TW201828959A - 精胺酸酶抑制劑組合療法 - Google Patents
精胺酸酶抑制劑組合療法 Download PDFInfo
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- TW201828959A TW201828959A TW106138689A TW106138689A TW201828959A TW 201828959 A TW201828959 A TW 201828959A TW 106138689 A TW106138689 A TW 106138689A TW 106138689 A TW106138689 A TW 106138689A TW 201828959 A TW201828959 A TW 201828959A
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- alkyl
- aryl
- heterocycloalkyl
- alkylene
- cancer
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| US12215116B2 (en) | 2018-03-13 | 2025-02-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| AU2019246728A1 (en) | 2018-03-29 | 2020-08-27 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
| CA3098471C (en) * | 2018-05-22 | 2023-04-18 | Nantkwest, Inc. | Optimization of nk-92 cell growth using poloxamer |
| MA53427B1 (fr) * | 2018-08-22 | 2024-06-28 | Astrazeneca Ab | Inhibiteurs de l'arginase et leurs méthodes d'utilisation |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3880685B1 (en) * | 2018-11-16 | 2025-06-18 | Arcus Biosciences, Inc. | Inhibitors of arg1 and/or arg2 |
| CN113614095B (zh) * | 2019-02-06 | 2024-08-23 | 广东新契生物医药科技有限公司 | 作为精氨酸酶抑制剂的烷基硼酸类化合物 |
| WO2021090146A1 (en) * | 2019-11-04 | 2021-05-14 | Astrazeneca Ab | Combination therapy for treating cancer |
| CN110734456A (zh) * | 2019-11-06 | 2020-01-31 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和医药上的应用 |
| CN111138358B (zh) * | 2019-12-17 | 2023-04-18 | 中国药科大学 | Usp8抑制剂及其制备方法与应用 |
| EP4251202A4 (en) * | 2020-11-30 | 2025-04-09 | Merck Sharp & Dohme LLC | ARGINASE-1 BINDING AGENT FOR INHIBITING ARGINASE-1 ACTIVITY |
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| JP2024507199A (ja) * | 2021-02-20 | 2024-02-16 | カイト ファーマ インコーポレイテッド | 免疫療法を選択するための遺伝子マーカー |
| US12653889B2 (en) * | 2021-04-06 | 2026-06-16 | Smt Bio Co., Ltd. | Composition for preventing or treating extrahepatic bile duct cancer |
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Family Cites Families (28)
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| DE69818675T2 (de) | 1997-07-29 | 2004-07-29 | Alcon Laboratories, Inc., Fort Worth | Galaktomannanpolymere und borat enthaltende augenarzneimittel |
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| AU2483599A (en) | 1998-01-29 | 1999-08-16 | Sepracor, Inc. | Pharmaceutical uses of optically pure (-)-bupropion |
| US20040063666A1 (en) | 1998-10-09 | 2004-04-01 | David Christianson | Compositions for inhibiting arginase activity |
| US8889112B2 (en) | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
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| EP1915143A4 (en) | 2005-07-01 | 2009-11-11 | Univ Johns Hopkins | ARGINASE II: TARGET TREATMENT FOR THE AGING HEART AND HEART FAILURE |
| WO2010085797A2 (en) | 2009-01-26 | 2010-07-29 | The Trustees Of University Of Pennsylvania | Arginase inhibitors and methods of use |
| EP2560978B1 (en) | 2010-04-22 | 2019-01-30 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| EP3034509B1 (en) * | 2010-10-26 | 2020-04-22 | Mars, Incorporated | Arginase inhibitors as therapeutics |
| RU2019121905A (ru) | 2010-12-31 | 2019-09-03 | Астразенека Юкей Лимитед | Ингибиторы аргиназы и способы их применения |
| CA2852685C (en) | 2011-10-19 | 2019-02-26 | Mars, Incorporated | Inhibitors of arginase and their therapeutic application |
| KR20140077963A (ko) | 2011-10-20 | 2014-06-24 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체 |
| CN104540836B (zh) | 2012-04-18 | 2016-11-09 | 马尔斯公司 | 作为精氨酸酶抑制剂的环约束类似物 |
| WO2015061752A1 (en) | 2013-10-25 | 2015-04-30 | Pharmacyclics, Inc. | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy |
| CN105879030A (zh) | 2014-09-30 | 2016-08-24 | 复旦大学 | 治疗肿瘤的增效药物复合物及其制备方法 |
| KR20170129896A (ko) | 2015-03-20 | 2017-11-27 | 새미 오유 오피요 | 악성 신생물에 대한 수라민 및 아르기나아제 억제제의 용도 |
| AU2016281620B2 (en) | 2015-06-23 | 2021-07-22 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| DK3368541T3 (da) | 2015-10-30 | 2020-06-29 | Calithera Biosciences Inc | Sammensætninger og metoder til inhibiering af arginaseaktivitet |
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