TW201546076A - 新穎氮雜苯并咪唑衍生物 - Google Patents
新穎氮雜苯并咪唑衍生物 Download PDFInfo
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- TW201546076A TW201546076A TW103124425A TW103124425A TW201546076A TW 201546076 A TW201546076 A TW 201546076A TW 103124425 A TW103124425 A TW 103124425A TW 103124425 A TW103124425 A TW 103124425A TW 201546076 A TW201546076 A TW 201546076A
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- alkyl
- pyridin
- phenyl
- furan
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- -1 C 5-7 -cycloalkenyl Chemical group 0.000 claims description 92
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 74
- 229910052731 fluorine Inorganic materials 0.000 claims description 49
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 41
- 125000001072 heteroaryl group Chemical group 0.000 claims description 36
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 29
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 28
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- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 15
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 12
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 12
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- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
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Landscapes
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| EP3180338B1 (en) * | 2014-08-11 | 2018-05-09 | Boehringer Ingelheim International GmbH | Azabenzimidazole derivatives as amp protein kinase agonistes |
| AU2015309863B2 (en) | 2014-08-27 | 2019-12-05 | Shionogi & Co., Ltd. | Azaindole derivative having AMPK-activating effect |
| KR20170077131A (ko) | 2014-10-28 | 2017-07-05 | 시오노기세야쿠 가부시키가이샤 | Ampk 활성화 작용을 갖는 복소환 유도체 |
| JP6612881B2 (ja) * | 2015-01-16 | 2019-11-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なアザベンゾイミダゾール誘導体 |
| JPWO2017146186A1 (ja) | 2016-02-26 | 2018-12-20 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有する５−フェニルアザインドール誘導体 |
| CN109476661A (zh) * | 2016-05-20 | 2019-03-15 | 盐野义制药株式会社 | 具有ampk活化作用的5-取代苯并咪唑及5-取代氮杂苯并咪唑衍生物 |
| WO2020080979A1 (en) * | 2018-10-15 | 2020-04-23 | Gero Discovery Limited Liability Company | Pfkfb3 inhibitors and their uses |
| UY38941A (es) | 2019-11-11 | 2021-06-30 | Pi Industries Ltd | Nuevas sulfiliminas o sulfoximinas que contienen compuestos heterocíclicos fungicidas |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| AU2024222719A1 (en) | 2023-02-16 | 2025-08-21 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
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| WO2012033149A1 (ja) | 2010-09-10 | 2012-03-15 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するヘテロ環縮合イミダゾール誘導体 |
| PH12013501686A1 (en) * | 2011-02-25 | 2017-10-25 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| RU2015109706A (ru) * | 2012-08-22 | 2016-10-10 | Мерк Шарп И Доум Корп. | Новые производные азабензимидазол гексагидрофуро[3, 2-в]фурана |
| WO2014031468A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole hexahydrofuro[3,2-b]furan derivatives |
| WO2014069426A1 (ja) * | 2012-10-31 | 2014-05-08 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するベンズイミダゾールおよびアザベンズイミダゾール誘導体 |
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| EA201600113A1 (ru) | 2016-07-29 |
| US9492436B2 (en) | 2016-11-15 |
| TR201806860T4 (tr) | 2018-06-21 |
| JP2016527223A (ja) | 2016-09-08 |
| CA2918401A1 (en) | 2015-01-22 |
| PH12016500092B1 (en) | 2019-04-12 |
| KR20160033749A (ko) | 2016-03-28 |
| PL3022210T3 (pl) | 2018-08-31 |
| AU2014292236B2 (en) | 2018-11-08 |
| WO2015007669A1 (en) | 2015-01-22 |
| EP3022210B1 (en) | 2018-02-21 |
| MX2016000547A (es) | 2016-04-20 |
| US20150025065A1 (en) | 2015-01-22 |
| EP3022210A1 (en) | 2016-05-25 |
| HUE038261T2 (hu) | 2018-10-29 |
| CN105377857B (zh) | 2018-04-10 |
| AR096936A1 (es) | 2016-02-10 |
| EA032195B1 (ru) | 2019-04-30 |
| JP6491656B2 (ja) | 2019-03-27 |
| UY35668A (es) | 2015-01-30 |
| PH12016500092A1 (en) | 2016-04-18 |
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