TW201908335A - 增強之嵌合抗原受體及其用途 - Google Patents
增強之嵌合抗原受體及其用途Info
- Publication number
- TW201908335A TW201908335A TW107125720A TW107125720A TW201908335A TW 201908335 A TW201908335 A TW 201908335A TW 107125720 A TW107125720 A TW 107125720A TW 107125720 A TW107125720 A TW 107125720A TW 201908335 A TW201908335 A TW 201908335A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
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- C07K14/5443—IL-15
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N5/0634—Cells from the blood or the immune system
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762536934P | 2017-07-25 | 2017-07-25 | |
| US62/536,934 | 2017-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201908335A true TW201908335A (zh) | 2019-03-01 |
Family
ID=65040821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW107125720A TW201908335A (zh) | 2017-07-25 | 2018-07-25 | 增強之嵌合抗原受體及其用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240336699A1 (enExample) |
| EP (2) | EP4582146A2 (enExample) |
| JP (2) | JP2020530989A (enExample) |
| KR (1) | KR20200032174A (enExample) |
| CN (2) | CN118206655A (enExample) |
| AU (1) | AU2018306307B2 (enExample) |
| CA (1) | CA3070998A1 (enExample) |
| TW (1) | TW201908335A (enExample) |
| WO (1) | WO2019023396A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020106621A1 (en) * | 2018-11-19 | 2020-05-28 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
| WO2021032783A1 (en) | 2019-08-21 | 2021-02-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Methods for detecting, quantifying and monitoring immune-cell mediated cytotoxicity of cell populations comprising immune cells and/or stem cells |
| NL2023924B1 (nl) * | 2019-10-01 | 2021-06-01 | Lely Patent Nv | Meetsysteem voor levensmiddelen |
| CN115461361B (zh) * | 2020-05-08 | 2025-03-14 | 玛希敦大学 | 嵌合抗原受体和携带该受体的经修饰的细胞 |
| KR102297396B1 (ko) * | 2020-07-29 | 2021-09-06 | (주)티카로스 | 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포 |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| CN116981685A (zh) * | 2020-12-03 | 2023-10-31 | 世纪治疗股份有限公司 | 基因工程化细胞及其用途 |
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| BR112023021133A2 (pt) * | 2021-04-14 | 2023-12-12 | Univ Texas | Receptores quiméricos de antígenos para direcionar cânceres positivos para cd5 |
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| DE69233204T2 (de) * | 1991-12-13 | 2004-07-15 | Xoma Corp., Berkeley | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
| EP1648512A4 (en) | 2003-07-31 | 2009-01-21 | Immunomedics Inc | ANTI-CD19 ANTIBODIES |
| ES2911246T3 (es) * | 2009-11-03 | 2022-05-18 | Hope City | Receptor del factor de crecimiento epidérmico truncado (EGFRT) para selección de células T transducidas |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| RU2729401C2 (ru) | 2012-10-02 | 2020-08-06 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы для иммунотерапии |
| SG11201505896YA (en) * | 2013-02-20 | 2015-09-29 | Novartis Ag | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| KR102238226B1 (ko) * | 2013-05-14 | 2021-04-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (car) t-세포의 인간 적용 |
| EP3925618A1 (en) * | 2013-07-29 | 2021-12-22 | 2seventy bio, Inc. | Multipartite signaling proteins and uses thereof |
| KR20160145802A (ko) * | 2014-04-23 | 2016-12-20 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법 |
| HK1243441A1 (zh) * | 2014-11-05 | 2018-07-13 | Board Of Regents, The University Of Texas System | 基因修饰的免疫效应细胞和用於扩增免疫效应细胞的工程化细胞 |
| CA2973529A1 (en) * | 2015-01-26 | 2016-08-04 | Cellectis | Cll1-specific multi-chain chimeric antigen receptor |
| US10786549B2 (en) * | 2015-04-23 | 2020-09-29 | Baylor College Of Medicine | CD5 chimeric antigen receptor for adoptive T cell therapy |
| WO2017096329A1 (en) * | 2015-12-03 | 2017-06-08 | Juno Therapeutics, Inc. | Modified chimeric receptors and related compositions and methods |
| WO2017112877A1 (en) * | 2015-12-22 | 2017-06-29 | Icell Gene Therapeutics, Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
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| JP2020530989A (ja) | 2020-11-05 |
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