成之群：氫、鹵素、氰基、異氰基、羥基、巰基、硝基、胺基、甲醯基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C3 -C8 環烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基磺醯基、C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、-N(Re )2 、-C(=NRf )Rf 、-NRg C(=O)Rg 、-C(=O)(ORg )、-C(=O)N(Rg )2 、-S(=O)2 N(Rg )2 及-S(=O)(=NRg )Rg ， 其中Re 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環， 其中Rf 獨立地選自由以下組成之群：羥基、胺基、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 烷胺基及二(C1 -C6 烷基)胺基， 其中Rg 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基及C3 -C8 環烷基， 其中脂族R7 、Re 、Rf 及Rg 取代基可經一或多個可相同或不同之R7Sa 取代基取代， 其中R7 之環狀或環狀部分、環狀Re 及環狀Rg 取代基可經一或多個可相同或不同之R7Sc 取代基取代，R7Sa 係選自由以下組成之群：氰基、羥基、羧基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C1 -C6 烷氧羰基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、芳族C6 -C14 碳環及非芳族3員至7員單環雜環，R7Sc 係選自由以下組成之群：鹵素、氰基、硝基、羥基、甲醯基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C3 -C8 環烷基、C3 -C8 鹵環烷基、-O-Si(C1 -C6 烷基)3 及非芳族3至7員單環雜環，或兩個R7Sc 取代基與其所連接之碳原子一起形成C3 -C8 環烷基；R8 係選自由以下組成之群：氫、鹵素、氰基、異氰基、胺基、硝基、羥基、巰基、羧基、C1 -C6 烷氧羰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基、C3 -C6 環烯基、芳族C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、非芳族3員至14員雜環基氧基、芳族5員至14員雜環基氧基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、-N(Rh )2 、-SRi 、-S(=O)Ri 及-S(=O)2 Ri ， 其中Rh 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員至14員雜環及非芳族3員至7員單環雜環， 其中Ri 選自由以下組成之群：C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C3 -C8 環烷基、C3 -C8 鹵環烷基、芳族C6 -C14 碳環、芳族5員至14員雜環及非芳族3員至7員單環雜環， 其中脂族R8 、Rh 及Ri 取代基可經一或多個可相同或不同之R8Sa 取代基取代， 其中R8 、環狀Rh 及環狀Ri 取代基之環狀或環狀部分可經一或多個可相同或不同之R8Sc 取代基取代，R8Sa 係選自由以下組成之群：氰基、胺基、硝基、羥基、甲醯基、羧基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、非芳族3員至7員單環雜環及-N(Ra ' )2 ，其中Ra ' 獨立地選自由以下組成之群：氫、甲醯基、C1 -C6 烷基、C1 -C6 鹵烷基、C3 -C8 環烷基及C1 -C6 烷基羰基，其中該非芳族3員至7員單環雜環R8Sa 可經一或多個可相同或不同之C1 -C6 烷基取代基取代，R8Sc 係選自由以下組成之群：鹵素、氰基、胺基、硝基、羥基、甲醯基、羧基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、C3 -C8 鹵環烷基、-O-Si(C1 -C6 烷基)3 及非芳族3員至7員單環雜環，其可經一或多個可相同或不同之C1 -C6 烷基取代基取代，或兩個R8Sc 取代基與其所連接之碳原子一起形成C3 -C8 環烷基或非芳族3員至7員單環雜環，其中該非芳族3員至7員單環雜環可經一或多個可相同或不同之C1 -C6 烷基取代基取代；Q 係選自由以下組成之群：芳族C6 -C14 碳環、非芳族C3 -C12 碳環、非芳族3員至14員雜環及芳族5員至14員雜環，其中該等碳環或雜環基中之任一者可經一或多個可相同或不同之QS 取代基取代，QS 係選自由以下組成之群：鹵素、氰基、異氰基、硝基、羥基、巰基、甲醯基、羧基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷基羰基、C1 -C6 鹵烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C2 -C6 烯基、C2 -C6 鹵烯基、C2 -C6 炔基、C2 -C6 鹵炔基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 鹵烷基亞磺醯基、C1 -C6 烷基磺醯基、C1 -C6 鹵烷基磺醯基、C3 -C8 環烷基、C3 -C8 環烷基氧基、C3 -C6 環烯基、非芳族3員至7員單環雜環、芳族5員至14員雜環、-O-Si(C1 -C6 烷基)3 、-Si(C1 -C6 烷基)3 、-O-C(=O)Rj 、-NRj C(=O)Rj 、-C(=O)N(Rj )2 、-C(=S)Rj 、-C(=S)N(Rj )2 、-C(=NRj )Rj 及-C(=NORj )Rj 及-N(Rk )2 其中Rj 獨立地選自由以下組成之群：氫、C1 -C6 烷基、C1 -C6 鹵烷基及C1 -C6 烷氧基， 其中Rk 獨立地選自由以下組成之群：氫、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 鹵烯基及C3 -C8 環烷基， 其中脂族QS 、Rj 及Rk 取代基可經一或多個獨立地選自由以下組成之群的取代基取代：氰基、胺基、硝基、羥基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C3 -C8 環烷基、C3 -C8 鹵環烷基、-Si(C1 -C6 烷基)3 及非芳族3員至7員單環雜環， 其中QS 及環狀Rk 取代基之環狀或環狀部分可經一或多個獨立地選自由以下組成之群的RQs 取代基取代：鹵素、氰基、胺基、硝基、羥基、甲醯基、羧基、側氧基、亞甲基、鹵亞甲基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧羰基、C1 -C6 鹵烷氧羰基、C3 -C8 環烷基、C3 -C8 鹵環烷基、C2 -C6 烯基及非芳族3員至7員單環雜環，其中環狀RQs 取代基可經兩個取代基取代，其中該兩個取代基與其所連接之碳原子一起形成C3 -C8 環烷基， 以及其鹽、N-氧化物及溶劑合物； 其限制條件為式(I)之化合物不為： (a) 3-(1H -苯并三唑-1-基氧基)-N-(4-第三丁基苯基)-6-氯嗒𠯤-4-甲醯胺([561297-99-2])； (b) 3-(環戊氧基)-6-(4-氟苯氧基)-N-{[(3R)-1-異丙基哌啶-3-基]甲基}嗒𠯤-4-甲醯胺([1336909-91-1])； (c) 6-(4-氟苯氧基)-N-{[(3R)-1-異丙基哌啶-3-基]甲基}-3-(四氫-2H-哌喃-4-基氧基)嗒𠯤-4-甲醯胺([1336909-90-0])； (d) 6-氯-N-{[(3R)-1-異丙基哌啶-3-基]甲基}-3-(四氫-2H-哌喃-4-基氧基)嗒𠯤-4-甲醯胺([1336910-48-5])； (e) 6-氯-3-(環戊氧基)-N-{[(3R)-1-異丙基哌啶-3-基]甲基}嗒𠯤-4-甲醯胺([1336910-49-6])； (f) 3-(1H-苯并三唑-1-基氧基)-6-氯-N-(環己基甲基)嗒𠯤-4-甲醯胺([1202404-84-9)]。
  2. 如請求項1之式(I)之化合物，其中Q 係選自由以下組成之群：芳族C6 -C14 碳環、包含與C3 -C8 環烷基稠合之芳基的非芳族C7 -C12 雙環系統、包含與C3 -C8 環烯基稠合之芳基的非芳族C7 -C12 雙環系統、包含與芳基稠合之4至6員單環非芳族雜環的非芳族6員至14員雙環雜環、包含與單環C3 -C8 環烷基稠合之5員或6員單環雜芳基的非芳族6員至14員雙環雜環、芳族5員或6員單環雜環、包含與芳基稠合之芳族5員或6員單環雜環的芳族9員或10員雙環雜環、及包含兩個稠合的芳族5員或6員單環雜環的9員或10員芳族雙環雜環，其中該等環狀基團中之每一者可經可相同或不同之如請求項1所敍述之一或多個QS 取代基取代。
  3. 如請求項1或2之式(I)之化合物，其中Q 係選自由以下組成之群：苯基、萘基、雙環[4.2.0]辛-1(6),2,4-三烯基、苯并二氧雜環戊烯基、2,3-二氫苯并呋喃基、吡啶基、噻吩基及吲哚基，其中該等苯基、萘基、雙環[4.2.0]辛-1(6),2,4-三烯基、苯并二氧雜環戊烯基、2,3-二氫苯并呋喃基、吡啶基、噻吩基及吲哚基可經可相同或不同之如請求項1中所敍述之一或多個QS 取代基取代。
  4. 如請求項1或2之式(I)之化合物，其中QS 係選自由以下組成之群：鹵素、氰基、硝基、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C1 -C6 烷氧基-C1 -C6 烷基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、非芳族3員至7員單環雜環及-N(Rk )2 ，其中Rk 為氫。
  5. 如請求項1或2之式(I)之化合物，其中R6 係選自由以下組成之群：芳族C6 -C14 碳環、非芳族多環C7 -C12 碳環、非芳族多環6員至14員雜環、芳族5員至14員雜環、芳族C6 -C14 碳環基氧基、經芳族C6 -C14 碳環取代之C1 -C3 烷氧基及經芳族C6 -C14 碳環取代之C1 -C3 鹵烷氧基，其中R6 取代基之環狀或環狀部分可經如請求項1中所敍述之可相同或不同之一或多個R6S 取代基取代。
  6. 如請求項1或2之式(I)之化合物，其中R6 係選自由以下組成之群：苯基、二氫茚基、1,2,3,4-四氫萘基、螺[環丙烷-1,2'-二氫茚]-1-基、萘基、2,3-二氫苯并呋喃基、吲哚啉基、1,3-苯并二氧雜環戊烯基、𠳭烷基、異𠳭烷基、硫代𠳭烷基、2,3-二氫-1,4-苯并二氧雜環己烯基、5,6,7,8-四氫喹啉基、4,5,6,7-四氫苯并噻吩基、呋喃基、噻吩基、吡啶基、嘧啶基、吲哚基、苯并呋喃基、苯并噁唑基、喹啉基、異喹啉基、咪唑并[1,2-a]吡啶基、苯氧基、苯甲氧基及-OCF2 -苯基，其中R6 取代基之環狀或環狀部分可經可相同或不同之如請求項1中所敍述之一或多個R6S 取代基取代。
  7. 如請求項1或2之式(I)之化合物，其中R6S 係選自由以下組成之群：鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、芳族C6 -C14 碳環、芳族5員或6員單環雜環及非芳族3員至7員單環雜環，其中環狀R6S 取代基可經一或多個獨立地選自由以下組成之群的取代基取代：鹵素、C1 -C6 烷基、C1 -C6 鹵烷基及C1 -C6 烷氧羰基。
  8. 如請求項1或2之式(I)之化合物，其中R1 係選自由以下組成之群：氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、C1 -C6 烷氧基-C1 -C6 烷基及C(=O)(ORa1 )，其中Ra1 為C1 -C6 烷基或C2 -C6 烯基。
  9. 如請求項1或2之式(I)之化合物，其中R7 係選自由以下組成之群：氫、鹵素、氰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 羥基烷基、C1 -C6 烷基羰基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 炔基、C1 -C6 烷基硫基、C1 -C6 烷基亞磺醯基、C3 -C8 環烷基、芳族5員或6員單環雜環、非芳族3員至7員單環雜環、-N(Re )2 、-C(=NRf )Rf 及-C(=O)N(Rg )2 ，其中Re 、Rf 及Rg 如請求項1中所敍述。
  10. 如請求項1或2之式(I)之化合物，其中R8 係選自由以下組成之群：氫、鹵素、羥基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C2 -C6 烯基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C1 -C6 烷基亞磺醯基、C1 -C6 烷基磺醯基、C3 -C8 環烷基、芳族C6 -C14 碳環、非芳族3員至14員雜環、芳族5員至14員雜環、C3 -C8 環烷基氧基、非芳族3員至14員雜環基氧基及-N(Rh )2 ，其中Rh 如請求項1中所敍述。
  11. 一種組合物，其包含至少一種如請求項1至10中任一項之式(I)之化合物及至少一種農業上適合之助劑。
  12. 一種用於控制植物病原性真菌之方法，其包含以下步驟：將至少一種如請求項1至10中任一項之式(I)之化合物或如請求項11之組合物施加至植物、植物部分、種子、果實或施加至植物生長之土壤中。
  13. 一種用於製備式(I)之化合物之方法
    Figure 03_image094
    其中R1 為氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，T 為O及Ra1 、Ra2 、R2 、R3 、R4 、R5 、R6 、R7 、R8 、n 、m 及Q 為如請求項1中所敍述， 其包含以下步驟：使式(1)之化合物
    Figure 03_image096
    其中U1 為羥基、鹵素或C1 -C6 烷氧基，且R7 、R8 及Q 如請求項1中所敍述， 與式(2)之胺反應
    Figure 03_image098
    其中R1 為氫、羥基、氰基、C1 -C6 烷基、C1 -C6 烷氧基、-C(=O)Ra1 、-C(=O)(ORa1 )、-S(=O)Ra1 、-S(=O)2 Ra1 、-C(=O)N(Ra2 )2 及S(=O)2 N(Ra2 )2 ，其中Ra1 、Ra2 、R2 、R3 、R4 、R5 、R6 、n 及m 如請求項1中所敍述。
  14. 一種用於製備式(I)之化合物之方法
    Figure 03_image100
    其中R1 為氫、羥基、C1 -C6 烷基或C1 -C6 烷氧基，T 為O，R8 為氫或C1 -C6 烷基，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如請求項1中所敍述且R2 、R3 、R4 、R5 、R6 、n 、m 及Q 如請求項1中所敍述， 其包含以下步驟：使式(3)之化合物
    Figure 03_image102
    其中G 為鹵素，R1 為氫、羥基、C1 -C6 烷基或C1 -C6 烷氧基，R8 為氫或C1 -C6 烷基，R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如請求項1中所敍述且R2 、R3 、R4 、R5 、R6 、n 及m 如請求項1中所敍述， 與式(4)之化合物
    Figure 03_image104
    其中Q 如請求項1中所敍述， 在鹼存在下反應。
  15. 一種式(1)之化合物，
    Figure 03_image106
    其中Q如請求項1中所敍述；U1 為羥基、鹵素或C1 -C6 烷氧基；R7 、R8 如請求項1中所敍述且不同時表示氫、C1 -C6 烷基及芳族C6 -C14 碳環； 其限制條件為式(1)之化合物不為： 6-氯-3-(2,4-二氟苯氧基)嗒𠯤-4-甲酸甲酯 1007571-73-4 6-氯-3-[(8-甲醯基-4-甲基-2-側氧基-2H-苯并哌喃-7-基)氧基]嗒𠯤-4-甲酸 953070-74-1 6-氯-3-[(3-甲醯基-7-甲基喹啉-2-基)氧基]嗒𠯤-4-甲酸 953070-59-2 6-氯-3-{[4-甲醯基-5-(羥基甲基)-2-甲基吡啶-3-基]氧基}嗒𠯤-4-甲酸 953070-45-6 6-氯-3-[(1-甲醯基-2-萘基)氧基]嗒𠯤-4-甲酸 953070-36-5 6-氯-3-(2-甲醯基-5-甲氧基苯氧基)嗒𠯤-4-甲酸 953070-24-1 3-苯氧基-6-苯基嗒𠯤-4-甲酸乙酯 338752-99-1。
  16. 一種式(3)之化合物，
    Figure 03_image108
    其中G 為鹵素；n =1且m =1；R1 為氫；R2 、R3 為氫；R4 及R5 為氫或氟；R6 係選自由以下組成之群：非芳族多環C7 -C12 碳環、芳族C6 -C14 碳環及非芳族6員至14員多環雜環；R7 係選自由以下組成之群：氫、鹵素、羥基、巰基、C1 -C6 烷基、C1 -C6 鹵烷基、C1 -C6 烷氧基、C1 -C6 鹵烷氧基、C2 -C6 烯氧基、C2 -C6 鹵烯氧基、C2 -C6 炔基氧基、C2 -C6 鹵炔基氧基、C1 -C6 烷基硫基、C1 -C6 鹵烷基硫基、C3 -C8 環烷基、C3 -C6 環烯基、C3 -C8 環烷基氧基、芳族C6 -C14 碳環基氧基、芳族5員或6員單環雜環基氧基、非芳族3員至7員單環雜環基氧基及-N(Re )2 ，其中Re 如請求項1中所敍述且其中R7 及Re 可如請求項1中所敍述經取代；R8 為氫或C1 -C6 烷基； 其限制條件為式(3)之化合物不為： 3,6-二氯-N-[2-(3,5-二氟苯基)乙基]嗒𠯤-4-甲醯胺 1963486-79-4 3,6-二氯-N-[2-(3-甲基苯基)乙基]嗒𠯤-4-甲醯胺 1963267-34-6 3,6-二氯-N-[2-(3-氯苯基)乙基]嗒𠯤-4-甲醯胺 1961466-79-4 3,6-二氯-N-[2-(4-氟-2-甲基苯基)乙基]嗒𠯤-4-甲醯胺 1958752-63-0 3,6-二氯-N-[2-(3-甲氧苯基)乙基]嗒𠯤-4-甲醯胺 1939713-84-4 3,6-二氯-N-[2-(2-甲基苯基)乙基]嗒𠯤-4-甲醯胺 1931068-89-1 3,6-二氯-N-[2-(4-羥基苯基)乙基]嗒𠯤-4-甲醯胺 1930978-66-7 3,6-二氯-N-[2-(3-氟苯基)乙基]嗒𠯤-4-甲醯胺 1930464-33-7 3,6-二氯-N-[2-(2-甲氧苯基)乙基]嗒𠯤-4-甲醯胺 1926106-33-3 3,6-二氯-N-[2-(4-甲氧苯基)乙基]嗒𠯤-4-甲醯胺 1917672-49-1 3,6-二氯-N-[2-(4-氟苯基)乙基]嗒𠯤-4-甲醯胺 1916146-17-2 3,6-二氯-N-[2-(2,4-二氯苯基)乙基]嗒𠯤-4-甲醯胺 1912316-22-3 3,6-二氯-N-[2-(2-氟苯基)乙基]嗒𠯤-4-甲醯胺 1911438-43-1 3,6-二氯-N-(2-苯基乙基)嗒𠯤-4-甲醯胺 199478-02-9。
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