TW201817732A - 螺環化合物 - Google Patents

螺環化合物 Download PDF

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Publication number
TW201817732A
TW201817732A TW106134299A TW106134299A TW201817732A TW 201817732 A TW201817732 A TW 201817732A TW 106134299 A TW106134299 A TW 106134299A TW 106134299 A TW106134299 A TW 106134299A TW 201817732 A TW201817732 A TW 201817732A
Authority
TW
Taiwan
Prior art keywords
cancer
group
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
TW106134299A
Other languages
English (en)
Chinese (zh)
Inventor
琴華 黃
梅赫梅 凱拉曼
凱文 杜安 班納
Original Assignee
美商凱立拉製藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商凱立拉製藥公司 filed Critical 美商凱立拉製藥公司
Publication of TW201817732A publication Critical patent/TW201817732A/zh

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW106134299A 2016-10-05 2017-10-05 螺環化合物 TW201817732A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662404668P 2016-10-05 2016-10-05
US62/404,668 2016-10-05

Publications (1)

Publication Number Publication Date
TW201817732A true TW201817732A (zh) 2018-05-16

Family

ID=61831517

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106134299A TW201817732A (zh) 2016-10-05 2017-10-05 螺環化合物

Country Status (13)

Country Link
US (2) US10934304B2 (enExample)
EP (1) EP3523306A4 (enExample)
JP (2) JP6949952B2 (enExample)
KR (1) KR20190075931A (enExample)
CN (1) CN109890827A (enExample)
AU (1) AU2017339890A1 (enExample)
BR (1) BR112019005305A2 (enExample)
CA (1) CA3037064A1 (enExample)
IL (1) IL265752A (enExample)
MX (1) MX2019003938A (enExample)
RU (1) RU2019107667A (enExample)
TW (1) TW201817732A (enExample)
WO (1) WO2018067512A1 (enExample)

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EP3176170B1 (en) 2012-06-13 2018-11-14 Incyte Holdings Corporation Substituted tricyclic compounds as fgfr inhibitors
SG10201708520YA (en) 2013-04-19 2017-12-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
MX373169B (es) 2015-02-20 2020-04-24 Incyte Holdings Corp Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr).
CA2981055A1 (en) 2015-04-03 2016-10-06 Kalyra Pharmaceuticals, Inc. Spirocyclic compounds
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CR20240498A (es) 2018-05-04 2025-01-08 Incyte Corp FORMAS SÓLIDAS DE UN INHIBIDOR DE FGFR Y PROCESOS PARA PREPARARLAS (Divisional EXP. 2020-0590)
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
AU2019334264B2 (en) * 2018-09-07 2024-10-31 Merck Patent Gmbh 5-Morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JOP20220083A1 (ar) 2019-10-14 2023-01-30 Incyte Corp حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
PE20221504A1 (es) 2019-12-04 2022-09-30 Incyte Corp Derivados de un inhibidor de fgfr
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CN110922421B (zh) * 2019-12-17 2023-05-05 安徽英特美科技有限公司 一种n-甲基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4323405A1 (en) 2021-04-12 2024-02-21 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
JP2024522188A (ja) 2021-06-09 2024-06-11 インサイト・コーポレイション Fgfr阻害剤としての三環式ヘテロ環
EP4352059A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
TW202535881A (zh) * 2023-10-31 2025-09-16 美商C4醫藥公司 用於降解突變braf之化合物

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EP3943489A1 (en) * 2004-05-14 2022-01-26 Vertex Pharmaceuticals Incorporated Pyrrole inhibitors of erk protein kinase, synthesis thereof and intermediates thereto
PL1966151T3 (pl) 2005-12-13 2012-02-29 Merck Sharp & Dohme Policykliczne pochodne indazoli jako inhibitory ERK
EP2086974B1 (en) 2006-11-17 2013-07-24 Polyera Corporation Diimide-based semiconductor materials and methods of preparing and using the same
WO2008156739A1 (en) * 2007-06-18 2008-12-24 Schering Corporation Heterocyclic compounds and use thereof as erk inhibitors
US20110166124A1 (en) 2008-07-23 2011-07-07 Mccormick Kevin D Tricyclic spirocycle derivatives and methods of use
EP3296398A1 (en) 2009-12-07 2018-03-21 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
US8664213B2 (en) 2011-08-29 2014-03-04 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as HIV attachment inhibitors
CN103130775B (zh) 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
US8987264B2 (en) * 2012-11-09 2015-03-24 Bristol-Myers Squibb Company 1,3,5-triazine derivatives of spiro bicyclic oxalamide-compounds for treatment of hepatitis C
JP6506248B2 (ja) 2013-03-14 2019-04-24 ゾーン・ロイヤリティズ・アンド・マイルストーンズ・エルエルシー 二環式鎮痛化合物
JP6322770B2 (ja) 2014-12-22 2018-05-09 イーライ リリー アンド カンパニー Erk阻害剤
CN105732636B (zh) * 2014-12-30 2020-04-21 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
CA2981055A1 (en) * 2015-04-03 2016-10-06 Kalyra Pharmaceuticals, Inc. Spirocyclic compounds

Also Published As

Publication number Publication date
KR20190075931A (ko) 2019-07-01
WO2018067512A1 (en) 2018-04-12
CN109890827A (zh) 2019-06-14
IL265752A (en) 2019-06-30
MX2019003938A (es) 2019-06-10
RU2019107667A (ru) 2020-11-06
NZ751398A (en) 2021-03-26
US10934304B2 (en) 2021-03-02
AU2017339890A1 (en) 2019-04-11
US20200207776A1 (en) 2020-07-02
EP3523306A4 (en) 2020-05-06
CA3037064A1 (en) 2018-04-12
JP6949952B2 (ja) 2021-10-13
EP3523306A1 (en) 2019-08-14
BR112019005305A2 (pt) 2019-07-02
JP2021193138A (ja) 2021-12-23
US20210115058A1 (en) 2021-04-22
JP2019534261A (ja) 2019-11-28
RU2019107667A3 (enExample) 2021-01-27
WO2018067512A8 (en) 2018-11-01

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