TW201609163A - 口腔保健組成物 - Google Patents
口腔保健組成物 Download PDFInfo
- Publication number
- TW201609163A TW201609163A TW104136586A TW104136586A TW201609163A TW 201609163 A TW201609163 A TW 201609163A TW 104136586 A TW104136586 A TW 104136586A TW 104136586 A TW104136586 A TW 104136586A TW 201609163 A TW201609163 A TW 201609163A
- Authority
- TW
- Taiwan
- Prior art keywords
- zinc
- composition
- vermiculite
- abrasive
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 219
- 230000002087 whitening effect Effects 0.000 claims abstract description 34
- 210000003298 dental enamel Anatomy 0.000 claims abstract description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 85
- 239000010455 vermiculite Substances 0.000 claims description 67
- 229910052902 vermiculite Inorganic materials 0.000 claims description 67
- 235000019354 vermiculite Nutrition 0.000 claims description 67
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 49
- 239000011701 zinc Substances 0.000 claims description 49
- 229910052725 zinc Inorganic materials 0.000 claims description 49
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 32
- 238000010521 absorption reaction Methods 0.000 claims description 31
- 150000003752 zinc compounds Chemical class 0.000 claims description 27
- 239000000551 dentifrice Substances 0.000 claims description 24
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 22
- -1 desensitizers Substances 0.000 claims description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 20
- 230000036541 health Effects 0.000 claims description 12
- 239000011787 zinc oxide Substances 0.000 claims description 11
- 239000000853 adhesive Substances 0.000 claims description 10
- 230000001070 adhesive effect Effects 0.000 claims description 10
- 239000006260 foam Substances 0.000 claims description 10
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 9
- 239000011746 zinc citrate Substances 0.000 claims description 9
- 235000006076 zinc citrate Nutrition 0.000 claims description 9
- 229940068475 zinc citrate Drugs 0.000 claims description 9
- 238000005299 abrasion Methods 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 208000006558 Dental Calculus Diseases 0.000 claims description 7
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 7
- 239000011230 binding agent Substances 0.000 claims description 7
- 239000000796 flavoring agent Substances 0.000 claims description 7
- 239000007844 bleaching agent Substances 0.000 claims description 6
- 239000003086 colorant Substances 0.000 claims description 6
- 235000013355 food flavoring agent Nutrition 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 229940090898 Desensitizer Drugs 0.000 claims description 3
- 239000003599 detergent Substances 0.000 claims description 3
- 238000005728 strengthening Methods 0.000 claims description 3
- 229920001864 tannin Polymers 0.000 claims description 3
- 239000001648 tannin Substances 0.000 claims description 3
- 235000018553 tannin Nutrition 0.000 claims description 3
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 2
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 2
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 2
- MFGZXPGKKJMZIY-UHFFFAOYSA-N ethyl 5-amino-1-(4-sulfamoylphenyl)pyrazole-4-carboxylate Chemical compound NC1=C(C(=O)OCC)C=NN1C1=CC=C(S(N)(=O)=O)C=C1 MFGZXPGKKJMZIY-UHFFFAOYSA-N 0.000 claims description 2
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 claims description 2
- SOLUNJPVPZJLOM-UHFFFAOYSA-N trizinc;distiborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-][Sb]([O-])([O-])=O.[O-][Sb]([O-])([O-])=O SOLUNJPVPZJLOM-UHFFFAOYSA-N 0.000 claims description 2
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 claims description 2
- 239000004246 zinc acetate Substances 0.000 claims description 2
- 239000011667 zinc carbonate Substances 0.000 claims description 2
- 235000004416 zinc carbonate Nutrition 0.000 claims description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
- SRWMQSFFRFWREA-UHFFFAOYSA-M zinc formate Chemical compound [Zn+2].[O-]C=O SRWMQSFFRFWREA-UHFFFAOYSA-M 0.000 claims description 2
- 239000011670 zinc gluconate Substances 0.000 claims description 2
- 235000011478 zinc gluconate Nutrition 0.000 claims description 2
- 229960000306 zinc gluconate Drugs 0.000 claims description 2
- 239000011576 zinc lactate Substances 0.000 claims description 2
- 235000000193 zinc lactate Nutrition 0.000 claims description 2
- 229940050168 zinc lactate Drugs 0.000 claims description 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 2
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 2
- 229940032991 zinc picolinate Drugs 0.000 claims description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
- 229940118257 zinc undecylenate Drugs 0.000 claims description 2
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims description 2
- JNPQFTCBVDSMDO-UHFFFAOYSA-L zinc;2,3-dihydroxypropanoate Chemical compound [Zn+2].OCC(O)C([O-])=O.OCC(O)C([O-])=O JNPQFTCBVDSMDO-UHFFFAOYSA-L 0.000 claims description 2
- WDHVIZKSFZNHJB-UHFFFAOYSA-L zinc;butanoate Chemical compound [Zn+2].CCCC([O-])=O.CCCC([O-])=O WDHVIZKSFZNHJB-UHFFFAOYSA-L 0.000 claims description 2
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 claims description 2
- NHVUUBRKFZWXRN-UHFFFAOYSA-L zinc;pyridine-2-carboxylate Chemical compound C=1C=CC=NC=1C(=O)O[Zn]OC(=O)C1=CC=CC=N1 NHVUUBRKFZWXRN-UHFFFAOYSA-L 0.000 claims description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- FYHXNYLLNIKZMR-UHFFFAOYSA-N calcium;carbonic acid Chemical compound [Ca].OC(O)=O FYHXNYLLNIKZMR-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000005498 polishing Methods 0.000 claims 1
- 239000003082 abrasive agent Substances 0.000 abstract description 10
- 238000007517 polishing process Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 19
- 239000002002 slurry Substances 0.000 description 18
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 11
- 235000011941 Tilia x europaea Nutrition 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- DMGNFLJBACZMRM-UHFFFAOYSA-N O[P] Chemical compound O[P] DMGNFLJBACZMRM-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000004571 lime Substances 0.000 description 10
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000007407 health benefit Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 239000003002 pH adjusting agent Substances 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 210000003296 saliva Anatomy 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 208000025157 Oral disease Diseases 0.000 description 4
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000001680 brushing effect Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 208000002925 dental caries Diseases 0.000 description 4
- 229940091249 fluoride supplement Drugs 0.000 description 4
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 4
- 208000030194 mouth disease Diseases 0.000 description 4
- 208000028169 periodontal disease Diseases 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
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- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
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- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
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- 230000002265 prevention Effects 0.000 description 3
- 239000011775 sodium fluoride Substances 0.000 description 3
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- 229960000414 sodium fluoride Drugs 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 240000006927 Foeniculum vulgare Species 0.000 description 2
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
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- 229960002816 potassium chloride Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 229940093928 potassium nitrate Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229910052665 sodalite Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- DOJOZCIMYABYPO-UHFFFAOYSA-M sodium;3,4-dihydroxy-4-oxobutanoate Chemical compound [Na+].OC(=O)C(O)CC([O-])=O DOJOZCIMYABYPO-UHFFFAOYSA-M 0.000 description 1
- JZVZOOVZQIIUGY-UHFFFAOYSA-M sodium;tridecanoate Chemical compound [Na+].CCCCCCCCCCCCC([O-])=O JZVZOOVZQIIUGY-UHFFFAOYSA-M 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- MCOGTQGPHPAUJN-UHFFFAOYSA-L zinc;2-hydroxyacetate Chemical compound [Zn+2].OCC([O-])=O.OCC([O-])=O MCOGTQGPHPAUJN-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/087270 WO2014100928A1 (en) | 2012-12-24 | 2012-12-24 | Oral care composition |
Publications (1)
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|---|---|
| TW201609163A true TW201609163A (zh) | 2016-03-16 |
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| TW104136586A TW201609163A (zh) | 2012-12-24 | 2013-12-19 | 口腔保健組成物 |
| TW102147094A TWI558418B (zh) | 2012-12-24 | 2013-12-19 | 口腔保健組成物 |
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| TW102147094A TWI558418B (zh) | 2012-12-24 | 2013-12-19 | 口腔保健組成物 |
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| JP (1) | JP2016503036A (enExample) |
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| CN (1) | CN104981273B (enExample) |
| AR (1) | AR094208A1 (enExample) |
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| BR (1) | BR112015015260A2 (enExample) |
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| IL (1) | IL239533A0 (enExample) |
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| PH (1) | PH12015501260A1 (enExample) |
| RU (1) | RU2636221C2 (enExample) |
| TW (2) | TW201609163A (enExample) |
| WO (1) | WO2014100928A1 (enExample) |
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| CN104721063B (zh) * | 2013-12-19 | 2018-05-08 | 高露洁-棕榄公司 | 包含氧化锌和柠檬酸锌的洁齿剂组合物 |
| US11400032B2 (en) | 2013-12-20 | 2022-08-02 | Colgate-Palmolive Company | Tooth whitening oral care product with core shell silica particles |
| BR112016013531A8 (pt) | 2013-12-20 | 2020-05-19 | Colgate Palmolive Co | composição de cuidado oral |
| MX368518B (es) * | 2014-08-08 | 2019-10-07 | Colgate Palmolive Co | Prevencion y remocion de manchas dentales. |
| AR102640A1 (es) | 2014-11-14 | 2017-03-15 | Colgate Palmolive Co | Composición para cuidado bucal que contiene sales de zinc y carbonato de calcio |
| US11026871B2 (en) * | 2015-10-08 | 2021-06-08 | Colgate-Palmolive Company | Oral care compositions and methods of using the compositions |
| WO2017079962A1 (en) * | 2015-11-13 | 2017-05-18 | The Procter & Gamble Company | Dentifrice compositions with anti-tartar and anti-bacterial benefits |
| BR112018009205B1 (pt) * | 2015-11-13 | 2021-06-01 | The Procter & Gamble Company | Composições dentifrícias com estabilidade melhorada de fluoreto |
| BR112018009609B1 (pt) | 2015-11-13 | 2021-03-16 | The Procter & Gamble Company | composições dentifrícias com absorção melhorada de fluoreto |
| BR112018007793B1 (pt) | 2015-11-13 | 2021-06-22 | The Procter & Gamble Company | Composições dentifrícias com estabilidade melhorada de fluoreto |
| EP3373892B1 (en) | 2015-11-13 | 2021-04-28 | The Procter & Gamble Company | Dentifrice compositions with dual fluoride source with improved fluoride uptake |
| EP3436155B1 (en) | 2016-03-31 | 2021-10-13 | Unilever Global IP Limited | Toothpaste composition |
| US11826447B2 (en) | 2016-05-10 | 2023-11-28 | Colgate-Palmolive Company | Alginate dentifrice compositions and methods of making thereof |
| CA3024162A1 (en) | 2016-06-24 | 2017-12-28 | Colgate-Palmolive Company | Oral care composition comprising zingerone and bisabolol and methods of use |
| CN107969115B (zh) * | 2016-06-24 | 2021-12-24 | 高露洁-棕榄公司 | 口腔护理组合物及使用方法 |
| AU2017280072B2 (en) * | 2016-06-24 | 2019-11-14 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| WO2018118161A1 (en) | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| CA3053879C (en) * | 2017-03-03 | 2021-12-07 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| BR112019019843B1 (pt) * | 2017-04-27 | 2022-12-13 | Unilever Ip Holdings B.V. | Composição de cuidados orais, método para beneficiar os dentes de um indivíduo e uso de uma composição de cuidados orais |
| JP7126811B2 (ja) * | 2017-07-25 | 2022-08-29 | 株式会社ジーシー | 歯面清掃用組成物 |
| GB201811065D0 (en) * | 2018-07-05 | 2018-08-22 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Novel composition |
| AU2019401224B2 (en) * | 2018-12-20 | 2022-09-15 | Colgate-Palmolive Company | Oral care compositions |
| CA3123251A1 (en) * | 2018-12-26 | 2020-07-02 | Colgate-Palmolive Company | Prebiotic role of arginine on beneficial oral bacteria |
| EP3946219A1 (en) * | 2019-05-06 | 2022-02-09 | Colgate-Palmolive Company | Oral care compositions |
| AU2020337430B2 (en) * | 2019-08-27 | 2023-11-02 | Colgate-Palmolive Company | Zinc phosphate containing compositions |
| US20220378678A1 (en) * | 2021-05-26 | 2022-12-01 | Colgate-Palmolive Company | Oral Care Compositions |
| CN118252768A (zh) * | 2022-12-28 | 2024-06-28 | 高露洁-棕榄公司 | 多色口腔护理组合物和用于其的方法 |
| WO2025031754A1 (en) * | 2023-08-10 | 2025-02-13 | Unilever Ip Holdings B.V. | Oral care composition |
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| US6703066B1 (en) | 1992-07-10 | 2004-03-09 | Robert R. Holcomb | Flavor enhancer composition containing colloidal silica and method for its preparation and use |
| FI104044B1 (fi) | 1995-07-28 | 1999-11-15 | Tapio Hurme | Hampaiden hoidossa käytettävä valmiste |
| US6503483B2 (en) | 1997-06-12 | 2003-01-07 | C.S. Bioscience, Inc. | Dental formulation |
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| JP3854540B2 (ja) | 2002-05-29 | 2006-12-06 | 新キャタピラー三菱株式会社 | シリンダ装置および履帯式車両 |
| US20040101494A1 (en) | 2002-11-26 | 2004-05-27 | Scott Douglas Craig | Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth |
| EP1773279B1 (en) * | 2004-08-03 | 2015-09-02 | Unilever N.V. | Toothpaste comprising calcium carbonate and zinc citrate |
| WO2006050777A1 (en) * | 2004-11-15 | 2006-05-18 | Unilever N.V. | Toothpaste composition |
| CA2634758A1 (en) * | 2005-12-20 | 2007-07-05 | The Procter & Gamble Company | Oral care compositions comprising zinc and phytate |
| JP5657206B2 (ja) | 2005-12-21 | 2015-01-21 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 清浄及び／又は光沢組成物とその使用の方法 |
| WO2008006725A1 (en) | 2006-07-13 | 2008-01-17 | Unilever Plc | Toothpaste composition |
| US20110229534A1 (en) | 2006-10-05 | 2011-09-22 | The Trustees Of Columbia University In The City Of New York | Non-Irritating Oral Care Formulations |
| WO2008157033A1 (en) | 2007-06-20 | 2008-12-24 | Mcneil-Ppc, Inc | Products for whitening teeth |
| RU2471475C2 (ru) * | 2008-02-08 | 2013-01-10 | Колгейт-Палмолив Компани | Продукт для ухода за полостью рта и способы его применения и получения |
| JP5600346B2 (ja) * | 2009-05-26 | 2014-10-01 | コルゲート・パーモリブ・カンパニー | 歯磨剤組成物 |
| JP5495626B2 (ja) | 2009-06-04 | 2014-05-21 | 花王株式会社 | 歯磨剤 |
| US9446267B2 (en) | 2009-10-06 | 2016-09-20 | Symrise Ag | Products comprising a flavoring agent composition |
| JP2013520402A (ja) * | 2010-01-29 | 2013-06-06 | コルゲート・パーモリブ・カンパニー | 敏感なエナメル質のケアのための口腔ケア製品 |
| BR112012017707B1 (pt) | 2010-01-29 | 2021-11-09 | Colgate-Palmolive Company | Composição para higiene oral para cuidado do esmalte sensível |
| CN102811698B (zh) | 2010-03-31 | 2016-01-13 | 高露洁-棕榄公司 | 口腔护理组合物 |
| CN102218021B (zh) | 2010-04-15 | 2013-01-23 | 刘钦 | 一种除口臭、预防口腔溃疡的牙膏 |
| CN103079526A (zh) | 2010-09-10 | 2013-05-01 | 荷兰联合利华有限公司 | 有益于牙齿的口腔护理组合物 |
| WO2012031785A2 (en) | 2010-09-10 | 2012-03-15 | Unilever Plc | Composite particle active and method for making the same |
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| WO2012171738A1 (en) | 2011-06-17 | 2012-12-20 | Unilever N.V. | An oral care composition |
| CN102283794B (zh) * | 2011-08-22 | 2013-07-24 | 昆明振华制药厂有限公司 | 一种含有三七和蜂胶的牙膏及其制备方法 |
| CN102283795A (zh) * | 2011-08-22 | 2011-12-21 | 昆明振华制药厂有限公司 | 一种蜂胶牙膏及其制备方法 |
| CN102512349B (zh) * | 2012-01-10 | 2013-07-10 | 广州薇美姿个人护理用品有限公司 | 益早益晚清火组合牙膏和益晚清火牙膏 |
| CN102512335B (zh) * | 2012-01-10 | 2013-07-17 | 广州薇美姿个人护理用品有限公司 | 一种益晚美白牙膏和一种益早益晚美白的组合牙膏 |
| BR112015012959B1 (pt) * | 2012-12-06 | 2018-12-11 | Colgate-Palmolive Company | composição para cuidado oral |
-
2012
- 2012-12-24 CA CA2892557A patent/CA2892557C/en active Active
- 2012-12-24 JP JP2015548143A patent/JP2016503036A/ja active Pending
- 2012-12-24 WO PCT/CN2012/087270 patent/WO2014100928A1/en not_active Ceased
- 2012-12-24 US US14/654,511 patent/US10064794B2/en active Active
- 2012-12-24 RU RU2015124686A patent/RU2636221C2/ru active
- 2012-12-24 MX MX2015008279A patent/MX354227B/es active IP Right Grant
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- 2012-12-24 BR BR112015015260A patent/BR112015015260A2/pt not_active IP Right Cessation
- 2012-12-24 CN CN201280077975.3A patent/CN104981273B/zh not_active Expired - Fee Related
- 2012-12-24 KR KR1020157019518A patent/KR20150100785A/ko not_active Withdrawn
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2013
- 2013-12-19 AR ARP130104942A patent/AR094208A1/es unknown
- 2013-12-19 TW TW104136586A patent/TW201609163A/zh unknown
- 2013-12-19 TW TW102147094A patent/TWI558418B/zh not_active IP Right Cessation
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2015
- 2015-06-03 PH PH12015501260A patent/PH12015501260A1/en unknown
- 2015-06-18 IL IL239533A patent/IL239533A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104981273B (zh) | 2018-03-13 |
| EP2934693B1 (en) | 2018-02-14 |
| IL239533A0 (en) | 2015-08-31 |
| RU2015124686A (ru) | 2017-01-30 |
| US10064794B2 (en) | 2018-09-04 |
| BR112015015260A2 (pt) | 2017-07-11 |
| CN104981273A (zh) | 2015-10-14 |
| EP2934693A1 (en) | 2015-10-28 |
| AU2012398397A1 (en) | 2015-06-18 |
| CA2892557A1 (en) | 2014-07-03 |
| AR094208A1 (es) | 2015-07-15 |
| JP2016503036A (ja) | 2016-02-01 |
| TWI558418B (zh) | 2016-11-21 |
| TW201440795A (zh) | 2014-11-01 |
| WO2014100928A1 (en) | 2014-07-03 |
| RU2636221C2 (ru) | 2017-11-21 |
| MX2015008279A (es) | 2015-09-29 |
| KR20150100785A (ko) | 2015-09-02 |
| AU2012398397B2 (en) | 2015-11-26 |
| WO2014100928A8 (en) | 2015-06-25 |
| CA2892557C (en) | 2020-09-15 |
| AU2012398397A8 (en) | 2015-07-02 |
| MX354227B (es) | 2018-02-19 |
| EP2934693B2 (en) | 2021-10-27 |
| US20150328094A1 (en) | 2015-11-19 |
| PH12015501260A1 (en) | 2015-08-17 |
| EP2934693A4 (en) | 2016-09-14 |
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