BR112021007401A2 - esteroides neuroativos insaturados 9(11) e seus métodos de uso - Google Patents

esteroides neuroativos insaturados 9(11) e seus métodos de uso Download PDF

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Publication number
BR112021007401A2
BR112021007401A2 BR112021007401-5A BR112021007401A BR112021007401A2 BR 112021007401 A2 BR112021007401 A2 BR 112021007401A2 BR 112021007401 A BR112021007401 A BR 112021007401A BR 112021007401 A2 BR112021007401 A2 BR 112021007401A2
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BR
Brazil
Prior art keywords
substituted
unsubstituted
compound
alkyl
formula
Prior art date
Application number
BR112021007401-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Francesco G. Salituro
Maria Jesus Blanc-Pillado
Marshall Lee Morningstar
Boyd L. Harrison
Original Assignee
Sage Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics, Inc. filed Critical Sage Therapeutics, Inc.
Publication of BR112021007401A2 publication Critical patent/BR112021007401A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/009Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0007Androstane derivatives not substituted in position 17
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J13/00Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
BR112021007401-5A 2018-10-19 2019-10-21 esteroides neuroativos insaturados 9(11) e seus métodos de uso BR112021007401A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862748016P 2018-10-19 2018-10-19
US62/748,016 2018-10-19
PCT/US2019/057195 WO2020082065A1 (en) 2018-10-19 2019-10-21 9(11)-unsaturated neuroactive steroids and their methods of use

Publications (1)

Publication Number Publication Date
BR112021007401A2 true BR112021007401A2 (pt) 2021-08-03

Family

ID=68468867

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021007401-5A BR112021007401A2 (pt) 2018-10-19 2019-10-21 esteroides neuroativos insaturados 9(11) e seus métodos de uso

Country Status (13)

Country Link
US (2) US20210363175A1 (https=)
EP (2) EP3867261B1 (https=)
JP (2) JP7534291B2 (https=)
CN (1) CN113227114B (https=)
AR (1) AR116771A1 (https=)
AU (2) AU2019359899B2 (https=)
BR (1) BR112021007401A2 (https=)
CA (1) CA3116892A1 (https=)
DK (1) DK3867261T3 (https=)
ES (1) ES3039267T3 (https=)
MX (2) MX2021004452A (https=)
TW (1) TW202027754A (https=)
WO (1) WO2020082065A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201606063RA (en) 2012-01-23 2016-09-29 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
MX2015002252A (es) 2012-08-21 2015-07-21 Sage Therapeutics Inc Metodos para tratar epilepsia o estado de epilepsia.
JP6470258B2 (ja) 2013-04-17 2019-02-13 セージ セラピューティクス, インコーポレイテッド 19−ノルc3,3−ジ置換c21−n−ピラゾリルステロイドおよびその使用方法
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
TWI904593B (zh) 2016-08-23 2025-11-11 美商賽吉醫療公司 結晶19-去甲c3,3-二取代之c21-n-吡唑類固醇
EP3720867A1 (en) 2017-12-08 2020-10-14 Sage Therapeutics, Inc. Deuterated 21 -[4-cyano-pyrazol-1 -yl]-19-nor-pregan-3. alpha-ol-20-one derivatives for treating cns disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953429A (en) * 1970-12-17 1976-04-27 Glaxo Laboratories Limited Anaesthetic steroids of the androstance and pregnane series
DE2526373C2 (de) * 1975-06-11 1983-11-10 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von Δ↑9↑↑(↑↑1↑↑1↑↑)↑-5α-20-Ketosteroiden
JP2545522B2 (ja) * 1985-10-23 1996-10-23 アルコン・ラボラトーリーズ,インコーポレイテッド テトラヒドロ脈管形成抑制ステロイド
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
AU3967297A (en) * 1996-08-01 1998-02-25 Cocensys, Inc. Use of gaba and nmda receptor ligands for the treatment of migraine headache
US10577390B2 (en) * 2014-10-16 2020-03-03 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
MA45599A (fr) * 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation

Also Published As

Publication number Publication date
AU2024220209A1 (en) 2024-10-17
US20210363175A1 (en) 2021-11-25
EP3867261A1 (en) 2021-08-25
EP3867261B1 (en) 2025-04-30
TW202027754A (zh) 2020-08-01
EP4606812A2 (en) 2025-08-27
JP7534291B2 (ja) 2024-08-14
JP2022505146A (ja) 2022-01-14
US20250136638A1 (en) 2025-05-01
AU2019359899B2 (en) 2024-07-04
ES3039267T3 (en) 2025-10-20
CA3116892A1 (en) 2020-04-23
WO2020082065A1 (en) 2020-04-23
CN113227114A (zh) 2021-08-06
MX2021004452A (es) 2021-08-11
AR116771A1 (es) 2021-06-09
AU2019359899A1 (en) 2021-05-20
CN113227114B (zh) 2026-01-27
EP4606812A3 (en) 2025-10-15
MX2024014845A (es) 2025-01-09
JP2024096347A (ja) 2024-07-12
DK3867261T3 (da) 2025-08-18

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Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B154 Notification of filing of divisional application [chapter 15.50 patent gazette]

Free format text: O PEDIDO FOI DIVIDIDO NO BR122024013785-2 PROTOCOLO 870240056698 EM 04/07/2024 15:09.