TW202027754A - 神經活性類固醇及其使用方法 - Google Patents

神經活性類固醇及其使用方法 Download PDF

Info

Publication number
TW202027754A
TW202027754A TW108137951A TW108137951A TW202027754A TW 202027754 A TW202027754 A TW 202027754A TW 108137951 A TW108137951 A TW 108137951A TW 108137951 A TW108137951 A TW 108137951A TW 202027754 A TW202027754 A TW 202027754A
Authority
TW
Taiwan
Prior art keywords
substituted
unsubstituted
group
compound
alkyl
Prior art date
Application number
TW108137951A
Other languages
English (en)
Chinese (zh)
Inventor
法藍西司科 G 薩突羅
佩拉杜 馬利亞 耶穌 巴蘭可
馬歇爾 理 莫寧斯塔爾
柏伊德 L 哈里森
Original Assignee
美商賽吉醫療公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商賽吉醫療公司 filed Critical 美商賽吉醫療公司
Publication of TW202027754A publication Critical patent/TW202027754A/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/009Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0007Androstane derivatives not substituted in position 17
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J13/00Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
TW108137951A 2018-10-19 2019-10-21 神經活性類固醇及其使用方法 TW202027754A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862748016P 2018-10-19 2018-10-19
US62/748,016 2018-10-19

Publications (1)

Publication Number Publication Date
TW202027754A true TW202027754A (zh) 2020-08-01

Family

ID=68468867

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108137951A TW202027754A (zh) 2018-10-19 2019-10-21 神經活性類固醇及其使用方法

Country Status (13)

Country Link
US (2) US20210363175A1 (https=)
EP (2) EP3867261B1 (https=)
JP (2) JP7534291B2 (https=)
CN (1) CN113227114B (https=)
AR (1) AR116771A1 (https=)
AU (2) AU2019359899B2 (https=)
BR (1) BR112021007401A2 (https=)
CA (1) CA3116892A1 (https=)
DK (1) DK3867261T3 (https=)
ES (1) ES3039267T3 (https=)
MX (2) MX2021004452A (https=)
TW (1) TW202027754A (https=)
WO (1) WO2020082065A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2806877B2 (en) 2012-01-23 2025-01-29 Sage Therapeutics, Inc. Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
MA51046A (fr) 2017-12-08 2021-03-17 Sage Therapeutics Inc Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953429A (en) * 1970-12-17 1976-04-27 Glaxo Laboratories Limited Anaesthetic steroids of the androstance and pregnane series
DE2526373C2 (de) * 1975-06-11 1983-11-10 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von Δ↑9↑↑(↑↑1↑↑1↑↑)↑-5α-20-Ketosteroiden
EP0221705A1 (en) * 1985-10-23 1987-05-13 The Upjohn Company Tetrahydro angiostatic steroids
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
WO1998005337A1 (en) * 1996-08-01 1998-02-12 Cocensys, Inc. Use of gaba and nmda receptor ligands for the treatment of migraine headache
CN117024501A (zh) * 2014-10-16 2023-11-10 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation

Also Published As

Publication number Publication date
EP4606812A3 (en) 2025-10-15
WO2020082065A1 (en) 2020-04-23
EP3867261B1 (en) 2025-04-30
JP2024096347A (ja) 2024-07-12
EP3867261A1 (en) 2021-08-25
US20210363175A1 (en) 2021-11-25
EP4606812A2 (en) 2025-08-27
US20250136638A1 (en) 2025-05-01
CN113227114B (zh) 2026-01-27
DK3867261T3 (da) 2025-08-18
AR116771A1 (es) 2021-06-09
ES3039267T3 (en) 2025-10-20
AU2024220209A1 (en) 2024-10-17
AU2019359899B2 (en) 2024-07-04
CN113227114A (zh) 2021-08-06
AU2019359899A1 (en) 2021-05-20
MX2021004452A (es) 2021-08-11
MX2024014845A (es) 2025-01-09
JP2022505146A (ja) 2022-01-14
JP7534291B2 (ja) 2024-08-14
CA3116892A1 (en) 2020-04-23
BR112021007401A2 (pt) 2021-08-03

Similar Documents

Publication Publication Date Title
US11147877B2 (en) Compositions and methods for treating CNS disorders
JP7065825B2 (ja) C7、c12、およびc16置換神経刺激性ステロイドおよびそれらの使用方法
JP7049313B2 (ja) C17、c20、およびc21置換神経刺激性ステロイドおよびそれらの使用方法
JP6875996B2 (ja) 神経刺激性ステロイド、組成物、およびその使用
TWI869654B (zh) 用於治療中樞神經系統(cns)病症之組合物及方法
TW202027754A (zh) 神經活性類固醇及其使用方法
JP2020183434A (ja) Cns障害を処置するための組成物および方法
CN113166193B (zh) 用于治疗cns病症的在位置10处被环状基团取代的神经活性类固醇
TW202038967A (zh) 神經活性類固醇及其組合物
TW202114695A (zh) 用於治療cns病症之組合物及方法
TW202114700A (zh) 用於治療cns病症之組合物及方法
HK40130819A (en) 9(11)-unsaturated neuroactive steroids and their methods of use
RU2828261C2 (ru) С17-, с20- и с21-замещенные нейроактивные стероиды и способы их применения
HK40059498B (en) 9(11)-unsaturated neuroactive steroids and their methods of use
HK40059498A (en) 9(11)-unsaturated neuroactive steroids and their methods of use
BR122024013785A2 (pt) Compostos esteroides neuroativos, composição farmacêutica e seus usos
HK1242201B (en) Compositions and methods for treating cns disorders