TW201740101A - 用於時間分辨螢光光譜法的系統、裝置和方法 - Google Patents

用於時間分辨螢光光譜法的系統、裝置和方法

Info

Publication number
TW201740101A
TW201740101A TW106111283A TW106111283A TW201740101A TW 201740101 A TW201740101 A TW 201740101A TW 106111283 A TW106111283 A TW 106111283A TW 106111283 A TW106111283 A TW 106111283A TW 201740101 A TW201740101 A TW 201740101A
Authority
TW
Taiwan
Prior art keywords
signal
optical
biological sample
response
probe
Prior art date
Application number
TW106111283A
Other languages
English (en)
Chinese (zh)
Inventor
普雷默德 巴特
肯斯 布雷克
傑克 卡凡納吉
Original Assignee
黑光外科公司
美國錫安山醫學中心
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 黑光外科公司, 美國錫安山醫學中心 filed Critical 黑光外科公司
Publication of TW201740101A publication Critical patent/TW201740101A/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2889—Rapid scan spectrometers; Time resolved spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/32—Investigating bands of a spectrum in sequence by a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1213—Filters in general, e.g. dichroic, band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1265—Generating the spectrum; Monochromators the wavelengths being separated in time, e.g. through optical fibre array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106—General arrangement of respective parts
    • G01N2021/0112—Apparatus in one mechanical, optical or electronic block
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Laser Surgery Devices (AREA)
  • Surgical Instruments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
TW106111283A 2016-04-01 2017-03-31 用於時間分辨螢光光譜法的系統、裝置和方法 TW201740101A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201662317460P 2016-04-01 2016-04-01
US201662317455P 2016-04-01 2016-04-01
US201662317453P 2016-04-01 2016-04-01
US201662317449P 2016-04-01 2016-04-01
US201662317451P 2016-04-01 2016-04-01
US201662317456P 2016-04-01 2016-04-01
US201662317459P 2016-04-01 2016-04-01
US201662317452P 2016-04-01 2016-04-01
US201662317443P 2016-04-01 2016-04-01
US201662351615P 2016-06-17 2016-06-17

Publications (1)

Publication Number Publication Date
TW201740101A true TW201740101A (zh) 2017-11-16

Family

ID=59961177

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106111283A TW201740101A (zh) 2016-04-01 2017-03-31 用於時間分辨螢光光譜法的系統、裝置和方法

Country Status (7)

Country Link
US (4) US10656089B2 (cg-RX-API-DMAC7.html)
EP (1) EP3436805A4 (cg-RX-API-DMAC7.html)
JP (3) JP7266519B2 (cg-RX-API-DMAC7.html)
CN (2) CN115561211A (cg-RX-API-DMAC7.html)
CA (1) CA3019590A1 (cg-RX-API-DMAC7.html)
TW (1) TW201740101A (cg-RX-API-DMAC7.html)
WO (1) WO2017173315A1 (cg-RX-API-DMAC7.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11172826B2 (en) 2016-03-08 2021-11-16 Enspectra Health, Inc. Non-invasive detection of skin disease
US11633149B2 (en) 2017-04-28 2023-04-25 Enspectra Health, Inc. Systems and methods for imaging and measurement of sarcomeres
US12285236B2 (en) 2018-11-13 2025-04-29 Enspectra Health, Inc. Methods and systems for generating depth profiles with improved optical resolution
US12514453B2 (en) 2023-08-02 2026-01-06 Enspectra Health, Inc. Non-invasive detection of skin disease

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014168734A1 (en) 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
EP3436805A4 (en) 2016-04-01 2019-12-11 Black Light Surgical, Inc. SYSTEMS, DEVICES AND METHODS FOR TIME-RESOLUTION FLUORESCENCE SPECTROSCOPY
JP2018183088A (ja) * 2017-04-26 2018-11-22 アズビル株式会社 細胞生存率判定装置
EP3486688A1 (en) 2017-11-19 2019-05-22 Sensonica Limited Radiation detection apparatus and method
US10908289B2 (en) * 2017-11-19 2021-02-02 Sensonica Limited Navigation system, navigation method and receivers
JP2019196949A (ja) * 2018-05-09 2019-11-14 学校法人光産業創成大学院大学 光干渉装置、及び、ｏｃｔ装置
US10705019B2 (en) 2018-05-29 2020-07-07 The Boeing Company Multi-wavelength laser inspection
US11427804B2 (en) 2018-06-15 2022-08-30 Abs Global, Inc. Apparatus and method for cell kill confirmation
JP7281987B2 (ja) * 2018-07-11 2023-05-26 レーザーテック株式会社 光源、検査装置、ｅｕｖ光の生成方法及び検査方法
WO2020022394A1 (en) * 2018-07-24 2020-01-30 Sony Corporation Information processing apparatus and microscope for separating the fluorescence of a fluorescent reageant from the autofluorescence of a specimen
US11255783B2 (en) 2018-08-30 2022-02-22 Board Of Trustee Of The University Of Arkansas Systems and processes for early detection of biological ammonia oxidation in water using fluorometry
CN113424048A (zh) * 2019-03-25 2021-09-21 人工智能生物医学公司 组织检测系统及其使用方法
CN110208240A (zh) * 2019-04-08 2019-09-06 大连理工大学 基于时间域频率域压制杂散光的太赫兹拉曼光谱检测装置
DE102019110160B4 (de) * 2019-04-17 2023-07-27 Leica Microsystems Cms Gmbh Fluoreszenzmikroskop und Verfahren zur Abbildung einer Probe
EP3795982B1 (en) * 2019-09-18 2022-10-26 Centre National de la Recherche Scientifique Method and apparatus for detecting a photochemically active chemical species in a sample
CN110579458A (zh) * 2019-09-25 2019-12-17 深圳市太赫兹科技创新研究院有限公司 一种荧光光谱的测试装置以及荧光光谱的测试方法
FI20195947A1 (en) * 2019-11-05 2021-05-06 Timegate Instr Oy Apparatus for measuring raman spectrum and method thereof
EP4096505A1 (en) * 2020-01-29 2022-12-07 King's College London Raman spectroscopy method and system
CN112129702B (zh) * 2020-09-16 2022-08-26 飞秒激光研究中心（广州）有限公司 多模态信号采集装置及方法、激光影像系统
JP7646176B2 (ja) * 2020-09-28 2025-03-17 学校法人福岡大学 医療用蛍光装置
EP3973854A1 (en) * 2020-09-29 2022-03-30 Koninklijke Philips N.V. An optical spectroscopy system
US12359554B2 (en) 2021-03-15 2025-07-15 Saudi Arabian Oil Company Real-time multimodal radiometry for subsurface characterization during high-power laser operations
KR102432200B1 (ko) * 2021-03-25 2022-08-12 재단법인 오송첨단의료산업진흥재단 형광정보 및 산성도 정보를 이용한 진단시스템 및 이를 이용한 진단방법
US11725504B2 (en) 2021-05-24 2023-08-15 Saudi Arabian Oil Company Contactless real-time 3D mapping of surface equipment
US11619097B2 (en) 2021-05-24 2023-04-04 Saudi Arabian Oil Company System and method for laser downhole extended sensing
US11783938B2 (en) 2021-07-22 2023-10-10 Cilag Gmbh International Integrated hub systems control interfaces and connections
KR102549928B1 (ko) * 2021-07-28 2023-06-30 주식회사 메타플바이오 멀티스펙트럼 광 조사 장치 및 멀티스펙트럼 형광 이미징 시스템
WO2023034875A1 (en) 2021-08-31 2023-03-09 Saudi Arabian Oil Company Quantitative hydraulic fracturing surveillance from fiber optic sensing using machine learning
KR20240132443A (ko) * 2021-11-11 2024-09-03 블랙 라이트 서지컬, 인크. 조직 특성화를 위한 시스템 및 방법
US12085687B2 (en) 2022-01-10 2024-09-10 Saudi Arabian Oil Company Model-constrained multi-phase virtual flow metering and forecasting with machine learning
CN114732448A (zh) * 2022-03-23 2022-07-12 广州医科大学附属第五医院 基于荧光寿命和拉曼光谱成像的甲状腺手术内镜装置
CN115541553B (zh) * 2022-11-25 2023-03-14 哈尔滨星云医学检验所有限公司 一种用于生物特征信息提取的输入和输出集成系统
WO2024138224A1 (en) * 2022-12-24 2024-06-27 Dignity Health Systems and methods for 3-dimensional anatomical reconstruction using monoscopic photogrammetry
DE102023109877A1 (de) 2023-04-19 2024-04-11 Carl Zeiss Meditec Ag Mehrere bildgebungsmodalitäten für ein holographisch-endoskopisches bildgebungssystem
CN116148227B (zh) 2023-04-23 2023-07-28 广东大湾区空天信息研究院 时间分辨光谱快速测量系统及方法
US20250090055A1 (en) * 2023-09-20 2025-03-20 Alexandre Ivachtchenko Method and device for determining ischemic injuries of mammalian organs and tissues

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7500951A (nl) 1975-01-28 1976-07-30 Akzo Nv Fluorimetrisch aantonen en bepalen van een gereduceerd co-enzym of derivaat in een waterig systeem.
US5464013A (en) 1984-05-25 1995-11-07 Lemelson; Jerome H. Medical scanning and treatment system and method
US5419323A (en) 1988-12-21 1995-05-30 Massachusetts Institute Of Technology Method for laser induced fluorescence of tissue
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US4937457A (en) 1989-02-10 1990-06-26 Slm Instruments, Inc. Picosecond multi-harmonic fourier fluorometer
WO1990009637A1 (en) 1989-02-13 1990-08-23 Research Corporation Technologies, Inc. Method and means for parallel frequency acquisition in frequency domain fluorometry
US5151869A (en) 1990-02-16 1992-09-29 The Boc Group, Inc. Frequency domain fluorometry using coherent sampling
US5196709A (en) 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5762609A (en) 1992-09-14 1998-06-09 Sextant Medical Corporation Device and method for analysis of surgical tissue interventions
US5462879A (en) * 1993-10-14 1995-10-31 Minnesota Mining And Manufacturing Company Method of sensing with emission quenching sensors
US5749830A (en) * 1993-12-03 1998-05-12 Olympus Optical Co., Ltd. Fluorescent endoscope apparatus
JPH07222712A (ja) * 1994-02-10 1995-08-22 Olympus Optical Co Ltd 蛍光内視鏡装置
JP3448090B2 (ja) 1994-02-16 2003-09-16 浜松ホトニクス株式会社 エネルギー移動検出法およびその装置
US5701902A (en) 1994-09-14 1997-12-30 Cedars-Sinai Medical Center Spectroscopic burn injury evaluation apparatus and method
US6258576B1 (en) 1996-06-19 2001-07-10 Board Of Regents, The University Of Texas System Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy
US5991653A (en) 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
JP3980683B2 (ja) 1995-08-29 2007-09-26 仁 岩崎 還元型ニコチンアミド補酵素の測定用試薬および測定方法
US5769081A (en) 1996-03-18 1998-06-23 The Research Foundation Of City College Of New York Method for detecting cancerous tissue using optical spectroscopy and fourier analysis
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US6124597A (en) 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
US6051437A (en) * 1998-05-04 2000-04-18 American Research Corporation Of Virginia Optical chemical sensor based on multilayer self-assembled thin film sensors for aquaculture process control
US6571118B1 (en) * 1998-05-04 2003-05-27 Board Of Regents, The University Of Texas System Combined fluorescence and reflectance spectroscopy
EP1102977A1 (en) 1998-08-08 2001-05-30 Imperial Cancer Research Technology Limited Fluorescence assay for biological systems
US6246817B1 (en) * 1998-09-01 2001-06-12 Innova Quartz Inc. Optical fiber with numerical aperture compression
IL141864A0 (en) 1998-09-11 2002-03-10 Spectrx Inc Multi-modal optical tissue diagnostic system
EP1139864A1 (en) 1998-12-23 2001-10-10 Medispectra Inc. Optical methods and systems for cervical screening
US6272376B1 (en) 1999-01-22 2001-08-07 Cedars-Sinai Medical Center Time-resolved, laser-induced fluorescence for the characterization of organic material
US6097485A (en) 1999-03-08 2000-08-01 Integrated Waveguides, Inc. Microchip optical transport technology for use in a personal flow cytometer
US6697666B1 (en) 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
AU6754900A (en) 1999-08-03 2001-02-19 Biophysica, Llc Spectroscopic systems and methods for detecting tissue properties
US7904139B2 (en) 1999-08-26 2011-03-08 Non-Invasive Technology Inc. Optical examination of biological tissue using non-contact irradiation and detection
US7260248B2 (en) 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
GR1004180B (el) 2000-03-28 2003-03-11 ����������� ����� ��������� (����) Μεθοδος και συστημα χαρακτηρισμου και χαρτογραφησης αλλοιωσεων των ιστων
US6889075B2 (en) 2000-05-03 2005-05-03 Rocky Mountain Biosystems, Inc. Optical imaging of subsurface anatomical structures and biomolecules
CA2411465C (en) 2000-06-08 2013-08-27 The Regents Of The University Of California Visual-servoing optical microscopy
US7546210B2 (en) 2000-06-08 2009-06-09 The Regents Of The University Of California Visual-servoing optical microscopy
AU2001272003A1 (en) 2000-07-13 2002-02-05 Virginia Commonwealth University Use of ultraviolet, near-ultraviolet and near infrared resonance raman spectroscopy and fluorescence spectroscopy for tissue interrogation of shock states, critical illnesses, and other disease states
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6826424B1 (en) 2000-12-19 2004-11-30 Haishan Zeng Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices
US6697652B2 (en) 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
US7015484B2 (en) 2001-04-16 2006-03-21 Dakota Technologies, Inc. Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures
US6929779B2 (en) * 2001-06-22 2005-08-16 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation output
GB2382648B (en) 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
US20030136921A1 (en) 2002-01-23 2003-07-24 Reel Richard T Methods for fluorescence detection that minimizes undesirable background fluorescence
US7647092B2 (en) * 2002-04-05 2010-01-12 Massachusetts Institute Of Technology Systems and methods for spectroscopy of biological tissue
US20060193905A1 (en) 2002-05-14 2006-08-31 University Of Louisville Research Foundation, Inc. Direct cellular energy delivery system
US6933154B2 (en) 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US7136518B2 (en) 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US6768918B2 (en) 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US7103401B2 (en) 2002-07-10 2006-09-05 Medispectra, Inc. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7192783B2 (en) 2003-02-05 2007-03-20 Research Foundation Of The City University Of New York Stokes shift emission spectroscopy for detection of disease and physiological state of specimen
JP2004305382A (ja) * 2003-04-04 2004-11-04 Olympus Corp 特殊光観察システム
US20040225222A1 (en) * 2003-05-08 2004-11-11 Haishan Zeng Real-time contemporaneous multimodal imaging and spectroscopy uses thereof
US7890157B2 (en) 2003-08-19 2011-02-15 Cedars-Sinai Medical Center Method for fluorescence lifetime imaging microscopy and spectroscopy
US20050105791A1 (en) * 2003-10-29 2005-05-19 Lee Ken K. Surface inspection method
EP1754257B1 (en) * 2004-06-07 2013-12-25 Fluidigm Corporation Optical lens system and method for microfluidic devices
WO2006015251A2 (en) * 2004-07-29 2006-02-09 The Research Foundation Of State University Of New York System and method for cross-talk cancellation in a multilane fluorescence detector
EP1784633B1 (en) 2004-09-01 2011-11-09 Perkinelmer Singapore PTE Ltd. A method of analysing a sample and apparatus therefor
US20060229515A1 (en) * 2004-11-17 2006-10-12 The Regents Of The University Of California Fiber optic evaluation of tissue modification
US7423751B2 (en) 2005-02-08 2008-09-09 Northrop Grumman Corporation Systems and methods for use in detecting harmful aerosol particles
US7709249B2 (en) 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
CN101156059B (zh) 2005-04-01 2011-06-08 3M创新有限公司 具有将多个光学模块连接到公共检测器的纤维束的多重荧光检测装置
AU2006272332B2 (en) * 2005-07-18 2012-11-01 Quantum Dental Technologies Inc. Method and apparatus using infrared photothermal radiometry (PTR) and modulated laser luminescence (LUM) for diagnostics of defects in teeth
CN1912587A (zh) * 2005-08-12 2007-02-14 深圳大学 时间分辨荧光光谱测量和成像方法及其装置
GB2429521A (en) 2005-08-18 2007-02-28 E2V Tech CCD device for time resolved spectroscopy
US8057408B2 (en) 2005-09-22 2011-11-15 The Regents Of The University Of Michigan Pulsed cavitational ultrasound therapy
WO2008034070A2 (en) * 2006-09-15 2008-03-20 Pathologics Associates, Inc. Improved method for biomolecular detection and system thereof
US7824902B2 (en) * 2006-11-03 2010-11-02 Mark Selker Optical interface for disposable bioreactors
US8405827B2 (en) 2006-11-21 2013-03-26 Ricardo Claps Time-resolved spectroscopy system and methods for multiple-species analysis in fluorescence and cavity-ringdown applications
US8089625B2 (en) * 2006-11-28 2012-01-03 The Regents Of The University Of California Time-resolved and wavelength-resolved spectroscopy for characterizing biological materials
US20100069720A1 (en) 2006-11-30 2010-03-18 Newton Laboratories, Inc. Spectroscopically enhanced imaging
WO2008095075A1 (en) * 2007-02-01 2008-08-07 Ls Biopath, Inc. Optical system for identification and characterization of abnormal tissue and cells
WO2008144760A1 (en) 2007-05-21 2008-11-27 Board Of Regents, The University Of Texas System Optical methods to intraoperatively detect positive prostate and kidney cancer margins
US9226731B2 (en) * 2007-05-21 2016-01-05 The Board Of Regents Of The University Of Texas System Optically guided needle biopsy system using multi-modal spectroscopy in combination with a transrectal ultrasound probe
KR100885927B1 (ko) 2007-10-16 2009-02-26 광주과학기술원 형광수명 측정 방법 및 장치
US20090099460A1 (en) * 2007-10-16 2009-04-16 Remicalm Llc Method and device for the optical spectroscopic identification of cervical cancer
AU2008324814B2 (en) 2007-11-05 2013-05-16 Solventum Intellectual Properties Company Identification of tissue for debridement
US8694266B2 (en) 2008-06-05 2014-04-08 The Regents Of The University Of Michigan Multimodal spectroscopic systems and methods for classifying biological tissue
US20100234684A1 (en) * 2009-03-13 2010-09-16 Blume Jurgen Multifunctional endoscopic device and methods employing said device
US8264694B2 (en) 2009-03-16 2012-09-11 Ut-Battelle, Llc Quantitative phase-contrast and excitation-emission systems
JP2011062348A (ja) 2009-09-17 2011-03-31 Fujifilm Corp 内視鏡システム
CN102770071B (zh) * 2009-12-15 2015-03-25 爱默蕾大学 用于在诊断或治疗程序中提供实时解剖学指导的系统和方法
CN101788477B (zh) * 2010-01-12 2012-01-18 福建师范大学 一种具有氧分压和光敏剂荧光监测功能的单态氧检测装置
US20130076861A1 (en) 2010-01-21 2013-03-28 Shmuel Sternklar Method and apparatus for probing an object, medium or optical path using noisy light
JP5704827B2 (ja) 2010-03-19 2015-04-22 オリンパス株式会社 蛍光観察装置
US8735818B2 (en) * 2010-03-31 2014-05-27 Thermo Finnigan Llc Discrete dynode detector with dynamic gain control
CN101816552B (zh) * 2010-05-11 2011-06-22 天津大学 仿ct扫描模式多光谱时域荧光分子层析测量系统
US20130087718A1 (en) * 2010-06-28 2013-04-11 Ge Healthcare Bio-Sciences Corp. Confocal fluorescence lifetime imaging system
US9662047B2 (en) * 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
WO2012048063A2 (en) 2010-10-06 2012-04-12 Emd Millipore Corporation Cyanine compounds, conjugates and method of use
CN102525481B (zh) * 2011-12-14 2014-03-19 山东大学 一种基于近红外光谱的人体内酒精含量检测方法及系统
CA2865948A1 (en) 2012-03-02 2013-09-06 Warren S. Grundfest System and method for time-resolved fluorescence imaging and pulse shaping
US10517483B2 (en) 2012-12-05 2019-12-31 Accuvein, Inc. System for detecting fluorescence and projecting a representative image
CN105358947B (zh) * 2013-02-14 2018-03-16 曾海山 用于拉曼、反射和荧光光谱测量的集成光谱探头
US20170238807A9 (en) * 2013-03-15 2017-08-24 LX Medical, Inc. Tissue imaging and image guidance in luminal anatomic structures and body cavities
WO2014168734A1 (en) 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
US20140273181A1 (en) * 2013-03-15 2014-09-18 Biofire Diagnostics, Inc. Compact optical system for substantially simultaneous monitoring of samples in a sample array
US10362983B2 (en) * 2014-05-12 2019-07-30 Robert R. Alfano Near infrared photonic prostatoscopy analyzer
WO2017075176A1 (en) 2015-10-30 2017-05-04 Cedars-Sinai Medical Center Methods and systems for performing tissue classification using multi-channel tr-lifs and multivariate analysis
EP3436805A4 (en) 2016-04-01 2019-12-11 Black Light Surgical, Inc. SYSTEMS, DEVICES AND METHODS FOR TIME-RESOLUTION FLUORESCENCE SPECTROSCOPY
WO2017177194A1 (en) 2016-04-08 2017-10-12 Cedars-Sinai Medical Center Tissue classification method using time-resolved fluorescence spectroscopy and combination of monopolar and bipolar cortical and subcortical stimulator with time-resolved fluorescence spectroscopy

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11172826B2 (en) 2016-03-08 2021-11-16 Enspectra Health, Inc. Non-invasive detection of skin disease
US11877826B2 (en) 2016-03-08 2024-01-23 Enspectra Health, Inc. Non-invasive detection of skin disease
US11633149B2 (en) 2017-04-28 2023-04-25 Enspectra Health, Inc. Systems and methods for imaging and measurement of sarcomeres
US12285236B2 (en) 2018-11-13 2025-04-29 Enspectra Health, Inc. Methods and systems for generating depth profiles with improved optical resolution
US12514453B2 (en) 2023-08-02 2026-01-06 Enspectra Health, Inc. Non-invasive detection of skin disease

Also Published As

Publication number Publication date
CN108885173A (zh) 2018-11-23
US20200319108A1 (en) 2020-10-08
US20170284940A1 (en) 2017-10-05
US20250224335A1 (en) 2025-07-10
JP7266519B2 (ja) 2023-04-28
JP2022179782A (ja) 2022-12-02
JP7671725B2 (ja) 2025-05-02
EP3436805A1 (en) 2019-02-06
US11630061B2 (en) 2023-04-18
JP2019517006A (ja) 2019-06-20
WO2017173315A1 (en) 2017-10-05
JP2025065221A (ja) 2025-04-17
CA3019590A1 (en) 2017-10-05
US20220276167A1 (en) 2022-09-01
EP3436805A4 (en) 2019-12-11
US10656089B2 (en) 2020-05-19
CN115561211A (zh) 2023-01-03
US12025557B2 (en) 2024-07-02

Similar Documents

Publication Publication Date Title
JP7671725B2 (ja) 時間分解蛍光分光法のためのシステム、デバイス、および方法
JP5986670B2 (ja) マルチスペクトルフォトニック画像化方法及び装置
Loschenov et al. Photodynamic therapy and fluorescence diagnostics
US6580941B2 (en) Use of multiphoton excitation through optical fibers for fluorescence spectroscopy in conjunction with optical biopsy needles and endoscopes
KR102154547B1 (ko) 시간 분해 레이저 유기 형광 분광 시스템 및 그 용도
Moreira et al. Raman spectroscopy: A powerful technique for biochemical analysis and diagnosis
US20110042580A1 (en) Fluorescence quantification and image acquisition in highly turbid media
JP2022517422A (ja) 創傷および組織標本の３次元画像化、測定、および表示のためのシステム、方法、および装置
JP2011115658A (ja) 周辺光条件下のインビボ誘導信号の光学画像化
CN103608662A (zh) 肿瘤部位的识别装置以及识别方法
TW201737864A (zh) 使用時間分辨螢光光譜法以及單極和雙極皮質和皮質下刺激器與時間分辨螢光光譜法的組合的組織分類方法
US9820653B2 (en) Methods, systems, and devices for imaging microscopic tumors
Koizumi et al. Highly sensitive fluorescence detection of metastatic lymph nodes of gastric cancer with photo-oxidation of protoporphyrin IX
Lieber et al. Characterization of pediatric Wilms' tumor using Raman and fluorescence spectroscopies
Nishioka Laser-induced fluorescence spectroscopy
Baria et al. In vivo detection of murine glioblastoma through Raman and reflectance fiber-probe spectroscopies
Baria et al. In vivo multimodal fibre-probe spectroscopy for glioblastoma detection in mouse model
Vasefi et al. Autofluorescence-Guided Resection of Intracranial Tumor: Past, Present, and Future
Clary Raman spectroscopy for diagnosis of glioblastoma multiforme