TW201404779A - 新的雜芳基和雜環化合物、其組合物及方法 - Google Patents

新的雜芳基和雜環化合物、其組合物及方法 Download PDF

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TW201404779A
TW201404779A TW102127033A TW102127033A TW201404779A TW 201404779 A TW201404779 A TW 201404779A TW 102127033 A TW102127033 A TW 102127033A TW 102127033 A TW102127033 A TW 102127033A TW 201404779 A TW201404779 A TW 201404779A
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Wei-Guo Su
Guang-Xiu Dai
Kun Xiao
Hong Jia
zhu-lin Zhang
Jennifer Diane Venable
Scott Damian Bembenek
Wenying Chai
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Hutchison Medipharma Ltd
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
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  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW102127033A 2012-07-27 2013-07-26 新的雜芳基和雜環化合物、其組合物及方法 TW201404779A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2012/079290 WO2014015523A1 (en) 2012-07-27 2012-07-27 Novel heteroaryl and heterocycle compounds, compositions and methods
PCT/CN2013/072686 WO2014015675A1 (en) 2012-07-27 2013-03-15 Novel heteroaryl and heterocycle compounds, compositions and methods

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TW201404779A true TW201404779A (zh) 2014-02-01

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TW102127033A TW201404779A (zh) 2012-07-27 2013-07-26 新的雜芳基和雜環化合物、其組合物及方法

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US (2) US20150291593A1 (cg-RX-API-DMAC7.html)
EP (1) EP2877472A4 (cg-RX-API-DMAC7.html)
JP (1) JP5976933B2 (cg-RX-API-DMAC7.html)
KR (1) KR20150036738A (cg-RX-API-DMAC7.html)
AU (1) AU2013295906B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015001695A2 (cg-RX-API-DMAC7.html)
CA (1) CA2880251C (cg-RX-API-DMAC7.html)
EA (1) EA201590281A1 (cg-RX-API-DMAC7.html)
IN (1) IN2015DN00827A (cg-RX-API-DMAC7.html)
MX (1) MX2015001207A (cg-RX-API-DMAC7.html)
TW (1) TW201404779A (cg-RX-API-DMAC7.html)
WO (3) WO2014015523A1 (cg-RX-API-DMAC7.html)

Cited By (1)

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CN107690433A (zh) * 2015-06-18 2018-02-13 韩国化学研究院 杂芳基衍生物或其药学上可接受的盐、其制备方法以及包含其作为活性成分的用于预防或治疗pi3激酶相关疾病的药物组合物

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JP2016512239A (ja) 2013-03-15 2016-04-25 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物
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