TW201907008A - 用於調節htra1表現之反義寡核苷酸 - Google Patents
用於調節htra1表現之反義寡核苷酸 Download PDFInfo
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Classifications
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- C12Y—ENZYMES
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- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21108—HtrA2 peptidase (3.4.21.108)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Public Health (AREA)
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- Wood Science & Technology (AREA)
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- Biophysics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| ??17173964.2 | 2017-06-01 | ||
| EP17173964 | 2017-06-01 | ||
| EP17209407 | 2017-12-21 | ||
| EP17209535 | 2017-12-21 | ||
| ??17209407.0 | 2017-12-21 | ||
| ??17209535.8 | 2017-12-21 |
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| TW201803990A (zh) | 2016-07-01 | 2018-02-01 | 赫孚孟拉羅股份公司 | 用於調節htra1表現之反股寡核苷酸 |
| US11332733B2 (en) | 2018-02-12 | 2022-05-17 | lonis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
| JP2023539474A (ja) * | 2020-08-20 | 2023-09-14 | ジノム オピニオン インコーポレイテッド | 加齢黄斑変性診断用バイオマーカーおよびこの用途 |
| KR20230095097A (ko) * | 2020-10-30 | 2023-06-28 | 히데아키 하라 | 눈 조직 섬유화의 저해에 사용하기 위한 gdf15 조절 물질 |
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| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| WO1999014226A2 (en) | 1997-09-12 | 1999-03-25 | Exiqon A/S | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleotide analogues |
| AU5290499A (en) * | 1998-08-03 | 2000-02-28 | Novartis Ag | Human htra serine protease |
| ATE287897T2 (de) | 1999-02-12 | 2005-02-15 | Sankyo Co | Analoga von nukleosiden und oligonukleotiden |
| CN102180924A (zh) | 1999-05-04 | 2011-09-14 | 桑塔里斯制药公司 | L-核糖-lna类似物 |
| US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
| CA2506576C (en) | 2002-11-18 | 2018-03-06 | Santaris Pharma A/S | Antisense gapmer oligonucleotides |
| CA2609180A1 (en) * | 2005-05-24 | 2006-11-30 | Isis Pharmaceuticals, Inc. | Modulation of lmw-ptpase expression |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| JP5342881B2 (ja) | 2006-01-27 | 2013-11-13 | アイシス ファーマシューティカルズ， インコーポレーテッド | ６−修飾された二環式核酸類似体 |
| US7547684B2 (en) | 2006-05-11 | 2009-06-16 | Isis Pharmaceuticals, Inc. | 5′-modified bicyclic nucleic acid analogs |
| US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
| US20110052602A1 (en) * | 2006-07-26 | 2011-03-03 | Yale University | Diagnosis and Treatment of Age Related Macular Degeneration |
| WO2008067040A2 (en) * | 2006-10-06 | 2008-06-05 | University Of Utah Research Foundation | Method of detecting ocular diseases and pathologic conditions and treatment of same |
| EP2170917B1 (en) | 2007-05-30 | 2012-06-27 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| TW200911290A (en) * | 2007-07-02 | 2009-03-16 | Alcon Res Ltd | RNAI-mediated inhibition of HTRA1 for treatment of macular degeneration |
| CA2692579C (en) | 2007-07-05 | 2016-05-03 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| AU2008318316B2 (en) * | 2007-11-01 | 2015-08-06 | University Of Iowa Research Foundation | RCA locus analysis to assess susceptibility to AMD and MPGNII |
| WO2009067647A1 (en) | 2007-11-21 | 2009-05-28 | Isis Pharmaceuticals, Inc. | Carbocyclic alpha-l-bicyclic nucleic acid analogs |
| WO2010036698A1 (en) | 2008-09-24 | 2010-04-01 | Isis Pharmaceuticals, Inc. | Substituted alpha-l-bicyclic nucleosides |
| EP2462153B1 (en) | 2009-08-06 | 2015-07-29 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
| US8846637B2 (en) | 2010-06-08 | 2014-09-30 | Isis Pharmaceuticals, Inc. | Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom |
| FR2965278B1 (fr) * | 2010-09-23 | 2014-10-10 | Univ Caen Basse Normandie | Procede d'obtention in vitro ou ex vivo de chondrocytes et leurs utilisations |
| US9751909B2 (en) | 2011-09-07 | 2017-09-05 | Marina Biotech, Inc. | Synthesis and uses of nucleic acid compounds with conformationally restricted monomers |
| EP2850092B1 (en) | 2012-04-09 | 2017-03-01 | Ionis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
| WO2013173637A1 (en) * | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating gene expression |
| RU2015119411A (ru) | 2012-11-15 | 2017-01-10 | Рош Инновейшен Сентер Копенгаген А/С | Конъюгаты антисмысловых соединений, направленные на аполипопротеин в |
| WO2018087200A1 (en) * | 2016-11-11 | 2018-05-17 | Roche Innovation Center Copenhagen A/S | Therapeutic oligonucleotides capture and detection |
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- 2018-05-30 EP EP18727310.7A patent/EP3630976A1/en active Pending
- 2018-05-30 RU RU2019143004A patent/RU2019143004A/ru unknown
- 2018-05-30 MX MX2019014187A patent/MX2019014187A/es unknown
- 2018-05-30 CA CA3062590A patent/CA3062590A1/en not_active Abandoned
- 2018-05-30 PE PE2019002473A patent/PE20191845A1/es unknown
- 2018-05-30 AU AU2018277219A patent/AU2018277219A1/en not_active Abandoned
- 2018-05-30 JP JP2019566236A patent/JP7169995B2/ja active Active
- 2018-05-30 WO PCT/EP2018/064221 patent/WO2018220034A1/en not_active Ceased
- 2018-05-30 MA MA049278A patent/MA49278A/fr unknown
- 2018-05-30 CN CN201880036053.5A patent/CN110691849A/zh active Pending
- 2018-05-30 BR BR112019025290-8A patent/BR112019025290A2/pt not_active Application Discontinuation
- 2018-05-30 KR KR1020197038723A patent/KR20200015608A/ko not_active Withdrawn
- 2018-05-30 CR CR20190543A patent/CR20190543A/es unknown
- 2018-05-31 TW TW107118609A patent/TW201907008A/zh unknown
-
2019
- 2019-10-28 US US16/665,317 patent/US20200157546A1/en not_active Abandoned
- 2019-11-20 CL CL2019003337A patent/CL2019003337A1/es unknown
- 2019-11-22 PH PH12019502636A patent/PH12019502636A1/en unknown
- 2019-11-27 CO CONC2019/0013317A patent/CO2019013317A2/es unknown
- 2019-11-28 IL IL271039A patent/IL271039A/en unknown
-
2021
- 2021-08-17 US US17/404,989 patent/US20220042022A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018220034A1 (en) | 2018-12-06 |
| US20190055564A1 (en) | 2019-02-21 |
| KR20200015608A (ko) | 2020-02-12 |
| CL2019003337A1 (es) | 2020-05-15 |
| PH12019502636A1 (en) | 2020-06-08 |
| CO2019013317A2 (es) | 2020-01-17 |
| EP3630976A1 (en) | 2020-04-08 |
| BR112019025290A2 (pt) | 2020-06-23 |
| RU2019143004A (ru) | 2021-07-09 |
| CR20190543A (es) | 2020-02-10 |
| JP7169995B2 (ja) | 2022-11-11 |
| JP2020521491A (ja) | 2020-07-27 |
| CA3062590A1 (en) | 2018-12-06 |
| PE20191845A1 (es) | 2019-12-31 |
| IL271039A (en) | 2020-01-30 |
| MA49278A (fr) | 2020-04-08 |
| CN110691849A (zh) | 2020-01-14 |
| MX2019014187A (es) | 2020-01-27 |
| US20200157546A1 (en) | 2020-05-21 |
| AU2018277219A1 (en) | 2019-12-19 |
| US20220042022A1 (en) | 2022-02-10 |
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