TW201245225A - Antibody polypeptides that antagonize CD40 - Google Patents

Antibody polypeptides that antagonize CD40 Download PDF

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Publication number
TW201245225A
TW201245225A TW101114258A TW101114258A TW201245225A TW 201245225 A TW201245225 A TW 201245225A TW 101114258 A TW101114258 A TW 101114258A TW 101114258 A TW101114258 A TW 101114258A TW 201245225 A TW201245225 A TW 201245225A
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Taiwan
Prior art keywords
seq
bms3h
gly
ser
leu
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TW101114258A
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English (en)
Inventor
Anish Suri
Steven Sheriff
Suzanne Suchard
Aaron Yamniuk
Stanley Krystek
James Tamura
James Bryson
Steven Grant
Philip Drew
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Bristol Myers Squibb Co
Domantis Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46000407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW201245225(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co, Domantis Ltd filed Critical Bristol Myers Squibb Co
Publication of TW201245225A publication Critical patent/TW201245225A/zh

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Description

201245225 六、發明說明： 【發明所屬之技術領域】 本發明提供靶向CI)40且不展現CD40促效劑活性之抗體 及其片段、包含前述者之組合物及使用前述者治療涉及 CD40活性之疾病的方法。 序列表 本申請案含有ASCII格式之序列表且其據此以全文引用 的方式併入本文中。2012年4月17日創建之該ASCII複本被 ^ 命名為200896WO.txt且大小為1，188,530位元組。 【先前技術】 CD40為屬於存在於抗原呈現細胞（antigen presenting cell，APC)(包括樹突狀細胞、B細胞及巨噬細胞）上之腫瘤 壞死因子（tumor necrosis factor，TNF)受體超家族之協同 刺激分子。八？(：在€〇40結合丁}1細胞上之其配位體€〇154 (CD40L)時活化。CD40介導之APC活化涉及多種免疫反 應，包括細胞激素產生、協同刺激分子（諸如CD86)之上調 • 及抗原呈現及B細胞增殖增強。CD40亦可由内皮細胞、平 滑肌細胞、纖維母細胞及上皮細胞表現。 CD40活化亦涉及多種與例如自體免疫性、移植排斥反 應或過敏反應相關之不當T細胞反應。控制不合乎需要之T 細胞反應的一個策略為以拮抗性抗體靶向CD40。舉例而 言，先前稱為Chiron 1212之單株抗體HCD122(魯卡木單抗 (Lucatumumab))有關治療某些CD40介導之發炎性疾病目前 處於臨床試驗階段=參見網際網路之超文字傳送協定： 163920.doc 201245225 clinicaltrialsfeeds.org/clinical-trials/show/NCTO 1275209 (2011年1月11日最後更新）上之「Study of HCD122 (Lucatumumab) and Bendamustine Combination Therapy in CD40+ Rituximab-Refractory Follicular Lymphoma」， Clinical Trials Feeds。然而，單株抗體可顯示促效劑活 性。舉例而言，抗CD40抗體Chi220之適用性受限於其弱 刺激潛能。參見 Adams等人，「Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival」，《/. 174: 542-50 (2005)。 【發明内容】 在臨床環境中仍需要不具有部分促效劑活性之抗CD40 抗體拮抗劑。本發明提供特異性結合人類CD40之新穎抗 原決定基之新穎抗體多肽。如由競爭分析及由自抗體多肽 與CD40共結晶得到之結構所示，CD40抗原決定基不與 Chi220抗原決定基重疊。該等抗體多肽有利的是不展現 CD40促效劑活性。該等抗體多肽適用於治療涉及CD40活 化之疾病，包括自體免疫疾病、移植排斥反應及過敏反 應。該等抗體多肽包含可變域。在一個實施例中，抗體多 肽呈含有單一可變域之域抗體（dAb)形式。在另一個實施 例中，dAb為包含可結合例如人類血清白蛋白（HSA)之第 二可變域之雙特異性試劑。 本發明提供一種包含第一可變域之抗體多肽，其中該抗 體多肽特異性結合人類CD40之抗原決定基，其中該抗原 163920.doc 201245225 決定基包含SEQ ID ΚΌ: 1之胺基酸序列，其中該抗體多肽 與域抗體（dAb) BMS3h_56_269 (SEQ ID NO: 417)競爭結 合，且其中該抗原決定基包含至少一個選自由Trpl09、 Leul21、Hisl22、Serl24、Serl56、Alal57、Phel58、 Glul59及Hisl62組成之群的CD40胺基酸殘基。 進一步提供一種抗體多肽，其中第一可變域包含選自由 BMS3h-37、BMS3h-38、BMS3h-56及 BMS3h-198 組成之系 群的抗體多肽之一之胺基酸序列，且其中第一可變域之表 觀結合常數為1 pM至100 nM。進一步提供一種抗體多肽， 其中第一可變域之表觀結合常數為1 pM至10 nM。 亦提供一種抗體多肽，其中第一可變域之胺基酸序列包 含（a)與 BMS3h-56-269 (SEQ ID NO: 417)之 CDR1區有至多 兩個胺基酸不同的CDR1區、（b)與BMS3h-56-269 (SEQ ID NO: 417)之CDR2區有至多兩個胺基酸不同的CDR2區、（c) 與 BMS3h-56-269 (SEQ ID NO; 417)之 CDR3 區有至多兩個 胺基酸不同的 CDR3 區、（d)與BMS3h-56-269 (SEQ ID NO: 417)之FR1區有至步兩個胺基酸不同的FR1區、（e)與 BMS3h-56-269 (SEQ ID NO: 417)之FR2區有至多兩個胺基 酸不同的 FR2 區 ' (f)與 BMS3h-56-269 (SEQ ID NO: 417)之 FR3區有至多兩個胺基酸不同的fr3區及（g)與6"8311-56-269 (SEQ ID NO: 417)之FR4區有至多兩個胺基酸不同的 FR4 區。 亦提供一種抗體多肽’其中第一可變域之胺基酸序列包 含⑷與BMS3h-56-269 (SEQ ID NO: 417)之CDR1區有至多 163920.doc 201245225 兩個胺基酸不同的CDR1區、（b)與BMS3h-56-269 (SEQ ID NO: 417)之CDR2區有至多兩個胺基酸不同的CDR2區、（c) 與 BMS3h-56-269 (SEQ ID NO: 417)之 CDR3區有至多兩個 胺基酸不同的CDR3區。 進一步提供一種抗體多肽’其中第一可變域之胺基酸序 列與 BMS3h_56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 4I7)之胺基酸序列有至多ι〇個胺基酸不同β 進一步提供一種抗體多肽’其中第一可變域之胺基酸序 列與 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列有至多5個胺基酸不同。 進一步提供一種抗體多肽，其中第一可變域之胺基酸序 列與 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列有兩個胺基酸不同》 進一步提供一種抗體多肽，其中第一可變域之胺基酸序 列與 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO:417)之胺基酸序列有一個胺基酸不同。 進一步提供一種抗體多肽，其中該抗體多肽係選自 BMS3h-5 6之系群’且其中第一可變域之胺基酸序列進一 步包含：（a)具有序列 Xi-Tyr-Glu-Y^Trp (SEQ ID NO: 1274)之 CDR1區，其中X^Asp 或 Gly，且Y!為 Met 或 Leu; (b)具有序列 Ala-Ile-Asn-Pro-X2-Gly-Y2-Z2_Thr-Tyr-Tyr-Ala-Asp-Ser-Val-A2-Gly(SEQ ID NO: 1275)之CDR2區，其 中 X2 為 Gin、Tyr、Pro、Trp 或 Ala，Y2 為 Thr、Ser、Asn、
Gly、Met或 Gin，Z2 為 Arg、Leu、Tyr、His 或 Phe，且八2為 163920.doc -6 - 201245225
Lys 或 Met ;及（c)具有序列 X3-Pro-Y3-Z3-Phe-A3-B3 (SEQ ID NO: 1276)之 CDR3 區，其中 χ3 為 Leu 或 Pro，Y3 為 Phe、 Gin、Thr 或 Met ’ Z3 為 Tyr、Pro、Leu、Thr、lie、Phe 或 Met，A〗為 Gin、His、Asp、Ser、Lys、Glu或 Gly，且 B3為 Glu、Asp 或 Tyr。
進一步提供一種抗體多肽，其中第一可變域之胺基酸序 列包含：（a)具有序列0111-\^1-0111-1^11-1^11-0111-861>017-Gly-Gly--Leu-Val-Gln.-Pro-Gly-Gly-Ser-Xi - Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe_Y1 (SEQ ID NO: 1277)之 FR1區，其中X丨為Leu或Arg，且丫丨為入^或Ala; (b)具有序 列 Trp-Val-Arg-X2-Ala-Pro-Gly-Y2-Z2-Leu-Glu-Arg-Val-Ser (SEQ ID NO: 1278)之 FR2 區，其中 X2 為 Gin 或 Arg，Y2為 Lys 或 Arg，且 Ζ2為 Gly 或 Val; (c)具有序列入巧-?1^-1'11]>116-Ser-Arg-Asp-Asn-Ser-Lys-Asn-X3-Lys-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Y3-Asp-Thr-Z3-Val-Tyr-A3-Cys-B3-Lys (SEQ ID NO: 1279)之 FR3區，其中X3 為 Thr 或 Met，Y3 為 Glu或 Asp，Z3為 Ala或 Ser，A3為 Tyr 或 His，且 B3 為 Ala或 Thr ;及（d)具有序列又4-〇1丫-丫4-01丫-1'11卜1^11-乂&1-1'11卜¥&1-Ser-Z4 (SEQ ID NO: 1280)之FR4 區，其中 X4為 Trp或 Arg， Y4 為 Gin 或 Pro，且 Z4 為 Ser 或 Asn。 進一步提供一種抗體多肽，其中第一可變域包含 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列。 進一步提供一種坑體多肽，其中該抗體多肽係選自 163920.doc 201245225 BMS3h-37之系群，其中第一可變域包含序列〇111-¥丑1-01|1-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Xi-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Glu-Trp-Tyr-Glu-Met-Gln-Trp-Val-Arg-Arg-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser-Ala-Ile-Ser-Gly-Asp-Gly-Tyr-Arg-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Tyr-Cys-Ala-Ly s-Y i-Leu-Zi-Ai-Phe-Asp-Tyr-Bi-Gly-Arg-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (SEQ ID NO: 1281);且其中又1為 Gin 或 Arg ; YAGlu 或 Gly ; ZeAla、Leu 或 Glu ; A,為 Phe 或 Tyr;且 Bi 為 Trp或 Arg。 亦提供一種抗體多肽，其中該抗體多肽係選自BMS3h-38之系群，其中第一可變域包含序列Glu-Val-Gln-Leu-Leu-Ala-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Xi-Phe-Glu-Glu-Glu-Glu-Met-Ile-Trp-Val-Arg-Gin-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser-Yi-Ile-Ser-Zj-Ai-Gly-Bj-Ci-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-A sp-Asn-Ser-Ly s-Asn-Thr-L eu-Tyr-Leu-Gin-Met-Asn-Ser-Leu_Arg-Ala_Glu-Asp_Thr_Ala-'Val_Tyr-Tyr-Cys-Gly-Lys-Glu-Pro-Phe-Di-Tyr-Asp-Tyr-Trp-Gly-Gln-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (SEQ ID NO: 1282);且其中 X^Thr或 Pro ; 或Ser ; Z〗為Arg或Gly ;八1為人^、Ser、 163920.doc 201245225
Asn、Gin、Gly、Hi!;或 Leu ; 81為丁丫1·、Phe、Trp 或 Gly ; (^為 Ser 或 Gly ;且 D丨為 Arg、Met 或 Pro。
亦提供一種抗體多肽，其中該抗體多肽係選自BMS3h-198之系群，其中第一可變域包含序列Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Ala-Gly-Try-Glu-X^Trp-Trp-Y^Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Arg-Val-Ser-Ala-Ile-Ser-Gly-Ser-Gly-Gly-Ser-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Z^A^Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Bi-Cys-Ala-C,-D,-Pro-Tyr-Ser-Ei-Asp-Tyr-Fi-G^Hj-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (SEQ ID NO: 1283);且其中 ΧΘ Met或 Leu ; YA Val 或 Phe ; ZAAsp 或 Asn ; A^Ser 或 Thr ; B!為 Tyr 或 His ; C1為Lys或Arg;D1為Asp或Glu;E1為Tyr或Phe;F1為Trp 或 Arg; G^Gly 或 Aig;且 H丨為 Gin 或 His。 進一步提供一種抗體多肽’其中該抗體多肽為域抗體 (dAb)。 進一步提供一種抗體多肽’其中可變域融合至Fc域。 進一步提供一種抗體多肽’其中該抗體多肽進一步包含 特異性結合第二抗原之第二可變域，其中該第二抗原為除 人類CD40以外之抗原。 亦提供一種抗體多肽，其中第二抗原為分化簇（cluster of differentiation，CD)分子或主要組織相容性複合體 163920.doc • 9- 201245225 (Major Histocompatibility Complex，MHC) II類分子。 亦提供一種抗體多肽，其中第二抗原為血清白蛋白 (SA)。 本發明提供一種編碼本文所揭示之抗體多肽的核酸。 本發明亦提供一種包含本文所揭示之核酸的載體。 本發明亦提供一種包含本文所揭示之載體的宿主細胞。 本發明提供一種包含治療有效量之本文所揭示之抗體多 肽及醫藥學上可接受之載劑的醫藥組合物。本發明亦提供 一種進一步包含免疫抑制/免疫調節劑及/或消炎劑之醫藥 組合物。 本發明提供一種治療需要該治療之患者的免疫疾病之方 法’其包含向該患者投與治療有效量之本文所揭示之醫藥 組合物。本發明亦提供一種方法’其中該醫藥組合物與免 疫抑制/免疫調節劑及/或消炎劑組合投與。 本發明提供一種治療免疫疾病之方法，其中該免疫疾病 為自體免疫疾病或移植相關疾病。本發明進一步提供一種 治療免疫疾病之方法’其中該免疫疾病係選自由以下組成 之群：艾迪森氏病（Addison’s disease)、過敏症、僵直性脊 椎炎、哮喘、動脈粥樣硬化、自體免疫性耳病、自體免疫 性眼病、自體免疫肝炎、自體免疫腮腺炎、結腸炎、冠心 病、克羅恩氏病（Crohn's disease)、糖尿病（包括1型及/或2 型糖尿病）、附睪炎、絲球體腎炎、葛瑞夫兹氏病（Graves， disease)、格-巴二氏徵候群（Guillain-Barre syndrome)、橋 本氏病（Hashimoto's disease)、溶血性貧血、特發性血小板 163920.doc •10· 201245225 減少性紫癜、發炎性腸病、對重組藥品之免疫反應、全身 性紅斑狼瘡、男性不育症、多發性硬化症、重症肌無力、 天疱瘡、牛皮癖、風濕熱、類風濕性關節炎、類肉瘤病、 硬皮病、休格連氏症候群（Sjogren's syndrome)、脊椎關節 病、曱狀腺炎、移植排斥反應、血管炎、AIDS、異位性 過敏症、支氣管哮喘、濕疹、麻風病、精神分裂症、遺傳 性抑鬱症、組織及器官之移植、慢性疲勞症候群、阿茲海 默氏病（Alzheimer's disease)、帕金森氏病（Parkinson's disease)、心肌梗塞 '中風、自閉症、癲癇症、阿瑟氏現 象（Arthus’s phenomenon)、全身性過敏反應、酒精成瘾及 藥物成癮。 本發明亦提供一種使用特異性結合包含SEQ ID NO: 1之 胺基酸序列的人類CD40之抗原決定基的第一可變域靶向 CD40之方法，其中抗體多肽與域抗體（dAb)BMS3h-56-269 (SEQ ID NO: 417)競爭結合。 本發明提供抗體多肽或其醫藥學上可接受之鹽的醫學用 途，該抗體多肽包含特異性結合包含SEQ ID NO: 1之胺基 酸序列的人類CD40之抗原決定基的第一可變域，其中該 抗體多肽與域抗體（dAb) BMS3h-56-201 (SEQ ID NO: 9)競 爭結合。 本發明提供抗體多肽或其醫藥學上可接受之鹽的用途， 該抗體多肽包含特異性結合包含SEQ ID NO: 1之胺基酸序 列的人類CD40之抗原決定基的第一可變域，其中該抗體 多肽與域抗體（dAb) BMS3h-5 6-201 (SEQ ID NO: 9)競爭結 163920.doc 201245225 合，該用途係用於製備用以治療免疫疾病之藥劑。在一些 實施例中，醫藥組合物與免疫抑制/免疫調節劑及/或消炎 劑組合投與。在其他實施例中，免疫疾病為自體免疫疾病 或移植相關疾病。在其他實施例中’該免疫疾病係選自由 以下組成之群：艾迪森氏病、過敏症、僵直性脊椎炎、哮 喘、動脈粥樣硬化、自體免疫性耳病、自體免疫性眼病、 自體免疫肝炎、自體免疫腮腺炎、結腸炎、冠心病、克羅 恩氏病、糖尿病（包括1型及/或2型糖尿病）、附睪炎、絲球 體腎炎、葛瑞夫茲氏病、格-巴二氏徵候群、橋本氏病、 溶血性貧血、特發性血小板減少性紫癜、發炎性腸病、對 重組藥品之免疫反應、全身性紅斑狼瘡、男性不育症、多 發性硬化症、重症肌無力、天疱瘡、牛皮癬、風濕熱、類 風濕性關節炎、類肉瘤病、硬皮病、休格連氏症候群、脊 椎關節病、甲狀腺炎、移植排斥反應、血管炎、AIDS、 異位性過敏症、支氣管哮喘、濕疹、麻風病、精神分裂 症、遺傳性抑鬱症、組織及器官之移植、慢性疲勞症候 群、阿茲海默氏病、帕金森氏病、心肌梗塞、中風、自閉 症、癲癇症、阿瑟氏現象、全身性過敏反應、酒精成癮及 藥物成瘾》 本發明提供一種抗體多肽或其醫藥學上可接受之鹽，該 抗體多狀包含特異性結合包含Seq id NO: 1之胺基酸序列 的人類CD40之抗原決定基的第一可變域，其中該抗體多 肽與域抗體（dAb) BMS3h-56-201 (SEQ ID NO: 9)競爭結 合’該抗體多狀或其醫藥學上可接受之鹽係用於製備用以 163920.doc -12· 201245225 治療免疫疾病之藥劑。該藥劑可例如與免疫抑制/免疫調 節劑及/或消炎劑組合投與。免疫疾病可為例如自體免疫 疾病或移植相關疾病。免疫疾病亦可選自由以下組成之 群：艾迪森氏病、過敏症、僵直性脊椎炎、哮喘、動脈粥 樣硬化、自體免疫性耳病、自體免疫性眼病、自體免疫肝 炎、自體免疫瓜腺炎、結腸炎、冠心病、克羅恩氏病、糖 尿病（包括1型及/或2型糖尿病）、附睪炎、絲球體腎炎、葛 瑞夫茲氏病、格-巴二氏徵候群、橋本氏病、溶血性貧 金、特發性血小板減少性紫癜、發炎性腸病、對重組藥品 之免疫反應、全身性紅斑狼瘡、男性不育症、多發性硬化 症、重症肌無力、天疱瘡、牛皮癬、風濕熱、類風濕性關 節炎、類肉瘤病、硬皮病、休格連氏症候群、脊椎關節 病、甲狀腺炎、移植排斥反應、血管炎、aids、異位性 過敏症、支氣管哮喘、濕疹、麻風病、精神分裂症、遺傳 性抑鬱症、組織及器官之移植、慢性疲勞症候群、阿兹海 默氏病、帕金森氏病、心肌梗塞、中風、自閉症、癲痛 症、阿瑟氏現象、全身性過敏反應、酒精成癮及藥物成 癮0 【實施方式】 專利或申請案檔案含有至少一個彩製圖式。在申請且支 付必要的費用後’專利局將提供具有彩色圖式之本專利或 專利申請公開案之複本。 本發明提供特異性結合至人類CD40之抗體多肽。該等 抗體多肽不展現CD40促效劑活性，且該等抗體多肽適用 163920.doc 13 201245225 於治療涉及CD40活化之疾病，諸如自體免疫疾病《該等 抗體多肽可使用利用細胞結合分析之初步篩檢，隨後進行 一或多輪易錯或簡併寡核苷酸定向親和力成熟來選擇。結 果，提供一類特異性結合單一 CD40抗原決定基之抗體多 肽。 「譜系」為如以下實例中所揭示由常見前驅體藉由易錯 或簡併寡核苷酸定向親和力成熟而製備且預期結合相同 CD40抗原決定基之一組相關抗體多肽。使用抗體多肽之 命名表示各種譜系。舉例而言，命名「BMS3h-56」係指 針對人類CD40所產生之譜系56之抗體多肽。「譜系BMS3h-56」抗體多肽包括BMS3h-56-l直至BMS3h-56-33及 BMS3h-56-202直至 BMS3h-56-288。 因此，在一個態樣中，抗體多肽包含特異性結合人類 CD40之可變域，其中該抗體多肽與表3中所列之任一域抗 體（dAb)競爭結合。舉例而言，dAb可能屬於選自由以下組 成之群的譜系：例如BMS3h-3 7、BMS3h-3 8、BMS3h-41、 BMS3h-43、BMS3h-56、BMS3h-131、BMS3h-198 及 BMS3h-202，諸如 dAb BMS3h-56-5、BMS3h-56-201 或 BMS3h-56-258。在另一個態樣中，抗體多肽特異性結合與表3中所列 之任一 dAb相同之人類CD40抗原決定基。舉例而言，抗體 多肽可包含特異性結合與例如dAb BMS3h-56-5、BMS3h-56-201或BMS3h-56-258相同之人類CD40抗原決定基的可 變域。如下文所揭示，人類CD40抗原決定基可包含例如 SEQ ID NO: 1之胺基酸殘基Trpl09。 163920.doc • 14- 201245225 抗體多肽可為含有單一可變域之域抗體 。抗體多肽亦可 包含其他結構域，諸如卜域。舉例而言，抗體多肽可包含 特異性結合人類血清白蛋白（HSA)之第二可變❺。舉例而 。該等雙特異性抗體多肽可具有增加之半衰期。 在序列表中，SEQ ID NO: 1為人類CD40之胺基酸序 列，SEQ ID NO: 2為長尾獼猴CD4〇之胺基酸序列。域抗體 BMS3h-56-5之胺基酸序列為SEQ m N〇: 321。 如本文所用’「特異性結合」係指抗體多肽結合抗原之 • 解離常數(Kd)如例如藉由表面電漿子共振所量琪J，為約1 μΜ或1 μΜ以下。適當分析系統包括BIAc〇reTM表面電漿子 共振系統及力學評估軟體（例如21版）。特異 性結合相互作用之親和力或Kd可為約5〇〇 nM或500 nM以 下或約300 nM或300 :nM以下。 術語「約」將為一般熟習此項技術者所瞭解且在使用其 之情形下將有一定程度之變化。一般而言，約涵蓋加上/ 減去提及值之10%的數值範圍。 •根據此實施方式，以下縮寫及定義適用。須注意，除非 本文另外明確規定’否則如本文所用，單數形式「一 (a)」、「一（an)」及「該」包括複數個指示物。因此，舉例 而言’提及「抗體」包括複數個該等抗體，且提及「劑 量」包括提及一或多個為熟習此項技術者所知之劑量及其 等同量等。 1. CD40及 CD40活性 提供結合人類CD40之抗體多狀。CD40亦稱為Β細胞表 163920.doc •15- 201245225 面抗原 CD40、Bp50、CD40L受體、CDw40、CDW40、 MGC9013、p50、TNFRSF5及腫瘤壞死因子受體超家族成 員5。人類CD40之相關結構資訊可例如以UniProt寄存編號 P25942、Q9BYU0及Q53GN5找到。「人類CD40」係指包含 以下胺基酸序列之CD40 :
MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDWCGPQD RLRALVVIPI IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ (SEQIDNO：l)〇 亦已在小家鼠（Mms wmscm/m·?)、野猪（Sw·? jcro/ia)、歐洲牛 長尾獼狼（食蟹獼狼）、綿羊ar/ei)、家馬 及褐家鼠（Λαίίι/·? 中對 CD40測序。 本發明抗體多肽與CD40之結合拮抗CD40活性。「CD40 活性」包括（但不限於）T細胞活化（例如誘導T細胞增殖或 細胞激素分泌）、巨嗟細胞活化（例如誘生巨嗟細胞中之活 性氧物質及氧化氮）及B細胞活化（例如B細胞增殖、抗體同 型轉換或分化成漿細胞）。CD40活性可藉由與其他分子相 互作用來介導。「CD40活性」包括CD40與以下分子之間的 功能相互作用，該等分子以其Uniprot寄存編號於括號内標 識： CALR (P27797)； ERP44 (Q9BS26); 163920.doc -16 - 201245225 FBL (P22087)； POLR2H (P52434)； RFC5 (P40937)； SGK1 (000141)； SLC30A7 (Q8NEW0)； SLC39A7 (Q92504)； TRAF2 (Q5T1L5)； TRAF3 (Q13114)； TRAF6 (Q9Y4K3)； TXN (Q5T937)； UGGT1 (Q9NYU2);及 USP15 (Q9Y4E8)。 舉例而言，CD40「活性」包括與TRAF2之相互作用》 CD40/TRAF2相互作用活化NF-κΒ及JNK。參見Davies等 人，Mo/. Ce// 价〇/. 25: 9806-19 (2005)。因此，此CD40活 性可利用CD40依賴性細胞NF-κΒ及JNK活化相對於參照組 來測定。 如本文所用，術語 「活化（activate)」、「活化 (activates)」及「活化（activated)」係指既定可量測CD40 活性相對於參照組增加至少10%，例如至少10%、25%、 50%、75%或甚至100%或100%以上。若活性相對於不存在 拮抗劑之情況降低至少10%，且在一個例示性實施例中降 低至少約 20%、30%、40%、50%、60%、70%、80%、 90%、95%、97%或甚至100% (亦即無可偵測活性），則 163920.doc -17- 201245225 CD40活性被「拮抗」。舉例而言，抗體多肽可拮抗一些或 所有CD40活性，而不活化CD40。在一個實施例中，抗體 多肽不活化B細胞增殖。在另一個實施例中，抗體多肽不 活化T細胞之細胞激素分泌，其中細胞激素為至少一種選 自由以下組成之群的細胞激素：11^-2、11^-6、11^-10、11^-13、TNF-α、IFN-γ。 2. CD40抗原決定基 使用人類 CD40 (SEQ ID NO: 1)與 dAb BMS3h-56-5 (SEQ ID NO: 321)之間的複合物之X射線結晶學來揭示由本發明 之抗體多肽所識別之抗原決定基。針對電子密度資料擬合 CD40及BMS3h-56-5之結構模型以產生七種模型或型式之 CD40/BMS3h-56-5複合物，其來自三種呈一種晶形之結晶 學獨立複合物及四種呈第二晶形之結晶學獨立複合物。該 等型式之主鍵原子之真實空間相關係數（real space correlation coefficient)為約0.92且側鏈原子之真實空間相 關係數為0.80。在七種型式中CD40分子具有一定量之可撓 性，但所有型式中均保留CD40/BMS3h-56-5相互作用之總 體性質。該等型式在CD40殘基Trpl09與BMS3h-56-5 Trpl03(Kabat編號，參見下文）之間的相互作用不同。 BMS3h-56-Trpl03與一種型式之CD40 Trpl09形成邊對面相 互作用，而與其他型式形成置換堆疊（亦即面對面）相互作 用。 七種型式之形狀互補性統計值Sc在0.70至0.77之範圍 内，此顯示與典型抗體抗原複合物相比形狀互補性之程度 163920.doc -18· 201245225 較高。舉例而言，此等值可與四種蛋白酶/蛋白質抑制劑 複合物之0.71至0.76之範圍、五種寡聚界面之0.70至0.74之 範圍及六種抗體/抗原複合物之0.64至0.68之範圍比較。參 見 Lawrence 等人，「Shape Complementarity at Protein/ Protein Interfaces」，乂 Μσ/· 5ζ·ο/· 234: 946-950 (1993) °
圖1中顯示人類CD40/BMS3H-56-5複合物模型。一個 BMS3h-56-5 dAb 結合於一個 CD40 分子。BMS3h-56-5 抗原 決定基不與Chi220 Fab'片段抗原決定基重疊。所有型式之 複合物界定一組接觸BMS3h-56-5之CD40殘基：Trpl09、 Leul21、Hisl22、Serl24、Serl56、Alal57、Phel58、 0111159及出8162(參考8丑(^1〇]^0:1)。一些型式之複合物 中接觸 BMS3h-56-5 之 CD40 殘基為 Pro85、Asn86、Leu87、 Gly88、Glul06、G:iul07、Glyl08、HisllO、Thrll2、 Cysll9、Vall20、Glnl33、Ilel34、Alal35、Thrl36、 Seri55及Lys 160。在所有型式中Vail 54為内埋CD40殘基。 在一些型式中内埋之其他CD40殘基為Serll8、Argl23、 Thrl41 、 Phel51 、 Aspl53 、 Cysl61及Prol63 。 如本文所用，術語「接觸」係指原子間距離，其最大值 決定於如 Sheriff等人，·/· Μο/· 5^/. 197: 273-296 (1987)及 Sheriff, 心 3: 191-196 (1993)所定義之原子型 距離依賴性。 如本文所用，術語「内埋」係指一殘基具有至少一個具 有由程式MS (Connolly, J. OpiaZ/ogr. 16: 548-558 (1983))所定義之表面積、1.7A之探針球及如Sheriff， 163920.doc •19· 201245225
Immunomethods 3 : 191 -196 (1993)所定義之原子型依賴性 凡得瓦爾半徑（Van der Waals radii)的原子。 圖2顯示包括接觸殘基及内埋殘基之BMS3h-56-5 (SEQ ID NO: 321)之表面。CD40 (SEQ ID NO: 1)表示為帶狀 圖，橙色表示非重複二級結構且洋紅色表示抗原決定基殘 基。在各種非人類靈長類動物序列中所顯示之CD40殘基 Trpl09、Alall5、Leul21、Serl26 及 Hisl62不同。CD40 殘 基入比115及861*126位於61^8311-56-5結合位點之對側。 Trpl09及 Leul21在位於 BMS3h-56-5 之 CDR3 與 FR-2 (殘基 Leu45及Arg47)之間的間隙中結合。Hisl62與BMS3h-56-5 之CDR2中之殘基，尤其Lys 56相互作用。總之，CD40抗 原決定基包含一或多個表1中所列之殘基，參考SEQ ID NO: 1中所用之編號。 表1 接觸BMS3h-56-5之CD40殘基：
Trpl09、Leul2卜 Hisl22、Serl24、Serl56、
Alal57、Phel58、Glul59、Hisl62_ BMS3h-56-5，如表3中所列之其他dAb，係使用人類 CD40作為抗原藉由下文更詳細描述之篩檢及親和力成熟 方法來製備。預期由常見前驅dAb藉由親和力成熟產生之 dAb將結合相同人類CD40抗原決定基。舉例而言，下文所 述之競爭研究指示由常見前驅dAb藉由親和力成熟產生之 dAb彼此競爭結合於人類CD40。然而，相同競爭研究顯示 dAb不與至少Chi220或G28-5抗體競爭。 3.抗體多肽 163920.doc -20- 201245225 抗體多肽包含可變域。在一個實施例中，抗體多肽呈含 有單一可變域之dAb形式。抗體多肽可為包含藉由雙硫鍵 互連之兩個重（H)鏈及兩個輕（L)鏈之全長抗CD40免疫球蛋 白分子。在此實施例中，各鏈之胺基末端部分包括主要經 由其中所含之互補決定區（CDR)負責抗原識別的約100至 110個胺基酸之可變域（VL或VH)。各重鏈之羧基末端「半 部」界定主要負責效應功能之恆定區（Fc)。 抗體多肽亦可為包含含特異性結合CD40之可變域的全 長抗CD40免疫球蛋白分子之一部分的「片段」。因此，術 語「抗體多肽」包括例如抗原結合重鏈、輕鏈、重鍵-輕 鏈二聚體、Fab片段、F(ab')2片段、Fv片段、單鏈Fv (scFv)及dAb »因此’術語「抗體多肽」包括藉由重組工 程改造及表現而產生之多肽，以及藉由天然重組及融合瘤 細胞純系分泌所產生之單株抗體。 輕鏈係分類為κ或λ，且如此項技術中所知其特徵在於特 定恆定區Cl。重鏈係分類為γ、μ、α、δ或ε，且將抗體之 同型分別定義為IgG、IgM、IgA、IgD或IgE。對於IgG、 IgD及IgA，重鏈恆定區包含三個結構域（CHI、CH2及 CH3);且對於IgM及IgE，包含四個結構域（CHI、CH2、 CH3及CH4P抗CD40抗體可具有選自任一免疫球蛋白類 別（IgA、IgD、IgG、IgM及IgE)之重鏈恆·定區。 各輕鏈可變域（VL)及重鏈可變域（VH)由三個CDR及四個 構架區（FR)構成，自胺基末端至羧基末端按以下順序排 列：FR1、CDR1、FR2、CDR2、FR3、CDR3、FR4。輕鏈 之三個CDR被稱為「LCDR1、LCDR2及LCDR3」，且重鏈 163920.doc •21- 201245225 之三個CDR被稱為「HCDR1、HCDR2及HCDR3」。 如本文所用，術語「Fc域」係指包含CH2及CH3恆定域 之值定區抗體序列，如Kabat等人，〇/ Immunological Interest，第5版，美國健康與人類服務部 (U.S. Dept. Health & Human Services), Washington, D.C. (1991)所界定。Fc區可源自例如IgGl或IgG4 Fc區。可變域 可融合至Fc域。在此情況下，可變域（VL或VH域，包括 dAb)之羧基末端可連接或融合至Fc CH2域之胺基末端。或 者，可變域之羧基末端可連接或融合至CH1域之胺基末 端，CH1域之胺基末端本身融合至Fc CH2域。蛋白質可包 含CH1與CH2域之間的鉸鏈區整體或部分。 CDR含有大部分與抗原形成特異性相互作用之殘基。如 圖2中所示，例如CDR2及CDR3加上FR4殘基Trpl03形成 CD40與dAb BMS3h-56-5之間的大部分接觸。舉例而言， 抗體多肽之可變域包含具有與表3中所列之dAb之一的 CDR1、CDR2及CDR3區相同之胺基酸序列或各與CDR1、 CDR2及CDR3區有一或兩個胺基酸不同之CDR1、CDR2及 CDR3區。舉例而言，抗體多肽可包含具有與例如BMS3h-56-5、BMS3h-56-258 或 BMS3h-56-201 之 CDR1、CDR2 及 CDR3區相同之胺基酸序列的CDR1、CDR2及CDR3區。
「域抗體」（dAb)包含能夠特異性及單價結合抗原（諸如 CD40)之單一可變（VL或VH)域。舉例而言，dAb可具有駱 駝科動物dAb所特有之VHH結構。如本文所用，「VH域」意 謂包括VHH結構。在另一個實施例中，本發明之VH域（包括 作為本文之實施例呈現的所有特徵及特徵之組合）不為VHH 163920.doc -22· 201245225 域。dAb可在溶液中形成均二聚體或雜二聚體。咸信二價 抗CD40抗體由於能夠交聯結合細胞表面上之CD40分子而 展現促效劑活性。儘管不受任何特定理論限制，但咸信單 價dAb不活化CD40，因為該等dAb不與CD40交聯。 如本文所用，術語「可變域」係指由Kabat等人， Sequences of Immunological Interest，％ 5版，矣風後藤與 人類服務部，Washington，D.C. (1991)所定義之免疫球蛋 白可變域。可變域内CDR胺基酸殘基之編號及定位係根據 熟知Kabat編號約定確定。舉例而言，在表2中比較 BMS3h-56-5 (SEQ II) NO: 321)之Kabat編號與依序編號之 相同序列。在Kabat編號中，BMS3h-56-5具有插入殘基 52A、82A、82B、82C，且殘基100。在兩種編號系統中， 給予作為表現構築體之一部分的N端之Ser及Thr負編號。 表2 _CDR2_ — Kabat "60 70 80 90 — A - I - I - I ABC - I -順序 <;0 70 80 90 100 I - I - I - I - 1 BMS3h-56-5 INPQGTRTYyADSVMGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLP CDR3 Kabat Ϊ01 110 116 I - I -I 順序 1:.0 119 ~ - I BMS3h-56-5 FTFDDWGQG^?LVTVSSAAA (SEQ ID NO: 3) -2-1
II
BMS3h-56-5 ST CDR1 • Kabat 10 - 1 - 20 1 30 1 - 40 1 - 50 1 順序 10 20 30 40 50
BMS3h-56-5 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSA •23- 163920.doc 201245225 術語「人類」在應用於抗體多肽時意謂抗體多肽具有源 自人類免疫球蛋白之序列’例如FR及/或〇11域。當序列 係：（a)自人類個體或自人類個體之細胞或細胞株分離而 得；（b)自經選殖之人類抗體基因序列或人類抗體可變域序 列之文庫分離而得；或（c)藉由自一或多個以上多肽突變及 選擇而多樣化時，該序列係「源自」人類免疫球蛋白編碼 序列。如本文所用，「經分離」之化合物意謂該化合物已 與在自然界中與該化合物天然締合之至少一種組分分離。 可將抗體多肽投與人類患者，同時基本上避免通常藉由 投與來自其他物種（例如小鼠）之抗體而引起的抗抗體免疫 反應。舉例而言，鼠類抗體可根據此項技術中熟知之程序 藉由將鼠類CDR移植於人類可變域FR上而「人類化」《然 而’如本文所揭示之人類抗體可在不需要鼠類抗體序列之 基因操控之情況下產生。 可變域可包含一或多個具有與由人類生殖系抗體基因區 段編碼之相應構架區相同之胺基酸序列的構架區（FR)。舉 例而言’域抗體可包含VH生殖系基因區段DP47、DP45或 DP38、VK生殖系基因區段DPK9、JH區段JH4b或JK區段 JK1。 可改變抗體多肽序列，同時保留特異性結合CD40之能 力。特定言之，抗體多肽（例如dAb)可包含保留特異性結 合與dAb BMS3h-56-5相同之CD40抗原決定基的功能之變 異型可變域。參見表1。亦即，變異型可變域可結合包含 SEQ ID NO: 1 之 Trpl09、Leul21、Hisl22、Serl24、 163920.doc -24- 201245225
Serl56、Alal57 ' Phel58、Glul59 及 Hisl62 中之至少一者 的人類CD40抗原決定基。在一個實施例中，變異型可變 域抗原決定基可包含 Trpl09、Leul21、Hisl22、Serl24、 Serl56、Alal57、Phel58、Glul59 及 Hisl62。或者，變異 型可變域可特異性結合包含CD40殘基Trpl09之CD40抗原 決定基❶在又一個實施例中，變異型可變域可與BMS3h-56-5競爭特異性結合於CD40。如以下實例中所揭示，易錯 親和力成熟提供一種製造及鑑別具有特異性結合相同 CD40抗原決定基之變異型序列的抗體多肽之例示性方 法。 舉例而言，變異型可變域與表3中所列之可變域之一可 有至多10個或其間之任何整數值個胺基酸不同，其中該變 異型可變域特異性結合CD40。或者，變異型可變域相對 於本發明序列表中所列之序列可具有至少90%序列一致性 (例如至少92%、95%或98°/。序列一致性）。在兩個序列之間 不同的非一致胺基酸殘基或胺基酸可表示胺基酸取代、添 加或缺失。當兩個序列藉由諸如BLAST之任何適當胺基酸 序列比對演算法比對時，在兩個序列之間不同之殘基以非 一致位置呈現。 其限制條件為可對個別FR區進行胺基酸取代，以便一或 多個FR相對於由人類生殖系抗體基因區段編碼之相應Fr 之胺基酸序列包含至多兩個胺基酸差異。其限制條件進一 步為變異型可變域在一或多個CDR中可含有一或兩個胺基 酸取代。特異性結合CD40之代表性可變域列於表3中》 163920.doc -25· 201245225 來自譜系 BMS3h-56、BMS3h-37、BMS3h-38 及 BMS3h-198之抗體多肽之代表性可變域之間的ciustalW2比對分別 示於圖4、圖5、圖6及圖7中。通常，相關蛋白質序列之比 對中胺基酸之保守程度與胺基酸位置對蛋白質功能之相對 重要性成比例。亦即，所有相關序列中共有之胺基酸可能 起重要作用且不能輕易被取代。另一方面，序列之間不同 的位置可能經其他胺基酸取代或以其他方式修飾，同時維 持蛋白質之活性。示於圖4、圖5、圆6及圖7中之比對以及 例如由圖1及圖2確定之結構關係可引導特異性結合包含 SEQ ID NO: 1之胺基酸序列的人類CD40之抗原決定基的變 異型抗體多肽之建構，其中該抗體多肽與(1八匕8]^8311-56-201 (SEQ ID NO: 9)競爭結合。該等變異型抗體多肽包括 (但不限於）具有對應於關於表3中所列之任一可變域的取 代、插入或缺失之胺基酸修飾的變異型抗體多肽。變異型 抗體多狀亦包括具有對應於表3中所列序列之間保守之胺 基酸修飾的胺基酸修飾之變異型抗體多狀。 關於重鏈及輕键基因之VL或VH域之邊界的資訊可用於 汉s十PCR引子以擴增來自編碼已知結合cd4〇之抗體多肽的 經選殖之重鏈或輕鏈編碼序列之可變域。使用此項技術中 熟知之技術，可將擴增之可變域插入適當表現載體（例如 pHEN-1) (Hoogenboom等人，（1991) Nucleic Acids Res. 19:4133-4137)中且使其單獨地或以與另一多肽序列之融合 物形式表現。基於所揭示之胺基酸及聚核苷酸序列，可產 生融合蛋白且僅使用普通技術於任何適當哺乳動物宿主細 163920.doc -26· 201245225 胞株（諸如CHO、293、COS、NSO及其類似細胞株）中來純 化，隨後使用一種方法或方法之組合來純化，該等方法包 括蛋白質A親和層析法、離子交換法、逆相技術或其類似 方法。 在一個態樣中，抗體多肽為包含特異性結合包含SEQ m Ν〇. 1之胺基酸序列的人類CD40之第一可變域的「雙特異 性」抗體多肽。雙特異性抗體多肽包含特異性結合除人類 CD40以外之第二抗原之第二可變域。 在另一個實施例中，第二抗原可為例如免疫效應細胞之 細胞表面分子或可溶性分子（諸如細胞激素）。雙特異性抗 體多肽之結合可用於拮抗CD4〇且拮抗第二抗原之生物活 性。免疫效應細胞之細胞表面分子包括分化簇（CD)分子。 代表性CD標記列於網際網路之超文字傳送協定 en.wikipedia.org/wiki/List_of_human_clusters_of .differentiation 上（2012年2月22日進行最後修改）。免疫效應細胞之細胞表 面分子亦包括主要組織相容性複合體（MHC) II類分子。針 對此等細胞表面分子之抗體在此項技術中為已知的且可作 為可變域來源用於構築雙特異性抗體多肽。 在一個實施例中，雙特異性配位體之抗體多肽可藉由 「胺基酸連接子」或「連接子」連接。舉例而言，dAb可 融合至胺基酸連接子之N端，且另—dAb可融合至連接子 之C端。儘管胺基酸連接子可為任何長度且由胺基酸之任 何組合組成’但連接子長度可能相對較短（例如五個或五 個以下胺基酸）以降低所連接結構域之間的相互作用。亦 163920.doc -27- 201245225 可調節連接子之胺基酸組成以減少具有龐大側鏈之胺基酸 或可能引入二級結構中之胺基酸的數目。適當胺基酸連接 子包括（但不限於）長度為至多3、4、5、6、7、10、15、20 或25個胺基酸之胺基酸連接子。代表性胺基酸連接子序列 包括（GGGGS)n (SEQ ID NO: 4)，其中η可為1與5之間的任 何整數。其他適當連接子序列可選自由以下組成之群：
AST (SEQ ID NO: 5)、TVAAPS (SEQ ID NO: 6)、TVA (SEQ ID NO: 7)及 ASTSGPS (SEQ ID NO: 8)。 第二抗原之結合可增加抗體多肽之活體内半衰期。舉例 鲁 而言，雙特異性抗體多肽之第二可變域可特異性結合血清 白蛋白（SA)，例如人類血清白蛋白（HSA)。經形式設計而 可結合HSA之抗體多肽相對於相同的未經形式設計之抗體 多肽可具有增加之活體内t-α (「α半衰期」）或t-β (「β半衰 期」）半衰期。t-α及t-β半衰期量度物質分佈於身體内且自 身體内消除有多快。舉例而言，鍵聯至HSA可藉由抗體多 肽與能夠特異性結合HS A之第二可變域之融合來實現。抗 人類血清白蛋白抗體在此項技術中為熟知的。參見例如在 籲 網際網路之超文字傳送協定www.abcam.con^index.html上 可獲知之Abeam® :人類血清白蛋白抗體ab 10241、ab2406 及ab8940 ，或在網際網路之超文字傳送協定 www.genwaybio.com上可獲知之GenWay ALB抗體》特異性 結合HSA之可變域可獲自任一此等抗體，且接著使用此項 技術中熟知之重組技術融合至本發明之抗體多肽。 或者，抗體多肽連接至HSA可藉由使用熟練技術者熟知 163920.doc -28- 201245225 之技術使抗體多肽序列直接稠合至H S A編碼序列來實現。 hsa編碼序列可藉由PCR使用源自例如可以GenBank寄存 編號NM000477獲得之cDNA序列之引子來獲得。 在一個實施例中，經HSA連接之域抗體組合物之仏半衰 期增加10%或1〇Q/0以上。在另一個實施例中，經hsa連接 之域抗體組合物之ta半衰期在〇.25小時至6小時之範圍内。 在另一個實施例中，經HSA連接之域抗體組合物之邙半衰 期增加10%或1〇。/0以上。在另一個實施例中，經HSA連接 • 之域抗體組合物之邙半衰期在12小時至48小時之範圍内。 在另一個實施例中，可藉由聚乙二醇化對抗體多肽進行 形式設計以增加其活體内半衰期。在一個實施例中，將 PEG共價連接。在另一個實施例中，將PEG連接至抗體多 狀之半脱胺酸或離胺酸殘基。在又一個實施例中，經peg 連接之抗體多肽之流體動力學尺寸為至少24 kDe在又一 個實施例中，總PEG尺寸為20kDi6〇kD且包括2〇kD&6〇 kD。在又—個實施例中，經pEG連接之域抗體之流體動力 •學尺寸為至少2〇〇 kD。 聚乙二醇化可使用若干PEG連接部分達成，該等pE(J連 接部分包括（但不限於）N_羥基丁二醯亞胺活性酯、丙酸丁 醯亞胺ga、順丁稀二酿亞胺、乙浠礙或硫醇。PEG聚合 物可連接至抗體多肽之預定位置，或可任意地連接至域抗 體刀子。聚乙二醇化亦可經由連接至域抗體之肽連接子介 導。亦即’ PEG部分可連接至融合至抗體多肽之狀連接 子’其中該連接子提供用於PEG連接之位點（例如游離半胱 163920.doc -29- 201245225 胺酸或離胺酸）。聚乙二醇化抗體之方法在此項技術中熟 知，例如如 Chapman 等人，「PEGy’lated antibodies and antibody fragments for improved therapy: a review」，
Drwg DWzv. 54(4):531-45 (2002)中所揭示。 抗體多肽亦可經設計以形成二聚體、三聚體、四聚體或 其他多聚體。抗體多肽（例如dAb)可藉由此項技術中已知 之若干方法（包括（但不限於）以融合蛋白形式表現單體 '兩 個或兩個以上單體經由單體之間的肽連接子鍵聯）、或藉 由在轉譯之後彼此直接或藉由雙硫鍵經由連接子以化學方 式接合單體、或藉由鍵聯至二價、三價或多價連接部分 (例如多臂PEG)來連接以形成多聚醴。在一個實施例中， 多聚體可結合單一 CD40分子》 4.醫藥組合物及治療方法 醫藥組合物包含治療有效量之一或多種抗體多肽及視情 況選用之醫藥學上可接受之載劑。醫藥學上可接受之載劑 包括例如水、生理食鹽水、磷酸鹽緩衝鹽水、右旋糖、甘 油、乙醇及其類似物以及其組合。醫藥學上可接受之載劑 可進一步包含極少量之可增加融合蛋白之儲存期限或效用 之助劑物質’諸如濕潤劑或乳化劑、防腐劑或緩衝劑。組 合物可經調配以在投與之後提供活性成分之快速、持續或 延遲釋放。適當醫藥組合物及其製備方法在此項技術中為 熟知的。參見例如 Remjngt〇n，The Science and Practice of
Pharmacy，A，Gennaro 等人編，第 21 版 ’ Mack Publishing
Co. (2005)。 163920.doc •30- 201245225 醫藥組合物進一步可包含免疫抑制/免疫調節劑及/或消 炎劑。治療需要該治療之患者的免疫疾病之方法可包含向 患者投與治療有效量之醫藥組合物。拮抗CD40介導之丁細 胞活化可抑制例如自體免疫性 '移植排斥反應或過敏反應 期間發生之不當T細胞反應。抑制CD40介導之τ細胞活化 可減緩此等疾病之進展及/或嚴重程度。 如本文所用，「患者」意謂動物，例如哺乳動物，包括 人類。患者可經診斷患有免疫疾病。「治療（Treatment)」 或「治療（treat)」或「治療（treating)」係指涉及減輕症 狀、病症、病狀或疾病之進展或嚴重程度之方法。「免疫 疾病」係指與個體中顯現免疫反應，包括細胞及/或體液 免疫反應相關之任何疾病。免疫疾病之實例包括（但不限 於）發炎、過敏症、：自體免疫疾病或移植相關疾病。自體 免疫疾病可選自由全身性紅斑狼瘡、多發性硬化症、類風 濕性關節炎、糖尿病、牛皮癬、硬皮病、動脈粥樣硬化、 發炎性腸病及潰瘍性結腸炎組成之群。 可藉由投與醫藥組合物治療之疾病可選自由以下組成之 群.艾迪森氏病、過敏症、僵直性脊椎炎、哮喘、動脈粥 樣硬化、自體免疫性耳病、自體免疫性眼病、自體免疫肝 炎、自體免疫腮腺炎、結腸炎、冠心病、克羅恩氏病、糖 尿病（包括1型及/或2型糖尿病）、附睪炎、絲球體腎炎、葛 瑞夫茲氏病、格-巴二氏徵候群、橋本氏病、溶血性貧 血、特發性血小板減少性紫癜、發炎性腸病、對重組藥品 之免疫反應（例如血犮病患者中之因子VII)、全身性紅斑狼 163920.doc -31- 201245225 瘡'男性不育症、多發性硬化症、重症肌無力、天疱瘡、 牛皮癬、風濕熱、類風濕性關節炎、類肉瘤病、硬皮病、 休格連氏症候群、脊椎關節病、曱狀腺炎、移植排斥反應 及血管炎。自體免疫介導之病狀包括（但不限於）受影響之 組織為主要目標，且在一些情況下為次要目標之病狀。該 等病狀包括（但不限於）AIDS、異位性過敏症、支氣管哮 喘、濕疹、麻風病、精神分裂症、遺傳性抑鬱症、組織及 器官之移植、慢性疲勞症候群、阿茲海默氏病、帕金森氏 病、心肌梗塞、中風、自閉症、癲癇症、阿瑟氏現象、全 身性過敏反應、酒精成癮及藥物成瘾。 醫藥組合物可單獨或以與免疫抑制/免疫調節劑及/或消 炎劑之組合療法投與（亦即同時或依序）^不同免疫疾病可 能需要使用適用於治療免疫疾病之特定助劑化合物，此可 根據患者對患者之基準來確定。舉例而言，醫藥組合物可 與一或多種例如細胞激素（例如IL_1()及IL_13)或其他免疫 刺激劑（例如趨化因子、腫瘤相關抗原及肽）之適當佐劑組 合投與。適當佐劑在此項技術中為已知的。 可使用任何適當方法或途徑來投與抗體多肽或醫藥組合 物。投藥途徑包括例如經口、靜脈内、腹膜内、皮下或肌 肉内投與。投與之抗體多肽之治療有效劑量視許多因素而 定’包括例如所治療之免疫疾病之類型及嚴重程度、組合 療法之用途'抗體多肽或醫藥組合物之投藥途徑及患者之 體重。域抗體之治療有效量之非限制性範圍相對於患者之 體重為0.1 mg/kg至20 mg/kg，且在一個態樣中，為j 163920.doc -32· 201245225 mg/kg至10 mg/kg ^在疾病病況之活體外及/或活體内模型 中’抗體多肽之劑量可由為CD40拮抗作用所需之抗體多 狀之量進一步引導。代表性模型描述於下文及實例中。 5.活體外及活體内模型 可在若干可獲得之活體外或活體内模型系統中之一者中 測試本發明之抗體多肽拮抗CD40之能力。適當動物及細 胞模型系統描述於下文。其他細胞分析系統描述於實例 中〇 5·1·發炎性腸病（IBD)模型： IBD為不明病因之多因性免疫病症。類似IBD之若干黏 膜發炎小鼠模型提供了有關控制正常與病理性黏膜免疫功 能之機制的理解。IE1D模型包括使用De Winter等人， 乂 276: G1317-1321 (1999)之黏膜免疫及發炎系 統。在一個態樣中，將CD4(+) T淋巴細胞之子集（亦即 CD4(+) CD45RBhighM胞）注射至免疫缺陷小鼠中會引起腸 發炎。發病機理部分係歸因於促炎性細胞因子之分泌。結 腸炎之誘發可藉由共轉移另一 CD4 (+)亞群（亦即CD4(+) CD45RBlow T細胞）來預防。就獲取活化標記及返回宿主 腸而言，此群體之行為類似於CD4(+) CD45RBhigh群體。 然而，活化時其淋巴介質概況不同，且CD4(+) CD45RBlow T細胞分泌及/或誘導之消炎細胞激素會預防 結腸炎。De Winter等人提供有關過繼性轉移模型及促進及 預防結腸炎發病機理之因素的描述。 5.2.自發性關節炎模型： 163920.doc -33· 201245225
Kouskoff等人 ’ Ce// 87: 811-822 (1996)提供由全身性自 體免疫性引起之器官特異性疾病之模型。類風濕性關節炎 (Rheumatoid arthritis，RA)為慢性關節病，其特徵為白血 球侵襲及滑膜細胞活化’隨後為軟骨及骨破壞。Kouskoff 等人揭示藉由T細胞受體（T cell receptor，TCR)轉殖基因 系與NOD系雜交產生之自發性小鼠ra模型。所有子代均 顯現極易令人想起人類RA之關節病。鼠類病症之觸發為 由轉殖基因TCR機會性識別NOD源性主要組織相容性複合 體（MHC) II類分子；關節炎之進展涉及CD4+ T細胞、B細 胞及可能存在之骨趙細胞。 5.3.勝原蛋白誘發之關節炎（Co丨lagen Induced Arthritis， CIA)模型：
Brand等人，Mo/. Mec?· 102: 295-312 (2004)提 供膠原蛋白誘發之關節炎之小鼠模型。膠原蛋白誘發之關 節炎（CIA)為可在齧齒動物（大鼠及小鼠）及非人類靈長類動 物之易感染系中藉由用II型膠原蛋白（CII)(亦即關節軟骨之 主要成分蛋白質）免疫接種而引發的自體免疫疾病。在免 疫接種後’動物顯現與RA共有若干臨床及組織特徵之自 體免疫多發性關節炎。在齧齒動物中容易感染Cia與主要 組織相容性複合體（MHC) II類分子有關，且對cii之免疫 反應之特徵在於刺激膠原蛋白特異性T細胞及產生高效價 之對免疫原（異源CII)與自身抗原（小鼠CII)具特異性之抗 體。在組織學上，鼠類CIA之特徵在於與關節炎之臨床發 作一致之嚴重滑膜炎。由於CIA與RA之間具有病理相似 163920.doc •34- 201245225 性’故此實驗資料適用於評估CIA。 5·4.抗原誘發之τ細胞增殖.活體内模型： 使用τ細胞受體（TCR)-轉殖基因τ細胞之過繼性轉移為抗 原誘發之Τ細胞增殖提供活體内模型。Pape等人， hv. 156: 67-78 (1997)揭示均一地表現具有已知 肽/MHC特異性之可識別丁(：11的1^1轉殖基因丁細胞之過繼 性轉移。可使用該模型來監測抗原特異性τ細胞之活體内 行為。未處理T細胞最初在次級淋巴組織之τ細胞區内活化 以按Β7依賴性方式增殖。若此時期内存在佐劑或發炎性細 胞激素，則Τ細胞積聚數目增多，遷移至富β細胞之小囊中 且獲得產生IFN-γ之能力且有助於Β細胞產生IgG2a ^若發 炎得以有效括抗，則大部分最初活化之抗原特異性T細胞 會消失而不進入小囊中，且倖存者為IL-2及IFN-γ之不良產 生者。 實例 表3列出適用於本發明抗體多肽之代表性抗人類CD40可 變域胺基酸序列。表4揭示編碼表3中所列之可變域序列之 代表性核酸。如此項技術中所熟知，多個密碼子可編碼同 一胺基酸。因此，編碼蛋白質序列之核酸包括具有密碼簡 併性之核酸。表3中所不之抗體多狀特異性結合C D 4 0且使 用以下實例中所述之反覆初始/初步篩檢及親和力成熟方 法來製造。 163920.doc •35· 201245225 表3 抗人類CD40可變域胺基酸序列 BMS3h-56-201 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPQ6TRTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSS (SEQ ID NO： 9) BMS3H-56-258 EVQLLES6GGLVQP6GSLRLSCAAS6FTFRDYEMWWVRQAP6KGLERVSAINPQ6TRTYYADSVK6RFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSS (SEQ ID NO: 10) BMS3H-37 EVQLLESGGGLVQPG6SLRLSCAASGFTFEWYEMQWVRQAPGK6LEWV5AIS6D6YRTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKELGYFDYWGQGTLVTVSS (SEQ ID NO: 11) BMS3h-38 EVQLLESGGGLVQPG6SLRLSCAASGFTFEEEEMIWVRQAP6K6LEWVSAI56SGGSTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKEPFRFDYWGQGTLVTVSS (SEQ ID NO: 12) BMSBh-41 EVQLLES6GGLVQPGGSLRLSCAASGFTFTEYEMIWVRQAP6K6LEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVyYCAKEPLRFDY^QGTLVTVSS (SEQ ID NO： 13)
BMS3h-4B EVQLLESGGGLVQPGGSLRLSCTASGFTFNMYEMSWVRQAPGKGLEWVS6ISRR6FTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPITYAMRYARFDYWGQGTLVTVSS (SEQ ID NO： 14) BMS3h-56 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERV5AINPQGTRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFIFDYWGQ6TLVTVSS (SEQ ID NO: 15) BMS3H-106 EVQLLESGGGLVQP6GSLRLSCAASGFTFSTYHMQWVRQAPGKGLEWVSMIDADGLGTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKPGPQFGQFDYWGQGTLVTVSS (SEQ ID NO： 16) 36- 163920.doc 201245225 BMS3h-107 EVQLLES6G6LVQPGGSLRLSCAAS6FrFS6YDMQWVRQAP6KGLEWVSTISAS6VFTYYADSVK6RFTTSRDNSKNTL YLQMNSLRAEDTAVYYCAKYPNRFALNNFDYWGQGTLVTVSS (SEQ ID NO: 17) BMS3h-131 DIQMTQSPSSLSASVGDRVTITCRANSSILWALAWYQQKPGKAPKLLIESSSGLQSGVPSRFSGSGS6TDFTLTISSLQ PEDFATYYCVQNAGWPGTFGQGTKVEIKR (SEQ ID NO: 18)
BMS3h-19B DIQMTQSPSSLSASVGDRVTITCRASQriERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISStQ PEDFATYYCHQYASPPLTFGQGTKVEIKR (5EQ ID NO: 19) BMS3h-198 EVQLLESG6GLVQP6GSLRLSCAASGFTFA6YEMWWVRQAP6KGLERVSAIS6S6G5TYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDYWGQGTLVTVSS (SEQ ID NO： 20) BMS3h-202 EVQLLESGGGLVQPGGSLRLSCAASGFrFPTAEMVWVRQAPGKGLEWVSSISASGGSTYYAOSVKGRFTISRDNSKNTL YLC^INSLRAEDTAVYYCAKEPVSWATFDYWGQGTLVTVSS (SEQ ID NO: 21) BMS3h-217
DIQMTQSPSSLSASV6DRVTITCRASHFI6TLLSWYQQKP6KAPKLLITY6SLLQSGVPSRFSGSGSGT0FTLTISSLQ PEDFATYYC6QGVLWPATFGQGTKVEIKR (SEQ ID NO: 22) BMS3H-1 EVQLLES6G6LVQP6GSLRLSCAASGFTFPKNEMTWVRQAPGKGLEWVSAIESDGQATYYA0SVK6RFTISR0NSKNTL YLQMNSLRAEDTAVYYCAKNRIPDLVFDYWGQGTLVTVSS (SEQ ID NO： 23) BM53H-2 EVQLLESG6GLVQP6GSLRLSCAAS6FTFDAGAMTWVRQAPGKGLEWVSSIOKE6LSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6RIP6LVFDYWGQGTLVTVSS (SEQ ID NO： 24) BMS3h-3 EVQLLESGG6LVQPGGSLRLSCMS6FTFGDAAMTWVRQAPGKGLEWVSAIQPMGDGTYYADSVKGRFTVSRDNSKNTL YLQMNSLRAEDTAVYYCAK6RIPTLQFDYWGQ6TLVTVSS (SEQ ID NO： 25) BMS3h-4 EVQLLESGGGLVQPGGSLRLSCAASGFTFEDSPMTWVRQAPGKGLEWVSAITSNGYETYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGRIPTLHFDYWGQGTLVTVSS (SEQ ID NO： 26) BMS3h-5 EVQLLE5CGGLVQPGGSLRLSCAASGFTFDEHDMSWVRQAP6KGLEWVSRIGPDGFHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAWYCAKGRIPTLHFDYWGQGTLVTVSS (SEQ ID NO: 27) BMS3h-6 EVQLLESG6GLVQPG65LRLSCAAS6FTFGEYHMSWVRQAPGK6LEWVSRITPL6TLTYVADSVKGRFTISRDNSKNTL YLQMMSLRAEDTAVYYCAKGRIPSLTFDYWGQGTLVTVSS (SEQ ID NO: 28) 37· 163920.doc 201245225 BMS3h-7 EVQLLES6GGLVQPG6SLRLSCAAS6FTF6TNAMSWVRQAP6K6LEWVSRISPGGDYTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKGRVPDLLFDYWGQ6TLVTVSS (SEQ ID NO： 29) BMS3h-8 EVQLLESG6GLVQPGGSLRL5CAASGFTFPSEEMSWVRQAPGK6LEWVSRISADGANTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDAAVYYCAKGRVPDLLFDYWGQGTLVTVSS (SEQ ID NO: 30) BMS3h-9 EVQLLESG6GLVQP66SLRLSCAAS6FTFAEDDMTWVRQAPGKGLEWVSRIAVDGDRTYYADSVKGRFTISRDNSKNTL YLQMN5LRAEDTAVYYCAKGKVPSLHFDYW6QGTLVTVSS (SEQ ID NO： 31) BMS3h-10 EVQLLESG6GLVQPG6SLRLSCAASGFTFRTM0MSWVRQAPGKGLEWVSRITGD6MNTYYADSVKGRFTISRDNSKNTL YLQMNSLRA6DTAVYYCAK6VTPDLTFDYWGQ6TLVTVSS (SEQ ID NO： 32) BMS3h-ll EVQLLESGGGLVQPG6SLRLSCAASGFTFERDDMTWVRQAPGKGLEWVSRINAGGVHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6VTPDLTFOYWGQGTLVTVSS (SEQ ID NO: 33) BMS3h-12 EVQLLES6GGLVQPGGSLRLSCAA56FTFDDDSMTWVRQAPGK6LEWVSRISSD6A5TYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6VTPDLTFOYWGQ6TLVTVSS (SEQ ID NO: 34) BMS3h-13 EVQLLESGGGLVQPG6SLRLSCAASGFTFTEEDMTWVRQAPGKGLEWVSRIDSVGEGTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGVTPDLTFDYWGQGTLVTVSS (SEQ ID NO： 35) BMS3H-14 EVQLLESGGGLVQPG6SLRLSCAAS6FTFSDSAMSWVRQAPGKGLEWVSRIDNP6QHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGTVPTLEFDYWGQGTLVTVSS (SEQ ID NO： 36) BMS3h-15 EVQLLESCGGLVQPG6SLRLSCAASGFTFGQHSMTWVRQAPGK6LEWVSRID6G6YNTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGEVPRLHFDYWGQGTLVTVSS (SEQ ID NO： 37) BMS3h-16 EVQLLESG6GLVQPGGSLRLSCAASGFTFGQEPMTWVRQAP6KGLEWVSRIAYN660TYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6ITPNLTFDYW6QGTLVTVSS (SEQ ID NO: 38) BMS3h-17 EVQLLESGGGLVQPGGSLRLSCAASGFTFENYPMSWVRQAPGKGLEWVSRINATGSITYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGVIPHLMFDYWGQGTLVTVSS (SEQ ID NO: 39) BMS3h-18 EVQLLESGGGLVQPGG5LRLSCAASGFTFRDYDMSWVRQAPGK6LEWVSRIT6T6NSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAQ6WPYUFDYWGQ6TLVTVSS (SEQ ID NO： 40) 8MS3h-19 EVQLLESGGGLVQPG6SLRLSCAAS6FTFEADAMTWVRQAPGKGLEWVSRINVD6DRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6TVPTLEFDYWGQ6TLVTVSS (SEQ ID NO: 41) 38· 163920.doc 201245225 BMS3h-21 EVQLLES6G6LVQPGGSLRLSCAAS6FTFDRAmTWVRQAPGKGLEWVSRISGE6KCTYYADSVK6RFTISRDNSKNTL YL(yiNSLRAEDTAVYYCAKGMVPNLVFDYWGQ6TLVTVSS (SEQ ID NO： 42) BMS3h-22 EVQLLES66GLVQPG6SLRLSCAASGFTFHWEPMSWVRQAPGK6LEWVSRINSSGWDTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAmCAKGMVPNLVFDYWGQGTLVTVSS (SEQ ID NO： 43) BMS3h-24 EVQLLESGGGLVQPGGSLRLSCAASGFTFADEPMTWVRQAPGKGLEWVSRIPPEGAPTYYAOSVKGRFTISRDNSKNTL YLQMNSLRAEDTAmCAKGITPNLTFDYWGQGTLVTVSS (SEQ ID NO: 44> BMS3h-26 EVQLLESGGGLVQPG6SLRLSCAASGFTFHNHDMSWVRQAPGK6LEWVSRISR66LQTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGIVPDLHFDYWGQGTLVTVSS (SEQ ID NO： 45) BMS3h-27 EVQLLES6GGLVQPG6SLRLSCAAS6FTFNEYPMSWVRQAPGK6LEWVSRINGDGANTVYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGIIPAMQFDYWGQGTLVTVSS (SEQ ID NO： 46) BMS3h-28
EVQLLESGGGLVQPG6SLRLSCAAS6FTFGDVPMSWVRQAPGKGLEWVSRIDPYGSNTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGIMPSLTFDYW(^SGTLVTVSS (SEQ ID NO: 47) BMS3h-29 EVQLLESGGGLVQPG6SLRLSCAASGFTFADYDMSWVRQAPGKGLEWVSRISAL6ATTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6QLPALEFDYWGQ6TLVTVSS (SEQ ID NO: 48) BMS3h-30 EVQLLES6GGLVQPGGSLRLSCAASGFTFKRYYMTWVRQAPGKDLEWVSGIVPSGNRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGRIPDLHFDYWGQGTLVTVSS (SEQ ID NO： 49) BMS3h-31 EViJLLESGGGLVQPGGSLRLSCMSGFTFAOYDMTWVRQAPGKGLEWVSRISPTGGQTYYADSVKGRFTISRDNSKNTL· YLQMNSLRAEDTAVYYCAKGVIPYLSFSPFDYWGQGTLVTVSS (SEQ ID NO： 50) BMS3h-32 EVQLLESGGGLVQPGGSLRLSCAAS6FTFSKYWMGWARQAPGKGLEWVSSIDSR6AGTYYADSVKGRFTISRI»ISKNTL YLQMNSLRVEDTAVYYCAKGAPKFMT1YTFDYWGQGTLVTVSS (SEQ ID NO： 51) BMS3K-33 EVQLLESG6GLVQPGGSLRLSCAASGFTFLSYPMHWVRQAPGKGLEWVSSIDSRGSVTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGHSWTFD\WGQ6TLVTVSS (SEQ ID NO： 52) BMS3H-34 EVQLLESGGGLVQPGGSLRLSCAASGFTFANSNMTWVRQAPGK6LEWVSRINP0GGSTYYA0SVKGRFTISR0NSKNTL YLQMNSLRAEDTAVYYCAEGRIPTLHFDYWGQ6TLVTVSS (SEQ ID NO： 53) 39· 163920.doc 201245225 BMS3H-35 EVQLLES6GGLVQPGGSLRLSCAASGFTFGPRRMGWVRQAP6KGLEWVSSIDDIGRRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAEGAQGVLLFDYWGQGTLVTVSS (SEQ ID NO： 54) BMS3h-36 EVQLLESGGGLVQPGGSLRLSCAASGFTFEDYRMVWVRQAPGKGLEWVSSISTSGELTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAETAGQFFDYWGQGTLVTVSS (SEQ ID NO: 55) BMS3h-39 EVQLLESGGGLVQPGGSLRLSCAASGFTFPEYEMVWVRQAPGKGLEWVSAISREGRATYYADSVKGRFTISRDNSKNTL YLQMNNLRAEDTAVYYCAKEPVRFDYW6QGTLVTVSS (SEQ ID NO: 56) BMS3h-40 EVQLLES6GGLVQP6GSLRLSCAASGFTFSTYEMLWVRQAPGKGLEWVSSI5SSGNYTm〇SVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLMFDYWGQGTLVTVSS (SEQ ID NO： 57) BMS3H-42 EVQLLESGGGLVQPGGSLRLSCAASGFTFDTEEMSWVRQAPGKGLEWVSAISPNGAFTFYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPILF0YWGQ6TLVTVSS (SEQ ID NO: 58) BMS3h-44 EVQLLESGGGLVQPGGSLRLSCAASGFTFGHYDMVWVRQAPGRGLEWVSTINGAGLNTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAQSASRIFDYWGQGTLVTVSS (SEQ ID NO: 59) BMS3H-45 EVQLLESGGGLVQPG6SLRLSCAASGFTFRSYEMAWVRQAPGK6LEWVSSI5TLGTKTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAQSSTHIFDYW6QGTLVTVSS (SEQ ID NO: 60) BMS3h-46 EVQLLESGGGLVQPG6SLRLSCAAS6FTFIRYEMAWVRQAPGKGLEWVSSISSSGWTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKSDAHIFDYWGQGTLVTVSS (SEQ ID NO: 61) BMS3K-47 EVQLLESG6GLVQPGGSLRLSCAASGFTFYAYEMAWVRQAPGKGLEWVS5ISDD6TRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDLGQGFDYWGQ6TLVTVSS (SEQ ID NO: 62) BMS3h-48 EVQLLES6GGLVQP66SLRLSCAASGFTFADHGMTWVRQAP6K6LEWVSGI6PSGEATYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDRIPNLVFDYWGQGTLVTVSS (SEQ ID NO: 63) BMSBh-49 EVQLLESGGGLVQPGGSLRLSCAASGFTFESQDMSWVRQAPGK6LEWVSGISPNGWDTYYADSVKGRFTISRDNSKNTL YLQMN5LRAEDTAVYYCAKDRSOFDYWGQ6TLVTVSS (SEQ ID NO: 64) BMS3h-50 EVQLLESGGGLVQP6GSLRLSCAASGFTFGDYDMWWVRQAPGKGLEWVSRIRHPGGVTYYADSVKGRFTISRDNSKNTL YLQMN5LRAEDTAVYYCAKAVPKGFDYWGQGTLVTVSS (SEQ ID NO: 65) BMSBh-51 EVQLLESGGGLVQPGGSLRLSCAASGFTFRVYWMTWVRQAP6K6LEWVSSIDPQGGMTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKARIPNLEFDYWGQ6TLVTVSS (SEQ ID NO： 66) 40· 163920.doc 201245225 BMS3h-52 EVQLLES666LVQP6ESLRLSCAASGrFSAYDMTWVRQAPGKGLEWVSRINPTGSYTYYADSVK6RFTISR0NSKNTL YLQMNSLRAEDTAVYYCAKAKIPNLVF0YW6Q6TLVTVSS (SEQ 10 NO： 67) BMSBh-53 EVQLLESGGGLVQPGGSLRLSCAASGF"FADSEMMWVRQAPGKGLEIWSGIAHN66HTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKAGHPQQTE>VFDYWGQGTLVTVSS (SEQ ID NO： 68) BMS3h-54 EMQLLESGGGLVQPGGSLRLSCAASGFrFATYDMYWVRQAPGKGLEWVSKISPNGWSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAWYCAKYQTHFDYW(5Q6TLVTVSS (SEQ ID NO： 69) BMS3h-55 EVQLLESGG6LVQPGGSLRLSCAASGFTFSVYDMRWVRQAP6K6LeWVSTISSSGTYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKYPKNFDYW(5QGTLVTVSS (SEQ ID NO： 7Θ) BMS3H-57 EVQLLES6GGLVQPG6SLRLSCAASGFTFSHEDMTWVRQAPGKGLEWVSSISPNGWDTYYADSVKGRFTISRDNSKNTL YLQfWSLRAEDTAVYYCAKRTRSKFDWGQGTLVTVSS (SEQ ID NO: 71) BMS3h-58
EVQLLESGGGLVQPGGSLRLSCAASGFTFEmMGWARQAPGKGLEWVSTIOYWGQHTYYADSVKGRFTISRONSKNTL YLQMNSLRAEDTAVYYCAKRSHLIPLQFDYWGQGTLVTVSS (SEQ ID NO： 72) BMS3h-59 EVQLLESGGGLVQP6G5LRLSCAASGFTF5DYAM6WVRQAPGKGLEWVSTISYV6YYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKKALRGEAFTERFDYW6QGTLVTVSS (SEQ ID NO： 73) BMS3h-60 EVQLLESGGGLVQPGGSLRLSCAASGFTFGPYMMHWVRQAP6K6LEWVSTIEVN6NRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKWVGSKTSSDKSFDYWGQGTLVTVSS (SEQ ID NO： 74) BMS3H-61 EVQLLESGG6LVQPGGSLRLSCAASGFTFGTTEMAWVRQAPGKGLEWVSSIGSAGAWTYYADSVK6RFTISR0NSKNTL YLQMNSLRAEDTAVYYCAKIGGHPQGQFDYWGQGTLVTVSS (SEQ ID NO： 75) BMS3h-62 EVQLLESGGGLVQPGGSLRLSCAASGFTFPREmAWVRQAPGKGLEWVSSIQPMGQTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKYSRNKGFFDYWGQGTLVTVSS (SEQ ID NO: 76)
BMS3h-6B EVQLLESGGGLVQPG6SLRLSCAASGFTFTSEYMGWVRQAPGKGLEWVSSIQRY6STTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKHESNWETFDYWGQGTLVTVSS (SEQ ID NO: 77) BMS3H-70 EVQLLESGGGLVQPGGSLRLSCAASGFTFSVYSMQWVRQAPGKGLEWVSAITPNGTRTYYADSVKGRFTISRDNSICNTL YLQIWSLRAEDTAVYYCAKTLGRGSYPGVDFDYWGQGTLVTVSS (SEQ ID NO： 78) •41 - 163920.doc 201245225 BMS3h-71 EVQLLESG6GLVQPG6SLRLSCAASGFTFPSYAMTWVRQAP6K6LEWVSRITADGTVTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGSIPMLTFDYWGQ6TLVTVSS (SEQ ID NO: 79) 8MS3h-72 EVQLLESGGGLVQP6GSLRLSCAASGFTFSTYDMIWVRQAPGKGLEWVSAISPNGTGIYYA0SVKGRFTISR0NSKNTL YLQMNSLRAEDTAWYCAKNQSVHHAVFDYWGQGTLVTVSS (SEQ ID NO: 8Θ) BMS3h-73 EVQLLES666LVQPGGSLRLSCAASGFTFENYEMTWVRQAPGKGLEWVSRIAPHGRLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGQIPMLDFDYWGQGTLVTVSS <SEQ ID NO： 81) BMS3h-74 Εν(}ΙΛΕ$6661Λ/(ΪΡ66$1·Κ1^αΑΑΜΡΤΡ5ΗΥΜΜΜΝνΚ〇ΑΡ6Κ611ΕΝν5 了 ISHFGDITYYADSVKGRFTISRDNSKNTL YL(^SLRAEDTAmCAKNDMVMKN66FDYWGQ6TLVTVSS (SEQ ID NO： 82) BMS3h-75 EVQLLESGGGLVQPGGSLRLSCAASGFTFERYDMSWVRQAPGKGLEWVSRIDSRQrfSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGLVPHLRFDYWGQGTLVTVSS (SEQ ID NO： 83) BM53h-76 EVQLLES6GGLVQPG6SLRLSCAASGFTFAN/Mim/VRQAP6KGLEWV5RIDAM6DATYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGKVPSIDYWGQ6TLVTVSS (SEQ ID NO： 84) BMS3h-77 EVQLLESGGGLVQPGGSLRLSCAAS6FTFANAQMTWVRQAPGK6LEWVSRIDAM6DATYYADSVKGRFTISRDNSKNTL YLQMNSLRAEOTAVYYCAKGVIPAFDYWGQGTLVTVSS (SEQ ID NO: 85) BMS3h-78 EVQLLESGG6LVQPGGSLRLSCAASGFTFQNDRMHWVRQAPGKGLEWVSSISATGGDTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKQTGTNRFDYWGQGTLVTV5S (SEQ ID NO： 86) BMS3h-79 EVQLLES6GGLVQPGGSLRLSCAASGFTFNQPYMSWVRQAPGK6LEWVSSIDASGGTTYYADSV1C6RFTISRDNSKNTL YLQMNSLRAEDAAVYYCAKDRIPNLVFDYWGQ6TLVTVSS (SEQ ID NO： 87) BMS3h-80 EVQLLESG66LVQPGGSLRLSCAASGFTFDNENMTWVRQAP6K6LEWVSRIDGGGYNTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGQVPELLFDYWGQGTLVTVSS (SEQ ID NO: 88) BMS3h-81 EVQLLES6GGLVQPGGSLRLSCAASGFTFVSSNMTWVRQAPGKGLEWVSAIS6SGGSTYYADSVKGRFTISR0NSKNTL YLQMNSLRAEDTAVYYCAKGRIPTLVFDYW6QGTLVTVSS (SEQ ID NO： 89) BMS3h-82 EVQLLES6GGLVQPGGSLRLSCAASGFTFVSSNMTWVRQAP6K6LEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDRIPNLVFDYWGQGTLVTVSS (SEQ ID NO: 90) BMS3h-83 EVQLLES6GGLVQPGGSLRLSCAASGFTFSDDSMSWVRQAPGKGLEWVSRINDAGSSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6TIPLLEFDYW6QGTLVTVSS (SEQ ID NO： 91) 42- 163920.doc 201245225 BMS3h-84 EMQLLESGGGLVQPGGSLRLSCMSGFTFVSDTMSWVRQAP6KGLEWVSRID6TGGDTYYADSVKGRFTISRDNSKNTL YLQMNSLRAGDTAVYYCAKGLIPDLQFDYWGQGTLVTVSS (SEQ ID NO： 92) BMSBh-85 EVQLLES6GGLVQPGGSLRLSCAASGFTFDEEEMTWVRQAPGK6LEWVSRII6GGHETYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGTIPLLEFDYWGQGTLVTVSS (SEQ ID NO: 93) BMS3h-86 EVQLLESG6GLVQPG6SLRLSCAASGFTFDNENMTWVRQAPGKDLEWVSRITERGDVTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGTVPTLEFDYWGQGTLVTVSS (SEQ ID NO： 94) BMS3h-87 EVQLLESGGGLVQPG6SLRLSCAASGFTFDEEEMTWVRQAPGKGLEWVSRIIGGGHETYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGTVPTLEFDYWGQGTLVTVSS (SEQ ID NO： 95) BMS3h-88 EVQLLESGGGLVQPGGSLRLSCAAS6FTFHETEMTWVRQAPGK6LEWVSAINRLGQDTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGRIPGLVFDYWGQGTLVTVSS (SEQ ID MO： 96) BMS3h-89
EVQLLESGGGLVQPGGSLRLSCAASGFTFSDDSMSWVRQAPGKGLEWVSRINDAGSSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6TVPTLEFDYW6QGTLVTVSS (SEQ ID NO: 97) BMS3h-90 EVQLLES6G6LVQP66SLRLSCAAS6FTFDNENMTWVRQAPGKDLEWVSRITERGDVTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGRIPTLVFDYWGQ6TLVTVSS (SEQ ID NO： 98) BMS3K-91 EVQLLESGGGLVQPGGSLRLSCAASGfTFSDDSMSWVRQAPGKGLEWVSRINDAGSSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGITPNLTFDYW6Q6TLVTVSS (SEQ ID NO： 99) BM53h-92 EVQLLESGGGLVQPG6SLRLSCAASGFTFADEPMTWVRQAPGKGLEWVSRIPPEGAPTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGLIPDLQFDYWGQGTLVTVSS (SEQ ID NO： 100) BMS3h-93 EVQLLES66GLVQPGGSLRLSCAASGFTFQDSDMTWVRQAP6KGLEWVSAIAAPGGSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDRIPNLRrDYWGQGTLVTVSS (SEQ ID NO： 101) 8MS3h-94 EVQLLESGGGLVQPGGSLRLSCAASGFTFVSDTMSWVRQAPGKGLEWVSRIDGT6GDTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKGQVPELLfDYWGQGTLVTVSS (SEQ ID NO： 102) BMS3h-95 EVQLLESGGGLVQPGGSLRLSCAASGiTFQDSDMTWVRQAPGKGLEWVSAIAAPGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAmCAKDRIPNLVi:DYWC5Q6TLVTVSS (SEQ ID NO： 103) 43· 163920.doc 201245225 BMS3h-96 EVQLLES666LVQP66SLRLSCAAA6FTFDLAEM7WVRQAP6K6LEWVSRIDEDGASTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDAAVYYCAEGVIPSLTFDYWGQGTLVTVSS (SEQ ID NO: 104) BMS3h-97 EVQLLESGGGLVQP66SLRLSCAAS6FTFTDKHMSWVRQAP6K6LEWVSRISPDGTYTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDAAVYYCAEGVIPSLTFDYWGQGTLVTVSS (SEQ ID NO: 105) BMS3h-98 EVQLLESG6GLVQPG6SLRLSCAASGFTFAEDDMTVIVRQAPGKGLEWVSRIAVDGDRTYYADSVKGRFTISRDNSKNTL YLQMNSLRTEDTAVYYCAKGKTPHLVFDYWGQGTLVTVSS (SEQ ID NO: 106) BMS3h-99 EVQLLESGGGLVQPG6SLRLSCAAAGFTFDLAEMTWVRQAPGK6LEWVSRIDEDGASTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGQVPALVFDYWGQGTLVTVSS (SEQ ID NO: 107) BMS3h-100 EVQLLESG6GLVQPGGSLRLSCAASGFTFEDSMMSWVRQAPGKGLEWVSRIDP6GAQTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6VTPDLTFDYWGQGTLVTVSS (SEQ ID NO: 108) BM53h-101 EVQLLESGGGLVQPGGSLRLSCAASGFTFEHADMSWVRQASGK6LEWVSRIDNSGQSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAK6VTPDLTF0YWGQGTLVTVSS (SEQ ID NO： 109) BMS3h-102 EVQLLESG6GLVQPGGSLRLSCAAS6FTFSEAEMNWVRQAP6K6LEWVSRITTDGC6TYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGRIPTLHFDYWGQGTLVTVSS (SEQ ID NO： 110) 6MS3h-103 EVQLLES6GGLVQP6GSLRLSCAAS6FTFDDSDMTWVRQAPGKSLEWVSYIR6DDDETYYA0SVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKNRIPDLVFDYWGQGTLVTVSS (SEQ ID NO： 111) BMS3h-108 YLQMNSLRAEDTAVYYCAKHASTE6PTAFDYWGQGTLVTVSS (SEQ ID NO： 112) BMS3h-109 EVQLLESGGGLVQPGGSLRLSCAASGFTFGPYDM6WVRQAPGKGLEWVSWISAHGSFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKWPYKFDYWGQGTLVTVSS (SEQ ID NO： 113) BMS3h-110 EVQLLESGGGLVQPG6SLRLSCAASGFTFGSGSMSWVRQAPGKGLEWVSRIGSN6ADTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGMVPNLVFOYWGQGTLVTVSS (SEQ ID NO： 114) BMSBh-111 EVQLLES6GGLVQP66SLRLSCAASGFTFNRFDMTWVRQAPGK6LEWVSAISGSG6STYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDRIPNLVFDYWG<^TLVTVSS (SEQ 10 NO: 115) BMSBh-112 EVQLLESGGGLVQPGGSLRLSCAASGFTFGESDMKWVRQAP6KGLEWVSSISPNGWDTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKSPSSRLKFDYWGQ6TLVTVSS (SEQ ID NO： 116) 44· 163920.doc 201245225 BMS3H-139 EVQLLESGGGLVQPGGSLRLSCMSGFTFDSSEMSWVRQAPGKGLEWVSSIENQGGATYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDRIPNLVF0YWGQ6TLVTVSS (SEQ ID NO： 117) BMSBh-140 EVQLLES6GGLVQPGGSLRLSCAASGFTLDAYPMYWVRQAF6KGIEWVSWIASGG6ATYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKRTKNFDYWCiQOTLVTVSS (SEQ ID NO： 118) BMS3h-141 EVQLLESGGGLVQPGGSLRLSCAASGFTFMSYSMAWVRQAPGK6LEWVSGITSNGNRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKSTGANSRNf:DYWGQGTLVTVS5 (SEQ ID NO: 119) BMS3h-142 EVQLLESGGGLVQP6GSLRLSCAASGFTFEGYLMSWVRQAPGKGLEWVSSIAANGMQTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKKPRGIWDG[)FDYWGQGTLVTVSS (SEQ ID NO： 120) BMS3H-143 EVQLLESGGGLVQPGGSLRLSCAASGFTFHESTMTWVRQAPGKGLEWVSTIRHPGEFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAGDTAVYYCAKGLIPDLQF[)YWGQGTLVTVS$ (SEQ ID NO： 121) BMS3h-144
EVQLLESGGGLVQPGGSLRLSCAASGFITAMYSMSWVRQAPGKGLEWVSSIAPPGGRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKQSLTGYSRf；FDYWGQ6TLVTVSS (SEQ ID NO: 122) BMS3h-145 EVQLLESGGGLVQPGGSLRLSCAASGF'TSQNPMSWVRHAPGKGLEWVSTIPANGRPTSYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKYSQQP6RRI:DYWGQGTLVTVSS (SEQ ID NO： 123) BMS3h-146 EVQLLESGGGLVQPGGSLRLSCAASGF'TANYHMTWVRQAPGKGLEIaIVSSIPDSGKQTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGRIPSLLFDYW6QGTLVTVSS (SEQ ID NO： 124) BMS3h-147 EVQLLESGGGLVQPGGSLRLSCAASGFTFAQYHMRWVRQAPGKGLEWVSTINDIGSN7VYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKV6GRGSFSI:DYWGQGTLVTVSS (SEQ ID NO： 125) BMS3H-148 EVQLLES6GGLVQPGGSLRLSCAASGFTFSSYDMKWVRQAPGKGLEWVSTI5AS6VFTYYADSVKGRFTISRDNSKNTL YUJMNSLRAEDTAVYYCAKREHAGQPPFDYWGQGTLVTVSS <SEQ ID NO: 126> BMS3h-149 EVQLLES6GGLVQP66SLRLSCAAS6FTFNGYAMSWVRQAP6K6LEWVSTINANGICYTYYADSVKGRFTISR0NSKNTL YL(^1NSLRAEDTAVYYCAKKLTLASNYI=DYWGQGTLVTVSS (SEQ ID NO: 127) BTC3h-150 EVQLLESGG6LVQP6GSLRLSCAASGFTFMDYDMKWVRQAP6K6LEWVSSITAL6KKTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDSVKYPLNlFDYWGQGTLVTVSS (SEQ ID NO： 128) •45· 163920.doc 201245225 BMS3h-151 EVQLLES6GGLVQP66SLRLSCAASGFTFPHYTMAWVRQAPGK6LEWVSSIQSP6WRTYYADSVKGRFTISRDWSKNTL YLQMNSLRAEDTAVYYCAKYGDGLPLTFDYW6QGTLVTVSS (SEQ ID NO： 129) BM53h-167 EVQLLES6GGLVQP6GSLRLSCAASGFTFSGTPMSWVRQAPGKGLEWVSRIGDE6QETYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGVTPDLTFDYWGQGTLVTVSS (SEQ ID NO： 130) BMS3h-168 EVQLLESGG6LVQPGGSLRLSCAAS6FTFSSSSMSWVRQAP6K6LEWVSAI6SDGPSTYYADSVKCRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGRIPTLHFDYWGQGTLVTVSS (SEQ ID NO: 131) BMS3h-169 EVQLLESGGGLVQPGGSLRLSCAASGFTFNPGEMTWVRQAPGKGLEWVSSIDGSGSSTyYADSVKGRFTISRONSKNTL YLQMNSLRADDTAVYYCAKGRIPTLHFDYWGQGTLVTVSS (SEQ ID NO: 132) BMS3h-170 EVQLLESGGGLVQPGGSLRLSCAASGFTFPESMMGWVRQAPGK6LEWVSSI6YPGATTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGGSRDDNFDYW6QGTLVTVSS (SEQ ID NO： 133) BMS3卜171 EVQLLESGGGLVQPGGSLRLSCAASGFTFGQHSMHWVWJAPGKGLEWVSSISVPGPKTYYADSVKGRFTISRDNSICNTL YLQMNSLRAEDTAVYYCAKSLRDLRP6DSKSFDYWGQGTLVTVSS (SEQ ID NO: 134) BMS3h-197 EVQLLES6GGLVQPG6SLRLSCAASGFTFGSAAMDWVRQAPGKGLEWVSSINDMGSNTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKQGGRFDYWGQGTLVTVSS (SEQ ID NO： 135) BMS3h-199 EVQLLESGG6LVQPGGSLRL5CAAS6FTF6YDRMAWVRQAPGKGLEWVSSID6PGGATYYADSVKGRFTISRDNSKNTL YLQMNSLRAE0TAVYYCAE6RRVPDFDYW6QGTLVTVSS (SEQ ID NO： 136) BMS3h-200 EVQLLES6GGLVQPGGSLRLSCAASGFTFGEYEMTWVRQAPGK6LEWVSRIDPFGSETYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAEC5WPDLNFDYWGQGTLVTV5S (SEQ ID NO： 137) BMS3h-201 EVQLLES6GGLVQPG6SLRLSCAASGFTFDKYVM6WVRQAPGKGLEWVSTIGSYG6ATYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKRLTLSATKFDYWGQGTLVTVSS (SEQ ID NO： 138) BMS3h-203 EVQLLESGGGLVQPGGSLRLSCAASGFTFEDYVMGWVRQAPGKGLEWVSTIAHRGDITYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKRRRLSDYRFDVWGQ6TLVTVSS (SEQ ID NO: 139) BMS3h-204 EVQLLE5GGGLVQPGGSLRLSCAASGFTFGQFDMYWVRQAP6KGLEWVSAISPAGT6TYYADSVK6RFTI5RDNSKNTL YLQMNSLRAEDTAWYCAKA60RSSLFDYRGQ6TLVTVSS (SEQ ID NO： 14Θ) BMS3h-205 EVQLLES6G6LVQPGGSLRLSCAASGFTFKDTGMTWVRQAPGKGLEWVSSISSYGRDTYYADSVKGRFTISRDNSKNTL YLQMN5LRAEDAAVYYCAKLNAALGFDYWGQGTLVTVSS (SEQ ID NO： 141) 46-
163920.doc 201245225 BMS3h-206 EVQLLESGGGLVQP6GSLRLSCAASGFTF6PYPMSWVRQAPGK6LEWVSGINAPGTRTYYADSVK6RFTISRDN5KNTL YLQMNSLRAEDTAVYYCAQ(^SSGVFDYWGQ6TLVTV5S (SEQ ID NO: 142) BMS3h-207 EVQLLESGGGLVQP6GSLRLSCAASGFTFSNQDMTWVRQAPGKGLEWV5SIDSSGQLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAE0TAVYYCAKVK5LARF0YWGQ6TLVTVSS (SEQ ID NO: 143) BMS3h-208 EVQLLESGGGLVQPGGSLRLSCAASGFTFPESDMKWVRQAPGKGLEWVSSISPNGWDTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKPAQVLFDYWGQGTLVTVSS (SEQ ID NO： 144) BM53H-209 EVQLLESGGGLVQPGG5LRLSCAASGFTFEQYVM6WVRQAPGKGLEWVSTIGTS6KYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAQRRSLTRVHFDYWGQGTLVTVSS (SEQ ID NO： 145) BMS3h-210 EVQUESGGGLVQPGGSLRLSCAASGFTFGVEHMSWVRQAPGKGLEWVSAITGDGDRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKTVSWMGRFDYWGQGTLVTVSS (SEQ ID NO： 146) BMS3h-211
EVQLLES6GGLVQPGGSLRLSCAASGFTFAWYNMGWVRQAPGK6LEWVSRIAPS6IITYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGLRGKFDYWGQGTLVTVSS (SEQ ID NO： 147) BMSBh-212 EV<2LLESGGGLV<JPGGSLRLSCAASGFTFSNYEMRWVR<3APGKGUWVSSISSAGTDTYYADS VICGHFTISUDNSICNTL· YLQMNSLRAEDTAVYYCAKQSLNFOYUGQGTLVTVSS (SEQ ID NO： 148)
BMS3h-21B EVQLLES6GGLVQPGGSLRLSCVASGFTFDEEPMTWVRQAP6KGLEWVSIIDPGGGATYYADSVKGRFTISRDMSKNTL YLC^INSLRAEDTAVYYCAKSNSMFOYKGQGTLVTVSS (SEQ ID NO： 149) BMS3h-214 EVQLLESGGGLVQPGGSLRLSCAASGFTFSAYPMHWVRQAPGKGLEWVSSIASSGITTYYA0SVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKFTRLHFP^QFDYWGQGTLVTVSS (SEQ ID NO： 150) BMS3h-215 EVQLLESGGGLVQPGGSLRLSCAAS6FTFADYAMGWVRQAPGK6LEWVSRISPE6SRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLRPYASKFDYWGQGTLVTVSS (SEQ ID NO: 151) BMS3h-230 EVQLLESGGGLVQPGGSLRLSCAASGFTFRPYDMGWVRQAPGKGLEVA/STISHQGNRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKVSHHFDYVIGQGTLVTVSS (SEQ ID NO： 152) BMS3H-231 EVQLLESGGGLVQPGGSLRLSCAASGFTFSAVNMWWARQAPGKGLIrWVSWINSTGSRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKNWHRGRFC>YWGQGTLVTVSS (SEQ ID NO: 153) 47· 163920.doc 201245225 BMS3h-232 EVQLLES6GGLVQPGGSLRLSCAASGFTFDRYRM6WVRQAPGKGLEWVSTINRLGQSTYYADSVKGRFTISR0NSKNTL YLQMNSLRAEDTAVYYCAKVKKHKFDYWGQGTLVTVSS (SEQ ID NO： 154) BMS3h-233 EVQLLESGGGLVQP66SLRLSCAASGFTFAHYNMRWVRQAPGKGLEWVSTITKT6FRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKAGQFDFDYWGQ6TLVTVSS (SEQ ID NO: 155) BMS3h-234 EVQLLESG6GLVQPGGSLRLSCAAS6FTFYPYSMHWVRQAPGKGLEWVSTIDGSGMFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAEDSLKASFDYWGQGTLVTVSS (SEQ ID NO： 156) BMS3h-235 EVQLLESGGGLVQPGGSLRLSCAASGFTFPLYGMWWVRQAPGKGLEWVSYIGPYGHTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKKRKKKFDYWGQGTLVTVSS (SEQ ID NO： 157) BMS3h-236 EVQLLESGGGLVQP6GSLRLSCAASGFTFPRYRMSWVRQAPGKGLEWVSSITPYGAHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKY6KWYFDYWGQGTLVTVSS (SEQ ID NO： 158) BMS3h-237 EVQLLES6GGLVQPGGSLRLSCAASGFTFNEYAMRWVRQAP6KGLEWVSTIDRLGLHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKSGPFTFDYWGQGTLVTVSS (SEQ ID NO: 159) BM53h-238 EVQLLESGGGLVQPGGSLRLSCAASGFTFERYNMRWVRQAPGK6LEWVSTIDRLGLATYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKAGSWSFDYWGQGTLVTVS5 (SEQ ID NO: 160). BMS3h-239 EVQLLESGGGLVQPGGSLRLSCAASGFTFGIYDMKWVRQAPGKGLEWVSTISSS6THTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKYPQPYPFDYWGQGTLVTVSS (SEQ ID NO： 161) BMS3h-240 EVQLLESGGGLVQPGGSLRLSCAASGFTFWVYDMRWVRQAPGKGLEWVSTISATGVHTYYADSVKGRFTISRDNSKNTL YLQnNSLRAEDTAVYYCAKYPPAGRFDYWGQGTLVTVSS (SEQ ID NO； 162) 8M53h-241 EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYDMIWVRQAPGKGLEWVSAISPN6TGTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKPPQVNTEFDYRGQGTLVTVSS (SEQ ID NO： 163) BMS3h-243 EVQLLESGGGLVQPGGSLRLSCAAS6FTFEKEDMGWVRQAPGKGLEWVSHISPNGYATYYAE)SVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKSWSSFDYWGQGTLVTVSS (SEQ ID NO: 164) BMSBh-244 EVQLLESGGGLVQPGGSLRLSCAASGFTFSATPMEWARQAPGKGLEWVSTISES6YSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKWNSTTGFDYWGQGTLVTVSS (SEQ ID NO： 165) BMS3h-245 EVQLLESGG6LVQP6GSLRLSCAASGFTFNTVDMEWVRQAP6KGLEWVSSISPN6WDTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAEAPHRAFDYWGQGTLVTVSS (SEQ ID NO： 166) 48-
163920.doc 201245225 BMSBh-246 EVQLLESGGGLVQPGGSLRLSCAASGFTFEDKEMSWVRQAPGK6LEWVSRIDALGDSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAEGMVPRLKFDYWGQ6TLVTVSS (SEQ ID NO: 167) BMS3h-247 EVQLLESGGGLVQPGGSLRLSCAASGF 丁 FSOHSMMWVW2APGICGLEWVSDIEPH6VHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCANPTFDYW6Q<5TLVTVSS (SEQ ID NO: 168) BMS3H-248 EVQLLES6GGLVQPGGSLRLSCAASGFTFSPHTMHWVRQAPGK6LEWVSGIGPDGTTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKRSYSWDRQJTFDYWGQGTLVTVSS (SEQ ID NO： 169) BMS3h-249 EVQLLESGGGLVQPGGSLRLSCAAS6FTFYASDMKWVRQAPGKGLEWVSSISPMGWDTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKADYTYHSFDYWGQGTLVTVSS (SEQ ID NO： 170)
BMS3H-25' EVQLLESGi YLQMNSLR 3H-250 i66LVQPG6$LRLSCAASGFTFAHYNMRWVRQAP6KGLEWVSTITKTGFRTYYADSVKGRFTISRDNSKNTL ISLRAEDTAVYYCAKAGQFDFDYI^QGTLVTVSS (SEQ ID NO; 171) BMS3h-251
EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYHMGWARQAP6KGLEWVSVIGPRGISTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYVCAKSPSRHRFDW6QGTLVTVSS (SEQ 10 NO： 172) BMS3H-252 EVQLLES6G6LVQPGGSLRLSCAAS6FTFNEYAMRWVRQAPGKGLEWVSTIDRL6LHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKSGPFTFDYl^GQGTLVTVSS (SEQ ID NO: 173)
BMS3H-25B EVQLLESGGGLVQPGGSLRLSCAASGFTFGNYSMKWARQAPGKGLEWVSTITPDGWYmADSVKGRFTISRDNSKNTL yLQMNSLRAEDTAVYYCAKVGDAVWGWrGGFDYWGQGTLVTVSS (SEQ ID MO: 174) BM53h-254 EVQLLESGGGLVQPGGSLRLSCAASGFTFG0Y6MKWVRQAP<3KGLEWVSAITSMGDFTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAWYCAKSLYKFDYW-3Q6TLVTVSS (SEQ ID NO: 175) BMSBh-255 EVQLLES6G6LVQPGGSLRLSCAGSGFTFPTYKMGWVRQAPGK6LEWVSFIDYW6WRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKSPYSWTHDSPHFDYWGQGTLVTVSS (SEQ ID NO: 176) BMS3h-256 EVQLLES6GGLVQPGGSLRLSCAASGFTFRPVTMCWARQAP6K6LEWVSCISDAGSFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKRMSSFDYWGQ6TLVTV55 (SEQ ID NO： 177) BMS3H-257 EVQLLES6G6LVQP6GSLRLSCAASGFTFQNYQMAWVRQAPGKGLEWVSTIS6TGKNTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKTPQNYFSVRRFDYWGQGTLVTVSS (SEQ ID NO： 178) 49- 163920.doc 201245225 BMS3h-258 EVQLLES6GGLVQP6GSLRLSCAAS6FTF6AYTMGWVRQAP6K6LEWVSKISTS6GQTYYADSVK6RFTISRDN5KNTL YLQMN5LRAEDTAVYYCAKPLNWWAFDYW6QGTLVTVSS (SEQ ID NO： 179) BMS3h-272 EVQLLES6GGLVQPG6SLRLSCAAS6FTFNAYPMTWVRQAP6K6LEWVSftID6Y6RHTYYADSVK6RFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKGIIPNFDYWGQGTLVTVSS (SEQ ID NO： 18Θ) BMS3h-273 EVQLLESGGGLVQPG6SLRLSCAASGFTFGAVDMTWVRQAPGKGLEWVSAISPS6SATYYADSVKGRFTISR0NSKNTL YLQWSLRAEDTAVyYCAK6HVPDLGFDYWGQGTLVTVSS (SEQ ID NO； 181) BMS3H-274 EVQLLESGGGLVQPGGSLRLSCAAS6FTFDSYAMGWARQAPGKGLEWVSAI6AK6LSTVYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKAARGKFDYWGQGTLVTVSS (SEQ ID NO： 182) BMS3K-275 EVQLLESGGGLVQPGGSLRL5CAASGFTFTRYQM6WVRQAP6K6LEWVSVINVWGSSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKMSGKFAYWGQGTLVTVSS (SEQ ID NO： 183) BMS3h_276 EVQLLESGGGLVQPGGSLRLSCAASGFTFGNYSMMWVRQAPGKGLEWVSTIIPAGTSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKPSIRLFDYWGQGTLVTVSS (SEQ ID NO： 184) BMS3h-279 EVQLLESGGGLVQP6G5LRLSCAASGFTF6AYDMGWVRQAPGKGLEWVSWISPN6YDTYYADSVKGRFTISRONSKNTL YLQMNSLRAEDTAVYYCAKGGVKFDYW6Q6TLVTVSS (SEQ ID NO： 185) BMS3h-282 EVQLLESGG6LVQPGG5LRLSCAASGFTFVWYEMAWVRQAPGKGLEWVSTIQAD6EQmADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKA5YALVYPPEEFDYWGQGTLVTV5S (SEQ ID NO： 186) BMS3h-287 EVQLLESGGGLVQPG6SLRLSCAAS6FTFTNYRMSWVRQAPGKGLEWVSAIDDL6VSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKWRLKNSQPTOFOYWGQGTLVTVSS (SEQ ID NO： 187) BMS3h-292 EVQLLES6GGLVQPGGSLRL5CAASGFTFDQAHMWWVRQAPGKGLEWVSFINPS6YVTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKPSLSPSSFDYWGQGTLVTVSS (SEQ ID NO: 188) BMS3H-293 EVQLLE5GGGLVQPGCSLRL5CAASGFTFETGQM6WARQAPGKGLEWVSNID6S6TYTYYADSVKGRFTISRDNSKNTL VLQMNSLRAEDTAVYYCAK5TQNYRFDYWGQ6TLVTVSS (SEQ ID NO： 189) BMS3h-296 EVQLL ESGGGLVQPGGS LR LSCAASGFTFGAYPMYWVRQAPGKGLEWVSSIHKDGRITYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKQGTPVDGFDYWG(26TLVTVSS (SEQ ID NO: 190) BMS3h-297 EVQLLESGGGLVQPGGSLRLSCAASGFTFPDEGMTWVRQAPGKGLEWVSTIET6G7VTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKMD6SGTWQTFDYW6QGTLVTVSS (SEQ ID NO： 191) 50-
163920.doc 201245225 BMS3h-298 EVQLLESG6GLVQPGGSLRLSCAASGFrFDSLGM6WARQAP6KGLEWVSYIRAEGAYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKYLADSDYWGQ6TLVTVSS (SEQ ID NO： 192) BMS3h-299 EVQLLESGGGLVQP66SLRLSCAASGFTFSESYMEWVRQAP6K6LEWVSGIDHI66GTYYADSVKGRFTISRDWSKNTL YLQMNSLRAEDTAVYYCAKDDGRGGSMFDYWGQGTLVTVSS (SEQ ID NO: 19B) BMS3h-300 EVQLLESGGGLVQPGGSLRLSCAASGFTFSGGYMWWVRQAPGKGLEWVSSIGASGAYTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKTGGRLDYW6QGTLVTVSS (SEQ ID NO: 194) BMS3h-301 EVQLLESGGGLVQPGGSLRLSCAASGFTFDE6HMGWVRQAPGKDLEWVSYIGSLGLHTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKREFSNGGFDYWGQGTLVTVSS (SEQ ID NO： 195) BMS3h-302 EVQLLESG66LVQPGGSLRLSCAASGFTFKTSPMYWVRQAP6KGLEWVSSIDRTGGHTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKQALLTDAKRFDYWGQGTLVTVSS (SEQ ID NO： 196) BMS3h-303
EVQLLESGG6LVQPG6SLRLSCAASGFTFDGRDM\/WVRQAPGK6LEWVSAISPSGLDTYYAD5VKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAERPQMLVTNFDYWGQGTLVTVSS (SEQ ID NO： 197) BMS3h-B04 EVQLLESGGGLVQPGGSLRLSCMSGFTFGNDPMSWVRQAP6KGLEWVSGIGRE6DSTYYADSVKGRFTISRDNSKNTI YLQMNSLRAEDTAVYYCAKDSMRHQPFDYWGQGTLVTVSS (SEQ ID NO： 198) BMS3h-305 EVQLLESG6GLVQPGGSLRLSCAAS6FTFDETYMKWVRQAPGKGLEWVSAIGASGADTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKFTHLN6RFDYWGQGTLVTVSS (SEQ ID NO: 199) BMS3h-306 EVQUESGG6LVQPGGSLRLSCAAS6FTFGGWPMGWVRQAPGKGLEWVSGIDIDGAPTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEEA6SWSFDYWGQGTLVTVSS (SEQ ID NO： 200) BMS3h-307 EVQLLESGGGLVQPGGSLRLSCAASGFTFSDQAMIaIWARQAPGKGLEWVSFIQGDGGFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKPSKPFDYVIGQGTLVTVSS (SEQ ID NO： 201) BMS3hr308 EVQLLES6GGLVQP6GSLRLSCAAS6FTFETGQMGWARQAPGKGLEWVSNIDGS6TYTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKAVRNFAFDYWGiJGTLVTVSS (SEQ ID NO: 202) BMS3h-309 EVQLLESGGGLVQPGGSLRLSCAASG(;TFSGHDMSWVRQAPGKGLnWVSAISPH6THTYYADSVKGRFTISRDNSKNTL YLQMIsISLRAEDTAVYYCAKGIRGWIGHDTQPFDYWGQGTLVTVSS (SEQ ID NO： 203) •51· 163920.doc 201245225 BMS3h-310 EVQLLESGGGLVQPGGSLRLSCAAS6FTFESKDMLWVRQAP6KGLEWVSSI5SDGTHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAQELG6SWQFDYWGQGTLVTVSS (SEQ ID NO: 2Θ4) BMS3h-311 EVQtLES6GGLVQPGGSLRLSCAASGFTFADRDMVWVRQAP6KGLEWVS6I6AS6TSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDAAVYYCAKGG丫GPTDLWDFDYWGQGTLVTVSS (SEQ ID WO: 205) BMS3h-312 EVQLLESGGGLVQPGGSLRLSCAASGFTFDDEKMLWVRQAPGKGLEWVSSISVS6LHTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEEAGSWSFOYWGQGTLVTVSS (SEQ ID NO： 206) BMS3K-313 EVQLLES6GGLVQPGGSLRLSCAASGFTFGQERMIWVRQAP6K6LEWVSDISAS6GTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEEAGSWSFDYWGQ6TLV7VSS (SEQ ID NO: 207) BMS3H-37-1 EVQLLESGGGLVQPGGSLRLSCAASGFTFEWYEMQWRQAPGKGLEWVSAISGDGYRTYYADSVKGRFTISRDNSMNTL YLQMNSLRAEDTAVYYCAKEL6YFDYR6R6TLVTV55 (SEQ ID NO: 208) BMS3h-37-2 EVQLLESGGGLVQPGGSLRLSCAASGFTFEWYEMQWVRRAPGKGLEWVSAISGDGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELGYFDYWGR6TLVTVSS (SEQ ID NO； 209)
BMS3h-B7-B EVQLLESGGGLVQP66SLRLSCAAS6FTFEWYEMQWVRRAPGKGLEWVSAIS6D6YRTyYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEL6YFDYRVQ6TLVTVSS (SEQ ID NO: 210) BMS3h-37-4 EVQLLESGGGLVQPG6SLRLSCAASGFTFEWYEMQWVRKAPGKGLEWVSAIS6DGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEL6YFDYW6RGTLVTVSS (SEQ ID NO: 211) BMS3h-37-5 EVQLLESGG6LVQPGGSLRLSCAASGFTFEWYEMQWVRQAPGKGLEWISAIS<3DGYRTYYAOSVK<3RFTISRONSKNTL YLQMNSLRAEDTAVYYCAKELGYFDYRVQGTLVTVSS (SEQ ID NO： 212) BMS3h-37-6 EVQLLESGG6LVQPGGSLRLSCAASGFTFEWYEMQWVRRAP6KGLEWVSAIS6DGYRTYYADSVKGRFTISRDNSENTL YLQMNSLRAEDTAVYYCAKELGYFDYWGRGTLVTVSS (SEQ ID NO： 213) BMS3h-37-7 EVQLLETGG6LVQPGGSLRLSCAASGFTFEWYEMQWVRRAP6KGLEWVSAISGD6YRTYYADSVKGRFTISRDNSKNTL YLQMDSLRAEDTAVYYCAKELGYFDYWGRGTLVTVTS (SEQ ID NO: 214) BMS3h-37-8 EVQLLESGGGLVQPGG5LRLSCAASGFTFEWYEMQWVRQAP6K6LEWVSAISGD6YRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEL6YFHYW6RGTLVTVSS (SEQ ID NO: 215) BMS3h-37-9 EVQLLES6GGLVQP6GSLRLSCVASGFTFEWYEMQWVRQAPGNGLEWISAIS606YRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEL6YFDYWGRGTLVTVSS (SEQ ID NO: 216) -52- 163920.doc 201245225 BMS3h-37-10 EVQLLESG6GLVQPG6SLRLSCAAS6FTFEWYEMQWVRRAP6K6LEWVSAISG0GYRTYYADSVKGRFTISRDNSKNTL YLLMNSLRAEDTAVYYCAKELGYFDYWSR6TLVTVSS (SEQ ID NO: 217) BMS3h-B7-ll EVQLLESGGGLVQPGGSLRLSCAASGFTFEWYEMQWVRKAP6K6LEWVSAIS6DGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVyYCAKELGYFDYRGRGTLVTVSS (SEQ ID NO: 218) BMS3h-37-12 EVQLLESGG6LVQP6GSMRLSCAASGFTFEWYEMQWVRRAP6KGLEWVSAISGDGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEL6YFDVRGR6TLVTVSS (SEQ ID NO: 219) BMS3h-37-201 EVQLLESGGGLVQPGGSLRLSCAASGFTFEWYEMQWVRRAPGKGLEWVSMISGDGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELGYFDYWGRGTLVTVSS (SEQ ID NO: 220) BM53h-37-262 EVQLLES6GGLVQPGGSLRLSCAASGFTFEWYEMQWVRRAPGKGLEWVSAI5GDGWRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELGYFDYWGRGTLVTVSS (SEQ ID NO： 221)
BMS3h-37-20B
EVQLLES6GGLVQP6GSLRLSCAASGFTFGWYEMQWVRRAPGKGLEWVSAIS6DGYRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEOTAVYYCAKELLYFDYWGRGTLVTVSS (SEQ ID NO: 222) BMS3h-37-204 EVQLLESGGGLVQPGGSLRLSCAASGFTFEMYEMQWVRRAPGKGLEWVSAISGDGYRTYYADSVKGRFnSRDNSKNTL YLQMNSLRAEDTAWYCAKELGFFDYUGRGTLVTVSS (SEQ ID NO： 223) BMS3h-B7-205 EVQLLESGGGLVQP66SLRLSCAASGFTFEMYEMQWVRRAPGKGLEWVSAIS6DGYRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELEYFOYIsGRGTLVTVSS (SEQ ID NO： 224) BMS3h-37-206 EVQLLESGGGLVQPGGSLRLSCAASGFTFEWYEMQWVRRAPGKGLEWVSAISGDGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKGLEVFDYWGRGTLVTVSS (SEQ ID NO： 225) BMS3h-37-207 EVQLLESG6GLVQPGGSLRLSCAASGFTFEWYEMQWVRRAPGKGLEWVSAIS6D6YRTYYADSVKGRFTI5RDNSKNTL YU^INSLRAEDTAVYYCAKELAFFDYVIGRGTLVTVSS (SEQ ID NO: 226) BMS3h-37-208 EVQLLESGGGLVQPGGSLRL5CAASGFTFEWYEMQWVRRAPGKGLEWVSAISGDGYRTYYADSVKGRFTISRDNSKNTL YL(yiNSLRAEDTAVYYCAKELLYFDYUGRGTLVTVSS (SEQ ID NO: 227) BMS3h-37-2 的 EVQLLES6GGLVQPGGSLRLSCAASGI:TFEWYEMQWVRRAf>GK6LEWVSAISGDGYRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELEFFDYWGR6TLVTVSS (SEQ ID NO： 228) 53- 163920.doc 201245225 BMS3h-37-210 EVQLLESGGGLVQP66SLRLSCAASGFTFEWYEMQWVRRAPGK6LEWVSAISGDGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELQFFDYWGRGTLVTVSS (SEQ ID NO： 229) BMS3h-37-211 EVQLLESGG6LVQPGGSLRLSCAASGFTFEWYEMQWVRRAPGK6LEWVSAIS6D6YRTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKELLFFDYWGR6TLVTVSS (SEQ ID NO： 23Θ) BMS3h-37-212 EVQLLESG6GLVRPGGSLRLSCMSGFTFEWYEMQWVRRAPGKGLEWVSAIS6DGYRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELEFFDYW6RGTLVTVSS (SEQ ID NO: 231) BMS3H-37-213 EVQLLESGG6LVQPGGSLRLSCAAS6FTFEWYEMQWVRRAP6KGLEWVSAISGDGYRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELLFFDYRGRGTLVTVSS (SEQ ID NO： 232) ' BMS3h-37-214 EVQLLES6GGLVQPGGSLRL5CAA5GFIFEWYEMQWVRRAPGKGLEWVSAISGDGYRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKNLEYFDYWGRGTLVTVSS (SEQ ID NO： 233) BMS3h-37-215 EVRLLESG6GLVQPG6SLRLSCAAS6FTFEWYEMQWVRRAP6KGLEWVSAISGD6YRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKELQFFDYWGRGTLVTVSS (SEQ ID NO: 234) BMS3h-38-l EVQLLGSGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTL YU^INSLRAEOTAVYYCSKEPFRFDYWGQOTLVTVSS (SEQ ID NO： 235) BMS3h-38-2 EVQLLASGGGLVQP6GSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISGS66STYYA0SVKGRFTISRDNSKNTL YLQMNSLRAE0TAVYYC6KEPFRYDYWGQGTLVTVSS (SEQ ID NO： 236) BMS3h-38-3 EVQLUSGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAP6K6LEWISAISGSGGSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRFDYWGQGTLVTVSS (SEQ ID NO： 237) BMS3h-38-4 EVQLLDP66GLVQPGGSLRLSCAASGFTFGKEEMIWVRQAPGKGLEWVSSISGSGGSTYYADSVKGRFTISRDNSRNTL YLQMNSLRAEDTAVYYCGKEPFRFDYWGQGTLVTV5S (SEQ ID NO: 238) BMS3h-38-5 EVQLLGSGG6LVQP6GSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRFDYWGQ6TLVTVSS (SEQ ID NO： 239) BMS3h-38-6 EVQLLEPGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTL YLLMNSLRAEDTAVYYCSKEPFRFDYWGQGALVTVSS (SEQ ID NO: 240) BMS3h-38-7 EVQLLDPG6GLVQPGGSLRLSCAAS6FTF6KEEMIWVRQAPGK6LEWVSSIS6SG6STYYADSVK6RFTISRDNSKNTL YU^INSLRAEDTAVYYCAKEPLRFDYWGQGTLVTVSS (SEQ ID NO： 241) 54·
163920.doc 201245225 BMS3h-38-8 EVQLLES6G6LVQPG6SLRLSCAASeFTFEEEEMIWVRQAP6KGLEWISAISGS6GSTYYADSVK6RFTIHRDNSKNTL YLQMNSLRAEDTAVYYCSKEPFRFDVRGLGTLVTVSS (SEQ ID NO： 242) BMS3h-38-9 EVQLLDPG6GLVQPGGSLRLSCAASGFTFGKEEMIWVRQAPGKGLEWVS5ISGSGGSTYYADSVKGRFTISRDNSRNTL YLQMNSLRAEDTAVYYCAKEPLRFDVWGQGTLVTVSS (SEQ ID NO: 243) BMS3h-38-10 EVQLLDSGG6FVQPG6SLRLSCMS6FTFEEEEMIWVRQAPGKGLEWISAISGSGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEOTAVYYCAKEPFRFDYWGQGTLVTVSS (SEQ ID NO: 244) BMS3h-B8-ll EVQLLDPGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGK6LEWISAIS6S66STYYADSVKGRFTISRDNSNNTL YLQMNSLRAEDTAVYYCGREPFRFDYW6QGTLVTVSS (SEQ ID NO： 245) BMS3h-38-12 EVRLLESGEGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAP6KGLEWVSAIS6SGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRFDYWGQGTLVTVSS (SEQ ID NO： 246) BMS3h-38-13
EVQQLESG6GLVQPGGSLRLSCMSGFTFEEEEMIWVRQAPGKGLEWVSAIS6SGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRFDYWGQGTLVTVSS (SEQ ID NO： 247) BMS3h-38-201 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISGS6GSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFYYDYaIGQGTLVTVSS (SEQ ID NO： 248) BMS3h-38-202 EVQLLASGGGLVQPGGSLRLSCAAS6FTFEEEEMIWVRQAPGK6LEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFYFDYWGQGTLVTVSS (SEQ ID NO： 249) BMS3h-38-203 EVQLLASGGGLVQPG6SLRLSCAASGFTFEEKEMIWVRQAPGK6LEWVSAIS6S6GSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFFYDWGQGTLVTVSS (SEQ ID NO： 250) BMS3h-38-204 EVQLLASGGGLVQPGGSLRLSCAASGFTFPQEEMIWVRQAPGKGLEWVSAIS6SGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDY1/JGQGTLVTVSS (SEQ ID NO: 251) BMS3h-38-205 EVQLLASGGSLVQPGGSLRLSCAASGFTFFAAEMIWVRQAPGKGLEWVSAIS6S6GSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYIaIGQGTLVTVSS (SEQ ID NO: 252) BMS3h-38-206 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRPGTSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYI-JGQGTLVTVSS (SEQ ID NO： 253) -55- 163920.doc 201245225 BMS3h-38-207 EVQLLASGGGLVQPGGSLRLSCAA5GFTFEEEEMIWVRQAPGKGLEWVSAISRMGFSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQ6TLVTVSS (SEQ ID NO： 254) BMS3h-38-208 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRWGHSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 255) BMS3h-38-209 EVQLLASGGGLVQPG65LRLSCAAS6FTFEEEEMIWVRQAPGK6LEWVSAISRLGWSTYYAOSVKGRFTISRDNSKNTL YLQMNSLRAE0TAVYYCGKEPFRYDYWGQ6TLVTVSS (SEQ 10 NO: 256) BMS3H-38-210 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIUVRQAPGKGLEWVSAISRWGASTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO： 257)
BMS3h-38-2U EVQLLASG6GLVQPGGSLRLSCAASGFTFEEEEMIWVRQAP6K6LEWVSAISRQ6GSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYC6KEPFRYDYWGQGTLVTVSS (SEQ ID NO： 258) BMS3h-38-212 EVQLLAS6GGLVQPG6SLRLSCAAS6FTFEEEEMIWVRQAP6K6LEWVSAISVSGWSTYYADSVKGRFTISRDNSKNTL YLQMWSLRAEDTAVYYC6ICEPFRYDYWGQGTLVTVSS (SEQ ID NO： 259) BMS3h-38-213 EVQLLASG66LVQPGGSLRLSCAAS6FTFEEEEMIWVRQAP6K6LEWVSAISRW6WSTYYADSVKGRFTISRDNSKNTL YL(^SLRA£DTAVYYCGKEPFRYDYWGQCTLVTVSS (SEQ ID NO: 26β> BMS3h-38-214 EVQLLASG6GLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGLSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO： 261) BMSBh-38-215 EVQLLASGGGLVQPGGSLRLSCAAS6FTFEEEEMIWVRQAPGKGLEWVSAISGL6WSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDVWGQGTLVTVSS (SEQ ID NO： 262) BMS3H-38-216 EVQLLASG6GLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISALGWSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO： 26B) BMS3h-38-217 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRRGYSTYYADSVKGRFTISRONSKNTL YK^INSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO： 264) BMS3h-38-218 EVQLLASGGGLVQPGGSLRLSCAAS6FTFEEEEMIWVRQAPGK6LEWVSAISRHGWSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 265) BMS3h-38-219 EVQLLAS66GLVQPG6SLRLSCAAS6FTFEEEEMIWVRQAP6KGLEWVSSISRSGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO： 266) 56· 163920.doc 201245225 BMS3h-38-22d EVQLLASGGGLVQPG6SLRLSCAAS6I:TFEEEEMIWVRQAPGKGLHWVSAISRIGNSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYiJGQGTLVTVSS (SEQ ID NO： 267) BMS3h-B8-221 EVQLLASGGGLVQPGGSLRLSCAASGITFEEEEMIWVRQAPGKGLEWVSAISGHGWSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYIJGQGTLVTVSS (SEQ ID NO: 268) BMS3h-38-222 EVQLLASG66LVQPGGSLRLSCAAS6I:TFEEEEMIWVRQAPGKGLEWVSAISRWGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYC6KEPFRYDYWGQGTLVTVSS (SEQ ID NO： 269) BMS3h-38-223 EVQLLASGGGLVQPGGSLRLSCMSGITFEEEEMIWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKMTL YLQMNSLRAEDTAVYYCGKEPFMYDYtJ6Q6TLVTVSS (SEQ ID NO： 27Θ) BMS3h-38-224 EVQLLASGGGLVQPGGSLRLSCAASG!:TFEEEEMIWVRQAP6KGLEW\^AIS6SGGSTYYADSVK6RFTISR0NSKNTL YLQMNSLRAEDTAVYYCGKEPFPYDYWGQGTLVTVSS (SEQ ID NO： 271) BM53h-38-225
EVQLLASG6GLVQPG6SLRLSCAAS6I:TFEEEEMIWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYVK3QGTLVTVSS (SEQ ID NO： 272) BMS3h-38-226 EVQLLASGGGLVQPGGSLRLSCAASGfTFEEEEMIWVRQAPGKGLEWVSAISGSGGSTYYAOSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPLYYDYlfGQGTLVTVSS (SEQ ID NO: 273) BMS3h-38-227 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEW^AISGSGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPMYYDYVK5QGTLV7VSS (SEQ ID NO： 274) BMS3h-38-228 EVQLLASGGGLVQPG6SLRLSCAAS6f:TFEEEEMIWVRQAP6KGLEWV5AISRNGFSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYliGQGTLVTVSS (SEQ ID NO： 275) BMS3h-38-229 EVQLLAS6GGLVQPG6SLRLSCAASGi:TFEEEEMIWVRQAPGK6LEWVSAI5RTG6STYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYC6KEPFRYDYliGQGTLVTVSS (SEQ ID NO: 276) BMS3h-38-230 EVQLLASGGGLVQPGGSLRLSCAASGI:TFEEEEMIWVRQAPGKGLIEWVSAISREGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYIJGQGTLVTVSS (SEQ ID NO: 277) BMS3h-38-231 EVQLLASGGGLVQPGGSLRLSCAASGI:PFEEEEMIWVRQAPGK6LEWVSAISRQGWSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYUGQGTLVTVSS (SEQ ID NO： 278) •57· 163920.doc 201245225 BMS3h-B8-232 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRGGGSTYYADSVKGRFTISRONSKNTL YLQMNSIRAEDTAVYYCGKEPFRYDYWGQ6TLVTVSS (S6Q ID NO: 279) BMS3H-38-233 EVQLLASGGGLVQP6GSLRLSCAAS6FTFEEEEMIWVRQAP6K6LEWVSAISRTGYSTYYADSVKGRFTISR0NSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO： 280) BMS3h-38-234 EVQLLASG6GLVQP66SLRLSCAASGFTFEEEEMIWVRQAP6KGLEWVSAISRNGRSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYW6咴TLVTVSS (SEQ ID NO: 281〉 BMS3h-38-235 EVQLLAS6GGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGK6LEWVSAISRNGYSTYYADSVKGRFTISRDNSKNTL YUJMNSLRAEDTAWYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 282) BMS3H-38-236 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGK6LEWVSAISRKGSSTVYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO： 283) BMS3H-38-237 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAP6KGLEWVSAISR6GWSTYYA0SVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQ6TLVTVSS (SEQ ID NO： 284) BMS3h-38-238 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRSGYSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ 10 NO： 285) BMS3h-38-239 EVQLLASG6GLVQPGGSLRLSCAASGFTFEEEEMIWVRQAP6K6LEWVSAISRN6MSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYC6KEPFRYDYW6QGTLVTVSS (SEQ ID NO： 286) BMS3h-38-240 EVQLLESGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 287) BMS3h-41-l EVQLLES6EGLVQP6GSLRLSCAASGFTFTEHEMIWVRQAPGK6LEWVSSIS6NGANTYYADSVK6RFTISRDNSKNTL YLQMNSLRPEDTAVYYCAKEPLRFDYWGQGTLVTVSS (SEQ ID NO: 288) BMS3h-41-2 EVQLLESGGGLVQPGGSLRLSCAASGSTFTEVEMIWRQAPGKGLEWIS5ISGN6ANTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYFCAKEPLRFDYRGQ6TLVTVSS (SEQ ID NO: 289) BMS3h-41-3 EVQLLEPG6GLVQP6GSLRLSCAASGFTFTEYEMIWVRKAPGKGMEWVSSISGNGANTYYADSVK6RFTISRDNSKNML YLQMNSLRAEDTAVYYCAKEPLRFGYWGQGTLVTVSS (SEQ ID NO: 290) BMS3h-41-4 EVQLLDSG66LVQPG6SLRLSCAASGFTFTEYEMIWVRQAPGKGLEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDYWGRGTLVTVSS (SEQ ID NO： 291) 58-
163920.doc 201245225 BMS3h-41-5 EVQLLGSGGGLVQPGGSLRLSCAASGFTFTEYEMIWVRQAPGKSLEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRYDDUGQGTLVTVSS (SEQ ID NO： 292) BMS3h-41-6 EVQPLES66GLVQPG6SLRLSCSASGFTFNEYEMIWVRQAPGK6LEWVSSISGN6ANTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDYUGQGTLVTVSS (SEQ ID NO： 293) BMS3h-41-7 EVQLLESGEGLVQPG6SLRLSCAASGFTFAEYEMIWVRQAPGKGLEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDYUGQGTLVTVSS (SEQ ID NO： 294) BMS3H-41-8 EVQLLDPGGGLVQPGGSLRLSCAASGFTFTESEMIWVRQAPGKGLEWVSSIS6NGANTYYADSVK6RFTISRDNSKNTL YL(yiNSLRAEDTAVYYCAKEPLRFDY^GQGTLVTVSS (SEQ ID NO： 295) BMS3h-41-9 EVQLLEPGGGLVQPGGStRLSCAASGFTFTEYEMIWVRKAPGKGMEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRPEDTAVYYCAKEPLRFDDKGQ6TLVTVSS (SEQ ID NO: 296) BMS3h-41-10
EVQLLESGVGLVQPGGSLRLSCAASGFTFTEYEMIWVRKAP6KGLEWVSSIS6N6ANTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDNKGQGTLVTVSS (SEQ ID NO； 297) BMS3h-41-ll EVQLLESRGGLVQPGGSLRLSCAASGF 了 FTEHEMIWVRQAPGKGLEWVSSIS6NGANTYYADSVKGRFSVSRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDYKGQ6TLVTVSS (SEQ ID NO： 298) BMS3h-41-12 EVQPLESGGGLVQPGGSLRLSCAASGFTFTEYEMIWVRQAP6K6LEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDYWGQGTLVTVSS (SEQ ID NO： 299) BMS3H-41-13 EVQLLESAGGLVQPGGSLRLSCAASGFTFAEYEMIWVRQAPGKGLEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDYWGQGALVTVSS (SEQ ID NO： 300) BMS3h-41-14 EVQLLEPGGGLVQPGGSLRLSCAASGFTFTEYEMIWVRQAPGKGLEWVSSISGNGANTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPLRFDNKGQ6TLVTVSS (SEQ ID NO： 301) BMS3H-43-1 EVQLLES6GGLVQPGGSLRLSCTASGFTFNMYEMSWVRQAPGKGLEWVS6ISRRGFTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPITYDLRYARFDYSGQGTLVTVSS (SEQ ID NO： 302) BMS3h-43-2 EEQLLESGGGLVQPGGSLRLSCTASGFTFNMYEMSWVRQAPGKGLEWVSGISRRGFTTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKEPITYATRYARFDYWGQGTLVTVSS (SEQ ID NO： 303) 59· 163920.doc 201245225 BMS3h-43-3 EVQLLES6GGLVQPGGSLRLSCTASGFTFNMYEMSWVRQAP6KGLEWVSGISRRGFTTYYADSVKGRFTISRDMFKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARFDYGGQ6TLVTVSS (SEQ ID NO： 304) BMS3h-43-4 EVQLLESGGGLVQPGGSLRLSCTASGFTFNMYEMSWVRQAPGKGLEWVSGrSRRGFTTYYADSVKGRFTISRDMSKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARFDNWGQGTLVTVSN (SEQ ID NO： ΒΘ5) BMS3h-43-5 EVQLLESGGGLVQPGGSLRLSCTASGFTFNTYEMSWVRQAPGKGLEWVSGIGRRGFTTYYADSVKGRFTISRDMSKNTL YLQMNSLRAEDTAVYYCAKEPITYDLRYARFDYSGQ6TLVTVSS (SEQ ID NO： 306) BMS3h-43-6 EVQLMESGG6LVQPGGSLRL5CTAS6FSFNMYEMSWVRQAPGK6LEWVSGISRRGYTTYYADSVK6RFTXSR0NSKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARFDYW6R6TLVTVSS (SEQ ID NO: 307) BMS3h-43-7 EVQLLESG6GLVQPGGSLRLSCTASGFAFNMYEMSWVRQAPGKGLEWVSGISRHGFTTYYADSVKGRFTVSRDWSKNTL YLQMNSLRAEDTAVYYCAKEPITYOMRYARSDYWGQGTLVTVSS (SEQ ID NO: 308). BMS3h-43-8 EVQLLESGG6LVQPG6SLRLSCTAS6FTFNMYEMSWVRQAPGKGLEWVSGISRRGFT7YYADSVK6RFTISRDNSKNTL YUyiNSLRAEDTAWFCAKEPITYDMRYARSDYWGQGTLVTVSS (SEQ ID NO： 309) BMS3h-43-9 EVQLLESGGGLVQPG6SLRLSCTASGFTFNMYEMSWVRQAP6K61EWVSGISRRGFTTYYADSVKGRFTISRDN5KNTL YLQMNSLRAEDTAVYYCAKEPITYSMRYARFDYSGL6TMVTVSS (SEQ ID NO: 310) BMS3h-43-10 EVQLLESGGGLVQPGGSLRLSCTASGFTFNMYEMSWVRQAPGKGLEWVSeiSRRGFTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARF0YSGQ6TLVTVSS (SEQ ID NO: 311) BMS3h-43-ll EVQLLESGGGLVQPGGSLRLSCTASGFTFNMYEMSWVRKAPGK6LEWVSGISRH6FTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARFDYWGQGTLVTVSS (SEQ 10 NO： 312) BMS3h-43-12 EVQLFESGGGLVQPGGSLRLSCTASGFTFNMYEMSWVRQAPGKGLEWVSGISRRGFTTYYADSVKGRFTISRDMSKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARFDYWGRGTLVTVSS (SEQ ID NO： 313) BMS3h-43-13 EVQLLES6GGLVQPG6SLRLSCTASGFTFNMYEMSWVRQAPGK6LEWVSGISRRGFTTYYADSVK6RFTI5RDNSKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARFDYWGR6TLVTVSS (SEQ ID NO: 314) BMS3h-43-14 EVQLLES6GGSVQPG6SLRLSCTASGFSI=NMYEMSWVRQAPGKGLEWVSGISRR6FTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPITYDMRYARFDYWGQGTLVTVS6 (SEQ ID NO： 315) BMS3H-43-15 EVQLLESGGGLVQPGGSLRLSCTASGFTFNMYEMSWVRKAPGKGLEWVSGISRRGFTTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAWYCAKEPITYDMRYARFDYWGQGTLVTVSS (SEQ ID NO: 316) 60· 163920.doc 201245225 BMSBh-56-1 EVQLLESGGGLVQPGGSLRLSCAASGi:TFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVS5 (SEQ ID NO： 317) BMS3h-56-2 EVQLLES6G6LVQPG6SLRLSCAASGfTFRDYEMWWVRQAP6KGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDViGQGTLVTVSS (SEQ ID NO: 318) BMS3h-56-3 EVQLLESGGGLVQPGGSLRLSCAASGfTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEbTAVYYCTKLPFIFEYVIGQGTLVTVSS (SEQ ID NO： 319) BMS3h-56-4 EVQLLESGGGLVQPGGSLRLSCAASGfTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFDDF：GQGTLVTVSS (SEQ ID NO： 320) BMS3h-56-5 EVQLLESGGGLVQP66SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDVIGQGTLVTVSS (SEQ ID NO： 321) BMS3h-56-6
EVQLLESGGGLVQPGGSLRLSCAASGFSFRDVEMUIWYRQAP6KGLERVSAINPQ6TRTYYA0SVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFIFDNF：GQGTLVTVSS (SEQ ID NO： 322) BMS3h-56-7 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAE0TSVYHCAKPPFIF6DHGPGTLVTVSS (SEQ ID NO: B23) BMS3h-56-8 EVQLLESGGGLVQP6GSRRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDHGQGTLVTVSS (SEQ ID NO： 324) BM53h-56-9 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFDDFlGQGTLVTVSS (SEQ ID NO： 325) BMS3h-56-10 EVQLLESGGGLVQP66SLRLSCAASGFTFRDVEMWWVRQAPGKVLERVSAINPQGTRTYYADSVKGRFTISRDNSKNML YLQMNSLRAEDTAVYYCAKLPFMFDDF.GQGTLVTVSS (SEQ ID NO： 326) BMS3h-56-ll EVQLLESGGGLVQP66SLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFDDF.GQGTLVTVSS (SEQ ID NO: 327) BMS3h-56-12 EVQLLESGGGLIQFGGSLRLSCAAS6FTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCLKLPFIFDYVIGQGTLVTVSS (SEQ ID NO： 328) -61 - 163920.doc 201245225 BMS3h-56-13 EVQLLESGGGLVQPGGSLRLSCMSGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRADDTAVYHCTKLPFIFDYW6QGTLVTVSS (SEQ ID NO： 329) BMS3h-56-14 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGMVLERVSAINPQ6TRTYYAD5VKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFFFDSRGQ6TLVTVSS (SEQ ID NO: 330) BMS3h-56-15 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRRAP6KGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO: 331) BMS3h-56-16 EVQLLES66GLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAWYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 332) BMS3h-56-17 EVQLLES6GGLVQPGGSLRLSCAASGFSFRDYEMWWYRQAP6KGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 333) BMS3h-56-18 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKVLERVSAINPQGTRTYYADSVKGRFTISRDNSKNML YUQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 334) BMS3h-56-19 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6K6LERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPFTFEDWGQGTLVTV5S (SEQ ID NO： 335) BMS3h-56-20 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPQ6TRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCTKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 336) BMS3h-56-21 EVQLLESGG6LVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCLKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 337) BMS3h-56-22 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRADDTAVYHCTKLPFIFEVW6QGTLVTVSS (SEQ ID NO: 338) BMS3h-56-23 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPYSFDSWGQGTLVTVSS (SEQ ID NO： 339) BMS3h-56-24 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVMGRFTISRONSKNTL YLQMNSLRAEDTAVYHCAKEPYSYDYWGQGTLVTV5S (SEQ ID NO： 340) BMS3H-56-25 EVQLLES6GGLVQPGGSLRLSCAASGFTFRDYEMWWVRRAP6KGLERVSAINPQ6TRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDWGQGTLVTVSS (SEQ ID NO： 341) 62-
163920.doc 201245225 BMS3h-56-26 EVQLLESG6GLVQPG6SLRLSCAASGFTFRDYEMWWVRRAP6K6LERVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFDDUGQGTLVTVSS (SEQ ID NO： 342) BMS3h-56-27 EVQLLESGGGLVQP66SLRLSCAASGI:TFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFDDWGQ6TLVTVSS (SEQ ID NO： 343) BMSBh-56-28 EVQLLESG6GLVQPGGSLRLSCAASGI:TFAGYELWWVRQAPGK6LLrRVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAmCAKLPFTFDDWGQGTLVTVSS (SEQ ID NO: 344) BMS3h-56-29 EVQLLESGGGLVQPGGSLRLSCAASGI:TFAGYEL1aIWVRQAPGK6LI:RVSAINPQGTRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFDDUGQGTLVTVSS (SEQ ID NO： 345) BMS3h-56-30 EVQLLESGGGLVQPG6SLRLSCAAS6f:TFAGYEMWWFRQAP6KGLERVSAINPQ6TRTYYADSVHGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDWJGQGTLVTVSS (SEQ ID NO: 346) BMS3h-56-31
EVQLLESGGGtVQPGGSLRLSCAASGITFAGYEMWWFRQAPGKGLERVSAINPQGTRTYYADSVMGRFTISRDNSICNTL YLQMNSLRAEDTAVYYCAKLPFMFDDf：GQGTLVTVSS (SEQ ID NO: 347) BMS3H-56-B2 EVQLLESGGGLVQPGGSLRLSCAASGfTFRDYEMWWVRQAPGKGLEWVSAINPQGTRTYYADSVMGRFTISRDNSICNTL YLQMNSLRAEDTAVYYCAKLPFTFDDW6Q6TLVTVSS (SEQ ID NO; 348) BMS3h-56-B3 EVQLLESGGGLVQPGGSLRLSCAAS6FTFRDYEMWWVRQAP6K6LEWVSAINPQ6TRTYYADSVMGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFDDF：GQ6TLVTVSS (SEQ ID NO： 349) BMS3h-56-202 · EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPTYFSDF.GQGTLVTVSS (SEQ ID NO： 350) BMS3h-56-203 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFFFEEIftIGQGTLVTVSS (SEQ ID NO： 351) BMS3h-56-204 EVQLLESG66LVQPG6SLRLSCAAS6FTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPTYFKD1«IGQGTLVTVSS (SEQ ID NO： 352) BM$3h-56-205 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQ6TRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFSEWGQGTLVTVSS (SEQ ID NO: 353) 63· 163920.doc 201245225 BMS3h-56-206 EVQLLES6GGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVK6RFTISRDN5KNTL YLQMNSLRAEDTAVYHCAKLPMFFEDWGQGTLVTVSN (SEQ ID NO: 354) BMS3h-56-207 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPQGTRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFPFSEW6QGTLVTVSS (SEQ ID NO: 355) BMS3h-S6-208 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMDSLRAEDTAVYYCAKLPFYFSEWGQGTLVTVSS (SEQ ID NO: 356) BMS3h-56-209 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPYGNLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 357) BMS3h-56-210 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPPGTLTYYADSVKGRFnSRbNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDRGQGTLVTVSS (SEQ ID NO： 358) BMS3h-56-211 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPWGGLTYYADSVK6RFTISR0NSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 359) BMS3h-56-212 EVQLLESGGGLVQPGGSLRL5CAASGFTFRDYEMWWVRQAPGKGLERVSAINPMG6FTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 36Θ) BMS3h-56-213 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPWGSHTYYAD5VK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO: 361) BMS3h-56-214 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPSGGLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDRGQGTLVTVSS (SEQ ID NO： 362) BMS3h-56-215 EVQLLE5GGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERV5AINPHGSLTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDWGQGTLVTVSS (SEQ ID NO： 36B) BMS3h-56-216 EVQLLES66GLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPAGRLTYYAOSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 364) BMS3h-56-217 EVQLLESGGGLVQPGGSLRLSCAAS6FTFRDYEMWWVRQAPGK6LERVSAINPWGSLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 365) BMS3h-56-218 EVQLLESGGGLVQPGGSLRLSCAAS6FTFPDYEMWWVRQAPGK6LERVSAINPQ6TRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPFTFDDWGQ6TLVTVSS (SEQ ID NO： 366) 64-
163920.doc 201245225 BMS3h-56-219 EVQLLESG6GLVQPG6SLRISCADS6ITFPPVEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTYSS (SEQ ID NO： 367) BMS3h-56-220 EVQLLESG6GLVQPGGSLRLSCAASGITFRDYEMWWVRQAP6KGLERVSAINPYGGLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDVJGQGTLVTVSS (SEQ ID NO： 368) BMS3h-56-221 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPWGNHTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 369) BMSBh-56-222 EVQLLESGGGLVQPGGSLRLSCAASGfTFRDYEMWWVRQAPGKGLERVSAINPHGGYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEOflGQGTLVTVSS (SEQ ID NO： 370) BMS3h-56-223 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGRGLERVSAINPPGMLTYYA0SVK6RFTISRDNSKNTL YL®«1NSLRAEDTAVYYCAKLPFTFDDWGQGTLVTVSS (SEQ ID NO： 371) BMS3H-56-224
EVQLLESGGGLVQPGGSLRLSCAASGfTFRDYEMWWVRQAPGKGLERVSAINPWGQLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID MO: 372) BMS3H-56-225 EVQLLESeGGLVQP66SlRLSCAASGFTFRDYEMUWVRQAP6KGLERVSAINPW66YTYYADSVKGRFTISRDNSKNTL YLQIWSLRAEDTAVYYCAKLPFTFDDWGQ6TLVTVSS (SEQ ID NO： 373) BMS3h-56-226 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPSGGLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEtM\GQGTLVTV5S (SEQ ID NO： 374) BMS3h-56-227 EVQLLESGGGLVQP66SLRLSCAASGFTFRDYEMWWVRQAP6K6LERVSAINPSGGLTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDUGQGTLVTVSS (SEQ ID NO： 375) BM53H-56-228 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPSGTLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDU6Q6TLVTVSS (SEQ ID NO: 376) BMS3H-56-229 EVCJLLESGGGLVQPGGSLRLSCMSGFTFRDYEMWWVRQAPGKGLERVSAINPYGSLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDIftGQGTLVTVSS (SEQ ID NO: 377) BMS3h-56-230 EVQLLESGG6LVQPGGSLRLSCAAS6FTFRDYEMWWVRQAPGK6LERVSAINPWGGYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDKGQGTLVTVSS (SEQ ID NO： 378) 65- 163920.doc 201245225 BMS3h-56-2Bl EVQLLESGG6LVQPGGSLRLSCAAS6FTFRDYEMWWVRQAPGKGLERVSAINPQ6GLTYYADSVKGRFTISRDNSKNTL YL(»WSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 379) BMS3h-56-232 EVQLLES6GGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPWGSHTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDWGQGTLVTVSS (SEQ ID NO: 380) BMS3h-56-233 EVQLLES666LVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPWGTLTYYADSVK6RFTISRDNSRNTL YLQMNSLRAEOTAVYYCAKLPFTFDDWGQGTLVrVSS (SEQ ID NO: 381) BMS3h-56-234 EVQLLESGGGLVQPGGSLRLSCAAS6FTFRDYEMWWVRQAPGK6LERVSAINPN6RLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFADWGQGTLVTVSS (SEQ ID NO: 382) BMS3h-56-235 EVQLLESGG6LVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPWGQLTYYADSVKGRFTISRDMSKNTL YLQMNSLRAEDTAVYYCAKLPFTFD0W6QGTLVTVSS (SEQ ID NO： B83) BMS3h-56-236 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPHGGLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDWGQ6TLVTVSS (SEQ ID NO: 384) BMS3h-56-237 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINFA6MLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDW6QGTLVTVSS (SEQ ID NO： 385) BMS3h-56-238 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPHGTLTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO: 386) BM53K-56-239 EVQLLESGG6LVQP6GSLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPW6SLTVYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDW6QGTLVTVSS (SEQ ID NO： 387) BMS3h-S6-240 YLQMNSLRAEDTAVYYCAKLPFTFEDWGiJGTLVTVSS (SEQ ID NO： 388) BMS3h-56-241 EVQLLE56GGLVQPGGSLRLSCAAS6FTFRDYEMWWVRQAP6K6LERVSAINPAGFLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 389) BMS3h-56-242 EVQLLESGGGLVRPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPYGGLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 390) BMS3h-56-243 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPWGGFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQ6TLVTVSS (SEQ ID NO： 391) 66·
163920.doc 201245225 BMS3h-56-244 EVQLLESGGGLVQPG6SLRLSCAAS61=TFRDYEMWWVRQAPGKGLERVSAINPWG6LTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDWGQGTLVTVSS (SEQ ID NO： 392) BMSBh-56-245 EVQLLES6GGLVQPG6SLRLSCAASGI-TFRDYEMWWVRQAPGKGLERVSAINPYG6LTYYADSVKGRFTISR0NSKNTL YLQMDSLRAEDTAVYYCAKLPFTFEDNGQGTLVTVSS (SEQ ID NO： 393) BMS3h-S6-246 EVQLLES6GGLVQPG6SLRLSCAASGI:TFRDYEMWWVRQAP6KGLERVSAINPWGTLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWQJ6TLVTVSS (SEQ ID NO: 394) BMS3h-56-247 EVQLLESG6GLVQPG6SLRLSCAAS6I:TFRDYEMWWVRQAP6KGLERVSAINPWGGYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDIJGRGTLVTVSS (SEQ ID NO： 395) BMS3h-56-248 EVQLLESGGGLVQPGGSLRLSCAASGiTFRDYEMWWVRQAPGKGLERVSAINPYGNLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDWJGQGTLVTVSS (SEQ ID NO： 396) BMS3h-56-249
EVQLLESGGGLVQPGGSLRLSCAASGITFR0YEMWWVRQAPGK6LERVSAINPH6GFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEDWGQGTLVTVSS (SEQ ID NO： 397) BMS3h-56-250 EVQLLESGGGLVQPGG5LRLSCAASGiTFRDYEMWWVRQAP6KGLERVSAINPAGFYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFDDUGQGTLVTVSS (SEQ ID NO： 398) BMS3h-56-251 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPAG6LTYYADSVK6RFTISRDNSICNTL YLQMNSLRAEDTAVYYCAKLPFTFDDVIGQ6TLVTVSS (SEQ ID NO： 399) BMS3h-56-252 EVQLLESGGGLVQPGGSLRLSCAASGfAFRDYEMWWVRQAPGKGLERVSAINPHGSLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFTFEWKaQGTLVTVSS (SEQ ID NO： 400) BMS3h-56-253 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPAG6YTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPFTFEDW6Q6TLVTVSS (SEQ ID NO： 401) BMS3h-56-254 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLCyiNSLRAEDTAVYYCAKLPFWFTEUGQGTLVTVSS (SEQ ID NO： 4C2) BMS3h-56-255 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFMFSDF.GQGTLVTVSS (SEQ ID NO： 403) •67- 163920.doc 201245225 BMS3h-56-256 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPQGTRTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFLFQEWGQGTLVTVSS (SEQ ID NO： 404) BMS3h-56-257 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSArNPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPTRFEDWGQGTLVTVSS (SEQ ID NO: 405) BMS3h-56-258 EVQLLESGG6LVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTV5S (SEQ ID NO： 406) BMS3h-56-259 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMN5LRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO； 407) BMS3h-56-260 EVQLLES6GGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAPGKGLEHVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPTFFKDWGQ6TLVTVSS (SEQ ID NO： 408) BMS3h-56-261 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPQGTRTYYADSVK6RFTI5R0NSKNTL YLQMNSLRAEDTAVYYCAKLPFFFQEW6QGTLVTVSS (SEQ ID NO： 409) BMS3h-56-262 EVQLLESGGGLVQP66SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPQLFHDRGQ6TLVTVSS (SEQ ID NO： 410) BMS3h-56-263 EVQLLESG6GLVQPGGSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAE0TAVYYCAKLPQLFEDW6QGTLVTVSS (SEQ ID NO： 411) BMS3h-56-264 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPF6FSEW6QGTLVTVSS (SEQ ID NO： 412) BMS3h-56-265 EVQLLES6GGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDMSKNTL YLQMNSLRAEDTAVYYCAKLPQLFQDWGQGTLVTVSS (SEQ ID NO: 413) BMSBh-56-266 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFFFHEW6Q6TLVTVSS (SEQ ID NO： 414) BMS3h-56-267 EVQLLES6GGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMN5LRAEDTAVYYCAKLPHYFKDWGQGTLVTVSS (SEQ ID NO： 415) BMS3h-56-268 EVQLLESGGGLVQSGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQ6TRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFEEWGQGTLVTVSS (SEQ ID NO： 416) 68-
163920.doc 201245225 BMS3h-56-269 EVQLLESGGGLVQPGGSLRLSCAASG-TFRDYEMWnfVRQAPGKGLERVSAINPQGTRTYYAOSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFRFSDRGQGTLVTVSS (SEQ ID NO: 417) BMSBh-56-270 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPTLFQDI^IGQGTLVTVSS (SEQ ID NO: 418) BMSBh-56-271 EVQLLESGG6LVQPGGSLRLSCAASGI=TFRDYEMWWVRQAPGK6LERVSAINPQGTRTVYADSVKGRFTISR0NSKNTL YLQMNSLRAEDTAVYYCAKLPFYFSB^IGQGTLVTVSN (SEQ ID NO： 419) BMS3h-56-272 EVQLLESGG6LVQPGGSLRLSCAASGI:TFRDYEMWWVRQAP6K6LERVSAINPQ6TRTYYADSVKGRFTISRDNSKNTL YL(^IMSLRAEDTAVYVCAKLPFWF<2日>IGQ6TLVTVSS (SEQ ID NO: 420) BMSBh-56-273 EVQLLESGGGLVQPG6SLRLSCAASGI:TFRDYEMWWVRQAP6K6LERVSAINPWGSLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFQEW6QOTLVTVSS (SEQ ID NO: 421) BMS3h-56-274
EVQLLESGG6LVQPG6SLRLSCAASGI:TFRDYEMWWVRQAP6K6LERVSAINPWGSLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPMFFEDliiGQGTLVTVSN (SEQ ID NO： 422) BMS3h-56-275 EVQLLESGGGLVQPGGSLRLSCAASGI:TFRDYEMWWVRQAPGKGLERVSAINPW6SLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFHEl»IGQGTLVTVSS (SEQ 10 NO： 423) BMS3h-56-276 EVQLLESG6GLVQP6GSLRLSCAAS6I:TFRDYEMWWVRQAP6KGLERVSAINPWGSLTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFFFQEW6QGTLVTVSS (SEQ ID NO： 424) BMS3h-56-277 EVQLLESGGGLVQPGGSLRLSCAASGI:TFRDYEMWWVRQAP6KGLERVSAINPWGSLTYYADSVK6RFTISRDMSKNTL YLQMNSLRAEDTAVYYCAKLPFFFHEViGQGTLVTVSS (SEQ ID NO： 425) BMSBh-56-278 EVQLLESGG6LVQP6GSLRLSCAASGI:TFRDYEMWWVRQAP6KGLERVSAINPWGGFTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFQEW6QGTLVTVSS (SEQ ID NO： 426) BMS3h-56-279 EVQLLESGGGI,VQPGG5LRLSCAAS6i：TFRDYEMWWVRQAP6K6LERVSAINPW66FTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPMFFEDliGQGTLVTVSN (SEQ ID W： 427) BMS3h-56-280 EVQLLESGGGLVQPGGSLRLSCAAS6ITFRDYEMWWVRQAP6K6LERVSAINPWGGFTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEOTAVYYCAKLPFYFHEWGQGTLVTVSS (SEQ ID NO: 428) 69- 163920.doc 201245225 BMS3h-56-281 EVQLLESGGGLVQP6GSLRLSCAASGFTFRDYEMWWVRQAP6KGLERVSAINPWG6FTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFFFQEWGQ6TLVTVSS (SEQ ID NO: 429) BMS3h-56-282 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGK6LERVSAINPWGGFTYYAD5VKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFFFHEWGQGTLVTVSS (SEQ ID NO: 430) BMS3H-56-283 EVQLLES6G6LVQP66SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPW6GLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFQEWGQ6TLVTVSS (SEQ ID NO： 431) BMS3H-56-284 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMUMVRQAP6KGLERVSAINPWGGLTYyADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPMFFEDWGQ6TLVTVSN (SEQ ID NO： 432) BMS3h-56-285 EVQLLES6GGLVQP6GSLRLSCAAS6FTFRDYEMWWVRQAPGKGLERVSAINPWG6LTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSS (SEQ ID NO： 433) BMS3h-56-286 EVQLLESGGGLVQPG6SLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPWG6LTYYADSVKGRFTISRDNSKNTI YLQMNSLRAEDTAVYYCAKLPFFFQEWGQ6TLVTVSS (SEQ ID NO: 4B4) BMS3h-56-287 EVQLLESGGGLVQPGeSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPWGGLTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKLPFFFHEWGQGTLVTVSS (SEQ ID NO： 435) BM53h-56-288 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKLPMFFEDW6QGTLVTVSS (SEQ ID NO： 436) BMS3h-106-l EVQLLETGGGLVQPGGSLRLSCAASGFTFSTYHMQWVRRAPGKGLEWVSMIDADGL6TYYADPVKGRFTISRDNSKNTL YLQMNSLRAKDTAVYYCARPGPQFGQFDYLGQGTLVTVSS (SEQ ID NO: 437) BMS3h-106-2 EVQLFESGGGLVQTG6SLRLSCMSGFTFSTYHMQWVRQAPGKGLEWVSMIDADGLGKYYADPVK6RFTISRDNSKNTL YLQMNSLRAEDTAWYCVKPGPQFGQYDYWGQ6TLVTVSS (SEQ ID NO: 438) BMS3h-107-l EVQLLESGGGLVQP6GSLRLSCSASGFTFS6YDMQWVRQAPGKGLEWVSTISASGVYTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKYPNRFALNSFDYRGR6TLVTVSS (SEQ ID NO: 439) BMSBh-107-2 EVQLLES6GGLVQPGGSLRLSCAASGFTFSGYDMQWVRQAPGRGLEWVSTISAS6VYTYYTDSVKGRFTTSRDNSKNTL YLQMNSLRAEDTAVYYCTKYPNRFARNNFDYWGQGTLVTVSS (SEQ ID NO： 440) BMS3h-131-l DILMTQSPSSLSASVGDRVTITCRANSSILWALAWYQQKPGEAPKLLIESSSGLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCVQNAVWPGTFSQGTKVEIKR (SEQ ID NO： 441) 70- 163920.doc 201245225 BMS3h-131-2 DIQMTQSPSSLSASVGDRVTITCRADSSILWALAWYQQKPGKAPKLLIESSSGLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCVQNAVWP6TF6Q6TKVE：[KR (SEQ ID NO: 442)
BMSBh-131-B DIQMTVSPSSLSASVGDRVTITCRAD：；SILWALAWYQQKPGKAPKLLIESSSGLQSGVPSRFSGS6SGTDFTLTISSLQ PEDFATyYCVQNAVWP6TFGQGTKVE：tKR (SEQ ID NO: 443) BMS3h-131-4 DIQMTQSPSSLSASVGDRVTITCRAN2iSILWAlAWYQQKPGKAPKLLIESSSGLQSGVPSRFS6SGSGTDFTLTISSLQ PEDFATYYCVQNAVWP6TF0QGTKVE：EKR (SEQ ID NO: 444) BMS3h-131-5 DIQMTQSPSSLSASV6DRVnTCRAN*；SILWALAWYQQKPGKAPKLLIESSTGLQSGVPSRFSGSGS6TDFTLTISSLQ PEDFATYYCVQMAVWPGTFGQGTKVE：:KR (SEQ ID NO： 445) BMS3H-131-6 DIQMTVSPSSLSASVGDRVTITCRANiiSILWALAWYQQKPGKAPKLLIESSSGLQSGVPSRFSGSGSGTOFTLTISSLQ PEDFATYYCVQNAVWPGTFGQGTKVEj：KR (SEQ ID W： 446) BMSBh-131-7
DIQMTQSPSSLSASVGDRVriTCRADfiSILWAUWYQQKPGKAPKLLIESSSGLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCVQNAVWPGTFDQGTKV£j：KR (SEQ ID NO： 447) BMS3h-131-8 DIQMTQSPSSLSASVGDRVTITCRANiiSILVIAUWYQQKPGKAPELLIESSSGLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCVQNAVWP6TFGQGTKVE]：KR (SEQ ID NO: 448) BMSBh-131-9 DIQMTQSPSSLSASVGORVTITCRANfiSILWALAWyQQKPGKAPKLLIESSSGLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCVQNAVWP6TFGQ6TKVEMKR (SEQ ID NO： 449) BMS3h-131-10 DIQMTQSPSSLSASV6DRVTITCRAN5iSILWAUWYQQKPGKAPKLLIESSSGLQS6VPSRFS6SGS6TDFTLTISSLQ PEDFATYYCVQNAVWPGTFG»5TKVE]：KR (SEQ ID NO： 450) BMS3h-131-ll DIQMTQSPSSLSASV6DRVTITCRANfiSILWALAWYQQKP6KAPKLLIESSSGLQS6IPSRFSGSGS6TDFTLTISSLQ PEDFATYYCVQNAVWPGTF6QGTKVE]：KR (SEQ ID NO： 451) BMSBh-131-12 DIQMTQSPSSLSASV6DRVTITCRANi；SILWALAWYQQKPGKAPKLLIESSSGLQSGVPSRFSGS6SGTDFTLTISSLQ PEDFATYYCVQNAVWPGTFGQGTKVE3：KR (SEQ ID NO： 452) BMSBh-131-13 DILLTQSPSSLSASV6DRVTITCRAWi；SILWAUWYQQKPGKAPKLLIESSSGLQS6VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCVQNAVWPGTFGQ6TKVE]；KR (SEQ ID NO： 453) -71 - 163920.doc 201245225 BMS3h-131-14 DIQMTQSPSSLSASV6DRVTITCRANSSILWALAWYQQKPGKAPKLLIESSSGLQSGVPSRFS6S6T6TDFTLTISGLQ PEDFATYYCVQNAVWPGTFOQGTKVEIKR (SEQ ID NO： 454) BMS3h-131-15 DIQMTQSPSSLSASVGDRVTIPCRANSSILWALAWYQQKP6KAPKLLIESSSGLQS6VPSRFSGSASGTDFTLTISSLQ PEDFATYYCVQNAVWPGTFGQGTKVEIKR (SEQ ID NO: 455) BMS3H-193-1 DIQMAQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGS6TDFTLTISSLQ PEDFATYYCHQYASPPLTLGQGTKVEIKR (SEQ ID NO: 456) BMS3h-193-2 DIQMrTQSPSSLSASVGDSVTITCRASQTIERRLNWYQQKPGEAPKLLIYLASRLQSGVPSRFS6S6SGTDFTLTISSLQ PEDFATYYCHQYASPPLTF6QGTNVEIKR (SEQ ID NO; 457) BMS3h-193-3 DIQMTQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGS6S6TDFTLTISSLQ PEDFAAYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 458) BMS3h-193-4 DIQMTQSPSSLSASVGDRVTITCRASRTIERRLNWYQQKPGKAPKLLIYLASRLQS6VPSRFS6S<3$CTDFTLTISSUi PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 459) BMS3h-193-5 DIQMTQSPSSLSASVGERVnTCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISNLQ PEDSATyYCHQYASPPLTLGQGTKVEIKR (SEQ ID NO： 460) BMS3h-193-6 DIQMTQSPSSLSASVGDRVnTCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYASPPLTLGQGTKVEIKR (SEQ ID NO： 461) BMS3h-193-7 DIQITQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGKDPKLLIYLASRLQSGVPSRFS6SGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 462) BM53h-193-8 DIQMTQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGEAPKLLIYUSRLQSGVPSRFSGS6SGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKW (SEQ ID NO: 463) BMS3h-193-9 DIQLTQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQS6VP5RFS6S6S6TEFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 464) BMS3h-193-10 DIQMSQSPSTLSASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLMF6QGTKVEIKR (SEQ ID NO: 465) BMS3h-193-ll DIQMTQ5PSSLSASVGDRVTITCRASQTIERRLNWYQQKP6KDPKLLIYLASRLQS6VPSRFSGSGS6TDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 466) 72·
I63920.doc 201245225 BMS3h-193-12 DIQMTQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO: 467) BMS3h-19B-l3 DIQMTQSPSSLFASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGS6S6TDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO； 468) BMS3H-193-14 DIQMTQYPSSLSASVGDRVTITCRASQSIERRLNWYQQKPGEAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID 469) BMS3h-193-15 DIQMTQSPSSLSASV®RVTITCRASRTIERRLNWYQQKPGKAPKLLIYLASRLQS6VPSRFS6SGS6TDFTLTISSLQ PEDFATYYCHPYESPPLTFGQ6TKVEIKR (SEQ ID NO： 47β) BMS3h-193-16 DIQMTQSPSSLSASVGDRVTITCRASQAIERRLNWY®JKPGKAPKLLIYLASRLQS6VPSRFSGS6S6TDFTLTISSLQ PEDFATYYCHQYASPPLTLGQ6TKVEIKR <SEQ ID NO: 471) BMS3h-193-17
NIQMTQSPSSLSASVGDRVTITCRASQAIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO: 472) BMS3h-193-18 DIQMTQSPSSLSASVGDRVTITCRASQTIGRRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGSDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 473) BMS3h-193-19 DIQMTQSPSSLSASV6DRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTEFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 474) BMS3h-193-20 DIQMrQTPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGEAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTF6Q6TKVKIKR (SEQ ID NO: 475) BMS3H-193-21 DK^TQSPSSLSASVGOSVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTOFTLTISSLQ PEDFATYYCHQYESPPLTFGQC5TKVEIKR (SEQ ID NO： 476) BMS3h-193-22 HIQMTQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 477) BMS3h-193-23 DVQMTQSPSSLSASVG0RVTITCRASQTIERRLNWYQQKP6EAPKLLIYLTSRLQSGVPSRFS6S6SGTDFTLTISSLQ PEDFATYYCHQYASPPLTFGQ6TKVEIKR (SEQ ID NO： 478) 73- 163920.doc 201245225 BMSBh-193-24 DIQMTQSPSSLSASVGDRVTITCRASQTIERRLNWYQQKPGKAPKLLIYLASRLQS6VPSRFS6S6SGT0FTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKWIKR (SEQ ID NO： 479) BMS3h-193-25 DIQMTQSPSSLSASV6DRVTITCRASQTIERRINWYQQKPGKAPRLLIYLATRLQSGVPSRFS6SGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 480) BMSBh-193-26 DIQMTQSPSSLSASVGDRVTITCRASQPIERRLNWYQQKP6KAPKLLIYLASRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 481) BMS3h-193-27 DIQMTQSPSSLSASV6DRVTITCRASQTIGRRLNWYQQKPGKAPKLLIYLASRLQSGVPSRFS6SGS6TDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 482) BM53h-193-28 DIQMTQSPSSLSASVGDRVTITCRASQSIERRLNWYQQKP6KAPKLLIYLASRLQS6VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIIR (SEQ ID NO： 483) BMS3h-193-29 DIQMTQSPS$LSASVGDRVTITCRASQTIERRLNWYQQKP6KAPKLLIYLATRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 484) BMS3h-193-30 DIQMTQSPSSLSASV6DRVTITCRASQSIERRLNWYQQKP6KAPKLLIYLASRLQS6VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO: 485) BMSBh-193-2501 DIQMTQSPSSLSASV6DRVTITCRASQTIERRLNWYQQKPGKAPRLLIYLATRLQSGVPSRPSGS6S6TDFTLTISSLQ PEDFATYYCHQFEHPPLTFGQGTKVEIKR (SEQ ID NO： 486) BMS3h-193-2502 DIQMTQSPSSLSASVGDRVTITCRASFPIDRRLNWy〇QKP6KAPRLLIYLATRLQSGVPSRFSGS6SGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 487) BMS3h-193-2503 DIQMTQSPSSLSASVGDRVTITCRAS5TI6RRLNWYQQKPGKAPRLLIYLATRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 488) BMS3h-193-2504 DIQMTQSPSSLSASVGDRVTITCRASSQIGRRLNWYQQKPGKAPRLLIYLATRLQSGVPSRFSGSGS6TDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO: 489) BMS3h-193-2505 DIQMTQSPSSLSASVGDRVTITCRASERIGRRLNWYQQKP6KAPRLLIYLATRLQ5GVPSRFS6SGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 490) BMS3h-193-2506 DIQMTQSPSSLSASVGDRVTITCRASQQI6RRLNWYQQKPGKAPRLLIYLATRLQSGVPSRFS6SGS6TDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 491) 74-
163920.doc 201245225 BMS3h-193-2507 DIQMTQSPSSLSASV6DRVTITCRASQPIARRLNWYQQKPGKAPRLLIYLATRLQSGVPSRFS6S6SGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQ6TKVEKR (SEQ ID NO： 492) BMS3h-19B-2508 DIQMTQSPSSLSASVGDRVTITCRASGMI6RRLNWYQQKPGKAPRLLIYLATRLQSGVPSRFS6S6S6TDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 493) BMS3h-193-2509 DIQMTQSPSSLSASV6DRVTITCRASR.MIDRRLNWYQQKPGKAPRLIIYLATRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 494) BMS3h-193-2510 DIQMTQSPSSLSASVGDRVTITCRASQ5IGRRLNWYQQKPGKAPRLLIYLATRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 495) BMS3H-193-2511 DH^ITQSPSSLSASVGDRVTITCRASQ'JIGTRLNWyQQKPGKAPRLLIYLATRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO: 496) BMS3h-193-2512
DIQMTQSPSSLSASVGDRVTITCRASEVI6RRINWYQQKPGKAPRLLIYLATRLQSC5VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO: 497>
BMS3h-193-251B DIQMTQSPSSLSASVGDRVTITCRASEAIGRRLNWYQQKP6KAPRLLIYLATRLQS6VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 498) BMS3h-193-2514 DIQMTQSPSSLSASV6DRVTITCRAST5IARRLNWYQQKPGKAPRLLIYLATRLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEKR (SEQ ID NO: 499) BMSBh-193-25a5 DIQMTQSPSSLSASVGDRVTITCRASL)JIGRRLNWYQQKPGKAPRLLIYLATRLQS6VPSRFS6SGS6TDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 500) BMS3h-193-2516 DIQMTQSPSSLSASVGORVTITCRASQnERRLNWYQQKPGKAPRLLIYLSSKLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCHQYESPPLTFGQGTKVEIKR (SEQ ID NO： 5Θ1) BMS3H-198-1 EVQLLESGGGLVQPGGSLRLSCAASGSriAGYEMWWVRQAPGKGLERVSAISGSGGSTYYADSVKGRFTISRDOSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYWGQGTLVTVSS (SEQ ID NO: 502) BMS3h-198-2 EVQPLESG66LVQP6GSLRLSCAASGFTFA6YEMWWVRQAPGKGLERISAIS6S6GSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYWGQ6TLVTVSS (SEQ ID NO： 503) 75- 163920.doc 201245225 BMS3h-198-3 EVQLLESGG6SVQPG6SLRLSCAAT6STFAGYEMWWVRQAPGKGLERVSAISGSGG5TYYA0SVK6RFTI5RDDSKNTL YLQMNSLRAEDTAVYYCARDPYSYDVWGQ6TLVSVSS (SEQ ID NO: 504) BMS3h-198-4 EVQLLESG6GLVQPG6SLRLSCAA5GLTFA6YEMWWVRQAPGK6LERVSAIS6S6G5TYVADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYHCARDPYSFDYW6QGTLVTVSS (SEQ ID NO: 505) BMS3h-198-5 EVQLLES6GGLVQPGGSLRLSCAASGFTFAGYEMWWVRQAPGKGLERVSAISGS66STYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAWHCAKEPYSYDVWGQGTLVTVSS (SEQ ID NO: 506) BMS3h-198-6 EVQLLESGGGLVQPGGSLRLSCAASGSTFAGYEMWWVRQAP6KGLERVSAISGS66STYYADSVKGRFTISRDDSKNTL YLQMNSLRPEDTAVYYCVKDPYSFDVWGQ6TLVTVSS (SEQ ID NO: 507) BMS3h-198-7 EVQLLESGGGLVQPGGSLRLSCAAS6STIAGYEMWWVRQAP6KGLERVSAISGSGGSTYYA0SVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYWGQGTPVTVSS (SEQ ID NO： 508) BMSBh-198-8 EVQLMES6GGLVQP6GSLRLSCAAS6STFAGYEMWWYRQAPGKGLERVSAISGS6R5TYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVWCAKDPYSFDYWGQ6TLVTVSS (SEQ ID NO: 509) BMS3h-198-9 EVQLLESGGGLVQPGGSLRLSCAAS6FTFAGYEMWWVRQAP6K6LERVSAISGSGGSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKEPYSFDYWGQ6TLVTVSS (SEQ ID NO： 510) BMS3h-198-10 EVQLLESGGGLVQP6GSLRLSCAASGSTIA6YEMWWVRQAPGKGLERVSAIS6SGGSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDYWGQ6TLVTVSS (SEQ ID NO: 511) BMS3H-198-11 EVQLLESGG6LVQPG6SLRLSCAASGFTFAGYEMWWVRQAPGK6LERVSAIS6SGGSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYWGQGTLVSVSS (SEQ ID NO： 512) BMS3h-198-12 EVQLLESGGGLVQPG6SLRLSCAASGFTIAGYEMWWVRQAPGKGLERVSAIS6SGGSTYYADSVK6RFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDYWGQ6TLVTVSS (SEQ ID NO： 513) BMS3h-198-13 EVQLLESG6GLVQPGGSLRLSCAASGFTFAGYEMWWVRQAPGK6LERVSAISGS(3GSTYYADSVKGRFTITRDDSKNTL YLQMNSLRAEDTAVYYCAKEPYSFDYWGQ6TLVTV5S (SEQ ID NO： 514) BMS3h-198-14 EVQLLESGGGLVQPGGSLRLSCAASGFTFAGYEMWWFRQAPGKGLERVSAIS6SG6STYYADSVKGRFTISRDDTKNTL YLQMNSLRAEDTAVYYCAKDPYSFDYWRQGTLVTVSS (SEQ ID NO： 515) BM53h-198-15 EVQLLESGGGLVQPGGSLRLSCAASGSTFAGYEVWWVRQAPGKGLERVSAISGSGGSTYYADSVK6RFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYWGQGTLVTVSS (SEQ ID NO： 516) 76·
163920.doc 201245225 BMS3h-198-16 EVQLLESGGGLVQPGGSLRLSCAAS6i；TFAGYEMWWVRQAPGKGLERISAISGSG6STYYADSVKGRFTISRDDSKNTL YLKMNSLRAEDTAVYYCAKDPYSFDYliGQGTLVTVSS (SEQ ID NO： 517) BMS3h-198-17 EVQLLESGGGLVQP6GSLRLSCAAS6F:TFAGYEMWWVRQAP6K6LERVSAIS6SG6STYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYlrlGQOTLVTVSS (SEQ ID NO： 518) BMS3h-198-18 EVQLLESGG6LVQP66SLRLSCAAS61.TFAGYEMWWVRRAPGKGLERVAAISGSGGSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYWGQGTLVTVSS (SEQ ID NO： 519) BMSBh-198-19 EVQLLESGGGLVQPGG5LRLSCAAS6FTFAGYELWWVRQAP6K6LERVSAIS6S6GSTVYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYF.GQGTLVTVSS (SEQ ID NO： 520) BMS3h-198-20 EVQLLESGG6LVQPG6SLRLSCAAPGFTLAGYEMWWVRQAP6K6LERV5AISGSGGSTYYADSVKGRFTISRDD5KNTL YLQMNSLRAEDTAVYYCAKEPYSFDYVilGQGTLVTVSS (SEQ ID NO： 521) BMSBh-198-21
EVQLLESG66LVQP66SLRLSCAASGLTFAGYEMWWVRRAPGKGLERVSAIS6S6GSTYYADSVKGRFTTSRDDSKNTL YLQMNSLRAEOTAWYCARDPYSFDYUGRGTLVTVSS (SEQ ID NO： 522) BMS3h-198-22 EVQLLES66GLVQPG6SLRLSCAAS6FTFA6YEMWWVRQAPGKGLERVSAISGSGGSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVyYCAKEPYSYDYUGHGTLVTVSS (SEQ ID NO： 523) BMS3h-198-23 EVQPLESG6GLVQPGG5LRL5CAASGFTFAGYEMWWVRQAP6K6LERVSAISGSG6NTYYADSVK6RFTISRDDSKNTL YLQMNSLRAEDTGVYYCARDPYSFDY^GQGTLVTVSS (SEQ ID NO： 524) BMSBh-198-24 EVQLLESGG6LVQPGGSLRLSCAASGFTFA6YEMWWVRQAPGKGLERVSAISG5GGSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKEPYSFDSKGQGTLVTVSS (SEQ ID NO： 525) BMS3h-198-25 EAQLLESGGGLVQPGGSLRLSCMSGLTFAGYEPW/RQAPGKGLERVSAISGSGGSTYYAOSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCARDPYSFDYUGQGTLVTVSS (SEQ ID NO： 526) BMS3h-198-26 EVQLLES6G6LVQPGGSLRLSCAASGSTFAGYEMWWVRQAPGKGLERVSAIS6SGGSTYVADSVKGRFSISRDDSKNTL YLQMNSLRAEDTAVYYCAKEPYSFDHkGQGTLVTVSS (SEQ ID NO： 527) BMS3h-19847 EVQLLE5GG6LVQPGGSLRLSCAASGSTFAGYEMWWVRRAPGKGLERVSAISGSGGSTWADSVKGRFTISRDOSKNTL VLQMNSLRAEDTAVYYCARDPYSFDYW6QGTLVTVSS (SEQ ID NO： 528) 77- 163920.doc 201245225 BMS3h-198-28 EVQLLES6GGLVQP66SLRLSCAASGFTFAGYEMWWFRQAP6KGLERVSAISGSGGSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDNWGQGTLVTVSS (SEQ ID NO： 529) BMS3h-198-29 EVQLLES6G6LVEPG6SLRLSCAASGFTFA6YEMWWVRQAPGKGLERVSAISGSG6STYYADSVK6RFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKEPYSFDHRGQGTLVTVSS (SEQ ID NO: 530) BMS3h-198-30 EVQLLESGGGLVQP6GSLRLSCAASGYTFAGYEMWWVRQAPGKGLERVSAISGSG6STYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKEPVSFDHRGQGTLVTVSS (SEQ ID NO： 531) BMS3h-198-31 EVQLLESGGGLVQPG6SLRLSCAASGFTFAGYEMWWVRQAPGK6LERVSAISGSGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYHCAKEPYSYDYWGQGTLVTVSS (SEQ ID NO： 532) BMSBh-198-B2 EVQLLESG6GLVQPGGSLRLSCAASGFTFA6YEMWWFRQAPGKGLERVSAIS6S6GSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDNW6QGTLVTVSS (SEQ ID NO： 533) BMSBh-198-33 EVQLLES6GGLVQPGGSLRLSCAASGFTFAGYEMWWVRQAP6KGLERVSAISGSGGSTYYADSVK6RFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKEPYSYDYWGQGTLVTVSS (SEQ ID NO： 534) BMS3h-198-34 EVQLLESGGGLVQPGGSLRLSCAAS6FTFAGYEMWWVRQAPGKGLERVSAIS6S66STYYADSVK6RFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDNWGQ6TLVTV5S (SEQ ID NO： 535) BMS3h-198-35 EVQLLESGGGLVQPGGSLRLSCAASGFTFAGYEMWWVRQAPGKGLEWVSAISCSGGSTYYAOSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYHCAKEPYSYDYWGQGTLVTVSS (SEQ ID NO： 536) BMS3h-198-36 EVQLLESG66LVQP66SLRLSCAASGFTFAGYEMWWFRQAP6K6LEWVSAIS6S6GSTYYADSVKGRFTISRDDSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDNWGQGTLVTVSS (SEQ ID NO： 537) BMS3h-198-37 EVQLLESGGGLVQPGGSLRLSCAASGFTFAGYELWWVRQAPGKGLERVSAISGSGGSTYYADSVKGRFnSRDDSKNTL YLQMNSLRAEDTAVYYCAKDPYSFDYRGQGTLVTVSS (SEQ ID NO: 538) BMS3H-198-38 EVQLLES6GGLVQPGGSLRLSCAASGFTFAGYELWWVRQAPGKGLERVSAISGSGGSTYYADSVK6RFTISRDDSKNTL YLQMNSLRAEDTAmCARDPYSFDYWGQGTLVTVSS (SEQ ID NO： 539) BMS3h-202-l EVQLLESGGGLVQPGGSLRLSCAASGFTFPTAEMLWVRKAPGKGLEWVSSISASGGSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPVSWATFDYW6QOTLVTVSS (SEQ ID NO： 54Θ) BMS3h-202-2 EVQLLVSGGGLVQPGGSLRL5CAAS6FTFPTAEMLWVRQAP6KGPEWVSSISAS6GSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPVSWATFDYWGQ6TLVTVSS (SEQ ID NO: 541) 78- 163920.doc 201245225 BMS3h-202-3 EVQLLESG6GLVQPG6SLRLSCAASGFTFPTAEMVWVRKAPGMGLEWVSSISASGGYTYYADSVK6RFTI5RDN5KNML YLQMNSLRAEDTAVYYCAKEPVSYVATFDYWGQGALVTVTS (SEQ ID NO： 5A2) BMSBh-202-4 EVQLLVS6GGLVQPGGSLRLSCAAS(；FTFPTAEMVWVRQAP6KGLEWVSSISASG6STYYADSVKGRFSISRDDSKNTL YLQMNSLRAEDTAVYYCAKEPVSYVATFDYW6HGALVTVSS (SEQ ID NO： 543) BMSBh-202-5 EVQLLESGGGLVQPGGSLRLSCAASGFTFPTAEMLWVRQAPGKGLEWVSSISASGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPVSYVATFDYWGQ6TLVTVSS (SEQ ID NO： 544) BMS3h-202-6 EAQLLESG66LVQPGGSLRLSCAAS(5FTFPTAEMVWVRQAPGK6LEWISSISASGGSTYYADSVKGRFTISRDNSKNTL YLQLNSLRAEDTAVYYCAKEPVSYVATFDYWGRGTLVTVSS (SEQ ID NO： 545) BMS3h-202-7 EVQLLES66GLVQPGGSLRLSCAAS(5FTFPTAEMLWVRQAP6K6LEWVSSISASG6STYYADSVKGRFTISRDNSKSTL YLQMNSLRAEDTAVYYCAKEPVSWATFDYWGPGALVTVSS (SEQ ID NO: 546) BMS3h-202-8
EVQLLESGGGLVQPGGSLRLSCAASCSFTFPTAEMLWVRKAPGKGLEWVSSISASGGSTYYADSVKGRFTISRDNSKNTL FLQMNSLRAEDTAVYYCAKEPVSYVy^TFDYWGQGTLVTVSS (SEQ ID NO: 547) BMS3h-202-9 EVQLLES6GGLVQP6GSLRLSCAAS(iFTFPTAEMLWVRQAP6KGLEWVSSISASGGSTYYADSVK6RFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPVSYVATFDYWGPGALVTV5S (SEQ ID NO： 548) BMS3h-202-10 EVQLLESGGGLVQPGGSLRLSCAASCiFTFPTAEMLWVRQAPGKGLEWVSSISASGGSTYYADSVKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCAKEPVYYV/vTFDYWGQGTLVTVSS (SEQ ID NO： 549) 8MS3h-202-ll EVQLLESGG6LVQPG65LRL5CAAS<iFTFPTAEMLWVRKAPGKGLEWV5SISASGGSTYYADSVK6RFTISRONSKNTL YLQMNSLRAEDAAVYYCAKEPVSYVATFDYWGQGTLVTVSS (SEQ ID NO： 550) BMS3h-217-l NIQMTQSPSSLSASVGDRVTITCRA5iHFIGTLLTWYQHKP6KAPKLLITY6SLLQS6VPSRFSG$GS6TDFTLTISSLQ PEDFATWCGQGVLWPATFGQGTKVIilKR (SEQ ID WO: 551) BMS3H-217-2 DIQMTQSPSSLSASVGDRVTITCRA5；HFIGTLLSWYQQKPRKAPKLLITYGSLLQSGVPSRF$GSGSGTDFTLTISSLH PEDFATYYCGQGVLWPPTF6QGTKVI：IKR (SEQ ID NO： 552) BMS3h-217-3 DIQMTQSPSSLTASVGDRVTITCRA<；HFIGTLLSWYQQKPGKAPKLLVTY6SLLQSGVPSRFSGS6SGTDFTLTISNLQ PEDFATYYCGQGVLWPPTFGQGTKVEiNIR (SEQ ID NO： 553) 79- 163920.doc 201245225 BMS3h-217-4 DIQMTQSPSSLSASVGDRVTITCRASHFIATLLSWYQQKPGKAPKLLITY6SLLQS6VPSRFSG5GSGTDFTLTISSLQ PEDFATYYCGQGVLWPPTFGQGTKVEIKR (SEQ ID NO: 554) BMS3h-217-5 DIQMTQSPSFLSASV6DRVTITCRASHFIATLLSWYQQKPGKAPKLLITyGSLLQSGVPSRFSGSGSGTDFTLTI5SLQ PEDFATYYCGQGVLWPPTFGQGTKVEIKR (SEQ ID NO: 555) BMS3h-217-6 DIQMTQSPSSLSASV6DRVTITCRASHFIGTLLSWYQQKP6KATKLLITYGSLLQSGVPSRFSGS6SGTDFTLTISSLQ PEDFATYYCG^jVLWPPTFGQGTKVEIKR (SEQ ID NO： 556) BMS3h-217-7 ' DIQMTQSPSSLSASVGDRVTITCRASHFIGSLLSWYQHKPGKAPKLLITY6SLLQS6VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO： 557) BMS3h-217-8 DIQMTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQHKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTDFTLTI5SLQ PEDFATYYC6QGVLWPATFGQGTKVEIKR (SEQ ID NO: 558) BMS3h-217-9 DIQMTQSPSSLSASVGDRVTITCRASHFI6TLLSWYQHKPGKAPKLLITYGSMLQSGVPSRF5GSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO： 559) BMS3h-217-10 DIQMTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQHKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTEFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO： 56Θ) BMS3h-217-ll DIQMTQSPSSLTASVGDRVTITCRASHFIGTLLSWYQHKPGKAPKLLITYGSLLQS6VPSRFS6SGSGTEFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO： 561) BMS3h-217-12 NIQMTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQHKP6KAPKLLITY6SLLQS6VPSRFSGS6SGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO： 562) BMSBh-217-13 DIQMTQSPSSLSASVGDRVTINCRASHFI6TLLSWYQHKPGKAPKLLITYGSLLQSGVPSRFSGS6SGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO： 563) BMS3h-217-14 DIQLTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQQKPGKATKUITYGSLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPPTFGQGTKVEIKR (SEQ ID NO： 564) BMS3h-217-15 DIQMTQSPSSLYASVGDRVTITCRVSHFIGTLLSWYQQKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTDFTLSISSLQ PEDFATYYCGQ6VLWPPTFGQ6TKVEIKQ (SEQ ID NO: 565) BMS3h-217-16 DIQMTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQQKPRKAPKLLITYGSLLQSGVPSRF5G5GSGTDFTLTISSLQ PEDFATYYCGQGVLWPPTFGQGTKVEIKR (SEQ ID NO： 566) 80· 163920.doc 201245225 BMS3K-217-17 0IQIIQSPSSLSASVGDRVTITCRASHFIGTLLSWYQQKP6KAPKL.LITYGSLLQS6VPSRFS6SGSGTDFTLTISSLQ PEDFATYYCGQ6VLWPPTFGQ6TKVE3：KR (SEQ ID NO: 567) BM53h-217-18 DIQMTQSPSSLSASVGDRVTITCRASMFIGTLLSWyQLKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTOFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVE3：KR (SEQ ID NO: 568) BMS3h-217-19 DIQMTQSPSSLSASV6DRVTITCRASHFI6TLLSWYQLKPGKAPKLLITYGSWLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEMKR (SEQ ID NO: 569) BMS3h-217-20 DIQMTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQLKP6KAPKLLITYGSLLQRGVPSRFS6SGSGTDFTLTI5SLQ PEDFATYYCGQ6VLWPATFGQGTKVEIKR (SEQ ID NO: 570) BMSBh-217-21 DIQMTQAP5SLSASVGDRVTITCRASHFI6TLLSWYQLKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEMKR (SEQ ID NO： 571) BMS3h-217-22
DIQMTQSPSSLSASVGDRVTITCRASHFIGSLLSWYQQKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTDFALTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO: 572)
BMS3h-217-2B DIQMTQSPSSLSASV6DRVTITCRASHFI6SLLSWYQVKPGKAPKLLITYGSLLQSGVPSRFS6SGSGTDFTLTISSLQ PEDFATYYC6QGVLWPATFGQGTTVEIKR (SEQ ID NO: 573) BMS3h-217-24 DILMTQSPSSLSASV6DRVTITCRASHFI6SLLSWYQQKPGKAPKLLITYGSLLQSGVPSRFS6SGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO: 574) BMS3h-217-25 DIQMTQSPSSLSASVGDRVTITCRASHFIGTLVSWYQQKPGKAPKLLITY6SLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYC6QGVLWPATVGQGTKVEIKR (SEQ ID NO: 575) BMS3h-217-26 DIQMTQSPSSLSASVGDRVTITCRAShFIGTLVSWYQQKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVENKR (SEQ ID NO： 576) BMS3h-217-27 DIKMTQSPSSLSASV6DRVTITCRASh：FIGTLVSWYQQKP6KAPKLLITYGSMLQS6VPSRFS6SGS6TDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO: 577) BMS3h-217-28 DIQMTQSPSSLSASVGDRVTITCQAShFIGTLVSWYQQKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO： 578) 81· 163920.doc 201245225 BMSBh-217-29 DIQMTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQQKPGKAPKLLITYGSWLQSGVPSRFSGSG5GTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO: 579) BMS3h-217-30 DIQMTQSPSSLSASV6DRVTITCRASHFIGTLLSWYQLKPGKAPKLLITYGSWLQSGVPSRFSGS6SGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO: 580) BMSBh-217-31 DIQMTQSPSSLSASVGDRVTITCRASHFIGTLLSWYQQKP6KAPKLLITYGSLLQSGVPSRFSGSGFGTDFTLTISSLQ PEDFATYYCGQEVLWPATFGQ6TKVEIKR (SEQ ID NO： 581) BMS3h-217-32 DIQMTQSPSSLSASVGDRVSITCRASHFIGTLLSWYQQKPGKAPKLLITyGSLLQSGVPSRFSGSGFGTDFTLTISSLQ PEDLATYYC6QEVLWPATFGQ6TKVEIKR (SEQ ID NO： 582) BMS3h-217-33 DIQMTQSPSSLSASVGDRVTITCQASHFIGTLLSWYQQKPGKAPKLLITYGSLLQS6VP5RFSGSGFGTDFTLTISSLQ PEDFATYYCGQEVLWPATFGQ6TKVEIKR (SEQ ID NO: 583) BMS3h-217-34 DIQMTQSPSSLSASVGDRVTITCRASHFI6TLLSWYQQKPGKAPKLLITYGSLLQSGVPSRFSGS6FGTEFTLTIGSLQ PEDFATYYCGQGVLWPATFGQGTKVEIKR (SEQ ID NO: 584) BMS3h-217-35 DIQMTQSPSSLSASVGDRVTITCRASHFI6TLLSWYQQKPGKATKLLITYGSLLQSGVPSRFS6SGSGTDFTLTISSLQ PEDFATYYCGQGVLWPPTFGQ6TKVEIKR (SEQ ID NO： 585) BMS3h-217-2301 DIQMTQSPSSLSASVGDRVTITCRASHFIASLLSWYQVKP6KAPKLLITYGSLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQ6VLWPATFGQGTTVEIKR (SEQ ID NO: 586) BMS3h-217-2302 DIQMTQSP55LSASV6DRVTITCRASHFIAQLLSWYQVKPGKAPKLLITYGSLLQS6VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATF6Q6TTVEIKR (SEQ ID NO: 587) BMS3h-217-2303 DIQMTQSPSSLSASV6DRVTITCRASHFIAQLLSWYQVKPGKAPKLLITY6SLLQS6VPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVEIRR (SEQ ID NO： 588) BMS3h-217-2B04 DIQMTQSPSSLSASVGDRVTITCRASHYIASLLSWYQVKPGKAPKLLITYGSLLQSOAPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQ6VLWPATFGQGTTVEIKR (SEQ ID NO: 589> BMS3h-217-2B05 OIQMTQSPSSLSASVGDRVTITCRASHFIGSLLSWYQVKPGKAPKLLITWASYLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQ6VLWPATFGQGTTVEIKR (SEQ ID NO： 590) BMS3h-217-2306 DIQMTQSPSSL5ASVGDRVTITCRA5HFI6SLLSWYQVKP6KAPKLLITWTSYLQS6VPSRFS6SGSGTDFTLTISSLQ PEDFATYYC6QGVLWPATFGQGTTVEIKR (SEQ ID NO： 591) 82· 163920.doc 201245225 BMS3K-217-2307 DIQMTQSPSSLSASVGDRVTITCRASHFI6SLLSWYQVKPGKAPKLLITWSSYLQS6VPSRFS6SGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATF6QGTTVIEIKR (SEQ ID NO： 592) BMS3h-217-2308 DIQMTQSPSSLSASVGDRVTITCRA：：HFIGSLLSWYQVKPGKAPKLLITW6SWLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVIilKR (SEQ ID NO： 593) BMS3h-217-2309 DIQMTQSPSSLSASVGDRVTITCRAfiHFIGSLLSWYQVKPGKAPKLLITWASWLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVIilKR (SEQ ID NO： 594) BMS3h-217-2310 DIQMTQSPSSLSASVGDRVTITCRAiiHFIGSLLSWYQVKPGKAPKLLITWSSWLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVIilKR (SEQ ID NO: 595) BMS3H-217-2311 DIQMTQSPSSLSASVGDRVTITCRAS；HWIAQLLSWYQVKPGKAPKLLITYGSLLQSGVPSRFSGSGS6TDFTLTISSLQ PEDFATYYCGQGVLWPATFGQ6TTVE!IKR (SEQ ID NO： 596) BMS3h-217-2B12
DIQMTQSPSSLSASVGDRVTITCRASHFIGSLLRIaIYQVKPGKAPKLLITYGSLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVEIKR (SEQ ID NO： 597) BMS3h-217-2B13 DIQMTQSPSSLSASVGDRVTITCRASHRIAQLLSWYQVKPGKAPKLLITY6SLLQS6VPSRFS6SGS6TDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVEIKR (SEQ ID NO： 598) BMS3h-217-2B14 DIQMTQSPSSLSASVGDRVTITCRASHYIASLLSWYQVKPGKAPKLLITYGSLLQSGVP5RFSGS<3SGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVEIKR (SEQ 10 NO： 599) BMS3h-217-2315 DIQMTQSPSSLSASVGDRVTITCRASHFI6SLLSWYQVKPGKAPKLLIRFGSLLQSGVPSRFSGS6S6TDFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVEIKR (SEQ ID NO： 600) BMS3H-217-2316 DIQMTQSPSSLSASVGDRVriTCRASHFIGSLLSWYQVKPGKAPKLLITYKSYLQSGVPSRFSGSGSGTOFTLTISSLQ PEDFATYYCGQGVLWPATFGQGTTVEIKR (SEQ ID NO： 601) BMS3h-217-2317 DIQMTQSPSSLSASV6DRVTITCRASHFIGSLLSWYQVKP6KAPKLLITWGSYLQS6VPSRFS6S6SGTDFTLTISSLQ PEDFATYYCQ3GVLWPATF6Q6TTVEIKR (SEQ ID NO： 6Θ2) BMS3h-217-2318 DIQMTQSPSSLSASVGDRVTITCRASHFIWGPLSWYQVKP6KAPKLLITYGSLLQSGVPSRFSG5GSGT0FTLTISSLQ PEDSATYYCGQ6VLWPATFGQGTTVEIKR (SEQ ID NO: 6Θ3) 83- 163920.doc 201245225 BMS3h-217-2319 DIQMTQSPSSLSASVGDRVTITCRASHWIATLLSWYQVKPGKAPKLLltYGSLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQ6VLWPATFGQ6TTVEIKR (SEQ ID NO: 604) BMS3h-217-2320 DIQMTQSPSSLSASVGDRVTITCRASHFIWGPLSWYQVKPGKAPKLLITY6SLLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYC6QGVLWPATFGQ6TTVEIKR (SEQ ID NO： 605) BMSBh-217-2321 DIQMTQSPSSLSASVGDRVTITCRASHFIGSLLNWYQVKPGKAPKLLITYGSLLQSGVPSRFS6S6SGTDFTLTISSLQ PEDFATYYCGQ6VLWPATFGQGTTVEIKR (SEQ ID NO： 606) BMS3h-217-2322 GIQMTQSPSSLSASVGDRVTnCRASHFIGSLLSWYQVKPGKAPKLLITYGSWLQSGVPSRFSGSGSGTDFTLTISSLQ PEDFATYYCGQGVLWPATFGQ6TTVEIKR (SEQ ID NO: 607) 表4 編碼人類抗CD40可變域之核苷酸序列 BMS3H-56-201 GAG6TGCAGCTGTTGGAG 了 CCGGGGGAGGOTGGTACAGCCrGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGCGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC 6CAGGGTAC6C6TACATACTAC6CA6ACTCC6TGAAG6GCC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG 了 ATCTC5CAAATGAACAGCCTGCOTGCCGAG6ACACCGCGGTATAHACTOTGCGAAACTTCCGTnTACTTTCAGGA6T 6GGGTCAGGGAACCCTGGTCACCGTCTC6A6C (SEQ ID NO： 608) BMS3h-56-258 GAGGTGCA6CT6TTG6AGTCT666G6A6GCTTGGTACAGCCT6GG6G6TCCCT6C6TCTCTCCTGT6CA6CCTCC6GAT TCACCTTTCGG6ATTATCAGATGTGGT6GGTCCGCCAG6CTCCAGG6AAGGGTCTA6A6C6G6TCTCAGCTATTAATCC GCAGGGTACGCGTACATACTAC6CA6ACTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTCTGCGAAACnCCGTTTTACTTTCACGAGT GGGGTCAGGGAACCCTGGTCACC6TCTC6AGC (SEQ ID NO： 609) BMS3h-37 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCHGGTACAGCC 了 G6GGGGTCCCTCC6TCTCTCCTCTGCAGCCTCCG6AT TCACCTTTGAGTGCTATGAGATGCAGTGGGTCCGCCAOGCTCCAGGGAAGGCTCTAGAGTGGGTCTCAGCGAmCTGG T6ATGGTTATCGTACATACTACGCA6ACTCCGTGAAAGGCCG6TTCACCATCTCCC6C6ACAATTCCMGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTCTGCGAAAGAGCrTGGGTATTrTGACTACT GGGGTCAGGGAACCCTGGTCACC6TCTC6AGC (SEQ ID NO: 610) BMS3h-38 (5AGGTGCAGCT6TTG6AGTCTGG6GGA6GCTTGGTACAGCCT6GGGG6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6A6GAGGAG6AGAT6ATTTGG6TCCGCCAGGCTCCAGGGAA666TCTAGAGTGGGTCTCAGCTATTAGTGG 了 AGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCXGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGAGCCGnTCGTTTTGACTACT 66GGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 611) •84·
163920.doc 201245225 BMS3h-41 GAGGTGCAGCTGTTGGAGTCTGG6GGAGGCTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTACT6AGTATGAGATGATTTGGGTCCGCCAGGCTCCAGGGAAGG6TCTGGAGTGGGTCTCATCTATTTCGGG TAATGGT6CTAATACATACTACGCAGACTCCGTGAAGGGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCT6CAAATGAACAGCCTGCGTGCCSAGGACACCGCGGTATATTACT6TGCGAAAGAGCCGCTTAGGTTTGACTACT GGG6TCAG66AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 612) BMS3h-43 GAGGTGCAGCTGTTGGAGTCTGG66GA5GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTACAGCCTCCGGAT TCACCTTTAATAT6TATGA6ATGTC6TGG6TCCGCCAGGCTCCAGGGAAGGGTCTA6AGT6GGTCTCAGGTATTA6TAG GCGTGGTTTTACTACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGATACC6CGGTATATTACTGTGCGAAAGAGCCGATTACGTATGCTATGA G6TATGCGCGTTTTGACTACTG66GTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 613) BMS3h-56 GAGGTGCAGCTGTTGGAGTCTG6GGGASGCTTGGTACAGCCTGG6GGGTCCCTGCGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTaCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCA6ACTCCGTGAAGGGCCG6TTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCSAGGATACCGCGGTATAHACTCTGCGAAACTTCCGTTTATTnTGACTAa GGGGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 614) BMS3h-106
GA6GTGCAGCTGTTGGAGTCTGGG6GAGGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTTCGACTTATCATATGCAGTGG6TCCGCCAG6CTCCAGG6AAGGGTCTGGAGTGG6TCTCAATGATTGATGC G6ATGGTCTTGGGACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCCGAG6ACACCGCGOTATATTACTGT6CGAAACCGGGTCCSCAGTTTGGTCA6T TTGACTACTGGGGTCAGGGAACCCTGGrCACCGTCTCGAGC (SEQ ID NO： 615) BMS3h-107 GAGGTGCAGCTGTTGGAGTCTGGGGGASGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCTTCCGGAT TCACCTTTTCGGGGTATGATATGCA6TSGGTCCGCCAG6CTCCAGGGAAGGGTCTA6AGTGG6TCTCAACGATTAGT6C GTC6GGT6TTTTTACATACTACGCAGACTCCGTGAAGGGCC6GTTCACCACCTCCCGCGACAATTCCMGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCSAGGACACCGCGGTATATTACTGTGCGAAATATCCTAATCGTTTTGCGCTTA ATMTTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 616) BMSBh-131 GACATCCAGATGACCCAG 丁 CTCCATCCrCCCTCTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAATA 6TTCTATTTTGTGG6CGTTA6CTTG6TACCAGCAGAAACCA6G6AAAGCCCCTAAGCTCCT6ATCGAGAGTTCTTCCGG TTT6CAAAGT6G6GTCCCATCACGTTTCA6T6GCAGTGGATCTGG6ACAGATTTCACTCTCACCATCA6CA6TaGCAA CCTGAAGATmGCTACGTACTACTCTGTTCAGAATGCGGGTTGGCCTGGTACCTTCGGCCAAGGGACCMGGTGGAAA TCAAACGG (SEQ ID NO: 617) BMS3h-193 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAOTC AGACGATTGAGCGTCGTTTAMTTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAA6T6GG6TCCCATCACGTTTCAGTG6CAGTG6ATCT6GGACAGATTTCACTCTCACCATCAGCAGTaGCAA CCTGAAGATTTTGCTACGTACTACTGTCATCAGTATGCGAGTCCACaTTGACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 618) 85- 163920.doc 201245225 BMS3h-198 6A66TGCA6CTGTT66A6TCTG6GGGAG6aTGGTACA6CCTGGGGGGTCCCT6C6TCTCTCCT6T6CA6CCTCCGGAT TCACCTTTGCTG6GTATGA6AT6T6GT666TCC6CCAGGCTCCAGGGAAG6GTCTAGAGCGGGTCTCAGCTATTAOTGG TAGTGGT6GTAGCACATACTACGCAGACTCCGTGAA66GCC66TTCACCATCTCCC6C6ACGATTCCAAGAACACGCTG TATCT6CAAAT6AACA6CCT6C6TGCC6AGGATACCGCGGTATATTACTGTGCGAAAGATCCTTATA6TTTT6ACTACT 66G6TCA6GGAACCCT66TCACCGTCTC6AGC (SEQ ID NO: 619) BMS3h-202 GAGGTGCA6CTGTT6GA6TCTGG6GGA6GCTTGGTACAGCCTGG6GG6TCCCTGCGTCTCTCCT6TGCAGCCTCC6GAT TCACCmCCGACTGCTGA^TGOTGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTTCGGC TAGTG6TG6TTCTACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACAC6CTG TATCT6CAAATGMCAGCCTGC6TGCC6AGGACACCGC6GTATATTACTGTGCGAAAGAGCC66T6A6TTAT6TGGC6A C6TTT6ACTACrGGGGTCAGG6AACCCTG6TCACCGTCTC6AGC (SEQ ID NO: 620) BMS3h-217 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTACTCT6TTATCTTGGTACCA6CAGAAACCAGGGAAA6CCCCTAAGCTCCTGATCACTTAT6GTTCCTT GTTGCAAAGTGG66TCCCATCACGTTTCAGTGGCAGT6GATCTGGGACAGATTTCACTCTCACCATCAGCAGTCT6CAA CCTGAAGATTTT6CTACGTACTACTGTGGTCAGGG6GTGCT6TGGCCTGCGACGTTCGGCCAA66GACCAAGGT66AAA TCAAACG6 (SEQ ID NO： 621) BMS3H-1 6AGGT6CAGCTGTTGGA6TCTGGGGGAGGCTTGGTACAGCCTG6GGGGTCCCT6C6TCTCTCCT6T6CAGCCTCCG6AT TCACCTTTCCGAAGAATGAGATGACGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCGATTGAGTC GGATG6TCAGGCTACATACTAC6CA6ACTCC6TGAAGG6CCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCTGA6GACACCGCGGTATATTACTGTGCGAAAAATCGGATTCCTGATCTTGT6T TTGACTACTGGGCTCAG6GAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 622) BMS3h-2 GAG6TGCA6CTGTTGGAGTCTGGGGGAGGCTT66TACA6CCTG666GGTCCCT6C6TCTCTCCT6T6CAGCCTCCG6AT TCACCnTGATGCTGGGGCTATGACGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTGATM 6GAGGGTCTGTCTACATACTACGCA6ACTCC6T6AA66GCCG6TTCACCATCTCCC6C6ACMTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGA6GATACCGC6GfATATTACTGTGCGAAAGGTAGGATTCCT6G6CTGGTTT TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 623) BNS3h-3 GAGGTGCA6CTGTTGGAGTCTGGGGGAG6CTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCT6TGCAGCCTCC6GAT TCACCTTTGGT6ATGCGGC6ATGACTTGGGTCCGCCA66CTCCA66GAAG6GTCTAGAGTGG6TCTCAGCGATTCAGCC TATGGGTGATGGTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCGTCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAAT6MCAGCCTGC6TGCCGAGGACACCGC6GTATATTACTGTGCGAAAGGGCGTATTCCTACTCTTCAGT TT6ACTACT6G6GTCA6GGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO： 624) BMS3h-4 GAGGTGCAGCTGTTGGAGTCT6GGGGAGGCTTGGTACAGCCTGGGGG6TCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTGA66ATTC6CCTAT6ACTTG6GTCCGCCA66CTCCAG6GAAG6GTCTAGAGTGGGTCTCAGCTATTACTTC GAATGGTTATGA6ACATACTACGCAGACTCC6T6AAGGGCC6GnCACCATCTCCCGC6ACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGCGTATTCCTACTCnCAn TTGACTACTG666TCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 625) 86-
163920.doc 201245225 BMS3h-5 GAGGTGCAGCTGTTGGAGTCTGGGGQ^GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGATGAGCATGATATGAGTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACGTATTGGTCC GGATGGTTTTCATACATACTACGCA0^CTCCGT6AAG66CC6GTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATAmCTGTGCGAAAGGGCGTATTCCTACTCTTCATT TT6ACTACTGeGGTCAGGGAACCCTG(；TCACCGTCTCGAGC (SEQ ID NO： 626) BMS3H-6 GAG6TGCAGCTGTTGGAGTCTGGGG6yiGGCTTG6TACAGCCTGGGGGSTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTGGTGAGTATCATATGTCTTGGGTCCGCCAG6CTCCAGGGAAGGGTCTAGAGTG6GTCTCAAG6ATTACTCC TCTTGGTACGCTTACATACTACGCAG/lCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAAnCCAAGAACACGCTG 了 ATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATAHACTGTGCGAAAGGGCGTATTCCTTCGCnACGT TTGACTACTG6GGTCAGGGAACCCTG(iTCACCGTCTCGAGC (SEQ ID NO： 627) BMS3h-7 GAGGTGCAGCTGTTGGAGTCTGGGGG/iGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGGTACGAATGCGATGAGTT6GGTCCGCCAG6CTCCAGGGAAGGGTCTG6AGTG6GTCTCAAG6ATTTCGCC GG6TGGTGATTATACATACTACGCAG/ICTCCGTGAAGG6CC6GTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGC6GTGTATTACTGTGCGAAAGGGCGTGTTCC6GATCTGCTTT TTGACTACT6GGGTCA6GGAACCCTG(；TCACCGTCTCGAGC (SEQ ID NO： 628) BMSBh-8
GAGGTGCAGCT6TT6GAGTCTGGGGGAGGCTTGGTACAGCCT6GG6GGTCCCTGCGTCTCTCCTGTGCAGCCTCC66AT TCACCTTTCC6TCTGAGGAGATGTCTT6G6TCCGCCAGGCTCCAGGGAAG6GTCTASAGTGGGTCTCAAGGATTTCG6C TGATGGTGCTAATACATACTACGCAG/.CTCCGTGAAGGGCCG6TTCACCATCfCCC6C6ACAATTCCAAGAACAC6CT6 TATCTGCAAAT6AACAGCCT6C6TGC(：GA6GACGCCGCGGTATATTACTGTGCGAAAGGGCGTGTTCCGGATCTGCTTT TTGACTACTGGGGTCAGGGAACCCTGCiTCACCGTCTCGAGC (SEQ ID NO： 629) BMS3H-9 6AGGTGCAGCTGHG<3AGTCTGG(566A(3GCHGGTACAGCCTGGG<3GGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGC 下 C5AG6AT<3ATATGACTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTG6GTCTCACGTATTGCGGT TGATGGTGATCGGACATACTACGCAG^.CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA<5CCTGC6TCC(:GAGGACACCGCGGTATATTACTGTGCGAAA(3GTAAG6TTCC6TCTCTTCAH TTGACTACTGG6GTCA6GGAACCCT6C.TCACCGTCTC6AGC (SEQ ID NO： 630) BMS3h-10 GAGGTGCAGCTGTT66A6TCTGG66G/.GGCTT6GTACA6CCTG6GGGATCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTAGGACGAT66ATAT6TmGGGTCC6CCAGGCTCCAGGGAA66GTCTA6A6TGGGTCTCACGTAnAC6^ TGATG6TATGAATACATACTACGCAG/.CTCCGTGAAGG6CCGGTTCACCATCTCCC6CGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGGGGACACCGCG6TATATTACTGTGCGAAAGGGGTGACTCC6GATTT6ACTT nGACTACTGGGGTCAGGGAACCCTGCTCACCGTCTCGAGC (SEQ ID NO: 631) BMS3h-ll 6A6GT6CAGCTGTTGGAGTCTGGGGG/S.GGCTTG6TACAGCCTG66GGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGCGTGAT6ATAT6AC6TGGGTCCGCCAGGCTCCAGGGAAG6GTCTA6AGTGGGTC 丁 CACGTATTAATGC TG66G6T6T6CATACATACTACGCAGi.CTCCGT6AAGG(5CCGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGGGGTGACTCCGGATTTGACTT TT6ACTACTGGGGTCAGGGAACCCTGCTCACCGTCTCGAGC (SEQ ID NO: 632) 163920.doc •87· s 201245225 BMS3H-12 GAG6TGCAGCTGTTGGA6TCTGGGGGA6GCTT66TACA6CCTG6G66GTCCCTGC6TCTCTCCT6T6CAGCCTCC6GAT TCACCTTT6ATGATGATTCTAT6AC6TG6GTCC6CCA66CTCCAGGGAA6GGTCTAGAGTGGGTCTCACGGATTTC6A6 TGATGGTGCGAGTACATACTACGCA6ACTCCGTGAAGGGCCGG 了了 CACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGT6CC6A6GACACC6C66TATATTACTGTGCGAAAGGGGTGACTCCGGATTTGACTT TTGACTACTGGGGTCAG6GAACCCTG6TCACC6TCTC6A6C (SEQ ID NO： 633) BMS3H-13 GAGGTGCA6CT6TTG6AGTCTGGGG6AGGCTTGGTACAGCCTG6GGGGTCCCT6CGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTACTGAGGAGGATATGACGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACGTATTGATAG TGTTGGTGAG6GGACATACTACGCAGACTCC6TGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CT6 TATCTGCAAAT6AACAGCCTGC6TGCCGAGGACACCGCGGTATATTACT6TGCGAAAG6G6T6ACTCCGGATTTGACTT TTGACTACTGGG6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 634) BMSBh-14 GAG6TGCA6CT6TTGGAGTCTGGGG6AGGCTTG6TACAGCCTG6GGGGTCCCT6C6TCTCTCCT6TGCAGCCTCC6GAT TCACCTTTTCTGATTCGGCGATGAGTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACGGATTGATAA TCCTG6TCAGCATACATACTACGCA6ACTCC6TGAAG66CCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCCTGCCGAG6ATACCGCGGTATATTACTGTGCGAAAGGTACT6TTCCTACGCTGGAG 丁 TTGACTACTGGGGTCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 635) BMS3h-15 GAGGTGCAGCT6TTGGAGTCT6GGG6AGGCTTGGTACAGCCT6GGG6GTCCCT6C6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTGGGCAGCATAGTATGACTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACGTATTGATGG TGGGGGTTATAATACATACTACGCA6ACTCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCC6A6GACACCGCGGTATATTACTGTGCGAAAG6GGAGGTTCCTCGTCTTCATT TTGACTACTG6GGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 636) BMS3h-16 GAGGTGCA6CTGTTG6AGTCT66GGGAGGCTT6GTACA6CCT66GGG6TCCCTGC6TCTCTCCT6TGCAGCCTCCG6AT TCACCTTTGG 丁 CAGGAGCCTATGACTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACGGAHGCGTA TAATGGT6GT6ATACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAG6ACACCGCGGTATATTACTGTGCGAAAGGGATTACTCCTAATTTGACTT TT6ACTACTGG66TCAGG6AACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 6B7) BMS3h-17 GAGGTGCAGCTGTT66AGTCTGGGGGAGGCTTG6TACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGA6AATTATCCGATGTCTTGGGTCC6CCAG6CTCCAGGGAAGG6TCTAGAGT666TCTCACGTATTAATGC TACGGGTTaATTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGGTTATTCCTCAmGATG 丁 TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTaCGAGC (SEQ ID NO： 638) BMS3h-18 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGTGATTATGATAT6AGTTGGGTCC6CCAGGCTCCAGGGAAGGGTCTAGAGTG66TCTCAC6TATTACTGG TACTGGTAATAGTACATACTAC6CAGAaCC6T6AAGGGCCGGTTCACCATCTCCC6C6ACAATTCCAA6AACAC6CT6 TATCT6CAAAT6AACAGCCTGCGTGCCGA6GACACCGC6GTATATTACT6TGC6CAAGGGGT6GTGCCGTATCTT6CTT TTGACTACTGGG6TCA6GGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 639) 88-
163920.doc 201245225 BMS3h-19 GA6GTGCAGCT6TT66A6TCTGGGGGyi66CTTG6TACA6CCTGGGGGGTCCCT6CGTCTCTCCTGT6CA6CCTCCGGAT 了 CACaTTGAGGCTGATGCGATGACGVGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTCGGTCTCAAGGAHAATCT 6GAT6GTGATCG6ACATACTAC6CAG/VCTCC6TGAAGGGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCOTGC(：GA6GACACC6C66TATATTACTGTGC6AAA6GTACTGTTCCTACGCTGGAGT TT6ACTACTG6GGTCAGG6AACCCTG(iTCACCGTCTCGAGC (SEQ ID NO： 64Θ) BMS3h-21 GAG6TGCAGCTGTTG6AGTCT6GG66/\GGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGT6CAGCCTCC6GAT TCACCTTT6ATCG66C6GATAT6ACGrGG6TCCGCCA66CTCCAG6GAAGG6TCTAGAGTG6GTCTCAAGGATTTCGGG G6AGGGTAA6TGTACATACTACGCAG/(CTCCGTGAAGG6CCGGTTCACCATCTCCC6C6ACAAnCCAAGAACACGCT<3 TATaGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGATGGTTCCTAATTTGGTTT TTGACTACTGGG6TCAGGGAACCCT6(iTCACC6TCTCGA6C (SEQ ID NO: 641) BMS3h-22 6AGGTGCAGCTGTTGGAGTCTGGG6G/\GGCTTG6TACA6CCTG6GGG6TCCCTGCGTCTCTCCT6T6CAGCCTCCG6AT TCACCTTTCAnGGGAGCCGATGTCTTGGGTCC6CCA6GCTCCGGGGAAGGGTCTA6AGTGGGTCTCACGTATTAATTC TTCTGGTTGGGATACATACTACGCA6/iCTCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATAHACTGTCCGAAAGGGATCGT 了 CCTAATTTGGTTT TTGACTACTGGGGTCAGGGAACCCTGCrrCACCGTCTCGAGC (SEQ ID NO: 642) BMS3h-24
6A6GTGCAGCTGTTGGAGTCTGGGGG；iGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTCTGCA6CCTCCGGAT TCACCTTTGCTGATGAGCCGATGACTTG6GTCCGCCAGGCTCCAGGGAAGG6TCTAGAGTG6GTCTCACGTATTCCTCC TGAG6GTGCTCC6ACATACTACGCAGACTCC6T6AA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGMCACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGATTACTCCTAATTTGACTT TTGACTACTGGGGTCAGGGAACCCTGCiTCACCGTCTCGAGC (SEQ ID NO： 64B) BMS3h-26 GAGGTGCAGCTGnGGAGTCTGGGGG/^GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCATAATCATGATATGTCTTGGGTCCGCCAGGCTCCAGGGAAG6GTCTAGA6T66GTCTCACGTATTAGTCG GGGTGGTCTTCAGACATACTACGCAG/^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAAnCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGATTGTGCCGGATCTGCATT TTGACTACTGGGGTCAGGGAACCCTGCiTCACCGTCTCGAGC (SEQ ID NO： 644) BMS3h-27 GAGGTGCAGCTGTTGGAGTCTGGGGG/^GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTAATGAGTATCCTATGTCGTGG6TCCGCCAG6CTCCA66GAAGGGTCTAGAGTG6GTCTCACGTATTAATG6 GGATGGTGCTAATACATACTACGCAGACTCC6TGAAGGGCC66TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGC(：GAGGACACCGCG6TATATTACTGTGC6AAAGG6ATTATTCC66CTAT6CAGT TTGACTACTGGG6TCAGGGAACCCTGC.TCACC6TCTC6AGC (SEQ ID NO： 645) BMS3h-28 GAGGTGCAGCT6TTGGAGTCTGGGGG/lGGCTTGGTACAGCCT6G6GGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGGGGATGTGCCTATGTCGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAAGGAUGATCC TTATGGTTCTAATACATACTAC6CAG/£TCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACA6CCT6CGT6C(：GAG6ACACCGCGGTATATTACT6TGCGAAAG6TATTAT6CCTA6TCTTACTT TTGACTACTGGGGTCAGGGAACCCTGCrrCACCGTCTCGAGC (SEQ ID NO: 646) 89· 163920.doc 201245225 BM53h-29 6AGGTGCAGCT6TTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTT6CGGATTATGATATGTCTTGG6TCCGCCAGGCTCCAGG6AAGGGTCTAGAGT6GGTCTCACGTATTTC6GC GCTTGGTGCTACTACATACTACGCA6ACTCCGTGAAGGGCC66TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGTCAGCTTCCGGCGTTGGAGT TTGACTACTG6G6TCA6GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 647) BMS3h-30 GAG6TGCAGCTGT 了 GGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTAAGCGTTATTATATGACTTGGGTCCGCCAGGaCCAGGGAAGGATCTAGAGTGGGTCTCAGGTATTGTTCC TTCTGGTAATAGGACATACTACGCAGACTCCGTGAAGGGCCGOTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGTGCCGAG6ACACC6CGGTATATTACTGTGCGAAAGGTAGGATTCC6GATCT6CATT TTGACTACT6GGGTCA66GAACCCTGGTCACC6TCTC6AGC (SEQ ID NO: 648) BMS3h-31 6AGGTGCAGCT6TTGGAGTCTG6GG6A66CTTGGTACAGCCT6G6GGGTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTGCTGATTATGATAT6ACTT6GGTCCGCCA6GaCCAGGGAAGG6TCTA6A6TGGGTCTCAAG6ATTTCTCC GACGG6TG6GCAGACATACTACGCA6ACTCCGTGAAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACC6CGGTATATTACTGTGCGAAAGGTGTTATTCCGTATTTGTCTT TTTCTCCGTTTGACTACTGGGGTCAGGGAACCaGGTCACCGTCTCGAGC (SEQ ID NO： 649) BMSBh-32 GAGGTGCAGCTGTT6GA6TCTGGGGGA66CTT6CTACAGCCTGG6GG6TCCCTGC6TCTCTCCT6TGCA6CCTCCGGAT TCACCTTTTCTAAGTATTGGAT6G6TTGGGCCCGCCAG6CTCCA6G6AAGG6TCTAGAGTG66TCTCATCGATTGATTC 6CATGGTGCTG6TACATACTACGCA6ACTCC6TGAAGG6CCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCT6 TATCT6CAAAT6AACAGCCT6CGT6TCGAG6ACACCGC6GTATATTACTGTGCGAAAG6TGCTCCTAA(mrTATGACTA CGTATACGTTTGACTACTGGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 65Θ)
BMS3h-3B 6AG6T6CAGCTGTTGGA6TCTGGG66AG6CTTGGTACAGCCTGGG6GGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTTTGTCTTATCCGATGCATTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCGATTGATTC GAGGGGTTCGGTTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGA66ACACCGC66TATATTACTGT6C6AAAGGTCATAGTT66AC6TTT6ACT ACT6GGGTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 651) BMS3h-B4 GAG6TGCA6CTGTTGGA6TCT6GGG6AGGCTT66TACA6CCT6GGG6GTCCCTGC6TCTCTCCTGTGCAGCaCCGGAT 了 CACCTTTGCGAATAGTAATAT6ACTTG6GTCC(3CCAGGCTCCAGGGAAGGGTCTA6A6TG6GTCTCAC6TATTAATCC GGATGGTGGGTCTACATACTAC6CAGACTCCGT6AAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCT6 TATCTGCAAATGAACA6CCT6C6T6CCGA6GACACCGCG6TATATTACTGT6CGGAAG6GC6TATTCCTACTCTTCATT TT6ACTACT666GTCA66GAACCCTG6TCACCGTCTC6AGC (SEQ ID NO: 652) BMS3H-35 GAGGTGCAGCTGTTG6AGTCTGGGG6AGGCTTGGTACA6CCTGG6GGGTCCCTGC6TCTCTCCTGTGCA6CCTCCGGAT TCACCTTTGGGCCGAGGAGGATGG6TTeGOTCCGCCAGQCTCCAG6GAAGGGTCTA6AGTGG6TCTCATCGATT6AT6A TATT6GTCGTA66ACATACTAC6CA6ACTCCGTGAAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGAG6ACACC6C6GTATATTACTGTGC6GAAGGGGCGCAG6GTGT6TT6TT6T TT6ACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 653) 90·
163920.doc 201245225 BMS3h-36 6AG6T6CA6CT6TTGGA6TCT66GG(；A66CTT6GTACAGCCTGG6GG6TCCCTGCGTCTCTCCT6T6CAGCCTCCGGAT TCACCTTT6AGGATTATAG6ATG6nT6GGTCCGCCAGGCTCCA66GAA6GGTCTA6A6TGGGTCTCATCGATTTCTAC TTCTGGTGAGa6ACATACTACGCACiACTCCGTGAAGGGCC6GTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGT6CC6A66ACACCGCGGTATATTACT6T6CGGAAACGGCGGGTCA6mTTT6ACT ACTGGGGTCAGG6AACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 654) BMS3h-39 6AG6TGCAGCTGTTGGA6TCTGGGGCAG6Cn66TACA6CaGGG6GGTCCCTGCGTCTCTCCT6T6CA6CCTCC6GAT TCACCTTTCCGGA6TATGAGATG6nTGGGTCC6CCA66CTCCA6GGAAGGGTCTG6A6TGG6TCTCAGCGATTTC6CG TGAGGGTCGG6CTACATACTACGCA6ACTCC6T6AAG66CC66TTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAACCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGAGCCTGTTCGTTTTGACTACT GGG6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 655) BMS3h-40 6AGGTGCAGCT6TTGGA6TCTG6G66AGGCTTGGTACAGCCTGG6GGGTCCCT6CGTCTCTCCTGT6CAGCCTCCGGAT TCACCmTCGACTTATGAGAT6CTTTG66TCCGCCAGGCTCCA6GGAA6G6TCTAGAGT6GGTCTCATCTATTTCTTC TTCT66TAATTATACATACTACGCAGACTCCGTGAAGGGCC66TTCACCATCTCCC6CGACMTTCCAAGAACACGCTG TATCT6CAAATGAACA6CCTGCGTGCCGAG6ACACCGCGGTATATTACT6TGCGAAAGAGCCGCTGAT6TTTGACTACT 6GGGTCA6G6AACCCT66TCACCGTCTC6AGC (SEQ ID NO: 656) BMS3h-42
GAG6TGCAGCTGTTGGA6TCTG6GGGiVGGCTTGGTACAGCCT6GGGGGTCCCT6CGTCTCTCCT6T6CA6CCTCC6GAT TCACCTTTGATACTGAGGAGATGAGTrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCGATTAGTCC TAATGGTGCTTTTACATTCTACGCAa^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCCTATTCTGTTTGACTACT G666TCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 657) BMS3h-44 GAGGTGCAGCTGTT6GA6TCT6G6G6AG6CTT6GTACA6CCTGGG6GGTCCCT6C6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGGTCATTATGATATGGTTTGGGTCCGCCAGGCTCCAGGGAGGGOTCTAGAGTGGGTCTCAACTATTAATGG 丁 GCTGGTCTGAATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAAHCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCOTGC<：6AGGACACC6CGGTATATTACT6TGCGCAAA6T6CTAGTCGTATTTTT6ACT ACTGGGGTCAGGGAACCCTGGTCACC(；TCTCGAGC (SEQ ID NO: 658) BMS3h-45 GAGGTGCAGCT6TTGGAGTCTGGGGG/VGGCTTG6TACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTAGGAGTTATGA6ATGGCGTG6GTCCGCCAGGCTCCAGGGAAGGGTCTAGA6T6G6TCTCATCTATTAGTAC TCTG6GTACGAAGACATACTACGCAG>VCTCCGTGAAGGGCCGGTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCT6CAAAT6AACAGCCTGC6TGC(：GAGGACACC6CGGTATATTACT6TGCGCAATCTTCTACTCATATTTTTGACT ACT6GGGTCAGGGAACCCTGGTCACC(iTCTCGAGC (SEQ ID NO: 659) BMS3h-46 '
GAGGT6CAGCTGTTGGAGTCTGGGGG/VGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCC6GAT
TCACCTTTATTA6GTATGAGATGGCTTGGGTCC6CCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAAOTATTTC6TC
GTCTGGTTG6AC6ACATACTACGCA6ACTCCGTGAAGG6CC6GTTCACCATCTCCC6C6ACAATTCCAA6AACACGCTG
TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAAGTGATGCTCATATTTTTGACT ACTGGGGTCAGGGAACCCTGGTCACCCiTCTCGAGC (SEQ ID NO: 66Θ) 91- 163920.doc 201245225 BMS3h-47 GAGGTGCAGCTGTTGGAGTCTGG6G6AGGCn6GTACAGCCTGGGG66TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTTATGCTTAT6A6ATGGCTTGGGTCCGCCAGGCTCCA6GGAAGGGTCTAGAGTGG6TCTCATCTATTTCG6A 了 GATGGTACGCGGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6C6TGCCGA6GACACC6C66TATATTACTGTGCGAAA6ATCT6GGGCAGGGGTTT6ACT ACTG66GTCAGGGAACCCT66TCACC6TCTCGA6C (SEQ ID NO: 661) BMS3h-48 GAG6T6CA6CT6TTGGAGTCTGG6G6AGGCTTGGTACAGCCTG6GG6GTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTn6CTGATCATGG6AT6ACGTGGGTCCGCCAG6CTCCAGGGAAGGGTCTAGAGT66GTCTCAGG6ATTGGTCC 6TCTGOTGAGGCGACATACTACGCA6ACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCT<3 TATCTGCAAATGAACAGCCTGCGTCCCGAGGACACCGCGGTATAHACTGTGCGAAAGATCGTATTCCTAATOTGTG 丁 TTGACTACTG6GGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 662) BMS3H-49 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTG6G6GGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6AGTCTCAGGATAT6TCTTGG6TCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCA6GTATTAGTCC GAATGGTTGGGATACATACTACGCAGAC 了 CCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGCTATATTACTGTGCGAAAGATAGGTCTGATTTTGACTACT GGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 663) BMS3h-50 GA6GTGCA6CTGTTGGAGTCTGGG6GA6GCTT6GTACAGCCTGGGGG6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6GGGATTATGATAT6TGGTGGGTCCGCCAGGCTCCAGG6AAGGGTCTAGAGTGGGTCTCAAG6ATTCGTCA 丁 CCGGGTGGTGTTACATACTACGCAGAtTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGAGGACACCGCG6TATATTACTGTGCGAAAGCTGTTCCTAAGG(irmGACT ACTGG6GTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 664) BMS3h-51 GAGGTGCAGCTGTTGGAGTCTGGG6GAGGCTT6GTACA6CCTGGG6GGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTCGGGTTTATTGGATGACTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTGATCC GCAGGGTG6GAT6ACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCTCGCGACAATTCCAA6AACAC6CTG TATa6CAAATGAACAGCCTGC6TGCCGAGC5ATACCGCGOTATATTACT6TGC6AAAGCGC6TATTCCTAATTT66A6T TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 665) BMS3h-52 GAGGTGCAGCTGTTGGAGTCTGGG6GAGGCTTGGTACAGCCT6GGGAGTCCGTGCGTCTCTCCTGTGCA6CCTCCGGAT TCACCTTTAGT6CTTATGATATGACGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTT6AGTGGGTCTCAC6TATTAATCC GACGGGTTCTTATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATaGCAAATGAACAGCaGCGTGCCGAGGATACCGCGGTATATTACTG 丁 GCGAAAGCTAAGATTCCGAATTTGGm nGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 666) BMS3H-53 GAGGT6CAGCTGTT6GAGTCTGGGG6AGGCTT6GTACA6CCTGGG666TCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGC6GATAGTGAGATGAT6TGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGGTATTGC6CA TAAT66TGGGCATACATACTAC6CAGACTCCGTGAAGG6CCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGCTG6TCATCCTCA6CAGACTG AGGCTTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 667> 92·
163920.doc 201245225 BMSBh-54 6AGATGCAGCT6TT66AGTCTG6GG6AGGCTT6GTACAGCCTGGGGGGTCCCT6C6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGCTACTTAT6ATAT6TATT6GGTCCGCCAGGCTCCAGGGAA6GGTCTA6AGTGGGTCTCAAAGATTTCTCC 6AAT6GTTGGAGTACATACTAC6CA6ACTCCGTGAA6GGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAATATCAGACGCATTTTCSACTAC 丁 G6GGTCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 668) BMS3h-55 GA6GTGCA6CT6TT6GA6TCTGG6GG^G6CTT66TACAGCCTGGGGGGTCCCTGCGTCTaCCT6TGCAGCCTCCGGAT TCACCTTTAGTGTTTATGATATGA6GrGGGTCC6CCAGGCTCCAGGGAAGGGTCTAGA6TGGGTCTCAACGATTTCTTC TTCGGGTACGTATACATACTAC6CAGACTCCGT6AAGG6CCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGC:GAGGACACCGCG6TATATTACTGTCCGAAATATCCTAAGAATTTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 669) BMS3h-57 GAGGTGC^GCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTTCTCATGAG6ATATGACTr6G6TCC6CCA66CTCCAGGGAAGGGTCTAGAGTGGGTCTCAAGTATTAGTCC GAATGGTTGGGATACATACTACGCAa^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACGTACTAGGAGTAAGTTTGAC 丁 ACTGGGGTCAGG6AACCCTG6TCAC03TCTC6AGC (SEQ ID NO: 670) BMS3h-58
GAGGTGCA6CTGTTGGAGTCT66GG6j\GGCTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGAAGTATATTAT6G6TrG66CCCGCCAGGCTCCAGGGAA6GGTCTAGAGT66GTCTCAACGATTGATTA TTGG66TCAGCATACATACtACGCAG\CTCCGTGAAGG6CCGGTTCACTATCTCCC6CGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACGTAGTCATCrTATTCCTCTGC AGTTTGACTACTGGGOTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 671) BMS3h-59 6AGGT6CAGCTGTTGGAGTCTGG6GG)\GGCTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCT6TGCAGCCTCCG6AT TCACCmTCTGATTATGCGATGGGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCAACGATTTCCTA TGTGGGTTATTATACATACTACGCAGAarCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCG 丁 GCCGAGGACACCGCGGTATATTACTGTCCGAAAAAGGCTCTGCGGGGGGAGGCOT TTACGGAGC6TTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 672) BMS3h-60 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGGTCC<3TATATGAT6CAr-6GGTCCGCCAGGCTCCA6GGAA6GGTCTAGAGTGGGTCTCAACGATT6AG6T TAAT66TAATAGGACATACTACGCAGACTCC6TGAAGGGCCeGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCT6CAAATGAACAGCCT6CGT6CC6AGGACACCGCGGTATATTACTGT6C6AAATGGGTTGGTTCGAAGAC6TCGT CGGATAAGA6TTTTGACTACTGG66T(^GGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 67B) BMSBh-61
6AG6TGCAGCTGTTGGAGTCTGGG6GAGGCTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCC66AT 丁 cacctttggtacgamgagAtggcttgggtccgccaggctccagggaagggtctagagtgggtctcaagtattggtag TGCTGGTGCTTGGACATACTACGCAGAC 丁 CCGTGAAGGGCCGCTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTOTGCGAAAATTGGTGGGCATCCTCAGGGTC A6TTTGACTACTGGGGTCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ 10 NO: 674) 93- 163920.doc 201245225 BMS3h-62 GAGGT6CA6CTGTTGGAGTCTGG6GGAGGCTTGGTACA6CCTGGGGGGTCCCTGCGCCTCTCCTGT6CAGCCTCCGGAT TCACCTTTCCTAGG6AGTG6AT6GCTTGGGTCC6CCA6GCTCCAG6GAAGGGTCTAGAGTGGGTCTCAAGTATTCA6CC TATG6GTCAGACTACATACTACGCAGACTCCGTGAAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCT6C6T6CCGAGGATACC6CGGTATATTACTGTGCGAAATAnCTCGGAATAAGGGGTTTT TTGACTACTGGGGTCAGG6AACCCT6GTCACCGTCTC6A6C (SEQ ID NO: 675) BMS3h-63 GA6GT6CAGCTGTTGGAGTCTG6GG6AGGCTTG6TACA6CCT6GGGG6TCCCTGCGTCTCTCCT6T6CAGCCTCCGGAT TCACCTTTAC6AGTGAGTATATGG66T666TCCGCCA66CTCCA6GGAAGG6TCTAGA6T6GGTCTCATCTATTCAGAG GTAT6GTAGTACGACATACTACGCA6ACTCC6T6AA6G6CC6GTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAMTGAACAGCCTGC6T6CCGAG6ATACC6CG6TATATTACT6TGCGAAACAT6AGTCTAATTGGGAGACTT TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 676) BMS3H-70 ·
GAGGTGCA6CTGTTGGAaTCT6G6GGAGGCTTGGTACAGCCT6G6GGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT
TCACCTTTTCGGTGTATAGTATGCAGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCGATTACTCC
TAATGGTACTCGGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG
TATCTGCAAATGAACA6CCTGCGT6CC6AGGACACCGC66TATATTACTGTGCGAAAACTCTTGGTC6GGGTTCTTATC CTGGTGTTGATTTTGACTACTGGG6TCAG6GAACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 677) BMS3h-71 G如 GTGCAGCTtnTGi^GTCTGGGGGAGGCTTGGTACAaCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCCGA6TTAT6CTATGAC6TGG6TCCGCCAG6CTCCAGGGAA6GGTCTGGAGTGG6TCTCACGTATTAC66C GGATGCTACTGmCATACTACGCAGACTCCGTGMGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCT6CGT6CC6A6GACACCGC6GTATATTACT6TGCGAAAGGirTCTATTCCGAT6CTTACGT TTGACTACT666GTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 678) BMS3h-72 GAGGTGCAGCTGTTGGAGTaGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCmrTCGACTTAT6ATAT6ATTT6GGTCCGCCAeGCTCCAG6GAAG6GTCTAGAGTGG6TCTCA6CTATTTCTCC TAATGGTACTGGTATATACTAC6CAGACTCCGTGAA6G6CCGGTTCACCATCTCCC6CGACAATTCCAAGMCACGCTG TATCTGCAAATGAACAGCCTGC6T6CCGAGGACACC6C6GTATATTAaGTGCGAAAAATCA6A6T6TTCATCATGCT6 TTTTTGACTACTGGG6TCAGGGAACCCTGOTCACCGTCTC6AGC (SEQ ID NO: 679) BMS3H-73 GAGOTGCAGCTGTTGGA6TCTGGGGGAGGCTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCC 下 GTGCAGCCTCCGGAT TCACCTTT6A6AATTAT6AGATGAC6TGGGTCCGCCAGGCTCCAGG6AAG66TCTA6AGTGGGTCTCAC6TATT6CGCC GCATGGTCGGCTTACATACTACGCAGACTCCGTGAAG66CCG6TTCACCATCTCCCGC6ACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGG 了 ATATTACTGTGCGAAAGGTCAGATTCCGATGCTTGATT TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 680) BMS3K-74 GAGGTGCAGCTGTT6GAGTCTGG666A6GCTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCA6CCTCC6GAT TCACCTTTTCGCATTATAT6ATGATGTGGGTCCGCCA6GCTCCAGG6AAGG6TCTAGAGTGGGTCTCAAC6ATTTCTCA TTTTGGTGATATTACATACTACGCAGACTCC6TGAAGGGCC6GTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATAHACTGTGCGAAAAATGATATGGTGATGAAGAATG GGGGGTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID. NO； 681) 94-
163920.doc 201245225 BMS3H-75 GAG6TGCAGCTGTTG6A6TCTGG66GAG6CTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6A6AGGTATGATAT6A6TT6GGTCCGCCAGGCTCCAGGGAA6GGTCTAGAGTGGGTCTCACGTATTGATTC GCGGGGTT6GTCTACATACTAC6CAGftCTCCGTGAAGG6CCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGC：6AGGACACCGCGGTATATTACTGTGC6AAAGGGTTGGTGCC6CATCTGAGGT TTGACTACTGGGGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 682) BMS3h-76 GAGGTGCAGCT6TTG6A6TCTGGGGGi\GGCTTGGTACAGCCTGGG6GGTCCCT6CGTCTCTCCTGT6CA6CCTCCGGAT TCACCTTTGCGAATGCGCAGAT6ACTrGGGTCCGCCAGGCTCCAGGGAAG6GTCTA6AGTGGGTCTCAAG6ATTGATGC TATGGGTGATGCTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGC：GAGGACACCGCGGTATATTACTGT6CGAAA66TAAGGTTCC6AGTATTGACT ACTGGGGTCAGGGAACCCTGGTCACC3TCTCGAGC (SEQ ID NO： 683) BMS3h-77 GAGGTGCAGCTGTTGGAGTCTGGG6a^6CTTGGTACAGCCT6GGGG6TCCCT6C6TCTCTCCTGT6CA6CCTCCG6AT TCACCTTTGCGAATGCGCAGATGACTT6GGTCC6CCA6GCTCCAGGGAA6GGTCTAGA6TGGGTCTCAAGGATTGATGC TAT6GGT6ATGCTACATACTACGCAG!VCTCC6T6AA6G6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG 了 ATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGGTGTTATTCCGGCGTTTGACr ACTGGGGTCAGGGAACCCTGGTCACCOTCTCGAGC (SEQ ID NO： 684) BM53h-78
GAG6TGCAGCTGTT6GAGTCT6GGGG>\6GCTTGGTACAGCCTGGG(3G6TCCCT6CGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTTCAGAATGATCGGATGCATT6GGTCCGCCAGGCTCCAGG6AA66eTCTA6AGTGGGTCTCATCGATTTCTCC TACTG6TGGT6ATACATACTACGCA6ACTCCGT6AA66GCC66TTCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCC6AGGACACCGCGGTATATTACT6TGCGAAACAGACG66TAC6AATCGmT6 ACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 685) BMS3h-79 GAGGTGCAGCTGTTGGAGTCTGG6GG>\GGCTT6GTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTAATCAGCCTTATATGTCGTGGGTCCGCCA6GCTCCAGGGAAGGGTCTGGA6TG6GTCTCATCTATTGAT6C TTCGGGTG6TACTACATACTACGCAG>^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACGCCGCGGTATATTACTGTGCGAAAGATCGTATTCCTAATCTTGTGT TT6ACTACTGGGGTCAGGGAACCCT6<rrCACC6TCTCGAGC (SEQ ID NO: 686) BMS3h-80 GAGGTGCAGCTGTTGGAGTCTGGG6G>^GCTTGGTACAGCj：TGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTGATAAT6AGAATATGACT1-GGGTCC6CCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACGTATT6AT6G TG<36GGTTATAATACATACTAC6CAGivCTCCGTGAA6GGCC6GTTCACCATCTCCC6C6ACAATTCCAAGAACACGCT6 TATCTGCAAATGAACA6CCTGCGT6C<：GA6GACACCGCGGTATATTACT6TGCGAAA6GGCAGGTTCCTGAGCTGCTGT nGACTACT6GGGTCAGG6AACCCT6(iTCACCGTCTCGAGC (SEQ ID NO： 687) BMS3h_81 GAGGTGCAGCTGTTGGAGTCTGGGG6AG6CTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGTTTCGTCGAATATGACTI'GGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTGG TA6T6GTGGTAGCACATACTATGCAG/VCTCCGTGAAG6GCCGGTTCACCATCTCCC6CGACMTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTAC 了 GTGCGAAAGGTCGGATTCCTACGTTGGTGT TTGACTACTG6GGTCAGGGAACCCTG(iTCACCGTCTCGAGC (SEQ ID NO： 688) 95· 163920.doc 201245225 BMS3h-82 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCiCCTGTGCAGCCTCCGGAT TCACCTTT6TTTC6TCGAATAT6ACTT6GGTCC6CCAG6CTCCA6GGAA6G6TCTAGA6TG66TCTCAGCTATTAGT6G TAGTGGTGGTAGCACATACTATGCAGACTCCGTGAAGGGCCGGUCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGTGCCGA6GACACCGCG6TATATTACTGTGCGAAAGATCGTATTCCTAATCTTGTGT TTGACTACTG6G6TCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 689) BMS3H-83 GAGGTGCAGCTGTTGGAGTCTGGGG6AGGCTTGGTACAGCCTGGGG6GTCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTTTCT6AT6ATTC6AT6A6TTGGGTCCGCCAG6CTCCAGGGAA66GTCTAGAGTGGGTCTCACGTATTAAT6A T6CT6GTAGTTCTACATACTAC6CA6ACTCCGTGAAGG6CC66TTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCT6CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGTACTATTCCTCTTCTG6AGT TT6ACTACTGGG6TCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 690) BMS3H-84 GAGAT6CAGCTGTTG6A6TCTGG6GGAGGCTTGGTACAGCCT6GG6GGTCCCTGCGTCTCTCCTGT6CAGCCTCC6GAT TCACCTTTGTTTC66ATACTATGA6TTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGA6T6GGTCTCAC6TATT6ATG6 GACTGGTGGTGATACATACTACGCAGACTCC6T6AA6GGCC66TTCACCATCTCCCGCGACAATTCCAA6AACAC6CT6 TATCTGCAAAT6AACA6CCTGC6T6CCGG6GACACCGCGGTATATTACT6T6CGAAA6GGCTTATTCCTGATC7TCAGT TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 691) BMS3H-85 GAG6TGCAGCT6TTGGAGTCTGGGGGAGGCTTG6TACAGCCTG66G6GTCCCTGCGTCTCTCCTGTGCA6CaCCGGAT TCACCTTT6ATGAG6AGGA6ATGACGTGG6TCCGCCAGGCTCCAGG6AA6G6TCTA6AGTG66TCTCAC6TATTATTGG TGGTGGTCATGAGACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGAGGACACCGCGGTATATTACT6TGC6AAA66TACTATTCCTCTTCTG6AGT TTGACTACTG6GGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 692) BMS3H-86 6A6GTGCAGCTGTTG6A6TCTG6GG6AGGCTTGGTACAGCCTGGGGG6TCCCT6C6TCTCTCCTGT6CA6CCTCCGGAT TCACCTTT6ATAATGAGAATATGACTTGGGTCC6CCAGGCTCCA6GGAAG6ATCTA6AGT6G6TCTCACG6ATTACTGA GA6GGGT6ATGT6ACATACTAC6CAGACTCC6T6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCCGAG6ACACCGCG6TATATTACT6TGCGAAAG6TACTGTTCCTAC6CT6GAGT JTGACTACT6G66TCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 693) BMS3h-87 GAGGTGCAGCTOTTGGAOTCT 咖 GGAGGCTTGOTACAGCaGGGGGGTCCCTGCGTCTCTCCTCTGCAGCCTCCGGAT TCACCTTTGAT6AGGAGGAGATGACGTGGGfCCGCCAG6CTCCA6GGAAG66TCTAGAGTGGGTCTCACGTATTATT6G TGGTGGTCAT6A6ACATACTACGCAGACTCCOTGAA6GGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG 丁 ATCTGCAAATGMCAGCCTGCGTGCCGAG6ACACCGCG6TATATTACTGTGCGAAAGGTACTGTTCCTACGCTGGAGT TTGACTACT6GGGTCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 694) BMS3h-88 GAGGTGCAGCTGTTGGAGTCTGGG6GAGGCTT6GTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTTCAT6AGACGGAGATGACGTGGGTCCGCCA6GCTCCA6G6AAG6GTCTAGAGTGGGTCTCAGCTATTAATCG GCTGGGTCAGGATACATACTACGCAGAaCCGTGAAGGGCCGG 丁 TCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGMCA6CCTGCGTGCCGAG6ACACCGCGGTATATTACTGT6CGAAA6GTAGGATTCCT6GGCTGGTTT TTGACTACTGGG6TCAGGGAACCCTG6TCACCGTCTCGA6C (SEQ ID NO： 695) 96·
163920.doc 201245225 BMS3h-89 GAGGTGCAGCTGTTGGAGTCTGGGGG^GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTTCTGATGATTCGATGA6TrGGGTCC6CCAGGCTCCAGGGAAGGGTCTA6AGTG6GTCTCACGTATTAATGA TGCTGGTAGTTCTACATACTACGCA6ACTCCGTGAAGGGCC6GTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGC'：6AG6ACACCGCG6TATATTACTGTGCGAAAGGTACTGTTCCTACGCTGGAGT nGACTACT666GTCAGGGAACCCTG3TCACCGTCTCGAGC (SEQ ID NO: 696) BMSBh-90 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGATAAT6AGAATAT6ACrrG6GTCCGCCA6GCTCCAGGGAAGGATCTAGAGT6GGTCTCACG6ATTACTGA GAGG6GTGAT6TGACATACTACGCAGi\CTCCGTGAAGG6CC6GTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6Ci：6AGGACACCGC6GTATATTACTGTGCGAAAGGTCGGATTCCTAC6TTGGTGT TT6ACTACTGGGGTCAGG6AACCCTGI5TCACCGTCTC6AGC (SEQ ID NO: 697) BMS3h-91 GAG6TGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCA6CCTCCGGAT TCACCTTTTCTGATGATTCGAT6A6TTGGGTCC6CCAGGCTCCAGG6AAGGGTCTA6AGT6GGTCTCACGTATTAATGA TGCT6GTA6TTCTACATACTAC6CA6ACTCCGT6AAG6GCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGATTACTCCTAATTTGACTT TTGACTACTGGGGTCAGGGAACCCTGtiTCACCGTCTCGAGC (SEQ ID NO： 698) BMS3h-92
GAG6TGCAGCTGTTG6A6TCTGGGGG/vGGCTTGGTACAGCCTGG6GGGTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTT6CTGAT6A6CCGAT6ACTT6G6TCCGCCAGGCTCCA6GGAAGGGTCTAGAGTG66TCTCACGTATTCCTCC T6AG66T6CTCCGACATACTACGCAG/iCTCCGT6AAGGGCCG6TTCACCATCTCCC6C6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGCTTATTCCTGATCTTCAG 了 TTGACTACTGGGGTCAGGGAACCCTGCiTCACCGTCTCGAGC (SEQ ID NO： 699) BM53h-93 GAGGTGCAGCTGTTGGAGTCTGGGG6AGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCAGGATAGTGATATGACGT6GOTCCGCCAGGCTCCAG6GAA66GTCTAGAGTG66TCTCAGCTATTGCTGC GCCTGGTGGTAGTACATACTACGCAGiCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGATCGTArrCCTAATCTtAGGT TTGACTACTGGGGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 7Θ0) BMSBh-94 GAG6TGCAGCTGTT66A6TCTGeGGG/iG6CTTG6TACAGCCT666GGGTCCCTGC6TCTCTCCTOTGCA6CCTCC6GAT TCACCTTT6TTTCG6ATACTAT(3A6nGG6TCCGCCAGGCTCCAG6GAA66GTCTAGA6TGG6TCTCAC6TATT6ATGG GACTGGT66TGATACATACTAC6CAGACTCCGTGAAGGGCCG6nCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCC6AG6ACACCGCGGTATATTACT6T6CGAAAGG6CAG6TTCCTGAGCTGCTGT TT6ACTACTGGG6TCA66GAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 701) BMSBh-95 6A6GTGCAGCTGTTGGAGTCTGGGGGAG6CTTG6TACAGCCT6GGGGGTCCCT6CGTCTCTCCTCTGCA6CCTCCG6AT TCACCTTTCAGGATA6T6ATATGACGTGGGTCCGCCAGGCTCCAGGGAA66GTCTAGAGTGGGTCTCAGCTATTGCT6C GCCTG6TG6TAGTACATACTACGCA6ACTCC6T6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCGTAnCCTAATCTTGTGT TTGACTACTGGGGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 702) 97- 163920.doc 201245225 BMS3h-96 GAGGT6CA6CTGTTG6A6TCTGGGG6A66CTTGGTACAGCCTG6666GTCCCTGCGTCTCTCCT6TGCAGCCGCCGGAT TCACCTTTGATCT66C66A6AT6ACTT666TCCGCCAG6CTCCA6GGAAG66TCTA6A6TG6GTCTCACGTATTGAT6A G6AT6GTGCTTCTACATACTAC6CAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGT6CC6AGGACGCCGCGGTATATTACT6TGCGGAA6GTGTTATTCC6TCTCTGACTT TTGACTACTGGG6TCAG6GAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 703) BMS3h-97 GAG6TGCAGCTGTTGGAGTCTGGGGGA6GCTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTACTGATAAGCATATGA6TTGGGTCC6CCAGGCTCCAGGGAAGGGTCTA6A6TGGGTCTCACGGATTTCGCC TGATGGTACGTATACATACTACGCAGACTCCCTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGAGGAC6CC6CGGTATATTACTGTGCGGAAGGTGTTATTCCGTCTCTGACTT TTGACTACTGG6GTCAGGGAACCCT66TCACCGTCTCGAGC (SEQ ID NO： 704) BMS3h-98 6AGGT6CAGCTGTTGGAGTCT6GGG6AG6CTTG6TACAGCCTG6G6GGTCCCTGCGTCTCTCCT6T6CAGCCTCCG6AT TCACmTGCTGAGGATGATATGACrTGG6TCCGCCAG6C 丁 CCAGGGAAGG6TCTAGAGTGGGTCTCACGTATTGCGGT TGAT6GT6ATCG6ACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCT6C6TACCGAGGACACCGC6GTATATTACTGT6C6AAAGG6AA6AC6CCGCATCTTGTGT TTGACTACTGGGGTCAGGGMCCCTG6TCACC6TCTCGAGC (SEQ ID NO： 705) BMS3h-99 6A6GT6CAGCTGTTG6A6TCTG<3GG6AGGCTTGGTACA6CCTGGGG66TCCCT6CGTCTCTCCT6TGCA6CCGCCGGAT TCACCTTTGATCTGGCGGA<SATGACTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGT6GGTCTCACGTATTGATGA 6GATG6TGCTTCTACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCT6CGTGCC6AGGACACCGC6GTATATTACTGTGCGAAAGGTCAGGTTCCTGCTTT6GTTT TTGACTACTGGGGTCAGGGMCCCTGGTCACCGTCTC6AGC (SEQ ID NO： 7Θ6)
BMS3h-10O GA6GTGCAGCTGTTGGA6TCTGGG6GA66CTTGGTACAGCCT6GG66GTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGGATTCGAT6ATGTCGTGGGTCCGCCAGGCGCCA6GGAAGGGTCTAGAGTGGGTCTCACG6ATTGATCC TGGGGGTGCTCAGACATACTAC<3CA6ACTCCGTGAAGGGCCGCTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGG<jGTGACTCCGGATTTGACTT TTGACTACTGG6GTCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 7Θ7) BMS3h-101 6AGGTGCAGCTGTTGGAGTCTGGGG6AGGCTT6GTACAGCCTGGGGGGTCCCT6CGTCTCTCCT6TGCA6CCTCC6GAT TCACCTTTGAGCAT6CGGATATGAGTTGGGTCCGCCAG6CTTCAGGGAA6GGTCTAGAGTGGGTCTCAC6TATTGATAA TA6TGGTCAGTCTACATACTAC6CAGACTCCGTGAA6GGCCG6TTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGOTGACTCCGGAnTGACGT TTGACTACTGGGGTCAG66AACCCTG6TCACCGTCTC6A6C (SEQ ID NO： 7Θ8) BMS3h-102 6AG6TGCAGCTGTTGGAGTCTGG6GGA6GCTT6GTACAGCCTGG6G66TCCCTGCGTaCTCCT6TGCAGCCTCC66AT TCACCTTTAGTGAGGCGGAGATGAATTGGGTCCGCCA6GCTCCA6G6AAGGGTCTAGAGTGGGTCTCACGTATTACGAC G6ATGGTGATTCTACATACTACGCAGACTCCGT6AA6GGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTCTaGAAAGCSGCGTATTCCTACTCTTCATT TTGACTACTGGG6TCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 709) 98-
163920.doc 201245225 BMS3h-103 GAGGT6CAGCT6TTGGA6TCTGGGG(^GGCTTGGTACAGCCTG6GG6GTCCCTGCGTCTCTCCT6T6CA6CCTCA6GAT 了 CACCTTTGATGATAGTGATATGACTTGGCTCCGCCAGGCTCCAGGGAA6AGTCTAGAGTGGGTCTCATATATTCGGGG T6ATGATGATGAGACATACTACGCACIACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGC6T6CC6A66ACACCGCGGTATATTACT6TGCGAAAAATCG6ATTCCTGATCTT6TGT TTGACTACTG6G6TCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 710) BMS3h-108 6AGGT6CAGCTGTTG6AGTCTGGGGGA6GCTTGGTACAGCCT66G66GTCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTAAT6TGGCG6ATATGCACiTG6GTCCGCCAGGCTCCAGGGAAG6GTCTAGAGTGGGTCTCAAGTATTAGTCC GAATG6TTGGGATACATACTACGCA(;.ACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGAGGACACC6CGGTATATTACT6T6C6AAACATGCTTCTACGGAGGGGCCGA CTGCTTTTGACTACTGGGGTCAGGG/ACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 711) BMS3h-l的 6AGGTGCAGCTGTTGGAGTCT6GG6G；AGGCTT6GTACAGCCT6GG6GGTCCCTGC6TCTCTCCTGTGCA6CCTCCG6AT TCACCTTTGGGCC6TATGATATGG(KTGGGTCCGCCAGGCTCCAG6GAAGGGTCTGGAOTGGGTCTCATGGATTTCTGC TCATGGTTCGTTTAGVTACTACGCACiACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGATACC6CGGTATATTACTGT6CGAAATGGCCTTATAAGTTTGACTACT G6GGTCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 712) BM53h-110
GAGGTGCAGCT6TTGGA6TCT6GGGCAGGCTTGGTACAGCCT66GG6GTCCCTGC6TCTCTCCTGT6CA6CCTCCGGAT TCACCTTT(5G(5AGTGG6TCTATGA<51TGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACG(5AHG6TAG TAATGGTGCGGATACATACTACGCAGACTCC6TGAAG6GCCGGTTCACCATCTCCCGCGACAATTCCAA6AACAC6CT6 TATCT6CAAAT6AACA6CCTGCGTGCCGAG6ACACC6CGGTATATTACT6TGC6AAA6GGATGGTTCCTMTTTGGTTT TTGACTACTGGGGTCAGGGAACCCTCOTCACCGTCTCGAGC (SEQ ID NO: 71B) BMS3h-lll GAGGTGCAGCT6TTG6AGTCTGGGGGAGGCTTGGTACAGCCTGGGG6GTCCCTGC6TCTCTCCTGTGCA6CCTCC6GAT TCACCTTTAATCGTTTTGATATGACGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTGG TAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTAaGTGCGAAAGATCGTATTCCTAATCTTGTGT TTGACTACTGGGGTCAGGGAACCCTG6TCACCGTCTC6AGC (SEQ ID NO: 714) BMS3h-112 6AGGTGCAGCTGTTG6AGTCTGGG6GAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCA6CCTCCGGAT TCACCTTTGGGGA6AGTGATATGAAGTGGGTCCGCCAGGCTCCA666AA666TCTAGAGT6GGTCTCAAGTATTA6TCC GAATGGTTGGGATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGMCAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAATCTCCTTCTTCTCGTCTTAAGT TTGACTACTGGGGTCAGGGAACCCT66TCACCGTCTCGAGC (SEQ ID NO： 715) BMS3h-139 GAGGTGCAGCTGTTG6AGTCTGGGGGAGGCTTGGTACAGCCTGG6GGGTCCCTGCGTCTCTCCTGT6CA6CCTCCG6AT TCACCTTTGATAG 丁 AGTGAGATGAGTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCGATTGAGAA TCA6GGT6GTGCGACATACTACGCAGACTCCGT6AA6GGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCC 丁 GCC3TGCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCCTATTCCTMTCTTGT6T TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 716) 163920.doc •99-
S 201245225 BMS3H-140 6AGGTGCAGCT6TTGGAGTCTGG6GGAGGCTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCTGTGCA6CCTCCGGAT TCACCCTTGATGCGTATCCTAT6TATT6G6TCC6CCA6GCTCCAGGGAAGGGTCTAGAGTGGGTCTCATG6ATTGCTTC GGGTG6T66T6C6ACATACTAC6CAGACTCCGT6AAGG6CC66TTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAMTGMCAGCCTGCGT 虹咖 GACACCGCGCTATAUACTGTGCGAAACCTACGMGMmTCACTACT GGGGTCAGGGAACCCT6GTCACCGTCTC6AGC (SEQ ID NO: 717) BMS3h-141 GAG6TGCAGCTGTTGGAGTCTGGG6GAG6CTTG6TACAGCCTGGG66GTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTAT6AGTTATTCTATGGCTTGGGTCC6CCAGGCTCCAGGGAAGGGTCTAGAGTGG6TCTCAGGGATTACTTC TAATGGTAATCGGACATACTAC6CA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAATCGACTGGGGCTAATA6TAGGA ATTTT6ACTACTG6G6TCA6GGAACCCT6GTCACCGTCTC6AGC (SEQ ID NO: 718) BMS3h-142 GA6GTGCAGCT6TT6GAGTCT6GGGGAGGCTT6GTACAGCCTGGGGG6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGGGGTATCTGATGTCGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTaCAAGTAHGCGGC TAATGGTAT6CAGACATACTAC6CAGACTCCGT6AA6GGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCT6C6T6CC6AGGACACC6C<3GTATATTACTGTGCGAAAAA6CCGA666GTATTTffiGATG 6GGATTTTGACTACTG6GGTCAG6GAACCCTGGTCACC6TCTC6AGC (SEQ ID NO： 719) BMS3h-143 GAGGTGCAGCTGnGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCATGA6TCTACGATGACGTGGGTCCGCCAG6CTCCAG6GAAG6GTCTA6AGTG66TCTCAACTATTC66CA TCCGGGTGAGTTTACATACTACGCAGACTCCGT6AAGGGCCG6TTCACCATCTCCC6CGACAATTCCAA6AACAC6CTG TATCTGCAAATGAACAGCCTGC6TGCCGG6GACACCGC6GTATATTACTGTGCGAAAGG6CTTATTCCTGATCTTCA6T TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 720) BMS3H-144 GAGGT6CAGa6TTGGAGTCTGGGG6AGGCTTGGTACA6CCT6GG6GGTCCCTGCGTCTCTCCT6TGCAGCCTCCG6AT TCACCTTTGCGATGTATAGTATGAGTT6GGTCCGCCAG6CTCCAGG6AAG6GTCTAGA6TGGGTCTCATC6ATT6CGCC GCCGGGTGGTAGGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTC TATCT6CAAATGAACAGCCTGC6TGCCGAGGATACC6C6GTATATTACTGT6CGAAACA6TCGCTGACGG6GTATAGTA GGTCTTTTGACTACTG6GGTCAG6GAACCCTG6TCACCGTCTCGAGC (SEQ ID NO： 721) BMS3h-145 GAGGTGCAGCTGTTGGAGTCTGGGG6AGGCTT66TACAGCCT6GGGG6TCCCT6CGTCTCTCCTGT6CAGCCTCC66AT TCACCTTTTC6CAGAATCCGAT6TCGTGGGTCC6CCAC6CTCCAGGGAAGGGTCTAGAGTG66TCTCAACGATTCCTGC GAATGGTCGTCCTACATCCTACGCA6ACTCCGTGAAGGGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCG6TATATTACTGTGCGAAATATA6TCAGCAGCC66GTCGTC GGTTTGACTACTGGGGTCAGGGAACCCTGGTCACC6TCTCGA6C (SEQ ID NO; 722) BMS3h-146 GAGGTGCAGCTGTTGGAG 丁 CTGGGGGAGGCrTGGTACAGCCTGGGqGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGCTAATTATCATATGACGTGGGTCCGCCAGGCTCCAG6GAA6GGTCTA6AGT6GGTCTCATCGATTCCTGA TA6T6GTAAGCAGACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTACAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGTAGGATTCCGTCTCTTCTn TTGACTACT6GGGTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 723) 100-
163920.doc 201245225 BMS3h-147 GAGGTGCA6CTGTT66AGTCTGG6GGA66CTT66TACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCaCCGGAT TCACCTTTGC6CAGTATCATAT6C6TTG6GTCC6CCA6GCTCCAG6GAAGGGTCTAGA6TG66TCTCAACGATTAATGA TATTGGTAGTAATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCCTGCCGAGGACACCGCGGTATAHACTGTGCGAAAGTTGGGGGGCGGGGGAGTTTTT CTTTT6ACTACTGGGGTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 724) BMS3h-148 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGC 下 TGGTACAGCCTGGGGGGTCCCTGCGTCTCKCTGTGCAGCCTCCGGAT TCACCTTTTCTTC6TAT6ATATGAA6TGG6TCCGCCAGGCTCCAG66AAG6GTCTAGAGT6GGTCTCAACGATTAGTGC GTCTGGTGTGTTTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGAG6ACACC6CGGTATATTACT6TGCGAAAC66GA6CATGCGKTCAGCC6C CTTTT6ACTACT6G6GTCA6GGAACCCT66TCACC6TCTC6AGC (SEQ ID NO： 725) BMS3h-149 GAGGT6CAGCTGTTGGAGTCTGGG6GAGGCTTCGTACAGCCTGGG6GGTCCCTGC6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTAATGGTTATGCTATGAGTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAACTATTAATGC TAATGGTAAGTATACATACTACGCAGACTCC6TGAA66GCC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAAAGTTGACTCrTGCTTCTAATT ATTTT6ACTACT66GGTCA6GGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 726) ΒΜ53Η-15Θ
6AGGT6CAGCT6TTGGA6TCTGGGGGAG6CTT66TACAGCCTGG6GG6TCCCT6C6TCTCTCCT6TGCA6CCTCCG6AT TCACCTTTAT6GATTAT6ATATGAAGTGGGTCC6CCAGGCTCCAG6GAAGGGTCTA6AGTGGGTCTCAAGTATTACTGC GC 了 TGGTAAGAAGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCQCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6C6TGCCGA6GACACC6C6GTATATTACTGTGCGAAAGATA6T6TTAAGTATCCTCTTA ATCTTTTTGACTACTGGGGTCAGGGAACCCTGeTCACCOTCTCGAGC (SEQ ID NO： 727) BMSBh-151 GA6GTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACA6CCT6GGGGGTCCCTGCGTCTCTCCT<5TGCAGCCTCCGGAT TCACCTTTCCGCATTATACGATGGCGTGGGTCCGCCA66CTCCA6G6AA6G6TCT6GA6T6GGTCTCATCTATTCAGTC GCCTGGTT6GCG6ACATACTACGCA6ACTCCGTQAA6GGCCG6TTCACCATCTCCC6CGACAATTCCAAGMCACGCTG TATCTGCAAATGAACAGCCTGCGTGCC6AGGATACCGCGGTATATTACT6T6CGAAATATGGG6ATGGTCTTCCTTT6A CTTTTGACTACTGGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO; 728) BMS3h-167 GAGGTGCAGCTGTTGGAGTCTGGGGCAG6CTTGGTACAGCCTGGGGG6TCCCTGC<3TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTACTGGTACGCCGATGTCTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCACGTATTGGGGA TGAGGGTCAGGAGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGMCACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGAGGACACC6CGGTATATTACTGT6CGAAAG6GGTGACTCCGGATTT6ACTT TTGACTACTGGGGTCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 729) BMS3h-168 GAGGTGCAGCTGTTGGA6TCTGGGGGA66CTTGGTACAGCCTG6GGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTAGTAGTAGTTCGATGTCITGGGTCCGCCAGGCTCCAGGGAAGGOTCTAGAGTGGGTCTCAGCGATTGGGTC 了 GATGGTCCGAGTACATACTACGCACiACTCCGTGAAGGGCCGGT 丁 CACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGCGTATTCCTACTCTTCATT TTGACTACT6GGGTCAGGGAACCCTGC3TCACCGTCTC6AGC (SEQ ID NO： 73Θ) 101- 163920.doc 201245225 BMS3h-169 GAGGT6CAGCTGTTGGAGTCTG6GG6AGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTAATCCTGGTGAGATGAC6TGGGTCCGCCAG6CTCCAGGGAAGGGTCTAGAGT6GGTCTCAAGTATTGATGG 6TCTGGTTCTTCGACATACTACGCAGACTCCGT6AAGGGCCGGTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGATGACACCGCGGTATATTACTGTGCGAAAGGGCGTATTCCTACTCHCAT 丁 TTGACTACT666GTCAGGGAACCCT6GTCACCGTCTCGA6C (SEQ ID NO： 731) BMS3h-170 6AGGTGCAGCT6TT66AGTCTGGGGGAGGCTTGGTACAGCCT6GGG6GTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTCCTGAGTCTATGATGGGGTGGOTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCGATTGGGTA 丁 CCTG6TGCTACTACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCC(3CGACAATTCCAAGAACAC(5CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGGTGGTAGTCGGGATGATAATT TTGACTACTGGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 732) BMS3h-171 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGOTCCCTGCGCCTCTCCTGTGCAGCCTCCGGAT TCACCTTTG6TCAGCATAGTAT6CATT6GGTCCGCCAGGCTCCAGGGAAGGGTCTAGA6TG6GTCTCAAGTATTAGTGT TCCG66TCCGMGACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAA6MCACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAG6ACACC6CGGTATATTACT6T6C6AAAA6TCTTAGG6ATTT6C6TCC6G GTGATAGTAAGAGTTTTGACTACTGGGGTCAGGGAACCCT<3GTCACCGTCTCGAGC (SEQ ID NO: 733> BMS3h-197 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGGTTCTGCT6CTATGGATTGGGTCCGCCA66CTCCAGGGAA6GGTCTAGAGTG6GTCTCATCTATTAATGA TATGGGTTCTAATACATACTAC6CAGACTCCG 丁 GAAGGGCCGOTTCACCATaCCCGCGACA/VTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGTGCCGAGGACACCGC6GTATATTACTGT6CGAAACA6G6T66TCGTTTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 734) BMSBh-199 GAGGTGCAGCTGTTG6AGTCTG6GGGA6GCTTGGTACAGCCT6G6G6GTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGGTTATGATAGGATGGCTTGG6TCC6CCA6GCTCCA6GGAA6G6TCTA6A6TG66TCTCATC6ATTGATGG TCCTGGTGGGGCTACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGAGGACACCGCGGTATATTACT6TGCeGAAGG6AGGAGGGTTCCTGATTTT6 ACTACTGGGGTCAGG6AACCCT6GTCACCGTCTCGAGC (SEQ ID NO: 7B5) BMS3h-260 GA6GTGCAGCTGTTG6AGTCTGGGGGAGGCTTGGTACA6CCTGGG6GGTCCCTGCGTCTCTCCT6T6CA6CCTCCG6AT TCACCTTTGCTGAG 下 ATGAGAT6ACTTGG6TCWCCAGGCTCCAGGGAAGGCTCTAGA6TGGCTCTCAAGGATTGATCC GTTTGGTTCTGA6ACATACTACGCAGACTCC6TGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGGAAGGTGTGGTTCCTGATTTGAATT TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 736) BMS3h-201 GAGGT6CAGCT6TTGGA6TCTGGGGGA6GCTTGGTACAGCCTGGG6GGTCCCT6C6TCTCTCCT6TGCAGCCTCCG6AT TCACCTTT6ATAAGTAT6TTATGGGGT6GGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGT6GGTCTCAACTATTGGTAG TTATGGTGGGGCTACATACTACGCAGACTCC6TGAAGGGCC66TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCG 丁 GCCGAGGACACCGCGGTATATTACTGTGCGAAAAGGCTTACTCTTAGTGCGACTA AGTTT6ACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 737) 102-
163920.doc 201245225 BMS3h-203 GAGGTGCA6CTGTTG6AGTCTGGG6G^G6CTT6GTACA6CCTGGGG66TCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGGATTATGT6ATG66TTGGGTCCGCCAGGCTCCAGGGAA6S6TCTAGAGTGGGTCTCAACTATT6CGCA TCG6GGTGATATTACATACTACGCA6aCTCCGTGAA6GGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGC(3TGCC6AGGACACCGCGGTATATTACTGTGCGAAACGTA66CGTCTTA(5TGATTATC GGTTTGACTACTGGGGTCAG6GAACCCTGGTCACCGTCTC6AGC (SEQ ID MO： 738) BMS3H-204 6AG6T6CAGCTGTTG6AGTCTGGGG6aGGCTT6GTACA6CCTG6GGGGTCCCT6C<3TCTCTCCT6T6CAGCCTCCG6AT TCACCTTTG66CA6TTTGATAT6TATTGGGTCCGCCAG(5CTCCAG6GAAGGGTCTAGAGTGGGTCTCA6CGATTAGTCC GGCTGGTACTGGTACATACTACGCAGiVCTCCGTGAAGGGCCGGinCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAAT6AACAGCCTaC6T6CCGAGGACACCGC6GTATATTACTGTGC<5AAAGCGGGG6ATCGGTCTAGTCTTT TTGACTACAGGGGTCAGGGAACCC了GSTCACCGTCTCGAGC <SEQ ID NO: 739) BMSBh-205 GAGCTGCAGCTGTTGGACTCTG咖GAGGCTTGGTACAGCCTGGOTGGTCCCTGC6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTAAGGATACGGGTATGACGrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAAGTATTTCTAG TTATGGTCGTGATACATACTACGCA6ACTCC6TGAAGGGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACA6CCTGCGTGCC6AG6AC6CC6CGGTATATTACTGTGCGAAATTGAATGCGGCGCT6GGTTTTG ACTACT6GG6TCA6GGAACCCTG6TCACC6TCTC6AGC (SEQ ID NO： 740) BMS3h-206
6AGGT6CAGCT6TTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGG(3GTCCCT6C6TCTCTCCT6T6CAGCCTCCGGAT TCACCTTT6GTCCGTATCCGATGAGTrGG6TCC6CCAGGCTCCAGG6AAG6GTCTA6AGTGGGTCTCAGGTATTAATGC GCCGGGTACGAGGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGA66ACACCGCGGTATATTACT6TGC6CAACA6AT6TCTAGTG6G6TTTTTG ACTACTGGGGTCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 741> BMS3h-207 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGCTCCCTCCCTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTTCGAATCAG6ATAT6ACTT66GTCCGCCAGGCTCCA6GGAAGGGTCTAGA6TGGGTCTCAA6TATTGATA6 TTCTGGTCAGCTTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCrG TATCTGCAAATGAACA6CCTGCGTGCCGAGGACACCGCGGTATATTACT6TGCGAAA6TTAAGTCTCTTGCGC66TTT6 ACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 742) BMS3h-208 GAGGTGCA6CTGTT6GA6TCTGGGGGA6GCTT6GTACAGCCTG6G6G6TCCCTGCGTCTCTCCTGC6CAGCCTCCG6AT TCACCTTTCCTGA6TCTGATATGAA6T66GTCC6CCAG6CTCCAGG6AAG66TCTA6A6TGG6TCTCAAGTATTAGTCC GAATGGTTGGGATACATACTAC6CA6ACTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACT6TGCGAAACCGGCTCAGGTTCTGTTTGACT ACTGGGGTCA66GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 743) BMS3h-209 GAG6T6CA6CTGTTGGAGTCTG6GGGAGGCTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCC6GAT TCACCTTT6AGCA6TATGTGATG6GTTGGGTCCGCCAGGCTCCAGGGAAGG6TCTAGAGTGGGTCTCAACGATTG6TAC GTCGGGTAAGTATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACMTTCCAAGAACAWCTG TATCT6CAAAT6AACAGCCTGCGTGCC6AGGACACCGC6GTATATTACTGT6C6CAAC6TA6GTCTCTGACTCGGGTTC ATTTT6ACTACTGGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 744) 103· 163920.doc 201245225 BMS3h-210 GAG6TGCA6CT6TTGGA6TCTGGGGGAGGCTTGGTACAGCCTGGGGG6TCCCTGC6TaCTCCTGTGCAGCCTCCGGAT TCACCTTTG6TGT6GA6CATATGAGTTG6GTCC6CCA6GCTCCAGGGAA6G6TCTAGAGTG6GTCTCAGC6ATTACGG6 TGATGGT6ATCGTACATACTACGCAGACTCCGTGAA6G6CCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGC6T6CCGA66ACACC6CGGTATATTACT6TGCGAAAACGGTTTCGTG6AAT66TCGTT HGACTACTGGGGTCAGGGAACCCT6GTCACCGTCTCGAGC <SEQ ID NO: 74S) BMS3h-211 GAG6T6CAGCTGTTGGAGTCTGGGGGAG6CTT66TACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTT6CGTG6TATAATATGG6TTGG6TCC6CCAGGCTCCA666AAGGGTCTGGA6TG66TCTCAAGGATTGCTCC GTCTGGTATTATTACATACTACGCAGACTCCGT6AA6G6CCGGTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCC6AGGACACCGCGGTATATTACTGT(k：GAAAGGGTTGCGTGGTAAGTTTCAC 丁 ACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 746) BMSBh-212 6AG6T6CA6CTGTTG6AGTCTG6G6GAGGCTTGOTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCG6AT TCACCHmGA/VmTGAGATGAGGTGGCTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTTCTTC G6CT66TACTGATACATACTAC6CAGACTCC6T6AA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6CCGAGGACACCGC66TATATTACTGTGCGAAACA6TCGCTTAATTTTGACTACT 66GGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 747) BMS3h-213 GAGGTGCA6CTGTTGGA6TCTGGGGGA6GCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6T6TAGCCTCCGGAT TCACCTTTGATGAGGAGCCGATGACTTGGGTCCGCCAGGCTCCAGGGAAGG6TCTAGAGTG6GTCTCAATTATTGATCC GGGTGGTGG6GCGACATACTACGCAGACTCC6TGMG6GCCG6TTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCiGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATAHACTGTGCGAAATCTAATAGTATGTTTGACTACT GGG6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 748) BMS3H-214 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTCGGGGGTCCCTGCGTCTCTCCTGTGCAGCC 了 CCGGAT TCACCTTTTCT6CGTATCCTATGCATTGGGTCC6CCAGGCTCCA6G6AAGGGTCTAGAGT666TCTCATCTATTGCTTC TTCGGGTATTACGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATaGCAAATGMCAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAATTTACTCGGCTGCATTnCCTG CGCA6TTTGACTACTGGGGTCA6GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 749) BMS3M-215 GAGGTGCAGCTGHGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCirGTGCAGCCTCCGGAT TCACCTTT6CTGATTATGCGATGG6TT6GGTCCGCCAGGCTCCAGG6AAG6GTCTA6A6TG6GTCTCAAGGATTTCTCC 了 GAGGGTTCTAG6ACATACTACGCAGACTCC6TGAAGG<3C：CGGHCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CC6A6GACACCGCGGTATATTACTGTGCGAAATTGC6GCCGTATGCGTCGAAGT TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 75Θ) BMS3h-230 GAGGTGCAGCTGTT6GAGTCT6G6GGAGGCTTG6TACAGCCTGGG6G6TCCCTGC6TCTaCCTGTGCAGCCTCC6GAT TCACCTTTA6GCCGTATGATATGGGTTG6GTCC6CCAGGCTCCA6G6AAG6GTCTAGAGTG6(；TCTCAAC6ATTTCTCA TCAGGGTAATCG6ACATACTACGCAGACTCC6T6AAGGGCC6GTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGACACCGCGGTATATTACTGTGC6AAA6TGTCTCATCATTTTGACTACT GGGGTCAGGGAACCaGGTCACCGTCTCGAGC (SEQ ID NO: 751) -104·
163920.doc 201245225 BMS3h-231 6AG6TGCAGCTGTTGGAGTCT66666A66CTTGGTACAGCCT6GGGGGTCCCT6C6TCTCTCCT6TGCA6CCTCCGGAT TCACCTTTTCTGC6TATAATATGT66V6G6CCCGCCAGGCTCCAGGGAA66GTTTAGAGTGGGTCTCATG6ATTAATTC GACTG6TTCTCGTACATACTAC6CA6yvCTCCGTGAAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCT6C6TGC<：GAGGATACCGCGGTATATTACT6T6CGAAAAATT6GCATC6GG6GAGGTTT6 ACTACTGG6GTCAGGGAACCCT6GTCACCGTCTC6AGC (SEQ ID NO： 752) BMS3h-232 GA66T6CAGCTGTTG6AGTCTGGGGG/\6GCTTGGTACAGCCTeG6GGGTCCCTGCGTCTCTCCTGT6CAGCCTCC6GAT TCACCTTTGATA66TATCGGATGGG6rGGGTCC6CCA6GCTCCAGG6AA6GGTCTAGAGTG6GTCTCAACGATTAATCG 6CTGG6TCAGAGTACATACTACGCAG/<CTCC6T6AAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCaGCGT6C(：GAG6ACACC6CG6TATATTACTGTGCGAAAGT6AAGAA6CATAAGTTTGACT ACTGG66TCAGG6AACCCTGGTCACC(ITCTC6AGC (SEQ ID NO: 75B) BMS3h-233 GAGGTGCAGCTGTTGGAGTCTGGGGG/kGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACaTTGCGCATTATAATATGCGGTGGGTCCGCCAGGC： 了 CCAGGGAAGGGTCTAGAGTGGGTCTCAACGATTACGM 6ACTGGTTTTCGTACATACTACGCAGACTCCGTGAAGGGCC6GTTCACCATCTCCC6TGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGC(：GAGGACACCGCG6TATATTACT6TGCGAAAGC6GGGCAGTTTGATTTTGACT ACTGGGGTCAGGGAACCCTGGTCACCC.TCTC6AGC (SEQ ID NO: 754) BMS3h-234
GAGGTGCAGCTGTTGGAGTaGGGGG/iGGCTTAGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTTATCCTTATAGTATGCATTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCAACTATTGATGG TAGTGGTATGTTTACATACTACGCAG/tCTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCG 丁 GCCGAGGACACCGCGGTATAHACTGTGCGGAAGATTCTCTGAAGGaTCmTC； ACTACTGGGGTCAGG6AACCCTGGTO.CCGTCTCGAGC (SEQ ID NO： 755) BMSBh-235 GAGGTGCAGCTGTTGGAGTCTGGGGG/.GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCCGCTTTATGGGAT6TG616GGTCCGCCAGGCTCCAGGGAA6GGTCTAGAGTG66TCTCATATATTGGGCC TTATGGTCATACTACATACTACGCAG；,CTCCGTGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCT6 TATXTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAAAGCGGAAGAAGAAGmGAC 丁 ACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC <SEQ ID NO: 756〉 BMS3h-236 GAGGTGCAGCTGTTGGAGTCT6G6GG»fiGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCG6AT TCACCHTCCTAGCTATCGGATCAGHG 從 TCCGC ㈤ GCTCCAGGGMaCTCTAGACTGGGTCTCAACTAHACTC^ GTATGGTGCTCATACATACTACGCA6iSCTCC6TGAAGGGCCG6TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCT6C6TGCC6A6GACACCGCG6TATATTACT6TGC6AAATATGGTAAOTGGTATTTT6ACT ACTGGGGTCAGGGAACCCTGGKACCGTCTCGAGC (SEQ ID NO; 7S7) BMS3H-237 GAG6TGCAGCTGTTGGAGTCTGG6GG^.GGCTTG6TACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTAAT6AGTATGCGATGAGG1GGGTCCGCCAGGCTCCA6G6AAGGGTCTAGA6TGGGTCTCAACGATT6ATCG TCT6GGTCTTCATACATACTACGCAG/»CTCC6T6AAG66CCG6TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAAGTGGGCCTTTTACGTTTGACT ACTGGGGTCAGGGAACCCTGGTCACCCTCTCGAGC <SEQ ID NO: 758> •105· 163920.doc 201245225 BMS3h-238 GAG6T6CAGCT6TTG6A6TCT6GGGGAGGCTTG6TACAGCCT6GGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCC6GAT TCACCTTT6AGCGGTATAATATGCGTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGT6G<3TCTCAACGATT6ATCG 6CTGGGTCTTGCTACATACTACGCAGACTCC6TGAAGGGCCG6TTCACCATCTCCC6C6ACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCT6CGTGCC6A6GACACC6CGGTATATTACTGTGCGAAA6CG6GTTC6TG6TCTTTTGACT ACTGGGGTCA6G6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 759) BMS3h-239 6AGGTGCAGCTGTTGGAGTCTGGGGGA66CTTGGTACAGCCTGG6G6GTCCCTGCGTCTCTCCTGT6CA6CCTCCGGAT TCACCTTTGGTATTTAT6ATATGAAGTGGGTCCGCCA6GCTCCAGGGAAGGGTCTA6AGTGG6TCTCAACGATTTCGTC GTCGG6TACTCATACATACTACGCAGACTCCGTGAAGG6CCGGTTCACCATCTCCCGC6ACAATTCCAA6MCACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGA6GACACCGC6GTATATTACTGT6CGAAATATCCTCA6CCTTATCCTTTT6 ACTACTGGG6TCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 76Θ) BMS3h-240 GAGGTGCAGCTATTCGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC 了 CCTGTGCAGCCTCCG6AT TCACCTTTT6G6TGTATGATATGC6TTGG6TCCGCCAGGCTCCA6GGAAG6GTCTA6AGTGGGTCTCAAC6ATTTCTGC 6ACTG6T6TGCATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCT6 TATCTGCAAAT6AACAGCCTGCG 丁 GCCGACSGACACCGCGGTATATTACTGTGCGAAATATCCGCCTGCTGCTCGGTrTG ACTACTGGGGTCA6GGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO: 761) BMS3h-241 GA6GTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCT6666GGTCCCTGCGTCTCTCCTGTGCA6CCTCCG6AT TCACCTTTTCGACTTATGATAT6ATTTGGGTCC6CCA6GCTCCAG6GAAGGGTCTAGA6TGG6TCTCA6CTATTTCTCC TAATGGTACTGGTACATACTAC6CAGACTCCGT6AAGG6CC6GTTCACCATCTCCC6C6ACAAmCAA6AACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGACACCGCG6TATATTACTGTGC6AAACCTCCGCAGGTGAATACTGAGT TTGACTACCGGGGTCAGG6AACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 762) BMS3h-243 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGOTACAGCCTGGGGGCTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACaTTGAGAA66AGGATATG6G6TGGGTCC<5CCAGGCTCCAG6GAAGGGTCTA6AGT6GGTCTCACATATTTCGCC GAAT6GTTATGC6ACATACTACGCAGACTCC6T6AAGGGCC6GTTCACCATaCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCCGAG6ACACCGCGGTATATTACTGT6CGAAAAGTTGGTCTA6TTTT6AaACT GGGGTCAGGGAACCCT6GTCACC6TCTC6A6C (SEQ ID NO： 763) BMS3h-244 GAGGTGCA6CT6TTGGAGTCTG6GG6A66CTT6GTACAGCCT6GGGGGTCCCT6CGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTAGTGCTACTCC6ATGGAGTGGGCCCGCCA66CTCCAGG6AAGGGTCTA6AGTGG6TCTCAACTATTTCT6A GAGTGGTTATA6TACATACTACGCAGACTCCGTGAAGGGCC66TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGTGCC6AGGACACC6C6GTATATTACT6TGCGAAAT66AAHC6ACTACTGGTTTTG ACTACTGG6GTCA6GGAACCCT6GTCACC6TCTC6AGC (SEQ ID NO： 764) BMS3h-245 GAGGTGCAGCTGTTGGAGTCTGG6GGA66CTT6GTACAGCCTGGGGGGTCCCT6C6TCTCTCCT6TGCAGCCTCCG6AT TCACCTTTAATACGGTGGATATeGAGTGGOTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAAGTATTAGTCC GAATG6TTGG6ATACATACTACGCA6ACTCCGT6AAG66CCGGTTCACCATaCCCGCGACAATTCCM6AACACGCTG TATCT6CAAAT6AACAGCCTGCGT6CC6AG6ACACCGCG6TATATTACTGTGCGGAAGCTCCGCATCGGGCGTTT6ACT ACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 765) 106·
163920.doc 201245225 BMS3h-246 6AG6TGCAGCTGTTGGA6TCTGGGGGiG6GCTTGGTACAGCCT6GGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTTGAGGATAAGGA6ATGACnTG6GTCCGCCAGGaCCA66GAA6GGTCTAGAGTGGGTCTCACGGATT6ATGC TTTGGGT6ATTCTACATACTACGCACACTCCGTGAAGGGCCG6TTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGACACCGCGGTATATTACT6TGCGGAA6GGATGGTTCCTCGTCTGAA6T TTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: BMS3h-247 GA6GTGCA6CTGTTG6A6TCT6G6GGA6GCTT6GTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCA6CCTCCGGAT TCACCTTTAGT6ATCATTC6ATGAT6TGGGTCCGCCAGGCTCCA6GGAAGGGTCTAGAGT6GOTCTCAGATATTGA6CC GCATGGTGTTCATACATACTACGCAGACTCCGTGAAG6GCC6GTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGAGGACACC6CG6TATATTACTGTGCGAATCCTACTTTTGACTAaGG66TC AGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 767) BMS3h-248 GA6GTGCAGCTGTTGGAGTCTG6GGG\GGCTTGGTACAGCCT6GGGeGTCCCTGCGTCTCTCCT6TGCAGCCTCC66AT TCACCTTTTCGCCGCATAaATGCATrGGGTCC6CCAGGCTCCA6G6AA6G6TCTAGA6TGG6TCTCAG6TATTGGTCC GGAT6GTACTACTACATACTACGCAG\CTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGACACCGC6(5TATATTACTGTGC6AAACGTTC6TATA6TTGGGATC6TG GGTGGACGTTTGACTACTG6G6TCAGGGAACCCT6GTCACC6TCTC6AGC (SEQ ID NO: 768) BMS3h-249
GAGGTGCA6CT6TTGGAGTCTGGGGGAGGCTTGGTACAGCCT6GGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTmATGCTTCGGATATGAAGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAAGTATTAGTCC GAAT6GTTGGGATACATACTACGCA6ACTCCGTGAAGG6CC6GTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGT6C<：GAGGACACCGCGGTATATTACT6TGCGAAAGCTGAnATACTTATCATTCTr TTGACTACTGGGGTCAGGGGACCCTG(iTCACCGTCTCGAGC (SEQ ID NO： 769). BMS3h-259
GAGGTGCAGCTGTTGGAGTCTGGG66AGGCTTGGTACAGCCTGGGGG6TCCCTGCGTCTCTCCTGTGCAGCaCC66AT
TCACCTTTGCGCATTATAATATGCGGTGGGTCCGCCAGGCTCCAG6GAAGGGTCTAGAGT6GGTCTCAAC6ATTACGAA GACT6GTTTTCGTACATACTACGCA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGTGACAATTCCAAGAACACGCT6 tatctgcaaatgaacagcctgcgtgccgaggacaccgcggtatattactgtgcgaaagcggggcagtttgattttgact ACTGGGGTCAGGGAACCCTGCTCACCeiTCTCGAGC (SEQ ID NO： 77Θ) BMS3h-251 6AGGTGCAGCTGTTGGAGTCTG66G6/SGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCCG6AT irCACCTTTTCGCATTATCATATGGGTTGGGCCCGCCAGiSacCAGGGAAGGGTCTAGAGTGGGTCTCAGTTATTGGGCC GAG6GGTATTTCTACATACTAC6CAGACTCCGTGM6GGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAATCGCCTTCGCGTCATAGGTTTG AaACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 771) BMS3h-252 GAG6TGCAGCT6TTG6AGTCT6G6GGAG6CTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT 丁 CACCmAATGAGTATGCGATGAGGTGGGTCCCSCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTaCAACGATTGATCG TCT6G6TCTTCATACATACTACGCAGACTCCGTGAASG6CC6GTTCACCATCTCCC6C6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGA66ACACCGCGGTATATTACTGTGCGAAAAGTGGGCCTTTTACGTTTGACT ACTGGGGTCAGGGAACCCTGGTCACCGrCTCGAGC (SEQ ID NO: 772) 107· 163920.doc 201245225 BMS3h-253 GAG6TGCAGCT6TTGGAGTCT6GG6GA6GCTT6<3TACAGCCT6GGGG6TCCCT<3CGTCTCTCCTGT6CAGCCTCC6GAT TCACCTTTG6TAATTATA6TATGAAGT66GCCC6CCA6GCTCCA66GAAGGOTCTAGAGT66GTCTCAACTATTACTCC TGATGGTTGGTATACATACTACGCAGACTCC6TGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAA6AACAC6CTG TATCT6CAAAT6AACA6CCTGCGTGCC6AGGACACCGCGGTATATTACT6TGC6AAAGTGGGGGATGCT6TTTGGGGGT 66ATTGGT6GGTTTGACTACT6GGGTCA66GAACCCT6GTCACCGTCTCGA6C (SEQ ID MO: 773) BMS3h-254 GA6GTGCAGCTGTT66AGTCTG66G6AGGCTTGGTACA6CCT<5G(5GGGTCCCT6CGTCTCTCCTGTGCAGCCTCC66AT TCACCTTT6GGGATTATGGTAT6AA6TGG6TCCGCCA6GCTCCAGGGAAG6GTCTAGAGT6GGTCTCAGCTATTAC6TC TAATGGT6ATTTTACATAaACGCAGACTCC6T6AAGGGCC66TTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGT6CCGAGGACACC6CGGTATATTACTGTGC6AAATCTTTGTATAAGTTTGACTACT 6GG6TCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 774) BMS3H-255 6AGGTGCAGCTGTTG6AGTCTGGGGGA66CTT66TACA6CCTCGGGGGTCCCTGCGTCTCTCCT6TGCA6GCTCCGGAT TCACCTTTCCTACTTATAA6ATGG6GTGGGTCCGCCAGGCTCCAGG6AAGGOTCTA6A6T6G6TCTCATTTATTGATTA TTGGGGTTGGC66ACATACTAC6CA6ACTCCGT6AAGG6CCG6TTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAeCCTGCGTGCC6A6GACACC6CG6TATATTACTGT6CGAAAA6TCC6TATTCTT6GACTCAT6 ATAGTCCTCATTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 77S) BMS3h-256 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTnA6GCCTTATACGATGTGTTG6GCCCGCCAG6CTCCAGGGAAGGGTCTAGAGTGGGTCTCATGTATTAGTGA TGCTGGTTCTTTTACATACTACGCA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGTGCCGA6GATACCGCG6TATATTACTGTGC6AAAAG6ATGTCTTCTTTT6ACTACT 6GG6TCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 776) BMSBh-257 GA66T6CAGCTGTTG6AGTCTGG6GGAGGCTTG6TACAGCCTG6GGG6TCCCTGCGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTTCAGAATTATCAGATGGCTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAACTATTAGTGG GACTGGTAAGAATACATACTACGCAGACTCCGT6AAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCC6AGGACACCGCGGTATATTACT6TGC6AAAACTCCTCA6AATTATTTTAGTG 了GCGTCGGTTTGACTACTGGGGTCA66GAACCCTGGTCACCGTCTCGAGC <SEQ ID NO: 777> BMS3h-258 GAGGTGCAGCTGTTGGA6TCTGGGG6A6GCrT6GTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGGGGCGTATACTATGGGGT6G6TCC6CCAGGCTCCAGG6AAGGGTCTAGAGTGGGTCTCAAA6ATTTC6AC GTCTGGT6GGCAGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACAC6CT6 TATCTGCAAATGMCAGCCT6CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACCTTTGAATTGGT6G6CGTTTG ACTACT6G6GTCAGG6AACCCTGGTCACC6TCTC6AGC (SEQ ID NO: 778) BMS3h-272 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTHAATGCGTATCCTATGAGTGG6TCCGCCAGGCTCC：AGGGAAGGGTCTAGAGTGGGTCrCACG6ATT6ATGG TTATGGTC6GCATACATACTACGCAGACTCC6TGAAGGGCC66TTCACCATCTCCC6CGACAATTCCAA6AACAC6CTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGACACCGC6GTATATTACTGTGCGAAAGG6ATTATTCCTAATTTTGACT ACT6GGGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO; 779) • 108 ·
163920.doc 201245225
BMS3h-27B GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTT6GTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCA6CCTCCGGAT TCACCTTTGGGGCGGTTGATATGACGTG6GTCCGCCAGGCTCCAGG6AAG6GTCTAGAGTGGGTCTCA6CGATTTCGCC TAGTGGTTCTGCTACATACTACGCASACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATtCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGGGCGTGTGCCGGATCTTGGTT TTGACTACTGGGGTCA6GGAACCCTGGTCACC6TCTCGA6C (SEQ ID NO: 780) BMS3h-274 GAG6T6CA6CTGTTGGAGTCTGGGGSAGGCTTGGTACAGCCTGGG666TCCCTGCGTCTCTCCT6TGCAGCCTCC6GAT TCACCTTTGATAGTTATGCGATGGGSTGGGCCCGCCAGGCTCCA6GGAAGG6TCTAGAGT6GGTCTCAGCTATTGGG6C TAAGGGTTTGTCTACATACTACGCASACTCCGTGAA6GGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAAT6AACA6CCT6CGTGCCGAGGACACCGCG6TATATTACTGTGCGAAAGCGGCTAGG6GTAA6TTTGACT ACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 781) BMS3h-275 GAGGTGCAGCTGTTGGAGTCTGGGG'SAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCaCCGGAT TCACCTTTACTC66TATCAGATG6GTTGGGTCCGCCAGGCTCCAGG6AA6GGTCTAGAGTG66TCTCA6TTATTAATGT TTGGGGTTCGAGTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG 丁 AT〔TGCAAATGAACAGCCTGCGTGaGAGGACACCGCGGTATAHACTGTGCGAAAATGTCTC3<3GAAGTTTGCCTAC 丁 GGGGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO； 782) BMS3h-276
GAGGT6CAGCTGTTGGAGTCTGGGG'3AG6CTTGGTACAGCCTGGGGGGTCCCTGCGTCTTTCCTGTGCA6CCTCCGGAT TCACCTTTGGGAATTATAGTATGAPnGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTC： 丁 CAACGATTATTCC TGCTGGTACGTCTACATACTACGCAiSACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGi：CGAGGACACCGCG6TATATTACTGTGCGAAACCGTCGATTAGGTT6TTTGACT ACTGGG6TCAGGGAACCCTGGTCAC'：GTCTCGAGC (SEQ ID NO： 783) BMS3h-279 GAGGTGCA6CTGTT6GAGTCTGGGG'jAGGCTTGGTACAGCCTGGG6GGTCCCT6C6TCTCTCCT6T6CAGCCTCCGGAT TCACCTTTGGTGCGTATGATATG6G«3TGGGTCCGCCAGGCTCCAG6GAAGGGTCTAGAGTGGGTCTCATGGATrTCTCC GAATOGHATGATACATACTACGCAGACTCCGTGMGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGT6i：CGAGGACACCGCG6TATATTACT6T6CGAAA6GGGGTGTGAA6TTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC <SEQ ID NO: 784) BMS3H-282 GAGGTGCAGCTGTTGGAGTCT6GG©3AGGCTTG6TACAGCCT66G6GGTCCCTGCGTCTCTCCT6TGCAGCCTCC6GAT 丁 CACGnfTGTTTGGTATGAGATGGCrTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAACGATTCAGGC TGAT6GT6AGCA6ACATACTACGCA<3ACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACA6CCT6C6TGCC6AGGATACCGC6GTATATTACTGTGC6AAA6CTTC6TATGCTCTTGTGTATC CTCCTGAGGA6TTTGACTACT6G6GTCAGGGAACCCTG6TCACCGTCTCGA6C (SEQ ID NO: 785) BMS3h-287 GA6GTGCA6CTGTTG6A6TCTGG6GGAGGCTTG6TACAGCCT6GGG6GTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTACGAATTATAGGAT6TCTTGGGTCCGCCAGGCTCCAGG6AAGGGTCTA6A6TGGGTCTCAGCTATTGAT6A TCTGGGTGTGTCGACATACTACGCA<3ACTCC6T6AAG6GCCGGTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6：CGAGGACACCGCG6TATATTACTGTGCGAAATG6A6GCTTMGAATAGTCAGC CGACGGATTTTGACTACT6GG6TCA3GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 786) 109- 163920.doc 201245225 BMS3h-292 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCrrTGATCAGGCTCATATGTGGTGGGTCCGCCAGGaCCAGGGAAGGGTCTAGAGTGGGTCTCATTTATTAATCC TTCGGGTTAHATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CC6AGGACACCGCGGTATATTACTGTGCGAAACCTTCGCnAGTCCGTCTTCTT TTGACTACTGGGGTCAG66AACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 787) BMS3h-293 GAG6TGCAGCTGTTGGAGTCTG6GGGA6GCTTGGTACAGCCTGGGG6GTCCCT6CGTCTaCCTGTGCAGCCTCCGGAT TCACCTTT6A6ACTG6TCA6ATGG6TTGGGCCC6CCAG6CTCCA666AA6GGTCTA6A6TG66TCTCAAATATT6ATGG GTCTGGTACGTATACATACTACGCAGAC 了 CCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6CCGA66ACACCGC66TATATTACTGTGCGAAAAGTACGCAGAATTATC66TTTG ACTACT666GTCA666AACCCT66TCACC6TCTCGAGC (SEQ ID NO: 788) BMS3H-296 GAGGTGCA6CTGTTG6AGTCT6GG66AG6CTT6GTACA6CCTGGG6GGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6GT6CTTATCCGAT6TATT6GGTCC6CCAGGCTCCAGGGAAGGGTCTA6AGT6GGTCTCATCTATTCATAA G6AT6GTAGGATTACATACTACGCA6ACTCC6TGAAGG6CC66nGACCATCTCCC6CGACAATTCCAAGAACAC6CT6 TATCT6CAAAT6AACAGCCTGCOT6CC6AG6ACACCGCGGTATATTACT6TGCGAAACAG66TAC6CCGGTTGAT6GGT TT6ACTACTGGGGTCA6G6AACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 789) BMS3h-297 GAG6TGCAGCTGTT66AGTCT66GGGAG6CTTGGTACAGCCT6GGGG6TCCCTGC6TCTCTCCT6T6CAGCCTCCGGAT TCACCTTTCCTGATGA66GTATGACGTGGGTCCGCCAGGCTCCAGGGAA666TCTAGAGTGG6TCTCAACGATTGAGAC TGGT6GTACGGTGACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAAT6AACAGCCTGCGT6CC6AG6ACACCGCG6TATATTACT6TGCGAAAATG6ATG6GTCTG6TACATG6C AGACGTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 790) BMS3h-298 GAGGT6CA6CT6TTG6A6TCTGGGGGAGGCTTG6TACAGCCT6GGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGATA6TCTGGGTATGGGTTGGGCCCGCCAG6CTCCA6GGAAG66TCTAeAGTGG6TCTCATATATTCGG6C TGAGGGT6CTTATACATACTACGCAGACTCC6TGAAGGGCCG6TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCCGAGGATACC6CGGTATATTACT6TGCGAAATATCTTGCGGATTCTGACTACT GGCGTCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 791) BMS3H-299 GAGOTGCAGCTGTTGGAATCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTCCGTCTCTCCTGTCCAGCCTCCGGAT TCACCTTTA6T6AGTCGTATATG6AGTCGGTCCGCCAGGCTCCAGGGAAGGGTCTAGACTGGGTCTCAGGTATTGATCA TATTCGT6GTG6GACATACTACGCAGACTCCGT6AAG66CC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCCGAGGACACCGC6GTATATTACT6TGCGAAAGATGATG6TCGT66T6GGTCTA TGTTTGACTACTGGGGTCAGGGAACCaGGTCACCGTCTCGAGC (SEQ ID NO： 792) BMS3h-300 GAGGTGCA6CTGTTGGA6TCTGGG6GA6GCTTGGTACAGCCTG6G6GGTCCCTGCGTCTaCCTGTGCAGCCTCCGGAT TCACCnTTCT6GTGGGTATAT6T6GT666TCCGCCAGGCTCCAGG6AA6GGTCTAGAGTGGGTCTCAAGTATT6G6GC TA6T6GTGCGTATACATACTAC6CAGACTCC6TGAAGGGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGC6TGCCGAGGACACCGCG6TATATTACT6T6CGAAAACGG6GG6TAG6TTAGACTACT GGG6TCA6G6AACCCT6GTCACCGTCTC6AGC (SEQ ID NO： 793) •110·
163920.doc 201245225 BMSBh-301 GAGGTGCAGCT6TTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGG6GGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGATGAGGGGCATATGG6GTGGGTCCGCCAGGCTCCAG6GAAGGATCTAGAGTGGGTCTCATATATTGGGAG TCTGGGTTTGCATACATACTACGCAGACTCCGTGAAGG6CC66TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGA66ACACCGCGGTATATTACTGTGCGAAACGGGA6TTTAGTAATGGGGGGT TTGACTACTGGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 794) BMSBh-3G2' GAGGTGCAGCTGTTGGAGTCTGGGGGAG6CTTGGTACAGCCTG6G6GGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT 丁 CACCTTTAAGACTAGTCC 丁 ATGTAT 了 GGGTCCGCCAGGCTCCAGGGAAGGGTC 了 AGAGTGGGTCTCATCGAHGATCG GACTGGTGGGCATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACMTTCCAAGAACACeCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACAGGCTCTGCTTACTGATGCGA AGCGTTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 795) BMS3h-303 6AGGT6CAGCTGTTGGAGTCTGGGGG/\6GCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTGATGGTCGGGATATGGTTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTCC GAGTGGTCTGGATACATACTACGCAG/iCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG 了 ATC 了 GCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGGAACGTCCTCAGATGCTGOTTACTA AmTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 796) BMS3H-304
GAG6TGCAGCTGTTGGA6TCTGGG6GAG6CTT6GTACAGCCTGGGGG6TCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTT6GTAATGATCCGATGAGTTGGGTCC6CCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGGGATTGGTCG GGAGGGTGATTCTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCC6AG6ACACC6CG6TATATTACT6TGCGAAAGATTCTATGCGGCATCAGCCGT TTGACTACTGGG6TCA6GGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 797) BMS3h-305 GAGGTGCAGCTGTT6GA6TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCC6GAT 了 CACXTTTGATGAGACTTATATGAAGTGGGTCCGCCAGGCTCCAGiSGAAGGGTCTAGAGTGGG 了 CTCAGCG/UTGGGGC GTCGGGTGCTGATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTA 下 ATTACTGTGOSAAATTTACGCATCTGAATGCTCGCT TT6ACTACTG6GGTCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 798) BMS3h-306 6AG6T6CAGCT6TTGGAGTCTGGGGG/SGGCTT66TACA6CCT6G66GGTCCCTGCGTCTCTCCTGTGCAGCCTCC6GAT 了 CACCTTTGGGGGGTGGCCTATGGGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGOTATTGATAT TGATGGTGCTCC6ACATACTAC6CAGflCTCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATaGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGGAGGCGGGTTCTTGGTCTT TTGACTACTGG6GTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 799) BMS3H-307 6AGGTGCA6CTGTTG6AGTCTGGGGGysGGCTTGGTACA6CCT6G6GG6TCCCTGCGTCTCTCCT6T6CAGCCTCCG6AT TCACCTTTAGT6ATCAGGCGATGTGGT6GGCCC6CCAG6CTCCA6GGMGGGTCTAGA6TGGGTCTCATTTATTCAGGG TGAT6GT66TTTTACATACTAC6CAGiQ.CTCCGTGAAG6GCC66TTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACCTAGTAAGCCOTTTGACTACT 6GGGTCAGG6AACCCT6GTCACCGTCTCGA6C (SEQ ID NO： 800) -111- 163920.doc 201245225 BMSBh-308 6AGGTGCAGCTGTTGGA6TCTGGGGGA6GCTTGGTACAGCCTG6GGGGTCCCTGCGTCTCTCCTGTGCA6CCTCCGGAT TCACaTTGAGACT6GTCAGAT66GTT6GGCCCGCCA6GCTCCA<5G6AAGG<3TCTAGAGT6G6TCTCAAATATT6AT6G GTCTGGTACGTATACATACTACGCA6ACTCCGTGAAGG6CCGGTTCACCATCTCCC6CGACAATTCCAAGAACAC6CTG TATCT6CAAATGAACAGCCTGC6TGCC6AGGACACCGC6GTATATTACTGTGC6AAAGCGGTGCGGAATTTTGCTm6 ACTAaGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 801) BMS3h-309 6A6GTGCAGCTGTT66AGTCTGG6GGAGGCTTG6TACA6CCTGGGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTTAGTGG6CATGATAT6TCTT6GGTCCGCCAGGCTCCAGG6AAGGGTCTAGAGT6GGTCTCA6CTATTAGTCC TCAT6GTACGCATACATACTACGCA6ACTCCGTGAAGGGCCGGnCACCATCTCCCGCGACAATTCCAAGAACAC6CT6 TATCT6CAAATGAACAGCCT6C6TGCCGAGGACACCGCG6TATATTACTGTGCGAAAGGGATTAGGGGTTG6ATTGGTC AT6ATACGCA6CCTTTT6ACTACTG66GTCA66GAACCCTG6TCACCGTCTCGAGC (SEQ ID NO： 802) BMS3h-310 GA6GTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGG6TCCCTGC6TCTaCCTGTGCAGCCTCC66AT TCACCTTTGAGAGTAAGGATATGCTTTGGGTCCGCCAGGaCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTTCCTC GGATGGTACTCATACATACTACGCAGACTCC6TGAAGGGCC6GTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAMTGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGCAAGAGCTGGGTGGGTCTTGGCAGT TTGACTACTGGGGTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 803) BMS3h-311 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6CGGATC6TGATATGGTTTGGGTCCGCCAG6CTCCAGG6AAGGGTCTAGAGTGGGTCTCA6GTATT6G66C GTCGG6TACGTCTACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGC6TGCCGAG6ACGCC6CGGTATATTACTGTGCGAAAGGTC6GACGG6TCCTACTGATT TGTGGGATTTTGACTACTG6GGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 804) BMS3h-312 GAG6T6CAGCTGTTGGAGTCT6GG6GAGGCTT6GTACA6CCTGGGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCC6GAT 了 CACCTTTGATGATGAGAAGATGCTTTGC3GTCCGCCAGGaCCAGGGAAG66TCTAGAGTGGGTCTCAAGTATTAGTGT 6AGTGGTCTGCATACATACTACGCAGACTCCGTGAA6G6CCGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGAGGACACCGC6GTATATTACTGTGCGAAAGA6GAGGCGG6TTCTTG6TCTT TTGACTACT6G6GTCA6GGAACCCTGGTCACC6TCTCGA6C (SEQ ID NO： 805) BMS3h-313 6AGGTGCAGCT6TTGGA6TCC6GG66AG6CTTG6TACAGCCTGGGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTT6GGCAGGAGAGGAT6ATTTGGGTCC6CCAG6CTCCTGGGAAGG6TCTAGAGTGGGTCTCAGATATTTCGGC TTC6G6TGGGACTACATACTAC6CAGACTCCGT6AAGGGCC6GTTCACCATCTCCCGC6ACAATTCCAA6AACAC6CT6 TATCTGCAAATGAACA6CCTGCGTGCCGA6GACACC6C66TATATTACT6TGCGAAAeAGGAGGCGGGTTCTTGGTCTT TTGACTACTGG66TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 806) BMS3h-37-l GAGGTGCAGCTGTTGGA6TCTGGGGGAGGCTTGGTACAGCCTGGG666TCTCTGCGTCTCTCCT6TGCAGCCTCC6GAT TCACCTTTGAGTGGTATGAGATGCAGTGGGTCCGCCAGGCTCCAGGGAAGGOTCTAGAGTGGGTCTCAGCGATTTCTGG TGATG6TTATC6TACATACTACGCA6ACTCC6TGAAAG6CCG6TTCACOVTCTCCCGCGACAATTCCATGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCTTGGGTAmTGACTACA GGGGTCGGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 807) -112-
163920.doc 201245225 BMS3h-37-2 GAG6T6CAGCTGTTG6AGTCTGGGGGA'5GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGTGGTAT6AGATGCAGT<3G6TCCGCCGGGCTCCAGGGAAGG6ACTAGAGTGGGTCTCAGCGATTTCTGG TGATG6TTATCGTACATACTACGCAGA'：TCCGTGAAAG6CCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCTTGGGTATTTTGACTACT GGGGTCGGGGAACCCTGGTCACCGTCTi：GA6C (SEQ ID NO: 808) BMS3h-37-3 GAGGTGCA6CTGTTGGA6TCTGGGG6Ai]6CTTGGTACAGCCT6GGGG6TCCCT6CGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTT6AGTGGTAT6AGAT6CAGT<3G6TCCGCCG6GCTCCAGGGAAG6GTCTA6A6TGGGTCTCAGCGATTTCTGG TGATGGTTATCGTACATACTACGCAGACTCCGTGAAAGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGA6GACACC6CGGTATATTACTGTGCGAAAGAGCTTGGGTATTTTGACTACC GGGTTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 809) BMS3h-37-4 GA6GTGCAGCTGTTGGAGTCT6GGG6AI3GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTT6AGTGGTAT6AGATGCAGTI3GGTCCGCAAGGCTCCAGGGAAG6GTCTAGAGTGGGTCTCAGCGATTTCTG6 TGATGGTTATCGTACATACTACGCAGACTCCCTGAAAGGCCGGTTCACCATCTCCCGCGACAA 丁 TCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCTTGGGTATTTTGACTAC 丁 GGGGTC6GGGAACCCTGGTCACCGTCTi：GAGC (SEQ ID NO： 810) BMS3H-37-5
GAGGTGCAGCTGTTGGAGTCTGGGG6A*iGCnGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGTGGTATGAGATGCAGT(5GGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGATCTCAGCGATTTCTGG T6ATGGTTATC6TACATACTACGCAGAaCCGT6AAAGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCC(JAGGACACC6CGGTATATTACTGTGCGAAAGAGCn6GGTATnTGACTACA G6GTTCA666AACCCTG6TCACCGTCTI：6AGC (SEQ ID NO: 811) BMS3h-B7-6 GAGGTGCAGCTGTTG6A6TCTG6GG6A(56CTT6GTACAGCCTG6GGGGTCCCT6CGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTTGAGTG6TATGAGAT6CAGT<36GTCCGCCGGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCGATTTCT6G T6ATG6TTATCGTACATACTAC6CAGAaCCGTGAAAGGCCGGTTCACCATCTCCC6CGACAATTCCGAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCC<；AGGACACCGC6GTATATTACTGTGCGAAAGAGCTT6GGTATTTTGACTACT 66GGTCGGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 812) BMS3h-37-7 GAGGTGCAGCTGTTGGA6ACTGG6GGA<3GCTTGGTACA6CCTGGGGG6TCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGTGGTATGAGATGCAGT<iGGTCC6CCG6GCTCCAGGGAA6GGTCTAGAGTGGGTCTCAGCGATTTCT66 TGATGGTTATCGTACATACTAC6CAGACTCC6T6AAAGGCC6GTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATG6ACAGCCTGCGT6CC<5AGGACACCGCGGTATATTACT6TGC6AAA6AGCTTGGGTAmT6ACTACT GGGGTCGGGGAACCCTCGTCACCGTCACGAGC (SEQ ID NO： 813) BMS3h-37-8 GAGGTGCAGCTGTTGGAGTCTGGGGGA(iGCTTGGTACA6CCTGGGGG6TCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGTGGTATGAGATGCAGT<；G6TCCGCCAGGCTCCA6GGAAGG6TCTA6AGTGGGTCTCAGCGATTTCTG6 T6ATG6TTATCGTACATACTACGCAGACTCC6TGAAAGGCCG6TTCACCATCTCACGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCTTGGGTATnTCACTACT GGGGTCGGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 814) 113· 163920.doc 201245225 BMS3h-37-9 GAG6TGCAGCTGTTGGAGTCTGG6GGAGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGTAGCCTCCGGAT TCACCTTTGAGT6GTATGAGAT6CAGTGGGTCC6CCAGGCTCCAGGGAATGGTCTAGAGTGGATCTCAGC6ATTTCT6G TGATGGTTATCGTACATACTACGCAGACTCCGTGAAAGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATaGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCTTGGGTATTTTGACTACT GGGGTCGGG6MCCCTG6TCACC6TCTCGAGC (SEQ ID NO： 815) BMS3H-37-10 GAGGTGCAGCTGTTGGAOTCTGGGGGAGGCriGGTACAGCCTGGGGGGTCCCTGCGTC 丁 CTCCTGTGCAGCCTCTGGAT TCACCTTTGAGTG6TATGAGATGCAGT6GGTCC6CC6GGCTCCA6GGAAGGGTCTAGAGTGGGTCTCAGCGATATCTGG TGATGGTTATC6TACATACTACGCAGACTCC6T6AAAGGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCTMTGMCAGCCTGCCTGCC6A⑽CACCGCGOTATAHACTGTGCGAAAGAGCHGGGTATHC GGGGTCG6GGAACCCTCGTCACCGTCTC6AGC (SEQ ID NO: 816) BMS3h-37-ll 6AGGTGCA6CTGTTGGAGTCTGG6GGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGTGGTAT6A6ATGCAGT6G6TCC6CAAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCA6CGATTTCTG6 TGATGGTTATC6TACATACTACGCAGACTCC6TGAAAGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGT6CCGAGGACACCGC6GTATATTACTGTGCGAAA6AGCTTGGGrATTTTGACTACA G66GTC6G6GAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 817) BMS3h-37-12 GA6GT6CAGCTGTTGGAGTCTGGGGGA6GCTTGGTACAGCCTG6GG6GTCCATGCGTCTCTCCTGTGCA6CCTCC6GAT TCACCTTTGAGTGGTAT6A6ATGCAGT6G6TCC6CCGG<5CTCCAGGGAAGGGTCTAGAGTGGGTCTCAGC6ATTTCTGG TGAT6GTTATCGTACATACTACGCAGACTCC6TGAAAGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGC6TGCCGAGGACACCGCGGTATATTACTGTGCGAAA6AGCTT6GGTATTTTC5ACTACA GGGGTCGGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 818) BMS3h-37-201 GAGGTGCAGCTGTTGGACTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTCCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTrTGAGTGGTATGAGATGCAGTGGGTCCGCCGGGCTCCAGGGAAGGGAHAGAGTGGGTCTCAATGATTTCCGG GGATG6TTATCGTACATACTACGCA6ACTCC6T6AAAG6CCGOTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6T6CCGAGGACACCGC66TATATTACT6TGC6AAA6AGCTT6GGTATTTTGACTACT GGG6TC6GGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 819) BMS3h-37-202 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCT6GGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGTGGTATGA6ATGCAGTGGGTCCGCCGGGCTCCAG66AA666ACTA6AGTGG6TCTCA6C6ATTTCTGG TGAC66nGGCGCACATACTACGCAGACTCC<5TGAAAGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTC TATCfGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCTTGGGTATTTTGACTACT GGGGTC6GGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 820) BMS3h-37-203 GAGGTGCAGCTGTTG6A6TCTGGG6GAGGCTT6GTACA6CCTGGGGG6TCCCTGCGTCTCTCCTGTGCAGCCTCC66AT TCACCmGGGTGGTATGA6ATGCAGTGGGTCCGCCGGGCTCCAGGGAAGG6ACTA6AGTGG6TCTCA6C6ATTTCTG6 TGAT6GTTATC6TACATACTACGCAGACTCC6TGAMGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCT6CAAAT6AACAGCCTGCGTGCCGAG6ACACCGC6GTATATTAa6TGC6AAAGAGCTGCTCTACTTTGACTACT 6GGGTCG6G6AACCCTG6TCACC6TCTCGA6C (SEQ ID NO： 821) •114·
163920.doc 201245225 BMS3h-37-204 6AG6TGCAGCTGTTG6A6TCT6GG6a\66CTT6GTACAGCCTG6GG66TCCCT6C6TCTCTCCT6TGCA6CCTCCG6AT TCACCTTTGAGTGGTATGAGATGCA6TG6GTCC6CCG6GCTCCAG66AA666ACTAGAGTGG6TCTCA6CGATTTCTGG T6ATG6TTATCGTACATACTAC6CA6>\CTCCGTGAAAGGCCGGTTCACCATCTCCCGCGACAATTCCMGAACACGCTG TATCTGCAAAT ⑽CAGCCTGCGTGO:咖GACACCGCGCTATATTACTOTGCGAAA6AGCTGGGGTTC 6G6GTCGG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 822) BMS3h-37-205 GAG6TGCAGCTGTTGGAGTCTGGGG6/\GGCTT6GTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCC66AT TCACCTTTGAGTG6TATGAGATGCAffrG6GTCC6CCGG6CTCCA6G6AAGGGACTA6AGTG6GTCTCAGCGATTTCTGG TGATGGTTATCGTACATACTACGCAOVCTCC6T6AAA6GCCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCT6CAAATGAACAGCCT6C6T6C<：6AGGACACCGCGGTATATTACTGTGCGAAAGAGTTGGAGTATTTTGACTACT GG6GTCG666AACCCT6GTCACC<3TCTCGAGC (SEQ ID NO: 823) BMS3h-37-206 GA6GT6CAGCTGTTG6AGTCT66G6QVGGCTT6GTACAGCCTG6GGG6TCCCT6C6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6A6T66TATGAGAT6CA^r6G6TCCGCCGGGCTCCAG6GAA66GACTAGA6T6G6TCTCAGCGATTTCT6G T6ATGGmTCGTACATACTAC6CAGyvaCCGTGAAAGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCT6C6TGC(：GAGGATACCGCGGTATATTACTGTGCGAAA6GGTTGGAGTATTTT6ACTACT 66GGTCGG6GAACCCTGGTCACCGTCXGA6C (SEQ ID NO: 824) BMSBh-37-207
GAGGTGCAGCTGTTGGAGTCTGGGGG/iG6CTT6GTACA6CCTGGGGGGTCCCTGCGTCTCTCCTGTGCA6CCTCCGGAT TCACCTTT6AGTGGTATGAGATGCAG:*GG6TCCGCCGG6CTCCAGG6AAGGGACTAGAGTGGGTCTCAGCGATTTCTGG T6AT6GTTATCGTACATACTAC6CA6>^CTCC6TGAAAGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGC<：<3AGGACACCGCGGTATATTACT6TGC6AAAGAGCT66CCTTCTTTGACTACT G6GGTCG66GAACCCTGGTCACCGTCVC6AGC (SEQ ID NO： «25) BM5Bh-37-208 GAGGTGCAGCTGTTG6AGTCTGGGGGAGGCTTGGTACAGCCTGGGG6GTCCCTGC6TCTCTCCTGTGCA6CCTCCG6AT TCACCTTT6AGTGGTATGAGATGCAGr6G6TCCGCCGGGCTCCAGGGAAGGGACTAGA6TG6GTCTCA6C6ATTTCTGG T6ATGGTTATCGTACATACTACGCA6y^CTCC6TGAAAGGCC6GTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCC：6AGGACACCGCGGTATATTACT6T6CGAAA6A6CTCTTGTACTTTGACTACT GG66TCGGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 826) BMS3h-37-209 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTaCCTGTGCAGCCTCCGGAT TCACCTTT6AGT66TATGAGATGCAGTGG6TCCGCCGGGCTCCAGGGAAGG6ACTAGAGT6GGTCTCAGCGATTTCTGG TGATG6TTATCGTACATACTACGCAGACTCCGTGAAAG6CCGGTTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCT6C6T6C(：6AGGACACCGCGGTATATTACTGT6CGAAA6A6TT6GAGTTCTTTGACTACT GGG6TCG6GGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 827) BMS3H-37-210 GAGGTGCAGCTGTTGGAGTCTGGG66A6GCTTGGTACAGCCTGGGG66TCCCT6CGTCTCTCCT6T6CAGCCTCCGGAT TCACCTTTGA6T6GTATGA6ATGCAGT666TCCGCCGGGCTCCAGGGAAGGGACTAGAGTGGGTCTCAGCGATTTCTG6 TGATGGTTATCGTACATACTACGCA6ACTCC6TGAAAGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCOTGCCGAGGACACCGCGGTATATTAC 丁 GTGCGAAAGAGC 了 GCAGTTOTTGACTACT GG6GTCGGGGAACCCTGGTCACC6TCTC6A6C (SEQ ID NO: 828) 163920.doc •115·
S 201245225 BMS3h-37-211 GAGGTGCAGCT6TTG6A6TCT6GGGGAGGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCT6TGCA6CCTCC6GAT TCACCTTTGAGTGGTATGAGATGCAGTGGGTCC6CC6G6CTCCA6GGAAGGGACTAGAGTGGGTCTCA6CGATTTCTG6 T6AT6GTTATCGTACATACTACGCAGACTCCGT6AAAGGCCGGTTCACCATCTCCCGCGACAATTCCMGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CC6AGGATACCGC6GTATATTACTGTGCGAAA6AGCTGCTCTTCTTTGACTACT GGGGTCGGGGAACCCT6GTCACC6TCTCGAGC (SEQ ID NO： 829) BMS3h-37-212 6AG6T6CAGCTGTTGGAGTCTGGGGGAGGCTTGGTACG6CCTGGG6GGTCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6AGT6GTATGAGATGCAGT6GGTCCGCCGG6CTCCA66GAAGGGACTA6A6T6GGTCTCAGC6ATTTCTGG TGATGGTTATC6TACATACTACGCAGACTCC6TGAAAGGCC66TTCACCATCTCCC6CGACAATTCCAA6AACACGCTG TATCT6CAAATGAACAGCCT6CGTGCCGAGGATACCGCG6TATATTACTGTGCGAAAGAGTT6GAGTTCTTTGACTACT G666TCGG66AACCCT6GTCACCGTCTC6AGC (SEQ ID NO： 830) BMS3h-37-213 GAG6TGCAGCTGTT6GAGTCTGGGGeA66CTT6GTACAGCCTGGGGG6TCCCTGCGTCTCTCCT6TGCAGCCTCCG6AT TCACCTTTGA6TGGTATGA6AT6CAGTG6GTCC6CCG6GCTCCA6GGAA6G6ACTAGA6TGGGTCTCAGCGATTTCTG6 TGATGGTTATC6TACATACTACGCAGACTCC6T6AAA66CCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACT6TGCGAAA6AGTT6CTCTTCTTT6ACTACC GGGGTCGGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 831) BMS3h-37-214 GAGGT6CAGCTGTTGGAGTCTGGG6GAGGCTTGGTACAGCCTG6666GTCCCTGCGTCTCTCCTGTGCA6CCTCCG6AT TCATCTTTGA6TGGTATGAGATGCAGTGGGTCCGCCGGGCTCCA6GGAAGG6ACTAGAGTGG6TCTCA6CGATTTCTGG TGATGGTTATCGTACATACTACGCAGACTCCGT6AAAG6CCG6TTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCOTGCCGAGGATACCGC6GTATATTACTGTGCGAAAAACTTGGAGTATTTTGACTACT GGGGTCG6G6AACCCTGGTCACCGTCTCGAGC (SEQ 10 NO： 832) BMS3H-37-215 GAGGTGC6GCTGTTGGAGTCTGG666AGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCA6CCTCCG6AT TCACCTTTGAGTGGTATGAGATGCAGTGGGTCCGCCGGGCTCCAGGGAAGGGACTAGAGTGGGTCTCAGCGATTTCTGG 了 GATGGTTATCGTACATACTACGCAGACTCCGTGAAAG6CCGGTTCACCATCTCCCGCGACAATTCCM6AACACGCTG TATCTGCAAATGAACA6CCT6C6TGCCGAGGACACC6CG6TATATTACTGTGC6AAAGAGTTGCAGTTCTTTGACTACT 6GG6TCGGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 833) BMS3h-38-l 6AG6TGCA6CTGTTGGG6TCTGGGGGA66CTT66TACAGCCTGG666GTCCCT6C6TCTCTCCT6T6CAGCCTCCGGAT TCACCTTT6A6GAGGA66A6ATGATTT666TCCGCCA66CTCCAG6GAAGG6TCTA6A6TG66TCTCAGCTATTAGTGG TAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCMGAACACGCTG TATCTGCAAATGAACAGCCTGCGTeCCGAGGATACCGCGGTATATTACTGTTCOAAAGAGCCGTnXGTTTTGACTAC 丁 GGG6TCA6GGAACCCTGGTCACCGTCTC6A6C (SEQ ID NO: 834) BMS3h-38-2 GAGGTGCA6CTGTTGGC6TCT6GGGGAG6CTTGGTACA6CCTG6GGGGTCCCTGC6TCTCTCCT6C6CA6CCTCCGGAT TCACCTTT6A6GA6GAGGA6ATGATTTG6GTCCGTCA6GCTCCAG6GAAGGGTCTAGAGTG6GTCTCA6CTATTAGTGG TAGTC6TGGTAGCACATACTAC6CAGACTCCGTGAA6GGCC6GTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGC6T6CCGAG6ATACC6CGGTATATTACTGTG66AAA6AGCCGTTTCGTTATGACTACT 6GG6TCA6GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 835) 116·
163920.doc 201245225 BMS3h-38-3 6AGGTGCAGCT6TTG6CGTCTG66G(:：A66CTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCC66AT TCACCTTT6AGGAG6AGGAGAT6AnT66GTCC6CCAGGCTCCAGGGAAGGGTCTA6AGT6GATCTCAGCTATTAGT66 AAGTGGTGGTAGCACATACTACGCACACTCCGTGAAGGGCCGGTTTACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGA6GATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 836) BMS3h-38-4 GA66TGCAGCTGTTGGATCCT6GGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCC66AT TCACGTTTGGGAAGGAGGAGATGATTT66GTCCGCCA6GCTCCAGGGAA6G6TCTAGA6TGGGTCTCATCTATTAGT6G TAGTG6TGGTAGCACATACTACGCAGACTCC6T6AAGGGCCGGTTCACCATCTCCC6C6ACMTTCCAGGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCCGAGGATACCGCGGTATATTACTGTGG6AAAGA6CC6TTTCGTTTTGACTACT GG6GTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO： 837) BMS3H-38-5 6AG6TGCA6CT6TTG6GGTa66G66A6GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTTGA6GAGGA66A6AT6ATTrGGGTCCGCCAGGCTCCAGGGAAG66TCTAGAGTGGGTCTCA6CTATTA6TG6 TAGTGGTGGTAGCACATACTAC6CAGACTCC6T6AAGG6CC66TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATAmCTGTGGGAAAGAGCCGTT 了 CGTTTTGACTACT G6GOTCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 838) BMS3h-38-6
GAGGT6CAGCTGTTGGAGCCTGGGGGAGGCTTGGTACAGCCTGGGGGCTCCCT6CGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTGAGGAGGAGGAGATGATTrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTGG TA6TGOTGGTAGCACATACTACGCAa\CTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCTAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTTCGAAAGAGCCGTTTCGmTGACTAa GG66TCAGGGAGCCCTGGTCACCGTCTC6AGC (SEQ ID NO: 839) BMS3h-38-7 GAGGTGCAGCTGTTGGATCCTGGGGGA66CTTG6TACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTTGGGAAGGAGGAGATGATTT6GGTCCGCCAGGCTCCAGGGAAGG6TCTA6AGTGGGTCTCATCTATTA6TGG TAGTGGTGGTAGCACATACTAC6CA6ACTCCGTTAAG66CCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGAGCCGTTACGTTTTGACTACT GGGGTCAG66AACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 840) BMS3h-38-8 GAGGTGCAGCTGTTGGAGTCTGGGGG/VGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCHT 咖 GAGGAGGAGATGATC.GGGTCCGCCA喊 TCCT 咖 AAGGGTCTAGAGTG6ATCTCAGCTATTAGTG6 TAGTG6TGGTA6CACATACTACGCA6iVCTCCGT6AAGGGCC6GTTCACCATCCACCGCGACAATTCTAAGAACACTCT6 TATCTGCAAATGAACAGCCTGC6T6C<：GA66ATACCGCGGTATATTACT6TTCGAAA6AGCCGTTTCGTTTTGACTACA GGGGTCTGG6AACCTTGGTCACC6TC*XGAGC (SEQ ID NO: 841) BMS3h-38-9 6AGGT6CA6CTGTTGGATCCT66GGG/VGGCTT6GTACAGCCTG6GGG6TCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTTGG6AAGGA6GAGAT6ATr；6GGTCCGCCA6GCTCCAG6GAAG6GTCTAGAGT6GGTCTCATCTATTA6TGG TA6TGGTGGTA6CACATACTACGCAG>kCTCC6TGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCA6GAACAC6CTG TATCT6CAAATGAACAGCCT6CGTGC<：GAGGATACCGC6GTATATTACTGT6CGAAA6AGCCGTTACGTTTTGACTACT GGGGTCAGG6GACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 842) •117· 163920.doc 201245225 BMS3h-38-10 GAGGTGCAGCTGTT6GATTCTGGGG6A6GCTTTGTACAGCCT66GGG6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6AG6A66AGGA6AT6ATTTG6GTCCGCCA66CTCCA666AAG66TCTA6A6TG6ATCTCA6CTATTAGT6G TAGT6GTGGTAGCACATACTACGCA6ACTCCGT6AAGG6CC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCC6A66ATACCGC66TGTATTACTeT6CGAAAGAGCCGTTTC6TTTTGACTACT GG66TCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 843) BMS3h-B8-ll GAGGTGCAGCTGTTGGATCCTGGGGGAGGCHGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGA66AGGAGGAGATGATTT6GGTCC6CCAGGCTCCAG66AA6G6TCTA6A6T6GATCTCA6CTATTAGT6G TA6TGGTG6TA6CACATACTAC6CAGACTCC6T6AAGGGCCGOTTCACCATCTCCCGCGACAATTCCAATAACACGCT6 TATCTGCAAATGAACAGCCT6CGTGCCGAGGATACCGCGGTATATTACTGTGGGAGA6AGCCGTTTCGTTTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 844) BM53h-38-12 GAGGTGC6GCTGTTGGAGTCTG6GGAAGGCTTGCTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGAGGAGGAGGAGAT6ATTTGGGTCCGCCAGGCTCCA6GGAAGGGTCTAGA6TGGGTCTCAGCTATTAGT6G TAGT66TGGTA6CACATACTAC6CA6ACTCC6T6AAGG6CCGGTTCACCATCTCACGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAG6ATACCGCGGTATATTACTGTGGGAAA6AGCCGTTTC6TTTT6ACTACT GG6GTCAGG6AACCCT6GTCACC6TCTCGA6C (SEQ ID NO: 845) BMS3h-38-13 GA6GT6CAGCA6TT66AGTCT6GGGGAGGCCTGGTACAGCCT66GG66TCCCTGC6TCTCTCCTGTGCA6CCTCC6GAT TC^CCTH 咖 GA⑽GGAGATGAmGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCT/nTAGTGG TAGT66TGGTAGCACATACTACGCAGACTCC6TGAAGGGCC6GTTCACCATCTCCCGCGACMTTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGA66ATACCGCGGTATATTACT6TGGGAAAGAGCCGTTTC6TTTTGACTACT GGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 846) BMS3h-38-201 GAG6TGCAGCTCTTGGCGTCT6GG66AG6CTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCT6CGCAGCCTCCGGAT TCACCTTTGAGGA6GAGGAGAT6ATTTGGGTCC6TCA66CTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTGG TAGTGGTGGTAGCACATACTACGCA6ACTCCGTGAA66GCC66TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTCTACTACGACTACT GGG6TCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO: 847) BMS3h-38-202 GA6GTGCAGCT6TTGGC6TCTGGGG6A6GCTTGCTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGC6CAGCCTCCGGAT TCACCTTTGAGGAG6AGGAGATGATTT6G6TCCGTCA6GCTCCAGG6AAGGGTCTAGAGTG6GTCTCAGCTATTAGTGG TAGT6GTC6TAGCACATACTAC6CAGACTCC6TGAA6GGCCG6TTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACC6CG6TATATTACTGTGG6AAAGAGCC6TTCTACTTCGACTACT GGG6TCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 848) BMS3h-38-203 GAG6TGCAGCTGTT6GCGTCTGGGGGAGGCTTGGTACA6CCT6GGGGGTCCCT6C6TCTCTCCTGCGCAGCCTCCG6AT TCACCTTT6A6GA6AAGGA6ATGATTTGGGTCCGTCAGGCTCCAGGGAAGG6TCTAGAGTGGGTCTCAGCTATTAGTGG TAGTGGTG6TAGCACATACTAC6CAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGC66TATATTACTGTG66AAAGAGCCGTTCTTCTACGACTACT GG6GTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 849) •118·
163920.doc 201245225 BMS3H-38-204 GAG6T6CA6CT6TTG6C6TCTGGGGGAGGCTTGGTACAGCCTGG6G6GTCCCT6CGTCTCTCCT6CGCAGCCTCCGGAT TCACCTTTCCCCAGGAGGA6ATGATTTG6GTCCGTCAGGCTCCA(3G6AAGGGTCTAGAGTGGGTCTCAGCTATTAGTG<3 TAGTGGTGGTAGCACATACTACGCAGACTCCGTGAA666CC6GTTCACCATCTCCCGCGACAATTCCAA6AACAC6CTG TATCT6CAAATGAACAGCCTGC6TGCC6AGGATACC6CGGTATATTACTGT6G6AAAGA6CCGTTTCGTTAT6ACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 8S0) BMS3h-38-205 GAG6T6CAGCTGTTGGC6TCTGGG6GAGGCTTGGTACAGCCT66G6GGTCCCTGCGTCTCTCCTGC6CAGCCTCC66AT TCACCTTTTTCGCCGCC6A6ATGATTTGGGTCCGCCAG6CTCCA666AAGGGTCTAGAGT6GGTCTCAGCTATTAGT6G TAGTGGTGGTAGCACATACTACGCA6ACTCCGTGAAGGGCC66TTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCT6CAAATGAACAGCCTGCGTGCC6AGGATACC6CG6TATATTAGrGTG66AAAGAGCC6TTTC6TTAT6ACTACT GG6GTCA6GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 851) BMS3h-38-206 GAG6TGCAGCT6TT6GCGTCTGGGG6i\GGCTT6GTACA6CCTG6G6GGTCCCTGCGTCTCTCCTGCGCAGCCTCC6GAT TCACCTTT6A6GAGGA6GA6ATGATTTGGGTCCGCCA6GCTCCA6GGAAGGGTCTAGAGTG6GTCTCAGCTATTAGTA6 GCCCGGTACGAGCACATACTACGCAGftCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGC〔GAGGATACCGCGGTATATTACTGTGGGAAA6AGCCGTTTCCiTTAT<5ACTACT GG6GTCA666AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 852) BMS3H-38-207
GAG6TGCA6CTGTTGGCGTCTGGG6GA6GCTTGGTACA6CCTGGGGGGTCCCTGCGTCTCTCCT6CGCAGCCTCC6(5AT TCACCTTT6A6GAGGAGGA6ATGATTrGGGTCCGCCAGGCTCCA6GGAAG6STCTAGAGTGGGTaCAGCTATTA6TCG GATGGGTTTCAGCACATACTACGCAGACTCCGT6AAGG6CC6GTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGC6TGC-：6AGGATACC6CG6TATATTACT6TGGGAAAGAGCC6TTTC6TTATGACTACT GGG6TCA6GGAACCCTG6TCACC6TCTCGAGC (SEQ ID NO： 853) BMS3h-38-208 GAGGTGCAGCT6TTGGC6TCTG6G6a^66CTT66TACAGCCTGGGG6GTCCCTGCGTCTCTCCTGCGCA6CCTCCG6AT TCACCTTT6AGGAGGAG6A6ATGATTTGG6TCCGCCAGGCTCCAG66AAGG6TCTAGAGTGGGTCTCA6CTATTAGTCG GTGGGGTCACAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCC6A6GATACC6C66TATATTACTGTGG6AAA6AGCC6TTTC6TTAT6ACTACT GGG6TCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 854) BMS3h-38-209 6AGGT6CAGCTGTTGGC6TCTG6GGGA6GC!TG6TACAGCCTG6GGGGTCCCT6C6TCTCTCCTGC6CA6CCTCCGGAT TCACCTTTGAGGAGGAG6AGATGATTrG6GTCCGCCA6GCTCCA6G6AAG66TCTA6AGTGG6TCTCAGCTATTAGTCG CCTCGGTTGGAGCACATACTACGCAGXCTCC6TGAAGGGCC6GTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCT6CAAATGAACAGCCTGC6T6CCGAGGATACCGCGGTATATTACTGT6G<3AAAGAGCCGTTTCGTTATGACTACT GGG6TCAGG6AACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 855) BMS3H-38-210 6AGGTGCA6CTGTTGGCGTCTGGGG6i；6GCTT66TACAGCCTGGGGGGTCCCTGC6TCTCTCCT6CGCAGCCTCCGGAT TCACCTTTGAGGAGGAG6A6ATGATTT6GGTCC6TCAGGCTCCAG66AAGGGTCTAGAGTG6GTCTCAGCTATTAGTCG CT6GG6T6CCA6CACATACTACGCAGACTCCGTGAAGGGCC6GTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACA6CCTGC6TGCi：GAGGATACCGCGGTATATTACTGTGG6AAAGAGCCGTTTC6TTATGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 856) •119· 163920.doc 201245225 BMS3h-38-211 GAGGTGCAGCT6TTG6CGTCTGGGGGAGGCTTG6TACAGCCT6GGGG6TCCCTGC6TCTCTCCTGCGCAGCCTCCG6AT TCACCTTT6AGGAGGAGGA6ATGATTTGGGTCCGTCA6GCTCCAGGGAA66GTCTAGA6T6GGTCTCAGCTATTA6TAG 6CAG6GT6GGAGCACATACTACGCAGACTCCGTGAAGG6CCGGTTCACCATCTCCC6TGACMTTCCAAGAACAC6CTG TATCTGCAAAT6AACAGCCTGCGTGCCGAGGATACCGCG6TATATTACTGTG6GAAAGA6CCGTTTC6TTATGACTACT GGGGTCAGGGAACCCTGOTCACCGTCTCGAGC (SEQ ID NO: 857) BMS3h-38-212 GAG6TGCAGCTGTTGGCGTCTGGGGGAGGCTTGGTACAGCCT66GG66TCCCTGCGTCTCTCCTGC6CAGCCTCCG6AT TCACCHTGAGGAGGAGGA^TGATTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTGT 6TCCG6TTGGA6CACATACTAC6CAGACTCCGT6AAG6GCCGGTTCACCATCTCCCGCGACAATTCCAA6AACAC6CTG TATCTGCAAATGAACA6CCTGCGTGCCGAGGATACCGCG6TATATTACTGTGGGAAAGAGCC6TTTCGTTATGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 858) BMS3h-38-213 GA6GT6CAGCTGTTGGCGTCTGG66GAGGCTTGGTACA6CCT6GGGG6TCCCTGCGTCTCTCCTGCGCAGCCTCCG6AT TCACCTTTGA6GAG6AG6AGATGATTTG6GTCC6CCAG6CTCCAGGGAAG6GTCTAGAGTGGGTCTCAGCTATTAGTCG GTGG6GTTGGA6CACATACTACGCA6ACTCCGT6AAGG6CCG6TTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCT6C6T6CC6AG6ATACCGC6GTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACT 6GGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 859) BMS3h-38-214 6AG6TGCAGCTGTTGGC6TCTGGG66A6GCTTG6TACA6CCTGGGGG6TCCCTGCGTCTCTCCT6C6CAGCCTCC6GAT TCACCTTTGAGGAGGAGGA6ATGATTTGGGTCCGCCAG6CTCCAGGGAAG6GTCTAGAGTGGGTCTCAGCTATTAGTCG 6AACGGTC 了 GAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCTC TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTCGGAAAGAGCCGTTTCGTTATGACTACT G66GTCAGGGAACCCT6GTCACCGTCTCGA6C (SEQ ID NO： 860) BMS3h-38-215 6AGGTGCA6CTGTTGGCGTCTGGG6GAGGCTTGGTACAGCCTGGGG6GTCCCTGC6TCTCTCCTGCGCAGCCTCC6GAT TCACCTTTGAG6AG6A6GAGATGATTTG6GTCC6CCAG6CTCCA6GGAAGGGTCTAGAGT666TCTCAGCTATTAGTG6 GCT6GGTT6GAGCACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAAT6AACA6CCTGC6TGCC6AG6ATACCGC6GTATATTACTGTGG6AAA6A6CC6TTTCGTTATGACTACT GG6GTCAGG6AACCCT6GTCACCGTCTCGA6C (SEQ ID NO： 861) BMS3h-38-216 GAGGTGCAGCTGTTGGCGTC 丁 GiGGGGAGGCTTGGTACAGCCTGGGGGCTCCCTGCGTCTCTCCTCCGCAGCCTCCGGAT TCACCTTTGAGGAGGAGGAGAT6ATTTGG6TCC6CCA6GCTCCAGG6AA6G6TCTAGAGT6G6TCTCAGCTATTAGTGC 6TTG6GTTG6AGCACATACTACGCA6ACTCCGTGAAGGGCCG6TTCACCATCTCCC6CGACAATTCCAA6AACAC6CTG TATCTGCAAATGAACAGCOTGCGTGCCGAGGATACCGCGOTATAHACTGTGGGAAAGAGCCGTTTCGTTATGACTACT GGGGTCAGGGAACCCT66TCACC6TaCGA6C (SEQ ID NO: 862) BMSBh-38-217 GAGGTGCAGCT6TTGGCGTCTGGGGGA6GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGC6CAGCCTCCG6AT 丁 CACCTTTCAGGAGGAGGAGATGATTTGGGTCCGCCAGGCTCCAGGGMGGGTCTAGAGTGGGTCTCAGCTATTAGTCG CAGGG6TTACAGCACATAGTACGCA6ACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACA6CCT6C6T6CC6A6GATACCGCGGTATATTACTGTG6GAAAGAGCCGnTCGTTATGAaACT GGGGTCA66GAACCCTG6TCACCGTCTC6AGC (SEQ ID NO: 863) •120·
163920.doc 201245225 BMSBh-38-218 GA66TGCA6CT6TTGGCGTCTG6GGGAGGCTTG6TACAGCCTG6GG66TCCCT6C6TCTCTCCTGCGCAGCCTCCGGAT TCACCTTTGAGGA66AG6A6AT6ATTrGG6TCCGTCA6GCTCCAGG6AAGGGTCTAGA6T6i3GTCTCAGCTATTAGTAG GCACGGTTGGAGCACATACTACGCAGiXCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACT GGG6TCAGGGAACCCT6GTCACC6TCTCGAGC (SEQ ID NO： 864) BMS3h-38-219 GA<3GTGCAGCTGTTGGCGTCTGGGG6AGGCTTGGTACAGCCTGGGGGGTCCCTGCGTaaCCTGCGCAGCCTCC66AT TCACCTTTGAGGAG6A6GA6ATGATTTGG6TCCGCCAG6CTCCA6G6AAGGGTCTA6AGTGG6TCTCAA6CATTA6CA6 GAGTGGTGGTAGCACATACTACGCA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGC(：GA6GATACCGCG6TATATTACTGTGGGAAA6A6CCGTTTCGTTATGACTACT 666GTCAGGGAACCCTG6TCACCGTC1CGAGC (SEQ ID NO： 865) BMS3h-38-220 6AG6TGCAGCT6TTGGC6TCT6GG6G/(GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGCGCAGCCTCCGGAT TCACCTTTGAG6A6GAGGAGATGATTT6GOTCCGCCAGGCTCCAG66AAGG6TCTAGA6TG66TCTCAGCTATTA6TCG GATCGGTAACAGCACATACTACGCAGACTCC6T6AAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAAT6AACA6CCT6CGT6C(：6AGGATACCGCGGTATATTACTGTGGGAAA6AGCCGTTTCGTTATGACTACT G6GGTCAGGGAACCCTGGTCACC6TCTC6A6C (SEQ ID NO： 866) BMS3h-38-221
6AG6TGCAGCTGTTGGCGTCTG6GGG/tG6CTTG6TACAGCCTGGGGG6TCCCTGCGTCTCTCCTCC<iCAGCCTCCGGAT TCACCTTTGAGC3AGGAGGAGATGATTTG66TCCGCCAGGCTCCAGGGAAGGGTCTA6AGTGGGTCTCAGCTATTAGTGG GCACG6TTGGAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAAT6AACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCC6TTTC6TTATGACTACT GGGGTCAGGGAACCCTGGTCACCGTCICGAGC (SEQ ID NO： 867) 8MS3h-38-222 6A66T6CAGCTGTT6GC6TCTGGGGG^,GGCTT6GTACAGCCT66GGGGTCCCT6C6TCTCTCCTGC6CA6CCTCCGGAT TCACCTTTGAGGAGGAGGAGATGATnGGGTCCGCCAGGCTCCAGG6AAGGGTCTAGA6T66GTCTCAGCTATTTCGAG OTGGGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGHCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATC 了 GCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATAHACTGTGGGAAAGAGCCGTTTCGTTATGACTACT GGGGTCAGGGAACCCTG6TCACCGTC1CGAGC (SEQ ID NO: 868) BMS3h-38-223 6AGGTGCAGCTGTT6GCGTCT66GGG/1GGCTTG6TACAGCCTGGGGGGTCCCTGC6TCTCTCCTGCGCAGCCTCCGGAT TCACCTTTGAGGAG6AGGAGATGATTT6G6TCC6TCAGGCTCCAG6GAAG66TCTAGAGTGGGTCTCA6CTATTA6TG6 TAGTGGTGGTAGCACATACTACGCAG^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGMCAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTCATGTATGACTACT GGGGTCA6G6AACCCTG6TCACC6TCTC6AGC (SEQ ID NO: 869) BMSBh-38-224 GAGGTGCAGCTGTTGGCGTCT6GGGG/iGGCTTG6TACAGCCTG6G6G6TCCCT6CGTCTCTCCTGCGCAGCCTCCG6AT TCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGTCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTGG TA6TG6TG6TA6CACATACTACGCAG^CTCC6T6AAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTCCCGTACGACTACT GGGGTCAGGGAACCCTGGTCACCGTaCGAGC (SEQ ID NO: 870) -121· 163920.doc 201245225 BMS3h-38-225 GAGGT6CAGCT6TTGGCGTCTG6G6GAGGCTTGGTGCA6CCT66GGGGTCCCT6CGTCTCTCCTGCGCAGCCTCCGGAT TCACCTTTGAG6AGGA6GAGATGATTTGGGTCCGTCAG6CTCCAG66AAG66TCTAGAGT6GGTCTCAGCTATTA6TGG TAGTGGTGGTGGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACA6CCTGCGTGCC6A66ATACCGCG6TATATTACTGTGG6AAA6A6CC6TTTCGTTATGACTACT G6GGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 871) BMSBh-38-226 GAGGTGCAGCTGTTGGCGTCTGG66GAGGCTTGGTACA6CCT6G6GG6TCCCTGC6TCTCTCCTGCGCA6CCTCCGGAT TCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGTCAGGC 了 CCAGGGAAGGOTCTA6AGTGGGTCTCAGCTATTAGTGG TAGTGGTG6TA6CACATACTACGCA6ACTCC6T6AAG6GCCG6TTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAAT6AACAGCCT6CGTGCC6AG6ATACC6CGGTATATTACTGTG6GAAAGAGCCGTT6TACTAT6ACTACT GGG6TCA6G6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 872) BMS3h-38-227 GA6GT6CAGCT6TTG6CGTCT6GGG6AGGCTTGGTACAGCCTGG6G®5TCCCTGCGTCTCTCCTGC6CAGCCTCCGGAT TCACCTTT6AGGAGGAGGAGATGATTTGG6TCCGTCAGGCTCGVGG6AAG6GTCTAGAGTGGGTCTCAGCTATTAGTGG TAGTGGTGOTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGA6GATACCGCGGTATATTACTGTGGGAAA6AGCCCATGTACTATGACTACT GG66TCA6GGAACCCTGGTCACCGTCTC6A6C (SEQ ID NO： 873) · BMSBh-38-228 GAGGTGCAGCTGTTGGCGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6CGCAGCCTCC6GAT 了 CACaTTGAGGAGGAGGAGATGATTTGGOTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTAG 6AACGGTTTCAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAA6AACAC6CT6 TATCTGCAAAT(3AACA<3CCTGC6TGCCGAG6ATACCGCGGTATAHA(TGTGG6AAAGAGCC<5mCG 丁 TATGACTAC 了 GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 874) BMS3h-38-229 GAGGTGCAGCTGTTGGC6TCTGGG66AGGCTTGGTACAGCCTG6GGGGTCCCTGC6TCTCTCCTGCGCA6CCTCCG6AT TCACCTTTGAGGAGGAGGAGATGAT 丁 TGGGTCCGCCAGGC 丁 CCAGG(3AA(3GGTCTAGAGTG<3<3TCTCAGCTAHA6TCG CACGGGTGGGAGCACATACTACGCAGAaCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCCGAGGATACCGCGGTATATTACT6TGGGAAAGAGCC6TTTCGTTATGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 875) BMS3h-38-230 GAG6TGCAGCTGTTG6CGTCTGGGGGAGGCTTGGTACAGCCTGGGG6GTCCCTGC6TCTCTCCTGCGCAGCCTCCGGAT TCACCTTT6AGGAGGAG6AGAT<3ATTTG6GTCC6CCAGGCTCCAGG6AA6GGTCTAGA6TGGGTCTCA6CTATTAGTC6 GGAGGGT6GGAGCACATACTACGCA6ACTCCGT6AAGG6CCG6TTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATaGCAAATGAACAGCCT6CGT6CCGAG6ATACCGC6GTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACT 6GG6TCA6GGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 876) BMS3h-38-231 6AG6TGCAGCT6TTGGCGTCT66G6GAG6CTTGGTACA6CCTGGGGG6TCCCTGCGTCTCTCCTGCGCAGCCTCC6GGT TCCCCTTTGAG(3A6GA6GAGAT6ATTTG66TCC6CCAGGCTCCAGG6AAGGGTCTAGAGTGG6TCTCAGCTATTAGTCG GCAG6GTTGGAGCACATACTAC6CAGACTCCGTGAA6GGCC6GTTCACCATCTCCCGC6ACAATTCCAAGAACACGCT6 TATCTCCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTAC 了 G666TCAGGGAACCCTG6TCACCGTCTC6A6C (SEQ ID NO： 877) -122·
163920.doc 201245225 BMS3h-38-232 GA6GTGCAGCTGTTGGCGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6C6CA6CCTCC66AT TCACCTTTGAGGAGGAGGA6AT6ATTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGA6T6GGTCTCAGCTATTAGTAG 6GGCGGT6GGAGCACATACTACGCAG/ICTCCGTGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAAT6AACAGCCTGCGT6C(：GA6GATACCGCGGTATATTACTGTG6GAAA6AGCCGTTTCGnAT6ACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 878) BMS3h-38-233 GAGGTGCAGCTGTTGGCGTCTGGGGGAGGCnGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGCGCAGCCTCCGGAT TCACCTTTGAGGAGGAGGAGAT6ATTTGGGTCCGCCAG6aCCAGGGAA6GGTCTAGAGTGGGTCTCAGCTATTA6TCG CACGGGTTACAGCACATACTACGCAG/^CTCCGTCAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCC6AGGATACCGCGGTATATTACTGTGGGAAAGAGCC6TTTCGTTATGACTACT G6GGTCAG6GAACCCTGGTCACC6TCTC6A6C (SEQ ID NO: 879) BMS3H-B8-234 GAG6TGCAGCTGTT6GC6TCT66GGGAGGCTTGGTACAGCCTGG6GGGTCCCT6CGTCTCTCCTGC6CAGCCTCCG6AT TCACCTTTGAGGA6GAG6AGATGATTrGGOTCCGCCA6GCTCCAG66AA6GGTCTAGAGT6GGTCTCAGCTATTA6TAG 6AACGGTAGGAGCACATACTACGCAGACTCC6TGAAGG6CCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCT6CGTGCCGAG6ATACCGCGGTATATTACT6TG6GAAAGAGCCGTTTCGTTATGACTACT GGG6TCAGG6MCCaG6TCACC6TCrC6AGC (SEQ.ID NO： 88Θ) BMS3h-B8-235
GAGGTGCAGCTGTT66COTCT6G6GGA66CTTGGTACAGCCTG6GGGGTCCCTGCGTCTCTCCTGC6CAGCCTCCG6AT TCACCTTTGAGGAGGAGGAGATGAmGGOTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTAG GAACGGTTACAGCACATACTAC6CA6；OCC6TGAAG6GCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACT GGGGTCAGGGAACCCTGGTCACCGTCVCGAGC (SEQ ID NO： 881) BMS3h-38-236 GA66T6CAGCTGTT6GC6TCTGGGGGAG6CTT6GTACAGCCTG66GG6TCCCTGCGTCTCTCCTGC6CAGCCTCCGGAT TCACCnrTGAGGAGGAGGA6ATGATrr6G6TCC6CCAGGCTCCAG6GAA6G6TCTA6AGTGGGTCTCAGCTATTAGTAG GAAGGGTAGCAGCACATACTACGCAGACTCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACA6CCT6CGTGC<：GAG6ATACCGCGGTATATTACTGT6GGAAAGAGCCGTTTCGTTAT6ACTACT GGGGTCA6G6AACCCT66TCACCGTCVCGAGC (SEQ ID NO： 882) BMS3lv38-237 GAGGTGCAGCTGTTGGC6TCTGG6GG；^GCTTG6TACAGCCTGGGGGGTCCCTGCGTCTCTCCTGC6CAGCCTCCG6AT TCACCTTT6A6GAG6AGGAGATGATr*66GTCCGCCAGGCTCCAGG6AAG66TCTAGA6TG66TCTCAGCTATTA6TCG GGGCGGTTGGAGCACATACTACGCAGAC 了 CCGTGAAGGGCCGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGC<：GAG6ATACC6CGGTATATTACT6TGG6AAAGAGCCGTTTCGTTATGACTACT GG6(3TCAGGGAACCCTGGTCACC6TC*rCGAGC (SEQ ID NO： 883) BMS3h-B8-238 GAGGTGCAGCTGTTGGCGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGCGCAGCCTCCGGAT TCACCTTTGAGGAGGAG6AGATGATTrGG6TCCGCCAGGCTCCAGGGAAGGGTCTA6A6TGGGTCTCAGCTATTAGTC6 CTC6GGTTACAGCACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCTGCGT6C<：6A6GATACC6CGGTATATTACTGTGGGAAAGA6CCGTTTC6TTATGACTACT GGGGTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO： 884) •123- 163920.doc · 201245225 BMS3h-38-239 GAG6TGCA6CTGTT6GCGTCTG6GGGAGGCTT6GTACAGCCTGGG6GGTCCCTGC6TCTCTCCTGC6CAGCCTCCGGAT TCACCTTTGAGC5AGGA6GAGATGATTTGGGTCCGCCAGGCTCCA6GGAA6GGTCTA6AGTGGGTCTCAGCTATTAGTAG 6AACGGTAT6AGCACATACTACGCAGACTCC6T6AAG6GCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCT6CAAATGAACA6CCT6C6T6CCGAGGATACCGCGGTATATTACT6TG6GAAAGAGCCGTTTCGTTAT6ACTACT GG66TCA6GGAACCCTG6TCACC6TCTCGA6C (SEQ ID NO: 885) BMS3h-38-240 6AG6TGCAGCTGTTG6AGTCTGGG6GAG6CTTG6TACAGCCT66GG66TCCCTGCGTCTCTCCTGCGCAGCCTCC6GAT TCACCTTT6AGGA6GAGGAGATGATTTGGGTCCGCCAGGCTCCA6GGAAG6GTCTA6AGTGGGTCTCAGCTATTAGTAG GAACGOTTACAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAAT6AACAGCCTGC6T6CC6AG6ATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACT GG66TCA6G6AACCCT66TCACCGTCTC6AGC (SEQ ID NO: 886) BMS3H-41-1 GA6GT6CAGCTGTTGGA6TCTGGGGAAGGCTTG6TACA6CCT6G6GGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTACTGAGCAT6AGAT6ATTT6G6TCCGCCA6GCTCCAGGGAAGG6TCTG6AGTGGGTCTCATCTATTTCGG6 了 AATGGTGCTAATACATACTACGCAGAC 了 CC6T6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGMCACGCTG TATCTGCAAAT6AACAGCCTGC6TCCCGAGGACACCGCG6TATATTACTGTGCGAAAGAGCCGCTTAGGTTTGACTACT GGG6CCAGG6AACCCTG6TCACCGTCTCGA6C (SEQ ID NO: 887) BMS3H-41-2 6AGGTGCAGCTGTTGGA6TCTGGGGGAGGCTTGGTACAGCCTGGG6GGTCCCTGC6TCTCTCCTGTGCAGCCTCC6GAT CCACCTTTACTGAGTATGAGATGATTT6G6TCCGCCAGGCTCCAG6GAAGGGTCTGGAGTGGATCTCATCTATTTCGGG TAATGGTGCTMTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCC6A6GACACC6C6GTATATTTCTGT6C6AAA6AGCCGCTTA6GTTTGACTACA GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 888) BMS3h-41-3 6AGGTGCA6CTGTTGGAGCaGGGGGAGGCTTG6TACAGCCTG66GGGTCCCTGC6TCTCTCCTGTGCAGCCTCC6GAT TCACCTTTACTGAGTATGAGAT6ATTTGGGTCCGCAAGGCTCCAGGGAAGG6TAT6GA6TGGGTCTCATCTATTTCGGG TAATGGTGCTAATACATACTACGCAGACTCCGTGAAGGGCCGeTTCACCATCTCCCGCGACAATTCCAAGAACATGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGT6CGAAAGAGCC6CTTAGGTTTGGCTACT GGGGTCAGGGTACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 889) BMS3h-41-4 6AG6T6CA6CTGTT66ATTaGGGGGAGGCTTGGTACAGCCT666GG6TCACTGCGTCTCTCCTGTGCAGCCTCC6GAT TCACCTTTACTGAGTATGA6ATGATTTGGGTCCGCCA66CTCCA666AAGGGTCTG6A6T66GTCTCATCTATTTCG6G TAATGGTGCTAATACATACTACGCAGAC 了 CC6TGAAG6GCCGGTTCACCA1TCTCCCGCGACMTTCCAAGAACACGCTG TATCTACAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTOTGCGAAAGAGCCGCTTAGGTTTGACTACT 6GGGTCGGGGAACCCTG6TCACC6TCTCGA6C (SEQ ID NO： 890) BMS3h-41-5 GAGGTGCAGCTGTTGG6GTCAGGGGGAGGCTTGGTACAGCCTGGG6GGTCCCT6C6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTACTGAGTAT6A6ATGATTTGGGTCCGCCAGGCTCCA6G6AAGAGTCTGGA6TGGGTCTCATCTATTTCGGG TAAT66TGCTAATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCTGC 姆TGMCAGCCTGCGTGCCGAGGACACCGC 前ATAnACTCTGC^AMGAGCCGCHAGCTATCACG^^ GGGGTCA6GGAACCCT66TCACC6TCTCGA6C (SEQ ID NO： 891) • 124·
163920.doc 201245225 6MS3h-41-6 6A6GT6CAGCCGTTGGAGTCTGG66QIG6CTTGGTACA6CCTG6GGGGTCCCT6C6TCTCTCCTGTTCACCCTCC6GAT TCACCTTTAATGA6TATeAGAT6ATTT666TCCGCCAGGCTCCAG6GAAG66TCT66AGTGGGTCTCATCTATTTC6GG TAATGGTGCTAATACATACTACGCAG^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6CCGAGGACACCGCGGTATATTACT6T6C6AAAGAGCCGCTTAGGTTT6ACTACT 6GGGTCAG6GAACCCTGGTCACC6TCTC6AGC (SEQ ID NO: 892) BMS3H-41-7 GAGGTGCAGCTGTTGGAGTCTGGGGAAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACaTTGCTGAGTATGAGATGAlTTGGGTCCGCCAGGCTCCAGGGAAAGGTCTGGAGTGGGTCTCATCTATTTCGGG TAATGGTGCTAATACATACTAC6CAGACTCC6TGAAGG6CC6GTTCACCATCTCCC6C6ACAATTCCAAGAACACGCT6 TATCT6CAAAT6AACAGCCTGC6T6CCGAGGACACC6CGGTATATTACT6TGCGAAA6AGCCGCTTAGGTTTGACTACT G6G6TCAG66AACCCTG6TCACCGTCTCGAGC (SEQ ID NO; 893) BMS3h-41-8 6AG6T6CA6CT6TTGGACCCTGGGGGASGCTT6GTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTACT6AGTCT6AGAT6ATTTG66TCCGCCAG6CTCCAGG6AA6GGTCTGGAGTGGGTCTCATCTATTTC666 AAATGGTGCTAATACATACTACGCGGACTCCGTGAAGGGCCGOTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGOTATATTACTGTGCGAAAGAGCCGCTTAGGTTTGACTACT 6GGGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 894) BMS3h-41-9
GAGGT6CAGCTGTT6GAGCCTGG6GGAGGCTTGGTACAGCCTGGGGGOTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTACTGAGTATGAGATGAmGGGTCCGCAAGGCTCCAGGGAAGGGTATGGAGTGGGTCTCATCTATTTCGGG TAATGGTGCTAATACATACTACGCAGACTCCGT6AAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTCCCGAGGACACCGCGGTATATTACTGTGCGAAAGAGCCGCTTAGGmGACGACT GGGGTCAGGGAACCCTG6TCACC6TCTCGAGC (SEQ ID NO： 895) BMS3h-41-10 6AGGTGCAGCTGTTGGAGTCTGGGGTASGCTTGGTACAGCCT6GG6G6TCCCT6C6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTACTGAGTATGAGATGATTTGGGTCCGCAAGGCCCCAGGGAAGGGTCTGGAGTGGGTCTCATCTATTTCGGG TAATGeTGCTAATACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGC6AAAGAACCGCTTAGGTTTGACAACT GGG6TCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 896) BMS3h-41-ll 6AG6TGCAGrT6TTGGAGTCTCGGG6AGGCTT6GTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTACT6AGCATGAGAT6ATTTGGGTCC6CCAGGCTCCA6G6AAGGGTCTGGAGTGGGTCTCATCTATTTC6GG TAATG6TGCTAATACATACTACGCAGACTCC6TGAA66GCCGGTTCTCCGTCTCCCGCGACAATTCCAAGAACACGCT6 TATCT6CAAATGAACA6CCT6C6T6CCGAGGACACCGCGGTATATTACT6TGCGAAA6AGCCGCTTAGGTTT6ACTACT G66GTCA6G6AACCCT6GTCACCGTCTCGA6C (SEQ ID NO: 897) BMS3K-41-12 GAGGTGCAGCCGTTGGA<3TCT666GGAGGCTT6GTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCTGCCTCCGGAT TCACCTTTACTGACTAT6AGATGATTTGG6TCCGCCAGGCTCCAGGGAAGGGTCTGGA6TGGGTCTCATCTATTrCGGG TAATG6T6CTAATACATACTACGCAGACTCCGTGAAGGGCC66TTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCG6TATATTACT6TGCGAAAGAGCCGCTTAGGTTTGACTACT GGGGTCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 898) •125- 163920.doc 201245225 BMS3h-41-13 GAGGT6CAGCT6TTG6AGTCTGCGGGAGGCTTGGTACAGCCT66G6GGTCCCTGC6TCTCTCCT6T6CAGCCTCCGGAT TCACCTTTGCT6AGTAT6AGATGATTTGGGTCCGCCAGGCTCCA666AAGGGTCTGGA6T6GGTCTCATCAATTTCGGG TAATG6TGCTAATACATACTACGCAGACTCCGTGAA66GCCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCC6A6GACACCGC6GTATATTACT6TGC6AAA6A6CC6CTTAGGTTTGACTACT G66GTCAG6GAGCCCTG6TCACCGTCTCGA6C (SEQ ID NO: 899) BMS3h-41-14 6AGGtGCA6CtGTTG6AGCCTG6G6GAGGCTT6GTACAGCCT6G6GGGTCGCTGC6TCTCTCCT6TGCA6CCTCCGGAT TCACCTTTACT6A6TATGA6ATGATTTGG6TCCGCCAGGCTCCA6G6AA6GGTCT66AGTGG6TCTCATCTATTTC66G TAAT6GTGCTAATACATACTACGCA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCT6CAAATGAACAGCCT6CGT6CCGAG6ACACC6CG6TATATTACT6T6CGAAA6A6CCGCTTAGGTTTGACAACT 6GGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 900) BMSBh-43-1 GAGGTGCAGCTeTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCTCTGCGTCTCTCCTGTACAGCCTCCGGAT 了 CACaTTAATATGTATGAGATGTCGTGGGTC(GCCAGGCTCCAGGGAAG6GTCTAGAGTGGGTCTCAGGTATTAGTAG ACGTGGTTTTACTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCCCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCT6CGT6CCGAGGATACCGCGGTATATTACT6TGCGAAAGAGCCGATTACGTAT6ATTTGA G6TATGCGCGTTTTGACTACTCGG6TCAGGGAACCCTG6TCACC6TCTCGA6C (SEQ ID NO: 901) BMS3h-43-2 6AGGAGCAGCTGTTG6AGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTACAGCCTCCGGAT TCACCTTTAATAT6TAT6AGATGTCGTGG6TCCGCCA6GCTCCAGGGAA6GGTCTA6A6T66GTCTCA6GTATTAGTAG ACGT6GTTTTACTACATACTAC6CAGACTCC6T6AAG66CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCG6TATATTACTGTGCGAAAGAGCCGATTACGTATGCTACGA GGTATGCGCGTTTTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ 10 MO： 9Θ2) BMS3h-43-3 GAGGTGCAGCTGTTGGAGTCTGGG6GAGGCTTGGTACA6CCTGGG6G6TCCCT6C6TCrCTCCTOTACAGCCTCC6GAT TCACCTTTAATATGTATGAGATGTCGTGG6TCCGCCAGGCTCCAGGGAAG6GTCTAGA6TGG6TCTCAGGTATTAGTAG GCGTGGTTTTACTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTTCAAGAACACGCTG TATCTGCAAATGAACAGCCT6CGTGCCGAGGATACC6C6GTAfATTACTGTGCGAAA6AGCCGATTAC6TATGATATGA GGTATGCGCGTTTTGACTAC6GGGGTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO： 9ΘΒ) BMS3h-43-4 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTACAGCCTCCGGAT TCACCTTTAATATGTATGAGATGTCGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTaCAGGTATTAGTAG 6CGTGGTTTTACTACATACTACGCAGACTCCGT6AAGGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCC6AGGATACCGC66TATATTACTGTGCGAAA6AGCCGATTAC6TAT6ATATGA GGTATGCGCGTTTTGACAACTGGGGTCAGGGMCCCTG6TCACCGTCTCGAAC (SEQ ID NO： 904) BMS3h-43-5 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTACAGCCTCC6GAT TCACCTTTAATAC6TATGAGATGTCGTGGGTCCGCCAG6CTCCA66GAAGGGTCTAGAGTGGGTCTCAGGTATTGGTAG GCGTGGnTTACTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCaGCGTGCCGAGGATACCGCGGTA 丁 ATTACTGTGCGAAAGAGCCGATTACGTATGATTTGA GGTATGC6CGTTTTGACTACTC6GGTCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 905) 126·
163920.doc 201245225 BMS3h-43-6 6A6GTGCAGCTGATGGAGTCAGGGG6AGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TACAGCCTCC6GAT TCTCCTTTAATATOTATGAGATGTCGIPSGGTCCGCCAGGC 丁 CCAGGGAAAGGTCTAGAGTGGGTCTCAGGTAHAGTAG 6C6T6GTTATACTACATACTAC6CA6ACTCCGTGAA66GCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG 下 ATCTGCAAATGAACAGCCT(5C(STG(：C<5AGGATACC(5CGGTATATTACTGTGCGAAAGAGCCGATTACGTATGATATGA GGTATGCGC6TTTTGACTACT66GGTCGGGGAACC.CTG6TCACCGTCTCGAGC (SEQ ID NO： 906) BMS3h-43-7 GAGGT6CAGCTGTTGGAGTCTGGGGGAG6CTTGGTGCAGCCTGGGGGGTCCCTGC6TCTCTCCT6TACAGCCTCC6GAT TCGCCTTTAATATGTATGAGAT6TC6T'3G6TCCGCCAG6CTCCA6GGAA6G6ACTAGAGTG6GTaCAG6TATTAGTAG GCATGGTTTTACTACGTACTACGCAGACTCCGTGAAGGGCCGGTTCACCGTCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCT6CGTGCC«5A66ATACC6CGGTATATTACTGTGC6AAAGA6CC6ATTAC6TATGATATGC GGTATGC6CGTTCTGACTACTG66GTCAG6GAACCCTGGTCACCGTCTC6A6C (SEQ ID NO: 907) BMS3h-43-8 GAGGTGCA6CTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGG6GGTCCCTGC6TCTCTCCT6TACAGCCTCC6GAT TCACCTTTAAfATGTATGA6ATGTC6TGG6TCCGCCAGGCTCCAGG6AA6GGTCTA6AGT666TaCA66TATTA6TAG 6CGTG6TTTTACTACATACTAC6CAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAAT6AACAGCCTGCGTGCCi5AGGATACCGCGGTATATTTCTGTGCGAAAGAaCCGATTACGTATGATATGA GGTATGCGCGTTCTGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 908) BMS3h-43-9
GAGGTGCAGCT6nGGA6TCTGGGGGG'5GCTTGGTTCAGCCTG6GGG6TCCCTGC6TCTCTCCTGTACAGCCTCCGGGT TCACCTTTAATATGTATGAGATGTCGT'5GGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTG66TCTCAG6TATTAGTAG GCGTGGTTTTACTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCTGCGTGCCi3AGGATACC6CGGTATATTACTGTGC6AAA6AGCCGATTAC6TAnCTATGA 6GTATGCGCGTTTTGACTACTCGGGTCTGG6AACCATGGTCACCGTCTCGAGC (SEQ ID NO： 909) BMSBh-43-10 GAGGTGCAGCTGCTGGAGTCTGGGGGAI3GCTTGGTACAGCCT6GGGGGTCCCTTC6TCTCTCCT6TACAGCCTCCGGAT 丁 CACCrTTAATATGTATGAGATGTCGIT 彳 5GGTCCGCCAGGCT<XAG<3GAAG<3GTCTAGAGTGGGTCTCAG6TATTAGTAG GCGTGGTTTTACTACATACTACGCAGAi：TCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAAT6AACAGCCTGC6TGCC«3AGGATACCGCG6TATATTACTGT6C6AAA6A6CCGATTAC6TATGATATGA GGTATGCGCGTTTTGACTACAGTGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 910) BMS3h-43-ll GAGGTGCAGCTGTTGGAGTCTGGA6GA^3GCTTG6TACAGCCTGG66G6TCCCTGCGTCTCTCCTGTACA6CCTCCGGAT 了 CACOTTAATATGTAT(3AGATGTCGTi3G6TCCC5CAAGGCTCCAGG(3AAGGGTCTAGAGTGGGTCTCAGGTATTAGTAG GCATG6TTTTACTACATACTACGCAGArrCCGTGAAGGGCC66TTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAAT6AACAGCCTGCGTGCC3AGGATACCGCG6TATATTACT6TGC6AAA6AGCCGATTACGTATGATATGA GGTATGCGCGTTTTGACTACTGGGGTC^GGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 911) BMS3h-43-12 GAGGTGCAGCT6TTCGAGTCTGGGGGA3GCTTGGTACAGCCTGGGGGGTCCCT6C6TCTCTCCTOTACAGCCTCC66AT TCACCTTTAATATGTATGAGATGTCGTSGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGGTATTAGTAG GCGTG6TTTTACTACATACTACGCAGACTCCGTGAAGG6CC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCSAGGATACCGCGGTATATTACTGTGCGAA6GA6CCGATTACGTATGATATGA GGTATGCGCGTTTT6ACTACTGGGGTCS6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: *912) 127- 163920.doc 201245225 BMS3h-43-13 6AGGTGCAGCTGTTGGAGTCTGGGG6AGGCTTGGTACA6CCTGGGGGATCCCT6CGTCTCTCCTGTACAGCCTCCGGTT TCACCTTTAATAT6TAT6AGATGTC6TGGGTCC6CCAGGCTCCAGGGAAGG6TCTAGAGTGG6TCTCAGGTATTAGTA6 GCGTG6TTTTACTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAG6ATACCGCG6TATATTACTGTGCGAAAGAGCCGATTAC6TATGATAT6A 6GTATGCGCGTTTTGACTACTGGG6TC66GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 913) BMS3h-43-14 6AG6TGCAGCT6TTG6AGTCTGGGGGA6GCTC6GTACAGCCTG6G6GGTCCCTGC6TCTCTCCTGTACA6CCTCC66AT TCTCCTTTAATAT6TAT6AGATGTCGT666TCCGCCA6GCTCCA666AAG6GTCTAGA6TG66TCTCAG6TATTA6TAG GCGTGGmTACTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGC 丁 (3 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAA6AGCCGATTACGTATGATAT6A GGTATGCGCGTTTTGACTACT66G6TCAGGGAACCCTGGTCACCGTCTCGGGC (SEQ ID NO： 914) BMS3H-43-15 GAGGTGCAGCTGTT66AGTCTG6G66AG6CTTG6TACAACCTGGGGGGTCCCT6CGTCTCTCCT6TACA6CCTCCGGAT TaCCmMTATCTATGAGATOTCOTGGCTCCGCMGGCTCCAGG⑽G咖CTAGAGTGGCTCTCAGGTAm^ GCGTGGTTTTACTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGTGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGAGGATACCGCGGTATATTACTGTGCGAAA6AGCCGATTACGTATGATATGA 6GTAT6CGCGTTTT6ACTACTGGG6TCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ 10 NO： 915) BMS3h-56-l GA66TGCAGCTGTT6GAGTCTGGGGGAGGCTTG6TACA6CCTGGG6GGTCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTAT6AGAT6TGGTGGGTCCGCCA66CTCCAGG6AAG66TCTAGA6CGG6TCTCAGCTATTAATCC GCAGG6TACGC6TACATACTACGCAGACTCC6TGAA6GGCC6GTTCACCATCTCCC6CGACAATTCCAAGAACAC6CTG TATCT6CAAATGAACAGCCTGC6TGCCGA6GATACCGC6GTATATTACT6TGC6AAACTTCCGTTTACTTTTGAGGACT GG6GTCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 916) BMS3h-56-2 GAGGTGCA6CTGTTG6A6TCT6GGG6AGGCTTGGTACA6CCT6GGGGGTCCCT6CGTCTCTCCT6TGCAGCCTCC66AT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTAnAATCC GCA6GGTACGCGTACATACTAC6CAGACTCCGTGAAGG6CC6GTTCACCATCTCCCGCGACAATTCCAA6AACAC6CTG TATCT6CAAAT6AACAGCCTGCGTGCCGAGGATACCGC6GTATATTACT6TGC6AAACTTCCGTTTACTTTTiSAC6ACT GGGGTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 917) BMS3h-56-3 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCT6GGGGGTCCCTGCOTCTCTCCTGTCiCAGCCTC〔GGAT TCACCTTTCGGGATTATGAGATCTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGC6TACATACTACGCAGACTCC6T6AAGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCA6AGGATACCGCGGTATATTACTGTACGAAACTTCCGTTTATTTTT6AATACT G6GGTCA6GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 918) BMS3H-56-4 GAGGTGCA6CTGTT66AGTCCGG6GGAGGCTTG6TACA6CCTGG6GGGTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCnTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCA66GTACGC6TACATACTACGCAGACTCC6TGAAGGGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCG 下 TTATGTTTCACGACC GGGGTCAGGGAACCCT66TCACCGTCTCGAGC (SEQ ID NO： 919) •128·
163920.doc 201245225 BMS3H-56-5 GA66TGCA6CTGTTGGAGTCT6GGG6Ai3GCTTGGTACAGCCTGGG6GGTCCCTGCGTCTCTCCT6T6CAGCCTCCGGAT TCACCTTTC6G6ATTATGA6AT6TG6Ti3GGTCC6CCA6GCTCCAG66AA6GGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTAC6CAGACTCCGT6ATGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCOSAGGATACCGCGGTATATTACTGTGCGAAACTTCCGmTACmTGACGAC 了 6GGGTCAGGGAACCCTGGTCACCGTCTC6A6C (SEQ ID NO: 92Θ) BMSBh-S6-6 GAGGT6CAGCTGTTGGAGTCTGGGG6A«56CTT66TACAGCCTG6GGGGTCCCTGC6TCTCTCCT6TGCAGCCTCC6GAT 了 CTCCTTTCGGG/nTATGAGATGTGGTiSGTACCGCCAGGC 丁 CCAGGGAAGGGTCTAGAGCGGGTCTCAGCTAHAATCC 6CAG66TACGCGTACATATTACGCAGACTCC6TGAAGGGCC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGC6TGC05AG6ATACC6CGGTATATTACTGTGCGAAACTTCCGTTTATTTTTGACAACC 6GGGTCAGG6AACCCTGGTCACCGTCT>：GAGC (SEQ ID NO: 921) BMS3h-56-7 GA66TGCAGCTGTTGGAGTCT6G66GAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6T6CAGCCTCCGGAT TCACCTTTCGG6ATTATGA6ATGT66TGG6TCC6CCA6GaCCAGGGAA666TCTA6AGCG66TCTCA6CTATTAATCC 6CA6G6TACGCGTACATACTACGCAGAi：TCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6C05AGGATACCTCGGTATATCACT6T6C6AAACCTCCGTTTATTTTTGGCGACT GGG6TCCG66AACCCTG6TCACCGTCTi：6AGC (SEQ ID NO: 922) BMS3H-56-8
GAGGTGCAGCTGTTGGAGTCTGGG6GA<3GCTTGGTACAGCCTGGGGGGTCCCGGCGTCTCTCCTGTGCA6CCTCCG6AT TCACCTTTCGGGAnATGAGAT6TGGP3GGTCCGCCAGGCTCCGGGGAAGGGTCTAGA6C6GGTCTCAGCTATTAATCC GCAG66TACGC6TACATACTACGCAGA-：TCCGTGAA6G6CC6GTTCACGATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCOSAGGATACCGCGGTATATTACTGTGCGAAACnCCGTTTACTTTTGAGGACT GGGGTCAGGGAACCCTGOTCACCCTCTCGAGC (SEQ ID NO: 92B) BMS3h-56-9 C3AGOT6CAGCTGTTGGA6TCT6GG6GA'3GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTATCCT6TGCAGCCTCCG6AT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGA：TCC6TGATG6GCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6CC3A6GATACT6CGGTATATTACTGT6CGAAACTTCCGTTTAT6TTT6AC6ACC GGGGTCA6GGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 924) BMS3h-56-10 GAG6T6CAGCTGTTGGAGTCTGGGGGA'36CTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTjGGTCCGCCAGGCTCCAGGGAAGGTTCTAGAGCGGGTCTCAGCTATTAATCC 6CA6G6TACGCGTACATACTACGCAGA：TCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACATGCT6 TATCTGCAAATGAACAGCCTGCGTGCCSAGGATACTGCGGTATAUAa6TGCGAAACTTCCGTTTAT6TTT6ACGACC GGGGTCAG6GAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 925) BMS3h-56-ll GAG6TGCA6CTGTTG6AGTCTGGGGGASGCTTGGTACAGCCT6G6G66TCCCTGCGTCTCTCCT6TGCAGCCTCC6GAT TCACCTTTCGGGATTATGAGATGTGGTSGGTCC6CCAGGCTCCA6GGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGAGCCGAGGATACTGCGGTATATTACTGTGCGAAACTTCCGTTTATGTTTGACGACC 66GGTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 926) •129· 163920.doc 201245225 BMS3H-56-12 GAGGTGCAGCT6TTGGAGTCTG6GGGAGGCTT6ATACAGCCT6GGGG6TCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTCGG6ATTATGA6AT6T66TGG6TCCGCCAG6CTCCAGGGAA6G6TCTA6AGCGGGTCTCAGCTAnAATCC GCA6GGTAC6C6TACATACTACGCAGACTCC6TGAA66GCC6GTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGATACC6C6GTATATTACTGTTT6AAACTTCCGTTTATTTTCGACTACT 6GGGTCA6G6AACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 927) BMSBh-56-13 GAGGTGCAGCTGTTGGAGTCT6GG6GAG6CTT66TACAGCCT6GGGG6TCCCT6C6TCTATCCTGTGCAGCCTCCG6AT TCACCTTTCGG6ATTAT6AGATGTGGTGGGTCCGCCAGGCTCCAG6GAAGG6TCTAGA6CGGGTCTCAGCTATTAACCC GCAGG6TACGC6TACATACTAT6CAGACTCCGT6AAG66CCGGTTCACCATCTCCCGC6ACAATTCCAAGMCACGCT6 TATCT6CAAATGAACAGCCTGCGTGCC6AT6ATACC6C<3GTATATCACTGTAC6AAACTTCCGTTTATTTTTGACTACT G6GGTCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 928) BMS3h-56-14 GAG6TGCAGCTGTT6GAGTCT6GGGGAG6CTTG6TACAGCCT6GGGGGTCCCT6C6TCTCTCCT6T6CAGCCTCCGGAT TCACCTTTCGGGATTATGA6AT6TGGT6G6TCCGCCAGGCTCCAGGGATGGTTCTA6AGC6GGTCTCAGCTATTAATCC GCAGGGTACGC6TACATACTACGCAGACTCC6TGAA666CCG6TTCACCATCTCCCGCGACMTTCCAAGAACAC6CTA TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTCCGAAACTTCCGTTTTTTTTTGACTCCA GGGGTCAGGGAACCCTGGTCACCGTCTC6A6C (SEQ ID NO： 929) BMS3H-56-15 GAGGTGCA6CTGTTG6A6TCT66G6GAG6CTT66TACAGCCTGGGG6CTCCCT6C6TCTCTCCTGT6CAGCCTCCG6AT TCACCTT 丁 CGGGATTATGAGA 丁 GTGGTGGGTCCGCCGGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCA6GGTACGCGTACATACTAC6CAGACTCT6TGAAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACA6CCTGCGTGCCGAGGATACCGC6GTATATTAaGTGCGAAACTTCCGTTTACTTTT6AG6ACT G6GGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 930) BMS3h-56-16 GAGGTGCAGCTGTTGGAGTCT66GGGAGGCTTG6TACAGCCTGGGGG6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTAT6AGATGTGGTGGGTCCGCCAGGCTCCAGGGAA6GGTCTAGAGCGG6TCTCA6CTATTAATCC 6CAGG6TACGCGTACATACTACGCAGACTCC6TGATGGGCCG6TTCACCATCTCCCGCGACMTTCCAAGAACAC6CTG TATCTGCAAAT6AACAGCCTGCGTGCCGAG6ACACC6C6GTATATTACT6TGC6AAACTTCC6TTTACTTTTGAG6ACT GGGGTCAGGGAACCCT66TCACCGTCTCGA6C (SEQ ID NO: 931) BMS3h-56-17 GAG6TGCA6CTGTTGGA6TCT6GGGGA6GCTTG6TACAGCCTGGG6G6TCCCTGC6TCTCTCCTGTGCAGCCTCC6GAT TCTCCTTTCGG6ATTATGA6AT6T66TG6TACCGCCAGGCTCCAGGGAAGG6TCTA6AGCG6GTCTCAGCTAnAATCC GCAG66TACGC6TACATATTACGCAGACTCC6TGAAGG6CC66TTCACCATCTCCC6CGACAATTCCAAGAACACGCT6 TATCT6CAAAT6AACAGCCT6C6TGCCGAGGACACCGCG(STATATTACTGT6C6AAACTTCCGTTTACTTTTGAGGACT 6G66TCAGGGAACCCT6GTCACCGTCTC6A6C (SEQ ID NO: 932) BMS3h-56-18 GAG6TGCA6CTGTTGGA6TCT6G6G6AG6CTTG6TACA6CCTGG6GG6TCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTC66GATTATGA6ATGT66T666TCC6CCAGGCTCCA6GGAA66TTCTAGAGCG6GTCTCAGCTATTAATCC GCAGG6TACGCGTACATACTAC6CAGACTCC6T6AAGG6CCG6TTCACCATCTCCCGC6ACAATTCCAAGAACAT6CTG TATCTGCAAAT6AACAGCCT6CGT6CC6A6GACACCGCGGTATATTACT6T6C6AAACTTCCGTTTACTTTTGA66ACT GG6GTCA6G6AACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 933) •130-
163920.doc 201245225 BMS3h-56-19 6AGGTGCA6CTGTTGGAGTCTGGG6GASGCTT6GTACA6CCT6GG6G6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGAHATGAGATGTGGTSGCTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAG6GTACGC6TACATACTACGCAGACTCCGTGMGGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCT6CGTGCCGAGGATACC6C6GTATATCACTGTGCGAAACTTCC6TTTACTTTT6AGGACT GGGGTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 934) BM$3h-56-20 GAGGTGCAGCTGTTGGAGTCTGGGGGASGaTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTmGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTaCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGGnCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGC6TGCCSA6GATACCGCGGTATATTACTGTACGAAACTTCC6mACTTTTGAG6ACT G6GGTCAG6GAACCCTGGTCACCGTCTCGAGC <SEQ ID NO： 935) BMS3h-56-21 GAGGTGCAGCTGTTG6AGTCTG6GGGA3GCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTSGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCSAGGATACCGCGGTATATTACTGTTTGAAACTTCCGTTTACTTTTGA6GACT 66GGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 936) BMS3h-56-22
6A6GT6CA6CTGTTG<3AGTCTGGGGGA3GCTTG6TACAGCCTG6G6G6TCCCTGCGTCTATCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGT3G6TCCGCCAG6CTCCAGGGAAGGGTCTA6AGCGGGTCTCAGCTATTAACCC GCAGGGTACGCGTACATACTA 了 GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCSATGATACCGCGGTATATCACTGTACGAAACTTCCGTTTATTTTTGAATACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 937) BMS3H-56-23 GAGGTGCAGCTGTTGOAGTCTGGGGGASGCHGGTACAGCCTGGGGGGTCCCTGCG 了 CTCTCCTGT6CAGCCTCCG6AT TCACCTTTCGGGATTAT6AGATGTG6T3GGTCC6CCA66CTCCAGG6AAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGCTACGCGTACATACTACGCAGACTCCCTGATCGGCCGOTTCACCATCTCCCGCGACMTTCCAAGAACACGGTG TATCTGCAAATGAACAGCCTGCGTGCC3A6GACACCGC6GTATATTACTGTGCGAAAGAACCTTATAGTTTTGACTCCT GG66TCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 938) BMS3h-56-24 6A66TGCAGCTGTTGGAGTCTGGGGGA3GCTTG6TACA6CCTGGG6GGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTAT6A6ATGTG6TS6GTCCGCCAGGCTCCAG6GAAGGGTCTA<5AGCG6GTCTCA6CTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCCGTGATGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCSAGGATACCGCG6TATATCACTGTGCGAAAGAACCTTATAGTTAT6ACTACT GGG6TCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 939) BMS3h-56-25 GA6GTGCAGCTGTT6GAGTCTGGG6GA5GCTTG6TACAGCCTGGG6G6TCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCmCGGGAnATGAGATGTGGTGGGTCCGCCGGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGC6TACATACTAC6CAGACTCCGT6ATGGGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGC6TGCCSAGGATACCGCGGTATATTACT6TGCGAAACTTCCGTTTACTTTTGACGACT GG6GTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 940) 131 · 163920.doc 201245225 BMS3h-56-26 6AGGTGCAGCTGTTG6A6TCTGGGGGAGGCTTG6TACAGCCTGGGGG6TCCCTGCGTCTATCCTGTGCAGCCTCCGGAT TCACCTTTC66GATTAT6A6AT6TGGTGGGTCCGCCG66CTCCAGGGAA6GGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCCGT6ATG6GCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGA6GATACTGCGGTATATTACTGT6CGAAACTTCC6TTTAT(JTTTGACGACC GGG6TCAG6GAACCCTGGTCACC6TCTCGA6C (SEQ ID NO: 941) BMS3h-56-27 GAG6T6CAGCTGTTG6AGTCT6GGGGAG6CTT6GTACA6CCT666GG6TCCCTGCGTCTATCCTGT6CAGCCTCCGGAT TCACCmC6G6ATTATGAGATGTGGTGG6TCCGCCA66CTCCAG6GAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGG6TAC6CGTACATACTACGCAGACTCC6TGATG6GCC66TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACT6CGGTATATTACT6TGC6AAACTTCCGTTTAT6TTTGACGACT G6G6TCA6GGAACCCT6GTCACC6TCTCGA6C (SEQ ID NO: 942) BMS3H-56-28 GAG6TGCAGCT6TT6GAGTGTGGGGGAG6CTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6T6CAGCCTCC6GAT TCACCTTTGCTG6GTAT6A6TTGTG6TGGGTCC6CCAG6CTCCAGGGAAGG6TCTAGAGCGGGTCTCAGCTATTAATCC GCAG66TACGC6TACATACTACGCA6ACTCCGT6AT6GGCC66TTCACCATCTCCCGCGACMTTCCAA6AACACGCTG TATCTGCAAAT6AACAGCCT6CGT6CCGAG6ATACCGCGGTATATTACT6TGCGAAACTTCCGTTTACTTTT6ACGACT 66GGTCACGGAACCCT6GTCACC6TCTCGAGC (SEQ ID NO： 943) BMS3h-5€-29 6AGGT6CAGCTGTTGGAGTCTGGGGGAGGCTT66TACA6CCTGGGGG6TCCCTGC6TCTCTCCT6TGCAGCCTCC6GAT TCACCTTTGCTGGGTATGAGTTGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGG6TACGCGTACATACTACGCA6ACTCCGT6ATGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGT6CC6A66ATACT6CG6TATATTACTGTGCGAAACTTCCGTTTATGTTT6AC6ACC G6GGTCAG6GAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 944) BMS3h-56-30 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCrTGOTACAGCCTGGGGGGTfCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGCTGG6TATGAGATGTG6TGGTTCC6CCAG6CTCCAGGGAAG66TCTA6AGCG6GTCTCAGCTATTAATCC GCAGGGTAC6CGTACATACTACGCAGACTCCGT6AT6G6CC66TTCACCATCTCCCGC6ACAAnCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGOTATATTACTOTGCGAAACTTCCGTTTACTTTTGACGACT GGGGTCAGG6AACCCTGGTCACCGTCTC6A6C (SEQ ID NO: 945) BMS3h-56-Bl 6AGGTGCAGCTGTTGGA6TCTGGG6GAGGCTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCTGTGCA6CCTCC6GAT TCACCTTTGCTGG6TATGAGATGT66TG6TTCCGCCA6GCTCCAGGGAAG66TCTA6AGCGGGTCTCAGCTATTAATCC GCAGGGTACGC6TACATACTACGCAGACTCC6T6ATGGGCC66TTCACCATCTCCCGCGACAATTCCM6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACTGCG6TATATTACT6TGCGAAACTTCCGTTTATGTTTGACGACC GGGGTCA666AACCCT66TCACC6TCTCGA6C (SEQ ID NO： 946) BMS3h-56-32 GAGGTGCAGCT6TTGGAGTCTGGGGGAGGCTTGGTACAGCCTGG6G66TCCCTGC6TCTCTCCTGTGCAGCCTCC6GAT TCACCTTTCGG6ATTATGAGATGT66TGG6TCCGCCAGGCTCCAGG6AAGGGTCTAGAGTGGGTCTCAGCTATTAATCC GCA6GGTAC6CGTACATACTAC6CAGACTCCGTGATGGGCC66TTCACCATCTCCC6CGACAATTCCAA6AACAC6CT6 TATCTaCAAATGAACAGCCTGCGTCCCGAGGATACCGCGCTATATTACTGTGCGAAACTTCCGTTTACTmGACGACT 666GTCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 947) • 132-
163920.doc 201245225 BMS3h-56-33 6A6GTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTATCCTGT6CAGCCTCCGGAT TCACCTTTCGGGATTATGAGAT6TGGT66GTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCA6CTATTAATCC GCA6GGTACGCGTACATACTACGCAGACTCCGTGATGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACTGCGGTATATTACTGTGCGAAACTTCCGTTTATGTTTGACGACC GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 948) BMS3h-56-202 GAGGTGCAGCTGTTGGAGTCTGGGGGftGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTAT6AGATGTGGTGGGTCCGCCAGGCTCCA6GGAA6GGTCTA6AGCGGGTCTCA6CTATTAATCC GCAGGGTACGCGTACATACTACGCAG^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGAGGACACCGCG6TATATTACTGTGCGAAACTTCCGACCTACTTTTCCGACC 66G6TCAG6GAACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 949) BMS3h-56-203 GAGGTGCAGCTGTTGGAGTCTG6G6GAG6CTT6GTACAGCCTG6GGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTTCGGGATTAT6A6ATGTGGTGG6TCCGCCA6GCTCCAGGGAAGG6TCTAGAGCG66TCTCAGCTATTAATCC GCA66GTACGCGTACATACTACGCAGACTCCGTGAA6GGCCG6TTCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGC-CGAGGACACCGCGGTATATTACT6TGCGAAACTTCCGTTTTTCTTTGAGGA6T GGGGJCAG6GAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 950) BMS3h-56-284
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGC6GGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGACGTACTTTAAGGACT GGGGTCAGGGAACCCTG6TCACCGTCTC6AGC (SEQ ID NO: 951) BMS3h-56-205 GAGGT6CAGCTGTTGGAGTCTGG6GGAGGCTTGGTACAGCCTGGGGG6TCCCTGCGTCTCTCCT6TGCAGCCTCCG6AT TCACCTTTCGG6ATTAT6AGATGTG6TGGGTCCGCCAGGCTCCAGG6AAGG6TCTA6AGC6GGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAG/iVCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTTCCGAOT GGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 952) BMS3H-56-206
GA6GTGCAGCTGTTGGAGTCTGGGGG\GGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCT6TGCAGCCTCC66AT
TCACGTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAeGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC gcagggtacgcgtacatactacgcagActccgtgaagggccggttcaccatctcccgcgacaattccaagaacacgctg TATCTGCAAATGAACAGCCT6CGTGCi：GAGGACACCGCGGTATATCACTGT6CGAAACTTCCGATGTTCTTTGA6GACT GG6GTCAG66AACCCTGGTCACC6TCTC6AAC (SEQ ID NO: 953) BMS3h-56-207 GAGGTGCAGCTGTTGGAGTCTG6GGGi\GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTCGGGATTATGAGATGTGffrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTAC6C6TACATACTACGCAG>\CTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGTGC<：6A6GACACCGC6GTATATTACT6TGC6AAACTTCCGTTTCCGTTTTCGGAGT GGGGTCAGG6AACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 95A) 133· 163920.doc 201245225 BMS3h-56-208 GAGGTGGAGCTGTTGGAGTCTGGGGGAGGnTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTnC6G6ATTATGA6ATGTGGTGGGTCCGCCAGGCTCCAG6GAAGGGTCTAGAGCGG6TCTCAGCTATTAATCC 6CAGGGTAC6CGTACATACTACGCAGACTCC6T6AAG6GCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATG6ACAGCCTGCGTGCCGAGGACACC6C6GTATATTACTGTGCGAAACTTCC6TTTTACTTTTCC6AGT GGGGTCA66GAACCCT6GTCACC6TCTCGAGC (SEQ ID NO: 955) BMS3h-56-209 GAG6TGCA6CT6TT66AGTCT6GGG6AGGaTGGTACAGCCTGGGG6GTCCCTGC6TCTCTCCT6TGCAGCCTCC66AT TCACCTTTC6G6ATTAT6A6ATGTG6TGGGTCC6CCAGGCTCCAGG6AA6GGTCTAGAGC6GGTCTCA6CTATTAATCC 6TACGGTAACCTCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCC6TTTACTTTTGAG6ACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 956) BMS3h-56-210 GAGGTGCA6CTGTT6GAGTCT66GG6AGGCTT6GTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTC6GGATTATGAGATGT6GTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGA6CGG6TCTCA6CTATTAATCC GCCCG6TACCTT6ACATACTAC6CAGACTCCGT6AAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGAGGATACC6CGGTATATTACTGTGC6AAACTTCCGTTTACTTTTGAGGACC G66GTCAGG6AACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 957) BMS3h-56-211 GAG6TGCAGCTGTTGGAGTCTGG6G6AGGCTTGGTACAGCCTGGGGG6TCCCTGC6TCTCTCCT6TGCAGCCTCCG6AT TCACCTTTC66GATTATGAGATGT6GT6G6TCCGCCAGGCTCCAGGGAAGGGTCTAGAGC6GGTCTCAGCTATTAATCC GTGGGGTGGCTTGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAAnCCAAGAACACGCTG TATCTaAMTGMCAGCCTGCOTGCCGAGGATACCGCGGTATAnACTGTGCGAAACTTCCGmACTTTTGAGGACT GGG6TCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 958) BMS3h-56-212 GAGGTGCAGCTGTTGGAGTCTGGG66A6GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6T6CAGCCTCCGGAT TCACCTTTCGGGATTATGA6ATGTG6TG6GTCCGCCAG6CTCCA6GGAAG6GTCTA6A6C6G6TCTCA6CTATTAATCC GAT6GGT6GGTTCACATACTACGCAGACTCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAAT6AACAGCCTGCGTGCCGAG6ATACCGC6GTATATTACTGTGCGAAACTTCCGTTTACTTTT6A66ACT GGGGTCA6G6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 959) BMS3h-56-213 GAGGTGCAGCTGTTCGAGTCTGGGGGAGGCnGCTACAGCCTGGGGGGTCCCTGCGTCTCTCCTCTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCC6CCA6GCTCCAGGGAAGGGTCTAGAGCG66TCTCAGCTATTAATCC GTG6GGTTCGCACACATACTACGCA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTOTGCGAAACTTCCGTTTACmTGAGGACT GGGGTCAGGGAACCaGGTCACCGTCTCGAGC (SEQ ID NO： 960) BMS3h-56-214 6A6GTGCAGCTGTTG6AGTCTGGGGGAGGCnGGTACA6CCTGG66G6TCCCTGC6TCTCTCCTGTGCA6CCTCCGGAT TCACCTTTCG66ATTATGAGATGTGGT6GGTCCGCCAGGCTCCAGG6AAGGGTCTAGAGC6G6TCTCAGCTATTAATCC GTCC6GTGGGCTGACATACTACGCAGACTCCGT6AAGG6CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTAaGTGCGAAACTTCCGTTTACTTnGACGACC GGGGTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 961) -134·
163920.doc 201245225 BMS3h-56-215 6AG6T6CA6CTGTTGGAGTCT6GG6GAGGCTT6GTACAGCCT66GGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTCG6GATTATGA6AT6T6GT6GGTCC6CCAG6CTCCAG6GAA666TCTAGAGC6GOTCTCAGCTATTAATCC GCACGGTTCGTTGACATACTAC6CAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCT6CGTGCC6A6GATACCGCGGTATATTACT6TGCGAAACTTCC6TTTACTTTTGACGACT G6GGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 962) 6MS3h-56-216 GA66TGCAGCTGTTG6AGTCT6GGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGG6TCCGCCAGGCTCCAG6GAA6GGTCTA6AGCGG6TCTCA6CTATTAATCC GGCCGGTCGGTT6ACATACTACGCAGACTCCGT6AA6GGCCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTTTTGAGGACT G6GGTCA6GGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO: 963) BMS3H-56-2X7 GAG6TGCA6CTGTT66AGTCT66G66iV6GCTTGGTACAGCCTGGGG6GTCCCT6C6TCrCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAG6GTCTA6AGCGGGTCTCAGCTATTAATCC 6TG6GGTA6CTT6ACATACTAC6CAG^CTCCGTGAAG6GCCGGTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGC 二 GAGGATACCGCGGTATAHACTGTGCGAAACTTCCGTTTACTTTTGAGGACT GGGGTCA666AACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 964) BMS3h-56-218
GA6GTGCAGCTGTT6GAGTCT6GGGa!\GGCnG6TACAGCCTGGGG6GTCCCT<3CGTCTCTCCTGT6CA6CCTCC6GAT TCACCTTTCCCGACTACGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTAC6CGTACATACTACGCAG；!VCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATaGCAAATGAACAGCCTGCOTGCCGAGGATACCGCGGTATATCACTGTGCGAAACTTCCGTTTACTTTTGACGACT GG6GTCAGGGAACCCTGGTCACC6TCTC6AGC (SEQ ID NO： 965) BMS3h-56-219 6A6GT6CAGCTGTT6GAGTCT666G6i\66CTTG6TACA6CCT6GGGGGTCCCT6C6TCTCTCCTOTGCA6ACTCCGGAT TCACCnTCCGCCCGTGGAGAT6T6G*rGG6TCCGCCAGGCTCCAG6GAAGGGTCTA6AGC6G6TCTCAGCTATTAATCC GCAGGGTACGCGTACATACTAC6CAGACTCCGT6AAGGGCCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCTG TATCTGCAAAT6AACAGCCTGCGT6C(：6AGGATACCGCGGTATATTACTGT6C6AAACTTCCGTTTACTTTTGA6GACT 6GGGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID'NO： 966) BMS3h-56-220 GAG6T6CA6CTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTC6GGATTATGA6AT6TGGTGGGT.CCGCCAGGCTCCAGG6AAGGGTCTA6AGCGGGTCTCAGCTATTAATCC GTAWGTGGGCTGACATACTACGCAGAaCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCT6CGTGC(：GAGGATACCGCGGTATATTACTGT6CGAAACTTCCGTnACTTTTC5ACGACT GGG6TCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 967) BMS3h-56-221 GAGGTGCAGCTGTTGGAGTCTGGGGG>VGGCTTGGTACA6CCT6GGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCC6GAT TCACCTTTC6GGATTATGAGATGT6G"GG6TCCGCCAGGCTCCAGGGAAGGGTCTAGAGCG6GTCTCAGCTATTAATCC GTGGGGTAACCACACA了 ACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCC 丁 GCGTGCCGAGGATACCGCGGTATATTAC 了 GTGCGAAACTTCCGTTTACTTTTGAGGACT G6G6TCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO: 968) 135- 163920.doc 201245225 BMS3h-56-222 GAG6T6CA6CTGTTGGA6TCTGGG6GAGGCTTGGTACAGCCT6GG6GGTCCCT6CGTCTCTCCTGTGCA6CCTCC6GAT TCACCTTTCGGGATTAT6AGATGT66TGGGTCC6CCAGGCTCCA66GAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCACGGTG6CTACACATACTACGCAGACTCCGTGAA666CCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAAT6AACAGCCT6C6TGCC6AGGATACC6CG6TATATTACTGTGCGAAACTTCC6TTTACTTTTGAGGACT G6GGTCA6GGAACCCTG6TCACCGTCTCGAGC (SEQ ID MO： 969) BMSBh-56-223 6A66T6CA6CTGTTG6A6TCTGGG6GAG6CTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCT6TGCA6CCTCCG6AT TCACCTTTC6GGATTATGAGATGTG6TGG6TCCCCCA66CTCCAG6GA6GGGTCTAGAGCG66TCTCAGCTATTAATCC GCCCGGTATGCTCACATACTACGCAGAC 丁 CC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCT6C6T6CCGA6GATACCGCGGTATATTACT6TGCGAAACTTCCGTTTACTTTTGAC6ACT G6G6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 970) BMS3h-56-224 GA6GTGCAGCTGTTGGA6TCTG66GGAG6CTTGGTACA6CCT6GGGGGTCCCT6C6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC 6TGGGGTCAGTTGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACAC6CTG TATCT6CAAAT6AACAGCCTGC6T6CCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTTTTGAGGACT GGGGTCA6GGAACCCT6GTCACC6TCTCGAGC (SEQ ID NO： 971) BMS3h-56-225 GAGGTGCAGCTGHGGAGTCTGGGGGAGGCTTCGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGA6ATGT66T6GGTCCGCCAGGCTCCAG66AAGGGTCTAGA6CGGGTCTCAGCTATTAATCC 6TG666TGGCTACACATACTACGCA6ACTCC6TGAAGG6CCGATTCACCATCTCCCGC6ACAATTCCAAGAACAC6CTG TATCT6CAAATGAACA6CCTGCGTGCCGAG6ATACCGCGGTATATTACTGT6C6AAACTTCCGTTTACTTTT6AC6ACT 6G6GTCA6GGAACCaGGTCACCGTCTC6AGC (SEQ ID NO： 972) BMS3h-56-226 6AGGTGCA6CT6TTG6AGTCT6GG6GAG6Cn66TACAGCCTG6GGG6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTC6GGATTATGA6ATGTG6TGG6TCCGCCAG6aCCA66GAA6G6TCTA6AGCGGGTCTCAGCTATTAATCC 6TCGGGT6GGCT6ACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACrGTGCGAAACTTCCGTTTACTTTTGAGGACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 973) BMS3h-56-227 GAGGTGCA6CTGTTG6AGTCTGG6GGAG6CTTGGTACAGCCTGGGGG6TCCCTGCGTCTCTCCTGTGCA6CCTCCG6AT TCACaTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTCGGGTGGGTTGACATAaACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATAUACTGTGCGAAACTTCCGTTTACTTHGACGAC 了 G6GGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 974) BMS3h-56-228 GA6GTGCAGCTGTTG6AGTCTGG6GGAG6CTTGGTACAGCCTGGGGGGTCCaGC6TCTCTCCTGT6CAGCCTCCGGAT TCACCTTTCGG6ATTAT6AGATGTGGTGGGTCCGCCAGGCTCCAGGGAA666TCTAGA6CGGGTCTCA6CTATTAATCC GTCGGGTACGCTCACATACTACGCAGACTCC6TGAA66GCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCaGCGTGCCfiAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTTTTGAGGACT GGGGTCAGGGAACCCT6GTCACCGTCTC6AGC (SEQ ID NO: 975) -136-
163920.doc 201245225 BMS3h-56-229 GAGGTGCA6CTGTTGGAGTCTG6GGGyV66CTT66TACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGmATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTACGGTTCGTTGACATACTACGCAG 八CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGrTTACTTTTGACGACT 6GGGTCA6GGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 976) BMS3H-56-230 6AGGT6CAGCTGTTGGAGTCTG6666yVGGCTTGGTACAGCCT6GG66GTCCCTGC6TCTCTCCTGT6CAGCCTCC66AT TCACCTTTCGGGATTAT6AGAT6TG6*：GGGTCC6CCA6GCTCCAG66AAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTGGCTACACATACTACGCA6>^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTTTTGAGGACT 6GG6TCAG6GAACCCTGGTCACCGTCVC6AGC (SEQ ID NO： 977) BMS3h-56-231 GAG6TGCAGCTGTTG6AGTCTGGGG6/VGGCTTGGTACAGCCTGGGG6GTCCCTGCGTaCTCCT6TGCAGCCTCCG6AT TCACCTTTCGGGATTATGAGATGTGGrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGT6GGCTGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCT6 TATCTGCAAATGAACA6CCTGC6TGC(：GAGGATACCGCG6TATATTACT6T6CGAAACTTCCGTTTACTTTTGA6GACT GGGOTCAGGGAACCCTGGTCACCGTCrCGAGC (SEQ ID NO: 978) BMS3h-56-232
6AG6TGCAGCTGTTG6A6TCT6G6GG/\6GCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCCG6AT TCACCmCGGGAHATGAGATCTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTTCCCACACATACTACGCAG/XTCCOTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGC(：GA6GATACC6CGGTATATTACTGTGCGAAACTTCC6TTTACTTTTGACGACT GGGGTCAGGGAACCCT6OTCACCGTC1CGAGC (SEQ ID NO： 979) BMS3h-56-233 GAGGT6CA6CTGTTGGA6TCTGGGGG/IGGCTTGGTACA6CCTGG6GG6TCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT TCACCTTTC6G6ATTAT6A6AT6TGGTGGGTCC6CCAGGCTCCAGGGAAGG6TCTAGAGCGGGTaCAGCTATTAATCC 6TGG66TACCTTGACATACTACGCA6/iCTCCGTGAAGGGCC66TTCACCATCTCCCGCGACAATTCCAGGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGA6GATACCGC6GTATATTACTGTGCGAAACTTCCGTTTACTTTTGACGACT 6GGGTCAG6GAACCCT66TCACCGTCTC6AGC (SEQ ID NO： 980) BMS3h-56-234 6AGGT6CAGCTGTTGGA6TCTGGGGGAGGCTTGGTACA6CCT6GGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTAT6AGATGT6GTGGGTCC6CCAGGCTCCAG6GAA6GGTCTAGAGC6G6TCTCAGCTATTAATCC 6AACGGTCGGCT6ACATACTAC6CA6/\CTCCGTGAAGGGCCGGnCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6CC6AGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTTTT6CGGACT GGG6TCA6GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 981) BMS3h-56-235 GAGGTGCAGCTGTTGGA6TCTGG6GG/vG6CTTGGTACAGCCTGGGG66TCCCTGCGTCTCTCCT6T6CA6CCTCCGGAT TCACCTTTCGGGATTATGA6ATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTCAGCTGACATACTACGCAG/^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTTTTGACGAa GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 982) •137· 163920.doc 201245225 BMS3h-56-236 GAGGTGCAGCTGTTCGAGTaGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTCCAGCCTCCGGAT TCACCTTTCG6GATTAT6A6AT6TGGT6G6TCCGCCAG6aCCAG6GAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCACGGTG6CCTCACATACTACGCAGACTCC6TGAA6G6CCGGTTCACCATCTCCC6C6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCT6CGT6CCGA66ATACCGCG6TATATTACTGTGC6AAACTTCCGTTTACTTTT6ACGACT G666TCAGG6AACCCTeeTCACC6TCTCGA6C (SEQ ID NO: 983) BMS3h-56-237 6AGGT6CAGCTGTTGGAGTCTG6G6GA6CCTT6GTACAGCCT6G66GGTCCCTGCGTCTCTCCTGT6CAGCaCCGGAT TCACCTTTCGGGAHATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGCGGGTCTCAGCTATTAATCC 6GCGG6TATGTT6ACATACTACGCAGACTCCGTGAAG6GCC6GTTCACCATCTCCCGCGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTCCCGAG6ATACCGCG(3TATATTACTGTGC6AAACTTCCGmACTTTTGACGAC 下 6G6GTCA6GGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 984) BMS3h-56-238 GAG6T6CA6CTGTTGGAGTCTG6GG6A66CTTGGTACAGCCTGG6GGGTCCCTGC6TCTCTCCTGT6CA6CCTCCGGAT TCACCTTTC6GGATTATGA6AT6T66TGGGTCC6CCAGGCTCCA6GGAAGGGTCTAGAGCG6GTCTCAGCTATTAATCC GCACG6TACCTTGACATACTACGCAGACTCC6T6AAGG6CCGGTTCACCATCTCCC6CGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGA6GATACCGCGGTATATTACT6TGC6AAACTTCCGTTTACTTTTGAGGACT G6G6TCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 985) BMS3H-56-239 6AGGTGCAGCTGTT6GA6TCTGGGGGAGGCTTG6TACAGCCTGGGG6GTCCCTGCGTCTCTCCTCT6CAGCCTCCG6AT TCACCTTTCGGGATTATGAGAT6TGGT6G6TCC6CCAGGCTCCAG6GAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTTCGTTGACATACTACGCAGACTCCGT6AAGGGCCG6TTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCT6CAAATGAACAGCCTGCGT6CC6A6GATACCGCGGTATATTACTGTGCGAAACTTCC6TTTACTTTTGACGACT GG66TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 986) BMS3h-56-240 GAGGT6CAGCTGTTG6A6TCT66GGGAGGCTT66TACAGCCT6GG6G6TCCCT6C6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTC 了 CAGCTATTAATCC GTACGGTGGCCTGACATACTACGCAGACTCC6T6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCT6CAAATGAACAGCCTGCGTGCC6A6GATACCGC6GTATATTACTGTGC6AAACTTCCGTTTACTTTTGAG6ACT 66GGTCAGG6AACCCTG6TCACCGTCTC6AGC (SEQ ID NO： 987) BMS3h-56-241 GAGGTGCAGCTGTTGGAGTCTGGG6GAGeCTTGGTACA6CCTGGG6G6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTC6GGATTACGA6ATGT66TGGGTCCGCCAG6CTCCAG6GAA6GGTCTAGAGCGGGTCTCAGCTATTAATCC GGCC6GTTTCTTGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCC6CGACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACA6CCT6CGTGCC6AGGATACC6CGGTATATTACTGTGCGAAACTTCCGTTTACTTTTGAGGACT GGG6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 988) BMS3h-56-242 6A6GTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACGGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGCG66TCTCAGCTATTAATCC GTAC6GT6GCCTGACATACTACGCAGACTCCGTGAAG66CCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTrTTGAGGACT 6GG6TCAGGGAACCCT6GTCACCGTCTC6A6C (SEQ ID NO： 989) 138-
163920.doc 201245225 BMS3h-56-243 6A66T6CAGCTGTTGGAGTCT6GGGG/.6GCTT6GTACAGCCTGGGGGGTCCCT6C6TCTCTCCTGT6CA6CCTCCGGAT TCACCTTTCGGGATTATGAGATGT6G16G6TCCGCCA6GCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTGGGTTCACATACTAC6CA6/.CTCCGTGAAG6GCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAAT6AACAGCCTGC6TGCC6AG6ATACCGCGGTATATTACTGTGC6AAACTTCCGTTTACTTTT6AGGACT GGGGTCAGGGAACCCTGGTCACCGTC1CGAGC (SEQ ID NO： 990) BMS3h-56-244 GAGGTGCAGCTGTTGGAGTCTGGGGG^.GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCaCCGGAT TCACCTTTCGGGATTATGAGATGTGG1G6GTCCGCCAGGCTCCAGGGAAGGGTCTA6AGC6GGTCTCAGCTATTAATCC GT6GGGTGGGTTGACATACTACGCA6/S.CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTACTTTTGACGACT GG6GTCA6GGAACCCTG6TCACC6TC1CGAGC (SEQ ID NO: 991) BMS3h-56-245 GAGGTGCAGCTGTTGGAGTCTGGGGG^GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGG6ATTATGAGAT6TG6TG6GTCCGCCAGGCTCCAGG6AA6GGTCTAGAGCG6GTCTCAGCTATTAATCC GTACGGTGGGCTGACATACTACGCAG/SCTCCGTGAAGGGCCGGnCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGGACAGCCTGCGTGCCGAG6ATACCGC6GTATATTACT6TGCGAAAaTCCGTTTACTTTTGAG6ACT 6GGGTCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 992) BMS3h-56-246
6AG6TGCAGCTGTTGGAGTCTGGGGG^6GCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTACGTTGACATACTACGCAG/iCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGaGAGGATACCGCGGTATATTACTGTCSCGAAACTTCCGTTTACTTTTGAGGACT G666TCAGGGMCCCTG6TCACCGTCTCGA6C (SEQ ID NO： 99B) BMS3h-56-247 GAG6TGCAGCTGTTG6AGTCTG6GGG/iGGCTT6GTACAGCCTGGGG66TCCCTGCGTCTCrCCT6T6CAGCCTCCGGAT TCACCTTTC6GGATTATGAGATGT6G7GG6TCCGCCAGGCTCCAGGGAA6GGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTGGCTACACATACTACGCAG^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCG 丁 GCCGAGGATACCGCGGTATAHACTCTGCGAAACTTCCGmAOlTTGAGGACT GGGGTCGGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 994) BMSBh-56-248 GAGGTGCAGCTCTTGGAGTC 了 GGGGGAGGCTTCGTACAGCCTGGGGGCTCCCrGCCTCTCTCCTGTGCAGCCTCCGGAT TCACaTTCGGGAHATGAGATGT6GTGGGTCCGCCAG6CTCCA(3G6AAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTACGGTAACCTGACATACTACGCAG^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6C6T6CCGA66ATACCGCGGTATATTACTGT6CGAAACTTCCGTTTACmrT6ACGACT GG66TCA6GGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 995) BMS3h-56-249 6AGGTGCAGCTGTT66AGTCTa366G^GGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCA6CCTCC6GAT TCACCTTTCG66ATTATGA6ATGTGGTG6GTCCGCCA66CTCCAGGGAAG6GTCTA6AGCG6GTCTCAGCTATTAATCC 6CACGGTGGGTTCACATACTACGCAG^CTCC6T6AA6GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGT6CCGAGGATACCGCGGTATATTACTGTGCGAAACTTCC6TTTACTTTTGAGGACT 6GGGTCAG6GAACCCTG6TCACC6TCTC6AGC (SEQ ID NO: 996) -139· 163920.doc 201245225 BMS3h-56-250 (3AGG 丁 GCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCCTCKTCCTGTGCAGCCTCCGGAT TCACCTTTC6GGATTATGAGATGT66TGGGTCCGCCAGGCTCCAG66AA6GGTCTAGAGC6GGTCTCAGCTATTAATCC GGCCGGTTTCTACACATACTACGCAGACTCCGT6AAGGGCCG6TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAAT6AACA6CCTGC6T6CCGA66ATACCGCGGTATATTACTGTGC6AAACTTCCGmACTTTTGACGACT GGGGTCAGGGAACCCTGGTCACC6TCTC6AGC (SEQ ID NO： 997) BMS3h-56-251 GAGGTGCAGCT6TT6GAGTCTGGGG6AGGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTC6GGATTATGAGATGTGGT66GTCCGCCA6GCTCCAGG6AAGGGTCTA6AGC6GGTCTCAGCTATTAATCC 6GCGGGTGGCCTCACATACTACGCAGACTCCGTGAAG6GCC6GTTCACCATCTCCCGC6ACAATTCCM6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACnCCGTTTACTTTTGACGACT GG6GTCAGG6AACCCTG6TCACCGTCTCGA6C (SEQ ID NO： 998) BMS3h-56-252 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTCTGCAGCCTCCGGAT TC6CCTTTC666ATTATGAGATGTG6TGGGTCCGCCAGGCTCCAGG6AAG6GTCTA6AGCGGGTCTCAGCTATTAATCC GCACG6TTCCCTCACATACTACGCA6ACTCC6TGAA6GGCC66TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGC6T6CC6A6GATACCGCGGTATATTACT6TGC6AAACTTCCGTTTACTTTTGA66ACT GGGGTCA666AACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 999) BMS3h-56-253 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTrCGTGATTATGA6ATGTGGT66GTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGG6TCTCA6CTATTAATCC GGCCGGTGGGTACACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATCACTGTGCGAAACTTCCGTTTACTTTTGAGGACT GG6GTCAG6GAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 1000) BMS3h-56-254 GAGGTGCAGCT6TTG6AGTCTGGGGGAG6CTT<5GTACAGCCTGGGGG6TCCCTGC6TCTCTCCTGTGCA6CCTCCG6AT TCACCTTTCGGGAHATGAGATGTCCTGGGTCCGCCAdGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATC 丁 CCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCG6TATATTACTGTGCGAAACTTCC6TTTT6GTTTACGGAGT GGGGTCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 1Θ01) BMSBh-56-255 6AGGT6CAGCT6TT6GAGTCTGGG6GAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGT6CA6CaCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGGnCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGAGGATACCGC6GTATATTACTGTGCGAAACTTCCGTTCATGTTTTCCGACC GGGGTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO： 1002) BMSBh-56-256 GAGGTGCAGCTGTTGGAGTCT6GGGGAGGCTT6GTACAGCCTGGGG6GTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCG6GATTAT6AGATGTG6T6GGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGC6G6TCTCAGCTATTAATCC 6CAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCC6AGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTTGTTTCAGGAGT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1003) • 140_
163920.doc 201245225 BMS3h-56-257 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAG/iCTCCGTGAAG6GCCG6TTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGAC6CGGTTT6AGGACT GG66TCAGG6AACCCT66TCACCGTCTCGAGC (SEQ ID NO： 1004) BMS3h-56-258 GAGGTGCAGCTGTTGGAGTCT6GGGG/1GGCTTGGTACAGCCTGGG6GGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGG6TAC6CGTACATACTAC6CAG/1CTCCGTGAAGG6CCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGT GGG6TCAGGGAACCCTGGTCACCGTC1CGAGC (SEQ ID NO: 1005) BMS3h-56-259 GAG6TGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGA6ATGTGGT6G6TCCGCCAGGCTCCAG6GAA6GGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAG/lCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCC6AGGATACCGCGGTATATTACTGT6GGAAAGAGCCGTTTCGTTATGACTACT GGGGTCAGGGAACCCTGGTCACCGTCrCGAGC (SEQ ID NO： 1006) BMS3h-56-260
6AG6T6CAGCTGTTGGA6TCTGGGGG/IGGCTTGGTACAGCCTG6GG66TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATrATGAGATGTGGl'GGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC 6CA66GTAC6C6TACATACTACGCAG/iCTCCGT6AAGGGCCG6TTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGACGTTCTTTAAGGACT GGGGTCAGGGAACCCTGGTCACCGTCl'CGAGC (SEQ ID NO： 1007) BMSBh-56-261 GAG6TGCAGCTGTTGGA6TC 了 (SGGGGAGGCHGGTACAGCCTGGGGGGTCCCTGCCTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCA6GGTACACGTACATACTACGCAOVCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGC<：GAGGATACC6CGGTATATTACTGTGCGAAACTTCCGTTTTTCnTCA6GA6T GGGGTCAGG6AACCCT66TCACC6TC C6AGC (SEQ ID NO: 1008) BMS3h-S6-262 GAG6T6CAGCTGTTGGAGTC.TG6GG6；VGGCrTGGTACA6CCT6GGG6GTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGA6ATGTGG^GGGTCCGCCAGGCTCCAG66AAG6GTCTAGAGCGGGTCTCAGCTATTAATCC GCAGG6TACGCGTACATACTACGCAG)^CTCC6TGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGCAGTTGnTCACGACC GGGGTCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 1009) BMS3h-56-263 GAGGTGCAGCTGTTG6AGTCT666GGAGGCTTGGTACA6CCTGGG6GGTCCCTGCGTCTCTCCTGTGCAGCCTCC66AT TCACCTTTCGGGATTAT6A6AT6TGGTGGGTCCGCCAGGCTCCA6GGAA6GGTCTA6A6CGGGTCTCAGCTATTAATCC GCAG6GTACGCGTACATACTACGCAGACTCC6T6AAGGGCC6GTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCT6C6TGCCGAGGACACCGC66TATATTACTGT6CGAAACTTCCGCAGCTCTTTGAGGACT GGG6TCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 1Θ10) •141· 163920.doc 201245225 BMS3h-56-264 GAGGTGCAGCT6TTC6AGTCTGGGG6AGGCTT6GTACAGCCTGGG(366TCCCT(3〔6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCG6GATTATGAGATGTGGT66GTCCGCCAGGCTCCAG66AA6G6TCTA6AGC6GGTCTCA6CTATTAATCC GCAGG6TACGC6TACATACTAC6CA6ACTCCGTGAA666CCGGTTCACCATCTCCC6CGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCa6CGTGCCGAGGATACC6CG6TATATCACT6T6C6AAACTTCC6TTT6GGTTTTCC6AGT GG6GTCAGG6AACCCTGGTCACC6TCTC6AGC (SEQ ID NO： 1011) BMS3h-56-265 GAGGTGCAGaGTTGGAGTaGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCCTCTCTCCTGTGCAGCCTCCGGAT 丁 CACCTTTCGGGAHATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCT6CAAAT6AACA6CCT6CGTGCC6AGGACACCGC6GTATATTACTGT6CGAAACTTCCGCAGTT6TTTCAGGACT G6GGTCAGG6AACCCTGGTCACC6TCTCGAGC (SEQ 10 NO： 1012) BMSBh-56-266 GAG6TGCAGCTGTTGGAGTCT6GGGGAG6CTTGGTACAGCCT6GGGGGTCCCTGCGTGrGrCCT6TGCAGCCTCCG6AT TCACCTTTC66GATTATGA6ATGT66TGGGTCC6CCA6GCTCCAGGGAA6G6TCTA6AGC6GGTCTCAGCTATTAATCC GCAGGGTACGC6TACATACTAC6CAGACTCCGTGAAGQGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCT6CAAAT6AACAGCCTGC6TGCC6AGGACACCGCG6TATATTACTGTGCGAAACTTCCGTTTTTCTTTCAC6AGT GG6GTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1013) BMS3h-56-267 GAGGTGCAGCTGTTG6AGTCTGGG66A6GCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGAT6TGGT6GGTCC6CCAGGCTCCA6GGAAGGGTCTAGAGC6GGTCTCAGCTATTAATCC GCAGC3GTACC3CG 丁 ACATACTACGCAGACTCCGTGAAG6GCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGCACTACTTTAAGGACT GGGGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO； 1014) BMS3h-56-268 GAGGTGCAGCTGTTG6AGTCTGGG6GAGGCTTGGTACA6TCTGGG66GTCCCTGCGTCTCTCCTGTGCA6CCTCC66AT TCACCTTTCGGGATTATGAGAT6TGGT6G6TCC6CCAGGCTCCAGGGAA66GTCTAGAGCG6GTCTCAGCTATTAATCC GCAGG6TAC6C6TACATACTAC6CA6ACTCCGTGAAGGGCC66TTCACCATCTCCC6CGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCC6TTTTACTTTGAG6A6T GGGGTCAG6GAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 1015) BM53h-56-269 6AGGTGCAGCT6TT6GAGTCT66GGGAGGCTT66TACAGCCTGGG6G6TCCCTGCGTCTCTCCTGTGCAGCCTCC66AT TCACCTTTCGGGATTATGAGATCTGGTGGGTCCGCCAGGCTCCAGGGAAGGOTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAGAC 丁 CCCTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGC6TGCC6AGGATACC6CGGTATATTACT6TGC6AAACTTCCG7TTA6GTTTTCCGACC 6GG6TCAGGGAACCCT6OTCACC6TCTCGAGC (SEQ ID NO： 1016) BMS3h-56-270 GAGGTGCAGCTGTT6GA6TCTGGGGGA6GaTG6TACA6CCTG6GGG6TCCCTGC6TCTCTCCT6TGCAGCCTCCG6AT TCACCTTTCGGGATTAT6AGATGTGGTGG6TCC6CCAGGCTCCAG6GAA666TCTAGAGCGG6TCTCAGCTATTAATCC GCA6GGTACGCGTACATACTAC6CAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTAi'ATTACTGTGCGAAACTTCCGACGCTGTTTCAGGACT GGG6TCA6GGAACCCT6GTCACCGTCTC6A6C (SEQ ID NO： 1017) •142-
163920.doc 201245225 BMS3h-56-271 GAG6TGCAGCTGTTGGAGTCTG6G6GA6GCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCC6GAT TCACCTTTCGGGATTATGAGAT6TGGT6GGTCCGCCAGGCTCCAGGGAA6G6TCTAGAGCGGGTCTCAGCTATTAATCC GCA666TACGCGTACATACTAC6CAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACC6CGGTATATTACTGTGCGAAACTTCCGTTTTACTTTTCCGA6T GGGGTCA6GGAACCCTG6TCACCGTCTCGAAC (SEQ ID NO: 1018) BMS3h-56-272 GAGGTGCAGCTGTTGGAGTCtGGGGGiV6GCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6T6CAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GCAGGGTACGCGTACATACTACGCAG^CTCCGTGAAGGGCCGGnCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCCTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTGGTTTCAGGAGT GGGGTCAGGGAACCCTGGTCACCGTCfCGAGC (SEQ ID NO: 1019)
BMSBh-56-27B GAGGTGCAGCTGTTGGA6TCTGGGGGAGGCTTG6TACAGCCTGGGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTCGGGATTAT6A6AT6T6GrGGGTCCCCCAGGCTCCA6GGAAGG6TCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTTCGTTGACATACTAC6CAGACTCC6TGAA6GGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATAHAaGTGCGAAACTTCCGTTTTACTTTCAGGAGT GG6GTCAG6GAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 1020) BMSBh-56-274
GAG6TGCAGCTGTT66A6TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGT6CA6CCTCCGGAT TCACCTTTCGGGATTAT6AGAT6TGGTG6GTCC6CCAGGCTCCAGGGAAGGGTCTA6AGCGG6TCTCAGCTATTAATCC GTGGGGTTCGTTGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATCACTGTGCGAAACTTCCGATGTTCTTTGAGGACT GG6GTCAGGGAACCCTGGTCACCGTCTC6AAC (SEQ ID NO： 1021) BMS3h-56-275 6AGGTGCAGCTGTTGGA6TCTGGG6G!VGGCTTGGTACAGCCTGG6GGGTCCCT6C6TCTCTCCTGTGCA6CCTCCGGAT TCACCTTTCG6GATTAT6AGAT6TGGrGGGTCC6CCAGGCTCCAGGGAA6G6TCTA6A6C6G6TCTCAGCTATTAATCC GTGGGGTTCGTT6ACATACTACGCAG!VCTCC6TGAA6GGCCGGTTCACCATCTCCC6C6ACAATTCCAA6AACAC6CTG TATCTGCAAATGAACAGCCTGC6T6C：6AGGACACCGCGGTATATTACTGTGC6AAACTTCCGTTTTACTTTCAC6AGT G6GGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 1022) BMS3H-56-276 GAG6TGCAGCTGTTGGAGTCTGGGG6A6GCTTG6TACAGCCTGGGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTCGGGATTATGAGAT6TGGTGGGTCC6CCAGGCTCCAGGGAAGGGTCTAGA6CGGGTCTCAGCTATTAATCC GTGGGGTTCGTTGACATACTACGCAa^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6TGCCGAGGACACCGCGGTATATTACT6T6CGAAACTTCC6TTTTTCTTTCAG6A6T G6GGTCAGGGAACCCTG6TCACC6TCTCGAGC (SEQ ID NO： 1023) BMS3h-56-277 6AGGTGCAGCTGTT6GA6TCT6GGGGAG6CTTGGTACAGCCTG6GGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTAT6AGATGTGGTGGGTCC6CCAG6CTCCAGGGAAGGGTCTA6AGCGGGTCTCAGCTATTAATCC GT6GGGTTCGTTGACATACTAC6CAGAeTCCGTGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGC6AAACTTCCGTTTTTCTTTCACGAGT GGG6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 1024) -143 - 163920.doc 201245225 BMS3h-56-278 GAGGTGCAGCTGTTGGAGTCTG6GG6AGGCTTG6TACAGCCTGGG6G6TCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTCGGGATTAT6AGATGTGGT6GGTCC6CCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCA6CTATTAATCC GTGG6GTG66TTCACATACTACGCAGACTCCGT6AAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACAC6CT6 TATCTGCAAAT6AACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGC6AAACTTCCGTTTTACTTTCAG6A6T GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1025) BMSBh-56-279 GAGGT6CAGCTGTTGGAGTCTGG6GGA6GCTTGGTACA6CCTGGGG6GTCCCTGC6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTC6GGATTATGA6ATGTGGTGG6TCCGCCAGGCTCCAGG6AAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGG6GTGGGTTCACATACTACGCAGACTCC6TGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATCACTGTGCGAAACTTCCGATGTTCTTT6AG6ACT GGGGTCA6GGAACCCTGGTCACCGTCTCGMC (SEQ ID NO: 1026) BMS3h-56-280 GAG6T6CAGCTGTTG6AGTCTGG6GGAGGCTTGGTACA6CCT6GGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCC GTGGGGTGGGTTCACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCT6 TATCTGCAAATGAACA6CCTGCGT6CC6AGGACACCGC6GTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGT GGGGTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 1027) BMS3h-56-281 GAG6TGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGG6GGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGA6ATGTGGT6G6TCC6CCAG6CTCCA6G6AAG6GTCTA6AGCG6GTCTCAGCTATTAATCC GTG6G6T6GGTTCACATACTAC6CA6ACTCC6TGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTTCTTTCAGGAGT 6G6OTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 1028) BMSBh-56-282 GAGGTGCAGCTGTTGGAGTCT6GG6GAGGCTTGGTACAGCCT6GGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGA6CGGGTCTCAGCTATTAATCC GTGGGGTGGGTTCACATACTACGCAGACTCC6T6AAGGGCCGGTTCACCATCTCCC6C6ACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGC6TGCC6A6GATACCGC6GTATATTACTGTGCGAAACTTCCGTTTTTCTTTCACGA6T GGG6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 1029) BMS3h-56-283 GAGGT6CA6CTGUGGA6TCT6G666AGGCTT66TACA6CCT666G66TCCCTGC6TCTCTCCT6TGCAGCCTCCGGAT TCACCTTTCGGGATTAT6AGATGT66TG66TCC6CCAGGCTCCA666AAGGGTCTAGAGCG66TCTCAGCTATTAATCC CTGGGGTGGCTTGACATACTACGCAGACTCCGTGAAGGGCCGCTTCACCATCTCCCGCGACMTTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCTGCGT6CC6AGGATACCGC6GTATATTACT6T6C6AAACTTCC6TTTTACTTTCA6GA6T GG6GTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1030) BNS3h-56-284 GAG6T6CAGCTGTT66A6TCTGGGGGAGGCTTG6TACAGCCTGGG6GGTCCCT6CGTCTCTCCTOTGCAGCCTCC6GAT TCACCTTTCG66ATTAT6A6ATGTGGTGGGTCCGCCA6GCTCCA6GGAAGG6TCTA6A6CGG6TCTCA6CTATTAATCC GTGG66TGGGTT6ACATACTACGCA6ACTCC6TGAAGGGCCGGTTCACCATCTCCCGC6ACAAnCCAA6AACAC6CTG TATa6CAAAT6AACAGCCTGCGTGCCGAGGATACC6CGGTATATCACTGT6C6AAACTTCC6AT6TTCTTT6A66ACT G6GGTCAGG6AACCCT66TCACCGTCTCGAAC (SEQ ID NO: 1031) •144-
163920.doc 201245225 BMS3h-56-285 6AGGTGCAGCTGTTGGAGTCTGGG6G^66CTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCT6TGCAGCCTCCG6AT TCACCTTTCGGGATTATGAGATGT6G76GGTCCGCCAGGCTCCAG6GAAGGGTCTAGA6CGG6TCTCAGCTATTAATCC GTGG66TGGGTT6ACATACTACGCAGACTCCGTGAAGGGCC6GTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGmTACTTTCACGAGT GGG6TCAGG6AACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 1032) BMS3h-56-286 GAGGT6CAGCTGTTGGAGTCTGGG66AGGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTA6AGC6GGTCTCAGCTATTAATCC GTGGGGTGGGTTGACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGaG TATCTGCAAAT6AACA6CCTGC6T6CCGAGGATACCGCGGTATATTACT6T6C6AAACTTCCGTTTTTCTTTCAGGAGT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1033) BMS3h-56-287 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTCGG6ATTATGA6ATGTG6T6GGTCCGCCAGGCTCCAGGGAA66GTCTAGAGCGGGTCTCA6CTATTAATCC 6TGGGGT6GGTTGACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAACTTCCGTTTTTCTTTCACGAGT GGGGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 1034) BMS3h-56-288
GAGGTGCAGCTGTTGGAGTCTGGGG6AGGCTTGGTACAGCCTGGGGG6TCCCTGCGTCTCTCCT<3TGCAGCCTCCG6AT TCACCTTTCGGGATTAT6AGATGTG6TGGGTCCGCCAGGCTCCAGGGAAGGGTCTA6AGCGGGTCTCAGCTATTAATCC GCA66GTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGT6CCGA6GACACCGCGGTATATCACTGTGC6AAACTTCCGATGTTCTTTGAGGACT GGGGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID MO: 1035) BMS3h-106-l GAGGTGCAGCTGTTGGAGACTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTTC6ACTTATCATATGCAGTGGGTCCGCCG6GCTCCA66GAAGGGCCT6GAGTGG6TCTCAATGATT6ATGC G6ATGGTCTTGG6ACATACTACGCAGACCCC6TGAAG6GCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGCOTGCCAA66ACACCGCG6TATATTACTGTGC6A6ACCG6GTCC6CAGTTTGGTCA6T TTGACTACTTeG6TCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 1036) BMS3h-106-2 6A66T6CA6CT6TTTGAOTCTGGGGGAGGCrT6GTACAGACT6G66(3GTCCCTGC6TCrCTCCT6TGCA6CCTCCG6AT TCACCTTTTCGACmTCATATGCAGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCAATGATTCATGC GGATGGTCTTGG6AAATACTACGCA6ACCCCGTGAAGG6CC6GTTCACCATCTCCCGC6ACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCT6CGT6CCGAGGACACCGC66TATATTACT6TGT6AAACCG66TCCGCAGTTT6GTCAGT ATGACTACTGGG6TCAG66AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1037) BMS3h-107-l GAG6TGCAGCT6TTGGAGTCAGGGGGAGGCTT6GTACAGCCTGGG6GGTCCCTGCGGCTCTCCTGTTCAGCTTCCG6AT TCACCTTTTCGGG6TATGATATGCAGTG66TCC6CCAGGCTCCA666AA6GGTCTAGA6T6G6TCTCAACGATTAGT6C GTC6GGTGTTTATACATACTAC6CA6ACTCC€TGAA<56GCC66TTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCOTGCCGAGGACACCGCGGTATATTACTGTGCGAAATATCCTAATCGTTTTGCGCTTA ATAGTTTT6ACTACAG66GTCGGGGAACCCTG6TCACC6TCTC6A6C (SEQ ID NO: 1038) 145 _ 163920.doc 201245225 BMS3h-107-2 6A66T6CA6CT6TT6GA6TCT6GGGGAGGCTT66TACAGCCTGG6GGGTCCCTGCGTCTCTCCTGTGCAGCTTCC66AT TCACCTTTTC66G6TATGATATGCAGTGGGTCCGCCAGGCTCCAGGGAGG6GTCTA6AGT66GTCTCAACGATTAGT6C 6TCGGGTGTTTATACATACTACACAGACTCC6TGAAG6GCCGGTTCACCACCTCCCGC6ACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGC6TGCC6A66ACACCGCGGTATATTACTGTAC6AAATATCCAAATCGTTTTGCGCGTA ATAATTTT6ACTACTG666TCAGGGAACCCT66TCACCGTCTCGAGC (SEQ ID NO： 1039) BMS3h-131-l GACATCCTGAT6ACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAG6AGACCGTGTCACCATCACTTGCCGG6CAAATA GTTCTATTTTGT6GGCGTTAGCrr66TACCAGCA6AAACCAGGGGAAGCCCCTAAGCTCCT6ATC6AGAGTTCTTCCGG TTTGCAAAGTGGGGTCCCATCAC6TTTCAGTGGCAGTGGATCTGG6ACA6ATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTGTTCAGAATGCGGTTTGGCCTGGTACGTTCAGCCAAGGGACCAAGGTGGAAA TCAAAC6G (SEQ ID NO: 104Θ) BMS3h-131-2 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTAGGAGACC6TGTCACCATCACTTGCCGG6CAGACA GTTCTATTTTGTGGGCGTTAGCTT66TACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCGA6A6TTCATCCGG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACfACTGTGTTCAGAATGCGGTTTGGCCTGGTACGTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1041)
BMS3h-lBl-B
GACATCCAGATGACCGT6TCTCCATCCTCCCTGTCTGCATCTGTAGGA6ACC6TGTCACCATCACTTGCCGGGCAGATA gttctattttgtgggcgttagcttggtaccagcagaaaccagggaaagcccctaagctcctgatcgagagttcttccgg
CCT6AAC TCAAACC ATT6CAAAGCGGGGTCCCATCACGTTTCAGTGGCAGTG6ATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCT6CAA (U5AmTGCTACGTACTACTOT6TTCAGAATGCGGTTTGGCCTGGTACGTTCGGCCAAGGGACCAAGGTG6AAA \CGG (SEQ ID NO： 1042) BMS3h-131-4 GACATCCA6ATGACCCA6TCTCCATCCTCCCT6TCTGCATCT6TAGGAGACCGTGTCACCATCACTTGCCGGGCAAATA GTTCTATTTTGTGGGCGTTAGCTTGGTACCAGCAGAAACCAG6GAAA6CCCCTAAGCTCCT6ATCGAGAGTTCTTCCGG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATnCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTTTGCTAC6TACTACT6T6TTCAGAAT6C6GTTTG6CCTGGTACGTTCGACCAA6GGACCAAG6TGGAAA TCAAACGG (SEQ ID NO： 1043) BMS3h-131-5 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTA6GAGACC6TGTCACCATCACTTGCCGGGCAAATA GTTCTATTTTGTGGGCGTTA6CTT6GTACCA6CA6AAACCAGG6AAA6CCCCTAAGCTCCTGATCGA6A6TTCTACC6G TTTGCAAAGTGG6GTCCCATCACGTTTCA6T6GCA6T66ATCTGGGACAGATTTCACTCTCACCATCA6CAGTCTGCAA CCT6AA6ATTTT6CTAC6TACTACT6T6TTCAGAATGCG6TTT66CCTGGTACGTTCGGCCAAGGGACCAAGGT6GAAA TCAAACGG (SEQ ID NO： 1044) BMS3h-131-6
GACATCCAGATGACC6T6TCTCCATCCTCCCT6TCTGCATCTGTAGGA6ACC6TGTCACCATCACTTGCCG6GCAAATA GTTCTATTTTGTG6GC6TTA6CTTG6TACCA6CAGAAACCAGGGAAAGCCCCTAAGCTCCTGATC6AGA6TTCTTCCGG ATTGCAAA6CGG66TCCCATCACGTTTCAGTGGCA6TG6ATCTGG6ACAGATTTCACTCTCACCATCA6CA6TCT6CAA CCTGAAGATTTTGCTACGTACTACTGTGTTCAGAATGC66TTTG6CCT6GTACGTTC66CCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO: 1045) 146- 163920.doc 201245225 BMS3h-131-7 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTA6GA6ACC6TGTCACCATCACTTGCCG6GCA6ATA GTTCTATTTTGT6GGCGTTAGCTTGG1ACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCT6ATCGAGAGTTCTTCCGG 下 TTGCAAAGTGG(3GTCCCATCACGTTTCA6TGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCT6AA6ATTTTGCTAC6TACTACTG1GTTCAGAATGCGGTTT6GCCTGGTAC6TTCGACCAAG6GACCAA66T6GAAA TCAAACG6 (SEQ ID NO: 1Θ46) BMS3h-131-8 GACATCCAGATGACCCAGTCTCCATCCTCACT6TCT6CATCTGTA6GA6ACC6TGTCACCATCACTT6CC66GCAAATA GTTCTAT 了 TTGTGGGCGTTAGCTTGGTACCAGi^GAAACCAGGGAAAGCCCCTGAGarCCTGATCGAGAGTTCTTCCGG TCTGCAAAGT6GGGTCCCATCACGTTTCAGT6GCAGTGGATCTGG6ACAGATTTCACTCTCACCATCAGCA6TCTGCAA CCTGAAGATTTTGCTAC6TACTACTGTGTTCA6AAT6C6GTTTGGCCTGGTACGTTCG6CCAAGG6ACCAAGGT66AAA TCAAACGG (SEQ ID NO： 1047) BMS3h-131-9 GACATCCA6AT6ACCCAGTCTCCATCCTCCCT6TCTGCATCTGTAGGA6ACCGTGTCACCATCACTT6CCG6GCGAATA GTTCTATATTGT6GGCGTTGGCTT6GTACCA6CA6AAACCAGG6AAAGCCCCTAAGCTCCT6ATCGA6AGTTCTTCC6G TTTGCAAAGTGGGGTCCCATCACGTTTCA6TGGCAGTGGATCT6GGACAGATTTCACTCTCACCATCAGCAGTCTGCM CCTGAAGATnTGCTACGTACTACTGTGTTCAGAATGCGGTTTGGCaGGTACOTTCGGCCAAGGGACCAAGGTGGAAA ACAAACGG (SEQ ID NO： 1048) BMS3K-131-10
GACATCCA6ATGACCCAGTCTCCATCCTCCCTG 了 CTGCATCTGTAGGAGACCGTGTCACCATCACrTGCCGGGCAAATA GTTCTATTCTCTGGGCGnAGCTTGGTACCAiSCAGAAACCTGGGAAAGCCCCTAAGCTCCTGATCGAGAGTTCTTCCGG TTTGCAAA6TGGGGTCCCATCACGTTTCAGTGGCA6TGGATCT6G6ACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCCGAAGATTITGCTACGTACTACTGTGTTCAGAATGCGGTTTGGCCTGCTACOTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1049) BMS3h-131-ll GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCTTCTGTAGGAGACCGT6TCACCATCACTTGCCGGGCAAATA GTTCTATTTTGTGGGCGTTAGCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCGAGAGTTCTTCCGG TTTGCAAAGTGGGATCCCATCACGTTTCA6TGGCAGTG6ATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCT6CAA CCTGAAGATTTTGCTAC6TACTACTGTGTTCAGAATGCGGTTTG6CCT66TACGTTCGGCCAAGGGACCAA66TGGAAA TCAAACGG (SEQ ID NO: 1Θ5Θ) BMS3h-lBl-12 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCT6TTG6A6ACC6TGTCACCATCACTTGCC6GGCAAATA GTTCTATTTT6TGG(3CGTTAGC：TTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCGAGAGTTCTTCCG6 ATTGCAAAGCGGGGTCCCATCACGmCAGT66CAGTGGATCT666ACAGATnCACTCTCACCATCAGCAGTCTGCAA CC 丁 GAAGATTHGCTACGTACTACTGTGTTCAGAATGCGGTTTGGCCTGGTACGTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1051) BMS3h-131-13 GACATCCTGTTGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTA6GAGACC6T6TCACCATCACTTGCCGGGCAAATA GTTCTATTTTGTGGGC6TTAGCTTGGTACCAGCAGAAACCAGG6AMGCCCCTAAGCTCCT6ATC6A6AGTTCTTCC6G TTTGCAAAGTGGGGTCCCATCAC6TTTCAGTGGCA6TG6ATCT66GACA6ATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTGTTCAGAATGCGGTTTGGCCTGGTACGTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO: 1052) 147- 163920.doc 201245225 BMS3h-131-14 GACATCCAGATGACCCAGTCTCCATCaCCCTGTCTCCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAATA GTTCTATrnrGTGGGCGTTAGCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCGAGAGTTCTTCCGG TTTGCAAAGTGGG6TCCCATCACGTTTCA6T6GAAGT6GAACTGGGACAGATTTCACTCTCACCATCA6C6GTCTGCM CCT6AAGATTTTGCTAC6TACTACTGTGTTCA6AATGC6GmGGCCT6GTAC6TTCGACCAAG6GACCAAGGT6GAAA TCAAACGG (SEQ ID NO: 1053) BMSBh-131-15 6ACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACC6TGTCACCATCCCTTGCC6GGCAAATA 6TTCTATTTTGTG66CGTTAGCTT6GTACCAGCA6AAACCAGGGAAAGCCCCTAA6CTCCTGATCGAGAGTTCTTCCGG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGCATCTG6GACAGATTTCACTCTCACCATCAGCAGTCT6CAA CCTGAAGATTTTGC 丁 ACGTACTACTGTGTTCAGAATGCGGTTTGGCXTGGTACGTTCGGCCAAGGGACCAAGGTGGAGA TCAAACGG (SEQ ID NO: 1054) BMS3h-193-l GACATCCAGATGGCCCA6TCTCCATCCTCCCTGTCTGCATCTGTA6GAGACC6TGTCACCATCACTTGCC6GGCAAGTC AGACGATTGAGC6TCGTTTAAATTGGTATCAGCAGAAACCAGGGAAA6CCCCTAAGCTCCT6ATCTATCTTGCTTCCCG TTT6CAAAGTGGGGTCCCATCACGTTTCAGT66CAGTGGATCTGGGACA6ATTTCACTCTCACCATCAGCAGTCT6CAA CCTGAAGATTTTGCTACGTACTACTGTCATCA6TATGCGAGTCCACCTTTGACGTTAG6CCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO: 1055) BMS3h-193-2 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGTGTCACCATCACTTGCCGGGCAAGTC AGAC6ATTGAGCGTCGTTTAAATTGGTATCAGCAGAAACCAGGGGAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACT6CCATCAGTATGC6AGTCCACCTTTGACGTTC6GCCAAGGGACCAATGTG6AAA TCAAACGG (SEQ ID NO: 1056) BMS3h-19B-3 GACATCCAGAT6ACCCAGTCTCCATCCTCCCTATCTGCATCT6TAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC AGACC3ATTGAGCGTCGTTTAAATTGGTATCAGCAGAAACCAG66AAA6CCCCTAAGCTCCTGATCTATCTT6CTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCA6TCTGCAA CCTGAAGATTTTGCTGCGTACTACTGTCATCAGTACGAGAGTCCACCTTTGACGTTTGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1057) BMS3h-193-4 GACATCCAGA 丁 GACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC GGACGATTGAGCGTCGTTTAAATT66TATCAGCAGAAACCA6GGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCGCG mGCAAAGTGGGGTCCCATCACGTTTCAGTGGCA6TG6ATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCT6CAA CCT6AAGATTTTGCTACGTACTACT6TCATCA6TATGAGAGTCCACCTTTGAC6TTCCGCCAAGGGACCAAA6TGGAAA TCAAACGG (SEQ ID NO: 1Θ58) BMS3h-193-5 6ACATCCAGATGACCCAGTCTCCATCCTCCCT6TCTGCATCTGTAGGAGAACGTGTCACCATCACTTGCC6G6CAA6TC AGACGATTGAGCGTCGTTTAAATTGGTATCAGCAGAAACCAG6GAAA6CCCCTAA6CTCCTGATCTATCTTGCTTCCCG TTT6CAAAGTGGG6TCCCATCACGTTTCAGTG6CAGT6GATCT6GGACAGATTTCACTCTCACCATCAGCAATCTGCAA CCT6AAGAnCTGCTACGTACTACTGTCATCAGTAT6CGAGTCCACCTTTGACGTTAGGCCAAGGGACCAAAGT6GAAA TCAAACGG (SEQ ID NO: 1059) 148·
163920.doc 201245225 BMS3h-193-6 6ACATCCAGATGACCCAGTCTCCATC(TCCCTGTCTGCATCT6TA6GA6ACC6TGTCACCATCACTTGCCGGGCAAGCC AGACGATTGAGCGTCGTTTAAATTGGVATCAGCAGAAACCAGGGAAGGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTVCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTT6CTAC6TACTACTG1CATCAGTAT6CGA6TCCACCTTTGACGTTAGGCCAAGGGACCAAA6T6GAAA TCAAACGG (SEQ ID NO： 1060) BMS3h-193-7 6ACATCCAGATAACCCAGTCTCCATCCTCCCT6TCTGCATCT6TAGGAGACCGTGTCACCATCACTTGCC6GGCAAGTC AGAC6ATTGAGC6TC6TTTAAATTGGrATCA6CA6AAACCA66GAAA6ACCCTAAGCTCCT6ATCTATCTTGCTTCCCG mGCAAAGTGGGGTCCCATCACGTTICAGTGGCAGTGGATC 丁 GGGACA6ATTTCACTCTCACCATCAGCAGTCTGCAA CCT6AAGATTTT6CTACGTACTACT6rCATCAGTATGAGA6TCCTCCTTTGAC6TTC6GCCAAGGGACCAAAGT66AAA TCAAACGG (SEQ ID NO: 1061) BMS3h-19B-8 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACC6TGTCACCATCACTTGCCGG6CAAGTC AGACGATTGAGCGTCGTTTAAATTGGTATCAGCAGAAACCAGGGGAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTT6CAAAGTGGGGTCCCATCACGTTTCAGTGGCAGT6GATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTCATCAGTATGAGAGTCCACCTTTGAC6TTCGGCCAAGGGACCAAAGT6GAAA TCAAATGG (SEQ ID NO: 1062) BMS3h-193-9
GACATCCAGTT6ACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGAGTCACCATCACTTGCCGGGCAA6TC AGACGATTGAGCGTCGTTTAAATT6G1ATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTG6CAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTG1CATCAGTATGAGA6TCCACCTTTGACGTTCGGCCAAGG6ACCAAA6T6GAAA TCAAACGG (SEQ ID NO： 1063) BMS3h-193-10 6ACATCCA6ATGTCCCAGTCTCCATCC：ACCCTGTCT6CATCT6TAGGAGACCGT6TCACCATCACTTGCCG6GCAAGTC AGACGATTGAGCGTCGTTTAAATTGG1ATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTT6CTTCCCG CTTGCAAAGTGGG6TCCCATCAC6TT1CAGTGGCAGTGGATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCT6CAA CCTGAAGATTTTGCTACGTACTACTG1CATCAGTAT6AGA6TCCACCTTT6ATGTTC66CCAAGGGACCAAA6TG6AAA TCAAACGG (SEQ ID NO： 1064) BMS3h-193-ll GACATCCA6AT6ACCCAGTCTCCATCCTCCCTGTCTGCATCT6TAGGAGACCGTGTCACCATTACTTGCCG6GCAAGTC AGACGATTGAGC6TC6TTTAAATTGG1ATCA6CA6AAACCAG66AAA6ACCCTAAGCTCCT6ATCTATCTT6CTTCCCG mGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTOCAA CCAGAAGATTTT6CTACGTACTACT61CATCAGTAT6AGAGTCCACCTTTGACGTTC66CCAAGGGACCAAA6TGGAAA TCAAACGG (SEQ ID NO: 1065) BMS3h-19B-12
GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCT6CATCCOTACGA6ACC6TGTCACCATCACTT6CCGGGCAAGTC A6ACGATTGAGC6TCGTTTAAACTGCTATCAGCAGAAACCAGG6AAA6CCCCTAAGCTCCTGATCTATCTT6CTTCCCG TTTGCAAAGTGGGGTCCCATCACGTnCA6TGGCA6TGGATCTG6GACA6ATTTCACTCTCACCATCA6CAGTCT6CAA CCTGAAGATnTGCTACGTACTACTGTCATCAGTATGAGAGTCCACCTHGACGT 了 CGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO: 1066) 149- 163920.doc 201245225 BMS3h-193-13 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTTTGCATCTGTAGGGGACCCTGTCACCATCAC 了丁 GCCGGGCAAGTC A6ACGATTGAGCGTC6TTTAAATTGGTATCAGCAGAAACCA66GAAA6CCCCTAA6CTCCT6ATCTATCTT6CTTCCC6 nTGCAAAGTGGGCTCCCATCACGmCAOTGGCAGTGGATCTGGGACAGATTTCACTaCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTCATCA6TAT(3AGAGTCCACCTTT6ACGTTC6GCCAAGGGACCAAAGT66AAA TCAAAC6G (SEQ ID NO: 1067) BMS3h-193-14 GACATCCAGAT6ACCCAGTATCCATCCTCCCTGTCTGCATCTGTAGGAGACC6TGTCACCATCACTTGCCG6GCAAGTC AGTC6ATTGA6CGTC6TTTAAATTGGTATCAGCA6AAACCAG6GGAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAA6T6G66TCCCATCACGTTTCAGT6GCAGTG6ATCTGG6ACAGATTTCACTCTCACCATCAGCA6TCTGCAA CCT6AAGATTTT6CTACGTACTACTGTCATCA6TATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACTAAAGT6GAAA TCAAACGG (SEQ ID NO: 1068) BMSBh-193-15 GACATCCAGATGACCCAGTCTCCATCCTCCCT6TCT6CATCTGTA6GAGACCGT6TCACCATCACTTGCCG6GCAA6TC G6ACGATTGA6CGTCGTTTAAATT66TATCA6CAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTC6CG TTT6CAAA6TGG66TCCCATCACGTTTCA6TG6CA6TG6ATCTGG6ACAGATTTCACTCTCACCATCAGCA6TCTGCAA iVGATTTTGCTACGTACTACTGTCATCCGTATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACCAAAGTGGAAA ：G6 (SEQ ID NO： 1069)
CCTGAAC TCAAACC BMS3h-193-16 GACATCCAGAT6ACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAG6AGACCGT6TCACCATCACTTGCC66GCAAGTC AGGC6ATT6AGC6TC6TTTAAATTGGTATCAGCAGAAACCAG6GAAAGCCCCTAA6CTCCTGATCTATCTT6CTTCCCG TTT6CAAA6TGGGGTCCCATCTCGTTTCAGTGGCAGTG6ATCT6GGACAGATTTCACTCTCACCATCAGCAGTCTGCAG CCA6AAGATTTTGCTACGTACTACTGTCATCAGTATGCGAGTCCACCTTT6ACGCTCGGCCAAG6GACCAAAGT6GAAA TCAAACGG (SEQ ID NO: Χ07Θ)
BMS3h-193-17 AACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTAGGAGACCGTGTCACCATCACTTGCC6G6CAAGTC AGGCGATrGA6C6TCGTTTAA/VrTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCTCG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACA6ATTTCACTCTCACCATCA6CAGTCT6CAA CCT6AA6ATTTTGCTACGTACTACTGTCATCAGTAT6A6A6TCCACCTTT6ACGTTCGGCCAAGG6ACCAAAGTG6AAA TCAAACGG (SEQ ID NO： 1071) BMS3h-193-18 GACATCCAGATGACCCA6TaCCATCCTCCCTGTCTGCATCT6TAG6A6ACC6TGTCACCATCACTTGCCGGGCAAGTC AGACGATTGGGCGTCGTrrAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGT66GGTCCCATCACGTTTCAGTGGCAGT6GATCT6G6TCAGATTTCACTCTCACCATCA6CA6TCT6CAA CCTGAAGATTTTGCTACGTACTAC：TGTCATCAGTATGAGAGTCCACCTTTGACGTTCGGCCAAGG6ACCAAAGTGGAAA TCAAACGG (SEQ ID NO: 1072) BMS3h-193-19 GACATCCAGATGACCCA6TCTCCATCCTCCCTTTCTGCATCT6TAGGAGACCGTGTCACCATCACTTGCCGAGCAAGTC AGACGATTGAGCGTCGTTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATaTGCTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTTCA6TGGCAGTGGATCTG6GACAGAATTTACTCTCACCATCAGCA6TCT6CAA CCTGAAGA1
3AAACCAG6GAAAG iXGTGGATCTGGGAC 3ATTTTGCTACGTACTACTGTCATCAGTATGAGA6TCCACCTTTGACGTTCGGCCAAGGGACCAAAGT6GAAA
TCAAACGG (SEQ ID NO： 1073) 163920.doc 150· 201245225 BMS3h-193-20 GACATCCAGATGACCCAGACTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC AGACGATT6AGCGTCGTTTAAATTGGTATCAGCAGAAACCAGGGGAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTrCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCCACGTACTACTGTCATCAGTATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACCAAAGTGAAAA TCAAACGG (SEQ ID NO： 1074) BMS3h-193-21 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGTGTCACCATCACTTGCCGGGCAAGTC AGAC6ATT6AGCGTCGTTTAAATTGGTATCA6CAGAAACCAG6GAAAGCCCCTAAGCTCCTGATCTATCTT6CTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTrCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCCGAAGATTTTGCTACGTACTACTGTCATCAGTATGA6AGTCCACCTTT6ACGTTCGGCCAAGGGACCAAAGTG6AAA TCAAACGG (SEQ ID NO： 1075) BMS3h-193-22 CACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACC6TGTCACCATCACTTGCCGGGCAAGTC AGACGATTGAGCGTCGTnAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTrCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCT6AA6ATTTTGCTACGTACTACTGCCATCAGTAT6AGA6TCCACCTTT6ACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO: 1076) BMS3h-193-23
GACGTCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC AGACGATTGA6C6TCGTTTAAATTGGTATCAGCAGAAACCAGGGGAAGCCCCTAAGCTCCTGATCTATCTTACTTCCCG mGCAAAGCGGGGTCCCATCACGTTTCAGTGGTAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTT6CTACGTACTACTG(：CATCAGTAT6CGAGTCCACCnT6AC6TTCGGCCAAGGGACCAA6GTGGAAA TCAAACGG (SEQ ID NO: 1077) BMS3h-193-24 GACATCCAGATGACCCA6TCGCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCC6G6CAAGTC A6ACGATTGAGCGTC6TTTAAATTGGTATCA6CAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTSrCACCAGTATGAGACTCCACCTTTGACGTTCGGCCAAGGGACCAAAGTGGTAA TCAAACGG (SEQ ID NO： 1078) BMS3h-193-25 GACATCCA6ATGACCCAGTCTCCATCCTCCCT6TCTGCATCTGTAGGAGACC6AGTCACCATCACTTGCCGG6CAAGTC AGACGATTGAGCGTCGTTTAAATTGGrATCAGCAGAAACCTGGGAAAGCCCCTAGGCTCCTGATCTATCTTGCTACCCG TTTGCAAAGTG6GGTCCCATCACGCTTCA6TGGCA6TGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTCATCAGTATGAGA6TCCACCTTTGACGTTCGGCCAA666ACCAAAGTGGAAA TCAAACGG (SEQ ID NO: 1079) BMS3h-193-26 GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACC6TGTCACCATCACTTGCCGGGCAA6TC AGCCGATTGAGCGTCGTTTAAATTGGTATCAGCAGAAGCCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTG666TCCCATGAC6TTTCAGTGGCA6T6GATCTG6GACA6ATTTCACTCTCACCATCA6CAGTCTGCAA CCTGAAGATTTTGCTACATACTACT6rCATCAGTATGAGA6TCCACCTTT6ACGTTC6GCCAA666ACCAAA6TGGAAA TCAAACGG (SEQ ID NO: 1080) 151 - 163920.doc 201245225 BMS3h-193-27 6ACATCCA6ATGACCCA6TCTCCATCCTCCCTGTCTGCATCTGTAGGA6ACC6T6TCACCATCACTT6CCGGGCAA6TC AGACGAnGG6CGTCGTTTAAATTG6TATCAGCAGAAACCAGGGAAA6CCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTTGCAAAGTGGG6TCCCATCACGTTTCAGTGGCAGTGGATCTGGGACA6ATTTCACTCTCACCATCAGCAGTCT6CAA CCTGAAGATTTTGCTACGTACTACTGTCATCAGTAT6AGAGTCCACCTTT6AC6TTC6GCCAAG6GACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1681) BMS3h-193-28 GACATCCAGAT6ACCCAGTCTCCATCCTCCCTGTCTGCATCT6TAG6A6ACCGTGTCACCATCACTTGCCGGGCAA6TC AGTCGATTGAGCGCCGTTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATCTTGCTTCCCG TTT6CAAA6TGGGGTCCCATCACGTTTCAGTGGCA6TGGATCTGGGACA6ATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTTT6CTACGTACTACT6TCATCA6TAT6A6A6TCCTCCTTTGACGTTCG6CCAA6GGACCAAAGTGGAAA TCATAC6G (SEQ ID NO： 1Θ82) BMS3h-X93-29 GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGA6ACCGA6TCACCATCACTTGCCGG6CAA6TC AGACGATTGA6CGTCGTTTAAATT6GTATCAGCAGAAACCT66GAAAGCCCCTAA6CTCCT6ATCTATCTT6CTACCC6 mGCAMCT咖 GTCCCATCACGC^CACT狐 AGTGGATCTGGGACAGATTTCACTCTCACCATCAGCACTCTGC^ CCTGAAGATTTTGCTACGTACTACTGTCATCAGTATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1083) BMS3h-193-B0 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCT6TAGGAGACC6TGTCACCATCACTTGCCGGGCAAGTC AGTCGATTGAGCGCCGTTTAAATT6GTATCAGCAGAAACCA666AAAGCCCCTAAGCTCCT6ATCTATCTTGCTTCCC6 tTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGAmrCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTCATCA6TATGAGAGTCCTCCTTT6ACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1084) BMS3h-193-2501 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTAG6A6ACCGAGTCACCATCACTTGCCGGGCAA6TC AGACGATTGAGCGTCGnTAAATTGGTATCAGCAGAAACCTGGGAAAGGCCCTAGGCTCCTGATCTATCTTGCTACCCG TTTGCAAAGTGGGGTCCCATCACGCTTCAGTGGCAGTGGATCTG66ACAGATTTCACTCTCACCATCA6CA6TCTGCAA CCTGAAGATTTTGCTACGTACTACTGTCATCAGTTC6AGCACCCACCTTTGACGTTC66CCAAGG6ACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1085) BMS3h-193-2502 GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTA6GA6ACCGA6TCACCATCACTT6CCGGGCAAGTT TCCCCATTGACCGTCGTTTAAATTGCTATCAGCAGAAACCTGGGAAAGCCCCTAGGCTCCTGATCTATCTTGCTACCCG TTTGCAAAG 丁 GGGGTCCCATCACGCTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTCTCATCAGTATGAGAGTCCACCmGACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1086) BMS5H-193-2503 GACATCCA6ATGACCCA6TCTCCATCCTCCCTGTCT6CATCTGTAGGA6ACC6A6TCACCATCACTTGCCGG6CAA6TT CCACCATTGGCCGTCGTTTAAATT6GTATCAGCA6AAACCTGG6AAAGCCCCTAGGCTCCTGATCTATCTTGCTACCC6 TTTGCAAAGT6G66TCCCATCACGCTTCA6TGGCAGT66ATCTGGGACA6ATTTCACTCTCACCATCA6CA6TCTGCAA CCT6AAGATTTT6CTAC6TACTACTGTCATCAGTAT6AGAGTCCACCTTTGACGTTCGGCCAAGG6ACCAAAGTGGAAA TCAAACGG (SEQ ID NO: 1 的7) 152-
163920.doc 201245225 BMS3h-193-2504 6ACATCCAGATGACCCAGTCTCCATCi：TCCCT6TCT6CATCTGTAG6AGACCGAGTTACCATCACTTGCC666CAA6TT CCCAGATTGGGCGTCGTTTAAATTGffrACCAGCAGAAACCAGGGAAAGCCCCTAGGCTCCTGATCTATCTTGCTACCCG TTTGCAAA6TGG6GTCCCATCAC6CTrCA6TGGCAGTGGATCT6G6ACA6ATTTCACTCTCACCATCA6CA6TCT6CM CCTGAAGATTrTGCTACOTACTACTGTCATCAGTATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1088)
BMS3h-193-2505 GACATCCA6AT6ACCCAGTCTCCATO：TCCCTGTCTGCATCT6TAGGAGACC6A6TCACCATCACTTGCCG6GCAAGTG AGCG6ATTGGGCGTC6TTTAAATTGGTATCAGCAGAAACCAGGGAAA6CCCCTA66CTCCT6ATCTATCTTGCTACCCG r6CAAA6TG666TCCCATCAC6CTrCAGTGGCAGTGGATCTGGGACA6ATTTCACTCTCACCATCA6«
CAGTCTGCAA AAAGTGGAAA CCT6AA6ATTn6CTACGTACTACTGrCATCAGTAT6A6AGTCCACCTTTGACGTTCGGCCAAGG6ACCAAAGTG« TCAAACGG (SEQ ID NO： 1089) BMS3h-193-25©6 6ACATCCAGATGACCCA6TCTCCATCi：TCCCTGTCT6CATCT6TAG6A6ACC6A6TCACCATCACTTGCC666CAA6TC AGCAGATTGGCCGCCGTTTAAATTGGTATCAGCAGAAACCTGGGAAAGCCCCTAGGCTCCTGATCTATCTTGCTACCCG TTTGCAAAGTGGGGTCCCATCAC6CTrCAGTGGCAGTG6ATCTGGGACAGATTTCACTCTCACCATCA6CAGTCTGCAA CCTGAA6ATTTTGCTACGTACTACTGTCATCAGTATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACCAAA6TGGAAA TCAAACGG (SEQ ID NO: 1090)
BMS3h-193-25C7 GACATCCAGATGACCCAGTCTCCATO：TCCCTGTCT6CATCTGTAGGA<jACCGA6TCACCATCACTTGCCGGGCAAGTC AGCCGATTGCCCGGCGTTTAAATTGGTACCA6CAGAAACCAGGGAAAGCCCCTA6GCTCCTGATCTATCTTGCTACCCG TTTGCAAAGTGGGGTCCCATCACGCTrCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTCATCAGTATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO： 1091) BMS3H-193-2508
rCTGTAGGAG ：AGGGAAAGC GGAACATTGGCCGTCGTTTAAATTGGTACCA6CAGAAACCAG66AMGCCCCTAGGCTCCT6ATCTATCTTGCTACCC6 TTTGCAAAGT6G6GTCCCATCACGCTTCAGTGGCAGTGGATCT6GGACAGATTTCACTCTCACCATCAGCA6TCT6CM CCTGAAGATTTT6CTACGTACTACTGTCATCA6TATGAGA6TCCACCTTTGACGTTCGGCCAAGGGACCAAAGTG6AAA TCAAGCGG (SEQ ID NO： 1092) BMS3h-193-2509 GACATCCAGATGACCCAGTCTCCATCirrCCCTOTCTGCATCTGTAGGAGACCGAGTCACCATCACTTGCCGGGCAAGTC GGAACATTGACCGTCGmAAATTGGTACCAGCAGAAACCAGGGAAAGCCCCTAGGCTCCTGATCTATCTTGCTACCCG TTT6CAAA6TGGGGTCCCATCACGCTTCAGTGGCAOTG6ATCTGG6ACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCTGAAGATTTTGCTAC6TACTACTGTCATCAGTATGA6A6TCCACCTTTGAC6TTC6GCCAAGGGACCAAA6TGGAAA TCAAACGG (SEQ ID NO: 1093) BMS3h-193-2510 GACATCCA6AT6ACCCAGTCTCCATC<rrCCCT6TCTGCATCT6TA6GAGACCGAGTCACCATCACTTGCCGGGCAAGTC A6A6CATT666C6TC6TTrAAATT6ffrACCAGCAGAAACCT6G6AAA6CCCCTA66CTCCT6ATCTATCTT6CTACCC6
TTTGCAAAi CCTGAAGA' TCAAACGG tGTG6GGTCCCATCACGCTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCA6T< TTTTGCTACGTACTACTGTCATCA6TAT6AGAGTCCACCTTT6ACGTTCGGCCAAG6GACCAAAG (SEQ ID NO: 1094)
CTGCAA iTGGAAA 163920.doc 153· 201245225 BMS3h-193-2511 GACATCCAGATGACCCA6TCTCCATCCTCCCT6TCTGCATCTGTAG6A6ACC6AGTCACCATCAC*nOCCGG(3CAAGTC： AGAACATTGGGACGCGTTTAAATT6GTACCAGCA6AAACCA6G6AAA6CCCCTA6GCTCCTGATCTATCTTGCTACCCG TTTGCAAA6T6G6GTCCCATCACGCTTCAGTGGCAGTG6ATCTGGGACAGATTTCACTCTCACCATCA6CAGTCT6CAA CCTGAAGATTTTGCTAC6TACTACTGTCATCAGTAT6A6AGTCCACCTTTGAC6TTCGGCCAAGG6ACCAAAGT6GAAA TCAAACGG (SEQ ID NO： 1095) BMS3H-193-2512 6ACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTAGGAGACCGAGTCACCATCACTTGCCGGGCAAGTG AGGTCATTGGGCGTCGTTTAAATTGGTACCAGCAGAAACCAGG6AAAGCCCCTAGGCTCCT6ATCTATCTT6CTACCC6 mGCAAAGTGGGGTCCCATCACGCTTCAGTGGCAGTGCsATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTAC6TACTACTGTCATCAGTAT6A6AGTCCACCTTTGAC6TTCGGCCAAGGGACCAAA6TG6AAA TCAAACGG (SEQ ID NO: 1096) BMS3h-193-25X3
CCTGAAG TCAAACG 6ACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCTGTAGGAGACCGA6TCACCATCACTTGCCGGGCAAGTG AGGCGATTGGCC6TCGTTTAAATTG6TATCAGCAGAAACCAGGGAAAGCCCCTA6GCTCCT6ATCTATCTTGCTACCCG TTTGCAAAGTGGGGTCCCATCACGCTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA ^GATTTTGCTACGTACTACTGTCATCAGTATGAGAGTCCACCTTTGACGTTCGGCCAAGGGACCAAAGTGGAAA (VCGG (SEQ ID NO: 1097) BMS3h-193-2514
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCT6TAGGA6ACCGAGTCACCATCACTTGCCGGGCAAGTA CCAGCATTGCGC6TCGTTTAAATT6GTATCAGCAGAAACCTGGGAAAGCCCCTA6GCTCCT6ATCTATCTTGCTACCCG TTTGCAAAGTGGG6TCCCATCACGCTTCAGTGGCA6T6GATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTTTGCTAC6TACTACTGTCATCAGTATGAGAGTCCACCTTT6ACGTTCGGCCAAGGGACCAAAGTGGAAA TCAAACGG (SEQ ID NO: 1098) BMS3h-193-2515 GACATCCAGATGACCCA6TCTCCATCCTCCCTGTCT6CATCT6TAGGA6ACCGAGTCACCATCACTTGCCGGGCAAGTT TGAACATTGGGCGTCGTTTAAATTGGTACCAGCAGAAACCAGGGAAAGCCCCTAGGCTCCTGATCTATaTGCTACCCG TTTGCAAAGTGGGGTCCCATCACGCTrCAGTGGCAGTCGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCT6AAGATTTTGCTACGTACTACTGTCATCAGTATGAGAGTCCACCTTT6ACOTTCGGCCAAGGGACCAAA6TGGAAA TCAAACGG (SEQ ID NO； 1099) BMS3h-193-2516 6ACATCCAGAT6ACCCAGTCTCCATCCTCCCTGTCT6CATCTGTA(36AGACCGAGTCACCATCACTT6CCGG6CAA6TC AGACGATT6AGC6TCGTTTAAATTGGTACCA6CAGAAACCA6G6AAA6CCCCTAGGCTCCTGATCTATaTTCGTCGAA GTT6CAAA6TGG6GTCCCATCAC6CTTCA6T6GCAGTGGATCT6G6ACAGATTTCACTCTCACCATCAGCAGTaGCAA CCT6AAGATTTT6CTACGTACTACT6TCATCA6TAT6AGAGTCCACCTTT6ACGTTCG6CCAAGGGACCAAAGTG6AAA TCAAACGG (SEQ ID NO： 11ΘΘ) BMS3H-198-1
6A6GTGCA6CT6TTGGAGTCT66GGGAG6CTT66TTCAGCCTGGGGGGTCCCT6CGTCTCTCCT6TGCA6CCTCC66AT CCACCATTGCTGGCTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGTGTCTCAGCTAHAGTGG TAGT6GTGGTA6CACATACTACGCAGACTCC6T6AA66GCCGGTTCACCATCTCCCGAGAC6ATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGC6TGCC6A6GATACCGCGGTATATTACTGTGC6AGAGATCCTTATAGTTTT6ACTACT GG6GTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO: 1101) • 154· 163920.doc 201245225 BMS3h-198-2 6AGGTGCAGCCGnGGAGTCT66G66y^GGCTT66TACAGCCTGG6GGGTCCCT6C6TCTCTCCTGTGCA6CCTCCGGAT TCACCTTTGCTG6GTATGAGAT6T66'：GGGTCCGCCAG6CTCCAGGGAAG6GTCTAGAGC6GATCTCAGCTATTAGCG6 TAGTGGTGGTAGCACATACTACGCAGACTCCGT6AAGGGCC6GTTCACCATCTCCCGC6AC6ATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGCGT6C(：6AGGATACCGCGGTATATTACTGTGC6AGAGATCCTTATAGTTTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCVCGAGC (SEQ ID NO： 1102) BMS3h-198-3 GA6GTGCAGCTGTTG6A6TCTGGGGG/\G6CTCGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCTGT6CA6CCACCGGAT CCACCTTTGCTGGGTATGA6ATGT6GT666TCCGCCA66CTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAGTG6 TAGT6GTGGTAGCACATACTACGCAG/1CTCCGT6AAGG6CCGGTTCACCATCTCCCGCGACGATTCCAA6AACACGCTG TATCTGCAAATGAACAGCCTGCOTGCCGAGGATACCGCGGTATATTACTGTGCGAGAGATCCTTACAGTTATGACTACT GGGGTCAGGGAACCCTGOTCTCCGTCTCGAGC (SEQ ID NO： 1103) BMS3h-198-4 GAGGT6CAGCTGTTGGA6TCT66666/iG6CTTG6TACAGCCTGGG66GTCCCTGCGTCTCTCCTGTGCA6CCTCCG6AC TCACCTTTGCTGGGTATGAGAT6T66TGG6TCCGCCAGGCACCAGGGAA666TCTAGA6C6G6TCTCAGCTATTAGT66 TAGTGGTGGTAGCACATACTACGCAG/iCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAAT6AACA6CCTGCGT6CCGAGGATACCGCA6TATATCACT6TGCGAGAGATCCTTATAGTTTTGACTACT GGGGTCAGGGAACCCTGGTCACC6TC1CGAGC (SEQ ID NO: 1104) BMS3H-198-5
GAGGTGCAGCTOTTGGAGTCTGGGGGAGGCTTCGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTCTGCAGCCTCCGGAT TCACCTTTGCTGGGTATGAGATGTGGIGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAGTGG TA6T6GTG6TAGCACATACTACGCAG/£TCTGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAATGMCAGCCTGC6TGCC6A6GATACCGC6GTATATCACTGTGCGAAA6AACCTTATAGTTATGACTACT 6GGGTCAG6GAACCCTG6TCACC6TC1CGAGC (SEQ ID NO： 1105) BMS3h-198-6 GAG6TGCAGCT6nGGA6TCT66666/.GGCTTGGTACAGCCT666GGGTCCCTGC6TCTCTCCTGTGCAGCCTCCG6AT CCACCTTT6CTGGGTATGAGATGTGG1G66TCCGCCAGGCTCCAGGGAA66GTCTAGAGCGGGTCTCAGCTATTAGTGG TAGTGGTGGTAGCACATACTACGCA6^.CTCC6T6AA66GCC6GTTCACCATCTCCCGCGACGATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGTCCCGAGGATACCGCGGTATATTACTGTGTGAAAGATCCTTATAGmrTGACTACT GGGGTCAGGGAACCCTGGTCACCGTC1CGAGC (SEQ ID NO： 1106) BMSBh-198-7 GA6GT6CAGCTGnGGAGTCTGG6GG^GGCTTGGTACAGCCTGGGeGGTCCCT6C6TCTCTCCTGTGCAGCCTCCeGAT CCACCATTGCCGGGTATGAGAT6TGGTG6GTCCGCCAG6CTCC6GGGAAG6GTCTAGA6CGGGTCTCAGCTATTAGT6G TAGTGGTGGTAGCACATACTACGCAGAC 丁 CCGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG 了 ATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATAHACTCTGCGAGAGATCCTTATAGTnTGACTACT GGG6TCAG6GAACCCCGGTCACC6TCTCGAGC (SEQ ID NO： 1107) BMS3h-198-8 GAGOTGCAGCTGATGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT CCACCTTTGCTGGGTATGA6ATGTGG7GGTACCGCCAGGCTCCAGGGAAG6GTCTAGAGCGGGTCTCAGCTATTAGT6G AAGTGGTAGAAGCACATACTACGCAG^CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCCTTATAGTTTT6ACTACT G66GTCA6GGAACCCT6GTCACC6TCTCGAGC (SEQ ID NO： 1108) -155· 163920.doc 201245225 BMSBh-198-9 6AG6TGCAGCTGCTGGAGTCTGG666AGGCn66TACAGCCTGGGGG6TCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTT6CTGG6TAT6AGATGT6GTGGGTCCGCCAGGCTCCAGGGAAG6GTCTAGAGCGGGTCTCAGCTATTAGTGG TA6T6GTGGTA6CACGTACTACGCA6ACTCC6T6AAGGGCCGGTTCACCATCTCCCGC6ACGATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCT6C6T6CCGAGGATACCGCAGTATATTACTGTGCGAAAGAACCTTATAGTTTTGACTACT 66GGTCA6GGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1109) BMSBh-198-10 GAG6T6CA6CTGTTGGAGTCT6GGG6AGGCTTG6TACA6CCTGG6GGGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT (iCACCAHGCTGGGTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTAUAG 丁 GG TAGTGGTCGTAGCACATACTACGCAGAaCCOTGAAGGGCCGOTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCCATATAGTTTTGACTACT 6GG6TCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 1110) BMS3h-198-ll 6AGOTGCAGCTGTTGGAGTCTGGG66AGGCTTG6TACA6CCTGGGG66TCCCT6CGTCTCTCCTGTCCAGCCTCCG6AT TCACCTTTGCT6GGTATGAGATGTGGT6GGTCC6CCAGGCTCCAGGGAA666TCTAGA6CGGGTCTCA6CTATTAGT66 TA6TGGT6GTAGCACATACTAC6CAGACTCC6TGAA6G6CC66TTCACCATCTCCCGCGACGATTCCAAGAACAC6CT6 TATCTGCAAATGAACAGCCTGCGTGCCGA66ATACCGC66TATATTACT6T6C6AGA6ACCCTTATAGTTTT6ACTACT 666GTCAGG6AACCCTGGTCTCCGTCTC6AGC (SEQ ID NO： 1111) BMS3h-198-12 6AGGTGCAGCTGTTG6A6TCT6GG6GAGGCTTGGTACAGCCT6GGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCC6GAT TCACCATTGCTGGGTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCCGCTATTAGTGG TA6TG6TGGTAGCACATACTACGCGGACTCCGT6AAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACAC6CTG TATC 下 GCAMTGAA⑽ CCTGCGTGCCGAGGATACCGC 猫ATAmCTGTGCGAAAGATCCTTATAGH 丌 6666TCAGGGAACCCTGGTCACCGTTTC6AGC (SEQ ID NO: 1112) BMS3h-198-13 GAG6TGCAGCTGTTGGA6TCT66G66AGGCTTG6TACA6CCT6G66G6TCCCT6CGTCTCTCCTGTGCAGCCTCC66AT TCACCmGCTGGGTATGAGATCTGCTGGOTCCGCCAGGCTCCAGGGMGGCTCTAGAGCCTGTCTCAGCTATTAGTG^ TAGT66TGGTAGCACATACTACGCAGACTCCGTGAAG66CCG6TTCACCATCACCCGC6ACGATTCCAAGAACAC6CTG TATCTGCAAATGAACA6CCT6CGTGCCGA6GATACCGC66TATATTACT6TGCGAAA6A6CCTTATA6TTTTGACTACT G6GGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 1113) BMS3h-198-14 GAGGT6CAGCTGTT6GAGTCTG6GGGAGGCTTG6TACA6CCTGGG(3GGTCCCTGC6TCTCTCCTGTGCAGCCTCCG6AT TCACCTTTGCTGGGTATGAGATGTGGTG6TTCC6CCAG6CTCCAGGGAAGG6TCTAGAGCGGGTCTCAGCTATTAGTGG TA6TGGTGGTA6CACATACTACGCAGACTCCGTGAAGG6CC6GTTCACCATCTCCCGCGAC6ATACCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCCTTATAGrnTGACTAC 了 GGCGTCAGGGAACCCTGGTCACC6TCTCGAGC (SEQ ID NO： 1114) BMS3h-198-15 GA6GTGCAGCTGTTGGAGTCTGGG66AGGCTTGGTACA6CCTG6G6G6TCCCTGCGTCTCTCCTGT6CAGCCTCCG6AT CCACCTTTGCTGGGTATGAGGTGTGGTG6GTCCGCCAGGCTCCAG66AAGGGTCTG6AGCGG6TCTCA6CTATTAGTGG TAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGC6ACGATTCCAAGAACACGCTG TATCTGCAAAT6AACAGCCT6C6TGCCGAGGATACCGCG6TATATTACTGTGC6AGAGATCCTTATAGTTTTGACTACT G6GGTCAGG6AACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 1115) •156·
163920.doc 201245225 BMSBh-198-16 6AGGTGCAGCTGTTGGAGTCTGGGGGAG6CTTGGTACA6CCTG6G6GGTCCCT6C6TCTCTCCTGTGCAGCCTCC6GAT CCACCTTTGC 丁 GGGTATGAGATGTGGTG66TCCGCCAGGCTCCAGGGAAGG6TCTAGAGCG6ATC 了 CAGCTATTAGTGG TAGTGGTGGTAGCACATACTACGCAGAaCCGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCT6AAAATGAACAGCCTGCGTGCC6AGGATACCGCGGTATATTACT6T6CGAAA6ATCCTTATAGTTTTGACTACT GGGGTCAG6GAACCCT6GTCACCGTCTC6A6C (SEQ ID NO: 1116) BMS3h-198-17 GAGGTGCAGCT6TTGGAGTCTGGGGGi\GGCTTGGTACAGCCTGGGGGGTCCCTGCGTaCTCCT6T6CAGCCTCC6GAT TCACCTTTGCTGG6TATGAGAT6TGGTGGGTCCGCCAGGCTCCAG6GAA6GGTCTA6A6CGGGTCTCAGCTATTAGTGG TAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGG6CC6GTTCACCATCTCCCGCGAC6ATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAGAGATCCTTATAGTTTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ 10 NO: 1117) BMS3h-198-18 . GAGGTGCAGCTGTTGGAGTCTG6GG&\GGCTTGGTACA6CCT6GGGG6TCCCTGCGTCTCTCCTGT6CAGCCTCCGGAC TCACCTTTGCTGGGTATGAGATGT6GT6GGTCCGCCGGGCTCCAGGGAAGG6TCTAGAGCGGGTCGCAGCTATTAGTGG TA6TGGTGGTA6CACATACTACGCAGi\CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGAC6ATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAGAGATCCTTATAGTTTTGACTACT GGG6TCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1118) BMS3h-198-19
6AGGTGCA6CTGTT66AGTCTGGGGGj\GGCTTGGTACA6CCTGGQGGGTCCCT6CGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGCTGGGTATGAGTTG 丁 GGrGGGTCCGCCAGGCCCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAGTGG AAGTGGTGGTAGCACATACTACGCAGi\CTCC6T6AAG(；6CCGGTTCACCATCTCCCGCGACGATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAGAGATCCTTATAGTTTTGACTACC 6GG6TCAGGQAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 1119) BMS3h-198-20 GAGGT6CAGCTGTTGGAGTCTGGGGGi\GGCTTGGTACAGCCTGGGGGGTCCCT6CGTCTCTCCT6TGCAGCCCCCGGAT TCACCTTAGCTGG6TATGAGATGTGGT6G6TCCGCCAGGCTCCA66GAA6GGTCTAGAGCGGGTCTCAGCTATTAGTG6 TAGTGGTGGTAGCACATACTACGCAGACTCC6TGAA6GGCCGGTTCACCATCTCCCGCGAC6ATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGTGCl：GAGGATACC6CGGTATATTACT6TGCGAAAGAACCTTATAGmTGACTACT 6GGGTCAGGGAACCCT6GTCACCGTCTCGAGC (SEQ ID NO: 1120) BMS3h-198-21 6AGGTGCAGCTGTT6GAGTCTGGGGGAGGCTT6GTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAC TCACCTTTGCTGGGTATGAGATGTGGTGGGTCCGTCGGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAGTGG TAGTG6TGGTAGCACATACTACGCAG;\CTCC6TGAAGGGCCGGTTCACCACCTCCCGC6ACGATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGC6T6CCGA6GATACCGC6GTATATTACT6T6CGAGAGATCCTTATAGTTTTGACTACT GG6GTCGGGGAACCCT6GTCACCGTCTC6A6C (SEQ ID NO： 1121) BMS3h-198-22 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCCGGGGGGTCCCTGCGTCTCTCCTGTGCCGCCTCCGGAT TCACCTTTGCTGGGTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAGTGG TAGC66TG6TAGCACATACTACGCA6i\CTCC6T6AAG66CCG6TTCACCATCTCCCGCGAC6ATTCCAAGAACAC6CT6 TATCTGCAAAT6AACAGCCTGC6TGC(：GA6GATACCGCG6TATATTACTGTGCGAAAGAACCTTATAGnATGACTACT GGG6TCATGGAACCCTGGTTACTGTCTCGAGC (SEQ ID NO： 1122) -157· 163920.doc 201245225 BMS3h-198-23 GAG6TGCAGCCGTTG6AGTCTGGGGGAGGCTT6GTACAGCCTGG66G6TCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGCTGGGTATGAGATGT6GTGGGTCC6CCA6GCTCCAGG6AAGGGTCTAGAGCGGGTCTCA6CTATTAGTGG TA6TG6TG6TAACACATACTACGCAGACTCCGTGAA6GGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCT6CAAAT6AACAGCCTGCGTGCC6AG6ATACC6GGGTATATTACTGTGCGA6A6ATCCTTATAGTTTTGACTACT GGGGTCA6GGTACCCTGGTCACCGTCTCGA6C (SEQ ID NO: 1123) BMSBh-198-24 GAGGTGCA6CTGTTGGAGTCTGG66GAGGCTT6GTACAGCCT6GGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCC66AT TCACCTTTGCTGGGTATGAGATGTG6TGGGTCCGCCAGGCTCCAG66AAGG6TCTAGA6C6G6TCTCA6CTATTA6TGG TA6TGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAATGAACA6CCTGCGT6CCGAGGATACCGCGGTATATTACTGTGCGAAAGAACCTTATAGTTTTGACTCCT GGGGTCAGGGAACCCTG6TCACC6TCTCGA6C (SEQ ID NO: 1124) BMSBh-198-25 GA6GCGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGG6GGGTCCCTGCGTCTCTCCTGT6CAGCCTCCGGAT TAACCTTCGCT6G6TAT6AGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGC6CGTCTCA6CTATTAGT6G TAGTGGC6GTAGCACATACTACGCAGACTCCGT6AAGGGCC6GTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATC 丁 GCAAATGAACAGCaGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAGAGATCCTTATAGTTTTGACTACT GGGGTCAGGGAACCCT6GTCACC6TCTCGA6C (SEQ ID NO: 1125) BMSBh-198-26 GAGGT6CAGCTGTTGGA6TCTGG6GGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT CCACCTTTGCTGGGTATGA6AT6T6GTGGGTCCGCCA6GCTCCAG66AA6G6TCTAGAGC6GGTCTCAGCTATTAGTGG TAGTGGTCSCSTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCTCCATCTCCCGCGACGATTCCAAGAACACGC 丁 G TATCTGCAAATGAACAGCCTGCGTGCCGAGCSATACCGCGGTATATTACTGTGCGAAAGAACCTTATAGTTTTGACCACT GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 1126) BMS3H-198-27 GAGG 丁 GCAGCTGTTGGAGTCTOGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCGGGAT CCACCTTTGCTGGGTATGAGATGTGGTGGGTCCGCAG6GCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTA6TGG TAGTGGTGGTAGCACATACTACGCAGACTCCGTGMGGGCCGGTTCACCATCTCCCGCGACeATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAGAGATCCTTATAGTTTTGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTCGA6C (SEQ ID NO： 1127) BMS3h-198-28 6AGGTGCAGCTGTTGGA6TCTGGGGGAGGCTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCTGT6CA6CCTCC6GAT TCACCTTTGCTGGGTATGA6ATGTG6TGGTTCCGCCAGGCTCCAG6GAAG66TCTAGAGC6G6TCTCA6CTATTA6T66 TAGT66TGGTAGCACATACTACGCAGACTCCGT6AA666CCGGTTCACCATCTCCCGCGACGATTCCAA6AACAC6CTG TATCTGCAAATGAACAGCCTGCOTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCCTTATAGTTTTGACAACT GG66TCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 1128) BMS3h-198-29 GAGGTGCAGCTGTT6GAGTCTGGGGGA6GCTTG6TAGA6CCTGGGGGGTCCCT6CGTCTCTCCT6TGCAGCCTCCG6AT TCACCTTTGCTGG6TATGAGAT6TGGTGGGTCCGCCAGGCTCCAGGGAAGG6TCTAGAGCGGOTCTCAGCTATTA6TGG TAGTGGTGGTAGCACATACTACaAGAaCCGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAAtGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGAACCTTATAGTTTTGACCACC 66GGTCA66GAACCCTG6TCACCGTCTCGA6C (SEQ ID NO: 1129) -158-
163920.doc 201245225 BMS3h-198-30 GAGGTGCAGCTGTTGGA6TCTG6GGGA66CTTGGTACAGCCTG6GGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT ACACCTTT6CTG6GTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAGTGG TA6TGGTGGTAGCACATACTACGCAGACTCC6TGAAGGGCC6GTTCACCATCTCCCGCGAC6ATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCCTGCCGAGGATACCGC(3GTATATTACTGTC5CGAAAGAACCTTATAGTTT 丁 6ACCACC GGGGTCAGGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1130) BMS3h-198-31 6AGGTGCAGCTGTTGGAGTCTG66GGA66CTTGGTACAGCCT6GG6GGTCCCTGC6TCTCTCCTGTGCAGCCTCC6GAT TCACCTTTGCTGGGTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAGTGG TAGT6GTGGTAGCACATACTACGCAGACTCTGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGC6T6CCGAGGATACCGCGGTATATCACTGTGCGAAA6AACCTTATAGTTATGACTACT GGGGTCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO： 1131) BMS3h-198-32 GAGGTGCAGCTGTTGGAGTCTGG6GGAGGCTTGGTACAGCCTGGGGG6TCCCT6CGTCTCTCCTGT6CAGCCTCCG6AT TCACCTTTGCTGGGTATGA6AT6TGGTGGTTCCGCCAGGCTCCAGGGAAG6GTCTAGAGCGG6TCTCAGCTATTA6T66 TAGTGGTGGTAGCACATACTAC6CAGACTCCGTGAAGGGCC6GTTCACCATCTCCC6CGACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCG 丁 GCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCCTTATAGTTTTGACAACT GG6GTCA6GGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO: 1132) 8MS3h-198-33
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTG6GGGGTCCCTGC6TCTCTCCTGTGCAGCCTCCGGAT TCACCTTTGCTGGGTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCAGCTAnAGTGG TAGTGGTGGTAGCACATACTACGCAGi^CTCTGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGAACCTTATAGTTATGACTACT GGGGTCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1133) BMS3h-198-34 GAGGTGCAGCT6TTGGAGTCTGGGGGAGGCTTG6TACAGCCT6GGGGGTCCCTGC6TCTCTCCTGT6CAGCCTCC6GAT TCACCTTTGCT6GGTATGA6AT6TGGTG6GTCC6CCAGGCTCCCG66M6GGTCTAGA6CGGGTCTCAGCTATTAGT6G TAGT6GTGGTAGCACATACTACGCAGACTCC6T6AAG66CC6GTTCACCATCTCCCGCGACGATTCCAAGAACAC6CT6 TATCT6CAAATGAACAGCCTGC6T6C(：GAGGATACCGCGGTATAma6TGCGAAAGATCCTTATA6TTTT6ACAACT GGGGTCA6G6AACCCT6GTCACCGTC7CGAGC (SEQ ID NO: 1134) BMS3h-198-35 GAG6TGCAGCTGTTGGAGTCTGGGGGA66CTTG6TACA6CCTGG66G6TCCCT6C6TCTCTCCTGT6CAGCCTCCGGAT TCACCTTTGCTGGGTATGAGATGTGGrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTGG TAGTG6T6GTAGCACATACTACGCAG；VCTCTGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCT6CAAATGAACA6CCTGC6TGC(：6A6GATACC6C6GTATATCACT6T6C6AAA6AACCTTATAGTTATGACTACT 6GGGTCAGGGAACCCTGGTCACC6TCVC6A6C (SEQ ID NO： 1135) BMS3h-198-36 GAGGTGCAGCT6TTGGA6TCTGG6GG/^GGCTTGGTACAGCa6GGGGGTCCCT6CGTCTCTCCTGTGCAGCCTCC66AT TCACCTTTGCTGGGTATGAGATGTGGTGGTTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCAGCTTnTAG 了 GG TAGTGGTGGTAGCACATACTACGCAG/iCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGCGAAAGATCCTTATAGTTTTGACAACT GGG6TCAGG6AACCCTGGTCACCGTCTCGAGC (SEQ ID NO: 1136) 159· 163920.doc 201245225 BMSBh-198-37 6AGGTGCAGCTGTTGGA6TCTG6GGGAGGCTTG6TACAGCCT6GGG6GTCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACCTTTGCTG66TATGAGTT6T6GTG66TCCGCCA66CCCCA6GGAA6GGTCTAGA6CG6GTCTCAGCTATTAGTG6 AA6TGGT6GTA6CACATACTACGCAGACTCCGT6AAGGGCCGGTTCACCATCTCCCGC6ACGATTCCAAGAACAC6CTG TATCT6CAAATGAACAGCCT6C6T6CCGAGGATACCGC66TATATTACTGTGC6AAA6ATCCTTATAGTTTT6ACTACC 6GGGTCA66GAACCCTG6TCACC6TCTC6AGC (SEQ ID NO: 1137) BMS3H-198-38 GAGCTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCC 丁 GT6CAGCCTCCGGAT TCACCTTT6CT66GTATGAGTT6T66T6GGTCCGCCAGGCCCCAGG6AA6GGTCTAGAGCGGGTCTCA6CTATTA6TGG AAGTG6TG6TA6CACATACTACGCAGACTCC6TGAA6G6CC6GTTCACCATCTCCC6CGACGATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCC6AG6ATACCGCGGTATAHACTGTGCGA6A6ATCCTTATA6TTTTGACTACT GGG6TCA6GGMCCCTG6TCACCGTCTCGAGC (SEQ ID NO: 1138) BMS3h-202-l GA6GT6CAGCT6TTGGA6TCTG6GGGGGGCTTGGTACAGCCTGGGG6GTCCCTGCGTCTCTCCTGTGCAGCCTCC<3GAT TCACCTTTCC6ACTGCTGAGAT6CT6fGGGTCCGCAAG6CTCCAGGGAA66GTCTAGA6TGGGTCTCATCTATTTCGGC TA6T6GTG6TTCTACATACTACGCAGACTCCGT6AA6GGCCGGTTCACCATCTCCCGCGACAATTCCAA6AACACGCT6 TATCTGCAAATGAACAGCCTGC6T6CCGAGGACACCGCGGTATATTACTGTGCGAAA6AGCCG6T6AGTTATGTGGC6A C6TTT6ACTACTGG6GTCAGGGAACCCTG6TCACCGTCTCGAGC (SEQ ID NO: 1139) BMS3h-202-2 GA66T6CAGCT6TTG6TGTCTGG6<56AGGCTT66TACA6CCT6G6GG6TCCCT6CGTCTCTCCT6TGCAGCCTCC66AT TCACCTTTCCGACTGCTGAGATGTT6TGG6TCCGCCAGGCTCCAGGGAAG6GTCCAGA6TG66TCTCATCAATTTCGGC 了 AGTG(3TGGTTCTACATACTATGCAGACTCCCT6AA<3GGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACAC6CTG TATCTGCAAATGAACAGCCTGCGTGCC6AG6ACACCGCGGTATATTACTGTGCGAAAGA6CCGGT6AGTTATGTG6CGA CGTTTGACTACTGG6GTCA6GGMCCCTGGTCACC6TCTCGAGC (SEQ ID NO： 1140) BMS3h-202-3 GAGGTGCA6CTGTTGGA6TCTG6GGGA6GCTTGGTACAGCCT666GG6TCCCTGCGTCTCTCGTGTGCAGCCTCCGGAT TCACCTTTCC6ACTGCCGA6ATGGTGTGGGTCCGCM6GCTCCAGGGATGGGTCTAGAGTGGGTCTCATCTATTTC66C TAGTG6TGGTTATACATACTACGCA6ACTCCGTGAAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACATGCT6 TATCTGCAAATGAACAGCCTGC6TGCCGAGGACACCGC6GTATATTACT6TGC6AAAGAGCCGGTGAGTTATGTGGC6A CGTTTGACTACTGGGGTCAGGGAGCCCTGGTCACCGTCACGAeC (SEQ ID NO： 1141) BNS3h-202-4 6A6GT6CAGCTGTTGGTGTCT6GGGGAGGCTTGGTACAGCCTGGGGG6TCCCTGCGTCTCTCCT6T6CA6CCTCCG6AT TCACCTTTCCGACTGCTGAGATGGTGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTTCGGC TAGTGGTGGTTCTACATACTACGCA6ACTCCGTGAAGGGCCGGTTCTCCATCTCCCGCGACGATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTAC 下 CTGCGAAAGAGCCGGTGACTTATGTGGCGA CGTTT6ACTACTGG6GTCATG6A6CCCTGGTCACC6TCTCGAGC (SEQ ID NO: 1142) BMS3h-202-5 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT TCACAnTCCGACTGCTGAGATGTTGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTTCGGC TAGTGGTGGTTCTACATACTACGCAGACTCCGTGAAGGGCCG6TTCACCATCTCCC6CGACAATTCCAAGAACACGCT6 TATCTGCAAATGAACAGCCTGCGA6CCGAGGACACC6CGGTATATTACTGTGCGAAAGAGCCGGTGAGTTAT6TGGCAA CGTTTGACTACTGGGGTCAjSGGAACCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1143) 160 _
163920.doc 201245225 BMS3h-202-6 GAGGCGCAGCTGTTGGAGTCT6G6G6TG6CTTGGTACAGCCTG6GGGGTCCCT6C6TCTCTCCTGT6CAGCCTCCG6AT TCACCTTTCC6ACTGCTGAGATG6T6TG6GTCCGCCAGGCTCCAGGGAAGGGTCTA6AGTGGATCTCATCTATTTCGGC TAGTGGT6GTTCTACATACTACGCAGACTCCOTGAAGGGCCGGTTCACCATCTCCC6C6ACAATTCCAAGAACACGCT6 TATCTGCAATTGAACAGCCTGCGTGCCGAG6ACACCGCGGTATATTACTGTGC6AAAGAGCCGGTGAGTTAT6T6GCGA CGTTTGACTACTG66GTCGGG6AACCCTGGTCACC6TCTC6AGC (SEQ ID NO: 1144) BMS3h-202-7 GAGGT6CAGCTGTTGGAGTCTG6GGG^G6CTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCG6AT TCACATTTCCGACTGCTGAGATGnGrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTATTTCGGC TAGTGGTGGTTCTACATACTACGCAG 久 CTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAGCACGCTG TATCTGCAAATGAACAGCCTGCGTGCC6AG6ACACC6CG6TATATTACTGT6CGAAAGAGCC6GTGAGTTATGTGGC6A CGTTT6ACTACTGGGGTCCAG6AGCCCT6GTCACCGTCTCGAGC <SEQ ID NO: 1145) BMS3h-202-8 GAGGTGCAGCTGTTGGAGTCCGGGGG,^GGCTTGGTACAGCCTGGGGGGTCCCTGC6TCTCTCCTGTGCAGCCTCC66AT TCACCTTTCCGACTGCTGAGATGCTffrGGGTCCGCAAGGCTCCAGGGAAGGGT.CTAGAGTGGGTCTCATCTATTTCGGC TAGT6GTGGTTCTACATACTAC6CAG!VCTCCGT6AAGGGCCGGTTCACCATCTCCCGC6ACAATTCCAAGAACACGCTG TTTCTGCAflATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCCAAAGAGCCGGTGAGTTATGTGGCGA CGTTTGACTACTGGG6TCAGG6AACCCT6GTCACCGTCTCGAGC (SEQ ID NO： 1146) BMS3h-202-9
GAGGTGCAGCTGTTG6AGTCTGGGGG\GGCTT6GTACAGCCTGGGG<jGTCCCTGCGTCTCTCCT6TGCAGCCTCCGGAT 了 CACATTTCCGACTGCTGAGATGTTGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTC 下 CATCTATTTCGGC TAGTGGTGGTTCTACATACTACGCAGAaCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCT6CAAATGAACAGCCTGC6T60：GAG6ACACC6CGGTATATTACTGT6C6AAAGAGCCGGTGAGTTATGTGGC6A CGTTTGACTACTGGGGTCCAGGAGCCCTGGTCACCGTCTCGAGC (SEQ ID NO： 1147) BM53h-202-10 GAGGTGCAGCTGTTGGAGTCT66GGGi\G6CTTG6TACAGCCT6GGGGGTCCCT6CGTCTCTCCT6TGCAGCCTCCG6AT TCACCTTTCCGACTGCTGAGATGCTGrGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTrCATCTATTTCGGC TAGTGGTGGTTCTACATACTACGCAGiVCTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATTTGCAAATGAACAGCCTGC6TGC<：GA6GACACCGC66TATATTACTGTGCGAAA6AGCC6GTGTATTAT6TGGC6A CGTTTGACTACTGGG6TCAGGGAACCCTGGTCACCGTCTC6AGC (SEQ ID NO: U48). BMS3h-202-ll GAGGTGCAGCTGTT6GA6TCCGGGG6>V66CTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGAT 丁 CACCTTTCCGACTGCTGAGATGCTGTGGCTCCGCAAGGCTCCAGGGAAGGGTCTAGAGTGGGTCTCATCTAmCGGC TAOTGGTGOTTCTACATACTACGCAG 八CTCCGTGMGGGCCGGHCACCATCTCCCGCGACAATTCCAAGAACACGCTG TATCTGCAAATGAACAGCCTGCGTGCCGAG6AC6CC6CGGTATATTACT6TGCGAAAGAGCCGGTGAGTTATGTGGCGA CGTTT6ACTACTGGGGTCAGG6AACC(：T6GTCACCGTCTC6A6C (SEQ ID NO: 1149) BMS3h-217-l MCATCCAGATGACCCAGTCTCCATC<:TCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCC(5GGCAAGTC ATTTTAT 丁 GGTACTCTGHAACTTGGTACCAGCATAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCnT GTTGCAAA6TG6GGTCCCATCACGTTTCAGTGGCA6T66ATCT666ACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTAC6TACTACTGTGGTCAGGG6GTGCTGTGGCCTGCGACGTTCGGCCAA6G6ACCAAGGTGGAAA TCAAAC6G (SEQ ID NO： 1150) -161 - 163920.doc 201245225 BMS3h-217-2 GACATCCAGATGACCCA6TCTCCATCCTCCCTGTCT6CATCT6TAGGAGACC6TGTCACCATCACTTGCCGG6CAAGTC ATTTTATTGGTACTCT6TTATCTTGGTACCA6CA6AAACCACGGAAAGCCCCTAAACTCCTGATCACTTATG6TTCCTT GTTGCAAAGTGGGCTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAG 丁 CTGCAT CaGAAGATTTTGCTAC6TACTACTGTGGTCAGGGG6TGCTGTGGCCTCCGACGTTCGGTCAAGGGACCAAG6TGGAAA TCAAACG6 (SEQ ID NO： 1151) BMS3h-217-3 GACATCCAGAT6ACCCAGTCTCCGTCCTCCCTGACTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAA6TC AHmTTGGTACTCTOTTATCHGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCC 了 GGTCACTTATGGTTCCTT GTT6CAAACT6666TCCCATCAC6TTTCA6TGGCAGTGGATCT6GGACA6ATTTCACTCTCACCATCAGCAATCTGCAA CCTGAA6ATTTTGCTACGTACTACTGTGGTCA666G6TGCTGTGGCCTCCTACGTTCGGCCAAGG6ACCAAG6TGGAAA ACATACG6 (SEQ ID NO： 1152) BMSBh-217-4 GACATCCA6ATGACCCA6TCTCCATCCTCCCTGTCT6CATCT6TAGGA6ACCGT6TCACCATCACTTGCC66GCAAGTC ATTTTATTGCTACTCTGTTATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGT66GGTCCCATCACGTTTCA6TGGCA6TG6ATCTGG6ACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCTGAA6ATTTTGCTAC6TACTACT6TG6TCAGG6GGTGCT(；TGGCCTCC6ACGTTCG6CCMGG6ACCAAGGT6GAAA TCAAACG6 (SEQ ID NO： 1153) BMS3H-217-5
GACATCCA6AT6ACCCA6TCTCCATCCTTCCTGTCTGCATCTGTA6GAGACCGT6TCACCATCACTTGCCGG6CAAGTC ATTTTATTGCTACTCTGTTATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGTGGGGTCCCATCAC6TTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCTGAAGATTTTGCTACGTACTACT6TGGTCAGGGGGTGCTGTGGCCTCCGACGTTCGGCCAAGG6ACCAA66TGGAAA TCAAACGG (SEQ ID NO： 1154) BMS3h-217-6
CCTGAAG TCAAACC GACATCCAGATGACCCA6TaCCATCCTCCCTGTCTGCATCTGTAGGAGACC6TGTCACCATCACTT6CCGGGCAA6TC ATTTTATT6GTACTCTGTTATCTT6GTACCAGCAGAAACCAGG6AAAGCCACTAAGCTCCT6ATCACTTATG6TTCCTT GTTGCAAAGT6GGGTCCCATCAC6TTTCAGTGGCA6TGGATCT6GGACA6ATTTCACTCTCACCATCA6CAGTCTGCAA WACITTGCTACGTACTAC 丁 GTG6TCAGGGGGTG〔TGTGGCCCCCGACGTTCG6CCAG6G6ACCAA66TG6AAA MIGT (SEQ ID NO: 1155) BMSBh-217-7 6ACATCCA6ATGACCCA6TCTCCATCCTCCCTGTCTGCATCTGTAGGA6ACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTTCTCTGTTATCTTGGTACCAGCATAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGCTTCCTT GTTGCAAAG 丁 GGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCACTCTGCAA CCTGAAGATTTT6CTACGTACTACTGTG6TCA6GGGGTGCT6TG6CCTGCGACGTTCGGCCAAGGGACCAA6GT6GAAA TCAAACGG (SEQ ID NO： 1156) BMS3H-217-8
GACATCCAGATGACCCAGTCTCCATCCTCCCT6TCTGCATCTGTAG6AGACCGTGTCACCATCACTTGCC666CAA6TC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCATAAACCAGGGAAAGCCCCTAAGCTCC 丁 GATCACHATGGTTCCTT 6TTGCAAAGTG66GTCCCATCAC6TTTCAGTGGCA6T6GATCTGGGACA6AmrCACTCTCACCATCA6CAGTCTGCAA CCTGAAC5ATTTTGCTAC(3TACTAC 丁 <3 丁 C36TCAGG(3GGTGCT(5TGGCCTGCGACGTTCGGCCAAGGGACCAAG6TGGAAA TCAAACGG (SEQ ID NO： 1157) 162· 163920.doc 201245225 BMSBh-217-9 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAG6AGACC6TGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTACTCTGTTATCTTGGIACCAGCATAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCAT GTTGCAAAGTGGGGTCCCATCACGTTrCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTTTGCAACGTACTACTGTGGTCAGG6GGTGCTGTGGCCTGCGACGTTCGGCCAA6G6ACCAA6GT66AAA TCAAAC6G (SEQ ID NO: 1158) BMS3h-217-10 GACATCCA6ATGACTCAGTCTCCATC(；TCCCT6TCTGCATCTGTA6GAGACCGA6TCACCATCACTT6CCGGGCAAGTC ATTTTAn6GTACTCTGTTATCCT66TACCAGCATAAACCA6GGAAAGCCCCTAAGCTCCTGATCACCTATG6TTCCTT GTTGCAMGTGGGGTCCCATCACGTnCAGTGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGAmTGCTACGTACTACT6r6GTCA66GA6TGCT6TGGCCT6CGACGTTCGGCCAAG6GACCAAGGTGGAAA TCAAACGG (SEQ ID NO: 1159) BMSBh-217-11 GACATCCAGATGACCCAGTCTCCATCC：TCCCTGACTeCATCTGTAGGA6ACCGTGTCACCATCACTTGCCGG6CAA6TC ATTTTAnGGTACTCTGTTATCTTGGTACCAGCATAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTT6CAAAGTGGGOTCCCATCACGTTTCAGTGGCAGT6GATCTG6GACAGAATTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTG16GTCAGGGG6TGCT6TGGCCTGC6ACGTTCGGCCAAGGGACCAAG6TGGAAA TCAAACGG (SEQ ID NO: 1160) BMS3K-217-12
AACATCCA6ATGACCCAGTCTCCATCC：TCCCT6TCTGCATCTGTAGGA<3ACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTACTCTGTTATCTTGG1ACCAGCATAAACCAGGGAAA6CCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGTGGGGTCCCATCACGTnCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CaGAAGATTTTGCTAC6TACTACT61GGTCAG6GG6TGCTGTGGCCT6CGACGTTCG6CCAAG6GACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1X61) BMS3h-217-13 GACATCCAGAT6ACCCA6TCTCCATCCTCCCTGTCTGCATCTGTAGGAGACC6T6TCACCATCAATT6CC6GGCAA6TC ATTTTATTGGTACTCTGTTATCTTGGIACCAGCATAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGTGGGGTCCCATCACGTTICAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTUGCTACGTAaACTGTGC5TCAGGGGGTGCTGTGGCCT(3CGACGTTCGGCCM6GGACCAAG6TG6AAA TCAAACGG (SEQ ID NO： 1162) BMS3h-217-14 GACATCCAGTTGACCCAGTCACCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATT66TACTCTGTTATCTTG6TACCAGCAGAAACCAG6GAAA6CCACTAA6CTCCTGATCACTTATGGTTCCTT GTT6CAAA6TGGGGTCCCATCACGTT!CAGTGGCA6TGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCT6CM CCTGAAGATTTTGCTACGTACTACTG7G6TCAGGGG6TGCT6TGGCCTCCGAC6TTC6GCCAAGG6ACCAAG6T6GAAA TCAAACGG (SEQ ID NO： 116B) BMS3H-217-15 6ACATCCAGATGACACAGTCTCCATCCTCCCTGTATGCATCTGTAG6AGACCGTGTCACCATCACTTGCC666TAA6TC ATTHATTGGTACTCTGTTATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCH GTTGCAAAGTGGGGTCCCATCACGTTICAGTGGCAGTGGATCTGGGACAGATTTCACTCTCAGCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTG1GGTCAGGGGGTGCTGTGGCCCCCGAC6TTCGGACAAGGGACCAAGGTG6AAA TCAAACAG (SEQ ID NO： 1164) 163- 163920.doc 201245225 BMSBh-217-16 GACATTCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATT66TACTCTGTTATCTTGGTACCAGCA6AAACCAAGGAAAGCCCCTAAGCTCCTGATCACTTAT6GTTCCTT GTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGT6GATCTG6GACAGATTTCACTCTCACCATCA6CA6TCTGCAA CCTGAAGATmGCTACGTACTACTGTG6TCAGG6G6TGCTGTG6CCTCC6ACGTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1165) BMSBh-217-17 6ACATCCAGATTATCCAGTCTCCATCCTCCCTTTCTGCATCTGTAGGA6ACC6TGTCACCATCACTTGCCGG6CAAGTC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGT6GATCTGGGACAGATTTCACTCTCACCATCAGCAGTCT6CAA £ATTTTGCTAC6TACTACT6TGGTCAG6G6GTGCT6TGGCCTCCGACGTTC6GCCAAGGGACCAAG6T6GAAA GG (SEQ ID NO： 1166) CCTGAAl TCAAACi
BMS3h-217-18 GACATCCAGATCACCCAGTCTCCATCCTCCCTGTCTGCATCTCTAGGAGACCGTCTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCTGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT TGG6GTCCCATCAC6TTTCA6TGGCA6TGGATCTG6GACAGATTTCACTCTCACCATCAGCAGTCTGCAA TTGCTAC6TACTACTGTGGTCAGG6GGTGCTGTGGCCTGCGACGTTCG6CCAAGGGACCAAGGTGGAAA GTTGCAAA6T CCTGAAGATT TCAAACGG (SEQ ID NO： 1167) BMS3H-217-19 6ACATCCAGATGACCCA6TCTCCATCCTCCCT6TCTGCATCT6TAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCTGAAACCAGGGAAAGCCCCAAAGCTCCTGATCACTTATGGTTCCTG 6TT6CAAA6TGGG6TCCCATCACGTTTCA6TGGCAGT66ATCTGGGACA6ATTTCACTCTCAtCATCAGCA6TCTGCAA fiATTTTGCTACGTACTACTOTGGTCAGGGGGTGCTGTGGCCTGCGACGTTCGGCCAAGGGACCAAGGTAGAAA £GG (SEQ ID NO： 1168)
CCTGAAl ACAAAC BMS3h-217-20 6ACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCT6TAGGAGACC6TOTCACCATCACTT6CCG66CAAGTC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCTTAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATCGTTCCTT 6TTGCAAC6TGG6GTCCCATCAC6TTTCAGTGGCAGTG6ATCTGG6ACA6ATTTCACTCTCACCATCAGCA6TCTGCAA CCTGAAGATTTT6CTAC6TACTACTGTGGTCAGGGGGTGCTGTGGCCTGCGACGTTCGGCCAAGG6ACCAAGGT66AAA TCAAACGG (SEQ ID NO： 1169) BMS3h-217-21 GACATCCAGATGACCCAGGCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCMGTC ATTTTATTG6TACTCTGTTATCTTG6TACCAGCT6AAACCAG6GAAAGCCCCTAAGCTCCT6ATCACTTATG6TTCCTT GTTGCA6AGTGGGGTCCCATCACGnTCAGTG6TA6TGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTTT6CTACGTACTACT6TGGTCA6GGGGTGCTGTG6CCTGCGACGTTCGGCCAAGGGACCAAGGTTGAAA ACAAACGG (SEQ ID NO： 1170) BMS3h-2X7-22 GACATCCAGATGACCCAGTCTCCATCCTCCCT6TCTGCATCT6TAGGAGACCGT6TCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTTCTCTGTTATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCAAAGCTCCTGATCACTTATGGTTCCTT 6TTGCAAAGTGGGGTCCCATCACGTTTCAGTG6CAGTGGATCTGGGACAGATTTCGCTCTCACCATCAGCAGTCTGCAA CCT6AAGATTTTGCTACGTACTACTGTGGTCAGGGGGTGCTGTGGCCTGCGACGTTCGGCCAAGGGACCAAGGTG6AAA TCAAACGG (SEQ ID NO： 1171)
163920.doc 164· 201245225 BMS3h-217-23
GTTGCAAAG CCTGAA6AT TCAAACGG GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTG6TAGTCTGTTATCTT661ACCAGGT6AAACCAG66AAAGCCCCTM6CTCCTGATCACTTATGGTTCCTT (VGTGGGGTCCCATCACGTnCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA MTTTGCTACGTACTACTG766TCAGG6GGT6CT6TGGCCT6CGAC6TTCG6CCAAGGGACAACG6TGGAAA (SEQ ID NO： 1172) BMS3h-217-24 GACATCCTGAT6ACCCAGTCTCCATCCTCCCT6TaGCATCTGTAGGA6ACC6TGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTAGTCTGTTATCTTGffTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAA6T6GG6TCCCATCACGTTTCA6TGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCT6AA6ATTTTGCTACGTACTACTGTGGTCA6GGG6TGCTGTG6CCTGCGACGTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1173) BMSBh-217-25 GACATCCAGATGACCCA6TCTCCATCCTCCCTGTCT6CATCTGTAGGA6ACC6T6TCACCATCACTTGCC6GGCAAGTC ATTTTATTGGTACTCTGGTATCTTGGTACCAGCAGAAACCGGGGAAAGCCCCTAAGCTCCTGATCAaTATGGTTCCTT GTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTG6ATCTGGGACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCTGAA6ATTTTGCTAC6TACTACTGTG6TCAGGG6GTGCTGTG6CCTGCGACGTACGGCCAAGGGACCAA6GTGGAAA TCAAACGG (SEQ ID NO: 1174) BMS3h-217-26
GACATCCAGATGACCCAGTCTCCATCCTCTCTGTCTGCATCTGTAGGA6ACC6TGTCACCATCACTTGCCG6GCAAGTC ATTTTATTGGTACTCTGGTATCTT66TACCA6CAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTAT6GTTCCTT GTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCT6AA6ATTTTGCTAC6TACTACTGTG6TCAGGGGGTGCT6TGGCCTGCGACTTTC6GCCAAGGGACCAAGGTGGAAA ACAAACGG (SEQ ID NO： 1175) BMS3h-217-27 GACATCAAGAT6ACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACC6T6TCACCATCACTTGCCG6GCGA6TC ATTrTATTGGTACTCTGGTATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCAAAGCTCCTGATCACTTATGGTTCCAT GTTGCAAA6TGG6GTCCCATCACGTTTCA6TGGCAGTG6ATCTGGGACA6ATTTCACTCTCACCATCAGCA6TCTGCAA CCT6AA6ATTTT6CTAC6TACTACTGTGGTCAGGGG6TGCT6T6GCCTGC6ACGTTCG6CCAAGGGACCAAG6TGGAAA TCAAACGG (SEQ ID NO： 1176) BMS3h-217-28 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCCTGTCACCATCACTTGCCAGGCAAGTC AmTATTGGTACTCTGGTATCCTGG 了 ACCAGCAGAAACCAGG6AAAGC(CCTAAGCTCCTGATCACTTATG(3TTCCTT GnGCAAA6T6GGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCA6TCTGCAA CCTGAAGATTTTGCTACGTACTACT6TGGTCAGGGGGTGCTGTGGCCCGCGAC6TTC6GCCAAG6GACCAAG6TGGAAA TCAAACGG (SEQ ID NO： 1177) BMS3h-217-29 GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCA6AAACCAGGGAAAGCCCCTAAGCTCCT6ATCACTTATG6TTCCTG GTTGCAAA6TGGGGTCCCATCACGTTTCAGT6GCAGTGGATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGTGGTCAGGGG6TGCTGTGGCCTGCGACGTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO: 1178) 165. 163920.doc 201245225 BMS3h-217-30
CCTGAAi TCAAAO
GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCT6CATCT6TTGGAGACCGTGTCACCATCACTT6CCGGGCAAGTC ATTnATTGGTACTCTGTTATCTTGGTACCAGCTGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGnCCTG 6TT6CAAA6TG6GGTCCCATCACGTTTCAGTGGCAGTG6ATCTG66ACAGATTTCACTCTCACCATCAGCAGTCT6CAA ^ATTTTGCTACGTACTACTGTGGTCAGGGGGTGCTGTGGCCTGCGACGTTCGGCCAAGGGACCAAGGTGGAAA 6G (SEQ ID NO： 1179) BMS3H-217-31 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATaGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCA6AAACCGG6GAAAGCCCCTAAGCTCCT6ATCACTTATG6TTCCTT GTTGCAAAGTGGGGTCCCATCACGTTTCAGTKCAGTG6ATTT666ACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTAC6TACTACTGTGGTCAGGAGGTGCT6TGGCCTGCGACGTTC6GCCAAGGGACTAA6GT6GAAA TCAAACGG (SEQ ID NO： 1180) BMS3h-217-32 GACATCCAGATGACCCAG 了 CTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCTCCATCACTTGCC6AGCAAGTC ATTTTATTGGTACTCTGTTATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATTTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATCTTGCTACGTACTACTGTGGTCAG6AG6TGCTGTGGCCTGCGACGTTCGGCCAAGG6ACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1181) BMS3h-217-33
GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCATCT6TAGGAGACCGTGTCACCATCACTT6CCAGGCAAGTC ATTTTAT 丁 GGTACTCTG 丁 TATCTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT 6TTGCAAAGTeGGGTCCCATCACGTTTCAGTG6CAGTGGATTT6G6ACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCCGAAGATTTT6CTACGTACTACT6TGGTCAGGAGGTGCTGTG6CCTGCGACGTTCGGCCAAGG6ACCAAG6T6GAAA TCAAACGG (SEQ ID NO： U82) BMS3h-217-34 6ACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCAGTAG6AGACCGT6TCACCATCACTTGCCGGGCAAGTC ATTTTAnGGTACTCT6TTATCTTG6TACCAGCA6AAACCTG6GAAAGCCCCTAAGCTCCTGATCACTTATG6TTCCTT GTTGCAAA6TGGG6TCCCATCACGTTTCAGTG6CACTGGATTTGGGACAGAATTCACTCTCACCATCGGCAGTCTGCAA CCTGAA6ATTTTGCTACGTACTACTGTGGTCA6GGGGTGCTGTGGCCTGC6ACGTTC66CCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO： 1183) BMS3h-217-35 6ACATCCAGATGACCCAGTCACCATCCTCCCT6TCTGCATCT6TAGGAGACCGTGTCACCATCACTTGCC66GCAAGTC ATnTATTGGTACTCTGnATCTTGGTACCAGCAGAAACCAGGGAAAGCCACTAAGCTCCTGATCACTTATGGTTCCTT 6TTGCAAAGT6GG6TCCCATCACGTTTCA6TGGCAGT66ATCTGG6ACAGATTTCACTCTCACCATCA6CA6TCT6CAA CCTGAAGATTTTGCTACGTACTACTGTGGTCAGGGGGTGCTGTGGCCTCCGACGTTCGGCCAAGGGACCAAGGTGGAAA TCAAACGG (SEQ ID NO: 1184) BMS3h-217-2301
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATC 丁 GTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ACnCATTGCCAGTCTGTTATCTTGGTACCAGGTGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGT6G6GTCCCATCAC6TTTCAGT66CA6TGGATCTGG<jACA6ATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTTT6CTACGTACTACT6TGGTCAGG6GGTGCTGTGGCCTGC6AC6TTC66CCAA6G6ACAAC6GTG6AAA TCAAACGG (SEQ ID NO： 1185) 166- 163920.doc 201245225 BMS3h-217-2302 GACATCCA6AT6ACCCAGTCTCCATCCTCCCTGTCT6CATCT6TAG6A6ACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTCATT6CCCAGCTGTTATCTT66TACCAG6TGAAACCAG66AAA6CCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAA6T6666TCCCATCACGTTTCA6TG6CAGTGGATCTGG6ACAGATTTCACTCTCACCATCAGCAGTCT6CAA CCTGAAGATTTTGCTACGTACTACT6TGGTCAGGGG6TGCT6T6GCCTGCGAC6TTCG6CCAAG6GACAACGGTGGAAA TCAAACGG (SEQ ID NO: 1186) BMS3h-217-2303 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTA6GA6ACCGTGTCACCATCACTTGCCG6GCAAGTC ATTTCATT6CCCAGCT6TTATCTTG6TACCA66TGAAACCAG6GAAAGCCCCTAA6CTCCTGATCACTTATGGTTCCTT GTTGCAAAGT6666TCCCATCACGTTTCAGTG6CAGTGGATCTGGGACAGATTTCACTCTCACCATCA6CAGTaGCAA CCTGAAGATTTTGCTACGTACTACTGTGGTCAGGGG6TGCT6TG6CCTGCGACGTTCG6CCAAGGGACAACGGTGGAAA TCAGACGG (SEQ ID NO： 1187) BMS3h-217-2304 GACATCCAGATGACCCAG 丁 CTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTCTCACCATCACTTGCCGGGCAAGTC ATTACATTGCCTCCCTGTTATCTT6GTACCA66TGAAACCA6GGAAAGCCCCTAA6CTCCT6ATCACTTATGGrrCCTT GTTGCA6A6TGGG6CCCCATCACGTTTCAGTG6CA6T6GATCTGGGACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCT6AAGATTTT6CTACGTACTACT6TGGTCAGGGGGTGCT6TGGCCT6C6ACGTTCGGCCAA66GACAAC6GTGGAAA TCAAACGG (SEQ ID NO: 1188) BMS3h-217-2305
6ACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCT6TAGGAGACCGTGTCACCATCACTTGCC66GCAAGTC ATTTTAnGGTAGTCTGTTATCTTGGTACCAGGTGAAACCAeGGAAAGCCCCTAAGCTCCTGATCACTTGGGCCTCCTA CTTGCAAAGTGGG6TCCCATCAC6TTrCA6T6GCAGT66ATCT6GGACAGATTTCACTCTCACCATCAGCA6TCTGCAA CCT6AA6ATTTTGCTAC6TACTACTGTGGTCAG6GG6TGCTGTG6CCT6CGAC6TTCG6CCAAGGGACAAC66TG6AAA TCAAACGG (SEQ ID NO： 1189) BMSBh-217-2306 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTGGTAGTCTGTTATCTT€ffrACCAGGT6AAACCAGG6AAA6CCCCTAAGCTCCT6ATCACTT66AC6TCCTA CTTGCAAAGTGGGGTCCCATCACGTTrCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTTTGCTAC6TACTACTGTGGTCAGG6G6T6CT6TGGCCTGC6ACGTTCG6CCAAGG6ACAACGGTGGAAA TCAAACGG (SEQ ID NO： 1190) BMS3H-217-2307 GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGA6ACCGT6TCACCATCACTT6CCG6GCAAGTC ATTTTATT6GTAGTCTGmTCTTG6TACCAGGT6AAACCAGGGAAAGCCCCTAAGCTCCT6ATCACTTGGTCGTCCTA CTTGCAAAGTGGGGTCCCATCACGTTrCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTAC6TACTACTGTGGTCAG6GGGT6CTGT6GCCTGC6ACGTTCG6CCAAGGGACAACGGTGGAAA. TCAAACGG (SEQ ID NO： 1191) BMS3h-217-2308 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTTTATTG6TAGTCTGTTATCTTGGTACCAG6T6AAACCA6GGAAAGCCCCTAAGCTCCT6ATCACTTG6GGGTCCTG 6TT6CAAAGTGGGGTCCCATCACGTTTCAGT6GCA6TGGATCT6GGACAGATTTCACTCTCACCATCAGCA6TCTGCAA CCTGAAGATTTTGCTACGTACTACTGT6GTCAG6GG6TGCTGT6GCCTGCGACGTTCG6CCAA6GGACAAC66TGGAAA TCAAACGG (SEQ ID NO： 1192) 167- 163920.doc 201245225 BMS3h-217-2309 GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCT6CATCT6TAGGAGACC6TGTCACCATCACTTGCCG66CAA6TC ATTTTATTGGTAGTCTGTTATCTTGGTACCA6GTGAAACCA6GGAAAGCCCCTAA6CTCCTGATCACTT66GC6TCCTG GTTGCAAA6TGGGGTCCCATCACGTTTCAGTGGCAGTGGATCT6G6ACAGATTTCACTCTCACCATCAGCAGTC V^GATTTTGCTACGTACTACTGTGGTCAGGGGGTGCTGTGGCCTGCGACGTTCGGCCAAGGGACAACGGTG C66 (SEQ ID NO： 1193)
CCT6AAG TCAAACG
TCTGCAA 3TGGAAA BMS3h-217-2310 GACATCCA6ATGACCCAGTCTCCATCGrCCCT6TCTGCATCT6TAGGAGACC6T6TCACCATCACTT6CCG66CAAGTC ATTTTATT6GTAGTCT6TTATCTTGGTACCAGGTGAAACCAGGGAAA6CCCCTAA6CTCCT6ATCACTT6GAGCTCCTG 6TT6CAAA6TGG6GTCCCATCACGTTTCAGTGGCAGTGGATCT6GGACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCTGAA6ATTTTGCTACGTACTACTGTG6TCAGGG6GTGCTGTGGCCT6CGAC6TTCGGCCAA66GACAAC6GTGGAAA TCAAAC66 (SEQ ID NO: 1194) BMS3h-217-2311 GACATCCAGATGACCCAGTC 丁 CCATCCTCCCTGTCTGCATCTGTAGGAGACCCTGTCACCATCAC 丁 TGCCGGGCAAGTX ATT6GATT6CCCAGCTGTTATCTTGGTACCAGGT6AAACCAGG6AAAGCCCCTAAGCTCCTGATCACTTAT66TTCCTT GTTGCAAA6T6GG6TCCCATCACGTTTCAGTGGCAGT6GATCTGGGACA6ATTTCACTCTCACCATCA6CAGTCTGCAA CCTGAAGATTTT6CTAC6TACTACTGTGGTCAGGGGGTGCTGTGGCCTGCGAC6TTCG6CCAA6GGACAACGGTGGAAA TCAAACGG (SEQ ID NO： 1195) BMS3h-217-2312 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCT6CATCT6TAGGAGACCGTGTCACCATCACTT6CCG66CAAGTC ATTTTATTG6TTCGCTCTTAC6CTGGTACCAGGTGAAACCAGGGAAAGCCCCTAAGCTCCT6ATCACTTATG6TTCCTT GTTGCAAAGT6GGGTCCCATCACGTTTCAGTGGCA6TG6ATCT666ACA6ATTTCACTCTCACCATCA6CA6TCTGCAA CCTGAAGATTTTGCTACGTACTACTGT6GTCAGGGGGT6CTGTGGCCTGC<jACGTTCGGCCMG6GACAACG6T66AAA TCAAACGG (SEQ ID NO： 1196)
BMS3h-217-2313 GACATCCAGATC5ACCCAGTCTCCATCCTCCCT6TCT6CATCTGTAGGAGACC6T6TCACCATCACTTGCC66GCAA6TC ATCGGATTGCCCAGCTGTTATCTTGGTACCAGGTGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT 6TTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCA6TCT6CAA CCTGAAGATTTTGCTAC6TACTACT6TGGTCA6G6GGTGCTGTGGCCT6CGAC6TTC66CCAAG6GACAAC6GTG6AAA TCAAACGG (SEQ ID NO： 1197) BMS3h-217-2B14 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCT6TA66A6ACCGTGTCACCATCACTTGCCGG6CAAGTC ATTACATTGCCTCCCTGTTATCTTGGTACCAGGTGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT OTTGCAAAGTGGGGTCCCATCACGmCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTACGTACTACT6TGGTCAGGGG6TGCTGTGGCCTGCGACGTTCGGCCAAGG6ACAACG6TGGAAA TCAAACGG (SEQ ID NO: 1198) BMS3h-217-2B15 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCG66CAA6TC ATTTTATTGGTA6TCTGTTATCTT66TACCAGGTGAAACCAGGGAAAGCCCCTAAGCTCCTGATCCG6TTC6GCTCCTT 6TTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACA6ATTTCACTCTCACCATCAGCA6TCTGCAA CCTGAAGATTTTGCTACGTACTACTGT6GTCAGGGGGTGCTGTG6CCTGCGACGTTCGGCCAA6GGACAACGGTGGAAA TCAAACGG (SEQ ID NO: 1199)
163920.doc 168- 201245225 BMS3h-217-2316 6ACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTA66A6ACCGT6TCACCATCACTTGCC6GGCAA6TC ATTTTATT66TAGTCT6TTATCTT6G1*ACCAG6T6AAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTACAAGTCCTA CTT6CAAAGTGGGGTCCCATCAC6TTTCAGTG6CAGT6GATCT6GGACA6ATTTCACTCTCACCATCAGCA6TCTGCAA CCTGAAGATTTTGCTACGTACTACTGTGGTCAGGG6GT6CTGTGGCCT6C6ACGTTC6GCCAAGGGACAAC6GTGGAAA TCAAACGG (SEQ ID NO： 1200) BMS3h-217-2317 6ACATCCAGAT6ACCCAGTCTCCATC<：TCCCT6TCT6CATCT6TAG6AGACC6TGTCACCATCACTTGCCGGGCAAGTC ATTTTATT6GTAGTCTGTTATCTT661ACCAG6T6AAACCAGGGAAAGCCCCTAAGCTCCTGATCACTT6GG6CTCCTA CTTGCAAA6TG666TCCCATCACGTnCAGTG6CAGTGGATCTGGGACAGATTTCACTCTCACCATCA6CAGTCTGCAA CCTGAAGATTTTGCTACGTACTACTGIGGTCAGGGGGTGCTGTGGCCTGCGACGTTCGGCCAAGGGACAACGGTGGAAA TCAAACGG (SEQ ID NO： 1201) BMS3h-217-2318 GACATCCAGATGACCCA6TCTCCATCCTCCCTGTCT6CATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAA6TC ATTTTATITGGGGGCCCTTATCTTGGTACCAGGTGAAACCAGGCSAAAGCCCCTAAGCTCCTGATCACHATGGTTCCT 丁 GTTGCAAAGTGGGGTCCCATCACGTnCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6ATTCT6CTAC6TACTACTG7GGTCAGGGGGTGCTGTGGCCT6CGACGTTCGGCCAAGG6ACAACGGTGGAAA TCAAACGG (SEQ ID NO： 1202) BMSBh-217-2319
GACATCCA6ATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTC ATTGGATTGCCACCCTGTTATCTTGGTACCA6GTGAAACCAG6GAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAAGTGGGG 丁 CCCATCACGTTTCAGTGGCAGTGGATC 丁 GGGACAGATTTCACTCTCACCATCAGCAGTCTiSCAA CCTGAAGATTTTGCTACGTACTACTGTGGTCAGGGGGTGCTGTGGCCT6CGAC6TTCGGCCAAGGGACAACGGTGGAAA TCAAACGG (SEQ ID NO: 120B) BMS3h-217-2320 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGA6ACCGTGTCACCATCACTTGCC6GGCAAGTC ATTTTATTTGGGGGCCCTTATCTTGGTACCAGGTGAAACCAGGGAAAGCCCCTAAGCTCCTGATCACTTATGGTTCCTT GTTGCAAA6TGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAAGATTTT6CTACGTACTACTGTGGTCAG6GGGT6CTGT6GCCTGCGACGTTCGGCCAAGGGACAACGGTGGAAA TCAAACGG (SEQ ID NO； 12Θ4) BMS3h-217-2321 GACATCCA6ATGACCCA6TCTCCATCCTCCCTGTCT6CATCTGTAG<3AGACC6TGTCACCATCACTr6CC6GGCAAGTC ATTTTATTGGTAGCCTCTTAAACT6GT^CCA6GTGAAACCA6G6AAAGCCCCTAA6CTCCT6ATCACTTATGGTTCCTT GTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAA CCTGAA6A7TTTGCTACGTACTACT6T36TCAGGGGCT6CTGT66CCT6CGAC6TTC66CCAAGGGACAACGGTGGAAA TCAAACGG (SEQ ID NO: 120S) BMS3h-217-2322 GGCATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGA6ACCGTGTCACCATCACTTGCC6G6CAA6TC ATTmTTGGTAGTCTGTTATCTTGGTACCAGGTGAAACCAGGGAAAGCCCCTAAGCTCaGATCACTTACGGGTCCTG GTTGCAAACTGG<3GTCCCATCACGTTT:AGTGGC：AGTGGATCT66GACAGATTTCACTC 丁 CACCATCAGCAGTCTGCAA CCTGAAGATTTTGCTAC6TACTACTGT<3GTCAGGG6GTGCT6TGGCCTGC6ACGTTCGGCCAAGGGACAACGGTG6AAA TCAAACGG (SEQ ID NO： 12Θ6) 實例1 經由BMS3h-225產生人類抗CD40可變域BMS3h-l 以下實例描述經由BMS3h-225產生一系列命名為BMS3h-1之抗人類CD40可變域。在噬菌體表面上重組表現單一免 疫球蛋白可變域譜系之後，藉由使噬菌體譜系與固定目標 抗原接觸，洗滌以移除未結合之噬菌體且傳播結合之噬菌 -169- 163920.doc 201245225 體來進行選擇。此方法通常稱為「淘選」。其適用於筛檢 單一免疫球蛋白可變域以及可在呈現文庫上表現之其他抗 體片段，例如scFv、Fab及Fab’。或者，可藉由針對僅藉由 指叠成員結合之固定通用配位體（例如蛋白質A或蛋白質l) 淘選來預先選擇表現適當摺疊之成員變異體之噬菌體。此 有如下優勢：降低非功能成員之比例，由此增加可能結合 目標抗原之成員的比例。舉例而言，WO 99/20749中教示 用通用配位體進行預先選擇。舉例而言，Harrison等人， Ewg/wo/. 267: 83-109 (1996)大體描述 了噬菌體抗體 文庫之篩檢。 篩檢通常使用固定於固體支撐物（例如塑膠管或孔）或層 析基質（例如SepharoseTM (Pharmacia))上之純化抗原來執 行。篩檢或選擇亦可在諸如細胞表面之複合抗原上執行 (Marks等人，11: 1145 (1993) ; de Kruif等 人，/Voc. JcaA 5W· C/M 92: 3938 (1995))。另一替 代方法涉及藉由結合溶液中之經生物素標記之抗原來選 擇’隨後捕捉於塗佈抗生蛋白鏈菌素之珠粒上。 純系 BMS3h-l 至 BMS3h-69 ·· 使用遞減濃度之抗原（第1輪100 nM ;第2輪1 ο nM ;第3 輪1 nM)針對經生物素標記之人類CD40單體（由BMS供應， 每莫耳CD40 1.5莫耳生物素）與經生物素標記之人類CD40-Ig(由BMS供應，每莫耳CD40-Ig3.3莫耳生物素）並行進行 二輪選擇。在起始選擇之前，如下組合來自未處理4G及 6G Domantis dAb文庫之嗤菌體： 163920.doc •170· 201245225 1) 4G+6G VH CDR:3長度在7至9個胺基酸之間。 2) 4G+6G VH CDR:3長度在10至12個胺基酸之間。 3) 4G+6G VH CDR:3長度在13至15個胺基酸之間。
4) 4G VK
5) 6G VK 各輪選擇涉及將所要濃度之抗原添加至750 μΐ來自未處 理文庫池之一之噬菌體或後續選擇輸出之噬菌體與750 μΐ PBS+2% Marvel (含有 2% (w/v) Marvel [Premier Foods, UK]之磷酸鹽緩衝鹽水）之混合物中且在室溫下藉由翻滾混 合來培育1小時。接著藉由添加1〇〇 μΐ再懸浮Dynabeads® M-280抗生蛋白鏈菌素[Invitrogen，UK]來捕捉經生物素標 記之抗原噬菌體複合物，且在室溫下藉由翻滚混合來培育 5分鐘。接著使用KingFisher磁力分離器[Thermo Fisher Scientific，UK]回收 Dynabeads®且用 7x1 ml PBS+0.1%吐溫 20 (含有0.1% (v/v)聚氧乙烯脫水山梨糖醇單月桂酸酯 [Sigma-Aldrich，UK]之PBS，PBST)，隨後用 lxl ml PBS洗 滌。藉由與500 μΐ胰蛋白酶-PBS (50 μΐ溶解於5〇111]^1'出-HCl(pH 7.4)、1 mM CaCl2 中之 1〇 mg/ml胰蛋白酶[Sigma-Aldrich，UK]添加至450 μΐ PBS中）一起培育來溶離保留在 經洗滌Dynabeads®上之結合噬菌體。回收含有噬菌體之溶 液，且在37°C下使用250 μΐ感染1.75 ml對數生長期大腸桿 菌（五· co/ί) TG1 (〇1)600為0.4)30分鐘。在微量離心機中在 11,600 g下離心大腸桿菌TG1噬菌體感染之培養物1分鐘。 使所得細胞集結粒再懸浮於1 ml 2xTY (1公升中有16 g胰 163920.doc -171- 201245225 蛋白腺、10 g酵母萃取物及5 g NaCl，在1211：下用高壓爸 處理15分鐘）中且接種於含有補充有15 pg/rnl四環素之TY 的9 cm皮式培養皿（petri dish)上。在37°C下培育培養盤隔 夜。接著將2 ml補充有15%甘油之2xTY添加至各培養盤 中，並用玻璃散佈器分散該等細胞且充分混合。使用5〇 μ1 刮落細菌接種50 ml補充有15 pg/ml四環素之2χΤΥ，且在 37°C下在250 rpm振盪下生長隔夜。在3,300 g下離心隔夜 培養物15分鐘以集結細菌。為了沈澱析出噬菌體，將1〇 ml PEG/NaCl (20%聚乙二醇 8000，2.5 M NaCl)添加至 40 ml上清液中》混合噬菌體/PEG溶液且靜置於冰上1小時， 接著在4°C下在3,300 g下離心30分鐘，且去除上清液。使 集結粒再懸浮於2 ml PBS中且在微量離心機中在u/oo g 下離心10分鐘’移除剩餘細菌碎片。含有噬菌體之所得上 清液接著用於下一輪針對適當經生物素標記之CD40抗原 之選擇。 在第2輪及第3輪選擇之後’進行單株噬菌體ELISA。使 用3次250 μΐ PBST之洗滌，隨後3次250 μΐ PBS之洗滌執行 所有洗滌。在4°C下，用每孔50 μΐ 1 Rg/ml中性鏈親和素
(Thermo Scientific, UK)於0.2 Μ碳酸鹽-碳酸氫鹽緩衝液 (pH 9.4)中之混合物塗佈培養盤隔夜。洗滌培養盤，且接 者在至溫下用2% MPBS (含2% w/v Marvel脫脂奶粉 [Premier Foods]之PBS)阻斷1小時。接著洗滌培養盤且與 每孔50 μΐ 0.7 pg/ml經生物素標記之人類CD40於2% MPBS 中之混合物一起培育。洗滌培養盤’且將噬菌體上清液添 163920.doc •172· 201245225 加至等體積之2% MPBS中》接著在室溫下培育培養盤1小 時。洗滌培養盤且用用2% MPBS以1:5000稀釋之抗Ml3-HRP結合物（GE Healthcare，UK)偵測結合噬菌體，且在室 溫下培育1小時。洗滌培養盤，且使用SureBlue單組分 TMB MicroWell過氧化酶溶液（KPL Inc，USA)進行ELISA顯 色。藉由與塗有中性鏈親和素但無生物素標記CD40之培 養盤相比較來鑑別特異性噬菌體。使用MidiPrep自 pDOM4(Domantis)第:2輪及第3輪輸出分離dAb V-基因，且 選殖至pDOM5 (Domantis)中。WO 2007/085815 中所揭示 之pDOM4為Fd噬菌體載體之衍生物，其中基因ΙΠ信號肽 序列經酵母酿脂錫定表面蛋白（yeast glycolipid anchored surface protein，GAS)信號肽置換（WO 2005/093074)。 pDOM4亦在前導序列與基因III之間含有c-myc標籤，此將 基因III放回框架中。 如下鑑別結合dAb。在37°C下，在Costar 96孔細胞培養 集群（Corning Incorporated, USA)中在 250 rpm 振盪下自各 輸出選取96個個別菌落（於pDOM5中）至200 μί含有OnEx自 體誘導介質（Novagen，UK)之Terrific培養液中隔夜。離心 培養物以集結細胞，且藉由CD40結合dAb之抗原結合 ELISA分析上清液。在4°C下用每孔50 μΐ 1 Hg/ml中性鏈親 和素於0.2 Μ碳酸鹽碳酸氫鹽緩衝液（pH 9.4)中之混合物 塗佈MaxiSorp 96孔免疫培養盤（Nunc, USA)隔夜。所有洗 滌係如噬菌體ELISA所述。在室溫下用200 μΐ含有1%吐溫 20之PBS阻斷培養盤1小時。接著洗滌培養盤且與每孔50 163920.doc •173· 201245225 μΐ 0.7 pg/ml經生物素標記之人類CD40於0.1% MPBS中之 混合物一起培育。將澄清之含有dAb之培養物上清液添加 至具有等體積0.1% PBS之TELISA培養盤中。在室溫下培 育培養盤1小時且接著洗滌。使用兩步方法偵測結合dAb : 首先在室溫下添加用0.1°/〇 PBST以1:2000稀釋之9E10 (抗 myc IgG，Sigma-Aldrich，UK)持續1小時，接著洗蘇，隨 後在室溫下添加用0.1% PBST以1:2000稀釋之抗小鼠Fc-HRP (Sigma-Aldrich，UK)持續1小時。洗滌培養盤，且使 用SureBlue單組分TMB MicroWell過氧化酶溶液（KPL Inc, · USA)進行ELISA顯色。允許顯色，且藉由添加等體積1 Μ HC1中止比色反應《在450 nm下讀取ELISA培養盤。藉由 與塗有中性鏈親和素但無生物素標記CD40之培養盤相比 較來鑑別特異性噬菌體。 在基於珠粒或基於ELISA之受體結合分析（receptorbinding assay ， RBA) 中 測試對 CD40具特異 性之純 系以評 估CD40配位體結合之抑制。在B細胞增殖分析中，且接著 在多種其他活體外細胞分析中測試在RB Α中顯示抑制作用 鲁 之域抗體。下文更詳細描述此等分析。 BMS3h-l〇6MBMS3h-225 ： BMS3h-l〇6至BMS3h-225係自針對如關於BMS3h-l至 BMS3h-69所述但具有以下修飾之生物素標記CD40或生物 素標記CD40-FC之選擇來分離。在起始選擇之前，如下組 合來自未處理4G及6G文庫之噬菌體： 6) 4G VH CDR3長度在7至9個胺基酸之間。 163920.doc •174· 201245225 7) 4G VH CDR3長度在10至12個胺基酸之間。 8) 4G VH CDR3長度在13至15個胺基酸之間。 9) 6G VH CDR3長度在7至9個胺基酸之間。 10) 6G VH CDR3長度在10至12個胺基酸之間。 11) 6G VH CDR3長度在13至15個胺基酸之間。
12) 4GVK
13) 6GVK 對於CD40-FC在160 nM之抗原濃度下執行第1輪，且對 於CD40在100 nM下執行。輸出效價在2·〇χ104至9.〇xl07 TU/ml之範圍内（功能病毒效價）。 對於第2輪，來自第1輪之富集噬菌體在用於選擇之前被 成對組合： 1) 4G+6G VH CDR3長度在7至9個胺基酸之間（來自第1輪 之池1 +池4)。 2) 4G+6G VH CDR3長度在10至12個胺基酸之間（來自第1 輪之地2 +池5)。 3) 4G+6G VH CDR3長度在13至15個胺基酸之間（來自第1 輪之池3 +池6)。 4) 4G+6G VK (來自第1輪之池7 +池8) 在100 nM之抗原濃度下進行選擇，且使用與中性鏈親和素 (Thermo Fisher ScientiHc, UK)偶合之 M-280 曱苯項醯基活 化Dynabeads® (Invitrogen)捕捉抗原-嗟菌體複合物。輸出 效價在 6.5xlO7 TU/ml至7.5xlO8 TU/ml之範圍内。 在20 nM之抗原濃度下且在CD40-Fc選擇之情況下，在 163920.doc -175- 201245225 6.7 μΜ游離人類Fc尾（BMS)存在下執行第3輪。輸出效價在 4.3xl07TU/ml 至1.6xl09TU/ml 之範圍内。 如關於第2輪所述但在2 nM之抗原濃度下且在存在及不 存在500倍過量未標記CD40-FC之情況下執行第4輪。在最 初使噬菌體與生物素標記抗原一起培育1小時之後添加此 競爭劑，且接著如前所述培育混合物隔夜。包括此競爭步 驟，目的在於增強對具有較慢解離速率之dAb之選擇。在 無競爭之情況下輸出效價在1.8><107丁11/1111至4.4><1071'1；/1111 之範圍内，且在有競爭之情況下在1.8xl06 TU/ml至 2.3xl07 TU/ml之範圍内。 為了監測選擇之進展，在第2輪及第3輪之後進行單株噬 菌體ELISA。如關於BMS3h-l至BMS3h-69所述執行此等操 作。如關於BMS3h-l至BMS3h-69所述鑑別結合dAb，其中 例外為在VK文庫篩檢之情況下，包括最終濃度為0.8 pg/ml之蛋白質L。添加蛋白質L會藉由使dAb交聯而增加 信號強度。 BMS3h-70至 BMS3h-105 ·· BMS3h-70至BMS3h-105係自針對已被動吸附至免疫管之 抗原的選擇來分離。在起始選擇之前，如下組合來自未處 理4G及6GDomantisdAb文庫之嗤菌體： 1) 4G VH CDR3長度在7至9個胺基酸之間。 2) 4G VH CDR3長度在10至12個胺基酸之間。 3) 4G VH CDR3長度在13至15個胺基酸之間。 4) 6G VH CDR3長度在7至9個胺基酸之間。 163920.doc -176- 201245225 5) 6G VH CDR3長度在10至12個胺基酸之間。 6) 6G VH CDR3長度在13至15個胺基酸之間。
7) 4G VK
8) 6G VK 對於第一輪選擇，將1 ml 10 pg/ml人類CD40-FC融合物 (BMS)於0.2 Μ碳酸鹽-碳酸氫鹽緩衝液（PH 9.4)中之混合物 添加至Nunc MaxiSorp免疫管中且接著在4°C下，在滾動下 培育隔夜。接著排空該管且用磷酸鹽緩衝鹽水（PB S)洗滌 三次。接著藉由用MPBS填充至滿且在室溫下培育1小時來 阻斷該管。接著排空該管且用PBS洗滌三次。將含文庫噬 菌體之4 ml MPBS添加至該管中且在室溫下，在旋轉翻滾 下培育1小時。 排空該管且用PB_ST (具有0.1% (v/v)吐溫20之PBS)洗滌 1 〇次。在室溫下’藉由在旋轉翻滾下與50〇 4丨胰蛋白酶- PBS (50 μΐ溶解於 50 mM Tris-HCl (pH 7.4)、1 mM CaCl2 中 之 10 mg/ml胰蛋白酶[Sigma-Aldrich，UK]添加至 450 μΐ PBS中）一起培育1〇 min來溶離保留在經洗滌管上之結合噬 菌體。回收含有噬菌體之溶液，且在37t下使用250 μΐ感 染1.75 ml對數生長期大腸桿菌TGI (OD600為0.4)30分鐘。 在微量離心機中在11,600 g下離心大腸桿菌TG1噬菌體感 染之培養物1分鐘’且使所得細胞集結粒再懸浮於1 ml 2xTY (1公升中有16 g胰蛋白腺、1〇 g酵母萃取物及5 g NaCl，該懸浮液在121°C下以高壓釜處理15分鐘）中且接種 於含有補充有15 pg/ml四環素之LB瓊脂之9 cm皮式培養皿 163920.doc •177· 201245225 中。在37C下培育培養盤隔夜。接著將2 ml補充有15〇/〇甘 油之2xTY添加至各培養盤中，且用玻璃散佈器分散該等 細胞且充分混合。 使用50 μΐ刮落細菌接種5〇 ml補充有15 環素之 2xTY ’且在37°C下在250 rpm振盪下生長隔夜。在3,3〇〇 g 下離心隔夜培養物15分鐘以集結細菌。為了沈澱析出噬菌 體’將10 ml PEG/NaCl (20%聚乙二酵 8000，2.5 μ NaCl) 添加至40 ml上清液中。混合噬菌體/peg溶液且靜置於冰 上1小時。接著在4。〇下在3，3 00 g下離心溶液3〇分鐘，且去 除上清液。使集結粒再懸浮於2 mi PBS中且在微量離心機 中在11，600 g下離心1〇分鐘’移除剩餘細菌碎片。含有噬 菌體之所得上清液接著用於下一輪針對CD40-FC抗原之選 擇。第1輪之輸出效價在7.5xl04 TU/ml至1.5xl07 TU/ml之 範圍内（每毫升之感染單位）。 使用自第一輪選擇回收之富集噬菌體執行第二輪選擇。 如上所述精確執行此操作且輸出效價在2.5x1 〇7 TU/ml至 1.2><108 TU/ml之範圍内。 使用自第二輪選擇回收之富集噬菌體執行第三輪選擇。 如上所述但在1 pg/ml之抗原濃度下執行此等操作。輸出效 價在 5.1 xlO7 TU/ml至 7.5xl0s TU/ml之範圍内。 為了監測選擇之進展，在第2輪及第3輪之後進行單株嗟 菌體ELISA。將個別菌落之樣品選取至200 pL補充有15 Kg/ml®環素之2xTY中’且在37°C下，在Costar 96孔細胞 培養集群（Corning Incorporated，USA)中在250 rpm振盎下 163920.doc •178· 201245225 培育隔夜。離心培養物以集結細胞，且藉由CD40結合嗤 菌體dAb之抗原結合ELISA分析上清液。使用3次250 μΐ PBST之洗滌’隨後3次250 μΐ PBS之洗滌執行所有洗滌。 在 4°C 下用每孔 50 μΐ 0.5 pg/ml CD40-Fc (BMS)於 0·2 Μ碳 酸鹽-碳酸氫鹽緩衝液（pH 9.4)中之混合物塗佈MaxiSorp 96 孔免疫培養盤（Nunc: USA)隔夜。洗滌培養盤，且接著在 室溫下用250 μΐ 2% MPBS阻斷1小時》洗滌培養盤，且將 嗤菌體上清液添加至等體積2% MPB S中且在室溫下培育1 小時。洗滌培養盤且用用2% MPBS以1:5000稀釋之抗Ml 3-HRP結合物（GE Healthcare，UK；H貞測結合嗤菌體，且在室 溫下培育1小時。洗滌培養盤，且使用SureBlue單組分 TMB Micro Well過氧化酶溶液（KPL Inc，USA)進行ELISA顯 色。藉由與塗有游離Fc之培養盤相比較來鑑別特異性噬菌 體 dAb。 將來自以上第2輪及第3輪選擇輸出中之每一者之dAb基 因以池形式次選殖至大腸桿菌菌株HB2151中之可溶性表 現載體pDOM5中。此載體允許在大腸桿菌中表現具有c-myc標籤之游離dAb(Roche Diagnostics GmbH)且分泌至上 清液中。 如下鑑別來自被動選擇之CD40結合dAb。在37°C下，在 Costar 96孔細胞培養集群（Corning Incorporated，USA)中在 25 0 rpm振盪下自各輸出選取96個個別菌落（於pD0M5中） 至200 pL含有OnEx〖3體誘導介質（Novagen，UK)之Terrific 培養液中隔夜。離心培養物以集結細胞，且藉由CD40結 163920.doc -179- 201245225 合dAb之抗原結合ELISA分析上清液。在4°C下用每孔50 μΐ 0.5 pg/ml CD40-Fc (BMS)於0.2 Μ碳酸鹽-碳酸氫鹽緩衝液 (卩119.4)中之混合物塗佈]\^乂丨8〇印96孔免疫培養盤（1''11111(^ USA)隔夜。所有洗滌係如噬菌體ELISA所述。在室溫下用 250 μΐ含有1%吐溫20之PBS (PBST)阻斷培養盤1小時。將 澄清之含有dAb之培養物上清液添加至具有等體積0.1% PBST之ELISA培養盤中。在室溫下培育培養盤1小時且接 著洗滌。使用兩步方法偵測結合dAb :首先在室溫下添加 用0.1% PBST以1:5000稀釋之生物素標記9E10 (抗myc · IgG，Sigma-Aldrich，UK)持續1小時，接著洗滌，隨後在 室溫下添加用0.1% PBST以1:5000稀釋之抗生蛋白鏈菌素-HRP (Bender MedSystems，Austria)持續 1小時。洗滌培養 盤且使用SureBlue單組分TMB進行ELISA顯色》藉由與塗 有游離Fc之培養盤相比較來鑑別特異性dAb。 在基於珠粒或基於ELISA之受體結合分析（RBA)中測試 對CD40具特異性之純系以評估CD40配位體結合之抑制》 表5中給出自RBA獲得之效能量測（初步篩檢工作）。在B細 籲 胞增殖分析中，且接著在多種其他活體外細胞分析中測試 在RB A中顯示抑制作用之域抗體。
BMS3h-210MBMS3h-22S BMS3h-210至BMS3h-225係自針對完整細胞之選擇來分 離。在起始選擇之前，如下組合來自未處理4G及6G DomantisdAb文庫之嗤菌體： 1) 4G+6G VH CDR3長度在7至9個胺基酸之間。 163920.doc • 180 · 201245225 2) 4G+6G VH CDR3長度在10至12個胺基酸之間。 3) 4G+6G VH CDR3長度在13至15個胺基酸之間。
4) 4G and 6G VK 在第1輪中，將用細胞表面表現之人類CD40 (由BMS供 應）穩定轉染之DG44 CHO細胞株用作抗原。在針對此等細 胞作選擇之前，使上文所述之文庫池與未經轉染之CHO細 胞一起培育以去除其對除CD40以外之細胞表面抗原具特 異性之噬菌體呈現dAb。藉由在評估存活力之前與凡爾生 (Versene)(Invitrogen) —起培育來收集兩種類型之細胞。使 六百萬個活的未經轉染之CHO細胞再懸浮於4 ml具有2% (w/v)BSA之PBS (PBS/BSA)中且在4°C下旋轉翻滾1小時以 進行阻斷。除非另外說明，否則在4°C下執行所有後續步 驟。在185 g下離心細胞5分鐘，且將含有經去除之文庫噬 菌體之上清液轉移至新鮮管中。向此管中添加含6x106個 活CHO-CD40細胞之1 ml PBS/BSA，且旋轉混合物1小時。 接著藉由在185 g下離心5分鐘來洗滌該等細胞5次，且再 懸浮於10 ml PBS/BSA中。在最終洗滌後，如先前集結細 胞且接著再懸浮於〇·ί; ml 1 mg/ml牛胰腺之XIII型胰蛋白酶 (Sigma Aldrich，UK)於補充有 5 mM Tris-HCl (pH 7.4)、0.1 mM CaCl2之PBS中的混合物中，且轉移至微量離心管中。 在室溫下旋轉細胞10分鐘，隨後在16000 g下離心5分鐘。 使用上清液中之溶離之嗤菌體感染大腸桿菌，且輸出喧菌 體效價經測定在5.1xl05 TU/ml與2.7xl06 TU/ml(每毫升之 感染單位）之間。 163920.doc -181 - 201245225 使用自第一輪選擇回收之富集噬菌體執行第二輪選擇。 如上所述但無初始去除（去選擇）步驟且使用RAMOS人類B 細胞（ATCC)替代CHO-CD40來執行此等操作。輸出效價在 2.3xl05TU/ml至 7.5xl05TU/ml之範圍内。 如第二輪般執行第三輪選擇《輸出效價在1.9x108 TU/ml 至3_5xl08TU/ml之範圍内。 將來自以上第2輪及第3輪選擇輸出中之每一者之dAb基 因以池形式次選殖至大腸桿菌菌株HB2151中之可溶性表 現載體PDOM5中。此載體允許在大腸桿菌中表現具有c-myc標籤之游離dAb且分泌至上清液中。 在CHO細胞受體結合分析（RBA)中測試對CD40具特異性 之純系以評估CD40配位體結合之抑制。在B細胞增殖分析 中，且接著在多種其他活體外細胞分析中測試在RB A中顯 示抑制作用之域抗體。 藉由易錯PCR進行親和力成熟 構築13個在下文實例6中所述之B細胞增殖分析中顯示中 和活性之BMS3h dAb的易錯噬菌體文庫（參見表17)。此係 藉由使用Mutazyme II聚合酶（來自Agilent Technologies之 GeneMorph II套組之一部分）在擴增期間藉由聚合酶鏈反應 (PCR)將錯誤任意引入dAb基因中來執行。在GAS1前導序 列控制下將突變dAb基因以與W噬菌體基因III蛋白質之基 因融合物形式選殖至pDOM4載體中，該載體含有為產生感 染性噬菌體粒子所必需之所有fd基因。此等文庫之尺寸為 約1χ108個CFU (菌落形成單位），每個dAb基因之錯誤率為 163920.doc -182- 201245225 2至5個胺基酸。 使由此等文庫產生之噬菌體經受三輪針對可溶性生物素 標記人類CD40之選擇。第一輪噬菌體選擇係藉由將噬菌 體文庫與2% MPBS (補充有2% (w/v) Marvel乾脫脂奶粉之 填酸鹽緩衝鹽水）預混合且添加生物素標記人類CD40 (BMS)至最終濃度為於1 mi之最終體積中2〇 nM來執行。在 室溫下’在翻滾混合下培育混合物至少1小時。接著使用 50 μΐ M-280抗生蛋白鏈菌素Dynabeads® (Invitrogen)捕捉 抗原·噬菌體複合物且用1 ml PBST洗滌7次，隨後用1 ml PBS洗務一次。藉由興〇·5 ml 1 mg/ml來自牛騰腺之ΧΠΙ型 姨蛋白酶（Sigma Aldrich，UK)於補充有 5 mM Tris-HCl (pH 7.4)、0.1 mM CaCl2之PBS中的混合物一起培育而自抗原/ 珠粒複合物溶離洗滌之噬菌體。使用溶離之噬菌體感染大 腸桿菌’且輸出嗔菌體效價經測定在2x 1 〇5 τυ/ml與9 X 107 TU/ml(每毫升之感染單位）之間。
使用自第一輪選擇回收之富集噬菌體用最終濃度之2 nM 生物素標記CD40執行第二輪選擇，隨後如上所述使用抗 生蛋白鏈菌素珠粒捕捉。輸出效價在3Χι 〇4 τυ/ml至5x106 TU/ml之範圍内。 使用2 nM生物素標記CD40進行第三輪選擇，隨後使用 抗生蛋白鏈菌素珠粒捕捉》溶離之噬菌體效價在8 χ i 〇4 TU/ml 至 4xl06 TU/ml 之範圍内。 BIAcoreTM 篩檢 將來自以上第3輪選擇輸出各自之dAb基因以'池形式次選 163920.doc •183- 201245225 殖至大腸桿菌HB2151中之可溶性表現載體pDOM13 (Domantis)中。pDOM13載體亦稱為pDOM33且揭示於 WO/2008/149143中。此載體允許在大腸桿菌中表現游離 dAb且分泌至上清液中。在37°C下，在Costar 96孔細胞培 養集群（Corning Incorporated, USA)中在 250 rpm振盪下自 各輸出選取47個個別菌落且在200 μΐ含有Novagen隔夜表現 自體誘導介質（Merck Chemicals，UK)之 Terrific 培養液（TB) 中表現隔夜。在相同培養盤中，用表現適當親本（野生型） dAb之大腸桿菌接種單一孔。離心培養物以集結細胞，且 鲁 用BIAcoreTM 3000儀器（GE Healthcare)篩檢上清液與親本 dAb相比「解離速率」（亦即解離速率常數，幻）之改良》 將約1600個反應單位（RU)之生物素標記人類CD40 (BMS)固定於抗生蛋白鏈菌素（SA) BIAcoreTM晶片之一個 流槽上。將未固定有任何配位體之第二流槽用作參比流槽 進行線内參比。用HBS-EP緩衝液（具有0.15 M NaCM、3 mM EDTA及 0.005% v/v界面活性劑P20 之 0.01 M HEPES (pH 7.4)，GE Healthcare)以1:3稀釋各待分析之dAb上清 _ 液。使用儀器之KINJECT功能將10微升各dAb上清液注射 於串聯之固定CD40之流槽及參比流槽上，線内減去來自 參比槽之信號。在25°C及10 μΐ/min之HBS-EP流速下執行 實驗。各注射完成後，允許在緩衝液中自配位體解離dAb 120秒，隨後由注射5 μΐ 10 mM甘胺酸（pH 2.0)而再生。使 用BIAevaluation 4.1軟體（GE Healthcare)自各分析物跡線 減去參比流槽跡線。使用同一軟體來近似擬合分析物跡線 163920.doc •184- 201245225 之解離階段的1:1 (朗谬爾（Langmuir))動力學模型。此模型 產生各純系之近似解離速率常數（「解離速率」或A:d)且允 許與野生型dAb進行相對比較。 鑑別除BMS3h-129及BMS3h-197外之所有譜系的解離速 率改良之純系。如上所述，在基於珠粒或基於ELISA之受 體結合分析（RBA)中測試解離速率改良之純系以對效能之 改良進行評估。在標註為「易錯成熟之純系」的表中給出 由RB A獲得之效能量測結果。隨後在B細胞增殖分析中測 試在RB A中更有效之純系以評估生物效能之提高，且表1 7 中給出所獲得之此等量測結果。亦在多種其他活體外細胞 分析中測試在B細胞增殖分析中效能改良之域抗體。 藉由三聯體掃描多樣化進行親和力成熟 選擇自易錯成熟分離的5種效能改良之dAb，亦即 BMS3h-37-2、BMS3h-38-2、BMS3h-56-2、BMS3h-193-25 及BMS3h-217-23，以藉由三重掃描多樣化進一步親和力成 熟。基於如上針對易錯文庫所述之此等親本構築噬菌體文 庫，其中例外為替代使用易錯PCR，使用一系列重疊簡併 三聯寡核苷酸來多樣化各dAb之互補決定（CDR)區。對於 待親和力成熟之各dAb，使用含有NNS密碼子三聯體之寡 核苦酸（參見 Arkin 等人（1992) iVoc. Jcac/· 5cz·. £75^4 89:7811-7815)藉由重疊延伸拼接（slicing by overlap extension，SOE) PCR製得各CDR之許多文庫。利用寡核苷 酸針對兩個密碼子重疊之既定CDR使三聯體多樣化，每個 CDR產生2至4個文庫。BMS3h-37-2文庫中多樣化之胺基酸 163920.doc -185- 201245225 殘基在位置 30、31、32、33、35、50、52、53、55、56、 95、96、97及 98 (Kabat編號）。BMS3h-38-2文庫中多樣化 之殘基如同BMS3h-3 7-2—般，但添加了位置100。BMS3h-56-2文庫中多樣化之殘基如同BMS3h-37-2—般，但添加了 位置 100 及 101。BMS3h-193-25 及 BMS3h-217-23 文庫中多 樣化之殘基在位置27、28、30、31、32、34、49、50、 51、53、89、91、92 ' 93、94及96 〇 由此等文庫產生之噬菌體藉由CDR混合且如上所述執行 選擇，其中例外為對於BMS3h-37-2、BMS3h-38-2、 BMS3h-56-2及BMS3h-193-25，第1輪、第2輪及第3輪所用 抗原之濃度分別為10 nM、1 nM及0.1 nM。對於BMS3h· 217-23，第1輪、第2輪及第3輪之所用抗原之濃度分別為 20 nM、2 nM及0.2 nM。對於對獼猴CD40具交叉反應性之 BMS3h-193-25 ’亦並行地針對獼猴CD40執行選擇。另 外，分別在存在或不存在1〇〇倍或1〇00倍過量之未標記 CD40之情況下執行第2輪及第3輪選擇。在最初使噬菌體 與生物素標記抗原一起培育1小時之後添加此競爭劑，且 接著如前所述再培育混合物1小時。包括此競爭步驟，目 的在於增強對具有較慢解離速率之dAb之選擇。第1輪效價 在1.4X106至1.4xl〇9之範圍内。在無競爭之情況下第2輪之 效價為1.3M05至4·〇χ1〇8，且在有競爭之情況下為8 6χι〇4 至1.3X108。在無競爭之情況下第3輪中之效價為i 2χΐ〇5至 1.9χ108，且在有競爭之情況下為6 〇><1〇5至丨2χ1〇8。 如關於易錯親和力成熟所述次選殖且篩檢此等選擇輪 163920.doc -186· 201245225 出。鑑別除BMS3h-193-25外之所有譜系的解離速率改良之 純系。在ELISA受體結合分析（RBA)中測試解離速率改良 之純系以對效能改良進行評估。在標註為「進一步成熟之 純系」的表中給出由RBA獲得之效能量測結果。隨後在B 細胞增殖分析中測試在RB A中更有效之純系以評估生物效 能之提高，且表1 7中給出所獲得之此等量測結果。亦在多 種其他活體外細胞分析中測試在B細胞增殖分析中效能改 良之域抗體。 φ 實例2 使用受體結合分析（RBA)進行篩檢 使用若干活體外受體結合分析（RBA)測定實例1中產生之 抗人類CD40可變域胺基酸序列之CD40親和力。使用三種 RBA格式：（1)珠粒 RBA、（2) ELISA RBA及（3) CHO 細胞 RBA。 經磷酸鹽緩衝鹽水（PBS)洗滌之Sphero抗生蛋白鏈菌素 9 聚苯乙稀粒子（Saxon Europe，UK)用0.5 pg/ml生物素標記 人類IZ-CD40L (BMS)塗佈。塗佈之後，用PBS洗滌生物素 標記CD40L粒子且用含0.1% (w/v)胎牛血清白蛋白（BSA) (Sigma-Aldrich，UK)之PBS分析緩衝液以1:10稀釋。在384 孔透明底黑色壁培養盤（Applied Biosystems)中，等量組合 稀釋範圍之純化（lAb、0.25 pg/ml人類CD40 (BMS， CY24FEB06-01)、1/ί;000小鼠抗人類 IgG (Fc) mAb純系00·
7 (Sigma-Aldrich，UK)、0·25 pg/ml 山羊抗小鼠 ALEXA 163920.doc -187- 201245225
Fluor 647 (Invitrogen，Molecular probes，UK)及生物素標記 CD40L聚苯乙烯粒子且在無光存在下在室溫下培育6小 時。培育之後，使用相對螢光用AB8200細胞偵測機制 (Applied Biosystems)評估dAb相對於人類CD40與生物素標 記CD40L粒子之競爭性結合。 ELISA RBA ·· 在4°C下用25 μΐ 1 pg/ml中性鏈親和素於0.2 Μ碳酸鹽碳 酸氫鹽緩衝液（pH 9.4)中之混合物塗佈透明壁高結合384孔 培養盤（Corning，UK)隔夜。第二天，用0.1% (v/v)吐溫PBS · 緩衝液洗滌分析培養盤，在室溫下用含1% (w/v) BSA之 PBS阻斷1小時且再次洗滌。在移除過量洗滌緩衝液之後， 在室溫下使25 μΐ 1 pg/ml生物素標記人類IZ-CD40L(BMS) 與該等分析培養盤一起培育1小時。同時，稀釋範圍之純 化 dAb 與 1 pg/ml 人類 CD40 (BMS，CY24FEB06-01)以 1:1 之 比率複合。在洗滌分析培養盤之後，在室溫下，在輕微攪 動下，在分析培養盤中培育dAb:人類CD40複合物2小時。 在 1/5000 小鼠抗人類 IgG (Fc) mAb 純系 GG-7 (Sigma- φ Aldrich，UK)，隨後 1/10,000 辣根過氧化物酶（horse radish peroxidase，HRP)結合之山羊抗小鼠IgG (Fc)第二偵測抗 體（Sigma-Aldrich, UK)相繼培育下，偵測dAb相對於人類 CD40與生物素標記CD40L之競爭性結合。在用1M HC1溶 液中和之後，使用SpectraMax M5e培養盤讀取器 (Molecular Devices)在450 nm下量測吸光度信號。 細胞分析·· CO4Q CHO細胞RBA : 163920.doc •188· 201245225 使用凡爾生（Invitrogen)自細胞培養燒瓶分離穩定轉染之 表現人類CD40之CHO-DG44細胞或天然CHO-DG44細胞（皆 為BMS)。將每孔4萬個細胞於具有稀釋範圍之dAb、0.25 pg/ml生物素標記人類IZ-CD40L (BMS)及0.25 pg/ml抗生蛋 白鍵菌素 Alexa Fluor 647 (Invitrogen，Molecular probes, UK)之0.1% (w/v) Bi;A PBS分析緩衝液中接種至96孔高結 合黑色壁透明底培養盤（Corning, UK)中。在無光存在下培 育混合物6小時。培育之後，使用相對螢光用AB8200細胞 福測機制（Applied Eiosystems)評估dAb相對於人類CD40 CHO細胞與可溶性生物素標記IZ-CD40L之競爭性結合。 表5至表7分別顯示測試之抗人類CD40 dAb之初步篩檢 工作（「未處理純系」）及後續各輪親和力成熟（「易錯成熟 之純系」及「進一步成熟之純系」）的結果。 表5 初步篩檢工作：
未處理純系 珠粒RBA之 EC50 (nM) ELISA RBA 之 ECs〇 (nM) 細胞 RBA(CHO-CD40) 之 ECs〇 (nM) BMS3h-37 100、200 BMS3h-38 600、650 >i〇〇〇〇 BMS3h-41 2000、1600 >i〇〇〇〇 BMS3h-43 100、50、5(1 5000 BMS3h-56 1000 ' 500 BMS3h-106 300、1000、500、400 >10000 BMS3h-129 5000 BMS3h-131 500、>1000 BMS3h-193 1000 BMS3h-197 30 BMS3h-198 80 600 BMS3h-202 3000、3700 >10000 BMS3h-217 800 1400 BMS3h-231 670、870 163920.doc -189- 201245225 未處理純系 珠粒RBA之 EC5〇(nM) ELISA RBA之 ECs〇 (nM) 細胞 RBA(CHO-CD40) 之 ECS0 (nM) BMS3h-233 2770 BMS3h-257 3210、1340 BMS3h-242 390、210 BMS3h-262 1770、1160 BMS3h-263 3130 BMS3h-271 370、210 BMS3h-285 168'258 BMS3h-287 >10000'6758 BMS3h-289 2390 ' >10000 表6易錯成熟之純系： 純系 ELISA RBA^lECso (nM) 細胞 RBA (CHO-CD40)之 EC5〇 (uM) BMS3h-37-2 32 BMS3h-37-4 45 BMS3h-37-ll 27 BMS3h-38-5 1000 BMS3h-38-8 2800 BMS3h-41-3 200 BMS3h-41-10 4300 BMS3h-43-3 320 BMS3h-43-5 90 BMS3h-56-l 7.1 BMS3h-56-2 17.0 BMS3h-56-5 4.9、7.5、4.7 18、28 BMS3h-56-7 5.5 BMS3h-56-8 6.2 BMS3h-56-9 4.4 、 5.5 BMS3h-56-16 7.0 BMS3h-56-17 66 BMS3h-56-18 6.5 BMS3h-56-19 5.5 、 5.1 BMS3h-56-20 6.8 BMS3h-56-21 6.5 ' 6.2 BMS3h-56-22 6.5 BMS3h-56-23 24.5 BMS3h-56-24 11.7 BMS3h-56-25 5.5 BMS3h-56-26 5.0 BMS3h-56-27 16.3 BMS3h-56-28 8.9 BMS3h-56-29 9.7 BMS3h-56-30 24.2 163920.doc -190- 201245225
純系 ELISA RBA之ECS0 (nM) 細胞RBA (CHO-CD40)之ECS0 (nM) BMS3h-56-31 61.0 BMS3h-193-5 >300 BMS3h-193-7 300 BMS3h-193-10 200 BMS3h-l 93-11 300 BMS3h-193-12 200 BMS3h-193-15 300 BMS3h-193-18 100 BMS3h-193-19 100 BMS3h-193-25 140 BMS3h-193-26 100 BMS3h-193-27 100 BMS3h-193-29 360、114 BMS3h-193-30 290 > 116 BMS3h-198-l 12 70 BMS3h-198-2 115 BMS3h-198-3 330 BMS3h-198-9 20 BMS3h-198-10 35 BMS3h-198-ll 20 BMS3h-198-14 9 BMS3h-198-17 20 BMS3h-198-19 7.9 BMS3h-198-22 10 BMS3h-l 98-31 6.1 BMS3h-198-32 24.7 BMS3h-198-33 8.7 BMS3h-198-34 32.6 BMS3h-198-37 15.1 BMS3h-198-38 7.2 BMS3h-202-10 7200 BMS3h-202-ll 8300 BMS3h-217-l 23 BMS3h-217-2 78 BMS3h-217-3 32 BMS3h-217-4 部分、15 BMS3h-217-5 65 BMS3h-217-6 26 BMS3h-217-7 39 BMS3h-217-8 6 BMS3h-217-9 53 BMS3h-217-14 8 BMS3h-217-15 21 BMS3h-217-16 9 BMS3h-217-17 60 BMS3h-217-23 16 163920.doc -191 - 201245225 表7 進一步成熟之純系： 純系 ELISARBA 之 ECs〇 (nM) ICAM1細胞分 析之 EC50 (nM) 細胞 RBA(CHO-CD40)之 ECS0 (nM) BMS3h-37-202 4.1 ' 35 BMS3h-37-205 3.1 ' 4.4 BMS3h-37-206 3.2 ' 8.9 BMS3h-37-207 2.5 > 6.6 BMS3h-37-212 24 BMS3h-37-213 16 BMS3h-38-201 3.4、非活性 BMS3h-3 8-202 4.8 BMS3h-38-203 5.5 BMS3h-38-204 4.8 BMS3h-38-205 4.5、11.1 BMS3h-38-209 10.2 BMS3h-38-211 2.3 > 13.8 BMS3h-38-215 2.3 ' 3.6 BMS3h-38-217 1.8 、 2.2 BMS3h-38-218 3.0 BMS3h-38-219 1.8 > 7.1 BMS3h-38-223 5.7 BMS3h-3 8-224 6.3 BMS3h-3 8-225 8.8 BMS3h-3 8-226 18.1 BMS3h-38-228 4 BMS3h-3 8-231 4.4 BMS3h-38-235 1.5 BMS3h-38-237 2 BMS3h-38-238 5.1 BMS3h-56-201 3.7 > 2.3 10.0 BMS3h-56-202 3.4 ' 3.2 80.0 BMS3h-56-203 5.2'4.3 70.0 BMS3h-56-204 4.5 BMS3h-56-205 9.0 BMS3h-56-206 2.9 ' 2.3 5.0 BMS3h-56-207 7.3 BMS3h-56-215 3.2'4.6 40.0 BMS3h-56-217 2.1 > 12.6 BMS3h-56-220 4.2 BMS3h-56-223 5.0 BMS3h-56-224 2.1 ' 4.2 BMS3h-56-225 2.9 BMS3h-56-229 4.1
163920.doc •192· 201245225 純系 ELISARBA 之 ECs〇 (nM) ICAM1細胞分 析之EC5〇 (nM) 細胞 RBA(CHO-CD40)之 ECS0 (nM) BMS3h-56-232 2.8 ' 3.7 BMS3h-56-239 2.7 BMS3h-56-243 9.9 BMS3h-56-244 6.0 BMS3h-56-246 11.1 BMS3h-56-248 0.7 BMS3h-56-253 1.3 BMS3h-56-258 ：5.2 23.0 15 BMS3h-56-261 ：>.7 42.4 17 BMS3h-56-262 4.0 135.0 42 BMS3h-56-265 18.8 289.0 88 BMS3h-56-266 ：l.8 31.9 27 BMS3h-56-269 3.3 34.2 24 BMS3h-56-270 11.3 93.8 91 BMS3h-193-2501 114 BMS3h-193-2502 170 BMS3h-193-2503 3000 BMS3h-193-2504 140 BMS3h-l 93-2505 fOO BMS3h-193-2506 180 BMS3h-193-2507 160 BMS3h-193-2510 170 BMS3h-l 93-2511 270 BMS3h-193-2512 ¢:00 BMS3h-193-2513 130 BMS3h-193-2514 525 BMS3h-193-2515 100 BMS3h-193-2516 100
實例3 CD40結合動力學 測定初步篩檢工作（「未處理純系」）及後續各輪親和力 成熟（「易錯成熟之純系」）中所鑑別之抗人類CD40 dAb的 結合動力學。所用之方法直接量測dAb對CD40之親和力》 使用 BIAcoreTM 3000儀器（GE Healthcare)分析 CD40特異 性dAb與CD40之結合動力學。將約600個反應單位（RU)之 生物素標記人類CD40 (BMS)固定於抗生蛋白鏈菌素（S A) BIAcoreTM晶片之一個流槽上。將未固定有任何配位體之 163920.doc •193· 201245225 第二流槽用作參比流槽進行線内參比。用HBS-ΕΡ緩衝液 (具有 0.15 M NaCl、3 mM EDTA及 0.005% v/v界面活性劑 P20 之 0.01 M HEPES (pH 7.4)，GE Healthcare)製備一系歹-J 適當二倍稀釋之各待分析之dAb。使用儀器之KINJECT功 能一式兩份注射180 μΐ各dAb。將各dAb注射於串聯之固定 CD40之流槽及參比流槽上，線内減去來自參比槽之信 號。在25艽及30 μΐ/min之HBS-ΕΡ流速下執行實驗。在各 注射完成後’允許在緩衝液中自配位體解離dAb 300秒， 隨後由注射10 μΐ 10 mM甘胺酸（pH 2.0)而再生。亦在相同 條件下注射HBS-ΕΡ緩衝液空白參比注射劑（不包含分析 物），以用作自各分析物跡線減去之第二參比。使用 BIAevaluation 4·1軟體（GE Healthcare)自各分析物跡線減 去參比流槽跡線與緩衝液空白跡線。使用同一軟體同時整 體擬合分析物稀釋液系列跡線之締合及解離階段的1:1 (朗 繆爾）動力學模型。此模型產生相互作用之締合及解離速 率常數（分別為幻及h)及平衡解離常數（i：D);此等常數詳示 於表8及表9中。 表8 未處理純系： 純系 BlAcoreiM MmV1) BIAcore,M BIAcore"*1 ΛΓ〇(Μ) BMS3h-37 1.9E+04 3.6E-03 1.9E-07 BMS3h-38 2.1E+04 6.2E-03 3.0E-07 BMS3h-41 9.9E+03 8.3E-03 8.4E-07 BMS3h-43 1.4E+03 3.1E-03 2.1E-06 BMS3h-56 2.3E+04 4.0E-03 1.8E-07 BMS3h-106 1.3E+05 4.6E-02 3.5E-07 BMS3h-107 2.0E+05 1.7E-01 8.5E-07 163920.doc •194· 201245225 純系 BIAcore™ (mV) BIAcore™ ^(s1) BIAcore1M JS：d(M) BMS3h-129 4.7E+05 5.1E-01 1.1E-06 BMS3h-131 2.4E+04 2.2E-02 9.3E-07 BMS3h-197 8.1E+04 1.4E-02 1.8E-07 BMS3h-198 1.6E+03 3.8E-04 2.4E-07 BMS3h-202 1.7E+03 3.5E-03 2.0E-06 表9 易錯成熟之純系. 純系 BIAcore™ /fa (MV1) BIAcore1 M k& (s1) BIAcore™ Kn(M) BMS3h-37-2 1.0E+05 4.1E-04 4.0E-09 BMS3h-37-5 3.9E+04 2.2E-04 5.5E-09 BMS3h-37-9 1.5E+04 1.8E-04 1.2E-08 BMS3h-38-l 3.2E+04 1.1E-03 3.3E-08 BMS3h-38-2 6.1E+04 7.5E-04 1.2E-08 BMS3h-38-3 7.5E+04 4.1E-04 5.5E-09 BMS3h-41-l 5.1E+04 5.6E-04 1.1E-08 BMS3h-43-l · 4.4E+03 6.3E-04 1.4E-07 BMS3h-43-3 3.1E+04 5.9E-04 1.9E-08 BMS3h-56-l 9.8E+04 5.4E-04 5.5E-09 BMS3h-56-2 1.1E+05 6.0E-04 5.3E-09 BMS3h-56-5 1.1E+05 6.3E-04 5.9E-09 BMS3h-56-7 1.3E+05 4.7E-04 3.5E-09 BMS3h-56-9 1.5E+05 3.9E-04 2.6E-09 BMS3h-131-2 7.9E+04 1.7E-03 2.1E-08 BMS3h-193-25 4.6E+05 3.7E-02 8.1E-08 BMS3h-198-1 1.5E+04 1.8E-04 1.3E-08 BMS3h-202-5 4.4E+03 1.3E-03 3.0E-07 實例4 生物物理表徵 藉由生物物理參數之分析進一步表徵初步篩檢工作 (「未處理純系」）及後續各輪親和力成熟（「易錯成熟之純 系」及「進一步成熟之純系」）中所鑑別之抗人類CD40 dAb。為了量測dAb之相對穩定性，藉由差示掃描熱量測 定法（differential scanning calorimetry，DSC)測定其溶 點。具有較高熔融溫度之dAb更穩定。為了測定dAb是否 163920.doc •195- 201245225 在溶液中形成多聚聚集體，藉由尺寸排阻層析法/多角雷 射光散射（size exclusion chromatography/multiangle laser light scattering，SEC-MALLS)分析dAb。結果示於表 10至 表12中。 表10 未處理純系： 純系 DSC (Tm/°C) SEOMALS溶液狀態 BMS3h-38 59 單體及二聚體(<5%) BMS3h-41 59 單體及單體-二聚體平衡(<5°/〇) BMS3h-43 二聚體及三聚體 BMS3h-56 57 單體及二聚體(<1〇%) BMS3h-106 單體 BMS3h-107 63 單鱧 BMS3h-129 59 單體 BMS3h-193 56 單體 BMS3h-197 62&53 單逋及二聚體(<5%) BMS3h-198 61 單體 BMS3h-202 60 單體及單體-二聚體平衡(<2%) BMS3h-207 二聚體及四聚體 BMS3h-208 單體及二聚體 BMS3h-217 57 二聚體 BMS3h-233 單體 BMS3h-242 單體及單體-二聚體 BMS3h-262 單體 BMS3h-265 二聚體 BMS3h-271 二聚體 BMS3h-285 單體
表11 易錯成熟之純系. 純系 DSC Tm/°C SEC-MALS溶液狀態 BMS3h-37-l 57.2 BMS3h-37-2 56.2 BMS3h-37-9 59.7 163920.doc -196- 201245225
純系 DSC Tm/°C SEC-MALS溶液狀態 BMS3h-37-ll 60.0 BMS3h-56-l 49.6 單體 BMS3h-56-2 63.0 單體及二聚體(<2°/〇) BMS3h-56-3 64.0 單體(>98%) BMS3h-56-5 51.2 BMS3h-41-l 56 單體(約99%) BMS3h-41-2 53.4 · BMS3h-41-3 51.8 BMS3h-41-9 61 單體及單體/二聚體快速平衡(<2%) BMS3h-41-12 49.8 單二聚體 BMS3h-41-13 單趙/二聚體 BMS3h-43-l 53 單體(約99%) BMS3h-43-3 51.2 BMS3h-43-5 48.2 單體/二聚體 BMS3h-43-10 51.8 BMS3h-43-ll 54.8 BMS3h-43-12 二聚體(60%)及單體(40%) BMS3h-56-l 59.2 單體/二聚體 BMS3h-56-2 60.1 單體/二聚體 BMS3h-56-5 57 單體(>95%) BMS3h-56-6 57.5 單體/二聚體 BMS3h-56-7 61 單體+單體/二聚體快速平衡(<5%) BMS3h-56-8 58 單體(>98%) BMS3h-56-9 61 單體+二聚體(<5%) BMS3h-56-14 60.1 單體 BMS3h-193-8 60 BMS3h-193-12 52 BMS3h-193-16 54.5 S: 65.7 單體 BMS3h-193-19 56.8 單體 BMS3h-193-25 55.8 單體 BMS3h-193-29 60 單體 BMS3h-193-30 58 BMS3h-198-l 52.5 單體 BMS3h-198-2 單體 BMS3h-198-3 59 BMS3h-198-5 55.6 BMS3h-198-19 60.7 BMS3h-198-24 59.9 單體 BMS3h-198-28 60.3 單體 BMS3h-202-l 56.8 單體 BMS3h-202-5 55.5 三聚體(60%)及單體/二聚體(40%) BMS3h-202-10 58.3 三聚體(60%)及單體/二聚體(40%) 163920.doc •197· 201245225 純系 DSC Tm/°C SEC-MALS溶液狀態 BMS3h-217-l 單體/二聚體 BMS3h-217-2 二聚體 BMS3h-217-3 二聚體 BMS3h-217-4 單體/二聚體 BMS3h-217-5 二聚體 BMS3h-217-6 二聚體 BMS3h-217-8 二聚體 BMS3h-217-14 單體/二聚體 BMS3h-217-15 二聚體 BMS3h-217-16 二聚體 BMS3h-217-17 單體/二聚體 BMS3h-217-23 二聚體 表12
進一步成熟之純系：
純系 DSC Tm/°C SEC-MALS溶解狀態 BMS3h-3 7-206 單體(73%)及二聚體(20%)+HMW BMS3h-37-212 二聚體 BMS3h-38-201 單體(75%)及二聚體(15%) BMS3h-3 8-228 單體(90%)及三聚體(10%) BMS3h-38-231 單體(90%)及二聚體(10%) BMS3h-38-235 單體(90%)及三聚體-二聚體 BMS3h-38-237 單體(90%)及四聚體(10%) BMS3h-38-238 單體(95%)及二聚體-單體 BMS3h-56-201 57.4+61.8 單體及二聚體(15%) BMS3h-56-202 單體 BMS3h-56-203 單體及三聚體 BMS3h-56-206 單體 BMS3h-56-215 單體、二聚體(2%)及三聚體(9%) BMS3h-56-217 52.8+54.6 BMS3h-56-232 51.0+56.1 單體(95%)及二聚體(5%) BMS3h-56-239 53.5 單體 BMS3h-56-243 51.9 單體及五聚體 BMS3h-56-244 單體(90%)及三聚體(10%) BMS3h-56-248 單體(60%)、二聚體及四聚體 BMS3h-56-253 單體 BMS3h-56-258 62.5+57.5 BMS3h-56-261 58.6+61.5 BMS3h-56-266 61.3+62.3 BMS3h-56-269 64.5+67.2 163920.doc -198- 201245225 實例5 競爭分析 使用 BIAcoreTM 3000儀器（GE Healthcare)分析 CD40特異 性dAb是否結合相同CD40抗原決定基。將約600個反應單 位（RU)之生物素標記人類CD40 (BMS)固定於抗生蛋白鏈 菌素（SA) BIAcoreTM晶片之一個流槽上。將未固定有任何 配位體之第二流槽用作參比流槽進行線内參比。用HBS-ΕΡ 緩衝液（具有 0.15 M Naa、3 mM EDTA 及 0.005% Wv 界 面活性劑P20 之 0.01 M HEPES (pH 7.4)，GE Healthcare)製 備適當稀釋之各待分析之dAb或Fab»所選稀釋液為在如下 文所述注射時對於特定抑制劑（典型地為1 μΜ至10 μΜ)產 生>80%之最大可能結合RU的稀釋液。接著，製備與上文 (在相同最終濃度下）相同之dAb或Fab與待進行競爭分析之 第二dAb或Fab的混合物。使用儀器之COINJECT功能將60 μΐ單一抑制劑稀釋液注射於串聯之固定CD40之流槽及參比 流槽上，隨後立即注射60 μΐ兩抑制劑混合物。藉由儀器之 控制軟體線内減去來自參比槽之信號。在25°C及30 μΐ/min 之HB S-EP流速下執行實驗。各次共注射完成後，允許在 緩衝液中自配位體解離抑制劑60秒，隨後由注射1〇 μΐ 1〇 mM甘胺酸（pH 2.0)而再生。記下獲得之第二庄射劑（兩抑 制劑之混合物）之最大RU且表示為單獨注射時獲得之相同 抑制劑的RU之百分比。 若第二抑制劑保留在單獨注射其時通常結合之RU的至 少100%，則此表示兩種抑制劑結合至個別抗原決定基。 163920.doc -199- 201245225 若觀測到第二抑制劑之結合小於100%，則此指示兩種抑 制劑之間結合至CD40的競爭。此競爭存在若干可能原 因：兩種抑制劑可結合至同一或重疊抗原決定基，可能存 在結合之空間抑制，或第一抑制劑之結合可能誘發能阻止 或減少第二抑制劑結合之抗原構形變化。 測試來自各譜系之實例純系（BMS3h-217除外）與重疊群 組中之其他dAb之競爭。如表13及表14中所示，所有所測 試之dAb似乎會彼此競爭結合於CD40。此資料表明所有選 自由譜系61^8311-37、8]^3311-38、81^8311-41、8]\^311-43、BMS3h-56、BMS3h-131、BMS3h-198 及 BMS3h-202 組 成之群的抗體多肽應與來自任一此等譜系之dAb與人類 CD40的結合競爭。 表13 競爭 BIAcoreTM : 第一注 射劑 第一單獨 dAb 之 RU 第二注射劑(單一dAb RU之百分比） BMS3h- 56-5 BMS3h- 37-11 BMS3h- 131-2 BMS3h- 198-1 BMS3h- 202-11 BMS3h- 56-5 245 . ' i ~ -15 17 0.6 7.3 BMS3h- 37-11 158 15 . . 25 16 0.3 BMS3h- 131-2 220 22 -3.7 23.2 10.3 BMS3h- 198-1 176 28 6.4 41 18 BMS3h- 202-11 124 50 42 57 39 163920.doc •200· 201245225 表14 第一注射劑 第一單獨 dAb 之 RU 第二注射劑(單一dAb RU之百分比） BMS3h-38-2 BMS3h-41-9 BMS3h-43-l BMS3h-56-5 BMS3h-38-2 170 11 29 29 BMS3h-41-9 150 27 * > \ ^ xr ' ^ ^ ,- 44 47 BMS3h-43-l 210 20 19 • ·;< ^ - 39 BMS3h-56-5 190 4 0 22
類似地，如表15及表16中所示，測試各種dAb與Chi220 Fab·之競爭。在此情況下，所有dAb不與Chi220 Fab，競 爭，其中例外為BMS3h-217，其顯示競爭。在結合之 Chi220 或 G28-5 Fab’存在下，BMS3h-56-5 及 BMS3h-193-12 dAb以至少100%之單一 dAb RU結合，從而表明Fab·結合與 dAb不同之抗原決定基^ Chi220 Fab·顯示在G28-5存在下結 合RU降低。在相反次序之結合中觀測到相同之結果。此 表明G28-5 Fab，結合與Chi220 Fab·相同之抗原決定基。 表15 第一注射劑 第一單獨 dAb/Fab 之RU 第二注射劑(單一dAb/Fab RU之百分比） BMS3h- .56-5 Chi220 Fab G28-5 Fab BMS3h- 193-12 BMS3h-56-5 193 98 94 64 Chi220 Fab 1089 105 11 109 G28-5 Fab 730 125 39 116 BMS3h-193-J2 282 44 98 93 表16 純系名稱 所測試dAb或Fab之μΜ 單一 dAb之 RU 單一dAb RU之百分比 (Chi220+dAb) BMS3h-38-2 5 156 121 BMS3h-41-13 5 162 109 BMS3h-43-3 5 300 101 BMS3h-38-2 5 175 114 BMS3h-56-5 5 193 105 163920.doc •201 · 201245225 BMS3h-106 10 165 111 BMS3h-107 10 35 146 BMS3h-129 10 156 121 BMS3h-193-12 5 282 98 BMS3h-197 1 177 116 BMS3h-217 10 85 25 G28-5 Fab 1 730 11 實例6 CD40活性分析 功能上分析抗人類CD40 dAb拮抗CD40活性之能力°所 測試之CD40活性為藉由hCD40L驅動之初級人類單核細胞 衍生之樹突狀細胞（dendritic cells，DC)活化進行之B細胞 增殖及細胞激素產生。除非另外說明’否則所有分析均在 補充有10%胎牛血清（fetal calf serum ’ FCS)之RPMI培養基 中執行。使用各種分析得到之結果示於表17中。 可溶性lZ-hCO4QL驅動之初級人類B細胞增殖： 在96孔圓底培養盤中以每孔200 μΐ之最終體積用0.6 pg/ml IZ-hCD40L以及不同滴定量之抗體多肽培育1χ1〇5個 扁桃體人類Β細胞。在37°C下培育培養盤72小時，接著添 加胸腺嘧啶核苷（3H ; 0.5 μ<ή/孔）6小時。基於胸腺嘧啶核 苷併入法定量Β細胞增殖。 CHO-hCD40L驅動之初級人類Β細胞增殖： 用人類CD40L轉染CHO細胞以產生以較高CD40L表現程 度表現於細胞表面上之穩定細胞株。以1 〇,〇〇〇拉德（Rad)照 射CHO-CD40L細胞，隨後用人類B細胞培育。在96孔圓底 培養盤中以每孔200 μΐ之最終體積用lxlO3個CHO-CD40L 細胞（CHO-CD40L:人類B細胞之比率為1:1〇〇)以及不同滴 I63920.doc -202- 201245225 定量之抗體多肽培育1χ 105個扁桃體人類B細胞《在37eC下 培育培養盤72小時，隨後添加3H_胸腺嘧啶核苷（〇 5卩以/ 孔）ό小時》基於胸腺响咬核苷併入法定量β細胞增殖。 可溶性ΙΖ-hCmOL驅動之獼猴脾人類乜細胞增殖： 在96孔圓底培養盤中以每孔200 μΐ之最終體積用0.5 pg/ml IZ-hCD40L以及不同滴定量之抗體多肽培育ιχ1〇5個 摘猴脾Β細胞。在37°C下培育培養盤72小時，隨後添加3Η-胸腺嘧啶核苷（0.5 μ<:;ί/孔）6小時。基於胸腺嘧啶核苷併入 法定量Β細胞增殖。 初級τ細胞驅動之人類β細胞增殖： 自人類周邊血液單核細胞（peripheral blood mononuclear cells ’ PBMC)分離T細胞且使用绵羊紅血球（sheep red blood cell ’ SRBC)花結法富集。藉由將扁桃體組織均質化 於單細胞懸浮液中分離人類扁桃體B細胞。藉由菲科爾分 離（Hcoll separation)獲得白血球，接著使用SRBC花結法被 動選擇B細胞且藉由去除花結細胞來富集。 在37C下用PM-LCL (EBV轉化B細胞株；以1〇,〇〇〇拉德 照射）以5:1之比率（t:LCL)培養富集人類T細胞6天以產生同 種異體T細胞群。在第6天，分離擴增之τ細胞且以3〇〇〇拉 德照射’且接著在塗有抗CD3 mAb (OKT3)之96孔平底培 養盤中，用初級人類扁桃體B細胞（每孔1χι〇5個β細胞）以 1:2之比率培養（每孔5χ104個T細胞）。將不同滴定量之抗體 多肽添加至各孔中；各孔之最終體積為2〇〇 μ1。在37〇c下 培育測試培養盤3天。在最後18小時内經由添加3η·胸腺嘧 163920.doc •203 · 201245225 。定核苷（0·5 μίή/孔）至培養物中測定人類B細胞增殖。 CHO-hCD40L驅動之初級人類單核細胞衍生之樹突狀細胞 (DC)活化‘· 藉由經由SRBC花結法去除T細胞來使人類PBMC富集單 核細胞。在37°C ’下在6孔培養盤中用1〇 ng/ml GM-CSF及 5 ng/ml IL-4培養富集單核細胞之PBMC 6天。在第2天及第 5天用新鮮培養基（具有GM-CSF及IL-4)補充所培養之培養 盤。在細胞分析中在第6天使用未成熟樹突狀細胞（DC)。 在96孔平底培養盤中，用4χ103個CHO-hCD40L細胞（以 10,000拉德照射）以及不同滴定量之抗體多肽培養8xl04個 未成熟DC。24小時後，收集上清液且測試各種細胞激素 (IL-12、TNF、IL-23)之存在。DC活化藉由細胞激素之產 生量來測定。 表17 純系 hIZCD40L 驅 動之人類B 細胞增殖 EC5〇 (nM) WZCD40L 驅 動之獼猴B 細胞增殖 ECso (nM) CHO-hCD40L 驅 動之人類B 細胞增殖 ECs〇 (nM) T-B細胞 MLR ECs〇 (nM) CHO-hCD40L 驅 動之DC活化 IL-12 EC50 (nM) 3h-5 >7000 >7000 3h-8 >7000 >7000 3h-28 >7000 >7000 3h-33 >7000 >7000 3h-48 >7000 >7000 3h-52 >7000 >7000 3h-57 >7000 >7000 3h-61 >7000 >7000 3h-88 >7000 3h-102 >7000 3h-106 437.0 士 214.0 >7000 3h-107 >7000 >7000 3h-112 >7000 163920.doc -204- 201245225
純系 MZCD40L 驅 動之人類B 細胞增殖 ECs〇 (nM) hIZCD40L 驅 動之獼猴B 細胞增殖 EC：s〇 (nM) CHO-hCD40L 驅 動之人類B 細胞增殖 EC5〇 (nM) T-B細胞 MLR EC5〇 (nM) CHO-hCD40L 驅 動之DC活化 IL-12 EC5〇 (nM) 3h-129 2100.0 士 1000.0 3h-197 360.0 ± 500.0 >7000 3h-207 >7000 3h-208 >7000 3h-37 3400.0 ± 2900.0 >7000 3h-37-l 250.0 土 100.0 3h-37-2 5.0 ±2.0 >7000 198 ±35 13.0 ±7.3 3h-37-202 0.6 ± 0.2 83± 18 10.0 3h-37-205 2.0 ± 1.0 6.6 3h-37-206 5.0 ±0.8 23.0 3h-37-207 4.0 ±2.0 15.5 ±8.0 3h-37-212 1.0 ±0.05 3h-37-213 0.7 ±0.2 3h-37-ll 8.0 ±7.0 3h-38 2800.0 ± 400.0 >7000 3h-38-l 142.0 ±86.0 3h-38-2 10.0 ±6.0 >7000 723.0 ± 185.0 986 ±383 289.0 土 315.0 3h-38-201 >70.0 >7000 >800.0 3h-3 8-205 4.0 ±2.0 1100.0 士 141.0 29.0 3h-38-211 2.0 ± 1.0 82.0 ±4.0 200 ± 1 18.0 ±19.0 3h-38-215 1.0 ±0.0 65.0 ± 1.0 163 ± 14 6.0 ±4.0 3h-38-217 0.8 ±0.2 34.0 ±6.0 74 ±22 1.7 ±0.4 3h-38-219 2·0±0.5 93.0 ±26.0 164 ±3 9.0 ±5.0 3h-3 8-228 0.7 ± 0.05 3h-3 8-231 0.66 士 0.2 3h-38-235 0.4 ± 0.2 3h-38-237 0.4 ± 0.2 3h-38-238 0.7 ± 0.03 3h-38-3 10.0 ±7.0 3h-41 >7000 3h-41-l 104.0 ±56.0 3h-41-2 47.0 ± 67.0 3h-41-3 12.0 ±7.0 >7000 3h-41-9 148.0 ±98.0 3h-41-12 104.0 ± 50.0 3h-41-13 208.0 ±90.0 163920.doc -205- 201245225 純系 MZCD40L 驅 動之人類B 細胞增殖 EC50 (nM) WZCD40L 驅 動之獼猴Β 細胞增殖 EC5〇 (nM) CHO-hCD40L 驅 動之人類Β 細胞增殖 EC50 (nM) T-B細胞 MLR ECs〇 (nM) CHO-hCD40L 驅 動之DC活化 IL-12ECs〇 (nM) 3h-43 83.0 ±40.0 >7000 3h-43-l 53.0 ±20.0 3h-43-3 87.0 ± 19.0 3h-43-5 180.0 士 130.0 3h-43-10 143·0 士 131.0 3h-43-ll 30.0 ± 19.0 3h-43-12 12.0 ±6.0 3h-56 713.0士 133.0 >7000 3h-56-l 7.0 ±5.0 3h-56-2 3.0 ± 1.0 326.0 ± 79.0 276 ± 29 444.0， >2000.0 3h-56-201 0·12±0·04 11.0 ±6.0 7.25 ± 0.96 0.93 ± 0.7 3h-56-202 0.6±0·2 39.0 ±16.0 50 ± 9.8 2.9 ± 2.6 3h-56-203 0.45 ±0.1 51.0 ±29.0 52 ±23 3,7 ±4.0 3h-56-206 0.1 ±0.01 6.0 ± 2.0 5·25 ± 0.5 0.7± 0.4 3h-56-215 0_2 ± 0·03 41.0 土 15.0 31 ±7 11.0±12.0 3h-56-217 0.1 ±0.04 13.0 ±5.0 16 ±6.7 9.4 ± 8.0 3h-56-224 0.5 ± 0.2 26.0 ± 5.0 47 士 11 18.0 ±22.0 3h-56-232 0.27 ±0.1 37.0 ± 0.7 42± 10 7.3 ± 6.6 3h-56-239 0.11 ±0.0 18.0 ±4.0 13.5 ±4.76 5.8 ± 6.5 3h-56-243 0.15 ±0.007 13.5 ±2.0 14.2 ± 4.6 8.8 ± 10.0 3h-56-244 0.17 ±0.02 26.0 ±3.0 21 ±4.1 12.6 ±16.0 3h-56-246 0.24 ± 0.06 34.0 ± 14.0 23.8 ± 6.2 23.2 ± 22.0 3h-56-248 0.36 ±0.1 3h-56-253 0.4 ± 0_2 3h-56-258 0.079 土 0.003 11.0 ±3.0 8.7 ±1.9 1.52 ± 1.6 3h-56-261 0.17 ±0.09 25.5 ± 6.0 17 士 5.4 3.0±1.8 3h-56-262 0.31 ±0.007 3h-56-265 0.36 ±0.06 3h-56-266 0.19 ±0.04 19.5 ±6.0 13.8 ± 2.4 2.8 ±2.3 3h-56-269 0.14 ±0.02 15.0 ±5.0 9.7 ± 1.9 1_8± 1.2 3h-56-270 0.31 士 0.1 3h-56-5 6.0 ± 4.0 >7000 3h-56-6 4.0 ±3.0 3h-56-7 8·0 ± 6.0 3h-56-8 5.0 ±2.0 3h-56-9 3.0 ± 0.6 3h-56-15 2.0 ± 0.9 3h-56-19 3.0 ±2.0
163920.doc -206- 201245225
純系 WZCD40L 驅 動之人類B 細胞增殖 EC5〇 (nM) WZCD40L 驅 動夂獼猴Β 細孢增殖 EC5〇 (nM) CHO-hCD40L 驅 動之人類B 細胞增殖 EC5〇 (nM) T-B細胞 MLR EC5〇 (nM) CHO-hCD40L 驅 動之DC活化 IL-12 EC5〇 (nM) 3h-56-21 2.0 ± 1.0 3h-131 2700.0 土 1000.0 >7000 3h-131-2 55.0 ±53.0 >7000 3h-131-6 141.0 ±37.0 3h-131-14 24.0 ±4.0 3h-193 >7000 3h-193-12 277.0 ± 167.0 3h-193-16 387.0 ± 173.0 3h-193-19 233.0 ± 110.0 3h-193-25 303.0 ± 214.0 2200.0 士 1200.0 3h-193-29 1380.0 ± 721.0 3h-198 554.0 ± 186.0 >7000 3h-198-l 64.0 ± 47.0 3h-198-2 207.0 ± 158.0 3h-198-5 9.0 ± 6.0 3h-198-19 19.0 ± 14.0 3h-198-24 34.0 ±37.0 3h-198-28 20.0 ±9.0 3h-202 6400.0 ± 1300.0 >7000 3h-202-l 192.0 ±77.0 >7000 3h-202-5 6500.0 士 1000.0 3h-202-10 289.0 ± 158.0 3h-202-ll 201.0 ± 103.0 3h-217 3200.0 ± 2030.0 >7000, 5300, 1690 3h-217-l 45.0 ±26.0 35.0 土 8.0 3h-217-2 8.0 ±4.0 7.0 335.0 3h-217-4 61.0 ±20.0 27.0 3h-217-5 13.0 ±5.0 15.0 3h-217-6 11·0±3.0 10.0 3h-217-7 220.0 ± 20.0 3h-217-8 33.0 ± 10.0 14.0 163920.doc -207- 201245225
純系 MZCD40L 驅 動之人類B 細胞增殖 ECs〇 (nM) hIZCD40L 驅 動之獼猴B 細胞增殖 ECs〇 (nM) CHO-hCD40L 驅 動之人類B 細胞增殖 EC5〇 (nM) T-B細胞 MLR ECso (nM) CHO-hCD40L 驅 動之DC活化 IL-12 ECso (nM) 3h-217-9 380.0 ± 170.0 3h-217-14 26.0 ± 10.0 8.0 3h-217-15 47.0 ±21.0 20.0 3h-217-16 5.0 ±2.0 7.0 1125.0 3h-217-17 1950.0 ± 110.0 3h-217-23 16.0 ±6.0 15.0 3h-217- 2305 11.0 ±4.0 3h-217-30 80.0 ± 9_0 >7700 3h-217-31 >700.0 3h-231 328.0 ± 144.0 >7000 3h-233 184.0 ±75.0 >7000 1492.0， >2000 3h-240 >7000 >7000 3h-242 219.0 ±53.0 435.0 ±62.0 2050.0 3h-257 135.0 ±28.0 >7000 704.0 土 445.0 3h-262 548.0 ± 121.0 >700 998.0 3h-263 >700.0 >700 3h-264 1200.0 ± 400.0 >7000 >2000 3h-265 2400.0 土 1000.0 >7000 >2000 3h-271 295.0 ± 92.0 446.0 >2000 3h-274 1200, >7000 >7000 3h-275 157.0 ± 11.0 >7000 3h-285 49.0 ± 0.7 155.0 3h-287 287.0 土 156.0 918.0 3h-289 2300.0 ± 1200.0 4300.0 3h-290 >7000 5650.0 3h-294 >7000 >7000 3h-295 >7000 >7000 3h-296 306.0 ±55.0 >7000 3h-309 648.0 ± 268.0 838.0 3h-312 1100.0 土 346.0 >7000 163920.doc -208· 201245225 實例7 結合CD40及血清白蛋白之雙特異性dAb 構築特異性結合CD40及人類血清白蛋白（HSA)或獼猴血 清白蛋白（CSA)之雙特異性dAb且在基於細胞之分析中測 試其活性。白蛋白特異性dAb稱為「AlbudAb」。在此實例 中，AlbudAb融合物包含結合CD40之BMS3h dAb及識別 HSA之另一域抗體DOM7h。將兩種dAb在框架中融合至胺 基酸連接子之胺基及羧基末端以形成串聯融合（inline fusion，ILF)多肽。ILF多肽以重組方式表現為單一融合蛋 白。表明AlbudAb IL.F之活性的RBA描述於下文，且結果 示於表18中。表19概述所測試AlbudAb ILF中所用之連接 子序列。藉由BIAcoi eTM分析測定之動力學結合資料示於 表20中。 在上清液中偵測dAb之人類CD40 CHO細胞ELISA : 使用0.25%胰蛋白酶EDTA自細胞培養燒瓶分離穩定轉染 之表現人類CD40之CHO-DG44細胞或天然CHO-DG44細胞 (皆為BMS)，且將每孔100,000個細胞於生長培養基中接種 至96孔組織培養物處理之培養盤（NUNC)中。在37°C、5% co2下，在濕潤氛圍中使細胞黏附隔夜。分析當天，用 PBS洗滌細胞片，隨後用2%三聚曱醛（Sigma-Aldrich)固定 20分鐘。固定之後，再用PBS洗滌細胞片，隨後用含15% 胎牛血清（FBS，PAA)之PBS阻斷1小時。再洗滌培養盤一 次，隨後添加每孔100 μΐ dAb上清液且在室溫下培育2小 時。用細胞培育dAb上清液之後，洗滌培養盤且視dAb為 163920.doc -209- 201245225 VH或VL域而定由培育辣根過氧化物酶（HRP)結合物抗蛋白 質A或L來偵測dAb結合。在用1M HC1中和之後，使用 SpectraMax M5e培養盤讀取器（Molecular Devices)在 450 nm下量測吸光度信號。 ICAM-1上調細胞分析： 使用凡爾生（Invitrogen)自細胞培養燒瓶分離穩定轉染之 表現人類CD40L之COS細胞。將每孔20,000個細胞於分析 緩衝液（無酚紅（Sigma-Aldrich，UK)+l°/〇青黴素/鏈黴素+ 10〇/〇 FBS Gold (皆來自 PAA Laboratories, UK)之 RPMI 1640)中接種至96孔高結合黑壁透明底培養盤（Corning， UK)中。在37t及5% C02下，在濕潤氛圍中使細胞黏附隔 夜。第二天，用100 μΐ新鮮分析緩衝液補充含有非附著細 胞之廢分析緩衝液。為此，除稀釋範圍之dAb之外，在分 析緩衝液中添加每孔20,000個RAMOS細胞。將分析培養盤 再放回37°C及5% C02下之濕潤氛圍中24小時。對於陰性對 照孔，不添加RAMOS細胞。dAb抑制RAMOS細胞之細胞 表面上的ICAM-1響應暴露於COS細胞之細胞表面上的 CD40L而上調之能力藉由添加0.5 pg/ml小鼠抗人類ICAM-1抗體（R&D systems)及 0.2 pg/ml山羊抗小鼠 ALEXA flour 647 (Invitrogen，Molecular probes, UK)來評估。在無燈存 在下3小時培育期之後，如由AB8200細胞偵測平台 (Applied Biosystems)所量測來偵測相對螢光。 結合至血清白蛋白之串聯融合(1LF)動力學分析 使用 BIAcoreTM 3000儀器（GE Healthcare)分析抗 CD40- 163920.doc -210- 201245225
AlbudAb ILF對人類及獼猴血清白蛋白之結合動力學。使 用胺偶合套組（GE Healthcare)將約400反應單位（RU)之人 類血清白蛋白（HSA)或獼猴血清白蛋白（CSA)固定於CM5 BIAcoreTM晶片之流槽上。將未固定有任何配位體之第二 流槽用作參比流槽進行線内參比。用HBS-EP緩衝液（具有 0· 15 M NaCl、3 mM EDTA及 0.005% v/v界面活性劑 P20之 0.01 M HEPES (pH 7.4)，GE Healthcare)製備一系列適當 二倍稀釋之各待分析之dAb。使用儀器之KINJECT功能一 式兩份注射兩種100微升各ILF。在串聯之固定血清白蛋白 之流槽及參比流槽上進行注射，線内減去來自參比槽之信 號。在25°C及40 μΐ/inin之HBS-EP流速下執行實驗》各注 射完成後，允許在緩衝液中自配位體解離dAb 120秒，隨 後由注射10 μΐ 10 mM甘胺鲮（pH 2.0)而再生》亦在相同條 件下注射HBS-EP緩衝液空白參比注射劑（不包含分析物）， 以用作自各分析物跡線減去之第二參比。使用BIAevaluation 4.1軟體（GE Healthcare)自各分析物跡線減去參比流槽跡線 與緩衝液空白跡線。使用同一軟體同時整體擬合分析物稀 釋液系列跡線之締合及解離階段的1:1 (朗繆爾）動力學模 型。此模型產生相互作用之締合及解離速率常數（分別為h 及免d)及平衡解離常數〇S：D)。參數值示於表20中。 163920.doc • 211 · 201245225 ICAM_1細胞分析 ECso (nM) 10%人血清 >1000 >1000 >1000 20.35 39.2 74.2 53.3 94.8 50.9 74.3 62.4 66.6 10°/。胎牛血清 33.5 21.4 16.5 21.7 21.7 39.3 43.6 10.2 32.4 37.9 31.9 I 48.3 < S I e ^ O 0 υ V w o » υ 50 μΜ HSA oo 卜 (N 26.8 16.6 Os cn rn cn 卜 0.1% BSA m OO OO vd 12.2 (N 21.8 — C端 dAb DOM7h-ll-3 DOM7h-ll-87 DOM7h-ll-3 DOM7h-ll-87 BMS3h-56-201 BMS3h-56-201 BMS3h-56-258 BMS3h-56-258 BMS3h-56-201* BMS3h-56-201 BMS3h-56-201 BMS3h-56-258 BMS3h-56-258 BMS3h-56-258 BMS3h-56-258 DOM7h-ll-90 DOM7h-ll-90 DOM7h-ll-90 DOM7h-ll-90 DOM7h-ll-90 連接子 AST AST AST AST TVAAPS TVAAPS TVAAPS TVAAPS TVAAPS TVAAPS TVAAPS TVA CO d d \r> d TVA ASTSGPS C/D d d d N端 dAb BMS3h-56-201 BMS3h-56-201 BMS3h-56-258 BMS3h-56-258 DOM7h-ll-3 DOM7h-11-87 DOM7h-ll-3 DOM7h-11-87 DOM7h-11-90 DOM7h-11-86 DOM7h-ll-69 DOM7h-ll-90 DOM7h-ll-90 DOM7h-ll-90 DOM7h-ll-90 BMS3h-56-258 BMS3h-56-258 BMS3h-56-258 BMS3h-56-258 BMS3h-56-258 DMS編號 DMS0654 DMS0655 DMS0656 DMS0657 DMS0658 DMS0659 DMS0660 DMS0661 DMS0662 DMS0663 DMS0664 DMS0677 DMS0679 DMS0680 DMS0681 DMS0682 DMS0683 DMS0684 DMS0685 DMS0686
163920.doc -212- 201245225
瓦畋屮璁钾Μι V 6Ι<
SEQ ID NO: 5 SEQ ID NO: 6 SEQ ID NO: 7 SEQ ID NO: 1207 SEQ ID NO: 1208 SEQ ID NO: 1209 SEQ ID NO: 8 AST TVAAPS TVA GGGGS (ggggs)3 (ggggs)5 ASTSGPS 军^SISSVIS 0<N< 獼猴血清白蛋白 KD(nM) 2.79,1.21 0.83 (N yn (N <N in <N OO <N 1.09,2.97 Ό X 2.37, 3.37,2.4 VO v〇 <N ri CN 2.81,2.96 CN r^T (N K (1/Ms) xl〇·6 0.85, 2.79,2.9 1.01，1.10 OO OO (N OS 〇 (N 人類血清白蛋白 i [D(nM) 1.37, 0.60, 0.45 1.21,1.23 1.12,1.21 0.57,1.59 1.17， 1.69,1.2 1.33,1.47 〇Λ 1.42, 1.49 ka (1/Ms) xlO*6 0.85, 2.85,,2.6 1.1, 1.19 (N cn cs CO ON o (N C端 dAb BMS3h- 56-201 BMS3h- 56-201 BMS3h- 56-201 BMS3h- 56-201 赶二: 'f! 〇 CL| Η' ^ 5 g ^ 〇t έ长 TVAAPS TVAAPS TVAAPS TVAAPS N 端 dAb DOM7h-11-87 DOM7h-ll-90 DOM7h-ll-86 DOM7h-ll-69 DMS編號 DMS0659 DMS0662 DMS0663 DMS0664 163920.doc •213 201245225 表21列出可特異性結合CD40及HSA或CSA之代表性
AlbudAb ILF之胺基酸序列。各ILF之名稱鑑別特定連接子 序列：「GxS」意謂連接子具有「X」個甘胺酸殘基之後為 絲胺酸，且「（GxS)y」意謂連接子具有y個GxS之重複單 元。表22揭示編碼表21中所列之ILF序列之代表性核酸。 如此項技術中所熟知，多個密碼子可編碼同一胺基酸。因 此，編碼蛋白質序列之核酸包括具有密碼簡併性之核酸。 表21 雙特異性dAb胺基酸序列 (表21揭示分別如SEQ ID NO 5至7、1207至1209及8所示 之「AST」、「TVAAPS」、「TVA」、「G4S」、「（G4S)3」、 「（G4S)5」及「ASTSGPS」） DMS0654 BMS3h-56-201-AST-DOM7h-ll-3 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSSAS TDIQMTQSPSSLSASVGDRVTITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGV PSRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO: 1210) DMS0655 BMS3h-56-201-AST-DOM7h-ll-87 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSSAS TDIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGV PSRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHHTTFGQGTKVEIKR (SEQ ID NO: 1211) DMS0656 BMS3h-56-258-AST-DOM7h-ll-3 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSSAS TDIQMTQSPSSLSASVGDRVTITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGV PSRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO: 1212) DMS0657 BMS3h-56-258-AST-DOM7h-ll-87
EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY
YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSSAS
TDIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGV -214-
163920.doc 201245225 PSRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHHTTFGQGTKVEIKR (SEQ ID NO: 1213) DMS0658 DOM7h-ll-3-1VAAPS-BMS3h-56-201 DIQMTQSPSSLSASVGDRVIITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGVP SRFSGSGSGTDFTLTISS.LCPEDFATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCA^SGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQNNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSS (SEQ ID NO: 1214) DMS0659 D〇M7h-ll-87-TVAAPS—BMS3h—56—201 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISSLCPEDFATYYCAQAGTHHTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSS' (SEQ ID NO: 1215)
DMS0660 DOM7h-ll-3-TVAAPS-BMS3h-56-258 DIQMTQSPSSLSASVGDRVTITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGVP SRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSS (SEQ ID NO: 1216) DMS0661 DOM7h-ll-87-TVAAPS-BMS3h-56-258 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHHTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSS (SEQ ID NO: 1217) DMS0662 DOM7h-ll-90-TVAAPS-BMS3h-56-201 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISMLQPEDFATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQWNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSS (SEQ ID NO: 1218) DMS0663 DOM7h-ll-86-TVAAPS-BMS3h-56-201 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISSLQPEDVATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQWNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSS (SEQ ID NO: 1219) DMS0664 DOM7h-ll-69-TVAAPS-BMS3h-56-201 215- 163920.doc 201245225 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGVHPTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFQEWGQGTLVTVSS (SEQ ID NO: 1220) DMS0667 DOM7h-ll-3-TVAAPS-BMS3h-38-240 DIQMTQSPSSLSASVGDRVTITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGVP SRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 1221) DMS0668 BMS3h-38-240-AST-DOM7h-ll-3 EVQLLESGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSSAS TDIQMTQSPSSLSASVGDRVTITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGV PSRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO: 1222) DMS0669 DOM7h-14-10-TVAAPS-BMS3h-38-240 DIQMTQSPSSLSASVGDRVTITCRASQWIGSQLSWYQQKPGKAPKLLIMWRSSLQSGVP SRFSGSGSGTDFTLTISSLQPEDFATYYCAQGLRHPKTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 1223) DMS0670 BMS3h-38-240-AST-DOM7h-14-10 EVQLLESGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYeGKEPFRYDYWGQGTLVTVSSAS TDIQMTQSPSSLSASVGDRVTITCRASQWIGSQLSWYQQKPGKAPKLLIMWRSSLQSGV PSRFSGSGSGTDFTLTISSLQPEDFATYYCAQGLRHPKTFGQGTKVEIKR (SEQ ID NO： 1224) DMS0671 BMS3h-38-235-AST-DOM7h-ll-3 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSSAS TDIQMTQSPSSLSASVGDRVTITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGV PSRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO: 1225) DMS0672 BMS3h-38-235-AST-DOM7h-ll-90 EVQLLASGGGLVQPGGSLRLSCAASGFTFEEEEMIWRQAPGKGLEWVSAISRNGYSTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSSAS TDIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGV PSRFSGSGSGTDFTLTISNLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO: 1226) 216·
163920.doc 201245225 DMS0674 DOM7h-ll-3-TVAAPS-BMS3h-38-235 DIQMTQSPSSLSASVGDRVTITCRASRPIGTTLSWYQQKPGKAPKLLILWNSRLQSGVP SRFSGSGSGTDFTLTISSLQPEDFATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LASGGGLVQPGGSLRLSCAi.SGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 1227) DMS0675 DOM7h-ll-90-TVAAPS-BMS3h-38-235 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISNLCiPEDFATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LASGGGLVQPGGSLRLSCAASGFTFEEEEMIWVRQAPGKGLEWVSAISRNGYSTYYADS VKGRFTISRDNSKNTLYLQWNSLRAEDTAVYYCGKEPFRYDYWGQGTLVTVSS (SEQ ID NO: 1228.) DMS0677 DOM7h-ll-90-TVA-BMS3h-56-258
DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISNLQPEDFATYYC雖GTHPTTFGQGTKVEIKRTVAEVQLLES GGGLVQPGGSLRLSCAASGETFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSVKG RFTISRDNSKNTLYLQMNS1.RAEDTAVYYCAKLPFYFHEWGQGTLVTVSS (SEQ ID NO: 1229) DMS0678 DOM7h-ll-90-ASTSGPS-BMS3h-56-258 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISNLC!PEDFATYYCAQAGTHPTTFGQGTKVEIKRASTSGPSEVQ LLESGGGLVQPGGSLRLSC^ASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYAD SVKGRFTISRDNSKNTLYLClMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSS* (SEQ 工D NO: 1230) DMS0679 DOM7h-ll-90-G4S-BMS3h-56-258 DIQMTQSPSSLSASVGDRVIITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISNLCPEDFATYYCAQAGTHPTTFGQGTKVEIKRGGGGSEVQLL ESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADSV KGRFTISRDNSKNTLYLQMFSLRAEDTAVyyCAKLPFYFHEWGQGTLVTVSS (SEQ ID NO: 1231) DMS0680 DOM7h-ll-90-' (G4S) 3-BMS3h-56-258 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISNLClPEDFATYYCAQAGTHPTTFGQGTKVEIKRGGGGSGGGGS GGGGSEVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQ GTRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVT VSS (SEQ ID NO: 1232) DMS0681 DOM7h-ll-90-(G4S)5-BMS3h-56-258
DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP
SRFSGSGSGTDFTLTISNLClPEDFATYYCAQAGTHPTTFGQGTKVEIKRGGGGSGGGGS
GGGGSGGGGSGGGGSEVQLI.ESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKG 217· 163920.doc 201245225 LERVSAINPQGTRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYF HEWGQGTLVTVSS (SEQ ID NO: 1233) DMS0682 BMS3h-56-258-TVA-DOM7h-ll-90 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSSTV ADIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGV PSRFSGSGSGTDFTLTISNLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO: 1234) DMS0683 BMS3h-56-258-ASTSGPS-DOM7h-ll-90 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSSAS TSGPSDIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRL QSGVPSRFSGSGSGTDFTLTISNLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO: 1235) DMS0684 BMS3h-56-258-G4S-DOM7h-ll-90 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSSGG GGSDIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQS GVPSRFSGSGSGTDFTLTISNLQPEDFATYYCAQAGTHPTTFGQGTKVEIKR (SEQ ID NO： 1236) DMS0685 BMS3h-56-258-(G4S)3-DOM7h-ll-90 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSSGG GGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKL LILAFSRLQSGVPSRFSGSGSGTDFTLTISNLQPEDFATYYCAQAGTHPTTFGQGTKVE IKR (SEQ ID NO: 1237) DMS0686 BMS3h-56-258-(G4S)5-DOM7h-ll-90 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTY YADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSSGG GGSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWY QQKPGKAPKLLILAFSRLQSGVPSRFSGSGSGTDFTLTISNLQPEDFATYYCAQAGTHP TTFGQGTKVEIKR (SEQ ID NO: 1238) ， DMS0688 DOM7h-ll-90-TVAAPS-BMS3h-56-258 DIQMTQSPSSLSASVGDRVTITCRASRPIGTMLSWYQQKPGKAPKLLILAFSRLQSGVP SRFSGSGSGTDFTLTISNLQPEDFATYYCAQAGTHPTTFGQGTKVEIKRTVAAPSEVQL LESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSAINPQGTRTYYADS VKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLPFYFHEWGQGTLVTVSS (SEQ' ID NO:. 1239) 表22 編碼雙特異性dAb之聚核苷酸 (表22揭示分別如SEQ ID NO 5至7、1207至1209及8所示 之「AST」、「TVAAPS」、「TVA」、「G4S」、「（G4S)3」、 「（G4S)5」及「ASTSGPS」） -218-
163920.doc 201245225 DMS0654 BMS3h-56-201-A£T-D0M7h-ll-3 GAGGTGCAGCTGTTGGAGTCTGG；GGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGTGCAGCCTCCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG TTTTACTTTCAGGAGTGGGGTCi.GGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCGAC ATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGAl'TGGGACGACGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCTTTGGAATTCCCGTTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGAC：AGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAA GATTTTGCTACGTACTACTGTGC：GCAGGCTGGGACGCATCCTACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG (SEQ ID NO: 1240} DMS0655 BMS3h-56-201-AST-DOM7h-ll-87
GAGGTGCAGCTGTTGGAGTCTGC；GGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGTGCAGCCTCCGGATTCAC：CTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGCGGGICTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAATGAACAGCCTGCGTGC：CGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG TTTTACTTTCAGGAGTGGGGTCi.GGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCGAC ATCCAGATGACCCAGTCTCCATC：CTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGAI'TGGGACGATGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCa'TGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGAC：AGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAA GATTTTGCTACGTACTACTGTGC：GCAGGCTGGGACGCATCATACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG <SEQ ID NO: 1241) DMS0656 BMS3h-56-258-A£：T-DOM7h-ll-3 GAGGTGCAGCTGTTGGAGTCTGC；GGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGTGCAGCCTCCGGATTCAC：CTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAATGAACAGCCTGCGTGC：CGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG TTTTACTTTCACGAGTGGGGTC；iGGG7^ACCCTGGTCACCGTCTCGAGCGCTAGCACCGAC ATCCAGATGACCCAGTCTCCATC：CTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGATTGGGACGACGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCl.^TGGAATTCCCGXTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGAC：AGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAA GATTTTGCTACGTACTACTGTGC：GCAGGCTGGGACGCATCCTACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG 丨:SEQ ID NO: 1242) 219- 163920.doc 201245225 DMS0657 BMS3h-56-258-AST-DOM7h-ll-87 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGTGCAGCCTCCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGT^ACACGCTGTAT CTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG TTTTACTTTCACGAGTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCGAC ATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAA GATTTTGCTACGTACTACTGTGCGCAGGCTGGGACGCATCATACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG (SEQ ID NO： 1243) DMS0658 DOM7h-ll-3-TVAAPS-BMS3h-56-201 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGACGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTTGGAATTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT GAAGATTTTGCTACGTACTACTGTGCGCAGGGTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA TTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG CGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCAGGAGTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1244) DMS0659 DOM7h-ll-87-TVAAPS-BMS3h-56-201 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT GAAGATTTTGCTACGTACTACTGTGCGCAGGCTGGGACGCATCATACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA TTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG CGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC • CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCAGGAGTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1245) DMS0660 DOM7h-ll-3-TVAAPS-BMS3h-56-258
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC
ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGACGTTAAGTTGGTACCAGCAGAAACCA
GGGAAAGCCCCTAAGCTCCTGATCCTTTGGAATTCCCGTTTGCAAAGTGGGGTCCCATCA
CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT
GAAGATTTTGCTACGTACTACTGTGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA
GGGACC7U\GGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG
TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA
TTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG
CGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC
CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG
CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGTGG 220·
163920.doc 201245225 GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO： 1246) DMS0661 DOM7h-ll-8*7-TVAAPS-BMS3h-56-258 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTXCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT GAAGATTTTGCTACGTACTACTGTGCGCAGGCTGGGACGCATCATACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA TTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG CGGGTCTCAGCTATTAATCCGCPGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1247) DMS0662 DOM7h-ll-90-TV^APS-BMS3h-56-201
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT GAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG TCCGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA TTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG CGGGTCTCAGCTATTAATCCGCA.GGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACMTTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCAGGAGTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1248) DMS0663 DOM7h-ll-86-TViAPS-BMS3h-56-201 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGA1CCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT GAAGATGTTGCTACGTACTACTG-TGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA TTCACCTTTCGGGATTATGAGA1GTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG CGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACM.TTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGACACCGCGGTAW.TTACTGTGCGAAACTTCCGTTTTACTTTCAGGAGTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1249) DMS0664 DOM7h-ll-69-TViAPS-BMS3h-56-201
GACATCCAGATGACCCAGTCTCC：ATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC
ATCACTTGCCGGGCAAGTCGTCC：GATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA
GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAT^AGTGGGGTCCCATCA
CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT
GAAGATTTTGCTACGTACTACTC；TGCGCAGGCtGGGGTGCATCCTACGACGTTCGGCCAA
GGGACCAAGGTGGAAATCAAACC；TACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG
TCTGGGGGAGGCTTGGTACAGCC：TGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA
TTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG 221- 163920.doc 201245225 CGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCAGGAGTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC {SEQ ID NO: 1250) DMS0667 DOM7ii-ll-3-TVAAPS-BMS3h-38-240 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGACGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTTGGAATTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT GAAGATTTTGCTACGTACTACTGTGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGCGCAGCCTCCGGA TTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG TGGGTCTCAGCTATTAGTAGGAACGGTTACAGCACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1251) DMS0668 BMS3h-38-240-AST-DOM7h-ll-3 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGCGCAGCCTCCGGATTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTAGGAACGGTTACAGCACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCG TTTCGTTATGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCGAC ATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGATTGGGACGACGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCTTTGGAATTCCCGTTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAA GATTTTGCTACGTACTACTGTGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG {SEQ ID NO: 1252> DMS0669 DOM7h-14-10-TVAAPS-BMS3h-38-240 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCAGTGGATTGGGTCTCAGTTATCTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCATGTGGCGTTCCTCGTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT GAAGATTTTGCTACGTACTACTGTGCTCAGGGTTTGAGGCATCCTAAGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGCGCAGCCTCCGGA TTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG TGGGTCTCAGCTATTAGTAGGAACGGTTACAGCACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1253) DMS0670 BMS3h-38-240-AST-D0M7h-14-10
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC
TCCTGCGCAGCCTCCGGATTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCT
CCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTAGGAACGGTTACAGCACATACTAC
GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT
CTGCAAATGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCG 222-
163920.doc 201245225 TTTCGTTATGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCGAC ATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCAGTGGA^TGGGTCTCAGTTATCTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCA^GTGGCGTTCCTCGTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAA GATTTTGCTACGTACTACTGTGCTCAGGGTTTGAGGCATCCTAAGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG (SEQ ID NO: 12.54) DMS0671 BMS3h-38-235-A：5T-DOM7h-ll-3 GAGGTGCAGCTGTTGGCGTCTG(；GGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGCGCAGCCTCCGGATTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTAGGAACGGTTACAGCACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAAXGAACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCG TTTCGTTATGACTACTGGGGTCi^GGGAACCCTGGTCACCGTCTCGAGCGCTTCAACCGAC ATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGATTGGGACGACGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCTTTGGAATTCCCGTTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAA GATTTTGCTACGTACTACTGTGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG (SEQ ID NO: 1255)
DMS0672 BMS3h-38-235-A：3T-DOM7h-ll-90 GAGGTGCAGCTGTTGGCGTCTG(3GGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGCGCAGCCTCCGGATTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCC CCAGGGAAGGGTCTAGAGTGGGTCTCAGCTATTAGTAGGAACGGTTACAGCACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAATG7VACAGCCTGCGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCG TTTCGTTATGACTACTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGCTTCAACCGAC ATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCTGAA GATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG (SEQ ID NO: 1256) DMS0674 DOM7h-ll-3-TVAAPS-BMS3h-38-235 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGACGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTTGGAATTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGiSGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCT GTVAGATTTTGCTACGTACTACTiSTGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGGACCGTGGCGGCGCCGAGTGAGGTGCAGCTGTTGGCG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGCGCAGCCTCCGGA TTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG TGGGTCTCAGCTATTAGTAGGA^CGGTTACAGCACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACA.^TTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1257) DMS0675 DOM7h-ll-90-TVAAPS-BMS3h-38-235
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC
ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA 223· 163920.doc 201245225 GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT GAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGGACCGTGGCGGCGCCGAGTGAGGTGCAACTGTTGGCG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGCGCAGCCTCCGGA TTCACCTTTGAGGAGGAGGAGATGATTTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG TGGGTCTCAGCTATTAGTAGGAACGGTTACAGCACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGATACCGCGGTATATTACTGTGGGAAAGAGCCGTTTCGTTATGACTACTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1258) DMS0677 DOM7h-ll-90-TVA-BMS3h-56-258 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT GAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGA^TCAAACGTACGGTGGCGGAGGTGCAGCTGTTGGAGTCTGGGGGA GGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGATTCACCTTT CGGGATTATGAGATGTGqTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGGGTCTCA GCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGGTTCACC ATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGCGTGCCGAG GACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGTGGGGTCAGGGA ACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1259) DMS0678 DOM7h-ll-90-ASTSGPS-BMS3h-56-258 GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT GAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGGGCTAGCACCTCAGGTCCATCGGAGGTGCAGCTGTTG GAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCC GGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTA GAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAG GGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGC CTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAG TGGGGTCAGGGAACCCTGGTCACCGTCTCCAGC {SEQ ID NO: 1260)
DMS0679 DOM7h-ll-90-G4S-BMS3h-56-25B GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT GAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGGGGTGGAGGTGGCTCTGAGGTGCAGCTGTTGGAGTCT GGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGATTC ACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGG GTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGG TTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGCGT GCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGTGGGGT CAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1261) •224·
163920.doc 201245225 DMS0680 DOM7h-ll~90- (C；4S) 3-BMS3h-56-258
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC
ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA
GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA
CGTTTCAGTGGCAGTGGATCTCJGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT
GAAGATTTTGCTACGTACTAC^'GCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA
GGGACCAAGGTGGAAATCAAACGGGGTGGAGGTGGCTCTGGAGGTGGCGGTAGCGGCGGA
GGCGGTTCAGAGGTGCAGCTGrj,TGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCC
CTGCGTCTCTCCTGTGCAGCCl'CCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTC
CGCCAGGCTCCAGGGAAGGGTC：TAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGT
ACATACTACGCAGACTCCGTGiJVGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAAC
ACGCTGTATCTGCAAATGAAC7^GCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCG AAACTTCCGTTTTACTTTCACGAGTGGGGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ 1° NO: 1262) DMS0681 DOM7h-ll-90- (G；4S) 5-BMS3h-56-258
GACATCCAGATGACCCAGTCTC：CATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC ATCACTTGCCGGGCAAGTCGTC：CGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA GGGAAAGCCCCTAAGCTCCTGi.TCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT GAAGATTTTGCTACGTACTAC1GCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGGAAATCAAACGGGGTGGAGGTGGCTCTGGAGGTGGCGGTAGCGGCGGT GGCGGTTCAGGTGGCGGAGGTICTGGAGGCGGTGGATCTGAGGTGCAGCTGTTGGAGTCT GGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGATTC ACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAGCGG GTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGCCGG TTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGCGT GCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGTGGGGT CAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO: 1263) DMS0682 BMS3h-56-258-TVA-DOM7h-ll-90 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGTGCAGCCTCCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG TTTTACTTTCACGAGTGGGGTCAGGGAACCCTGGTCACCGTTTCGAGCACGGTGGCGGAC ATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATC ACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCAGGG AAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCACGT TTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCTGAA GATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAAGGG ACCAAGGTGGAAATCAAACGG (SEQ ID NO: 1264) DMS0683 BMS3h-56-258-ASTSGPS-DOM7h-ll-90
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC
TCCTGTGCAGCCTCCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT
CCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC
GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT
CTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG
TTTTACTTTCACGAGTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCTCA
GGTCCATCGGACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGAC
CGTGTCACCATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAG
CAGAAACCAGGGAAAGCCCCTA?VGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGG 225- 163920.doc 201245225 GTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAAT CTGCAACCTGAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACG TTCGGCCAAGGGACCAAGGTGGAAATCAAACGG (SEQ ID NO: 1265) DMS0684 BMS3h-56-258-G4S-DOM7h-ll-90 GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC TCCTGTGCAGCCTCCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT CCAGGGAAGGGTCTAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTAT CTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCG7UVACTTCCG TTTTACTTTCACGAGTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGC TCTGACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTC ACCATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAA CCAGGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCA TCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAA CCTGAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGC CAAGGGACCAAGGTGGAAATCAAACGG (SEQ ID NO: 1266) DMS0685 BMS3h-56-258-(G4S)3-D0M7h-ll-90
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC
TCCTGTGCAGCCTCCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT
CCAGGG7VAGGGTCTAGAGCGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTAC
GCAGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAATTCCAAG7VACACGCTGTAT
CTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG
TTTTACTTTCACGAGTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGTGGC
TCTGGAGGTGGCGGTAGCGGCGGTGGCGGTTCAGACATCCAGATGACCCAGTCTCCATCC
TCCCTGTCTGCATCTGTAGGAGACCGTGTCACCATCACTTGCCGGGCAAGTCGTCCGATT
GGGACGArGTTAAGTTGGTACCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCCTT
GCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCACGTTTCAGTGGCAGTGGATCTGGGACA
GATTTCACTCTCACCATCAGCAATCTGCAACCTGT^AGATTTTGCTACGTACTACTGCGCG
CAGGCTGGGACGCATCCTACGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAACGG (SEQ ID NO: 1267) DMS0686 BMS3h-56-258-(G4S)5-DOM7h-ll-90
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTC
TCCTGTGCAGCCTCCGGATTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCT
CCAGGGT^AGGGTCTAGAGCGGGTCXCAGCTATTAATCCGCAGGGTACGCGTACATACTAC gcagactccgtgaagggccggttcaccatctcccgcgAcaattccaagaacacgctgtat CTGCAAATGAACAGCCTGCGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCG TTTTACTTTCACGAGTGGGGTCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGTGGC TCTGGAGGTGGCGGTAGCGGCGGTGGCGGTTCAGGTGGCGGAGGTTCTGGAGGCGGTGGA TCTGACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTC ACCATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAA CCAGGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCA TCACGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAA CCTGAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGC CAAGGGACCAAGGTGGAAATCAAACGG {SEQ ID NO: 1268) DMS0688 DOM7h«ll-90-TVAAPS-BMS3h-56-258
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACCGTGTCACC
ATCACTTGCCGGGCAAGTCGTCCGATTGGGACGATGTTAAGTTGGTACCAGCAGAAACCA
GGGAAAGCCCCTAAGCTCCTGATCCTTGCTTTTTCCCGTTTGCAAAGTGGGGTCCCATCA
CGTTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAATCTGCAACCT GAAGATTTTGCTACGTACTACTGCGCGCAGGCTGGGACGCATCCTACGACGTTCGGCCAA GGGACCAAGGTGG7VAATCAAACGGACCGTAGCGGCGCCGAGTGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGTCTCTCCTGTGCAGCCTCCGGA TTCACCTTTCGGGATTATGAGATGTGGTGGGTCCGCCAGGCTCCAGGGAAGGGTCTAGAG CGGGTCTCAGCTATTAATCCGCAGGGTACGCGTACATACTACGCAGACTCCGTGAAGGGC CGGTTCACCATCTCCCGCGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTG CGTGCCGAGGACACCGCGGTATATTACTGTGCGAAACTTCCGTTTTACTTTCACGAGTGG GGTCAGGGAACCCTGGTCACCGTCTCCAGC (SEQ ID NO： 1269) •226·
163920.doc 201245225 實例8 抗獼猴CD40 dAb 本文所揭示之產生特異性結合人類CD40之抗體多肽之 方法可用以產生特異性結合其他物種之CD40之抗體多 肽。舉例而言，可使用目前揭示之方法產生抗獼猴CD40 (anti-cynomolgus/anti-cyno)抗體多肽。舉例而言，可使用 相同之初始/初步篩檢及親和力成熟流程產生抗獼猴CD40 抗體多肽，作為抗人類CD4〇 dAb。且以下表23中揭示獲 得抗獼猴CD40 dAb之方法且提供抗獼猴CD40 dAb之代表 性實例。 ELISA RBA ·· 在4°C下，透明壁高結合384孔培養盤（Corning, UK)用25 μΐ 1 pg/ml中性鏈親和素於碳酸鹽緩衝液中之溶液塗佈隔 夜。第二天，用0.1%吐溫PBS緩衝液洗滌分析培養盤，在 室溫下用含1% BSA之PBS阻斷1小時，且再次洗滌。移除 過量洗滌緩衝液之後，在室溫下用分析培養盤培育25 μΐ 1 pg/ml生物素標記人類IZ-CD40L (BMS，1.2 mg/ml儲備液濃 度)1小時。同時，稀釋範圍之純化dAb與1 pg/ml獼猴CD40 (BMS)以1:1之比率複合。洗務分析培養盤之後，在室溫 下’在輕微擾動下，在分析培養盤中培育dAb:獼猴CD40 複合物2小時。用辣根過氧化物酶（HRP)結合之抗人類（j?c) 二次抗體（Sigma-Aldiich，UK)偵測dAb相對於獼狼CD40與 生物素標記CD40L之競爭性結合。在用1M HC1中和之後， 在450 nm下，使用Spectromax M5e培養盤讀取器 163920.doc -227- 201245225 (Molecular Devices)量測吸光度信號。 使用AB8200 FMAT之獼猴CD40 CHO細胞RBA : 使用凡爾生（Invitrogen)自細胞培養燒瓶分離穩定轉染之 表現獼猴CD40之CHO-DG44細胞或天然CHO-DG44細胞 (BMS)。將每孔40,000個細胞於具有稀釋範圍之dAb、0·25 pg/ml生物素標記人類IZ-CD40,000L (BMS，1.2 mg/ml儲備 液濃度）及0.25 pg/ml抗生蛋白鏈菌素Alexa Fluor 647 (Invitrogen，Molecular probes，UK)之 0.1% BSA PBS 分析緩 衝液中接種至96孔高結合黑色壁透明底培養盤（Corning, UK)中。在無光存在下培育混合物6小時。培育之後，如用 AB8200細胞偵測平台（Applied Biosystems)所量測，使用 相對螢光評估dAb相對於獼猴CD40 CHO細胞與可溶性生 物素標記IZ-CD40L之競爭性結合。 CHO-hCD40L驅動之初級人類B細胞增殖： 用人類CD40L轉染CHO細胞（ATCC)以產生以較高CD40L 表現程度表現於細胞表面上之穩定細胞株。以1〇,〇〇〇拉德 照射CHOCD40L細胞，隨後用人類B細胞培育。在96孔圆 底培養盤中以每孔200 μΐ之最終體積用1χ103個CHO-CD40L細胞（CHO-CD40L:人類B細胞之比率為1:100)以及不 同滴定量之dAb或單株抗體培育lx 105個扁桃體人類B細 胞。在37°C下培育培養盤72小時，隨後添加胸腺嘧啶核苷 (3H ; 0.5 μ6/孔）6小時。基於胸腺嘧啶核苷併入法定量B 細胞增殖。除非另外說明，否則所有分析均在補充有10% 胎牛血清（FCS)之RPMI培養基中執行。 163920.doc -228· 201245225 可溶性lZ-hCD40L驅動之獼猴脾B細胞增殖： 在96孔圓底培養盤中以每孔200 μΐ之最終體積用0.5 pg/ml IZ-hCD40L以及不同滴定量之dAb或mAb培育ΙχΙΟ5 個自食蟹獼猴脾臟分離之B細胞。在37°C下培育培養盤72 小時，在此之後添加3H-胸腺嘧啶核苷（μ〇ί/孔）6小時。基 於胸腺嘧啶核苷併入法定量B細胞增殖。除非另外說明’ 否則所有分析均在補充有10%胎牛血清（FCS)之RPMI培養 基中執行》
表23 純系 ELISA RB A (nM) 細胞RBA (nM) B細跑增殖分析 (ECso nM) 人類 獼猴 BMS5c8 8,10,12, 8, 8 BMS3c-85 370 >7000、>7000 747、2700、 7000、7000 BMS3C-85-1 52 ' 8 12 2600、1100 18、39、47 BMS3c-85-2 12'4 4、17 1800、800 2、5、6、1 BMS3c-85-3 7 23 >7000、>7000 33 ' 31 ' 21 ' 31 BMS3C-85-8 22 17.2 >7000 > >7000 33、33、25 BMS3c-85-9 10 >7000、>7000 >70 ' >70、104 BMS3c-85-21 11 18 24 BMS3c-85-24 8 13 ' 14 BMS3c-85-25 62 BMS3C-85-26 3 3300、3900 >70 > >70'385 BMS3c-85-27 13 23 39 BMS3c-85-31 13 11 > 9 BMS3c-85-32 21 56 111 BMS3C-85-33 15 10、21.3 17 BMS3C-85-34 48 BMS3c-85-35 19 ' 1.5 >700 2 BMS3c-85-36 - 28 BMS3c-85-37 - 71 BMS3C-85-38 - 17 BMS3c-85-47 2.9 >700 <2 ' 0.5 163920.doc •229· 201245225 純系 ELISA RBA (nM) 細胞RBA (nM) B細胞增殖分析 (EC50 nM) 人類 獼猴 BMS3C-85-49 - 10 >700 3 ' 3 BMS3C-85-51 - 2.5 >700 3 BMS3C-85-52 - 8.5 BMS3C-85-55 - 13.3 、 6.7 >700 3 ' 3 BMS3C-85-56 - 不收斂 BMS3C-85-57 13.8 ' 5.3 >700 2'4 BMS3C-85-62 - 9.9'2.7'2.0 >700 <2、0.63 BMS3C-85-63 80.9 BMS3C-85-64 - 16.1 BMS3C-85-65 - 13.9 ' 7.4 >700 3 ' 2 BMS3c-85-67 - 1.5 0.17 BMS3C-85-69 - 1.8 0.33 BMS3C-85-72 - 2 0.16 BMS3C-85-73 - 2.3 BMS3C-85-77 - 2.3 0.2 BMS3C-85-84 - 1.3 0.21 BMS3C-85-88 - 3 0.25 BMS3C-85-91 - 1.3 0.26
實例9 抗人類CD40 dAb不結合獼猴CD40 如同人類CD40中，但獼猴CD40具有Leul09殘基替代 Trpl09。以下複製長尾獼猴CD40之胺基酸序列： 1 MVRLPLQCVL WGCLLTAVYP EPPTACREKQ YLINSQCCSL CQPGQKLVSD 51 CTEFTETECL PCGESEFLDT WNRETRCHQH KYCDPNLGLR VQQKGTSETD 101 TICTCEEGLH CTSESCESCV PHRSCLPGFG VKQIATGVSD TICEPCPVGF 151 FSNVSSAFEK CRPWTSCETK DLWQQAGTN KTDVVCGPQD RQRALVVIPI 201 CLGILFVILL LVLVFIKKVA KKPNDKVPHP KQEPQEINFP DDLPGSNPAA 251 PVQETLHGCQ PVTQEDGKES RISVQERQ (SEQ IDNO： 2) 使用流式細胞測量方法測試抗人類CD40 dAb與食蟹獼 猴、恆河猴及黑猩猩血液中B細胞及來自狨猿血液之淋巴 細胞之交叉反應性。以下詳述之程序概述用於多個實驗中 偵測CD40 dAb之方法。表24中所示之結果表明抗人類 CD40 dAb不結合獼猴CD40。此情況與上文所揭示之跡象 163920.doc •230· 201245225 (參見圖1及圖2)—致，人類CD40中之Trpl09(獼猴CD40中 不存在）對於dAb與人類CD40之間的複合物形成十分重 要。 方法： 在37°C下用旋轉器使聚乙二醇化抗人類CD40 dAb (BMS3h-56-5C-40L 及 BMS3h38-2C-P40Br)或生物素結合 dAb (BMS3h38-2-生物素）與人類及靈長類動物血液樣品一 起培育1小時。將100 μΐ各血液樣品等分至12x75 mm管中 且用FACS緩衝液（0.5% FBS/PBS/0.1%疊氮化鈉）洗務3次。 在1 500 rpm下將管離心5分鐘，且在洗滌之間傾析上清 液。洗滌之後，將管置於冰上且與人類IgG—起培育5分鐘 以經由Fc受體阻斷非特異性結合。 對於聚乙二醇化dAb偵測，將抗PEG抗體（純系（：11- 2074 ， Silver Lake Research ，或純系 2-2 ， Open
Biosystems)添加至管中且培育30分鐘。用FACS緩衝液洗 滌樣品一次，接著在冰上用APC標記CD20抗體（純系2H7， BD Biosciences)及PE標記抗小鼠IgG (具Fcyl特異性； Calbiochem)再培育3丨〕分鐘。， 對於生物素結合dAb偵須j，將PE標記抗生蛋白鏈菌素 (Invitrogen)及APC標記CD20抗體（純系 2H7，BD Biosciences) 添加至管中且在室溫下培育30分鐘。 另外，為量測人類及靈長類動物血液之CD40含量，在 室溫下用與靈長類動物物種（純系5C3，BD Biosciences)交 叉反應之APC標記CD20抗體（純系2H7，BD Biosciences)及 163920.doc • 231 · 201245225 PE標記抗人類CD40抗體培育各血液樣品之等分試樣30分 鐘。 為在偵測抗體培育之後溶解紅血球且固定白血球，將 FACS溶解溶液（BD Biosciences)添加至所有管中，且在室 溫下培育樣品15分鐘。離心樣品且再懸浮於FACS溶解溶 液中，且經BD FACSCanto™藉由流式細胞測量術分析， 對CD20+ B細胞設門進行分析。對於狨猿樣品，CD20抗體 不具有交又反應性；因此對如前向及側向散射特性（尺寸） 所鑑別之所有淋巴細胞執行分析。 结果： 根據上文方法，在人類及靈長類動物血液樣品中測試聚 乙二醇化及生物素標記抗人類CD40 dAb之結合。偵測到 抗人類CD40 dAb結合至人類血液樣品中之CD20+ B細胞。 相反，在獼猴、恆河猴或黑猩猩血液樣品中之CD20+ B細 胞上或在狨猿血液樣品中之淋巴細胞上未偵測到聚乙二醇 化及生物素標記dAb之結合。BMS3h-38-2C-P40Br dAb之 結果示於圖3畫面A及晝面B中。其他dAb獲得類似結果。 使用與靈長類動物CD40交叉反應之抗人類CD40抗體確定 人類及靈長類動物物種之B細胞上CD40之可比含量。此等 資料指示來自BMS3h-56及BMS3h-38譜系之人類CD40 dAb 不能結合靈長類動物物種中之CD40。該等資料與CD40與 抗CD40 dAb之間形成複合物中Trp 109殘基之重要性一致’ 如圖1及圖2中所示β 實例10 163920.doc •232- 201245225 CD40與dAb BMS3h-56-5之間的複合物之X射線結晶學 資料收集及處理： 在人類 CD40 (SEQ ID NO: l)/BMS3h-56-5 (SEQ ID NO: 321)複合物之結構測定期間分析兩種不同晶體形式。自 CD40/BMS3h56-5複合物之晶體收集資料，驟冷且維持於 100 K，且安裝於Rigaku AFC-9測角器上。X射線源為使用 具有MicroMax™共焦光學器件及Saturn 92偵測器之銅目標 的Rigaku FR-E。在極高冗餘度下收集資料以增加硫反常 φ 繞射信號，希望使用彼信號以使資料分階段。用HKL2000 處理資料（HKL Research; Otwinowski 等人，In Mei/zoi/s Enzymol. Macromolecular Crystallography第 A部分，Caster 等人編，第 276卷，第 307·326 頁，Academic Press, Inc.， New York，NY (1997))。此晶體之資料收集統計概述於下 文及表24中： 空間群：1222 ; 單位晶胞：a=156.6 A ; b=158.3 A ; c=200.7 A ; # 鑲嵌度為0.59至0.M ;排斥觀測：1028 ; 0.06%。 表24 S09-167 解析度，A 量測值 單值 冗餘度 完成％ R值 Ι/σι 整趙 50.00-3.30 1603547 37772 42.5 99.8 0.137 33.7 第一殼層 50.00-8.94 >38193 1971 40.1 97.1 0.049 58.7 最後一殼層 3.36-3.30 >37054 1861 43.6 99.8 0.439 12.5 由驟冷至100 K且安裝於Rayonix MX-225偵測器上之晶 體在加拿大光源束線CMCF1 (Canadian Light Source beamline CMCF1) (08-ID-1)下收集第二晶形，且波長為 163920.doc •233 · 201245225 0.9793 A。此等資料藉由夏姆洛克結構（Shamrock Structures) (R. Walter 及 G. Ranieri)收集且用 HKL2000 處 理。此晶體之資料收集統計概述於下文及表25中： 空間群：C2 ; 單位晶 胞：a=199.3 A ；b= 48.7 A ; c= 138.8 A β=118.2° ； 鑲嵌度為0.62至0.71 :排斥觀測 ：70 ；0.08% 0 表25 Χ09-275 解析度，A 量測值 單值 冗餘度 完成％ R值 υσχ 整體 50.00-2.80 92545 29303 3.2 98.6 0.091 14.6 第一殼層 50.00-6.03 9265 3060 3.0 98.5 0.052 18.0 最後一殼層 2.90-2.80 8857 2882 3.1 98.0 0.421 3.4 分子置換模型： dAb之模型BMS3h-56-5係源自PDB ID 2VYR鏈E殘基1至 124，其中與CDR 31至35、50至5 7及99至111對應之連續殘 基藉由SPLIT_PDB (其與kabat編號31至35、50至56及95至 100G)對應移除，且接著穿過MUTATE且最終藉由 RENUMBER重新編號。MUTATE使非一致殘基變為最小一 致，亦即通常Ala或Gly，但例如Tyr—Phe及Phe->Tyr將產 生Phe。其不會建立任何原子，但對於Thr->Val、Val-> Thr、Cys->Ser及Ser->Cys，其將取代適當原子名稱，而不 會改變位置。RENUMBER將編號變為Kabat編號（Kabat等 人，*Segwewces ，農5版，美國健 康與人類服務部，Washington，D.C. (1991))，其為直接描 述CDR及構架殘基之抗體之標準編號系統。 使用 phenix.ensembler (University of Cambridge，UK)， I63920.doc -234- 201245225 自 PDB IDs 1JMA (繾 B)、1NCF (鏈 A)、1TNR (鏈 R)、 2HEV (鍵R)、2HEY (鍵R，T)及 2UWI (鍵 A、B)構築 CD40 模型，產生結構集合。此等分子之1^端（殘基24至78)加6個 殘基區段（殘基95至100)可與Ca原子之可接受之均方根距 離重疊，且用作CD40之N端區之模型。 分子置換方法： 使用程式PHASER (McCoy等人，·/·却p/. 40: 658-674 (2007))進行分子置換。監測轉譯功能Z分數 (translation function Z-score，TFZ)及對數似然增益增加， 判定是否存在實際溶液。8及8以上之TFZ分數一般表示溶 液。較小之TFZ分數伴隨對數似然增益之實質增加（>50)亦 為可接受之指示。 模型建立、密度改良及結晶改進方法： 用於分子圖形之模型建立手段包括COOT程式（Emsley等 人，Jcria Crystallogr Sect. D 60: 2126-2132 (2004)； Emsley等人，「Features and Development of Cooi」，dcia Cr_yiia//ogr D 66: 486-501 (2010))。使用已知密度改 良程式及計算分子之間的歐拉角（Eulerian angle)及平移的 其他程式執行使用非結晶對稱圖平均法之密度改良。使用 自動 BUSTER 進行改進（GlobalPhasing，Ltd.: Bricogne 等 人，Acta Crystallo^r. Sect. D 60: 2210-2221 (2004)； Tronrud 等人，Ογία//%;' J 43: 489-501 (1987))。 163920.doc -235- 201245225 用於域抗體之殘基編號系統遵循Kabat。以下比較 BMS3h-56-5之Kabat編號與直順序編號： -2-1 I I BMS-3h-56-5 1 J ST CDR1 Kabat 10 20 30 40 50 — 1 - 1 - 1 - 1 - I 坻序 10 20 30 40 50 1 - 1 - 1 - 1 - 1 BMS"3h_56—5 EVQLLESGGGLVQPGGSLRLSCAASGFTFRDYEMWWVRQAPGKGLERVSA CDR2 Kabat 60 70 80 90 A - 1 - 1 - | ABC 1 順序 60 70 80 90 100 虚 1 - 1 - 1 - 1 - 1 BMS-3h-56-5 INPQGTRTYYADSVMGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLP CDR3 Kabat 99101 110 116 II - 1 -1 順序 110 119 BMS-3h-56-5 » 1 FTFDDWGQGTLVTVSSAAA (SEQ ID NO: 3) 在Kabat編中，BMS3h-56-5具有插入殘基52A、82A、 82B、82C，且遺漏殘基100。在兩種編號系統中，給予作 為表現構築體之一部分的N端之Ser及Thr負編號。 測定CD40/BMS3h-56-5複合物之結構： PHASER能夠將4個BMS3h-56-5 dAb分子定位於1222晶 形中且將3個BMS3h-56-5 dAb分子定位於C2晶形中。在 1222晶形中，TFZ分數在7.6至41.0之範圍内，且對數似然 增益之增加在77至446之範圍内。用於BMS3h-56-5 dAb分 -236- 163920.doc 201245225 子之此等溶液經由1222晶體形成螺旋狀dAb分子行，其藉 由大通道與其他行分離。在C2晶形中，TFZ分數在7.7至 16.5之範圍内，且對數似然增益之增加在110至150之範圍 内。將dAb包裝於此晶形中並不重複或對稱。 使用CD40 N端結構域之集合模型，可將CD40之N端結 構域之4個分子置於1222晶形中，其中TFZ分數在5.7至8.5 之範圍内，且對數似然增益之增加在83至389之範圍内。 1222晶形中CD40之4個N端結構域在4行dAb分子之間的正 中心形成凝塊。然而’其不會觸碰BMS3h-56-5 dAb分子。 在C2晶形中置放CD40之N端結構域之3個分子，其中TFZ 分數在5.8至12.1之範圍内，且對數似然增益之增加在100 至198之範圍内。在此晶形中’ N端結構域亦不接觸 BMS3h-56-5 dAb分子。 在1222晶形中，可將來自CD40/Chi220 Fab複合物之 CD40之N端結構域及來自2UWI之N端結構域重疊於CD40 N端結構域上。將N端與特定BMS3h-56-5 dAb關聯之能力 允許使用非結晶對稱（NCS)圖平均法。NCS平均法之起始 相關係數得到非對角值為〇·71至0·81。最終非對角值為 0.88至0.92。接近於N端區之電子密度是清楚的’且可追 蹤BMS3h_56-5 dAb之 CDR3之路徑。將來自 CD40/Chi220 Fab，複合物之殘基82至94及101至121重疊於2UWI上之相應 殘基上，且接著使用COOT手動改良擬合。接著將CD40之 第二結構域（殘基82至94及101至121)之此位置變換至其他 三個N端結構域上。 163920.doc 237· 201245225 進行一個改進週期，其中自由剩餘值（R-free)由0.437降 至0.380且加工剩餘值（R-work)由0.447降至0.381，與理想 之均方根鍵及角偏差有所改良。所得電子密度圖顯示殘基 109具有與Trp—致之側鏈，且顯示CD40之C端70個殘基中 之至少一些殘基所存在之密度。 因為CD40具有小二級結構，從而證明使C端約70個殘基 與電子擬合困難，所以搜索結構生物學合作研究協蛋白質 資料庫（Research Collaboratory for Structural Bioinformatics
Protein Data Base)之適當模型以有助於引導鏈追蹤。44個 中有1 6個一致及44個中有24個匹配之前兩個採樣數為 2AW2及1JMA，其具有相同序列： 125 130 140 150 160 _ I _ I _ I . I _
CD40 CSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCE
2AW2 CSPGYRVKEACGELTGTVCEPCPFGTYIAHLNGLSKCLQCQMCD 共同序列 CSPG* VK* ** T CEGCP G * * KC C* I . I . I . I . I .1 23 30 40 50 60 66 I . . I . I . I . .1 1JMA 19 30 40 50 62 (SEQ ID NOS 1270-1271) 一致殘基以適當單一字母碼記錄於共同序列線上，且類似 殘基以星號記錄於共同序列線上。此情況與CD40之N端結 構域之殘基41至84具有相同殘基段： 41 50 60 70 80
I _ I - I _ I _ I
CD40 CQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCD
CD40 CSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCE 共同序列 C PG * T C PC F * * *CH C+ _ I _ I I 一 I 一 125 130 140 150 160 (SEQ ID NOS 1272 及 1270) 一致殘基以適當單一字母碼記錄於共同序列線上，且類 •238 · 163920.doc 201245225 似殘基以星號記錄於共同序列線上。 匹配雙硫鍵： 比較CD40之殘基41至84及125至168中之雙硫鍵 殘基41至84 殘基125至168 C41-C59 Cl25-C143 [C38]-C51 C62-C77 Cl46-C161 C83[-C103] Cl 67[-C186] 括弧中之殘基不屬於序列重複中之殘基範圍。 以1JMA/2AW2模型作為指導，使用c〇〇T程式擬合一個 CD40鏈。接著將此擬合模型重疊於其他3個CD4〇鏈中之一 者上。然而’似乎在其他兩個CD40鏈中此新穎殘基段之 位置疋向不用，且此時其不能擬合。進行一個改進週期， 其中自由剩餘值由0.393降至0.366且加工剩餘值由0.400降 至0.349 ’與理想之均方根鍵及角偏差有相當大改良。 將來自1222晶形中之一個分子的BMS3h-56-5 dAb重疊於 C2晶形中之3個dAb中之每一者上。使用彼變換矩陣定向 1222晶形之第二及c端結構域《使用c〇〇T程式重建該模 型。進行一個改進週期，其中自由剩餘值由〇 361降至 0.334且加工剩餘值由0.375降至〇 3〇6，與理想之均方根鍵 及角偏差有所改良。所得電子密度圖對置放更多（：1)4〇殘 基提供指導》進行另一改進週期，其中自由剩餘值由 0.3 02降至〇,287且加工剩餘值由0,299降至0.270，與理邦之 均方根鍵及角偏差有所改良》 163920.doc •239- 201245225 接著使用習知模型建立及改進完成結構測定。若干輪最 佳化產生具有以下統計量之最終改進：自由剩餘值 0.260，加工剩餘值0.228，均方根鍵0.010 A ’均方根角 1.4。。主鏈原子之真實空間相關係數為約0.92且側鏈原子 之真實空間相關係數為0.80。最終模型具有13個水分子° 使用來自C2晶形之C端結構域之模型作為指導’使1222 晶形中之CD40模型進一步改進。若干週期使用C00T程式 建立模型及用自動BUSTER程式改進產生以下統計量：自 由剩餘值0.323，加工剩餘值0.292 ’均方根鍵0.011 A ’均 方根角1·5。》主鏈原子之真實空間相關係數為0.91且側鏈 原子之真實空間相關係數為〇·8〇。該模型不包含水分子° CO40/BMS3h-56-5複合物之整體結構： 一個BMS3h-56-5 dAb結合至一個CD40分子。如圖1中所 示，BMS3h-56-5結合至不同於抗體Chi220之抗原決定基’ 其在N末區中結合。CD40殘基（SEQ ID NO: 1)顯示為綠 色，抗原決定基殘基除外。Chi220之CD40抗原決定基殘 基顯示為藍色；BMS3h-56-5 dAb抗原決定基殘基顯示為青 色。Chi220 Fab及BMS3h-56-5 β-股顯示為紅色，CDR殘基 顯示為洋紅色，且其他環顯示為橙色。具有硫原子之 CD40、Chi220及BMS3h-56-5分子之雙硫鍵顯示為黃色。 1222晶形含有4個結晶學獨立CD40/BMS3h-56-5複合物， 且C2晶體含有3個結晶學獨立CD40/BMS3h-56-5複合物。 CD40分子具有一定量之可撓性，且結構域以7種唯一複合 物型式不同地排列，但在所有情況下均保留相互作用之總 163920.doc -240- 201245225 體性質。 BMS3h-56-5 dAb抗原決定基殘基： BMS3h-56-5之最小CD40抗原決定基定義為含有至少一 個與BMS3h-5 6-5原子之凡得瓦爾或氫鍵接觸之原子的 CD40殘基。所有複合物中之最小抗原決定基含有以下關 於 SEQ ID NO: 1 之 CD40 殘基：Trpl09、Leul21、Hisl22、 Serl24、Serl56、Alal57、Phel58、Glul59及 Hisl62。在 一些複合物中以下其他殘基以凡得瓦爾或氫鍵接觸：
Pro85 、 Asn86 、 Leu87 、 Gly88 、 Glul06 、 Glul07 、 Glyl08、HisllO、Thrll2、Cysll9、Vall20、Glnl33、 Ilel34 、 Alal35 、 Thrl36 、 Serl55 、 Lysl60 。 最大CD40抗原決定基定義為含有藉由1.7 A探針球内埋 之原子的殘基。此等殘基包括以上所有殘基加所有複合物 中之Val 154。在一些複合物中，其他内埋殘基為：
Serll8、Argl23、Thrl41、Phel51、Aspl53、Cysl61 及
Prol63 。 具有接觸殘基之BMS3h-56-5之表面的描述示於圖2中。 顯示接觸BMS3h-56-5殘基。亦顯示内埋殘基。CD40表示 為用橙色表示非重複二級結構且用洋紅色表示抗原決定基 殘基之草圖。亦顯示為棒（呈青色之碳原子）的是Cd40殘基
Trpl09、Alall5、Leul21、Serl26 及 Hisl62，其為人類與 食蟹獮猴（長尾獼猴）之間不同之七種殘基中之五者。 八1&115及861*126位於€〇40之8]\^311-56-5結合位點之相對 側。Trpl〇9 及 Leul2]在位於 CDR-3 與 FR-2(BMS-3h-56-5 殘 163920.doc •241 _ 201245225 基Leu45及Arg47)之間的BMS-h-56-5之間隙中結合。CD40 之 Hisl62與 BMS3h-56-5 dAb之 CDR-2之 Arg56相互作用。 Trpl09之突變會顯著降低或消除BMS3h-56-5活性。 視結晶學獨立複合物而定，660至740 A2之CD40表面積 由16至21個接觸殘基（更精確地表示為46至67個接觸原子） 内埋。對於BMS3h-56-5，660至780 A2之表面積由14至17 個接觸殘基（更精確地表示為48至62個接觸原子）内埋。視 結晶學獨立複合物而定，此等接觸產生3至7個氫鍵及111 至142凡得瓦爾作用力。 實例11 鑑別CD40上之dAb結合抗原決定基 為了鑑別CD40上之dAb結合抗原決定基，針對七種在殘 基76、109或121處含有特定胺基酸殘基取代之CD40-FC融 合蛋白測試dAb結合。此等CD40-FC融合蛋白包括野生型 人類 CD40 (wt-hCD40)、野生型食蟹獼猴 CD40 (wt-cCD40) 及特定胺基酸殘基突變為來自食蟹獼猴CD40 (Ml、M2、 M4、M5)或黑猩猩CD40 (M3)之序列之相應殘基的五種突 變型人類CD40蛋白（Ml至M5)。胺基酸取代列於表26中。
野生型人類CD40細胞外域（1至193)之序列係來自 REFSEQ:寄存編號NM_001250.3。在表26所示之位置使用 野生型序列之定點突變誘發產生獼猴及突變型構築體。細 胞外域與凝血酶可裂解連接子DPGGGGGRLVPRGFGTGDP (SEQ ID NO: 1273)融合，該凝血酶可裂解連接子與人類 IgGl Fc融合。該等蛋白質表現於用TIG-pYD7-GATE 163920.doc •242- 201245225
Durocher表現載體轉染之HEK-293-6E細胞中。五天之後收 集上清液。使用蛋白質A速流層析自條件培養基純化各 CD40蛋白質。管柱用PBS (20 mM磷酸鈉、0.15 M NaCM， pH 7.2)洗滌，且接著使用80 mM乙酸鈉（pH 3)溶離至五分 之一體積之1 M Tris-HCl (pH 8)中。溶離液於PBS中流過 Superdex-200管柱。 表26
名稱 簡名 殘基76 殘基109 殘基121 野生型人類CD40Fc融合物 wt-hCD40 H W L 人類CD40 (H76R) Fc融合物 hCD40-Ml R ~~w L 人類CD40 (W109L) Fc融合物 hCD40-M2 H L L 人類CD40 (W109R) Fc融合物(黑猩猩 CD40) hCD40-M3 H R L 人類 CD40 (W109L, L121P) Fc 融合物 hCD40-M4 H L P 人類CD40 (H76R，W109L，L121P) Fc 融合物 hCD40-M5 R L P ~~~~ 野生型食蟹獼猴CD40 Fc融合物 wt-cyno- CD40 R L P 分析來自3h217、3h37、3h38及3h56譜系之代表性dAb與
表26中所列之CD40-Fc融合蛋白的結合。用Bi〇Rad ProteOn XPR36 SPR儀器執行分析。SPR表面係藉由在乙 醇胺阻.斷下使用標B乙基（二甲基胺基丙基）碳化二亞@ (EDC)/N-羥基丁二醯亞胺（NHS)化學反應，將8 μ§/ηι1抗人 類 IgG(Fc)抗體（Biacore/GE Healthcare)於 10 mM 乙酸納（ρΗ 4.5)中之混合物固定於BioRad GLC感測器晶片上來製備。 用於固定及動力學結合分析之操作緩衝液為1〇 ^ 納、130 mM氣化納、0.05%吐溫20，pH 7· 1。在此等表面 上經由Fc尾在垂直力向上捕捉濃度為20 pg/ml之CD40 Fe 163920.doc •243- 201245225 融合蛋白，且將缺乏CD40-Fc蛋白之參比表面用於參比減 去。藉由在25°C下，使用240秒締合時間及420秒解離時 間，以30 μΐ/min 之流速使 405、135、45、15 及 5 nM dAb 分 析物水平方向流經捕捉之CD40-FC表面來執行動力學實 驗。該等表面用30秒脈衝之3 M MgCh，隨後用操作緩衝 液以60 μΐ/min流過在水平與垂直方向再生。雙重參比感測 器圖譜資料’且接著使用BioRad ProteOn Manager V. 2.1.0.3 8軟體擬合成1:1朗谬爾模型，以測定締合速率常 數（ka)、解離速率常數（kd)及平衡解離常數（Kd)。 發現3h-37、3h-3 8及3h-56譜系之所有dAb以高親和力 ，（KD<10·8 M)結合至含有人類CD40殘基wl〇9& Lm之 CD40-Fc融合蛋白，但與具有來自食蟹獼猴cd4〇 (L109、 P121)或黑猩猩CD40 (R109)之相應殘基之CD40-Fc融合蛋
白的結合顯著降低或不可偵測到。此情況指示來自3h37、 3h38及3h56-譜系各者之dAb特異性結合至包括人類CD4〇 之殘基109及121之抗原決定基。相反，3h_217譜系之所有 測試成員以類似親和力結合至所有所測試CD4〇 Fc融合蛋 白，指示3h-217譜系之成員結合至不包括殘基％、1〇9或 121之CD40上之位點。因此，3h_217譜系結合至與3h37、 3h-38及3h-56譜系不同之抗原決定基。表27概示使用spR 用ProteOn XPR36儀器針對dAb結合至CD40-Fc融合蛋白所 測疋之KD值。表27中之「X」意謂沒有任何證據表明在此 等條件下存在結合。 163920.doc -244- 201245225 表27
wt-hCD40 hCD40- M1 (H76R) hCD40- M2 (W109L) hCD40- M3 (W109R) hCD40- M4 (W109L ' L121P) hCD40-M5 (H76R、 W109L、 L121P) 獼猴 CD40 3h-217-5 0.47 ' 0.48 0.94 0.99 0.72 0.93 1.0 0.9 3h-217-16 0.22、 0.26 0.35 0.41 0.27 0.35 0.5 0.4 3h-217-23 0.78 ' 1.5 1.6 2.0 1.2 1.6 2.2 1.9 3h-37-2 2.0、2.0 2.6 >1000 X X X X 3h-37-ll 1.9'2.3 2.4 >1000 X X X X 3h-38-2 5.1 ' 8.0 7.2 X X X X X 3h-38-211 3.3 ' 6.1 4.0 >1000 X X X X 3h-38-215 2.1 ' 6.0 3.0 >1000 X X X X 3h-38-217 2.3 ' 2.4 3.4 >1000 X X X X 3h-56-l 3.0 ' 5.4 4.2 29 >1000 X X X 3h-56-2 3.8 ' 3.2 6.1 44 >1000 X X X 3h-56-5 5.3 ' 4.7 7.2 65 >1000 X X X 3h-56-202 2.3 ' 1.3 3.3 160 X X X ~ X 3h-56-206 0.60、1.4 1.0 55 X X X X 3h-56-217 1.0 ' 1.9 1.4 2.5 23 X X X 表28顯示使用SPR用ProteOn XPR36儀器針對dAb結合至 CD40-FC融合蛋白所測定之締合速率常數（ka)、解離速率常 數（kd)及平衡解離常數（KD)。表28中之「X」意謂沒有任何
證據表明在此等條件下存在結合。 表28 配位體 dAb Ka (1/Ms) kd (1/s) Kd (nM) wt-hCD40 3h-217-5 2.71xl06 1.27x10° 0.47 wt-hCD40 (重複） 3h-217-5 2.03xl06 9.81X10-4 0.48 hCD40 Ml (H76R) 3h-217-5 3.17xl06 2.99x10° 0.94 hCD40 M2 (W109L) 3h-217-5 2.55x10° 2.51x10·" 0.99 hCD40 M3 (W109R) 3h-217-5 2.73x10° 1.96x10° 0.72 hCD40 M4(W109L> L121P) 3h-217-5 2.78xl06 2.59x1 0.93 hCD40-M5 (H76R、W109L、 L121P) 3h-217-5 2.44x106 2.42x1 O'3 0.99 wt-cCD40 3h-217-5 2.46x106 2.12x10° 0.86 163920.doc -245 - 201245225 wt-hCD40 3h-217-16 4.47x10。 9.91X10*4 0.22 wt-hCD40 (重複） 3h-217-16 3.3〇xl06 8.47X10·4 0.26 hCD40 Ml (H76R) 3h-217-16 4.83xl06 1.68xl〇-J 0.35 hCD40 M2 (W109L) 3h-217-16 4.06xl0b 1.67x1 O'3 0.41 hCD40 M3 (W109R) 3h-217-16 3.78xl06 1.04xl0'J 0.27 hCD40M4(W109L、L121P) 3h-217-16 4.39xl06 1.52xl0*3 0.35 hCD40-M5 (H76R、W109L、 L121P) 3h-217-16 3.65xl06 1.70x10-3 0.47 wt-cCD40 3h-217-16 3.44xlOG 1.47x10° 0.43 wt-hCD40 3h-217-23 1.64x10。 1.27x10° 0.78 wt-hCD40 (重複） 3h-217-23 1.07χ106 1.63x1 O'3 1.52 hCD40 Ml (H76R) 3h-217-23 1.64xlOb 2.62xlO'J 1.59 hCD40 M2 (W109L) 3h-217-23 1.49xl0& 2.91><10'J 1.95 hCD40 M3 (W109R) 3h-217-23 1.53x10。 1.86x10」 1.22 hCD40 M4 (W109L、L121P) 3h-217-23 1.67xl06 2.68x10·3 1.61 hCD40-M5 (H76R、W109L、 L121P) 3h-217-23 1.3〇xl06 2.87x1 O'3 2.21 wt-cCD40 3h-217-23 1.24x10。 2.35xlO'J 1.90 wt-hCD40 3h-37-2 2.12x10s 4.17XHT 1.96 wt-hCD40 (重複） 3h-37-2 2.13xl05 4.26x1 O'4 2.00 hCD40 Ml (H76R) 3h-37-2 2.17x10s 5.62X10·4 2.58 hCD40 M2 (W109L) 3h-37-2 >1000 hCD40 M3 (W109R) 3h-37-2 X hCD40 M4 (W109L、L121P) 3h-37-2 X hCD40-M5 (H76R、W109L、 L121P) 3h-37-2 X wt-cCD40 3h-37-2 X wt-hCD40 3h-37-ll 2.91xl05 5.60X10·4 1.92 wt-hCD40 (重複） 3h-37-ll 2.81x10s 6.40x10"* 2.28 hCD40 Ml (H76R) 3h-37-ll 3.00x10' 7.17X10·4 2.39 hCD40 M2 (W109L) 3h-37-ll >iooo hCD40 M3 (W109R) 3h-37-ll X hCD40 M4 (W109L、L121P) 3h-37-ll X hCD40-M5 (H76R、W109L、 L121P) 3h-37-ll X wt-cCD40 3h-37-ll X wt-hCD40 3h-38-2 1.20x10s ό.ΟδχΙΟ*4 5.07 wt-hCD40 (重複） 3h-38-2 1.42xl05 1.14x10° 8.04 hCD40 Ml (H76R) 3h-38-2 1_4〇χ105 1.00x10° 7.15 hCD40 M2 (W109L) 3h-38-2 X hCD40 M3 (W109R) 3h-38-2 X hCD40M4(W109L、L121P) 3h-38-2 X hCD40-M5 (H76R、W109L、 L121P) 3h-38-2 X wt-cCD40 3h-38-2 X wt-hCD40 3h-38-211 1.11x10s 3.62X10·4 3.26 wt-hCD40 (重複） 3h-38-211 1.2〇xl05 7.28x10"* 6.08 hCD40 Ml (H76R) 3h-38-211 1.28X103 5-lOxlO·4 3.98 163920.doc •246- 201245225
hCD40 M2 (W109L) 3h-38-211 >1000 hCD40 M3 (W109R) 3h-38-211 X hCD40 M4 (W109L > L121P) 3h-38-211 X hCD40-M5 (H76R、W109L、 L121P) 3h-38-211 X wt-cCD40 3h-38-211 X wt-hCD40 3h-38-215 1.37xl05 2.88X10·4 2.10 wt-hCD40 (重複） 3h-38-215 1.36x10s 8.20X10·4 6.02 hCD40 Ml (H76R) 3h-38-215 1.75X103 5.30X10·4 3.03 hCD40 M2 (W109L) 3h-38-215 >1000 hCD40 M3 (W109R) 3h-38-215 X hCD40M4(W109L ' L121P) 3h-38-215 X hCD40-M5 (H76R、W109L、 L121P) 3h-38-215 X wt-cCD40 3h-38-215 X wt-hCD40 3h-38-217 1.27x10" 2.96X10·4 2.34 wt-hCD40 (重複） 3h-38-217 1.44xl05 3.40X10·4 2.37 hCD40 Ml (H76R) 3h-38-217 1.41xl05 4.81X10*4 3.41 hCD40 M2 (W109L) 3h-38-217 >1000 hCD40 M3 (W109R) 3h-38-217 X hCD40 M4 (W109L、L121P) 3h-38-217 X hCD40-M5 (H76R、W109L、 L121P) 3h-38-217 X wt-cCD40 3h-38-217 X wt-hCD40 3h-56-l 2.52x10s 7.50X10·4 2.97 wt-hCD40 (重複） 3h-56-l 1.93x10s 1.03X10'3 5.35 hCD40 Ml (H76R) 3h-56-l 2.31xl05 9.67X10·4 4.18 hCD40 M2 (W109L) 3h-56-l 1.92x10' 5.57xl〇-J 29.10 hCD40 M3 (W109R) 3h-56-l >1000 hCD40 M4 (W109L ' L121P) 3h-56-l X hCD40-M5 (H76R、W109L、 L121P) 3h-56-l X wt-cCD40 3h-56-l X wt-hCD40 3h-56-2 2.46xlOi 9.27x1 O'4 3.77 wt-hCD40 (重複） 3h-56-2 1.97x10s 6.24 xHT4 3.17 hCD40 Ml (H76R) 3h-56-2 2.20x10' 1.33xlO_J 6.05 hCD40 M2 (W109L) 3h-56-2 1.89^103 8.3〇xlO'j 43.90 hCD40 M3 (W109R) 3h-56-2 >1000 hCD40 M4 (W109L ' L121P) 3h-56-2 X hCD40-M5 (H76R、W109L、 L121P) 3h-56-2 X wt-cCD40 3h-56-2 X wt-hCD40 3h-56-5 1.78xl05 9.38X10·4 5.26 wt-hCD40 (重複） 3h-56-5 1.53x10s 7.19X10·4 4.69 hCD40 Ml (H76R) 3h-56-5 1.69405 1.21x10° 7.18 hCD40 M2 (W109L) 3h-56-5 1.38xl05 8.89xlO'J 64.60 hCD40 M3 (W109R) 3h-56-5 >1000 hCD40 M4 (W109L ' L121P) 3h-56-5 X 163920.doc -247- 201245225
hCD40-M5 (H76R、W109L、 L121P) 3h-56-5 X wt-cCD40 3h-56-5 X wt-hCD40 3h-56-202 1.82E+05 4.15xl(T 2.27 wt-hCD40 (重複） 3h-56-202 1.77E+05 2.21X10·4 1.25 hCD40 Ml (H76R) 3h-56-202 1.76E+05 5.79X10-4 3.29 hCD40 M2 (W109L) 3h-56-202 1.35E+05 2.00x10“ 155.00 hCD40 M3 (W109R) 3h-56-202 X hCD40M4(W109L、L121P) 3h-56-202 X hCD40-M5 (H76R、W109L、 L121P) 3h-56-202 X wt-cCD40 3h-56-202 X wt-hCD40 3h-56-206 6.48E+05 3.89xl(T 0.60 wt-hCD40 (重複） 3h-56-206 3.27E+05 4.72X10·4 1.44 hCD40 Ml (H76R) 3h-56-206 5.65E+05 5.45x1 O'4 0.96 hCD40 M2 (W109L) 3h-56-206 3.38E+05 2.00x10·' 54.70 hCD40 M3 (W109R) 3h-56-206 X hCD40M4(W109L、L121P) 3h-56-206 X hCD40-M5 (H76R、W109L、 L121P) 3h-56-206 X wt-cCD40 3h-56-206 X wt-hCD40 3h-56-217 4.71E+05 4.70X10·4 • 1.00 wt-hCD40 (重複） 3h-56-217 2.91E+05 5.46X10·4 1.87 hCD40 Ml (H76R) 3h-56-217 4.45E+05 6.35X10"4 1.43 hCD40 M2 (W109L) 3h-56-217 4.25E+05 1.05xl0'J 2.48 hCD40 M3 (W109R) 3h-56-217 2.91 E+05 6.70xl0o 23.00 hCD40 M4 (W109L ' L121P) 3h-56-217 X hCD40-M5 (H76R、W109L、 L121P) 3h-56-217 X wt-cCD40 3h-56-217 X 實例12 構築Fc融合多肽 如本文所揭示，可構築各種組態之包含dAb之抗體多 肽。在此實例中，各種dAb與Fc域融合產生抗人類CD40可 變域構築體之Fc融合多肽，諸如3h37-202、3h37-235、 3h37-258及3h37-202 ° 在一個代表性實例中，dAb BMS3h-56-269 (SEQ ID NO: 417)與經修飾之 IgGl (IgGl*) Fc 域（SEQ ID NO: 1284)融 合。在dAb-IgGl* Fc域融合多肽中，dAb BMS3h-56-269之 163920.doc -248- 201245225 C端融合至具有序列Ala-Ser-Thr之連接子三肽，其又與
IgGl*Fc域（SEQ ID NO: 1284)融合。IgGl *Fc域含有修飾 C5S，係指SEQ ID NO: 1284中之位置編號》IgGl Fc域之 C5通常與IgG分子之輕鏈中之Cys殘基形成雙硫鍵。
IgGl*Fc域亦含有C11S及C14S突變以消除IgGl鉸鏈區中之 鏈間雙硫鍵。最終，IgGl*Fc域含有P23S突變以降低Fc域 效應功能。dAb-IgGl*Fc融合多肽具有以下序列，其中
Ala-Ser-Thr連接子呈粗體且Fc域之修飾呈粗斜體：
• 1 EVQLLESGGG LVQPGGSLRL SCAASGFTFR DYEMWWVRQA PGKGLERVSA 51 INPQGTRTYY ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKLP 101 FRFSDRGQGT LVTVS3ASTE PKSSDKTHTS PPSPAPELLG GSSVFLFPPK 151 PKDTLMISRT PEVTCVWDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY 201 NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP .251 QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP 301 VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG 351 K (SEQ ID NO: 1286) SEQ ID NO: 1286中所示之dAb-IgGl*Fc融合多肽為計算 分子量為39,127 Da之單體。其可形成計算分子量為78,254 Da之二聚體》 或者，dAb BMS3h-56-269 (SEQ ID NO: 417)與人類 IgG4 Φ Fc域（SEQ ID NO: 1285)融合。dAb BMS3h-56-269之C端又 融合至Ala-Ser-Thr連接子，該Ala-Ser-Thr連接子與IgG4 Fc 域（SEQ ID NO: 1285)融合》IgG4 Fc域含有修飾S10P，係 指 SEQ ID NO: 1285 中之位置編號。BMS3h-56-269-IgG4 Fc 融合多肽具有以下序列，其中Ala-Ser-Thr連接子呈粗體且 S10P修飾呈粗斜體： 163920.doc -249- 201245225 1 EVQLLESGGG LVQPGGSLRL SCAASGFTFR DYEMWWVRQA PGKGLERVSA 51 INPQGTRTYY ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKLP 101 FRFSDRGQGT LVTVSSASTE SKYGPPCPPC PAPEFLGGPS VFLFPPKPKD 151 TLMISRTPEV TCWVDVSQE DPEVQFNWYV DGVEVHNAKT KPREEQFNST 201 YRVVSVLTVL HQDWLNGKEY KCKVSNKGLP SSIEKTISKA KGQPREPQVY 251 TLPPSQEEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD 301 SDGSFFLYSR LTVDKSRWQE GNVFSCSVMH EALHNHYTQK SLSLSLGK (SEQ ID NO: 1287) SEQ ID NO: 1287中所示之BMS3h-56-269-IgG4 Fc融合多 肽為計算分子量為38,867 Da之單體》其可形成計算分子量 為77,734 Da之二聚體。 下文比對 BMS3h-56-269 (SEQ ID NO: 417)、BMS3h-56-269-IgGl*Fc 融合多肽（SEQ ID NO: 1286)及 BMS3h-56-269· IgG4 Fc融合多肽（SEQ ID NO: 1287)之序列，其中Fc域之 起始用箭頭標出： BMS3h56-269 (SEQ ID ΝΟ:4Π) (1) BMS3h56-269-CTL2 (SEQ ID NO:1286) (1) BMS3h56-269-Ig4 (SEQ ID NO:1287) (1) BMS3h56-269 (SEQ ID NOMl?) (34) BMS3h56-269-CTL2 (SEQ ID NO:1286) (51) BMS3h56-269-Ig4 (SEQ ID NO:1287) (51) (84) BMS3h56-269 {SEQ ID NO:417) 麵難鱗鍾纖 BMS3h56-269-CTL2 (SEQ ID NO:1286) (101) AST|pgSSDKTHTS_S^^L®S® 藤 BMS3h56-269-Ig4 (SEQ ID NO:1287) <101) ast|s|yg---PPCgc^^Ef
Fc之起始 163920.doc -250- 201245225 BMS3h56-269 (SEQ ID NO:417) (117) BMS3h56-269-CTL2 (SEQ ID NO:1286) (151)
BMS3h56-269-Ig4 (SEQ ID NO:1287) (148)
Y
BMS3h56-269 (SEQ ID NO:417) (117) BMS3h56-269-CTL2 (SEQ ID NO:1286) (201)
(SEQ ID NO:1287) (198) 醒 獅醺 BMS3h56-269-Ig4
BMS3h56-269 (SEQ ID NO:417) (117)
BMS3h56-269-CTL2 (SEQ ID NO:1286) (251)
BMS3h56-269-Ig4 (SEQ ID ΝΟ.Ί287) (248) BMS3h56-269 (SEQ ID NO:417) (117) BMS3h56-269-CTL2 《SEQ ID NO:1286> (301) BMS3h56-269-Ig4 (SEQ ID NO:1287) (298) BMS3h56-269 (SEQ ID NO:417) (117}- BMS3h56-269-CTL2 (SEQ ID NO:1286) (351) | BMS3h56-269-Ig4 (SEQ ID NO:1287) (348)麗
使用實例1 1中所揭示之細胞培養方法表現Fc融合多肽。 管柱用 PBS (20 mM磷酸鈉、0.15 M NaCl，pH 7.2)洗滌， 且接著使用80 mM乙酸鈉（pH 3)溶離至五分之一體積之1 Μ Tris-HCl (pH 8)中。溶離液於PBS 中流過Superdex-200管 柱0 實例13 CD40 Fc融合多肽活性分析 功能上分析抗人類CD40 Fc融合多肽拮抗CD40活性之能 力。所測試之CD40活性為藉由hCD40L驅動之初級人類單 核細胞源性樹突狀細胞（DC)活化發生之B細胞增殖及細胞 -251 - 163920.doc 201245225 激素產生。使用實例6中所揭示之分析量測B細胞增殖及細 胞激素產生。除非另外說明，否則所有分析均在補充有 10%胎牛血清（FCS)之RPMI培養基中執行。dAb-Fc域融合 多肽展示CD40依賴性活化之有效抑制作用（亦即拮抗作 用）。注意到在任何人類CD40特異性dAb-Fc域融合多肽中 無促效特性。使用各種分析得到之結果示於表29中。使用 實例11中所揭示之分析來分析3h56-269-IgG4與固定之人類 CD40之結合。對於 3h56-269-IgG4，在30 pM、25°C下及在 40 pM、37°C下量測結合固定之人類-CD40的表觀親合力影 響之Kd值。 表29 dAb-Fc MZCD40L 驅動之人類 B細胞增殖 EC5〇 (nM) CHO-hCD40L 驅動之人 類B細胞 增殖 EC50 (nM) T-B細胞 MLR EC50 (nM) CHO- hCD40L 驅動之 DC活化 TNF EC5〇 (nM) CHO-hCD40L 驅動之 DC活化 IL-6 EC50 (nM) CHO-hCD40L 驅動之DC 活化 IL-12 EC50 (nM) 3h37- 202- IgG4 0.16 ±0.08 5.0 、 3.0 5.0'6.0 0.53 ±0.1 3h37- 202- IgGl* 0.27'0.22 3.0 ' 7.0 0.74 ± 0.2 3h38- 235- IgG4 0.20、0.15 6.0 ' 10.0 16.7 ±5.7 0.67 ± 0.3 3h38- 235- IgGl* 0.25 ±0.1 4.0 士 1.0 0.88 ± 0.3 3h56- 258- IgG4 0.16 ±0.05 1.0 ±0.8 2.4 ± 0.99 0.22 士 0.08 0.11 ± 0.05 0.3 ± 0.2 163920.doc -252- 201245225 3h56- 258- IgGl* 0-063 ± 0.03 0.6 ±0.4 2.0 土 0.63 0.31 ±0.1 3h56- 269- IgG4 0.028 ±〇.〇l 0.27 士 0.08 0.52 ± 0.07 0·16± 0.03 0.09 ± 0.02 0.092 ± 0.03 3h56- 269- IgGl* 0025 ± o.oi 0.25 士 0.04 0.53 ±0.1 0·27 士 0.06 0.15 士 0.05 0·14±0_06 儘管已根據上文實例詳細描述了本發明實施例’但應瞭 解在不背離此等實施例之精神的情況下可作出各種修改， 且將易於為習此相關技藝之人士所知。 【圖式簡單説明】 圖1展示人類CD40(SEQ ID NO: 1)之兩種不同共晶體結 構之結合模式，一者具有dAb BMS3h-56-5 (SEQ ID NO: 321)及一者具有 Chi220 抗體之 Fab，。BMS3h-56-5 及 Chi 220 Fab·分子顯示為包含β-股（在dAb中以箭頭表示）及非重複二 級結構（在dAb中以環表示）之草圖。亦顯示互補決定區 (CDR)，CD40亦顯示為包含人類CD40之BMS3h-56-5抗原 決定基殘基之草圖。亦顯示Chi220抗原決定基殘基。亦顯 示雙硫鍵。標記CD40之N端（N)及C端（C)。 圖 2展示接觸人類 CD40 (SEQ ID NO: 1)之 BMS3h-56-5 (SEQ ID NO: 321)之空間填充模型，其以草圖顯示。顯示 接觸CD40之dAb BM:53h-56-5之表面殘基。標記BMS3h-56-5 CDR3 區及 FR-2 殘基 Leu45、Arg47、Arg56 及 Phe99。在 此圖中使用Kabat編號(Kabat等人，〇//所 /«ieresi，第5版，美國健康與人類服務部（U.S. Dept. Health & Human Services)，Washington，D.C. (1991))，且 163920.doc • 253· 201245225 與順序編號之不同之處在於使用插入殘基來保持β-股之殘 基編號相同。因此，對於BMS3h-56-5，順序殘基53變為殘 基52A，順序殘基84、85及86分別變為82A、82B、82C， 且Kabat殘基編號100缺失（其將介於順序殘基103與104之 間）；CD40亦以包含非重複二級結構及BMS3h-56-5抗原決 定基之草圖表示。在人類與長尾獼狼（Macaca /ascicw/arb) (食蟹獼猴（cynomolgus monkey))之間不同的CD40殘基 Alall5、Phe99、Serl26、Hisl62、Leul21及 Trpl09以棒圖 示法顯示。作為BMS3h-56-5抗原決定基之一部分的在人類 φ 與食蟹獼猴之間不同的CD40殘基為Trpl09、Leul21及 Hisl62。CD40 殘基 Trpl09 及 Leul21 處於 BMS3h-56-5 CDR3 與FR-2之間的間隙中。Trpl09之突變大大降低或消除 BMS3h-56-5活性。 圖3展示來自人類及靈長類動物物種之血液樣品上聚乙 二醇化抗人類CD40 dAb BMS3h38-2C-P40Br之結合。圖3A 顯示BMS3h38-2C-P40Br結合至人類及獼猴B細胞；圖3B顯 示BMS3h3 8-2C-P40Br結合至人類、恆河猴及黑猩猩B細 · 胞。 圖4、圖5、圖6及圖7顯示分別來自譜系BMS3h-56、 BMS3h-3 7、BMS3h-3 8及BMS3h-198之代表性域抗體多肽 之 ClustalW2 比對。 163920.doc -254- 201245225 序列表 <11〇>美商必治妥美雅史谷比公司 <120拮抗CD40之抗趙多肽 <130 200896-0004-00-WO (481834) <140> 101114258 <141> 2012-04-20 <150 61/477,904 <151> 2011-04-21 <160> 1287 <170> Patcntln version 3.5 <210> 1 <211> 277 <212> PRT <213>智人 <400> 1
Met Val Arg Leu Pro Leu Gin Cys Val Leu Trp Gly Cys Leu Leu Thr 15 10 15
Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gin Tyr Leu 20 25 30 lie Asn Ser Gin Cys Cys Ser Leu Cys 31n Pro Gly Gin Lys Leu Val 35 40 45
Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 50 55 60
Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gin His 65 70 75 80
Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gin Gin Lys Gly Thr 85 90 95
Ser Glu Thr Asp Thr lie Cys Thr Cys Glu Glu Gly Trp His Cys Thr 100 105 ilO
Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 115 120 125
Phe Gly Val Lys Gin lie Ala Thr Gly Val Ser Asp Thr He Cys Glu 130 135 140
Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 145 150 155 160
Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gin Gin 165 170 175
Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gin Asp Arg Leu 180 185 190
Arg Ala Leu Val Val lie Pro lie lie Phe Gly lie Leu Phe Ala lie 195 200 205 163920-序列表.doc 201245225
Leu Leu Val Leu Val Phe He Lys Lys Val Ala Lys Lys Pro Thr Asn 210 215 220
Lys Ala Pro His Pro Lys Gin Glu Pro Gin Glu He Asn Phe Pro Asp 225 230 235 240
Asp Leu Pro G)y Ser Asn Thr Ala Ala Pro Val Gin Glu Thr Leu His 245 250 255
Gly Cys Gin Pro Val Thr Gin Glu Asp Gly Lys Glu Ser Arg lie Ser 260 265 270
Val Gin Glu Arg Gin 275 <210> 2 <211> 278 <212> PKT <213>長尾獼猴 <400> 2
Met Val Arg Leu Pro Leu Gin Cys Val Leu Trp Gly Cys Leu Leu Thr 15 10 35
Ala Val Tyr Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gin Tyr Leu 20 25 30
He Asn Scr Gin Cys Cys Ser Leu Cys Glu Pro Gly Gin Lys Leu Val 35 40 45
Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 50 55 60
Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Tbr Arg Cys His Gin His 65 70 75 80
Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Va】G】n Gin Lys Gly Thr 85 90 95
Ser Glu Thr Asp Thr lie Cys Thr Cys Glu Glu Gly Leu His Cys Thr 100 105 110
Ser Glu Ser Cys Glu Ser Cys Val Pro His Arg Ser Cys Leu Pro Gly 115 120 125
Phe Gly Val Lys Gin lie Ala Thr Gly Val Ser Asp Thr He Cys Glu 130 135 140
Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 145 150 155 160
Cys Arg Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Va】Val Gin Gin 165 170 175
Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gin Asp Arg Gin ]80 185 190
Arg Ala Leu Val Val lie Pro He Cys Leu Gly lie Leu Phe Val lie -2-
163920-序列表.doc 201245225
Arg Ala Leu Val Val lie Pro He Cys Leu Gly He Leu Phe Val lie 195 200 205
Leu Leu Leu Val Leu Val Phe lie Lys Lys Val Ala Lys Lys Pro Asn 210 215 220
Asp Lys Val Pro His Pro Lys Gin Glu Pro Gin Glu He Asn Phe Pro 225 230 235 240
Asp Asp Leu Pro Gly Ser Asn Pro Ala Ua Pro Val Gin Glu Thr Leu 245 250 255
His Gly Cys Gin Pro Val Thr Gin Glu Ksp Gly Lys Glu Set Arg lie 260 265 270
Ser Val Gin Glu Arg Gin 275
<210> 3 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 3
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 沁 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 】10
Thr Val Ser Ser Ala Ala Ala 115 <210> 4 <211> 25 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 163920-序列表.doc 201245225 <220> <221> misc_feature <222> (1).7(25) <223>此序列可涵蓋1至5個「Gly Gly Gly Gly Ser」重複單元 <400> 4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Set Gly 15 10 15
Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 <210> 5 <211> 3 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <400> 5 Ala Ser Thr 1
<210> 6 <211> 6 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <400> 6
Thr Val Ala Ala Pro Ser <210> 7 <211> 3 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽
<400> 7 Thr Val Ala 1 <210> 8 <211> 7 <212> PRT <213>人工序列 <220> <223>人工序列之描述··合成肽 <400> 8
Ala Ser Thr Ser Gly Pro Ser <210> 9 <211> 116 163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 9
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Giu Met 丁rp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr An: Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asi> Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Scr Leu Arg Ala Gli. Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gin Gli. Trp Gly Gin Gly Thr Leu Val 100 10f 110
Thr Val Ser Ser 115 <210> 10 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 10
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Ar^： Tlir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 163920-序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 11 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> II
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 135 <210> 12 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 12
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Va】Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -6-
163920-序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly G)n Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 13 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 13
Glu Val Gin Leu Leu Glu Ser Gly Gly jly Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu Scr Cys Ala Ala Ser 31y Phe Thr Phe Thr Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser SeT Tie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 14 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 14
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30 163920-序列表.doc 201245225
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala GJu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Ala Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> 15 <211> Π6 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 15
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe lie Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 16 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 163920·序列表.doc 201245225 <400> 16
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30
His Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Met lie Asp Ala Asp Gly Leu Gly Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ksp Thr Ala Val Tyr Tyr Cys 85 .90 95
Ala Lys Pro Gly Pro Gin Phe Gly Gin Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 17 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 17
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30
Asp Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr He Ser Ala Scr Gly Val Phe Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu \sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Pro Asn Arg Phe Ala Leu \sn Asn Phe Asp Tyr Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 163920-序列表.doc 201245225 <210> 18 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 18
Asp lie Gin Met Thr Gin Ser Pro Scr Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser He Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Giy Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Gly Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 19 <211> 108 <212〉 PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 19
Asp He G3n Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Scr Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Ala Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 -10·
163920·序列表.doc 201245225 <210> 20 <2Π> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 20
Glu Val Gin Leu Leu Glu Ser Gly Gly 31y Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 30 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 21 <211> 120 <212> PRT <213>人工序列 <22Q> <223>人工序列之描述：合成多肽 <400> 21
Glu Val Gin Leu Leu Glu Ser Gly Gly 31y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser 31y Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Val Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Trp Val 35 40 45
Scr Ser lie Ser Ala Ser Gly Gly Scr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys -11 - 163920-序列表.doc 201245225 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 22 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 22
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 23 <2】1> 1]9 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 23
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Sei Cys Ala Ala Ser Gly Phe Thr Phe Pro Lys Asn 20 25 30
Glu Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Glu Ser Asp Gly Gin Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -12- 163920-序列表.doc 201245225
Lys Gly Arg Phc Thr lie Ser Arg Asp Asn Set Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Aig Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asn Arg lie Pro Asp Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Ήιγ Val Ser Ser 115 <210> 24 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 24
Glu Val Gin Leu Leu Glu Ser Gly Gly jly Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu SeT Cys Ala Ala Ser jly Phe Thr Phe Asp Ala Gly 20 25 30
Ala Met Thr Trp Val Arg Gin Ala Pro jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Lys Glu Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Va) Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Gly Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 25 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 25
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe frhr Phe Gly Asp Ala 20 25 30 13- 163920-序列表.doc 201245225
Ala Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Gin Pro Met Gly Asp Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro TTir Leu Gin Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 26 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 26
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Ser 20 25 30
Pro Met Ήιγ Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Thr Ser Asn Gly Tyr Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Thr Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 27 <211> Π9 <212> PRT <2Π>人工序列 <220> <223>人工序列之描述：合成多肽 -14-
163920-序列表.doc 201245225 <400> 27
Glu Val Gin Leu \^u Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phc Asp Glu His 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Gly Pro Asp Gly Phe His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg A]a Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg He Pro Thr Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 28 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 28
Glu Val Gin Leu Leu Glu Ser Glv Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Tyr 20 25 30
His Met Ser Trp. Val Arg Gb Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Thr Pro Leu Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Giu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Ser Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 163920-序列表.doc •15·
S 201245225 <210> 29 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 29
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ήιγ Asn 20 25 30
Ala Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 丁rp Val 35 40 45
Ser Arg lie Ser Pro Gly Gly Asp Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg Val Pro Asp Leu Leu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 30 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 30
Glu Val Gin l-eu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Ser Glu 20 25 30
Giu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Ser Ala Asp Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 -16·
163920·序列表.doc 201245225
Ala Lys Gly Arg Val Pro Asp Leu Leu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 31 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 33
Glu Val Gin Leu Leu Glu Ser Gly Gly (ily Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Asp 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Cily Lys Gly Leu Glu Trp Val
Ser Arg lie Ala Val Asp Gly Asp Arg r’hr 丁yr Tyr AU Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr 31e Ser Arg Asp asn Ser Lys Asn Thr Uu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 i)〇 95
Ala Lys Gly Lys Val Pro Ser Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115
<210> 32 <2U> 119 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 32
Glu Val Gin Leu Leu Glu Ser Gly Gly ijly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Met 20 25 30
Asp Met Scr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Thr Gly Asp Gly Met Asn Rir Tyr Tyr Ala Asp Ser Val •17- 163920-序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 33 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 33
Glu Val Gin Leu Leu GIu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Asp 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asn Ala Gly Gly Val His Ώιγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <21Q> 34 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 34
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15 -18· 163920·序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Phe Thr Phe Asp Asp Asp 20 25 30
Ser Met Thr Trp VaJ Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Ser Ser Asp Gly Ala Scr Hir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr IU Ser Arg Asp 八sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 !ϊ〇 95
Ala Lys Gly Val Thr Pro Asp Leu Ήιγ Phe Asp Tyr Trp Gly Gin Gly m 105 110
Thr Leu Val Thr Val Ser Ser 115
<210> 35 <211> 119 <212〉 PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 35
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Scr (jly Phe Thr Phe Thr Glu Glu 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Ser Val Gly Glu Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu \sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Vat Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <220> 36 <211> 119 <212> PRT <213>人工序列 -19- 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 36
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Va[ Gin Pro Gly Giy 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Set 20 25 30
Ala Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Asp Asn Pro Gly Gin His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 37 <21]> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 37
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gin His 20 25 30
Ser Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Gly Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Glu Val Pro Arg Leu His Phe Asp Tyr Trp Gly Gin Gly loo 105 no -20-
163920-序列表.doc 201245225
Thr Leu Val Thr Val Ser Ser 115 <210> 38 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 38
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gin Glu 20 25 30
Pro Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Ala Tyr Asn Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly He Thr Pro Asn Leu ThT Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 39 <211> 119 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 39
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asn Tyr 20 25 30
Pro Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asn Ala Thr Gly Ser lie Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -21 · 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Val lie Pro His Leu Met Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Scr Ser 115 <210> 40 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 40
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Thr Gly Thr Gly Asn Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Gin Gly Val Val Pro Tyr.Leu Ala Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 41 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 41
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Va) Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Asp 20 25 30
Ala Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -22-
163920·序列表.doc 201245225
Ser Arg lie Asn Val Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va) Tyr Tyr Cys 85 ?0 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <2]〇> 42 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 42
Glu Val Gin Leu Leu Glu Ser Gly Giy *jly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser '31 y Phe Thr Phe Asp Arg Ala 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro '31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Ser Gly Glu Gly Lys Cys Thx Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Met Val Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 43 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 43
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly •23- 163920·序列表.doc 201245225 】 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Trp Glu 20 25 30
Pro Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asn Ser Ser Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Aia Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Met Val Pro Asn Leu Val Fhe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 44 <2H> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 44
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Glu 20 25 30
Pro Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Pro Pro Glu Gly Ala Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly lie Thr Pro Asn Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 45 <21.1> 119 24-
163920·序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 45
Glu Val Gin Leu Leu GIu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asa His 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Ser Arg Gly Gly Leu Gin Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asa Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly lie Val Pro Asp Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thx Leu Val Thr Val Ser Ser 115 <210> 46 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 46
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr 20 25 30
Pro Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asn Gly Asp Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly He lie Pro Ala Met Gin Phe Asp Tyr Trp Gly Gin Gly -25· 163920-序列表.doc 201245225 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 47 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 47
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Val 20 25 30
Pro Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Pro Tyr Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ^ 90 95
Ala Lys Gly He Met Pro Ser Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <230> 48 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 48
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Ser Ala Leu Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 •26·
163920-序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 X) 95
Ala Lys Gly Gin Leu Pro Ala Leu Glu ?hc Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 49 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 49
Glu Val Gin.Leu Leu Glu Ser Gly Gly ijly Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser 0\y Phe Thr Phe Lys Arg Tyr 20 25 30
Tyr Met Thr Trp Val Arg Gin Ala Pro Q\y Lys Asp Leu Glu Trp Val 35 40 45
Ser Gly lie Val Pro Ser Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ')0 95
Ala Lys Gly Arg lie Pro Asp Leu His :?hc Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 50 <211> 122 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 50
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 -27- 163920·序列表.doc 201245225
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Ser Pro Thr Gly Gly Gin Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Tie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Val lie Pro Tyr Leu Ser Phe Ser Pro Phe Asp Tyr Trp 100 105 110
Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 51 <211> 122 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 51
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 20 25 30
Trp Met Gly Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Ser His Gly Ala Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly ATg Phe Thi lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Ala Pro Lys Phe Met Thr Thr Tyr Thr Phe Asp Tyr Trp 100 105 110
Gly Gin Gly Thr Leu Val Thr Val Scr Ser 115 120 <210> 52 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 ·28·
163920·序列表.doc 201245225 <400> 52 GIu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Ser Tyr 20 25 30
Pro Met His Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Ser Arg Gly Ser Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95.
Ala Lys Gly His Ser Trp Thr Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 53 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 53
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Sei Leu Arg Leu Sex Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ser 20 25 30
Asn Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asn Pro Asp Gly Gly Scr Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Glu Gly Arg lie Pro Thr Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 -29- 163920·序列表.doc 201245225 <210> 54 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 54
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Pro Arg 20 25 30
Arg Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Asp lie Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe TTir lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Glu Gly Ala Gin Gly Val Leu Leu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 55 <211> 317 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 55
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr 20 25 30
Arg Met Val Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Thr Ser Gly Glu Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 -30-
163920-序列表.doc 201245225
Ala Glu Thr Ala Gly Gin Phe Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Scr Ser 115 <210> 56 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 56
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Tyr 20 25 30
Glu Met Val Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val
Ser Ala lie Ser Arg Glu Gly Arg Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 W 95
Ala Lys Glu Pro Val Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<2I0> 57 <211> 116 <2I2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 57
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser 31y Phe Thr Phe Ser Thr Tyr 20 25 30
Glu Met Leu Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ser Ser Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val -31 - 163920-序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va] Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Met Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 58 <211> 116 <212> PRT <213>人工序列 <220〉 <223>人工序列之描述：合成多肽 <400> 58
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Glu 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Pro Asn Gly Ala Phe Thr Phe Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Leu Phe Asp Tyr Trp Gly Gin Gly Thr Leu Va] 100 105 110
Thr Val Ser Ser 115 <210> 59 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 59
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -32-
163920-序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Tyr 20 25 30
Asp Met Val Trp Val Arg Gin Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asn Gly Ala Gly Leu Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Sci Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Gin Ser Ala Ser Arg lie Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115
<210> 60 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 60
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 】0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 20 25 30
Glu Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Thr Leu Gly Thr Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Gin Ser Ser Thr His lie Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <230> 61 <211> 117 <212> PRT <213>人工序列 163920-序列表.doc -33-
S 201245225 <220> <223>人工序列之描述：合成多肽 <400> 61
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe lie Arg Tyr 20 25 30
Glu Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Scr Ser lie Ser Ser Ser Gly Trp Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ser Asp Ala His lie Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 62 <211> 117 <212> PRT. <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 62
Glu Val Gin Lea Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ala Tyr 20 25 30
Glu Met Ala Trp Va】Arg Gin A】a Pro Gly Lys Gly Leu G]u Trp Val 35 40 45
Ser Ser lie Scr Asp Asp Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Vai 50 55 60
Lys Gly Ατβ Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Mel Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Leu Gly Gin Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110 -34-
163920·序列表.doc 201245225
Val Thr Val Ser Ser 115 <210> 63 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 63
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Tlir Phe Ala Asp His 20 25 30
Gly Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly He Gly Pro Ser Gly Glu Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg lie Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 64 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 64
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 】5
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser Gin 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -35- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg Ser Asp Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Hr Val Ser Ser 115 <210> 65 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 65
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30
Asp Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg Tie Arg His Pro Gly Gly Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asu Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Val Pro Lys Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val ΉΐΓ Val Ser Ser 115 <210> 66 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 66
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Val Tyr 20 25 30
Trp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -36-
163920-序列表.doc 201245225
Ser Ser lie Asp Pro Gin Gly Gly Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp TTir Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Arg He Pro Asn Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 67 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 67
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Glu 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asn Pro Thr Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Lys lie Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 68 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 68
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly -37- 163920·序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Ser 20 25 30
Glu Met Met Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ala His Asn Gly Gly His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Giy Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Gly His Pro Gin Gin Thr Glu Ala Phe Asp Tyr Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 69 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 69
Glu Met Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Thr Tyr 20 25 30
Asp Met Tyr Trp Val Arg Gin Ala Pro Gly Lys Oly Leu Glu Trp Val 35 40 45
Set Lys lie Ser Pro Asn Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Gin Thr His Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 70 <21l> 116 •38·
163920·序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 70
Glu Val Gin Leu Uu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Giy Phe Thr Phe Ser Val Tyr 20 25 30
Asp Met Arg Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Tip Val 35 40 45
Ser Thr He Ser Ser Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Pro Lys Asn Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 71 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 71
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Glu 20 25 30
Asp Met Thr Trp Va] Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Scr Scr lie Scr Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Tlu Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Arg Thr Arg Ser Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu -39· 163920-序列表.doc 201245225 100 105 . 210
Val Thr Val Ser Ser 115 <210> 72 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 72
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Lys Tyr 20 25 30 lie Met Gly Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asp Tyr Trp Gly Gin His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Arg Ser His Leu lie Pro Leu Gin Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 73 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 73 G]u Val Gin Leu Leu Glu Ser Gly Gly Gly Leu VaL Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30
Ala Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser Tyr Val Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 •40·
163920-序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Lys Ala Leu Arg Gly Glu Ala Phe Thr Glu Arg Phc Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <2]〇> 74 <211> 123 <212> PRT <213>人工序列 <223>人工序列之描述：合成多肽 <400> 74
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phc Thr Phe Gly Pro Tyr 20 25 30
Met Met His Tip Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Glu Val Asn Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Trp Val Gly Ser Lys Thr Ser Ser Asp Lys Ser Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 75 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 75
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Thr 20 25 30 •41 - 163920-序列表.doc 201245225
Glu Met Aia 丁rp Val Arg Gin Ala Pro Gly Lys Gly Leu GIu Trp Val 35 40 45
Ser Ser lie Gly Ser Ala Gly Ala Trp Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys lie Gly Gly His Pro Gin Gly Gin Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 76 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 76
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Pro Arg Glu 20 25 30
Trp Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 丁rp Val 35 40 45
Ser Ser lie Gin Pro Met Gly Gin Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Ser Arg Asn Lys Gly Phe Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 77 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 • 42·
163920-序列表.doc 201245225 <400> 77
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1-5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Glu 20 25 30
Tyr Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Gin Arg Tyr Gly Scr Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys His Glu Ser Asn Trp Glu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Va] Ser Ser 115 <210> 78 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 78
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Scr Gly Phe Thr Phe Ser Val Tyr 20 25 30
Scr Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Thr Pro Asn Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr A]a Val Tyr 丁yr Cys 85 90 95
Ala Lys Thr Leu Gly Arg Gly Ser Tyr Pro Gly Val Asp Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 -43- 163920-序列表.doc 201245225 <210> 79 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 79
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Ser Tyr 20 25 30
Ala Mel Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Thr Ala Asp Gly Thr Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Ser lie Pro Met Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 80 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400〉 80
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30
Asp Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Pro Asn Gly Thr Gly lie Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 -44-
163920·序列表.doc 201245225
Ala Lys Asn Gin Scr Val His His Ma Val Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 81 <211> 319 <2i2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 83
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asn Tyr 20 25 30
Glu Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val
Scr Arg lie Ala Pro His Gly Arg Lea Thr Tyr Tyr Ala Asp Ser Vai 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Gla Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Gin lie Pro Met Leu As? Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Vai Thr Val Ser Ser 115 <210> 82 <211> 121 <212> PRT <2!3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 82
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly I 5 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 20 25 30
Met Met Met Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser His Phe Gly Asp Ιΐιϊ Thr Tyr Tyr Ala Asp Ser Val -45- 163920·序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asti Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asn Asp Met Val Met Lys Asn Gly Gly Phe Asp Tyr Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 83 <2U> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 83
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Ser Arg Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Leu Val Pro His Leu Arg Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 84 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 84
Giu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Ciy 15 10 15 •46· 163920-序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe ThT Phc Ala Asn Ala 20 25 30
Gin Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Asp Ala Met Gly Asp Ah. Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glv. Asp Thr Ala Val Tyr Tyr Cys S5 90 95
Ala Lys Gly Lys Val Pro Ser lie Asp Tyr Trp Gly Gin Gly Thr Leu 100 lOf 110
Val Thr Val Ser Ser 115
<210> 85 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 85
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Set Cys Ala Ala Scr Gly Phe Thr Phe Ala Asn Ala 20 25 30
Gin Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Ala Met Gly Asp Ma Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Tht lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Val lie Pro Ala Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 86 <211> 118 <212> PRT <213>人工序列 •47- 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 86
Glu Val Gin Leu Leu Glu Ser G!y Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gin Asn Asp 20 25 30
Arg Met His 丁rp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu GJn Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gin Thr Gly Thr Asn Arg Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> S7 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 87
Glu Val GIti Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gin Pro 20 25 30
Tyr Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Ala Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg lie Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110 •48·
163920-序列表.doc 201245225
Thr Leu Val Thr Val Ser Ser 115 <210> 88 <2L1> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 88
Glu Val Gin Leu Leu GIu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phc Thr Phe Asp Asn Glu 20 25 30
Asn Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Gly Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Gin Val Pro Glu Leu Leu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 89 <2U> 119 <232> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 89
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Vai Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Fhe Val Ser Ser 20 25 30
Asn Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -49- 163920·序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala VaJ Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Thr Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 90 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 90
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Aia Ala Ser Gly Phe Thr Phe Val Ser Ser 20 25 30
Asn Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg lie Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly loo 105 no
Thr Leu Val Thr Val Ser Ser 135 <210> 91 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 91
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 IS
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 20 25 30
Ser Met Ser Trp Va] Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -50-
163920-序列表.doc 201245225
Ser Arg lie Asn Asp Ala Gly Ser Ser ?hr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp 八sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Thr lie Pro Leu Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 92 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 92
Glu Met Gin l^eu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 ]〇 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Ser Asp 20 25 30
Thr Met Ser Trp Val Arg Gin Ala Pro (lly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Asp Gly Thr Gly Gly Asp I'hr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly ATg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Leu lie Pro Asp Leu Gin I^e Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 93 <2U> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 93
Glu Val Gin Leu Leu Glu Ser Gly Gly (}ly Leu Val Gin Pro Gly Gly -51 · 163920-序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Glu 20 25 30
Glu Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie lie Gly Gly Gly His Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Thr lie Pro I^u Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <21ft> 94 <211> 119 <212> PRT <213>人工序列 <22Q> <223>人工序列之描述：合成多肽 <400> 94
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Glu 20 25 30
Asn Met Thr Trp Val Arg Gin Ala Pro Gly Lys Asp Leu Glu Trp Val 35 40 45
Ser Arg lie Thr Glu Arg Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Mel Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Scr Ser 115 <210> 95 <211> 119 •52·
163920·序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 95
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Glu 20 25 30
Glu Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie lie Gly Gly Gly His Glu Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 g〇
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 96 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 96
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Scr Gly Phe Thr Phe His Glu Thr 20 25 30
Glu Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Asn Arg Leu Gly Gin Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Glu Met Asn Sei Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Gly Leu Val Phe Asp Tyr Trp Gly Gin Gly -53- 163920-序列表.doc 201245225 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> <211> <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 97
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 20 25 30
Ser Met Ser Trp Val Arg Gin Ala Pio Gly Lys Gly Leu Glu T卬 Val 35 40 45
Ser Arg lie Asn Asp Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 乙eu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 98 <211> 119 <212> PRT <213>人工序列
<220> <223>人工序列之描述：合成多肽 <4〇0> 98
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Fro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Glu 20 25 30
Asn Met Thr Trp Val Arg Gin Ala Pro Gly Lys Asp Leu Glu Trp Val 35 40 45
Ser Arg lie Thr Glu Arg Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -54- 163920-序列表.doc 201245225
Lys Gly Arg Phc Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu /.sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Thr Leu Val f^he Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 99 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 99
Glu Val Gin Leu Leu Glu Scr Gly Gly (ily Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Phe Thr Phe Ser Asp Asp 20 25 30
Ser Met Ser Trp Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg I】e Asn Asp A】a Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ')0 95
Ala Lys Gly lie Thr Pro Asn Leu Thr ?he Asp Tyr Trp Gly Gin Gly 100 105 110
Tlir Leu Val Thr Val Scr Scr 115 <210> 100 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 100
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Va] Gin Pro Gly Gly ] 5 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Glu 20 25 30 -55- 163920·序列表.doc 201245225
Pro Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Pro Pro Glu Gly Ala Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Leu lie Pro Asp Leu Gin Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 101 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 101
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gin Asp Ser 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Fro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ala Ala Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg lie Pro Asn Leu Arg Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 102 <211> 119 <212> m <213>人工序列 <220> <223>人工序列之描述：合成多肽 •56-
163920·序列表.doc 201245225 <400> 102
Glu Val Gin Leu Leu Glu Ser Gly Gly Cly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu SeT Cys Ala Ala Ser Gly Phe Thr Phe Val Ser Asp 20 25 30
Thr Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Gly Thr Gly Gly Asp lhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp /.sn Ser Lys Asn ΊΉτ Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Gin Val Pro Glu Leu Leu F^e Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 103 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 103
Glu Val Gin Leu Leu Glu Ser Gly Gly (ily Leu Val Gin Pro Gly Gly 1 5 :.0 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser (Jly Phe Thr Phe Gin Asp Ser 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro <}ly Lys Gly Leu Giu Trp Val 35 40 45
Ser Ala lie Ala Ala Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Aig Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg lie Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 -57- 163920-序列表.doc 201245225 <210> 104 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 104
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Set Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Asp Leu Ala 20 25 30
Glu Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Glu Asp Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Ar£ Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95
Ala Glu Gly Va] He Pro Ser Leu Thr Phe Asp 丁yr 丁rp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 105 <21I> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 105
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Lys 20 25 30
His Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg He Ser Pro Asp Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 -58 -
163920·序列表.doc 201245225
Ala Glu Gly Val lie Pro Ser Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <2iO> 106 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 106
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Asp 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val
Set Arg lie Ala Val Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Lys Thr Pro His Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Le\j Val Thr Val Ser Ser 115
<210> 107 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 107
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Asp Leu Ala 20 25 30
Glu Met Thr Trp Va】Arg Gin A】a Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Glu Asp Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val •59- 163920-序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala GIu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Gin Val Pro Ala Leu Va) Phe Asp Tyr Trp G]y Gin Gly 100 105 110
Thr Leu Va) Thr Val Ser Ser 115 <210> 108 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 108
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Giy 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Ser 20 25 30
Met Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Pro Gly Gly Ala Gin Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Val 'ihr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 109 <211> 319 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 109
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 •60·
163920-序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Scr Gly Phe Thr Phe Glu His Ala 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Ser Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Asn Ser Gly Gin Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Set Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Val Thr Pro Asp Leu ΊΤιτ Fhe Asp Tyr Trp Giy Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <2io> no <211> 119 <212> m <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 110
Glu Val Gin Leu Leu Glu Ser Gly Gly C^ly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Ala 20 25 30
Glu Met Asn Trp Val Arg Gin Ala Pro (fly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Thr Thr Asp Gly Asp Scr l.lir Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Thr Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 111 <211> 119 <212> PRT <213>人工序列 163920-序列表.doc •61 ·
S 201245225 <220> <223>人工序列之描述：合成多肽 <400> 111
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Scr 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Ser Leu Glu Trp Val 35 40 45
Ser Tyr lie Arg Gly Asp Asp Asp Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Tlir lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asn Arg lie Pro Asp Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Scr Ser 115 <210〉 112 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇0> 112
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 】 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Ala 20 25 30
Asp Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Scr Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys His Ala Ser Thr Glu Gly Pro Thr Ala Phe Asp Tyr Trp Gly 100 305 110 •62-
163920·序列表.doc 201245225
Gin Gly Thr Leu Val Thr Val Ser Scr 115 120 <210> 113 <21l> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 113
Glu Val Gin Leu Leu Glu Ser Gly Gly Giy Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe TTir Phe Gly Pro Tyr 20 25 30
Asp Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Va! 35 40 45
Ser Trp lie Ser Ala His Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Ksp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Trp Pro Tyr Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 114 <211> 119 <232> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 114
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Gly 20 25 30
Ser Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Gly Ser Asn Gly Ala Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 •63- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Met Val Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 115 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 115
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Phe 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe ΊΉγ lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg lie Pro Asn Leu Val Phe Asp Tyr Trp Gly Gin Gly loo 105 no
Thr Leu Val Thr Val Ser Ser 115 <210> 116 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 116
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Ser 20 25 30
Asp Met Lys Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -64-
163920·序列表.doc 201245225
Ser Ser lie Ser Pro Asn Gly 丁rp Asp llir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu /.sp Thr Ala Val Tyr Tyr Cys 85 SO 95
Ala Lys Ser Pro Ser Ser Arg Leu Lys Hie Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Va! Thr Val Ser Ser 115 <210> 117 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 117
Glu Val Gin Leu Leu Glu Ser Gly Gly (ily Leu Val Gin Pro Gly Gly 1 5 ]〇 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (fly Phe Thr Phe Asp Ser Ser 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Glu Asn Gin Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thi lie Ser Arg Asp 八sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Lea Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Arg lie Pro Asn Leu Val 1¾ Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 118 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 118
Glu Val Gin Leu Leu Glu Scr Gly Gly 31y Leu Val Gin Pro Gly Gly -65- 163920-序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Ala Tyr 20 25 30
Pro Met Tyr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Trp lie Ala Ser Gly Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Arg Thr Lys Asn Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 119 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 119
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu kxg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Ser Tyr 20 25 30
Ser Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly He Thr Ser Asn Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ser Thr Gly Ala Asn Ser Arg Asn Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 120 <211> 121 -66-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 120
Glu Val Gin Leu Leu Glu Ser Gly Gly (Jly Leu Val Gin Pro Gly Gly 1 5 :.0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (!ly Phe TTir Phe Glu Gly Tyr 20 25 30
Leu Met Ser Trp Val Arg Gin Ala Pro Oly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ala Ala Asn Gly Met Gin "lir Tyr Tyr Ala Asp Str Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp /isn Ser Lys Asn Tht Leu Tyr 65 70 75 δΟ
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 i)0 95
Ala Lys Lys Pro Arg Gly He Trp Asp (!ly Asp Phe Asp Tyr Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 121 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 121
Glu Val Gin Leu L^u Glu Ser Gly Gly (Jly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Scr Cys Ala Ala Ser (31y Phe Thr Phe His Glu Ser 20 25 30
Thr Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Arg His Pro Gly Glu Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 85 X) 95
Ala Lys Gly Leu lie Pro Asp Leu Gin Phe Asp Tyr Trp Gly Gin Gly •67- 163920·序列表.doc 201245225 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 122 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 122
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser G!y Phe Thr Phe Ala Met Tyr 20 25 30
Ser Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ala Pro Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gin Ser Leu Thr Giy Tyr Ser Arg Ser Phe Asp Tyi Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 123 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 123
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Sex Cys Ala Ala Ser Gly Phe Thr Phe Ser Gin Asn 20 25 30
Pro Met Ser Trp Val Arg His Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Pro Ala Asn Gly Arg Pro Thr Ser Tyr Ala Asp Ser Val 50 55 60 • 68 -
163920·序列表.doc 201245225
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala GIu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Ser Gin Gin Pro Gly Arg Arg Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 124 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 124
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Tyr 20 25 30
His Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Pro Asp Ser Gly Lys Gin Ihr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Ser Leu Leu Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Scr Ser 115 <210> 125 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 125
Glu Val. Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 30 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Phe Thr Phe Ala Gin Tyr 20 25 30 -69- 163920-序列表.doc 201245225
His Met Arg Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr He Asn Asp lie Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Val Gly Gly Arg Gly Ser Phe Ser Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 126 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 126
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30
Asp Met Lys Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr He Ser Ala Ser Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr I】e Ser Arg Asp Asn Ser Lys Asn Thr Leu 丁yr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Arg Glu His Ala Gly Gin Pro Pro Phe Asp Tyr 丁rp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 127 <211> 120 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 -70-
163920-序列表.doc 201245225 <400> 127
Glu Val Gin Leu Leu Glu Ser Gly Gly Clly Leu Val Gin Pro G]y Gly i 5 :.0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (Jly Phe Thr Phe Asn Gly Tyr 20 25 30
Ala Met Ser Trp Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asn Ala Asn Gly Lys Tyr ^.Tir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp -asn Ser Lys Asn Thr Lea Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tyr Cys 85 ί)〇 95
Ala Lys Lys Leu Thr Leu Ala Ser Asn Tyr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 128 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 128
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly I-eu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (}ly Phe Thr Phe Met Asp Tyr 20 25 30
Asp Met Lys Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Thr Ala Leu Gly Lys Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Ser Val Lys Tyr Pro Leu ,^sn Leu Phe Asp Tyr Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 71 · 163920-序列表.doc 201245225 <210> 129 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 129
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro His Tyr 20 25 30
Thr Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie G】n Ser Pro Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Gly Asp Gly Leu Pro Leu TTir Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 130 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 130
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Thr 20 25 30
Pro Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Gly Asp Giu Gly Gin Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 •72·
163920-序列表.doc 201245225
Ala Lys Gly Val Thr Pro Asp Leu Thr Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Vai Ser Ser 115 <210> 131 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 131
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30
Ser Met Ser Trp Val Arg Gin Ala Pro (ily Lys Gly Leu G!u Trp Val
Scr Ala lie Gly Ser Asp Gly Pro Ser ITir Tyr Tyr Ala Asp Ser Vai 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Thr Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Va! Thr Val Ser Ser 115
<210> 132 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 132
Glu Val Gin Leu Leu Glu Ser Gly Gly ijly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Sei Gly Phe Thr Phe Asn Pro Gly 20 25 30
Glu Met Thr Trp Val Are Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val •73- 163920·序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr Me Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg lie Pro Thi Leu His Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 133 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇0> 133
Glu Val Gin Leu Leu GIu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Ser 20 25 30
Mel Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Gly Tyr Pro Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Gly Ser Arg Asp Asp Asn Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 134 <211> 124 <212> PRT <2丨3>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇〇> 134
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -74·
163920·序列表.doc 201245225
Ser Leu Arg Leu Scr Cys Ala Ala Ser (jly Phe Thr Phe Gly Gin His 20 25 30
Ser Met His Trp Val Arg Gin Ala Pro (31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Val Pro Gly Pro Lys frhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ')0 95
Ala Lys Scr Leu Arg Asp Leu Arg Pro ()ly Asp Ser Lys Ser Phe Asp 100 105 110
Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> 135 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 135
Glu Val Gla Leu Leu Glu Ser Gly Gly (Jly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser <31y Phe Thr Phe Gly Ser Ala 20 25 30
Ala Met Asp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asn Asp Met Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Tlir Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gin Gly Gly Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 136 <2)]> 118 <212> PRT <213>人工序列 -75- 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 136
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Tht Phe Gly Tyr Asp 20 25 30
Arg Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Gly Pro Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Glu Gly Arg Arg Val Pro Asp Phe Asp Tyr Trp Gly Gin Gly 丁hr 100 105 110
Leu Va] Thr Val Ser Ser 115 <210> 137 <211> 119 <212> PRT <213>人工序列 <220> <2幻> 人工序列之描述：合成多肽 <400> 137
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Tyr 20 25 30
Glu Met Thr Trp Val Arg Gin A3 a Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Pro Phe Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Glu Gly Val Val Pro Asp Leu Asn Phe Asp Tyr Trp Gly Gin Gly 100 105 110 -76-
163920·序列表.doc 201245225
Thr Leu Val Thr Val Ser Ser 115 <210> 138 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 138
Glu Val Gin Leu Leu Glu Scr Gly Gly (jly Leu Val Gin Pro Gly Gly 1 5 10 15 .
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ήιτ Phe Asp Lys Tyr 20 25 30
Val Mel Gly Trp Val Arg Gin Ala Pro (jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Gly Ser Tyr Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 扣 95
Ala Lys Arg Leu Thr Leu Ser Ala Thr Lys Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 139 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 139
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Scr Gly Phe Thr Phe Glu Asp Tyr 20 25 30
Val Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ala His Arg Gly Asp lie Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -77- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Arg Arg Arg Leu Ser Asp Tyr Arg Phe Asp Tyr 丁rp Gly G]n 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 140 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 140
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gin Phe 20 25 30
Asp Met Tyr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Jle Ser Pro Ala Gly Thr Gly Thr Tyr Tyr Ala Asp Ser Va1 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va] Tyr Tyr Cys 85 90 95
Ala Lys Ala Gly Asp Arg Ser Ser Leu Phe Asp Tyr Arg Gly Gin Gly 100 105 110
Thr Leu Vai Thr Val Ser Ser 115 <210> 141 <211> 118 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 141
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Set Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Thr 20 25 30
Gly Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 •78·
163920-序列表.doc 201245225
SerSerlle Ser Ser Tyr Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala GIu Asp Ala Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Asn Ala Ala Leu Gly Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 142 <211> 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 142
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe rrhr Phe Gly Pro Tyr 20 25 30
Pro Met Ser Trp Val Arg Gin Ala Pro (fly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Asn Ala Pro Gly Thr Arg Ί,Ήγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Ήιτ Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Gin Gin Met Ser Ser Gly Val Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 143 <211> 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 143
Glu Val Gin Leu Leu Glu Ser Gly Gly 31y Leu Val Gin Pro Gly Gly -79· 163920-序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Phe Ser Asn Gin 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Ser Ser Gly Gin Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Val Lys Ser Leu Ala Arg Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Va) Thr Val Ser Ser 115 <210> 144 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 144
Glu Va] Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Ser 20 25 30
Asp Met Lys Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Pro Ala C]n Val Leu Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 145 <211> 120 •80-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 145
Giu Val Gin Leu Leu Glu Ser Gly Gly (51y Leu Val Gin Pro Gly Gly 1 5 :·0 15
Ser Leu Arg Leu Sei Cys Ala Ala Ser (；ly Phe Thr Phe Glu Gin Tyr 20 25 30
Val Met Gly Trp Val Arg Gin Ala Pro (}ly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Gly Thr Ser Gly Lys Tyr r;Tir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Gin Arg Arg Ser Leu Thr Arg Val His Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 146 <211> 119 <212> PRT <2U>人工序列 <220> <223>人工序列之描述：合成多肽 <400> ]46
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Val Glu 20 25 30
His Met Ser Trp Val Arg Gin Ala Pro (31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Thr Gly Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 W 95
Ala Lys Thr Val Ser Trp Asn Gly Arg Phe Asp Tyr Trp Gly Gin Gly •81 · 163920-序列表.doc 201245225 100 105 110
Thr Leu Val Thr Val Ser Scr 115 <210> 147 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 147
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Trp Tyr 20 25 30
Asn Met Cly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Ala Pro Ser Gly lie lie Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Leu Arg Gly Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 148 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 148
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly I^eu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe SeT Asn Tyr 20 25 30
Glu Met Arg Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ser Ala Gly Thr Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -82·
163920-序列表.doc 201245225
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gin Sex Leu Asn Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 149 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 149
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser (!ly Phe Thr Phe Asp Glu Glu 20 25 30
Fro Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser He lie Asp Pro Gly Gly Gly Ala ^.Tir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp /isn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tvr Cys 85 !)0 95
Ala Lys Ser Asn Sex Met Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 150 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 150
Giu Val Gin Leu Leu Glu Set Gly Gly '31y Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser 31y Phe Thr Phe Ser Ala Tyr 20 25 30 •83· 163920-序列表.doc 201245225
Pro Met His Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ala Ser Ser Gly lie Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Phe Thr Arg Leu His Phe Pro Ala Gin Phe Asp Tyr Trp Gly 100 105 110
Gin Gly ΤΉγ Leu Val Thr Val Ser Ser 115 120 <210> 151 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 151
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30
Ala Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Ser Pro Glu Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Arg Pro Tyr Ala Ser Lys Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 152 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -84-
163920-序列表.doc 201245225 <4〇0> 152
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Giy Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Cly Phe Thr Phe Arg Pro Tyr 20 25 30
Asp Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Tip Val 35 40 45
Ser Thr lie Ser His Glii Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Ήιγ Leu 65 70 75
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 SO 95
Ala Lys Val Ser His His Phe Asp Tyr I'rp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 153 <211> 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 153
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 ：i0 15
Ser Leu Arg Leu Set Cys Ala Ala Ser (；ly Phe Thr Phe Ser Ala Tyr 20 25 30
Asn Met Trp Trp Ala Arg Gin Ala Pro (Jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Trp lie Asn Ser Thr Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asn Trp His Arg Gly Arg Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 -85- 163920-序列表.doc 201245225 <210> 154 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 154 GIu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Arg Tyr 20 25 30
Arg Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asn Arg Leu Gly Gin Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Val Lys Lys His Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 155 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 155
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala His Tyr 20 25 30
Asn Met Arg Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Thr Lys Thr Gly Phe Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn SeT Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 • 86 -
163920-序列表.doc 201245225
Ala Lys Ala Gly Gin Phc Asp Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 156 <211> 118 <212> m <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 156
Glu Val Gin Leu Leu G)u Ser Gly Gly (31y l^u Val Gin Pro Gly Gly 1 5 ：0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (Jly Phe Thr Phe Tyr Pro Tyr 20 25 30
Ser Met His Trp Val Arg Gin Ala Pro (Jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asp Gly Ser Gly Met Phe rrhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala VaJ Tyr Tyr Cys 85 !)0 95
Ala Glu Asp Ser Leu Lys Ala Ser Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 157 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 157
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 IS
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Leu Tyr 20 25 30
Gly Met Trp Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Tyr lie Gly Pro Tyr Gly His Thr Dir Tyr Tyr Ala Asp Ser Val •87· 163920·序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Lys Arg Lys Lys Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 158 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 158
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Arg Tyr 20 25 30
Arg Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser He Thr Pro Tyr Gly Ala His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys S5 90 95
Ala Lys Tyr Gly Lys Trp Tyr Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 159 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <40Q> 159
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -88 - 163920·序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Phe Thr Phe Asn Glu Tyr 20 25 30
Ala Met Arg Trp Val Arg Gin Ala Pro (fly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asp Arg Leu Gly Leu His llir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Scr Gly Pro Phe Thr Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Va】Thr Va丨 Ser Ser 115
<210> 160 <2I1> 117 <212> PRT <213>人工序列. <220> <223>人工序列之描述：合成多肽 <400> 160
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 :.0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30
Asn Met Arg Tip Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asp Arg Leu Gly Leu Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Gly Ser Trp Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 161 <211> IIS <212> PRT <213>人工序列 •89- 163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 161
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 】5
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly lie Tyr 20 25 30
Asp Met Lys Trp'Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser Ser Ser Gly Thr His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Pro Gin Pro Tyr Pro Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Scr 115 <210> 162 <211> 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 162
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala A!a Ser Gly Phe Thr Phe Trp Val Tyr 20 25 30
Asp Met Arg Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser Ala Thr Gly Val His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Jle Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Pro Pro Ala Gly Arg Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110 -90-
163920·序列表.doc 201245225
Leu Val Thr Val Ser Ser 115 <210> 163 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 163
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30
Asp Met lie Trp Va] Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Fro Asn Gly Thr Gly 'dir Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 !)0 95
Ala Lys Pro Pro Gin Val Asn Thr Glu Phe Asp Tyr Arg Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 164 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 164
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Lys Glu 20 25 30
Asp Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu G】u 丁rp Val 35 40 45
Ser His lie Ser Pro Asn Gly Tyr Ala Πιγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 •91· 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va] Tyr Tyr Cys 85 90 95
Ala Lys Ser Trp Ser Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 165 <211〉 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 165
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phc Ser Ala Thr 20 25 30
Pro Met Glu Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser Glu Ser Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Trp Asn Ser Thr Thr Gly Phe Asp Tyr Trp G】y GJn Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 166 <211> 117 <2).2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 166
Glu Val Gin I^u Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 IS
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Val 20 25 30
Asp Met Glu Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 •92·
163920·序列表.doc 201245225
Ser Scr lie Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Tht lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Uu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 50 95
Ala Glu Ala Pro His Arg Ala Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 167 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 167
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser C:ly Phe Thr Phe Glu Asp Lys 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Scr Arg lie Asp Ala Leu Gly Asp Ser Ihr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp /.sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 % 95
Ala Glu Gly Met Val Pro Arg Leu Lys I'he Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Va] Ser Ser 115 <210> 168 <211> 114 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 168
Glu Val Gin Leu Leu Glu Ser Gly Gly (Hy Leu Val Gin Pro Gly Gly -93- 163920-序列表.doc 5 201245225 15 10
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 20 25 30
Ser Met Met Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Asp lie Glu Pro His Gly Val His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Asn Pro Thr Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val 100 105 110
Ser Ser
<210> 169 <211> 122 <212> PRT <213>人工序列 <22Q> <223>人工序列之描述：合成多肽 <400> 169
Glu Val Gin Leu Leu Glu Ser Gly GJy Gly Leu Val GJn Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro His 20 25 30
Thr Met His Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Gly Pro Asp Gly Thr Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Atg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Arg Ser Tyr Ser Trp Asp Arg Gly Trp Thr Phe Asp Tyr Trp 100 105 110
Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 170 <211> 119 -94- 163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 170
Glu Val Gin Leu Leu Glu Scr Gly Gly 31y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser 3Iy Phc Trhr Phe Tyr Ala Ser 20 25 30
Asp Met Lys Trp Val Arg Gin Ala Pro jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Pro Asn Gly Trp Asp ihr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Asp Tyr Thr Tyr His Ser Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 171 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 171
Glu Val Gin Leu Leu Glu Ser Gly Gly Sly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala His Tyr 20 25 30
Asn Met Arg Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Scr Thr lie Thr Lys Thr Gly Phe Arg Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thx lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Gly Gin Phe Asp Phe Asp Tyr Trp Gly Gin Gly Thr Leu -95- 163920-序列表.doc 201245225 100 105 110
Val Thr Va】Ser Ser 115 <210> 172 <211> 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 172
Glu Val Gin l^u Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 20 25 30
His Met Gly Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Val lie Gly Pro Arg Gly lie Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ser Pro Ser Arg His Arg Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 173 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 173
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr 20 25 30
Ala Met Arg Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Asp Arg Leu Gly Leu His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -96·
163920·序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ser Gly Pro Phe Thr Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 174 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 174
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thx Phe Gly Asn Tyr 20 25 30
Scr Met Lys Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Thr Pro Asp Gly Trp Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 g〇
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Val Gly Asp Ala Val Trp Gly Trp lie Gly Gly Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Scr Scr 115 120 <210> 175 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 175
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 •97· 163920-序列表.doc 201245225
Gly Met Lys Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Thr Ser Asn Gly Asp Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ser Leu Tyr Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 176 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 176
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Pro Thr Tyr 20 25 30
Lys Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Phe He Asp Tyr Trp Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ser Pro Tyr Ser Trp Thr His Asp Ser Pro His Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 177 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -98-
163920-序列表.doc 201245225 <400〉 177
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Pro Tyr 20 25 30
Thr Met Cys Trp A!a Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Cys lie Ser Asp Ala Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Arg Met Ser Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Scr 115 <2I0> 178 <211> 122 <212> PRT <213>人工序列 <220> <M3>人工序列之描述：合成多肽 <400> 178
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Gin Asn Tyr 20 25 30
Gin Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser Gly Thr Gly Lys Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Thr Pro Gin Asn Tyr Phe Ser Val Arg Arg Phe Asp Tyr Trp 100 105 110
Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 -99- 163920-序列表.doc 201245225 <210> 179 <211> Π8 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 179
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Tyr 20 25 30
Thr Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Lys lie Ser Thr Ser Gly Gly Gin Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Uu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys S5 90 95
Ala Lys Pro Leu Asn Trp Trp Ala Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 180 <2]1> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 】80
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Tyr 20 25 30
Pro Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Arg lie Asp Gly Tyr Gly Arg His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 •100-
163920-序列表.doc 201245225
Ala Lys Gly lie lie Pro Asn Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 10:5 110
Val Thr Val Ser Ser 115 <210> 181 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 181
Glu Val Gin Leu Leu Glu Ser Gly Gl> Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Sei Gly Phe Thr Phe Gly Ala Val 20 25 30
Asp Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Pro Ser Gly Ser Ala Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thi Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Arg Val Pro Asp Leu Gly Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <2]〇> 182 <211> 117 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 182
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 20 25 30
Ala Met Gly Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Gly Ala Lys Gly Leu Scr Thr Tyr Tyr Ala Asp Ser Val -101 - 163920-序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Ala Arg Gly Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 183 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 183
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Arg Tyr 20 25 30
Gin Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Val lie Asn Val Trp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Met Ser Gly Lys Phe Ala Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 184 <211> Π7 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 184
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -102- 163920·序列表.doc 201245225
Scr Leu Arg Leu Ser Cys Ala Ala Sei: Gly Phe Tlir Phe Gly Asn Tyr 20 25 30
Ser Met Met Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie lie Pro Ala Giy Thr Ser Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr lyx Cys 85 90 95
Ala Lys Pro Scr lie Arg Leu Phe Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110
Val Thr Val Ser Ser 115 <210> 185 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 185
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Tyr 20 25 30
Asp Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Trp lie Ser Pro Asn Gly Tyr Asp Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Gly Val Lys Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Va! Ser Ser 115 <210> 186 <211> 123 <212> PRT <213>人工序列 -103- 163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 186
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Trp Tyr 20 25 30
Glu Met Ala Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Gin Ala Asp Gly Glu Gin Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Pbe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ala Ser Tyr Ala Leu Val Tyr Pro Pro Glu Glu Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 187 <211> 122 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 187
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30
Arg Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Asp Asp Leu Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Trp Arg Leu Lys Asn Ser Gin Pro Thr Asp Phe Asp Tyr Trp 100 105 110 -104-
163920·序列表.doc 201245225
Gly Gin Gly ΏΐΓ Leu Val Thr Vd Ser Ser Π5 120 <210> 188 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 188
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gin Ala 20 25 30
His Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Phe He Asn Pro Ser Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Ήιγ lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Pro Scr Leu Ser Pro Scr Ser Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Vai Thr Val Scr Ser 115 <210> 189 <211> 118 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 189
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Thr Gly 20 25 30
Gin Met Gly Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Scr Asn He Asp Gly Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -105- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Ser Thr Gin Asn Tyr Arg Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 190 <211> 119 <212> PRT <213>人工序列 <220> <2S3>人工序列之描述：合成多肽 <400> 190
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Tyr 20 25 30
Pro Met Tyr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie His Lys Asp Gly Arg lie Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gin Gly Thr Pro Val Asp Gly Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <2]〇> 191 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 191
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Hu Phe Pro Asp Glu 20 25 30
Gly Met Thr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -106- 163920·序列表.doc 201245225
Scr Thr lie Glu Thr Gly Gly Thr Val Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Met Asp Gly Ser Gly Thr Trp Gin Thr Phe Asp Tyr Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 192 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 192
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser I^u Arg Leu Scr Cys Ala Ala Se;: Gly Phe Thr Phe Asp Ser Leu 20 25 30
Gly Met Gly Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Scr Tyr lie Arg Ala Glu Gly Ala Tyv Tlu Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Git. Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Leu Ala Asp Ser Asp Tyi Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 193 <211> 120 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 193
Glu Val Gin Leu Leu Glu Ser Giy Gly Gly Leu Val Gin Pro Gly Gly -107- 163920·序列表.doc 201245225 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Ser 20 25 30
Tyr Met Glu Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Asp His He Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Asp Gly Arg Gly Gly Ser Met Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 194 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 194
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Gly 20 25 30
Tyr Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Gly Ala Ser Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Thr Gly Gly Arg Leu Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 195 <211> 119 • 108 ·
163920·序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 195
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Fhe Asp Glu Gly 20 25 30
His Met Gly Trp Val Arg Gin Ala Prc Gly Lys Asp Leu Glu Trp Val 35 40 45
Ser Tyr He Gly Ser Leu Gly Leu His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va] Tyr Tyr Cys 85 90 95
Ala Lys Arg Glu Phe Ser Asn Gly Gly Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 196 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 196
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Fhe Thr Phe Lys Thr Ser 20 25 30
Pro Met Tyr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Asp Arg Thr Gly Gly His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Aig Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gin Ala Leu Leu Thr Asp Ala Lys Arg Phe Asp Tyr Trp Gly -109- 163920-序列表.doc 201245225 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 197 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 197
Glu Val G1q Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Arg 20 25 30
Asp Met Val Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Pro Ser Gly Leu Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Glu Arg Pro Gin Met Leu Val Thr Asn Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 198 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 198
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe TTir Phe Gly Asn Asp 20 25 30
Pro Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Gly Arg Glu Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -110- 163920·序列表.doc 201245225
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Ser Met Arg His Gin Pro Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Va] Ser Ser 115 <210> 199 <2U> 119 <232> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 199
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Thr 20 25 30
Tyr Met Lys Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Gly Ala Ser Gly Ala Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Phe Thr His Leu Asn Gly Arg Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 200 <211> 119 <212> PRT <213>人工序列 <22Q> <223>人工序列之描述：合成多肽 <400> 200
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Trp 20 25 30 -111 - 163920-序列表.doc 201245225
Pro Met Gly Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Asp lie Asp Gly Ala Pro Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Glu Ala Gly Ser Trp Ser Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 201 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 201
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Gin 20 25 30
Ala Met Trp Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Phe lie Gin Gly Asp Gly Gly Phe Thr Tyr Tyr A]a Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Pro Ser Lys Pro Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 1.00 105 110
Thr Val Ser Ser 115 <210> 202 <211> 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -112- 163920-序列表.doc 201245225 <400> 202
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Thr Gly 20 25 30
Gl, Met Gly Trp Ala Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val
Ser Asn lie Asp Gly Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala lys Ala Val Arg Asn Phe Ala Phe Asp Tyr Trp Gly Gin Gly Thr 100 105 110
Leu Val Thr Val Ser Ser 115 <210> 203 <211> 124 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 203
Glu Val Gin Leu Leu Glu Ser Gly Gly Giy Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly His 20 25 30
Asp Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Pro His Gly Thr His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Mel Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly lie Arg Gly Trp lie Gly His Asp Thr Gin Pro Phe Asp 100 105 110
Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 163920-序列表.doc •113-
S 201245225 <210> 204 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 204
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser Lys 20 25 30
Asp Met Leu Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser He Ser Ser Asp Gly Thr His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Tlir lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Le\x Gin Met Asn Ser Leu Arg Ala Glu Asp Ίήτ Ala Val Tyr Tyr Cys 85 90 95
Ala Gin Glu Leu Gly Gly Ser Trp Gin Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 205 <211> 122 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 205
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Arg 20 25 30
Asp Met Val Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 丁rp Val 35 40 45
Ser Gly lie Gly Ala Ser Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 -114-
163920-序列表.doc 201245225
Ala Lys Gly Gly Thr Gly Pro Thr Asp Leu Trp Asp Phe Asp Tyr Trp 100 105 110
Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 206 <2il> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 206
Glu Val Gin Leu Leu Glu Ser Gly Gly C!ly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Glu 20 25 30
Lys Met Leu Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser He Ser Val Ser Gly Leu His 1ΪΓ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Glu Ala Gly Ser Trp Ser Phe Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 207 <211> 119 <212> PRT <213>人工序列 <220> <2：»>人工序列之描述：合成多肽 <400> 207
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gin Glu 20 25 30
Arg Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Asp lie Ser Ala Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val •115· 163920·序列表.doc 55 201245225 50
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Glu Ala Gly Ser Trp Ser Phc Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 208 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 208
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Met Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val fryr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 209 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 209
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 •116-
163920·序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser 3ly Phe Thr Phc Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro 31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg fhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Aig Ala Glu .^sp Thr Ala Val Tyx Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 210 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 210
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Val Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 211 <211> 116 <212> mi <213>人工序列 -117- 163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 211
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Scr 115 <210> 212 <211> 316 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400〉 212
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp He 35 40 45
Ser Ala He Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Val Gin Gly Thr Leu Val 100 105 110 •118-
163920-序列表.doc 201245225
Thr Val Ser Ser 115 <210> 213 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 213
Gin Pro Gly Gly 15
Glu Val Gin Leu Leu Glu Ser Gly Oly Gly Leu Val 1 5 10
Ser Leu Arg Leu Ser Cys Ala Ala Ser '3ly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly Asp Gly Tyr Arg 'Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Scr Scr 115 <210> 214 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 214
Glu Val Gin Leu Leu Glu Thr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30 GJu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -119- 163920-序列表.doc 201245225
Leu Gin Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 】10
Thr Va丨 Thr Ser 115 <210> 215 <2I1> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 215
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe His Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 216 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 216
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Val Ala Ser Gly Phe Thr Phe Glu Trp Tvr 20 25 30
Glu Met Gin Trp Val Arg Gin Ala Pro Gly Asn Gly Leu Glu Trp lie 35 40 45 -120-
163920-序列表.doc 201245225
Ser Ala lie Ser Gly Asp Gly Tyr Arg "Ήγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 % 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Scr 115 <210> 217 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 217
Glu Val Gin Leu Leu Glu Ser Gly Gly (Jly Leu Val Gin Pro Gly Gly 15 丨0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (jly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Leu Met Asn Ser Leu Arg Ala Glu \sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 218 <211> 116 <212> mi <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 218
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly -121 - 163920·序列表.doc 201245225 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 219 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 219
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Met Arg Leu Ser Cys Ala Ala Ser Giy Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Ars Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg A]a Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 220 <211> 116 -122-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 220
Glu Val Gin Leu Leu Glu Ser Gly Gly C!ly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Tip Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro (fly Lys Gly Leu Glu Trp Val 35 40 45
Ser Met lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu /isp Thr Ala Val Tyr Tyr Cys 85 % 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly frhr Lea Val 100 105 110
Thr Val Ser Set 115 <210> 221 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 221
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser I^u Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro 31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 . 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val •123- 163920-序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 222 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 222
Glu Va】Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Va) 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg.Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Leu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 223 <2】1> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 223
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Fro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -124·
163920·序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Xsn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gly Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 224 <211> 116 <212> PRT <213>人工序列 <220> 人工序列之描述：合成多肽 <400> 224
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Glu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 225 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 225
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe rrhr Phe Glu Trp Tyr 20 25 30 -125- 163920·序列表.doc 201245225
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Gly Leu Glu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 1.05 110
Thr Val Ser Ser 115 <210> 226 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 226
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Ala Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 227 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -126-
163920-序列表.doc 201245225 <400> 227
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Cfly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ksp Thr Ala Val Tyr Tyr Cys 85 c'O 95
Ala Lys Glu Leu Leu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <2]〇> 228 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 228
Glu Val Gin Leu Leu Glu Ser Gly Gly (；ly Leu Val Gin Pro Gly Gly 1 5 ：10 15
Ser Leu ATg Leu Ser Cys Ala Ala Ser Oly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Glu Phe Phe Asp Tyr frp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 -127· 163920-序列表.doc 201245225 <210> 229 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 229
Glu Va] Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Ττρ Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 • Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gin Phe Fhe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 230 <211> 116 '<212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 230
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15 _
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 -128-
163920-序列表.doc 201245225
Ala Lys Glu Leu Lea Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 231 <211> 116 <212> PRT <213>人工序列 <220> 人工序列之描述：合成多肽 <400> 231
Glu Val Gin Leu Leu Glu Ser Gly Gly (51y Leu Val Arg Pro G]y Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (Jly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro (Jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg #fhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 i>0 95
Ala Lys Glu Leu Glu Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 232 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 232
Glu Val Gin Leu Leu Glu Ser Gly Gly (Jly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (Jly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Tip Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Tyr Tyr Ala Asp Ser Val -129- 163920-序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Lea Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Leu Phe Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 233 <2ll> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 233
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe lie Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asn Leu Glu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 234 <211> 116 <212> PRT <2〗3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 234
Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -130-
163920-序列表.doc 201245225
Ser Leu Arg i^eu Scr Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg 7hr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Leu Gin Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 235 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 235
Glu Val Gin Leu Leu Gly Ser Gly Gly Cly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Crly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp hsn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg A】a Glu 八sp Thr Ala Val Tyr Tyr Cys 85 i)〇 95
Ser Lys Glu Pro Phe Arg Phe Asp Tyr 7rp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 236 <211> 116 <212> PRT <213>人工序列 • 131 - 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 236
Gla Val Gin Leu Leu Ala Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 237 <211> 116 <212> ?KY <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 237
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Lea Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu C!a 20 25 30
Glu Met He Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp lie 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110 -132-
163920-序列表.doc 201245225
Thr Val Ser Ser 115 <210> 238 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 238
Glu Val Gin Leu Leu Asp Pro Gly Gly Gly Leu Val Gin Pro G3y Gly 1 5 L0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phc Gly Lys Glu 20 25 30
Glu Met ile Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Tip Val 35 40 45
Scr Ser lie Scr Gly Scr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp ksn Ser Arg Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 239 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 239
Glu Val Gin Leu Leu Gly Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 . 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phc Glu Glu Glu 20 25 30
Glu Met Ile Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ihr Leu Tyr 65 70 75 80 •133- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 1)5 <210> 240 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 240
Glu Val Gin Leu Leu Glu Pro Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Scr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn TTir Leu Tyr 65 70 75 80
Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ser Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Ala Leu Vai 100 105 110
Thr Va) Ser Ser 115 <210> 241 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 241
Glu Val Gin Leu Leu Asp Pro Gly Gly Giy Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Lys Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -134-
163920-序列表.doc 201245225
Ser Ser lie Ser Gly Ser Giy Gly Ser ITir Tyr Tyr Ala Asp Scr Val 50 55 60
Lys G]y Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Tlir Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu hsp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Vrp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 242 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 242 G!u Val Gin Leu Leu Glu Ser Gly Gly <31y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Giu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro <31y Lys Gly Leu Glu Trp lie 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser 'llir Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie His Arg Asp .\sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp ΊΉγ Ala Val Tyr Tyr Cys 85 90 95
Ser Lys Glu Pro Phe Arg Phe Asp Tyr Arg Gly Leu Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 243 <211〉 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 243
Glu Val Gin Leu Leu Asp Pro Gly Gly Gly Leu Val Gin Pro Gly Gly •135- 163920-序列表.doc 201245225 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Lys Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 130
Thr Val Ser Ser 115 <230> 244 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 244
Glu Val Gin Leu Leu Asp Ser Gly Gly Gly Phe Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Clu Trp lie 35 40 45
Ser A]a lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 245 <211> 116 -136-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 245 GIu Val Gin Leu Leu Asp Pro Gly Gly Gly Leu Val Gin Pro Gly Gly 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp lie 35 40 45
Ser Ala lie Ser Gly Scr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr 65 70 75 80
Leu Gin Mel Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Arg Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 246 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 246
Glu Val Arg Leu Leu Glu Ser Gly Glu Gly Leu Val Gin Pro Gly Gly 1 5 10 1.5
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Thr l^u Val •137· 163920-序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 247 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 247
Gla Val Gin Gin Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Scr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Ώιγ lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 248 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 248
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 •138· 163920-序列表.doc 201245225
Lys Gly Arg Phc Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ?0 95
Gly Lys Glu Pro Phe Tyr Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 249 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 249
Glu Val Gin Leu Leu Ala Ser Gly Gly 31y Leu Val Gin Pro Gly Gly 15 !0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser jly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro [Jly Lys Gly Leu Glu Trp Val 35 40 45
Scr Ala lie Ser Gly Ser Gly Gly Scr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Tyr Phe Asp Tyr Trp Gly G)n Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 250 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 250
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Va> Gin Fro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Lys 20 25 30 -139- 163920-序列表 _doc 201245225
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Scr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Phe Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 251 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 251
Glu Va] Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Gin Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Fro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 252 <211> 116 <212> PRT <213>人工序列 <220> <2〗3>人工序列之描述：合成多肽 •140-
163920·序列表.doc 201245225 <400> 252
Glu Val Gin Leu Leu Ala Ser Gly Gly (Jly Leu Val Gin Pro Gly Gly l 5 ],0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Ala A!a 20 25 30
Glu Met He Trp Val Arg Gin Ala Pro (lly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Tiir Ala Val Tyr Tyr Cys 85 % 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr 7rp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 253 <211> 116 <2!2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 253
Glu Val Gin Leu Leu Ala Ser Gly Gly (Jly Leu Val Gin Pro G!y Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (jly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Arg Pro Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu \sp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 -141 - 163920-序列表.doc 201245225 <210> 254 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 254
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Met Gly Phe Ser ΊΤιγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 255 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 255
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Fro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Trp Gly His Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Ars Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 9S •142·
163920-序列表.doc 201245225
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Vai Ser Ser 115 <210> 256 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 256
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 】 5 30 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Leu Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp 八sn Ser Lys Asn Thr Leu 丁yr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Tlir Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 Π0
Thr Val Ser Ser 115 肽 多 成 合 述 描 之 ΊΊ 歹 歹 序 序 5716RTU j 1 CU人人 0>1>2>3>0>3> u 1 111 ΟΛ <400> 257
Glu Val Gin Leu Leu Ala Ser Gly Gly 31y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Trp Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 163920-序列表.doc -143- 201245225 50 55 60
Lys Gly Arg Phe Thr He Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 C1y Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 258 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 258
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Gin Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg A]a Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 259 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 259
Glu Val Gin Leu Leu AJa Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -144·
163920-序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Phc Thr Phc Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Scr Val Ser Gly Trp Ser r..Tir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 !)0 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 260 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 260
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Set Cys Ala Ala Ser Gly Phe Thr Phc Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Trp Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr leu Tyr 65 70 75 80
Leu Gin Met Asn Set Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 261 <211> 116 <212> PRT <213>人工序列 -145- 163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 261
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Tlir Fhe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Giy Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <21Q> 262 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 262
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30 .
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly Leu Gly Trp Ser Ίΐιτ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110 •146-
163920-序列表.doc 201245225
Thr Val Ser Ser 115 <210> 263 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 263
Glu Val Gin Leu Leu Ala Ser Gly G]y Oly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (31y Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro (j]y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Ala Leu Gly Trp Ser 'Fhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp i^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Scr 115 <210> 264 <211> 116 <212> PRT <213>人工序列 <220> <2〗3>人工序列之描述：合成多肽 <400> 264
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly ] 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Arg Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 •147- 163920·序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 丨 05 110
Thr Val Ser Ser 115 <210> 265 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 265
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg His Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Are Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly TTir Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 266 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 266
Glu Va) Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 •148· 163920-序列表.doc 201245225
Ser Ser lie Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Vat 50 55 60
Lys Gly Arg Phe ΊΤιγ lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 丁yr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 no
Thr Val Ser Ser 115 <210> 267 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 267
Glu Val Gin Leu Leu Ala Set Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg lie Gly Asn Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 268 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 268
Glu VaJ Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly -149- 163920·序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly His Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110 ^Val %Ser <210> 269 <211> 116 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 269
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Sex Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Trp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu G】n Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys G)u Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Va) 100 105 110
Thr Val Ser Ser 115 <210> 270 <211> 116 -150-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 270
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gla Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 丁rp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Set Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Met Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 271 •<211> 116 <2U> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 271
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Pro Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val -151 - 163920·序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 272 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 272
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 . 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Tlu Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 273 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 273
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -152-
163920·序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gla Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Leu Tyr Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 305 110
Thr Val Ser Ser 115 <210> 274 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 274
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser A]a lie Ser Gly Ser Gly Gly Ser Tlir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Giu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Met Tyr Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 275 <211> 116 <212〉 PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 275
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30 -153- 163920-序列表.doc 201245225
Glu Met I!e Trp Val Arg Gin Ala Pro Gly Lys Gly Leu G】u Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Phe Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Uu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Ττρ Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 276 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 276
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly I 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Mel lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 277 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -154-
163920-序列表.doc 201245225 <400> 277
Glu Val Gin Lxu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 L0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phc Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Glu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 278 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 278
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser jly Phe Pro Phe Glu Glu Glu 20 25 30
Glu Met He Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Gin Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 -155- 163920-序列表.doc 201245225 <210> 279 <211> 1)6 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 279
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Uu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 280 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇〇> 280
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala He Ser Arg Thr Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 -156-
163920-序列表.doc 201245225
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 281 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 281
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser jly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Tie Ser Arg Asn Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asa Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 282 <211> 116 <212> PRT <213>人工序列 <220〉 <223>人工序列之描述：合成多肽 <400> 282
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie 丁rp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val -157- 163920-序列表.doc 55 201245225
Lys Giy Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Va] Ser Ser 115 <210> 283 <211> 116 <212> PRT <2i3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 283
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met He Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Jle Ser Arg Lys Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Clu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 284 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 284
Glu Val Gin Leu Lea Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15 -158-
163920·序列表.doc 201245225
Ser Leu Arg Leu Scr Cys Ala Ala Ser (lly Phe Thr Phe Glu Olu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Gly Gly Trp Ser ".Tir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp nsn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu yvsp Thr Ala Va! Tyr Tyr Cys 85 ΐϊ〇 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 285 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 285
Glu Val Gin Leu Leu Ala Ser Gly Gly i]ly Leu Val Gin Pro Gly Gly L0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met He Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
SeT Ala lie Ser Arg Ser Gly Tyr Ser Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 286 <211> 136 <212> PRT <213>人工序列 •159. 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 2S6
Glu Val Gin Leu Leu Ala Ser Gly Gly Giy Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Met Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Sei Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg A】a Glu Asp Thr Ala Va】丁yr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Vai Ser Ser 115 <210> 287 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 287
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Giy Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Giy Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110 -160·
163920-序列表.doc 201245225
Thr Val Ser Ser 115 <210> 288 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 288
Glu Val Gin Leu Leu Glu Ser Gly Glu Gly Leu Val Gin Pro Gly Gly 3 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu His 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ,\sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Pro Glu \sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 289 <2I1> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 289
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Scr Thr Phe Thr Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp lie 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Tlir lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -161 - 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Arg Cly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 290 <211> 116 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 290
Glu Val Gin Leu Leu Glu Pro Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Lys Ala Pro Gly Lys Gly Met Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80
Leu Gin Me: Asn Ser Leu Arg A】a Glu Asp Thr Ala Va】Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Gly Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210〉 291 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 291
Glu Val Gin Leu Leu Asp Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -162- 163920-序列表.doc 201245225
Ser Ser lie Ser Gly Asn Gly Ala Asn r,.Tir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Atg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tyr Cys 85 % 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Arg Gly Thr I^eu Val 100 305 110
Thr Val Ser Ser 115 <210> 292 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 292
Glu Val Gin Leu Leu Gly Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Ser Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Tyr Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 293 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <40Q> 293
Glu Val Gin Pro Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly •163· 163920-序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Scr Cys Ser Ala Ser Gly Phe Thr Phe Asn Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va】Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 294 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 294
Glu Val Gin Leu Leu Glu Ser Gly Glu Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 295 <211> 116 •164· 163920·序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 295
Glu Val Gin Leu Leu Asp Pro Gly Gly 'jly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phc Thr Phe Thr Glu Ser 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu \sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 296 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 296
Glu Val Gin Leu Leu Glu Pro Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30
Glu Met lie Trp Val Arg Lys Ala Pro Gly Lys Gly Met Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phc Asp Asp Trp Gly Gin Gly Thr Leu Val -165- 163920-序列表.doc 5 201245225 100 105 110
Thr Va] Ser Ser 115 <210> 297 <21!> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400〉 297
Giu Val Gin Leu Leu GIu Ser Gly Val Giy Leu Val Gin Pro Gly Cly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Giu Tyr 20 25 30
Giu Met lie Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Giu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Sex Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala G)u Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Giu Pro Leu Arg Phe Asp Asn Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 298 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 298
Giu Val Gin Leu Leu Giu Ser Arg Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Aig Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Giu His 20 25 30
Giu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Giu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -166- 163920-序列表.doc 201245225
Lys Gly Arg Phe Ser Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 299 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 299
Glu Val Gin Pro Leu Glu Ser Gly Gly (Jly Leu Val Gin Pro GJy Gly 1 5 Ί0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30
Glu Met He Trp Val Arg Gin Ala Fro (}ly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Ήιγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ?0 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 300 <211> 116 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 300
Glu Val Gin Leu Leu Glu Ser Ala Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Tyr 20 25 30 -167- 163920-序列表.doc 201245225
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Fhe Asp Tyr Trp Gly Gin Gty Ala Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 301 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 301
Glu Val Gin Leu Leu Glu Pro Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30
Glu Met He Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Asn Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <2I0> 302 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 •168- 163920·序列表.doc 201245225 <400> 302
Glu Val Gin Leu Leu Glu Ser Gly Gly ijly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Oly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp \sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Leu Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Ser Gly Gin Gly Thr Leu Val Thr Va] Ser Ser 115 120 <210> 303 <211> 123 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 303
Glu Glu Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val
Sei Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Ala Thr Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 -169- 163920·序列表.doc 201245225 <210> 304 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 304
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Va] 35 40 45
Ser Gly He Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Phe Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Gly Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 305 <21I> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 305
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly He Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 •170·
163920·序列表.doc 201245225
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Asn 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val iler Asn 115 120 <210> 306 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 306
Glu Val Gin Ixu l^u Glu Ser Gly Gly (ily Leu Val Gin Pro Gly Gly 1 5 ].0 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser (ily Phe Thr Phe Asn Thr Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val
Ser Gly lie Gly Arg Arg Gly Phe Thr r.hr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ylsn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val Tyr Tyr Cys 85 !)0 95
Ala Lys Glu Pro lie Thr Tyr Asp Leu 八rg Tyr Ala Arg Phe Asp Tyr 100 105 110
Ser Gly Gin Gly Thr Lea Val Thr Val ；5er Ser 115 120 <210> 307 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 307
Glu Val Gin Leu Met Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser I^eu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Va] Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Tyr Thr Thr Tyr Tyr Ala Asp Ser Val -171 - 163920-序列表.doc 201245225 50 55 60
Lys G)y Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 308 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 308
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ala Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg His Gly Phe Thr Thr Tyr TyT Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro He Thr Tyr Asp Met Arg Tyr Ala Arg Ser Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 309 <211> 123 <212> PRT <213>人工序列 <220〉 <223>人工序列之描述：合成多肽 <400> 309
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 •172· 163920-序列表 _doc 201245225
Scr Leu Arg Leu Ser Cys Tlir Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro (jly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp 八sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Thr Ala Val 了yr Phe Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Aig Ser Asp Tyr 100 105 110
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> 310 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 310
Glu Val Gin Leu Leu Glu Ser Gly Giy Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser G\y Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Tip Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp \sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Ser Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Ser Gly Leu Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 311 <21i> 123 <212> PRT <2】3>人工序列 -173· 163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 31】
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Ser Gly Gin Gly Thr Leu Val Thr Val Ser Ser 315 120 <210> 312 <2Π> ]23 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 312
Giu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly He Ser Arg His Gly Phe Thr Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110 -174·
163920-序列表.doc 201245225
Trp Gly Gin Gly Thr Leu Val Thr Val Ser Scr 115 120 <210> 313 <211> 123 <212> PRT <2L3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 313
Glu Val Gin Leu Phe Glu Ser Gly Gly 31y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser 31y Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Scr Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyc 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 314 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 314
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Uu Tyr 65 70 75 80 -175- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <2i0> 315 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 315
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Ser Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Asn Met Tyr 20 25 30
Glu Met Ser Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr 100 105 110
Trp Gly Gin Gly Thr L«u Val Thr Val Ser Gly 115 120 <2i0> 316 <211> 123 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 316
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr 20 25 30
Glu Met Scr Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 -176-
163920·序列表.doc 201245225
Ser Gly lie Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Va! 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp i^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro lie Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr loo 105 no
Trp Gly Gin Gly Thr Leu Val Thr Val -5cr Ser 115 120 <210> 317 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 317
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser jly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro jly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp A.sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu A.sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 318 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 318
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly •177· 163920·序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 319 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 319
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thi Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Thr Lys Leu Pro Phe lie Phe Glu Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 320 <211> 116 •178- 163920·序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 320
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly. Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thi Val Ser Ser 115 <210> 321 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 321
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Set Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val -179- 163920-序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 322 <2ll> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 322
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Tyr Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe lie Phe Asp Asn Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 323 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 323
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 •180· 163920·序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp 八sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ser Val Tyr His Cys 85 90 95
Ala Lys Pro Pro Phe He Phe Gly Asp 7rp Gly Pro Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 324 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 324 Glu Val Gin Leu Leu Glu Ser Gly Gly (31y Leu Val Gin Pro Gly Gly 10 15
Ser Arg Arg Leu Ser Cys Ala Ala Ser iJly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Oly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg ΊΤιγ Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Ήιγ Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 325 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 325
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 】 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 • 181 - 163920·序列表.doc 201245225
Glu Met Trp Trp Val Axg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 326 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 326
Glu Va] Gin Leu Leu Glu Ser Gly Gly Gly Leu Va! Gin Pro Gly GJy 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Vai Leu Glu Arg Val 35 40 45 .
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 327 <211> 116 <212> m <213>人工序列 <220> <223>人工序列之描述：合成多肽 -182-
163920-序列表.doc 201245225 <400> 327
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Uu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 328 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 328
Giu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu lie Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Scr Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Leu Lys Leu Pro Phe I]e Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 -183- 163920-序列表.doc 201245225 <210> 329 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 329 GJu Val Gin Leu Leu G)u Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Ήιγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr His Cys 85 90 95
Thr Lys Leu Pro Phe lie Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 330 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 330
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Met Val Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp ITir Ala Val Tyr Tyr Cys 85 90 95 •184·
163920·序列表.doc 201245225
Ala Lys Leu Pro Phe Phe Phe Asp Ser ^rg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 331 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 331
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 332 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 332
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Axg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val -185- 163920-序列表.doc 201245225 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 333 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 333
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Tyr Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 310
Thr Val Ser Ser 115 <210> 334 <211> 116 <212> PRT <2】3>人工序列 <22Q> <223>人工序列之描述：合成多肽 <400> 334
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -186· 163920·序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Val Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 335 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 335
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210〉 336 <211> 116 <212> PRT <2]3>人工序列 •187· 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 336
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Thr Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 337 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 337
Glu Val Gin Leu Leu Glu Sex Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Leu Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110 -188 -
163920-序列表.doc 201245225
Thr Val Ser Ser 115 <210> 338 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 338
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Sci Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Prc Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Asp Asp Thr Ala Val Tyr His Cys 85 90 95
Thr Lys Leu Pro Phe lie Phe Glu Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 339 <211> 116 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 339
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu.Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Ser kxg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 •189· 163920·序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Ser Trp Gly Gin Gly TbT Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 340 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 340
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Set Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 341 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 341
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45 •190·
163920-序列表.doc 201245225
Ser Ala lie A.sn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala GIu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 342 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 342
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly ] 5 10 15
Ser Leu Arg Leu Sex Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Giu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Vai 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 343 <211> 116 <2\2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 343
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly -191 - 163920-序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu G3n Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 ]10
Thr Val Ser Ser 115 <210> 344 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 344
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Leu Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 345 <211> 116 -192-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <m> 345
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Leu Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 346 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 346
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Phe Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val •193- 163920-序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 347 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 347
Glu Vai Gin Leu Leu GIu Ser Gly Gly Gly Leu Val Gin Pro G)y Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phc Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Phe Aig Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Aig Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 348 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 348
Glu Val Gin Leu Leu Glu Ser Gly Gly G]y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 •194· 163920-序列表.doc 201245225
Met Gly Arg Phe Thr lie Scr Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 !)0 95
Ala Lys Leu Pro Phe Thr Phc Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 349 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 349
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg rhr Tyr Tyr Ala Asp Ser Val 50 55 60
Met Gly Arg Phc Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 350 <21L> 116 <212> m <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 350
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 -195- 163920-序列表.doc 201245225
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Cly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Thr Tyr Phe Ser Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 11.5 <210> 351 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <40〇> 351
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Phe Phe Glu Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 352 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -196-
163920-序列表.doc 201245225 <400> 352
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn· Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Thr Tyr Phe Lys Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser L15 <210> 353 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 353
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Tht Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Ser Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 -197- 163920-序列表.doc 201245225 <210> 354 <21l> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 354
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Tlir Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Asn 115 <210> 355 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述·合成多肽 <400> 355
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 】0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Oir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 •198·
163920·序列表.doc 201245225
Ala Lys Leu Pro Phe Pro Phe Ser Glu Ττρ Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 356 <211> 116 <2i2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 356
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser i^u Arg Leu Ser Cys Ala Ala Ser Gly Phe Ήιγ Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Aia Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Ihr Leu Tyr 65 70 75 80
Leu Gin Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ?0 95
Ala Lys Leu Pro Phe Tyr Phe Ser Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 357 <211> 116 <212> PRT <213>人工序列 <220> <2幻> 人工序列之描述：合成多肽 <400> 357
Glu Val Gin Leu Leu Glu Ser Gly Gly 31y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Tyr Gly Asn Leu Thr Tyr Tyr Ala Asp Ser Val •199- 163920-序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 358 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 358
Glu Val Gin Leu Lea Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Set Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Giy Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Pro Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Tin Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 359 <211> 116 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 359
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -200· 163920·序列表 _doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phc Thr Phc Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phc Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 360 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 360
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Met Gly Gly Phe Thr l^yr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phc Thr 11c Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe rrhr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 361 <211> 116 <212> PRT <213>人工序列 •201 - 163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 361
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 362 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 362
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Arg Gly Gin Gly Thr Leu Val 100 105 110 •202·
163920·序列表.doc 201245225
Thr Val Ser Ser 115 <210> 363 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 363
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly I^eu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro His Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 364 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 364
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Ala Gly Arg Leu Thr Tyr Tyx Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr I^u Tyr 65 70 75 80 -203 - 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr TyT Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <21Q> 365 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400〉 365
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Vai Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg AJa Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 366 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 366
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45 -204-
163920-序列表.doc 201245225
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 367 <211> 116 <212> PRT <213>人工序列 <220>
<223>人工序列之描述：合成多肽 <400> 367
Glu Val Gin Leu Leu Glu Ser Gly Gly GLy Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Phe Thr Phe Pro Pro Val 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg TTir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 368 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 368
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly -205· 163920-序列表.doc 201245225 15 】0 】5
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Hie Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr A]a Val Tyr 丁yr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 369 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 369
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Tbr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Asn His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 AJa Lys Leu Pro Phe Thr Phe Glu Asp 丁rp Gly G]n Gly Thi Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 370 <2U> 116 •206-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <2；23>人工序列之描述：合成多肽 <400> 370
Glu Val Gin Leu Lea Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro His Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp 丁rp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 371 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 371
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Fro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Arg Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Pro Gly Met Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Niet Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val -207- 163920·序列表.doc 201245225 100 105 1)0
Thr Val Ser Scr 115 <210> 372 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 372
Glu Val Gin Leu Leu Glu Ser Gly Gly Giy Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gin Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 373 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 373
Glu Val Gin Leu Uu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 •208-
163920-序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp 八sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Hir Ala Val Tyr Tyr Cys 85 !K) 95
Ala Lys Leu Pro Phe Thr Phc Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 374 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 374
Glu Val Gin Leu Leu Glu Ser Gly Gly ijly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp .^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 375 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 375
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 •209- 163920-序列表.doc 201245225
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Tlir Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 376 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 376
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe ΊΉγ Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 4S
Ser Ala lie Asn Pro Ser Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 377 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -210-
163920-序列表.doc 201245225 <400> 377
Glu Val Gin Leu Leu Gla Ser Gly Gly Gly Leu Val Gin Pro G]y Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Tyr Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Scr 115 <210> 378 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 378
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 . 40 45
Ser Ala He Asn Pro Trp Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 •211 · 163920-序列表.doc 201245225 <210> 379 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 379
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Vai Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val. Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 380 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 380
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1. 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser His Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 SO
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Tlir Ala Val Tyr Tyr Cys 85 90 95 •212·
163920·序列表.doc 201245225
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Glu Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 381 <21!> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 38!
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro ijly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ?0 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 382 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 382
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 35
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Asn Gly Arg Leu Thr Tyr Tyr Ala Asp Ser Val -213· 163920-序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Ala Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 383 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 383
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gin Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly TTir Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 384 <211> 116 <212> PRT <2】3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 384
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 10 15 •214-
163920-序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro His Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gtn Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Uu Val 100 105 110
Thr Val Ser Scr 115
<2I0> 385 <21l> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 385
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Ala Gly Met Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Π5 <210> 386 <211> 116 <212> PRT <213>人工序列 -215- 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 386
Glu Val G)n Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro His Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Vat Ser Ser 115 <210> 387 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 387
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met A.sn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110 -216-
163920·序列表.doc 201245225
Thr Val Ser Ser 115 <210> 388 <2L1> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 388
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr I^eu Val 100 105 110
Thr Val Ser Ser 115 <210> 389 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 389
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Ala Gly Phe Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -217- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 390 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 390
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg AJa Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 391 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 391
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45 -218·
163920-序列表.doc 201245225
Ser Ala lie Asn Pro Trp Gly Gly Phe Thr Tyr Tyt Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 392 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 392
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ^sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 393 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 393
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly •219- 163920-序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Set Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 394 <211> 116 <212> PRT <213>人工序列 <220> <2U>人工序列之描述：合成多肽 <400> 394
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro G]y Gly l 5 10 】5
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 395 <211> 116 •220·
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 395
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 396 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 396
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Tyr Gly Asn Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val -221 · 163920-序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 397 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 397
Glu Va] Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Va] Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro His Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va] Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Sex Ser 115 <210> 398 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 398
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Ala Gly Phe Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 163920-序列表.doc 201245225
Lys Gly Arg Phe Thr He Ser Arg Asd Asn Scr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp As]) Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 399 <211> 116 <212> PRT <2i3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 399
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 2S 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Ala Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 400 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 400
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Giy Gly 15 10 15
Ser Leu Arg Leu vSer Cys Ala Ala Ser Gly Phe Ala Phe Arg Asp Tyr 20 25 30 .223 - 163920-序列表.doc 201245225
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro His Gly Ser Leu Hir Tyr Tyr Ala Asp Ser Va] 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 401 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 401
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Va! Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 402 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 •224-
163920-序列表.doc 201245225 <400> 402
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Prc Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Trp Phe Thr Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <230> 403 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 403
Glu Val Gin Leu Leu Glu Ser Gly Giy Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Tip Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Met Phe Ser Asp Arg Gly Gin Gly Thr Leu Val LOO 105 110
Thr Val Ser Ser 115 •225 - 163920·序列表.doc 201245225 <210> 404 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述•合成多肽 <400> 404
Glu Va] Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg I-eu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Leu Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 405 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <40Q> 405
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 •226-
163920·序列表.doc 201245225
Ala Lys Leu Pro Hu Arg Phc Glu Asp Trp Gly Gin Gly Thr Leu Val 100 305 110
Thr Val Ser Ser 115 <210> 406 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 406
Glu Val Gin l-eu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 .75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 407 <211> 116 <232> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 407
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala Tie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val -227- 163920·序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Scr 115 <210> 408 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 408
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys leu Pro Thr Phe Phe Lys Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 409 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 409
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 •228 ·
163920·序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Phe Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 410 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 410
Glu Val Gin Leu Leu Glu Ser Gly Gly jly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser jly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro jly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Ihr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu \sp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Gin Leu Phe His Asp ^rg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210〉 411 <21I> 116 <212> PRT <2]3>人工序列 •229· 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 411
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Gin Leu Phe Giu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 412 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 412
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Phe Gly Phe Ser Glu Trp Gly Gin Gly Thr Leu Val 100 105 110 -230-
163920·序列表.doc 201245225
Thr Val Ser Ser 115 <210> 413 <2L1> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 413
Glu Val Gin Leu Leu Glu Ser Gly Gly 3Iy Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser 31y Phe ITir Phc Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin G】y Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Gin Leu Phe Gin Asp Tip Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 414 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 414
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Aig Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 -231 - 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Giu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Phe Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 415 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 415
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro His Tyr Phe Lys Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 416 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 416
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Ser Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45 -232-
163920-序列表.doc 201245225
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp hsn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Glu Glu Trp Gly Gin Giy Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210〉 417 <211> 116 <212> PRT <213>人工序列 <220>
<223>人工序列之描述：合成多肽 <4D0> 417
Glu Val Gin Leu Leu Glu Ser Gly Gly (ILy Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro (fly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg I.Tir Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 !)〇 95
Ala Lys Leu Pro Phe Arg Phe Ser Asp 八rg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 418 <211> 116 <212> m <213>人工序列 <220>
<223>人工序列之描述：合成多肽 <400> 41S
Glu Val Gin Leu Leu Giu Ser Gly Gly ijly Leu Val Gin Pro Gly Gly - 233 - 163920·序列表.doc 201245225 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Tbr Phe Arg Asp Tyt 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Thr Leu Phe Gin Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 419 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 419
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Ser Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Asn 115 <210> 420 <211> 116 •234-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 420 G)u Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Scr Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Trp Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 421 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 421
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Ττρ Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Tyr 80
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr Leu Val -235 · 163920-序列表.doc 201245225 100 105 110
Thr Val Ser Ser 115 <210> 422 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 422
Glu Va] Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Asn 115, <210> 423 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 423
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Vai Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -236- 163920·序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 424 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 424
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Lau Val Gin Pro Gly Gly
! 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala Ite Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Lea Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Phe Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Scr 115 <210> 425 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 425
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 .237· 163920-序列表.doc 201245225
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu GIu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Fhe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Phe Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110 TTir Val Scr Ser 115 <210> 426 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 426
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser I^eu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 427 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -238 -
163920-序列表.doc 201245225 <400> 427
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Giu.Met Trp Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu ksp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Asn 115 <2]0> 428 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400〉 428
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser 31y Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro 31y Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Phe rhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 -239- 163920·序列表.doc 201245225 <210> 429 <213> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 429
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys A]a Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Phe Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 430 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 430
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp 丁rp Val Arg Gin A]a Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 -240-
163920-序列表.doc 201245225
Ala Lys Leu Pro Phe Phe Phe His Glu Trp G3y Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 431 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 431
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Scr Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val
Ser Ala lie Asn Pro Trp Gly Gly Leu llir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Giy Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 432 <211> 1L6 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 432
Glu Val Gin Leu Leu Glu Ser Gly Gly (Sly Len Val Gin Pro Gly Gly 1 5 ：l0 15
Scr Leu Arg Leu Ser Cys Ala Ala Ser (51y Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro (51y Lys Gly Leu Glu Arg Val 35 40 45
Ser Ata lie Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val -241 - 163920·序列表.doc 201245225 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Va! Tyr His Cys 85 90 95
Ala Ly$ Leu Pro Met Phe Phe Glu Asp Trp Gly G]n Gly Thr Leu Val 100 105 110
Thr Val Ser Asn 115 <210> 433 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 433
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu 丁rp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 434 <2]]> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 434
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 •242·
163920·序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro (51y Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Leu r.rhr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu 八sp Tlu Ala Val Tyr Tyr Cys 85 W 95
Ala Lys Leu Pro Phe Phe Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 435 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 435
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp ^sn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Phe Phe His Glu Trp Gly Gin Gly Thr Lea Val 100 105 110
Thr Val Ser Ser 115 <210> 436 <211> 116 <212> PRT <213>人工序列 -243- 163920-序列表.doc 201245225 <22Q> <223>人工序列之描述：合成多肽 <400> 436
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Mel Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 437 <211> 119 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 437
Glu Val Gin Leu Leu Glu Thr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser I^eu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30
His Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Met lie Asp Ala Asp Gly Leu Gly Thr Tyr Tyr Ala Asp Pro Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Lys Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Pro Gly Pro Gin Phe Gly Gin Phe Asp Tyr Leu Gly Gin Gly 100 105 ]10 •244·
163920·序列表.doc 201245225
Thr Leu Va〗Thr Val Ser Ser 115 <2!0> 438 <211> 119 <212> PRT <2lj>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 438
Glu Val Gin Leu Phe Glu Ser Gly Gly Gly Uu Val Gin Thr Gly Gly 15 L0 15
Ser Leu Arg Lew Ser Cys Ala Ala Ser (31y Phe Thr Phe Ser Thr Tyr 20 25 30
His Mel Gin Trp Val Arg Gin Ala Pro (：ly Lys Gly Leu Glu Trp Val 35 40 45
Ser Met lie Asp Ala Asp Gly Leu Gly >s Tyr Tyr Ala Asp'Pro Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ?0 95
Val Lys Fro Gly Pro Gin Phe Gly Gin Tyr Asp Tyr Trp Gly Gin Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> 439 <211> 121 <212> PRT <213>人工序列 <220〉 <223>人工序列之描述：合成多肽 <400> 439
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Scr Gly Tyr 20 25 30
Asp Met Gin Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser Ala Ser Gly Val Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn rYhx Leu Tyr 65 70 75 80 -245- 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Tyr Pro Asn Arg Phe Ala Leu Asn Ser Phe Asp Tyr Arg Gly 100 105 110
Arg Gly "Hir Leu Val Thr Val Ser Ser 115 120 <210> 440 <211> 121 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇〇> 440
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30
Asp Met Gin Trp Val Arg Gin Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45
Ser Thr lie Ser Ala Ser Gly Val Tyr Thr Tyr Tyr Thr Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Thr Lys Tyr Pro Asn Arg Phe Ala Arg Asn Asn Phe Asp Tyr Trp Gly 100 105 110
Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 441 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 441
Asp lie Leu Met TTir Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Glu Ala Pro Lys Leu Leu lie 35 40 45 • 246-
163920-序列表,doc 201245225
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Ser Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 442 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 442
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
Asp Arg Val Thr 11c Thr Cys Arg Ala Asp Scr Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 443 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 443
Asp lie Gin Met Thr Val Scr Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asp Scr Scr lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Ixu Leu lie -247, 163920-序列表.doc 201245225 35 40 45 GIu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 444 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇〇> 444
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Asp Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 445 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 445
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30 -248-
163920-序列表.doc 201245225
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Thr Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser G]y 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly S5 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 446 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 446
Asp lie Gin Met Thr Val Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Scr Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 447 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 447
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asp Ser Ser lie Leu Trp Ala 20 25 30 -249- 163920-序列表.doc 201245225
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe TTir Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Asp Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 448 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 448
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Glu Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 449 <211> 10S <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <40Q> 449
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Aig Ala Asn Ser Ser lie Leu Trp Ala 20 25 30 •250-
163920·序列表.doc 201245225
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val ijln Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Va) Glu Asn Lys Arg 100 105 <210> 450 <211> 108 <212> PRT <213>人工序列 <220>
<223>人工序列之描述：合成多肽 <400> 450
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Scr lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Scr Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Scr Gly 50 55 60
Ser Gly Scr Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val '31η Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 451 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 451
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Scr Ala Ser Val Giy 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Scr lie Leu Trp Ala -251 - 163920-序列表.doc 201245225 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly lie Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Giy Thr Asp Phe Thr Leu Tbr lie Ser Scr Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Cly Gin Gly Thr Lys Val Giu lie Lys Arg 100 105 <210> 452 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 452
Asp He Gin Met Thr Gin Ser Pro Ser Scr Leu Ser Ala Ser Val Gly 15 10 15 •Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 453 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 453
Asp lie Leu Leu Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15 252 ·
163920-序列表.doc 201245225
Asp Arg Val Thr lie Tbr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Lea Gin Ser Gly Val Pro Ser Arg Phc Scr Gly 50 55 60
Ser Gly Scr Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phc Ala Thr Tyr Tyr Cys Val (31n Asn Ala Val Tip Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu [le Lys Arg 100 105
<210> 454 <21i> 108 <212> PRT <213:>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇〇> 454 Asp lie Gin Met Thr Gin Ser Pro Ser ;3er Leu Ser Ala Ser Val Gly 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly ^al Pro Ser Arg Phc Ser Gly 50 55 60
Ser Gly Thr Gly Thr Asp Phe Thr Leu Thr He Ser Gly Leu Gin Fro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val 31n Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Asp Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 455 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 455 Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 10 15 163920·序列表.doc 253 - 5 201245225
Asp Arg Val Thr lie Pro Cys Arg Ala Asn Ser Ser lie Leu Trp Ala 20 25 30
Leu Ala Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Glu Ser Ser Ser Gly Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gin Asn Ala Val Trp Pro Gly 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 456 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 456
Asp He Gin Met Ala Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Vai Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Ala Scr Pro Pro Leu 85 90 95
Thr Leu Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 457 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇0> 457
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15 •254.
163920-序列表.doc 201245225
Asp Ser Val Thr He Thr Cys Arg Ala ,5er Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly i]lu Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Fhe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Ala Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Asn Val Glu lie Lys Arg 100 105
<210> 458 <211> 108 <212> PRT <2I3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 458
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Ala Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 459 <21l> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 459
Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly -255 · 163920-序列表.doc 201245225 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg ΊΤιγ lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Ars Leu Gin Ser Gly Val Pro Ser Arg Phe Sex Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 460 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 460
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Glu Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr He Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Scr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 SO
Glu Asp Ser Ala Thr Tyr Tyr Cys His Gin Tyr Ala Ser Pro Pro Leu 85 90 95
Thr Leu Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 461 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 461 .256. 163920·序列表.doc 201245225
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 】5
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Set Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Ala Ser Pro Pro Leu 85 90 95
Thr Leu Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105
<210> 462 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 462
Asp lie Gin lie Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Asp Pro Lys Uu Leu lie 35 40 45
Tyr Leu Ala Scr Arg Leu Gin Ser Gly Val Pro Scr Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 463 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -257- 163920-序列表.doc 201245225 <400> 4-63
Asp lie Gla Met Tlir Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Glu Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Trp 100 105 <210> 464 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 464
Asp lie Gin Leu Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu Tie 35 40 45 .
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu He Lys Arg 100 105 <210> 465 <211> 108 <212> PRT <2I3>人工序列 <220> <223>人工序列之描述：合成多肽 •258·
163920-序列表.doc 201245225 <400> 465
Asp He Gin Met Ser Gin Ser Pro Ser ihr Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr L'cu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Met Phe Gly Gin Gly Thr Lys Val Glu He Lys Arg 100 105
<210> 466 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 466
Asp lie Gin Met Thr Gin Ser Pro Ser ；5er Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala ,5er Gin Thr He Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly ：-ys Asp Pro Lys Leu Leu He 35 40 45
Tyr Leu Ala Scr Arg Leu Gin Scr Gly Val Pro Ser Arg Pbc Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His ijln Tyr Glu Ser Pro Pro Leu 85 W 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 467 <211> 108 <212> PRT . <213>人工序列 <220> <223>人工序列之描述：合成多肽 -259- 163920-序列表.doc 201245225 <400> 467
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr He Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu G!n Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr fie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Fro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu 11c Lys Arg 100 105 <210> 468 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 468
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Phe Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45 .
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 列 序 98T 工， 4610PR人 0>1>2>3> <21<21<21<21 <220> 163920-序列表.doc -260· 201245225 <223>人工序列之描述：合成多肽 <400> 469
Asp lie Gin Met Thr Gin Tyi Pro Ser Ser Leu Ser Ala Ser Val Gly 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Ser lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Glu Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phc Scr Gly 50 55 60
Ser Gly Scr Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 470 <211> 108 <212> PRT <213>人工序列 <220> * <223>人工序列之描述：合成多肽 <400> 470
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Scr Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Pro Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 471 <211> 108 <212> PRT <213>人工序列 •261 - 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 471
Asp lie Gin Met Thr Gin Scr Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser Gin Ala lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Scr Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Ala Ser Pro Pro Leu 85 90 95
Thr Leu Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 472 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 472
Asn lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Ala lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Tyr Leu Ala Scr Arg Leu Gin Ser Gly Val Pro Ser ATg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 473 <21I> 108 <212> PRT <213>人工序列 -262-
163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 473
Asp lie Gin Met Tlir Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Scr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Scr Gly 50 55 60
Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 474 <231> 108 <212> PRT <2】3>人工序列 <220〉 <223>人工序列之描述：合成多肽 <400> 474
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr He Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Scr Arg Phe Scr Gly 50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His 31n Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105
<210> 475 <211> 108 <212> PRT •263 - 163920-序列表.doc 201245225 <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 475
Asp lie Gin Met Thr Gin Thr Pro Ser Ser Leu Scr Ala Scr Val Gly 15 10 15
Asp Ars Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Glu Ala Pro Lys Leu Leu He 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thi Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Lys He Lys Arg 100 105 <210> 476 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 476
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Ser Val Thr He Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Ίήτ Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 305 <210> 477 <211> 108 -264-
163920-序列表.doc 201245225 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 477
His lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Are 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phc Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Lea Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Tlir Lys Val Glu lie Lys Arg 100 105 <210> 478 <211> 108 <212> PRT <213>人工序列 <220> ' <223>人工序列之描述：合成多肽 <400> 478
Asp Val Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Glu Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Thr Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Ala Ser Pro Pro f^cu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 479 •265 - 163920-序列表.doc 201245225 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 479
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Aig Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75. 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Val lie Lys Arg 100 105 <210> 480 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 480
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Are Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 •266·
163920·序列表.doc 201245225 <210> 481 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 481
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Scr Val Gly 1 5 ：:0 IS
Asp Arg Val Thr lie TTir Cys Arg Ala 3er Gin Pro lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly l.ys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu ΊΤη lie Ser Ser Leu Gin Pro
65 70 75 80 GIu Asp Phe Ala Thr Tyr Tyr Cys His (?ln Tyr Glu Set Pro Pro Leu 85 ')0 95
Thr Phe Gly Gin Gly Thr Lys Val Glu Me Lys Arg 100 105 <210> 482 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 482
Asp lie Gin Met Thr Gin Ser Pro Ser 5er Leu Ser Ala Ser Val Giy 1.5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Scr Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 -267- 163920-序列表.doc 201245225 <210> 483 <211> 108 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 483
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Ser lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu He lie Arg 100 105 <210> 484 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 484
Asp lie Gin Met Ήιγ Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Lea Asn Trp Tyr Gin Gin Lys Pro Gly Lys Aia Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Fro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys krg 100 105 •268-
163920-序列表.doc 201245225 <210> 4g5 <2Π> 108 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 485
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser Gin Ser lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Tyr Leu Ala Ser Arg Leu Gin Ser Gly Va) Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu S5 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 486 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4-00> 486
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Phe Glu His Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Vai Glu lie Lys Arg •269· 163920·序列表.doc 201245225 100 105 <210> 487 <2Π> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 487
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Phe Pro lie Asp Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala 丁hr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr E^e Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 488 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 488
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Ser Thr He Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95 •270.
163920-序列表.doc 201245225
Thr Phe Gly Gin Gly Thr Lys Val GIu Ac Lys Arg 100 105 <210> 489 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 489
Asp lie Gin Met Thr Gin Ser Pro Ser i!er Leu Ser Ala Ser Val Gly 15 ]〇 15
Asp Arg Val Thr lie Thr Cys Arg Ala iler Ser Gin lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
丁yr Leu Ala Ώπ Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pto Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 490 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 490
Asp lie Gin Met Thr Gin Ser Pro Ser Ser I,cu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala 5：er Glu Arg lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly \'al Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu llir He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 95 -271 · 163920-序列表.doc 201245225
Thr Phe Gly Gin GJy frhr Lys Val Glu lie Lys Arg 100 105 <210> 491 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 491
Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Gin lie Gly Arg Arg 20 25 30
Leu Asn Tip Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Scr Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 492 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 492
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Pro lie Ala Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Scr Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95 -272·
163920-序列表.doc 201245225
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 493 <2il> 108 <212> m <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 493
Asp lie Gin Met Thr Gin Ser Fro Ser !5er Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala ；5er Gly Asn lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu I]e 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Scr Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Scr Ser Uu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His (Hn Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu ile Lys Arg 100 105 <210> 494 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 494
Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly ] 5 10 15
Asp Arg Val frhr lie Thr Cys Arg Ala ；ser Arg Asn Ile Asp Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu •273· 163920·序列表.doc 201245225 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu He Lys Arg 100 105 <210> 495 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 495
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Ser lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 496 <211> 108 <2I2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 496
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Asn lie Gly Thr Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80 •274·
163920-序列表.doc 201245225
Glu Asp Phe Ala Thr Tyr Tyr Cys His (iln Tyr Glu Ser Pro Pro Leu 85 <)〇 95
Thr Phe Gly Gin Gly Thr Lys Val Glu ：；le Lys Arg 100 105 <210> 497 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 497
Asp lie Gin Met Thr Gin Ser Pro Ser ；>er Leu Ser Ala Ser Val Gly 1 5 :.0 15
Asp Arg Va) Thr He Thr Cys Arg Ala llci Glu Val lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu A】a Thr Arg Leu Gin Ser Gly Ya] Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu ΊΉγ lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 ')0 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 498 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇〇> 498
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Glu Ala lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80 -275 - 163920-序列表.doc 201245225
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 499 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 499
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Thr Ser lie Ala Arg Arg 20 25 30
Leu Asn Tip Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Scr Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 500 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 500
Asp lie G!n Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Leu Asn lie Gly Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie 35 40 45
Tyr Leu Ala Thr Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80 -276-
163920·序列表.doc 201245225
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 501 <211> 108 <212> FRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 501
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Thr lie Glu Arg Arg 20 25 30
Leu Asn Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Arg Leu Leu lie
Tyr Leu SeT Ser Lys Ixu Gin Ser Gly Val Pto Ser Arg Phe Scr Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Scr Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cvs His Gin Tyr Glu Ser Pro Pro Leu 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 502 <21I> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400〉 502
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala SeT Gly Ser Thr He Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala Tie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr .277- 163920-序列表.doc 201245225 65 70 75 80
Leu GJn Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 503 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 503
Glu Val Gin Pro Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Scr Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg lie 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 300 305 110
Thr Val Ser Ser 115 <210> 504 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 504
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Ser Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Ser Thr Phe Ala Gly Tyr 20 25 30 •278· 163920-序列表.doc 201245225
Glu Met Trp Ttp Yal Arg Gin Ala Pro (Uy Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser ITir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 % 95
Ala Arg Asp Pro Tyr Ser Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Set Val Ser Ser 115
<210> 505 <211> 116 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 505
Glu Val Gin Leu Leu Glu Ser Gly Gly (ily Leu Val Gin Pro Gly Gly 1 5 ).0 15
Ser Leu Arg Leu Ser Cys Ala Ala Sct (lly Leu Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro (Hy Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Πγ Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 !)〇 95
Ala Arg Asp Pro Tyt Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 506 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 163920-序列表.doc -279- c： 201245225 <400> 506
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Sex Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Scr Ser 115 <210> 507 <211> 116 <212> PRT <2Π>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 507
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Val Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 •280-
163920-序列表.doc 201245225 <210> 508 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 508
Glu Val Gin Leu Leu Glu Ser Gly Gly (ily Leu Val Gin Pro Gly Gly 1 5 :0 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser (ily Ser Thr lie Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro (ily Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Scr Gly Ser Gly Gly Ser 'l.'hr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phc Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 % 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Gly Gin Gly Thr Pro Val 100 105 110
Thr Val Ser Ser 115 <210> 509 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 509
Glu Val Gin Leu Met Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Tyr Arg Gin Ala Pro (Jly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Arg Ser 'Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ?0 95 -281 - 163920-序列表.doc 201245225
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Va] Ser Ser 115 <210> 510 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 510
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe ΊΉγ lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 300 105 110
Thr Val Ser Ser 115 <210> 511 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 511
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr lie Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 •282 ·
163920·序列表.doc 201245225
Lys Gly Arg Phe Ήιτ lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 ζ'Ο 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Irp Gly Gin Gly Thr Leu Val 100 . 105 110
Thr Val Ser Ser 115 <210> 512 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 512
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Scr (fly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Ser Gly Ser Gly Gly Ser Ί.Ιιγ Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp 八sp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 W 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 】05 110
Ser Val Scr Ser 115 <210> 513 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 513
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr lie Ala Gly Tyr -283 - 163920-序列表.doc 201245225 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg AJa Glu Asp Thr Ala Va] Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 514 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 514
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Scr Gly Phe PFhr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Scr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Thr Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 515 <211> 116 <212> PRT <213>人工序列 <220> •284-
163920-序列表.doc 201245225 <223>人工序列之描述：合成多肽 <400> 515
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Phe Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asp Thr Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Arg Gin Gly Tlir Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 516 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 516
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr 20 25 30
Glu Val Ττρ Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Fro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Uu Val 100 105 110
Thr Val Ser Ser -285 - 163920·序列表.doc 115 201245225 <210> 517 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 517
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg He 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Lys Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 518 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 518
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Me Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80 •286· 163920-序列表.doc 201245225
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 519 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 519
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ala Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu GJn Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 520 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 520
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Scr Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Leu Trp Tip Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45 •287- 163920·序列表.doc 201245225
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 521 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 521
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Phe Thr Leu Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys S5 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 522 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 522
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -288·
163920·序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210〉 523 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 523
Glu Val Gin Leu Leu Glu Ser Gly Gly 31y Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser jly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Scr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<210> 524 <211> 116 <212> PRT -289- 163920-序列表.doc 201245225 <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 524
Glu Val Gin Pro Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 525 <211> 116 <212> PRT <2I3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 525
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met 丁rp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Scr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Scr Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Ser Trp Gly Gin Gly Thr Leu Val 100 105 110 -290-
163920·序列表.doc 201245225
Thr Val Ser Ser 115 <210> 526 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 526
Glu Ala Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 IS
Set Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu frhr Phc Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 527 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 527
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Scr Gly Gly Scr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phc Scr lie Ser Arg Asp Asp Scr Lys Asn Thr Uu Tyr -291 - 163920-序列表.doc 201245225 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp His Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 528 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 528
Glu Val ό】η Leu Leu G]u Ser G]y Gly Gly Leu Val Gin Pro G]y Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys S5 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 529 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 529
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30 -292·
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Glu Met Trp Trp Phe Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phc Thr lie Scr Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn 丁rp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115
<2I0> 530 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 530
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Glu Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Lea Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp His Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 531 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -293 - 163920-序列表.doc 201245225 <400> 531
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ala Gly Tyr 20 25 30
Glu Met Tip Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp His Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 532 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 532
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ue Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 -294-
163920·序列表.doc 201245225 <210> 533 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 533
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Phe Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Scr Lys Asn Thr Leu Tyr
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 534 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 534
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 -295- 163920·序列表.doc 201245225
Ala Ly$ Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 535 <211> 116 <2t2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 535
Glu Va] Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phc Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn Trp Gly Gin Gly Thr Leu Va) 100 105 110
Thr Val Ser Ser 115 <210> 536 <2U> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400〉 536
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 -296-
163920-序列表.doc 201245225
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <2L0> 537 <2U> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 537
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe AJa Gly Tyr 20 25 30
Glu Met Trp Trp Phe Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 538 <211> 116 <212> PRT <2I3>人工序列 <220> <2；Z3>人工序列之描述：合成多肽 <400> 538
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr •297- 163920-序列表.doc 201245225 20 25 30
Glu Leu Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Scr Gly Scr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 539 <211> Π6 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 539
Glu Val 01n Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30
Glu Leu Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala I)e Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Arg Asp Pro Tyr Scr Phe Asp Tyi Trp Gly Gin Gly Thr I-eu Val 100 105 110
Thr Val Ser Ser 115 <210> 540 <211> 120 <212> PRT <213>人工序列 <220> •298· 163920-序列表.doc 201245225 <223>人工序列之描述：合成多肽 <400> 540
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Leu Trp Va! Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser He Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Scr Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 541 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 541
Glu Val Gin Leu Leu Val Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser I^eu Arg Leu Ser Cys Ala Ala Scr Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Leu Trp Val Arg Gin Ala Pro Gly Lys Gly Pro Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp vSer Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asti Scr Lys Asn Thr l^u Tyr 65 70 75 80
Leu Gin Met Asn Set Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser •299- 163920-序列表.doc 201245225 115 120 <210> 542 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 542
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ήιγ Phe Pro Thr A】a 20 25 30
Glu Met Val Trp Val Arg Lys Ala Pro Gly Met Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly Giy Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Ala Leu Val Thr Val Thr Ser 115 120 <210> 543 <211> 120 <212> PRT <213>人工序列 <220> <223:>人工序列之描述：合成多肽 <400> 543
Glu Val Gin Leu Leu Val Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Val Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Ser He Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80 -300-
163920·序列表.doc 201245225
Leu Gla Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly His 100 105 110
Gly Ala Leu Val Thr Val Ser Ser 115 120 <210> 544 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 544
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Fhe Thr Phe Pro Thr Ala
Glu Met Lea Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Aig Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Scr Ser 115 120
<210> 545 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 545
Glu Ala Gin I^eu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Scr Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Val· Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp lie 35 40 45 •301 - 163920-序列表.doc 201245225
Ser Ser lie Scr Ala Ser Gly Gly Ser Thr Tyr Tyr AJa Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Arg 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 546 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 546
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Leu Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly G】y Ser Tlir Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Pro 100 .105 110
Gly Ala Leu Val Thr Val Ser Ser 115 120 <210> 547 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 547
Glu Val Gin Leu Leu Glu Scr Gly Gly Gly Lea Val Gin Pro Gly Gly 15 10 15 •302-
163920-序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Leu Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Val Ser Ser
<210> 548 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 548
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro ITir Ala 20 25 30
Glu Met Leu Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Tip Val 35 40 45
Ser Ser lie Ser Ala Scr Gly Gly Scr Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Pro 100 105 110
Gly Ala Leu Val Thr Va] Ser Ser 1)5 120
<210> 549 <211> 120 <212> PRT •303 · 163920-序列表.doc 201245225 <213>人工序列 <220〉 <223>人工序列之描述：合成多肽 <400> 549
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Leu Trp Va] Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Tyr Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 550 <211> 120 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 550
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 J5
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala 20 25 30
Glu Met Leu Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser lie Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gin loo 105 no •304·
163920·序列表.doc 201245225
Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 551 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 551
Asn lie Gin Met Thr Gin Ser Pro Ser ；5er Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala !>er His Phe lie Gly Thr Leu 20 25 30
Leu Thr Trp Tyr Gin His Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (Πη Gly Val Leu Trp Pro Ala 85 !)0 95
Thr Phe Gly Gin Gly Thr Lys Val Glu ile Lys Arg 100 105 <210> 552 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 552
Asp Ile Gin Met Thr Gin Ser Pro Ser !>er Leu Ser Ala Sex Val Gly 15 [0 15
Asp Arg Val Thr Ile Thr Cys Arg Ala ：>er His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Arg Lys Ala Pro Lys Leu Leu Ile 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Scr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu frhr lie Ser Ser Leu His Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro -305 - 163920·序列表.doc 201245225 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 553 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 553
Asp lie Gin Met Thr Gin Ser Pro Ser Scr Leu Thr Ala Ser Val Gly 15 10 15
Asp Arg Va】Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly ITir Lys Val Glu Asn lie Arg 100 105 <210> 554 <21i> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 554
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Ala Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Lea lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80 -306· 163920·序列表.doc 201245225
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 555 <2il> 108 <2L2> PRT <21.3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 555
Asp lie Gin Met Thr Gin Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Ala Thr I^u 20 25 30
Leu Set Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu He
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ήιγ lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 556 <211> 108 <212> PRT <213>人工序列 <220>
<2M>人工序列之描述：合成多肽 <400> 556
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Thr Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80 •307· 163920·序列表.doc 201245225
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 557 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 557
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin His Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu He Lys Arg 100 105 <210> 558 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 558
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe -lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin His Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser G]y Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80 -308-
163920-序列表.doc 201245225
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (Jin Gly Val Leu Trp Pro Ala 85 !>0 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 559 <213> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 559
Asp lie Gin Met Thr Gin Ser Pro Ser ：>er Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin His Lys Pro Gly l.ys Ala Pro Lys Leu Leu lie
Thr Tyr Gly Ser Met Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys G!y i31n Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu He Lys Arg ' 100 105 <210> 560 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 560
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin His Lys Pto Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr He Ser Ser Leu Gin Pro -309- 163920-序列表,doc 201245225 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 561 <211> 108 <2I2> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 561
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Thr Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin His Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 562 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 562
Asn lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Ίΐτ Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Scr Trp Tyr Gin His Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 •310·
163920-序列表.doc 201245225
Ser Gly Ser Gly Thr Asp Phe Thr Leu ΊΤιγ lie Ser Scr Leu Gin Fro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (iln Gly Val Leu Trp Pro Ala S5 90 95 TTir Phe Gly Gin Gly Thr Lys Val Glu He Lys Arg 100 105 <210> 563 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 563
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 :.0 15
Asp Arg Val Thr lie Asn Cys Arg Ala Ser His Phe lie Gly Thr Leu
Leu Ser Trp Tyr Gin His Lys Pro Gly l.ys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Giy Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly 55er Gly Thi Asp Phe Thr Leu *rhr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (31n Gly Val Leu Trp Pro Ala 85 ')0 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105
<210> 564 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 564
Asp lie Gin Leu Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 1.5
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Thr Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 •311 - 163920·序列表.doc 201245225
Scr Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 565 <213> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 565
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Tyr Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Val Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gty Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu He Lys Gin 100 105 <210> 566 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 566
Asp lie Gin Mel Thr Gin Ser Pro Ser Ser Leu Ser Ala Scr Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Arg Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Scr Gly Val Pro Ser Arg.Phe Ser Gly 50 55 60 -312-
163920-序列表.doc 201245225
Scr Gly Ser Gly ΤΗτ Asp Phe Thr Leu Ihr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 50 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 567 <211> 10S <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 567
Asp He Gin lie lie Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala S：er His Phe lie Gly Thr Leu
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 568 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 568
Asp lie Gin Met Thr Gin Scr Pro Ser iler Leu Ser Ala Ser Val Gly 15 ]〇 15 •Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly ^al Pro Ser Arg Phe Ser Gly 313· 163920·序列表.doc 201245225 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Scr Scr Leu Gin Pro 65 70 75 80 GIu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 569 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 569
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Trp Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu G]n Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu Asn Lys Arg 100 105 <210> 570 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <4〇0> 570
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp 丁yr Gin Leu Lys Pro G]y Lys Ala Pro Lys Leu Leu l]e 35 40 45 -314-
163920-序列表 _doc 201245225
Thr Tyr Giy Ser Leu Leu Gin Arg Gly Val Pro Ser Arg Phe Sex Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu llir lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (Πη Gly Val Leu Trp Pro Ala 85 <)〇 95
Thr Phe Gly Gin Gly Thr Lys Val Glu "le Lys Arg 100 105 <210> 571 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 571
Asp lie Gin Met Thr Gin Ala Pro Ser ；>er Leu Ser Ala Ser Val Gly
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly ΊΙιγ Leu 20 25 30
Leu Ser Trp Tyr Gin Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Sei Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu *rhr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (Πη Gly Val Leu Trp Pro Ala 85 !)0 95
Thr Phe Gly Gin Gly Thr Lys Val Glu Asn Lys Arg 100 105 <210> 572 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 572
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 35
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45 -315· 163920-序列表.doc 201245225
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Giy Thr Lys Val Glu lie Lys Arg 100 105 <210> 573 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 573
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 574 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 574
Asp lie Leu Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45 -316·
163920·序列表.doc 201245225
Thr Tyr Gly Ser Leu Leu Gin Sei Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu lie Ser Ser Leu Gin Pro 65 70 *75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly iiln Giy Val Leu Trp Pro Ala 85 \)0 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 57S <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 575
Asp lie Gin Met Thr Gin Ser Pro Ser 3cr Leu Ser Ala Set Val Gly
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe lie Gly Tlu Leu 20 25 30
Val Ser Trp Tyr Gin Gin Lys Pro Giy Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Scr Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Scr Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 30 95
Thr Tyr Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 576 <211> 108 <212> ?RT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 576
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Val Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie •317- 163920-序列表.doc 201245225 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu Asn Lys Arg 100 105 <210> 577 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 577
Asp lie Lys Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Val Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Met Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 578 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 578
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie ITu Cys Gin Ala Ser His Phe lie Gly Thr Leu 20 25 30 •318·
163920-序列表.doc 201245225
Val Ser Trp Tyr Gin Gin Lys Pro Gly L.ys Ala Pro Lys Leu Leu lie 3S 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ihr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Cln Gly Val Leu Trp Pro Ala S5 SO 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 579 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 579
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala i：er His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly l.ys Ala Pro Lys Leu Leu lie 35 40 .45
Thr Tyr Gly Ser Trp Leu Gin Ser Gly Xd.\ Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 % 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 580 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述··合成多肽 <400> 580
Asp lie Gin Met Thr Gin Ser Pro Ser i;er Leu Ser Ala Ser Va】Gly 1 5 :.0 15
Asp Arg Val Thr lie Thr Cys Arg Ala !!er His Phe lie Gly Thr Leu 20 25 30 -319- 163920·序列表.doc 201245225
Leu Ser Trp Tyr Gin Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Trp Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95 ITir Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 581 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 581
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly L 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Glu Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 582 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 582
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Ser lie Thr Cys Arg Ala Ser His Phe lie Gly Thr Leu 20 25 30 -320·
163920·序列表.doc 201245225
Leu Ser Trp Tyr Gin Glti Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly \al Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Phe Gly Thr Asp Phe Thr Leu Ihr lie Ser Ser Leu Q]n Pro 65 70 75 80
Glu Asp Leu Ala Thr Tyr Tyr Cys Gly Cln Glu Val Leu Trp Pro Ala 85 50 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 583 <211> 108 <212> PRT <213>人工序列 <220>
<223>人工序列之描述：合成多肽 <400> 583
Asp lie Gin Met Thr Gin Ser Pro Ser Set Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Gin Ala Σ-er His Phe lie Gly Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly \'al Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (Iln Glu Val Leu Trp Pro Ala 85 50 95
Thr Phe Gly Gin Gly Thr Lys Val Glu ]le Lys Arg 100 105 <210> 584 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 584
Asp lie Gin Met Thr Gin Ser Pro Ser iier Leu Ser Ala Ser Val Gly 1 5 ：10 15
Asp Arg Val Thr lie Thr Cys Arg Ala !>er His Phe lie Gly Thr Leu -321 - 163920-序列表.doc 201245225 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu I>eu He 35 40 45
Thr Tyr Gly Scr Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr lie Gly Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala i5 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 100 105 <210> 585 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 585
Asp lie Gin Met Tht Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe He Gly Thr Leu 20 25 30
Leu Scr Trp Tyr Gin Gin Lys Pro Gly Lys Ala Thr Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Pro 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu Tie Lys Arg 】00 105 <210> 586 <21i> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 586
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15 •322-
163920·序列表.doc 201245225
Asp Arg Val Thr lie Thr Cys Arg Ala Her His Phe He Ala Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu frhr I1e Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (；In Gly Val Leu Trp Pro Ala 85 !)0 95
Thr Phe Gly Gin Gly Thr Thr Val Glu (le Lys Arg 100 105
<210> 587 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 587
Asp lie Gin Met Thr Gin Ser Pro Ser .'5er Leu vSer Ala Ser Val Gly 15 10 15
Asp Arg Val Tlir lie Thr Cys Arg Ala ；5er His Phe lie Ala Gin Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly '/al Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Scr Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 31n Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu He Lys Arg 100 105 <210> 588 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 588
Asp lie Gin Met Thr Gin Ser Pro Scr Ser Leu Ser Ala Ser Val Gly 15 10 15 •323 - 163920·序列表.doc 201245225
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Ala Gin Leu 20 25 30
Leu Scr Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Arg Arg 100 105 <210> 5S9 <21I> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 589
Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Tyr lie Ala Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys I^eu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Ala Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 590 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 590
Asp He Gin Met Thr Gin Scr Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15 -324-
163920-序列表.doc 201245225
Asp Arg Val Thr lie Thr Cys Arg Ala -5cr His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly 二ys Ala Pro Lys Leu Leu lie 35 40 45
Thr Trp Ala Ser Tyr Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Scr Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly ijln Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu tie Lys Arg 100 105
<210> 591 <211> 108 <212> PRT <213>人工序列 <220〉 <M3>人工序列之描述··合成多肽 <400> 591
Asp lie Gin Met Thr Gin Ser Pro Ser ；5er Leu Ser Ala Scr Val Gly ] 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala ；3er His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Trp Thr Ser Tyr Leu Gin Ser Gly Val Pro Ser Arg Phe Scr Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu tie Lys Arg 100 105
<210> 592 <211> 108 <212> PRT 人工序列 <220> <223>人工序列之描述：合成多肽 <400> 592
Asp He Gin Met Thr Gin Ser Pro Ser 3er Leu Ser Ala Ser Val Gly -325- 163920-序列表.doc 201245225 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe He Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Trp Ser Ser Tyr Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu He Lys Arg 100 105 <210> 593 <211> 108 <212> PRT <213>人工序列 <220> <2M>人工序列之描述：合成多肽 <400> 593
Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Trp Gly Ser Trp Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 594 <211> 108 <212> PRT <2丨3>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 594 -326-
163920·序列表.doc 201245225
Asp lie Gin Met Thr Gin Ser Pro Ser Si:r Leu Scr Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala St;r His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lvs Ala Pro Lys Leu Leu lie 35 40 45
Thr Trp Ala Ser Trp Leu Gin Ser Gly Viil Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Tlir lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 9i) - 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105
<210> 595 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 595
Asp lie Gin Met Thr Gin Ser Pro Ser Ssr Leu Ser Ala Ser Val Gly 1 5 13 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ssr His Phe He Gly Ser Leu 20 25 30
Lea Ser Trp Tyr Gin Va) Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Trp Ser Ser Trp Leu Gin Scr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 596 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -327- 163920-序列表.doc 201245225 <400> 596
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Scr Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Trp lie Ala Gin Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Gtu lie Lys Arg 100 105 <210> 597 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 597
Asp lie Gin Met Thr Gin Ser Pro Ser Scr Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg A1a Ser His Phe lie Gly Ser Leu 20 25 30
Leu Arg Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Ti:p Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 598 <211> 108 <212> PRT <2]3>人工序列 <220> <223>人工序列之描述：合成多肽 - 328-
163920-序列表.doc 201245225 <400> 598
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly ) 5 10 15
Asp Arg Val Hir lie Thr Cys Arg Ala Ser His Arg lie Ala Gin Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phc Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phc Thr Leu frhr lie Ser Scr Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (;ln Gly Va] Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu ile Lys Arg 100 105
<210> 599 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 599
Asp Ile Gin Met Thr Gin Ser Pro Ser !>er Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala !>er His Tyr He Ala Ser Lea 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly iys Ala Pro Lys Leu Leu Ile 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phc Scr Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu ffhr Ile Scr Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly (iln Gly Val Leu Trp Pro Ala 85 W 95
Iht Phe Gly Gin Gly Thr Oir Val Glu He Lys Arg 100 105 <210> 600 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 -329- 163920-序列表.doc 201245225 <400> 600
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Set Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Arg Phe Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <2i0> 601 <2il> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 601
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe He Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Lys Ser Tyr Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 602 <211> 108 <212> PRT <213>人工序列 <220> -330-
163920-序列表.doc 201245225 <223>人工序列之描述：合成多肽 <400> 602
Asp lie Gin Met Thr Gin Ser Pro Ser Ker Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val TTir lie Thr Cys Arg Ala iler His Phe lie Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly L.ys Ala Pro Lys Leu Leu lie 35 40 45
Thr Trp Gly Ser Tyr Leu Gin Ser Gly Val Pro Ser Arg Phe Scr Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 SO 95
Thr Phe Gly Gin Gly Thr Thr Val Glu He Lys Arg 100 105 <210> 603 <211> 108 <212> PRT <213>人工序列 <220> <2乃> 人工序列之描述：合成多肽 <400> 603
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe He Trp Gly Pro 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ihr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Ser Ala Thr Tyr Tyr Cys Gly C:ln Gly Val Leu Trp Pto Ala 85 SO 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 604 <211> 108 <212> PRT <213>人工序列 -331 - 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 604
Asp lie Gin Met Thr Gin Scr Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Trp lie Ala Thr Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45 l*hr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg m 105 <21Q> 605 <211> 108 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 605
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser His Phe lie Trp Gly Pro 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phe Scr Gly 50 55 60
Ser Gly Ser Gly Tlir Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210> 606 <211> 108 <212> PRT <213>人工序列 •332·
163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 606
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Set Ala Ser Val Gly 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe lie Gly Ser Leu 20 25 30
Leu Asn Trp Tyr Gin Val Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Thr Tyr Gly Ser Leu Leu Gin Ser Gly Val Pro Ser Arg Phc Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gin Gly Val Leu Trp Pro Ala 85 90 95
Thr Phe Gly Gin Gly Thr Thr Val Glu lie Lys Arg 100 105 <210〉 607 <21L> 108 <212> m <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 607
Gly lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser His Phe He Gly Ser Leu 20 25 30
Leu Ser Trp Tyr Gin Val Lys Pro Gly L.ys Ala Pro Lys Leu Leu He
Thr Tyr Gly Ser Trp I-eu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ihr tie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly C：ln Gly Val Leu Trp Pro Ala 85 i'O 95
Thr Phe Gly Gin Gly Thr Thr Val Glu He Lys Arg 100 105
<210> 608 <211> 348 <212> DNA • 333 - 163920-序列表.doc 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 608 gaggtgcagc tcctgtgcag ccassgaagg gcagactccg ctgcaaatga ttttactttc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac igaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac accgcggtat atiactgigc gaaacttccg aggagtgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348 <210> 609 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 609 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc <210> 610 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 348 <400> 610 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gggtattttg tgttggagtc tgggggaggc ttgetacagc ctggggggtc cctgcgtctc cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac tgaaag£ccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt actactgggg tcagggaacc clggtcaccg tctcgagc 60 120 180 240 300 348 列 序 18A工 6134¾人 <220> <223>人工序列之描述：合成聚核苷酸 163920·序列表.doc -334- 201245225 <400> 61〗 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gag^aggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggcctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat 240 ctgcaaaiga acagcctgcg tgccgaggat acc.jcgglat attactgtgc gaaagagccg 300 tttcgttttg actactgggg tcagggaacc ctg.?tcaccg tctcgagc 348 <210> 612 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 612
gaggtgcagc tgttggagtc tgggggaggc ttg；jtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgggta at£gtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcc<:gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acc：icggtat attactgtgc gaaagagccg 300 cttaggtttg actactgggg tcagggaacc ctg：jtcaccg tctcgagc 348 <210> 613 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 613
gaggtgcagc tgttgeagtc tgggggaggc ttg；>tacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat acc：scggtat attactgtgc gaaagagccg 300 attacgtatg ctatgaggta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 614 <211> 348 <212> l^A <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 614 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 163920·序列表.doc -335- 201245225 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttatttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 615 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 615 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcic 60 tcctgtgcag cctccggatt caccttttcg acttatcata tgcagtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaatg att£atgcgg atggtcttgg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300 ccgcagtttg gtcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 616 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 616 gaggtgcagc 丨gttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag ctlccggatt caccttttcg gggtatgata tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attagtgcgt cgggtgtttt tacatactac 380 gcagactccg tgaagggccg gttcaccacc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attact£tgc gaaatatcct 300 aatcgttttg cgcttaataa ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 age 363
<210> 617 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 617 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gategagagt tcttccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 163920·序列表.doc -336- 300 201245225 gaagattttg ctacgtacta ctgtgttcag aatjjcgggtt ggcctggtac gttcggccaa gggaccaagg tggaaatcaa acgg <210> 618 <211> 324 <212> DMA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 618 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagai tic.ictctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag taticgagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg <210> 619 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 324 60 120 180 240 300 324
<400> 619 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaat£a tatagttttg tgttggagtc cctccggatt gtctagagcg tgaagggccg acagcctgcg actactgggg tgggggaggc cacctttgct ggtctcagct gttcaccatc tgccgaggat tcagggaacc ttggtacagc gggtatgaga attagtggta tcccgcgacg accgcggtat ctggtcaccg ctggggggtc tgtggtgggt gtggtggtag attocaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct cacatactac cacgctgtat gaaagatcct 60 120 180 240 300 348
<210> 620 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 620 gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttccg actgctgaga tggtgtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc iacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg t£ccgaggac acc£cggtat attactgtgc gaaagagccg gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 163920·序列表.doc 60 120 180 240 300 360 -337- 201245225 <21Q> 621 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 621 gacatccaga tgacccagtc tccatcctcc ctgtctgcal ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgtiat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtg£tcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 622 <211> 357 <212> MW <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 622
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg aagaatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagafitg ggtctcagcg attgagtcgg atggtcaggc tacatactac 180 gcagactccg tgaagg£ccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgctgaggac accgcggtat attactgtgc gaaaaatcgg 300 attcctgatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 623 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 623
gaggtgcagc cgttggagtc tggm^ggc ttggtacagc ctseggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gctggggcta tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgataagg agggictgtc tacataotac 180 gcagactccg tgaasggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atiactgtgc gaaaggtagg 300 attcctgggc tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <21Q> 624 <211> 357 <212> DNA <2】3>人工序列 <220〉 163920·序列表.doc 338 · 201245225 <223>人工序列之描述：合成聚核苷酸 <400> 624 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gatgcggcga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg attcagccta igggtgatgg tacatactac 180 gcagactccg tgaagggccg gttcaccgtc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga aca£cct£cg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300 attcctactc ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 625 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 625
gaggtgcagc tgttggagtc tgggggaggc ttg£；tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gatlcgccta tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct att£.cttcga atggttatga gacatactac 180 gcagactccg tgaagggccg- gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac ac〇i：cggtat attactgtgc gaaagggcgt 300 attcctactc ttcattttga ctactggggt cagiigaaccc tggtcaccgt ctcgagc 357 <210> 626 <211> 357 <212> I>NA <2I3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 626
gaggtgcagc tgttggagtc tgggggaggc ttgjitacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gagcatgata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attjjgtccgg atggttttca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acc：>cggtat attactgtgc gaaagggcgt 300 attcctactc ttcattttga ctactggggt cag^gaaccc tggtcaccgt ctcgagc 357 <210> 627 <211> 357 <2)2> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 627 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 163920·序列表.doc •339· 201245225 tcctgtgcag cctccggatt cacctttggt gagtatcata tgtcttgggt ccgccaggct 120 ccagggaa££ gtctagagtg ggtctcaagg attactcctc ttggtacgct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactglgc gaaagggcgt 300 attccttcgc ttacgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 628 <211> 357 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 628 gagstgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctstgcag cctccggatt cacctttggt acgaatgcga tgagttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagg atttcgccgg gtggtgatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtgt attactgtgc gaaagggcgt 300 gttccggatc tgctttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 629 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 629 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctuccg tctgaggaga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg atttcggctg atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaagggcgt 300 gttccggatc tgctttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 630 <211> 357 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 630 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggSStc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct sassat£ata tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgcggug atgstgatcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920·序列表.doc •340· 201245225 ctgcaaatga acagcctgcg tgccgaggac acciicggtat attactgtgc gaaaggtaag gttccgtctc ttcattttga ctactggggt cagj：gaaccc tggtcaccgt ctcgagc <210> 631 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 631 gaggtgcagc tgttggagtc tgggggaggc ttgitacagc ctgggggatc cctgcgtctc tcctgtgcag cctccggatt cacctttagg acgi.tggata tgtctlgggt ccgccaggct ccagggaagg gtctagagtg ggtctcacgt atti.cgggtg atggtatgaa tacatactac gcagaclccg tgaagggccg gttcaccatc tccc：gc£aca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccggggac acciicggtat attactgtgc gaaaggggtg actccggatt tgacttttga ctactggggt cagiigaaccc tggtcaccgt ctcgagc
<210> 632 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 632 gaggtgcagc tgttggagtc tgggggaggc ttgfitacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgag cgtf：atgata tgacgtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcacgt attitatgctg ggggtgtgca tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acascctgcg tgccgaggat acc$：cggtat attactgtgc gaaaggggtg actccggatt tgacttttga ctactggggt cagngaaccc tggtcaccgt ctcgagc <210> 633 <211> 3S7 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 633 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga actccggatt tgttggagtc cctccggatt gtctagagtg tgaasggccg acagcctgcg tgactlttga tgggggaggc cacctttgat ggtctcacgg gttcaccatc tgccgaggac ctactggggt ttgutacagc gatjjattcta att tcgagtg tccogcgaca accucggtat cagugaaccc
Ctggg£ggtC tgacgtgggt atggtgcgag attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaaggggtg ctcgagc <210> 634 163920·序列表.doc -341 - 201245225 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 634 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gaggaggata tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgatagtg ttggtgaggg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgag£ac accgcggtat attactgtgc gaaaggggtg 300 actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 635 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 635
gaggtgcagc tgttggagtc tgggsgaggc ttggtacagc ctggmgtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gattcggcga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg att^ataatc ctggtcagca tacatactac ISO gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtact 300 gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 636 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 636 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg cagcatagta tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgatggtg ggggttataa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggag 300 gttcctcgtc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 637 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc -342- 201245225 <400> 637 gaggtgcagc tgttggagtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt cagg;agccta tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg att£；cgtata atggtggtga tacatactac 180 gcagactccg igaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accs：cggtat attactgtgc gaaagggatt 3〇〇 actcctaatt tgacttttga ctactggggt cag^gaaccc tggtcaccgt ctcgagc 357 <210> 638 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 638
gaggtgcagc tgttggagtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgt£cag cctccggatt cacctttgag aatiatccga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attiiatgcta cgggttctat tacatactac i8〇 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accucggtat attactgtgc gaaaggggtt 300 attcctcatt tgatgtttga ctactggggt cagj；gaaccc tggtcaccgt ctcgagc 357 <210> 639 <211> 357 <212> ΚΊΑ <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 639 gaggtgcagc tgttggagtc tgggggaggc ttg；jtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt gattatgata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attictggta ctggtaatag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaggggtg 300 gtgccgtatc ttgcttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 640 <211> 357 <212> DNA <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 640 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccUtgag gctgatgcga tgacgtgggt ccgccaggct 120 -343- 163920·序列表.doc 201245225 ccagggaagg gtctagagtg ggtctcaagg attaatgtgg atggtgatcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300 gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 641 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 641 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat cgggcggata tgacgtgggt ccgccaggct 120. ccagggaagg gtctagagtg ggtctcaagg atttcggggg agggtaagtg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatg 300 gttcctaatt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 642 <211> 357 <212> DNA <^3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 642 gaggtgcagc tgttggagtc tg^gggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat tgggagccga tgtcttgggt ccgccaggct 120 ccggggaagg gtctagagtg ggtctcacet attaattctt ctggttggga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatg 300 gttcctaatt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 643 <211> 357 <212> DNA <213>人工序列 <22Q> <223>人工序列之描述：合成聚核苷酸
<400> 643 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gatgagccga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attcctcctg agggtgctcc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaa£aa cacgctgtat 240 ctgcaaatga acagcctgcg igccgaggac accgcggtat attactgtgc gaaagggatt 300 163920-序列表.doc -344- 201245225 actcctaatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 644 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 644 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt cacctttcat ccagggaagg gtctagagtg ggtctcacgt gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac gtgccggatc tgcattttga ctactggggt ttggtacagc ctggggggtc cctgcgtctc aatcatgata tgtcttgggt ccgccaggct attagtcggg gtggtcttca gacatactac tcccgcgaca attccaagaa cacgctgtat accfcggtat attactstgc gaaagggatt cagggaaccc tggtcaccgt ctcgagc 60 120 180 240 300 357
<210> 645 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 645 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga attccggcta tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc cctccggatt cacctttaat gagtatccta tgtcgtgggt ccgccaggct gtctagagtg ggtctcacgt atts.atgggg atggtgctaa tacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac accr.cggtat atiactgtgc gaaagggatt tgcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 60 120 180 240 300 357
<210> 646 <211> 357 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 646 fiaggtgcagc tgttggagtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttggg gatutgccta tgtcgtggfit ccgccafigct ccagggaagg gtctagagtg ggtctcaagg att；ratcctt atggttctaa tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac acc^cggtat attactgtgc gaaaggtact atgcctagtc ttacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 60 120 】80 240 300 357 <210> 647 <211> 357 163920·序列表.doc 345 _ 201245225 <212> m <2丨3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 647 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg gattatgata tgtcttgggt ccgccaggct 120 ccagggaagg fitctagagtg ggtctcacgt atttcggcgc ttggtgctac tacatactac 180 gcagactccg tgaagggccg gitcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcag 300 cttccggcgt tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 648 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 648 gaggtgcagc tgttggagtc tgggggQggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccittaag cgttattata tgacttgggt ccgccaggct 120 ccagggaagg atctagagt^ ggtctcaggt attgttcctt ctggtaatag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtagg 300 attccggatc tgcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 649 <211> 366 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 649 gaggtgcagc tgttfigagtc tgegggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gattatgata tgacttgggt ccgccaggct 120 ccagggaagg gtctagagig ggtctcaagg atttctccga cgggtgggca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccsaggac accgcggtai attactgtgc gaaaggtgtt 300 attccgtatt tgtctttttc tccgtttgac lactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 650 <211> 366 <212> DNA <213>人工序列 <22Q>
163920-序列表.doc 346- 201245225 <223>人工序列之描述：合成聚核苷酸 <400> 650 gaggtgcagc tgttggagtc tgggggaggc ttgi>tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct aagtaitgga tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg att]；attcgc atggtgct£g tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgtcgaggac accj^cggtat attactgtgc gaaaggtgct 300 cctaagttta tgactacgta tacgtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 651 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
gaggtgcagc tgttggagtc tgggggaggc ttg：.：tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttttg tcttatccga tgcattgggt ccgccaggct 120 ccag£gaagg gtctagagtg ggtctcatcg att：^attcga ggggttcggt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tccogcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accijcggtat attactgtgc gaaaggtcat 300 agttggacgt ttgactactg gggtcaggga acc«Hggtca ccgtctcgag c 351 <210> 652 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 652 gaggtgcagc tgttggagtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg aatigtaata tgactigggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attaalccgg atggtgggtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggcgt 300 attcctactc ttcattuea ctactggggt cagggaaccc tggicaccgt ctcgagc 357 <2)0> 653 <211> 357 <212> ΟΊΑ <2】3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 653 -347- 163920-序列表.d〇c 201245225 gaggtgcagc tgttggastc tgggggaggc ttggtacagc ctsgggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg ccgaggagga tgggttgggt ccgccaggct 120 ccagggaagg gtctaga^tg ggtctcatcg attgatgata ttggtcgtag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaggggcg 300 cagggtgtgt tsttgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 654 <211> 351 <212> DNA β1%、工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 654 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gattatagga tggtttgggt ccgccaggct 120 ccagg^aagg gtctagagtg ggtctcatcg atttctactt ctggtgagct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaacggcg 300 ggtca£tttt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 655 <21l> 348 <212> DNA <213>人工序列 <220><223>人工序列之摇述：合成聚核苷酸 <400> 655 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg gagtatgaga tggtttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcagcg atttcgcgtg agggtcgggc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctscaaatga acaacctgcg tgccgaggat accgcggtat attactgtgc gaaagagcct 300 gttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 656 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 656 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg acttatgaga tgctttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttcttctt ctggtaatta tacatactac 180 163920·序列表.doc •348· 201245225 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acogcggtat attactgtgc gaaagagccg 300 ctgatgtttg actactgggg tcagggaacc ctj；gtcaccg tctcgagc 348 <210> 657 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 657
gaggtgcagc tgtlggagtc 〖gggggaggc tti〖gtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aci;gaggaga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg auagtccta atggtgcttt tacattctac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagcct 300 attctgtttg actactgggg tcagggaacc ctiigtcaccg tctcgagc 348 <210> 658 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 658 gagglgcagc tcctgtgcag ccagggaggg gcagactccg ctgcaaatga agtcgtattt tgtt2gagtc tgggggaggQ ttf：gtacagc ctggggggtc cctgcgtctc cctccggatt caccittggt canatgata tggtttgggt ccgccaggct gtctagagtg ggtctcaact ati:aatggtg ctggtctgaa tacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaagtgct ttgactactg gggtcaggga accctggtca ccgtctcgag c 60 120 180 240 300 351
<210> 659 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 659 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga actcatattt tgttggaEtc tgggggaggc cctccggatt cacctttagg gtctagagtg ggtctcatct tgaagggccg gttcaccatc acagcctgcg tgccgaggac ttgactactg gggtcaggga ttiigtacagc ctggggggtc cctgcgtctc agrtatgaga tggcgtgggt ccgccaggct atr.agtactc tgggtacgaa gacatactac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gcaatcttct accctggtca ccgtctcgag c 60 120 180 240 300 351 •349. 163920-序列表.doc 201245225 <210> 660 <2Π> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 660 gaggtgcagc tgttgsastc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggact cacctttatt aggtatgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttcgtcgt ctggttggac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaagtgat 300 gctcatattt tigactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 661 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 661 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctsgmgtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttat gcttatgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttcggatg atggtacgcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatctg 300 gggcaggggt ttgactactg sgstcaggga accctggtca ccgtctcgag c 351 <210> 662 <21!> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 662 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gatcatggga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attggtccgt ctggtgaggc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcgt 300 attcctaatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 663 <2I1> 348 <212> Wk <213>人工序列 163920-序列表.doc 350- 201245225 <220> <223>人工序列之描述 合成聚核苷酣 <400> 663 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tctgauttg tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 cctccggatt cacctttgag tcicaggata tgtcttgggt ccgccaggct 120 glctagagtg ggtctcaggt atiagtccga atggttggga tacatactac 180 tgHagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatagg 300 actactgggg tcagggaacc ctg;gtcaccg tctcgagc 348 <210> 664 <211> 351 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 664 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga cctaagggtt tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 cctccggatt cacctttggg gattatgata tgtggtgggt ccgccaggct 120 gtctagagtg ggtctcaagg attcetcatc cgggtggtgt tacatactac 180 tsaagggccg gticaccatc tcccgcgaca attccaagaa cacgctgtat 240 acagcctgcg tgccga£gac accgcggtat attactgtgc gaaagctgtt 300 ttgactacig gggtcaggga accctggtca ccgtctcgag c 351 <210> 665 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醆 60 120 180 240 300 357 <400> 665 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga attcctaatt tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg tggasittga tgggggaggc cacctttcgg ggtctcatct gttcaccatc tgccgaggat ctactggggt ttggtacagc gtttattgga attgatccgc tctcgcgaca accgcggtat cagggaaccc ctggggggtc tgacttgggt ^SiStgggat attccaagaa attactgtgc tsgtcaccgt cctgcgtctc ccgccaggct gacatactac cacgctgtat gaaagcgcgt ctcgagc <210> 666 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 666 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggagtc cctgcgtctc -351 - 163920-序列表.doc 201245225 tcctgtgcag cctccggatt cacctttagt gcttatgata tgacgtgggt ccgccaggct 120 ccagggaagg gtcttgagtg ggtctcacgt attaatccga cgggttctta tacalactac 180 gcagactccg tgaagggcc^ sttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagctaag 300 attccgaatt tggttlttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 667 <211> 363 <212> \m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 667 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg gatagtgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgcgcata atggtgggca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctggt 300 catcctcagc agactgaggc ttttgactac tggggtcage gaaccctggt caccgtctcg 360 age 363
<210> 668 <21l> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 668 gagatgeage tgttggagtc tmss^gge ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct aettatgata tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaag atttctccga atggttggag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacatcag 300 acgcattttg actactgggg tcagggaacc ctggtcaccg tetegage 348
<210> 669 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 669 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gtttatgata tgaggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttettett cgggtacgta tacatactac 180 163920-序列表.d〇c •352· 201245225 gcagactccg tgaagggccg gttcaccatc tcccgc^aca atrccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acci；cggtat attactgtgc gaaaiatcct 300 aagaattttg actactgggg tcagggaacc ctgiitcaccg tctcgagc 348 <210> 670 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 670
gaggtgcagc tgttggagtc tgggggaggc ttgr,tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct catjiaggata igacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attngtccga atggttggga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acq：cggtat attactgtgc gaaacgtact 300 aggagtaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 671 <211> 360 <212> DKA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 671 gaggtgcagc tgttggagtc tgggggaggc ttgj；tacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgag aagi：atatta tgggttgggc ccgccaggct ccagggaagg gtctagagtg ggtctcaacg att^actatt ggggtcagca tacatactac gcagactccg tgaagggccg gttcactatc tcccgcgaca auccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accifc^gtat attactgtgc ganacgtagt catcttattc ctctgcagtt tgactactEg ggtoagggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360
<210> 672 <211> 369 <212> DNA <2i3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 672 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt caccttttct ccagggaagg stctggagtg £gtctcaacg gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac ctgcgggggg aggcgtttac ggagcgtttt ttg：jtacagc ctggggggtc ccigcgtcic gattatgcga tggggtgggt ccgccaggct atttcgtatg tgggttatta tacatactac tcccgcgaca attccaagaa cacgctgtat accicggtat attactgtgc gaaaaaggct gactactggg gtcagggaac cctggtcacc 60 120 180 240 300 360 163920-序列表.doc -353 - 201245225 gtctcgagc 369 <210> .673 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 673 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt ccgtatatga tgcattsggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgaggtta atggtaatag gacatactac 180 gcagactccg tgaaggiccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatgggtt 300 ggttcgaaga cgtcgtcgga taagagtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 674 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 674 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggic cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt acgacggaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcaagt attggtagtg ctggtgcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgcigtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaitggt 300 ggscatcctc agggicagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 675 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 675 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt cacctttcct agggagtgga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attcagccta tgggtcagac tacatactac ISO gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcegtat attactgtgc gaaataitct 300 cggaataagg ggltttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 163920-序列表.doc •354· 201245225 <210> 676 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 676 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tctaattggg igUggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg agacttttga tgeesgaggc cacctttacg ggtctcatct gttcaccatc tgccgaggat ctactggggt ttgi；tacagc agtnagtata attcagaggt tcccgcgaca acci：cggtat cagi：gaaccc ctggggggtc tgggitgggt atggtagtac attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct gacatactac cacgctgtat gaaacatgag ctcgagc 60 120 180 240 300 357 <210> 677 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 677 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga ggtcggggtt gtctcgagc tgttggagtc tgggggaggc ttg丨:tacagc ctggggggtc cctgcgtctc cctccggatt caccttttcg gtg:atagta tgcagtgggt ccgccaggct gtctagagtg ggtctcagcg attactccta atggtactcg gacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac acc^cggtat attactgtgc gaaaactctt cttatcctgg tgttgatttt gactactggg gtcagggaac cctggtcacc 60 120 180 240 300 360 369 <2)0> 678 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 678 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggsggtc cctgcgtctc tcctgtgcag cctccggatt cacctttccg agttatgcta tgacgtgggt ccgccaggct ccagggaagg gtctggagtg ggtctcacgt attacggcgg atggtactgt tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggttct attccgatgc ttacgtttga ctactggggt cagggaaccc tgfitcaccgt ctcgagc 60 120 180 240 300 <210> 679 <211> 360 <212> DNA <213>人工序列 163920-序列表,doc -355- 357 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 679 gaggtgcagc tgttg£a£tc tgggggaggc ttgsiacagc ctggggggtc cctgcglctc 60 tcctgtgcag cctccggatt caccttttcg acttatgata tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct atttctccta atggtactgg tatatactac 180 gcagactccg tgaagggccg gucaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaatcag 300 agtgttcatc atgctgtttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 680 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 680 gaggtgcagc tsctggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag aattatgaga tgacgtgg£t ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgcgccgc atggtcggct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtcag 300 altccgatgc ttgattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 681 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 681 saggtgcagc tgttggagtc tgeggsaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg cattatatga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttctcatt ttggtgatat tacatactac 180 gcagactccg tgaagggccg gucaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaatgat 300 atggtgatga agaatggggg gtttgactac tggggtcagg gaaccct-ggt caccgtctcg 360 age 363
<210> 682 <211> 357 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920·序列表.d〇c _356· 201245225 <400> 682 gaggtgcagc tgttggagtc tgggggaggc ttgjjtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag agg'：atgata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attijattcgc ggggttggtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acci：cggtat attactgtgc gaaagggttg 300 gtgccgcatc tgaggtttga ctactggggt cagjigaaccc tggtcaccgt ctcgagc 357 <210> 683 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 683
gaggtgcagc tgttggagtc tgggggaggc ttgjEtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg aatj：cgcaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagts ggtctcaagg atti：atgcta tgggtgatgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accjjcggtat attactgtgc gaaaggtaag 300 Sttccgagta ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 684 <231> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 684
gaggtgcagc tgttggagtc tgggggaggc ttgijtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg aat：icgcaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg att；>atgcta tgggtgatgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat acc；?cggtat attactgtgc gaaaggtgtt 300 attccggcgt ttgactactg gggtcaggga acc:tggtca ccgtctcgag c 351 <210> 685 <211> 354 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 685 gaggtgcagc 〖gttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag aatgatcgga tgcattgggt ccgccaggct 120 163920-序列表.doc -357- 201245225 ccagg$aagg gtctagagtg ggtctcatcg atttctgcta ctggtggtga tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcgglat attactgtgc gaaacagacg ggtacgaatc gttltgacta ctggggtcag ggaaccctgg tcaccgtctc gage 180 240 300 354 <210> 686 <211> 357 <212> mk <233>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 686 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttaat cagccttata tgtcgtgggt ccgccaggct ccagggaagg gtctggagtg ggtctcatct attgatgett cgggtggtac tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac geegeggtat attactgt^c gaaagatcst attcctaatc ttgtgttlga ctactggggt cagggaaccc tggtcaccgt ctcgagc 60 120 180 240 300
<210> 687 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 687 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgat aatgagaata tgacttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcacgt attgatggtg ggggttataa tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcag gttcctgagc tgctgtttga ctactggggt cagggaaccc tggtcaccgt cccgagc 60 120 180 240 300 357 <210> 688 <211> 357 <212> WA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 688 gaggtgcagc tgttmstc tgggggaggc tcctgtgcag cctccggatt cacctttgtt ccagggaagg gcctagagtg ggtctcagct gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgeesasgae ttggtacagc ctggggggtc cctgcgtctc testegaata tgacttgggt ccgccaggct attagtggta gtggtggtag cacatactat tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gaaaggtcgg 60 120 】80 240 300 163920-序列表.doc -358- 201245225 attcctacgt tggtgtttga ctactggggt ca^ggaaccc tggtcaccgt cicgagc 3S7 <210> 689 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酞 <400> 689 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt caccttlgtt ccagggaagg gtctagaglg ggtctcagct gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac attcctaatc ttgtgtttga ctactggggt ttf；gtacagc ciggggggtc cctgcgtctc tcjitcgaata tgacttgggt ccgccaggct atiagtggta gtggtggtag cacatactat tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gaaagatcgt caiggaaccc tggtcaccgt ctcgagc 60 120 180 240 300 357
<210> 690 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 690 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt caccttttct gatgattcga tgagttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcacgt. attaatgatg ctggtagttc tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact attcctcttc tggagtitga ctactggggt cagggaaccc tggtcaccgt ctcgagc 60 120 180 240 300 357
<210> 691 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 691 gagatgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgtt tcggatacta tgagttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcacgt attgatggga ctggtggtga tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccggggac accgcggtat attactgtgc gaaagggctt attcctgatc ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 60 120 180 240 300 357
<210> 692 <211> 357 <212> DNA 163920·序列表.doc -359· 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 692 gaggtgcagc tgttggagtc tggggsaggc ttgstacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gaggaggaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attattggtg gtggtcatga gacatactac 180 gcagadccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attaclfitgc gaaaggtact 300 attcctcttc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 693 <211> 357 <212> m <213>人工序列 <22Q> <223>人工序列之描述：合成聚核苷酸 <400> 693
gaggtgcagc tgttggagtc tggggsaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatgagaata tgacttgggt ccgccaggct 120 ccagggaagg atctagagtg ggtctcacgg attactgaga ggggtgatgt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300 gttcctacgc tggagtttga ctactggggt camaaccc tggtcaccgt ctcgagc 357 <210〉 694 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 694 gaggtgcagc tgttgsagtc tgggggaggc ttggtacagc ctgggm^c cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gaggae£asa tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attattggtg gtggtcatga gacatactac 180 scagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300 gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 695 <21i> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920·序列表.doc •360· 201245225 <400> 695 gaggtgcagc tgttggagtc tgggggaggc ttj>£tac&gc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat gauacggaga tgacgtgggt ccgccaegct 120 ccagggaagg gtctagagtg ggtctcagct at :aatcggc tgggtcagga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtagg 300 attcctgggc tggtttttga ctactggggt cajiggaaccc tggtcaccgt ctcgagc 357 <210> 696 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醗 <4〇〇> 696
gagglgcagc tgttggagtc tgggggaggc ttsgtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gatgattcga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt. attaatgatg ctggtagttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgc£gtat attactgtgc gaaaggtact 300 gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 697 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 697 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttcgat aatgagaata tgacttgggt ccgccaggct 120 ccagggaagg atctagagtg ggtctcacgg attactgaga ggggtgatgt. gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcgg 300 attcctacgt tggtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 698 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 698 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gatgattcga tfiagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attaatgatg ctggtagttc tacatactac 180 •361 - 163920-序列表.doc 201245225 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcs tgccgaggac accgcggtat attactgtgc gaaagggatt 300 actcctaatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 699 <211> 357 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 699 gaggtgcagc tgttggagtc tgggggaggc 〖tggtacagc ctsgggggtc ccigcgtctc 60 tcctgtgcag cctccggatt cacctttgct gatgagccga tgacttgggt ccgccageci 120 ccagggaag£ gtctagagtg ggtctcacgt attcclcctg agggtgctcc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 clgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggctt 300 attcctgatc tlcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 700 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 700 gaggt^cagc tgttggagtc tgggg£aggc ttg£tacagc ctgggg^S^c cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag gatagtgata tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attgctgcgc ctggtggtag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcgt 300 attcctaatc ttaggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 701 <211> 357 <212> <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 701 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgtt tcggatacta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgatggga ctggtggtga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcag 300 gttcctgagc tgctgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 163920-序列表.doc •362- 201245225 <210> 702 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 702 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga attcctaatc tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg ttgtgtttga tgggggaggc cacctttcag ggtctcagct gttcaccatc tgccgaggat ctactggggt tt^gtacagc gacagtgata atigctgcgc tcccgcgaca accgcggtat caitggaaccc ctggggggtc tgacgtgggt ctggtggtag attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaagatcgt ctcgagc 60 120 180 240 300 357
<210> 703 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 703 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga attccgtctc tgttggagtc ccgccggatt gtctagagtg tgaagggccg acagcctgcg tgacttttga tgggggaggc cacctttgat ggtctcacgt gttcaccatc tgccgaggac ctactggggt m：gtacagc ct£：gcggaga at fgatgagg tcccgcgaca eccgcggtat cagggaaccc ctggggggtc tgacttgggt atggtgcttc attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct tacatactac cacgctgtat ggaaggtgtt ctcgagc 60 120 180 240 300 357 <210> 704 <211> 357 <212> DNA <213>人工序列 <220>
<223>人工序列之描述：合成聚核苷酸， <400> 704 60 120 180 240 300 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt caccttlacl gataagcata tgagttgggt ccgccaggct ccagggaagg gtctagagtg ggcctcacgg atttcgcctg atggcacgta tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca actccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc ggaaggtgti attccgtctc tgactttlga ctactggggt cagggaaccc tggtcaccgt ctcgagc <210> 705 <211> 357 <212> DNA <213>人工序列 363 · 163920-序列表.doc 357 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 705 gaggtgcagc tgUggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gaggatgata tgacttgggt .ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgcggttg atggtgatcg gacatactac 180 gcagactccg tgaagggccg gttcaccaic tcccgcgaca attccaagaa cacgctgtac 240 ctgcaaatga acagcctgcg taccgaggac accgcggtat attactgtgc gaaagggaag 300 acgccgcatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 706 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 706 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag ccgccggatt cacctttgat ctggcggaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgalgagg atggtgcttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcag 300 gttcctectt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 707 <211> 357 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 707 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gattcgatga tgtcgtgggt ccgccaggcg 120 ccagggaagg gtctagagtg ggtctcacgg attgatcctg ggggtgctca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg 300 actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 708 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <40Q> 708 163920-序列表.d〇c 364- 201245225 gaggtgcagc tgttggagtc tgggggaggc ttgi：tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag catiicggata tgagttgggt ccgccaggct 120 tcagggaagg gtctagagtg ggtctcacgt attitaUata gtggtcagtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accucggtat attactgtgc gaaaggggtg 300 actccggatt tgacgtttga ctactggggt cagngaaccc tggtcaccgt ctcgagc 357 <210> 709 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 709
gaggtgcagc tgttggagtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gagucggaga tgaattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attacgacgg atggtgattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcct^gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accucggtat attactgtgc gaaagggcgt 300 attcctactc ttcattttga ctactggggt cag丨igaaccc tggtcaccgt ctcgagc 357 <210> 710 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 710
gaggtgcagc tgttggagtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctcaggatt cacctttgat gatiigtgata tgacttgggt ccgccaggct 120 ccagggaaga gtctagagtg ggtctcatat attoggggtg atgatgatga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tccogcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acc；{cggtat attactgtgc gaaaaatcgg 300 attcctgatc ttgtgtttga ctactggggt cagngaaccc tggtcaccgt ctcgagc 357 <210> 711 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 711 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat gtggcggata tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attagtccga atggttggga tacatactac 180 163920·序列表.d〇c -365· 201245225 gcagactccg tgaagggccg gticaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg teccgaggac accgcggtat attactgtgc gaaacatgct 300 tctacggagg ggccgactgc ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 age 363 <210> 712 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 712 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 ccctgigcag cctccggatt cacctttggg ccgtatgaca tggggtgggt ccgccaggct 120 ccagggaagg £tctggagtg ggtctcatgg atttctgctc atggticgtt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggat accgcggtat attactgtgc gaaatggcct 300 tataagtttg actactgggg tcagggaacc ctggtcaccg tetegage 348
<210> 713 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 713 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctmsgstc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg agtgggtcta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg attggtagta atggtgcgga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggae accgcggtat attactgtgc gaaagggatg 300 gttcctaatt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 714 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 714 gaggtgcagc tgttggastc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat cgttttgata tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcL attagtggta gtggtggtag cacatactac 380 gcagactccg tgaagggccs gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggae accgcggtat attactgtgc gaaagatcgt 300 163920·序列表.doc -366- 201245225 attcclaatc ttglgtttga ctactggggt cags;gaaccc tggtcaccgt ctcgagc 357 <210> 715 <211> 357 <212> mh <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 715 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tcttctcgtc tfittggagtc tgggggaggc ttgiitacagc ctggggggtc cctgcgtctc cctccggatt cacctttggg gagagtgata tgaagtgggt ccgccaggct gtctagagtg ggtctcaagt attagtccga aiggttggga tacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac acq;cggtat attactgtgc gaaatctcct ttaagtttga ctactggggt cag^gaaccc tggtcaccgt ctcgagc 60 120 180 240 300 357
<210> 716 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 716 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga attcctaatc tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg ttgtgtttga tgggggaggc cacctttgat ggtctcaicg gttcaccatc cgccgaggat ctactggggt ttg^tacagc agtagtgaga att：^agaatc tcc>:gcgaca accicggtat cag：igaaccc
Ctggggggtc teagttgggt agggtggtgc attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct gacatactac cacgctgtat gaaagatcgt ctcgagc 60 120 180 240 300 357
<210> 717 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 717 gaggtgcagc tgttggagtc tgggggagec ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacccttgat gcgtatccta tgtattgggt ccgccaggct ccagggaagg gtctagagtg ggtctcatgg attgcttcgg gtggtggtgc gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtacg aagaattttg actactgggg tcagggaacc ctggtcaccg tctcgagc
<210> 718 <211> 360 <212> DNA 163920-序列表.doc 60 120 180 240 300 348 -367- 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 718 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatg agttattcta tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attacttcta atggtaatcg gacatactac 180 gcagactccg tgaaggsccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat aitactgtgc gaaatcgact 300 ggggctaata gtaggaattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 719 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 719 gaggtgcagc tgttggagtc tggmassc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gggtatctga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgcggcta atggtatgca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaagccg 300 aggggtattt gggatgggga tlttgactac tggggtcagg gaaccctggt caccgtctcg 360 age 363 <210> 720 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 720 gaggtgcagc tgttggagtc tgggggaggc ttggtaca£c ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat gagtetaega tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atteggeate cgggtgagtt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccggggac accgcggtat attactgtgc gaaagggctt 300 attcctgatc ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 721 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc -368- 201245225 <400> 721 gaggtgcagc tgttggagtc tgsssgaggc ttj^gtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg atj：tatagta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg af.gcgccgc cgggtggtag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacagtcg 300 ctgacggggt atagtaggtc ttttgaccac tgj;ggtcagg gaaccctggt caccgtctcg 360 age 363 <210> 722 <2U> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醗 <400> 722
gaggtgcagc tgttggagtc tgggggaggc tt^igtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg cai；aatccga tgtcgtgggt ccgccacgct 120 ccagggaagg gtctagagtg ggtctcaacg aticctgcga atggtcgtcc tacatcctac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatagt 300 cagcagccgg gtcgtcggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 723 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 723 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct aattatcata tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attcctgata gtggtaagca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctacaaatga acagcctgcg tgeegaggae accgcggtat attactgtgc gaaaggtagg 300 attccgtctc ttctttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 724 <2ll> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <40Q> 724 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 .369· 163920-序列表.doc 201245225 tcctglgcag cctccggatt cacctttgcg cagtatcata tgcgttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcaacg attaatgata ttggtagtaa tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg gggcggggga gtttttcttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc <210> 725 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 120 180 240 300 360 <400> 725 gagstgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt caccttttct ccagggaagg gtctagagtg ggtctcaacg gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac catgcgggtc agccgccttt tgaclactgg <210> 726 <211> 360 <212> DNA <213>人工序列 <220> ttggtacagc ctggggggtc cctgcgtctc tcgtatgata tgaagtgggt ccgccaggct attagtgcgt ctggtgtgtt tacatactac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gaaacgggag ggtcagggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360
<223>人工序列之描述：合成聚核苷酸 <400> 726 gaggtgcagc tgttggagtc tggggeaggc tcctgtgcag cctccggatt cacctttaat ccagggaagg gtctagagtg ggtctcaact gcagactccg tgaaggsccs gttcaccatc ctgcaaatga acagcctgcg tgccgaggac actcttgctt ctaattattt tgactactgg ttggtacagc ctggggggtc cctgcgtctc ggttatgcta tgagttgggt ccgccaggct aitaatgcta atggiaagla tacatactac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gaaaaagttg ggtcagggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360
<210> 727 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 727 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt cacctttate ccagggaagg gtctagagtg ggtctcaagt gcagactccg tgaagggccg gttcaccatc ttggtacagc ctggggggtc cctgcgtctc gattatgata tgaagtgggt ccgccaggct attactgcgc ttggtaagaa gacatactac tcccgcgaca attccaagaa cacgctgtat 60 120 ISO 240 163920·序列表.doc -370- 201245225 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatagt gttaagtatc ctcttaatct ttttgactac tggggtcagg gaaccctggt caccgtctcg age 300 360 363 <210> 728 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 728 gaggtgcagc tgttggagtc tgggggaggc tt：;gtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttccg ca:tatacga tggcgtgggt ccgccaggct ccagggaagg gtctggagtg ggtctcatct at ;cagtcgc ctggttggcg gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgeegaggat accgcggtat attactgtgc gaaatatggg gatggtcttc ctttgacttt tgactactgg £gi:cagggaa ccctggtcac cgtctcgagc <210> 729 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 360 <400> 729 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttagt £gtacgccga tgtcttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcacgt attggggatg agg£tcagga gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg actccggatt igacttttga ctaciggggt cagggaaccc tggtcaccgt ctcgagc 60 120 180 240 300 357
<210> 730 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 730 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga attcctactc tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg ttcattttga tgggggaggc caccltta£t ggtctcagcg gttcaccatc tgccgaggac ctactggggt ttggtacagc agtagttcga attiggtctg tcc:gcgaca accgcggtat cagggaaccc
Ctggggggtc tgtcttgggt atggtccgag attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaagggcgt ctcgagc 60 120 180 240 300 357 -371- 163920-序列表.doc 201245225 <210> 731 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成琴核苷酸 <400> 731 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccsgatt cacccttaat cctggtgaga tgacgtgggt ccgccaggcc 120 ccagggaagg gtctagagts ggtctcaagt attgatgggt ctggttcttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaLgac accgcggtat attactgtgc gaaagggcgt 300 attcctactc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 732 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 732 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct gagtctatga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgggtatc ctggtgctac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacectgtat 240. ctgcaaatga acascctgcg tgccgaggat accgcggtat attactgtgc gaaaggtggt 300 agtcgggatg ataattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 733 <211> 372 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 733 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtecag cctccggatt cacctttggi cagcatagta tgcattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attagtgttc cgggtccgaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ga^aagtctt 300 agggatttgc gtccgggtga tagiaasagt tttsactact ggggiqggg aaccctggtc 360 accgtctcga gc 372 <210> 734 <211> 348 163920·序列表.doc -372- 201245225 <2\2> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 734 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga SStcgttttg tgttggagtc tgggggaggc ttcgtacagc ctggsgggtc cctgcgtcic cctccggatt cacctttggt tcigctgcta tggattgggt ccgccaggct £tctagagtg ggtctcatct atlaatgata tgggttctaa tacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgcat acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagggt actactgggg tcagggaacc ctigtcaccg tctcgagc 60 120 180 240 300 348 <210> 735 <211> 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 735 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga agggttcctg tgttggagto tgggggaggc ttggtacagc ctggggggtc cotgcgtctc cctccggatt cacctttggt tatgatagga tggcttgggt ccgccaggct gtctagagtg ggtctcatcg attgatggtc ctggtggggc tacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggagg attttgacta ctggggtcag ggaaccctgg tcaccgtctc gage 60 120 180 240 300 354 <210> 736 <211> 357 <212> im <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 736 gagglgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gttcctgatt tgttggagto cctccggatt gtctagagtg tgaagggccg acagcctgcfi tgaattttga tgggggaggc cacctttggt ggtctcaagg gttcaccatc tgccgaggac ctactggggt ttggtacagc gagtatgaga attgatccgt tcccgcgaca accgcggtat cagggaaccc ctggggggtc tgacttgggt ttggttctga attccaagaa attactgtgc tggtcaccgt ccigcgtctc ccgccaggct gacatactac cacgctgtat egaaggtgtg ctcgagc 60 120 180 240 300 357 酸 核 聚 成 合 M: 描 之 列列 序序 70 A工 工 7336跑人 人 0717赛办3> 11 1 1 11 2 -373- 163920-序列表.doc 201245225 <400> 737 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt cacctttgat ccagggaagg gtctagagtg ggtctcaact gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac actcttagtg cgactaagtt tgactactgg ttggtacagc ctggggggtc cctgcgtctc aagtatgtta tggggtgggt ccgccaggct attggtagtt atgglggggc tacatactac tcccgcgaca attccaagaa cacgctgtat accgcgstat attactgtgc gaaaaggctt ggtcagggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360 <210> 738 <2U> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400〉 738 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgag gattatgtga tgggttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcaact aitgcgcatc ggggtgatat tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtagg cgtcttagtg attatcggu tgactactgg g£tca£ggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360
<210> 739 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 739 gaggtgcagc tgttggagtc Xgggzgzggc ttggiacagc ctggggggic cctgcgtctc tccigtgcag cctcc^att cacctttggg cagtugata tgtattgggt ccgccaggct ccagggaagg gtctagagtg ggtctcagcg attagtccgg ctggtactgg tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg gatcggtcta gtctttttga ctacaggggt cagggaaccc tggtcaccgt ctcgagc <210> 740 <211> 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 740 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttaag £ata〇S££ta tgacgtgggt ccgccaggct 60 120 180 240 300 357
60 163920.序列表.d〇c •374· 120 201245225 ccagggaagg gtctagagtg ggtctcaagt atttctagtt atggtcgtga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaattgaat 300 gcggcgctgg gttttgacu ctggggtcag ggaaccctgg tcaccgtctc gage 354 <210> 741 <211> 354 <212> 眺 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 741
gaggtgcagc tgttggagtc tgggggaggc tlggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt ccgtatccga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attaatgege cgggtacgag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acc.scggtat attactgtgc gcaacagatg 300 tctagtgggg tttttgacta ctggggtcag gga.accctgg tcaccgtctc gage 354 <210> 742 <21卜 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 742
gaggtgcagc tgttggagtc tgggggaggc ttg；jtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg aatcaggata tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt att；iatagtt ctggtcagct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcc<:gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acc；icggiat attactgtgc gaaagttaag 300 tctcttgcgc ggtttgacca ctggggtcag ggaacccigg tcaccgtctc gage 354 <210> 743 <211> 351 <212> WA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 743 gaggtgcagc tgttggagtc tgggggaggc ttgijtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttcct gagectgata tgaagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attiigtccga atggttggga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg igccgaggat accacggtat atractgtgc gaaaccggct 300 163920·序列表.doc -375- 201245225 caggttctgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 744 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 744 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggsgtc cclgcgtctc 60 tcctgtgcag cctccggatt cacctttgag cagtatgtga tgggttgg£t ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attggtacgt cgggtaagia tacalactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacd attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaacgtagg 300 tctctgactc gggttcattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 745 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 745 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gtggagcata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg attacgggtg atggtgatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacggtt 300 tcgtggaatg gtcgttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 746 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400〉 746
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg tggtataata tgggttgggt ccgccaggct 120 ccamaagg gtctggagtg ggtctcaagg attgctccgt ctggtattai tacatactac 180 gcagactccg tgaagggccs gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat auactglgc gaaagggttg 300 cgtggtaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 747 <211> 348 <212> DNA 163920-序列表.doc -376- 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 747 gaggtgcagc tgttggagtc tggggsaggc ttj;gtacagc ctggggggtc cctgcgtctc tcciglgcag cclccggatt cacctlttcg aavtatgaga tgaggtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcatct atucttcgg ctggtactga tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagtcg cttaattttg actactgggg icagggaacc ct^.gtcaccg tctcgagc 60 120 180 240 300 348
<210> 748 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 748 gaggtgcagc tcctgtgtag ccagggaagg gcagactccg ctgcaaatga agtatgtttg tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg actactgggg tgggggaggc cacctttgat ggtctcaatt gttcaccatc tgccgaggac tcagggaacc ttggtacagc gaggagccga attgatccgg tcccgcgaca accgcggtat ctggtcaccg ctggggggtc tgacttgggt gtggtggggc attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct gacatactac cacgctgtat gaaatctaat 60 120 180 240 300 348 <210> 749 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
60 120 180 240 300 360 363 <400> 749 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt caccttttcc gcgtatccta tgcattgggt ccgccaggct ccagggaagg gtctagastg ggcctcatct attgcttctt cgggtattac gacatactac gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accicggtat attactgtgc gaaatttact cggctgcatt ttcctgcgca gtttgactac tggigtcagg gaaccctggt caccgtctcg age <210> 750 <211> 357 <212> DNA <213>人工序列. <220> <223>人工序列之描述：合成聚核苷酸 377· 163920-序列表.doc 201245225 <400> 750 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gattatgega tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg atttctcctg agggttctag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaaiga acagcctgcs tgeegaggae accgcggtat attactgtgc gaaattgcgg 300 ccgtatgcgt cgaagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 酸 苷 核 聚 成 合 述 描 之 歹 歹 序 序 18Α工 工 7534DN人 人 0>]>2>3>0>3> 1111 22 2222 22 V vv< V < <400> 751 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga catcattttg tgttggagtc tggggsaggc ttggtacagc ctggggggtc cctgcgtctc 60 cctccggatt cacctttasg ccstatgata tgggttgggt ccgccaggct 120 gtctagagtg ggtctcaacg atttctcatc agggtaatcg gacatactac 180 tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 acaicctgcg tgccgaggac accgcggtat attactgtgc gaaagtstct 300 actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 752 <211> 354 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 752 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga catcggggga tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 cctccggatt cacctrttct gcgtataata tgtggtgggc ccgccaggct 120 gtttagagtg ggtctcatgg attaattcga ctggttctcg tacatactac 180 tgaagggccg gltcaccatc tcccgcgaca attccaagaa cacgctgtat 240 acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaattgg 300 ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gage 354 <210> 7S3 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 753 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctecgtctc 60 tcctgtgcag cctccggatt cacctttgat aggtatcgga tggggtgggt ccgccaggct 120 163920-序列表.doc •378· 201245225 ccagggaagg gtctagagtg ggtctcaacg aitsatcggc tgggtcagag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accg；cggtat attactgtgc gaaagtgaag 300 aagcataagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 754 <211> 351 <212> DNA <213>人工序列 <220〉 <223>人工序列之描述：合成聚核苷酸 <400> 754
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg cattataata tgcggtgggt ccgccaggct 120 ccagggaagg glctagagtg ggtctcaacg attacgaaga ctggttttcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300 cagtttgatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 755 <211> 354 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 755
saggtgcagc tgttggagtc tgggggaggc ttastacagc ctgssgggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttat ccttalagta tgcattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaact attgatggta gtggtatgtt tacatactac ISO gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accg.cggtat attactgtgc ggaagattct 300 ctgaaggctt cttttgacta ctggggtcag ggasccctgg tcaccgtctc gage 354 <210> 756 <211> 351 <212> DNA <2J3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 756 gaggigeage tgttggagtc tgggggaggc ttgi；tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg cttlatggga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatat attiiggeett atggtcatac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggat acciicggtat attactgtgc gaaaaagcgg 300 163920·序列表.doc 379· 201245225 aagaagaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 757 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 757 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct aggtatcgga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attactccgt atggtgctca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatggt 300 aagtggtatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <2I0> 758 <211> 351 <212> IM <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<4〇〇> 758 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat gagtatgcga tgaggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgatcgtc tgggtcttca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgcigtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtggs 300 ccttttacgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 759 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 759 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc . 60 tcctgtgcag cctccggatt cacctttgag cggtacaata tgcettgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgatcggc tgggtcttgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgasgac accgcggtat attactgtgc gaaagcgggt 300 tcgtggtctt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 760 <211> 354 163920·序列表.doc 380- 201245225 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 760 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga cagccttatc tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg cttttgacta tgggggaggc cacctttggt ggtctcaacg gttcaccatc tgccgaggac ctggggtcag ttg；>tacagc atltatgata atttcgtcgt tccogcgaca accjscggtat ggaaccctgg ctggggggtc tgaagtgggt cgggtactca attccaagaa attactgtgc tcaccgtctc cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaatatcct gage 60 120 180 240 300 354 <210> 761 <211> 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 761 gaggtgcagc tattggagtc tgggggaggc ttgj：tacagc dggggggtc cctgcgtctc tcctgtgcag cctccggatt caccttttgg gtgi:atgata tgcgttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcaacg atti:ctgcga ctggtgtgca tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgeegaggae acciicgstat attactgtgc gaaatatccg cctgctggtc ggtttgacca ctggggtcag ggaaccctgg tcaccgtctc gage <210〉 762 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 762 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga caggtgaata tfittggagtc tgggggaggc ttg{：tacagc ctggggggtc cctgcgtctc cctccggatt caccttttcg actlatgata tgatttgggt ccgccaggct gtctagagtg ggtctcagct attlctccta atggtactgg tacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgc〇£aggac accs;cggtat attactgtgc gaaacctccg ctgagtttga ctaccggggt cagi；gaaccc tggtcaccgt ctcgagc <210> 763 <211> 348 <212> DNA 人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc -381· 60 120 180 240 300 354 60 120 180 240 300 357 201245225 <400> 763 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag aaggaggata tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacat atttcgccga atggttatgc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagttgg 300 tctagttttg actactgggg tcagggaacc cig^icaccg tcicgagc 348 <210> 764 <211> 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 764 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gctactccga tggagtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctgaga gtggttatag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggaat 300 tcgactactg gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gage 354
<210> 765 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 765 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat acggtggata tggagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagi attagteega atggttg£ga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggae accgcggtat attactgtgc ggaagctccg 300 catcgggcgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 766 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 766 gaggtgcagc tgttggagtc tggggggggc ttggtacagc ctggggggtc cctgc£tctc 60 tcctgtgcag cctccggatt cacctttgag gataaggaga tgagttgggt ccgccaggct 120 163920·序列表.doe •382- 201245225 ccagggaagg gtctagagtg ggtctcacgg attgatgctt tgggtgattc lacataciac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggatg 300 gitcctcgtc tgaagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <21.0> 767 <211> 342 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 767
ga££tgcagc tgttggagtc tgggggaegc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gatcattcga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagat attgagccgc atggtgttca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaatcctact 300 tttgactact ggggtcaggg aaccctggtc accgtctcga gc 342 <210> 768 <211> 366 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 768
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg ccgcatacta tgcattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attggtccgg atggtactac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtteg 300 tatagttggg alcgtgggtg gacgttlgac tactggggte agggaaccct ggtcaccgtc 360 tegage 366 <210> 769 <211> 357 <212> IM <213>人工序列 <220> <223>人工序列之描述·合成聚核苷酸 <400> 769 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttat getteggata tgaagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attagteega atggttgsga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920-序列表.doc •383 - 201245225 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctgat 300 tatacltatc attcttttga ctactggggt caggggaccc tggtcaccgt ctcgagc 357 <210> 770 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 770 gaggtgcagc tgttggagtc tggmaggc ttggtaca^c ctgggggstc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg cattataata tgcgglgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attacgaasa ctggttttcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300 cagtttgatt ttgactactg ggstcaggga accctggtca ccgtctcgag c 351 <210> 771 <211> 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述··合成聚核苷酸 <400> 771
gagstgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgictc 60 tcctgtgcag cctccggatt caccttttcg cattatcata tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagtt attgggccga ggggtatttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtal 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcgcct 300 tcgcgtcata ggtttgacta ctggg£tcag ggaaccctgg tcaccgtctc gage 354 <210> 772 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 772
gaggtgcagc tgttggagic tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcas cctccgsatt cacctttaat gagtatgega tgaggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgategte tgggtcttca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtggg 300 ccttttacgt ttgactactg gggtca^gga accctggtca ccgtctcgag c 351 <210> 773 163920·序列表.doc -384· 201245225 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 773 gaggtgcagc tgttggagtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttggt aati:atagta tgaagtgggc ccgccaggct ccagggaagg gtctagagtg ggtctcaact attactcctg atggttggta tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca actccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accjtcggtat attactgtgc gaaagtgggg gatgctgttt gggggtggat tggtgggttt gaci;actggg gtcagggaac cctggtcacc gtctcgagc 60 120 180 240 300 360 369
<210> 774 <211> 348 <212> 腕 人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 774 gaggtgcagc tgttggagtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttggg gatr.atggta tgaagtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcagct attacgtcta atggtgat.tt tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaafiaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accjjcggtat attactgtgc gaaatctttg tataagtttg actactgggg tcagggaacc ctgi;tcaccg tctcgagc 60 120 180 240 300 348
<210> 775 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 775 gaggtgcagc tgttggagtc tgggggaggc ttgj：tacagc ctggggggtc cctgcgtctc tcctgtgcag gctccggatt cacctttcct acttataaga tggggtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcattt attj»attatt ggggttggcg gacatactac gcagactccg tgaagggccg gttcaccatc tcc<:gcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac acc：^cggtat attactgtgc gaaaagtccg tattcttgga ctcatgatag tcctcatttt gactactggg gtcagggaac cctggtcacc gtctcgagc 60 120 180 240 300 360 369
<210> 776 <211> 348 <212> DNA 163920·序列表.doc 385- 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 776 gaggtgcagc tgttggagtc tgggggflggc uggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcas cctccggatt cacctttagg ccttatacga tgtgttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgt attagteatg ctssttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgiat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtar attactgrgc gaaaaggatg 300 tcttcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 777 <211> 366 <212> UNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 777
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag ccxcczg2.it cacctttcag aattatcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attagtgg^a ctggtaagaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 cigcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaactcct 300 cagaattatt ttagtgtgcg tcggtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 778 <211> 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 778
laggtgcagc tgttggagtc tggggfaggc Uggtacagc ctsggggg丨c cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gcgtatacta tggggtgggt ccgccaggct 120 ccamaagg gtctagagtg ggtctcaaag atttcgacgt ctggtgggca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctttg 300 aattggtggg cgtttgacta ctggggtcag ggaaccctgg tcaccgtctc g^gc 354 <210> 779 <211> 351 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc • 386- 201245225 <400> 779 gaggtgcagc tgttggagtc tgggggaggc ttg；>tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat gcgtatccta tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg atlisatggtt atggtcggca tacaiactac 180 gcagactccg t£aagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acciscggtat attactgtgc gaaagggatt 300 attcctaatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 780 <211〉 357 <212> DMA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <4〇〇> 780
gaggtgcagc tgttggagtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gcguttgata tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg att cgccta gtggttctgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tccogcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accjicggtat attactgtgc gaaagggcgt 300 Stgccggatc itggttttga ctactggggt cagitgaaccc tggtcaccgt ctcgagc 357 <210> 781 <211> 351 <212> DiNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 781
gaggtgcagc tgttggagtc tgggggaggc ttgctacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aguatgcga tggggtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attKgggcta agggtttgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accj：cggtat attactgtgc gaaagcggct 300 aggggtaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 782 <2U> 348 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 782 gaggtgcagc tgttggagtc tBgeggaggc ttgjitacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact cggiatcaga tgggttgggt ccgccaggct 120 163920-序列表.doc •387· 201245225 ccagggaagg gtctagagtg ggtctcagtt attaatgttt gggsttcgag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatea acagcctgcg (gccgaggac accgcggtat attactgtgc gaaaatgtct 300 gg£aaetttg cctactgggg tcagggaacc ctggtcacce tctcgagc 348 <21Q> 783 <2U> 351 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 783 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctt 60 icctgtgcag cctccggatt cacctttggg aattatagta tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attattcctg ctggtacgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgcigtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgtcg 300 attaggttgt ttgactaclg gggtcaggga accctggtca ccgtctcgag c 351
<210> 784 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 784 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gcgtatgata tggggtgggt ccgccaggct 120 ccaggeaagg gtctagagtg ggtctcatgg atltctccga acggttacga tacatactac ISO gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggggt 300 etgaagtUg actacigggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 785 <21i> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 785 gaggtgoigc tgttggagtc igggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctllgtt tggtatgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attcaggctg atggtgagca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagcttcg 300 163920·序列表.doc • 388 · 201245225 tatgctcttg tgtatcctcc tgaggagttt gactactggg gtcagggaac cctggtcacc gtctcgagc 360 369 <210> 786 <211> 366 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷狻
<400> 786 gaggtgcagc tgttggagtc tgggggaggc tlggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttacg as.ttatagga tgtcttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcagct attgatgatc igggtgtgtc gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggagg cttaagaata gtcagccgac ggattttgac tactggggtc agggaaccct ggtcaccgtc tcgagc <210> 787 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 360 366
<400> 787 gaggtgcagc tgttggagtc tgggggaggc ttigtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgat ca；jgctcata tgtggtgggt ccgccaggct ccagggaagg gtctagagtg ggtcicattt atcaatcctt cgggttatta tacatactac gcagactccg tgaagggccg gttcaccatc tcocgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac aci:gcggtat attactgtgc gaaaccttcg cttagtccgt cttcttttga ctactggggt canggaaccc tggtcaccgt clcgagc <210> 788 <211> 354 <212> IM <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 357 <400> 788 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga cagaattatc tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg ggtttgacta tgggggaggc cacctttgag ggtctcaaat gttcaccatc tgccgaggac ctggggtcag ttigtacagc actggtcaga attgatgggt tcccgcgaca accgcggtat ggaaccctgg ctggggggtc tgggttgggc ctggtacgta attccaagaa attactgtgc tcaccgtctc cctgcgtctc ccgccaggct tacatactac cacgctgtat £aaaagtacg gage 60 120 180 240 300 354 -389- 163920-序列表.doc 201245225 <210> 789 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 789 gaggtgcasc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gcttatccga tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attcataagg atg£taggat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgceaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagggt 300 acgccggttg atgggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 790 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 790 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct gatgagggta tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgagactg gtggtacggt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accscggtat attactgtgc gaaaatggat 300 gggtctggta catggcagac gtttgactac tggggtca找 gaaccctggt caccgtctcg 360 age 363 <210> 791 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 791 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat agtctgggta tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaut attcgggctg agggtgctta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccecgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggat accgcggtat attactgtgc gaaatatctt 300 geggattetg actactgggg tcagggaacc ctggtcaccg tetegage 348 <210> 792 <211> 360 163920·序列表.doc 390- 201245225 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷耻 <400> 792 gagstgcagc tgttggaatc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttagt gagtcgtata tggagtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcaggt attgatcata ttggtggtgg gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatgat SEtcgtggtg ggtctatgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360
<210> 793 <2U> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 793 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt caccttttct ccagggaagg gtctagagtg ggtctcaagt gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac ggtaggttag actactgggg tcagggaacc ttggtacagc ctggggggtc cctgcgtctc ggtgggtata tgtggtgggt ccgccaggct attggggcta gtggtgcgta tacatactac tcccgcgaca attccaagaa cacgctgtat accscggtat attactgtgc gaaaacgggg ctgitcaccg tctcgagc 60 120 180 240 300 348 <210> 794 <211> 357 <212> DNA <2】3>人工序列 <220> <223>人工序列之描述：合成聚核苷醆 <400> 794 gaggtgcagc tgttggagtc tcctgtgcag cctccggatt ccagggaagg acctagagtg gcagactccg tgaagggccg ctgcaaatga acagcctgcg tttagtaatg gggggtttga tgggggaggc ttgitacagc cacctttgat gagiggcata ggtctcatat att.iggaglc gttcaccatc tcc:gcgaca tgccgaggac accgcggtat ctactggggt cag^gaaccc ciggggggtc cctgcgtctc tggggtgggt ccgccaggct tgggtttgca tacatactac attccaagaa cacgctgtat attactgtgc gaaacgggag tggtcaccgt ctcgagc 60 120 180 240 300 357 <210> 795 <211> 363 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920·序列表.doc -391-
C 201245225 <400> 795 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttiaag actagtccta 〖gtattgggt ccgccaggct 120 ccagggaagg gtctaga&ts ggtctcatcs attgatcgga ctggtgggca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacaggct 300 ctgcttactg atgcgaagcg ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 age 363 <210> 796 <211> 360 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 796 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat ggtcgggata tggtttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagteega gtggtctgga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaacgtcct 300 cagatgctgg ttactaattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 797 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 797 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt aatgatccga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attggtcggg agggtgattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagattct 300 atgeggeate agccgtttga ctactggegt cagggaaccc tggtcaccgt ctcgagc 357 <210> 798 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 798 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 163920·序列表.doc -392- 201245225 tcclgtgcag cctccggatt cacctttgat gagacttata tgaagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg attggggcgt cgggtgctga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattiacg 300 catctgaatg gtcggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 799 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 799
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gggtggccta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attsatattg atggtgctcc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accicggtat attactgtgc gaaaga^gag 300 gcgggttctt ggtcttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 800 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醆 <400> 800
gaggtgcagc tgttggagtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gatcaggcga tgtggtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctoaut attcagggtg atggtggttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acc^cggtat attactgtgc gaaacctagt 300 aagccgtttg actactgggg tcagggaacc ctgj'tcaccg tctcgagc 348 <210> 801 <211> 354 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 801 gaggtgcagc tgttggagtc tgggggaggc ttgatacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag actjjgtcaga tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaat att^atgggt ctggtacgta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920-序列表.doc •393· 300201245225 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcggtg cggaattttg cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gage 354 <210> 802 <211> 372 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 802 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt cacctttagt ccagggaagg gtctagagtg ggtctcagct gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac aggggttgga ttggtcatga tacgcagcct accgtctcga gc <210> 803 <211> 357 <212> DNA <213>人工序列 <220> ttggtacagc ctggggggtc cctgcgtctc gggeatgata tgtcttgggt ccgccaggct attagtcctc atggtacgca tacatactac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gaaagggatt tttgactact ggggtcaggg aaccctggtc 60 120 180 240 300 360
<223>人工序列之描述：合成聚核苷酸 <400> 803 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggeggtc cctgcgtclc tcctgtgcag cctccggatt cacctttgag agtaaggata tgctttfiggt ccgccaggct ccagggaagg gtctagagtg ggtctcatct atttegtegg atggtactca tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaeeac accgcggtat attactgtgc gcaagagctg ggtgggLctt ggcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc <210> 804 <211> 366 <212> DNA <213>人工序列 <220> <223;>人工序列之描述：合成聚核苷酸 <400〉 804 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgcg gategtgata tggtttgsgC ccgccaggct ccagg£aagg gtctagagtg sstctcaggt attggsgcgt cgggtacgtc tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga aca£cctgcg tgeegass^c geegesgtat attactgtgc gaaaggtggg acgggtccta ctgatttgtg ggattttgac tactggggtc agggaaccct ggtcaccgtc 60 120 180 240 300 357 60 120 180 240 300 360
163920-序列表.doc •394· 366 201245225 tcgagc <210> 805 <211> 357 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 805 saggtscagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gcgggttctt tgttgfiagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg ggtcttttga tgggggaggc cacctttgat ggtctcaagt gltcaccatc tgccgaggac ctactggggt ttgg；tacagc gat^agaaga att2.gtgtga tcccgcgaca accicggtat cag|；gaaccc ctggggggtc tgctttgggt gtggtctgca attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaagaggag ctcgagc 60 120 180 240 300 357
<210> 806 <211> 357 <212> ]m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 806 gaggtgcagc tcctgtgcag cctgggaagg £cagactccg ctgcaaatga gcgggttctt tgttggagtc cctccggatt gtctagagtg tgaagggccg acagcctgcg ggtcttttga cgggggaggc cacctttggg ggtctcagat gttcaccatc tgccgaggac ctactggggt ttgi：tacagc cag^agagga atticggctt tcccgcgaca accucggtat cagj：gaaccc
Ctggggggtc tgatttgggt cgggtgggac attccaagaa attactgtgc tggtcaccgt cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaagaggag ctcgagc 60 120 180 240 300 357 <210> 807 <211> 348 <212> m
<213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 807 60 120 180 240 300 348 gaggtgcagc tgttggagtc tgggggaggc ttgjitacagc ctggggggtc tctgcgtctc tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac gcagactccs tgaaaggccg gttcaccatc tcccgcgaca attccatgaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac acc；>cggtat attactgtgc gaaagagctt gggtattttg actacagggg tcggggaacc ctg；5tcaccg tctcgagc <210> 808 <211> 348 <212> mk 395- 163920·序列表.doc 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 808 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacc.tttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaasaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtamtg actactgggg tcggggaacc ctgguaccg tctcgagc 348 <2i0> 809 <211> 348 <212> DNA e13〉人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 809
gaggtgcagc tgttggagtc igggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accecggtat attactgtgc gaaagagctt 300 gggtattttg actaccgggt tcagggaacc ctggtcaccg tctcgagc 348 <210> 810 <21l> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 810 gaggtgcagc tettggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgcaaggct 120 ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 811 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc •396- 201245225 <400> 811 gaggtscagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgca£ cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120 ccaggsaagg gtctagagtg gatctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtattttg actacagggt tcagggaacc ctggtcaccg tctcgagc 348 <210> 812 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 812
gaggtgcagc tgttggagtc tgggggaggc ttgitacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gtctagagtg ggtctcagcg attlctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccgagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtattttg actactgggg tcggggaacc ctg；itcaccg tctcgagc 348 <210> 813 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醆 <400> 813
gaggtgcagc tgttggagac tgggggagsc ttggtacagc ctggggggtc cctgcgtcic 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatgg acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtattttg actactgggg tcggggaacc ctgjjtcaccg tcacgagc 348 <210> 814 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 814 gaggtgcagc tgttggagtc tgggggaggc tlgjjtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 163920·序列表.doc -397- 201245225 gcagactccg igaaaggccg gttcaccatc tcacgcgaca attccaagaa cacsctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcgstat attactgtsc gaaagagcu 300 gggtattttc actactgggg tcggggaacc ctggtcaccg tctcgagc 348 <210> 815 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 815 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgtag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120 ccagggaatg gtctagagtg gatctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtattttg actactgggg icggggaacc ctggicaccg tctcgagc 348
<210> 816 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 816 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctctggatt cacctitgag t£gtatga^a tgcagtgggt ccgccgggct 120 ccagggaagg gtctagagtg ggtctcagcg atatctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgctaatga acagcctgcs tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtatttcg actactgggg tcggggaacc ctcgtcaccg tctcgagc 348 <210> 817 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 817 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgcaaggct 120 ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300 gggtattttg actacagggg tcggggaacc ctgguaccg tctcgagc 348 163920·序列表.doc • 398· <400> 818 gag£tgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gggtattttg 201245225 <210> 818 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醚 tfittggagtc tgggggaggc tti：gtacagc ctggggggtc catgcgtctc cctccggatt cacctttgag tgi：tatgaga tgcagtgggt ccgccgggct gtctaga^tg ggtctcagcg atitctggtg atggttatcg tacatactac tgaaaggccg gttcaccaic tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt actacagggg tcggggaacc ctggtcaccg tctcgagc <210> 819 <211> 348 <212> DNA <213>人工序列 <220> <2之3>人工序列之描述：合成聚核苷酸 60 120 180 240 300 348
<400> 819 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gggtattttg tgttggagtc cctccggatt gattagagtg tgaaaggccg acagcctgcg actactgggg tgggggaggc cacctttgag ggtctcaatg gttcaccatc tgccgaggac tcggggaacc ttggtacagc tggtatgaga atttccgggg tcccgcgaca accgcggtat ctggtcaccg
Ctggggggtc tgcagtgggt atggttatcg attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccgggct tacaiactac cacgctgtat gaaagagctt 60 120 180 240 300 348 <210> 820 <211> 348 <212> DNA c213>人工序列 <220>
<223>人工序列之描述：合成聚核苷醆 <400> 820 60 120 180 240 300 348 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct ccagggaagg gactagagtg ggtctcagcg atttctggtg ac^gttggcg cacatactac gcagactccg tgaaaggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accicggtat attactgtgc gaaagagctt gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc <210> 821 <211> 348 <212> DMA <213>人工序列 399· 163920·序列表,doc 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 821 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggcce sttcaccatc tcccgcgaca attccaagaa cacgct£tat 240 ctgcaaatga acagcctgcg 【gccgaggac accgcggtat attactgtgc gaaagagctg 300 ctctactttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348 <210> 822 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 822 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactagagtg ggtctcagcg atttctggig atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 cigcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctg 300 gggttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 823 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 823
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactaga^tg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 clgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagttg 300 gagtatutg actactgggg tcggggaacc ctggtcaccg tctcgagc 34S
<210> 824 <211> 348 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 824 163920-序列表.d〇c 400· 201245225 gaggtgcagc tgttggagtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttlgag tgg:atgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactagagtg ggtctcagcg att;ctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctficaaatga acagcctgcg tgccgaggat accucggtat attactgtgc gaaagggttg 300 gagtattttg actactgggg tcggggaacc ctgutcaccg tctcgagc 348 <210> 825 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400〉825
gaggtgcagc tgttggagtc tgggggaggc ttgntacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggr.atgaga tgcagtgggt ccgccgggct 120 ccasggaagg gactagagtg ggtctcagcg atti:ctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accj：cggtat attactgtgc gaaagagctg 300 gccttctttg actactgggg tcggggaacc ct£j»tcaccg tctcgagc 348 <210> 826 <211> 348 <212> Wk <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 826 gaggtgcagc tgttggagtc tgggggaggc ttgntacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tgg.atgaga tgcagtgggt ccgccgggct 120 ccagggaags gactagagtg ggtctcagcg att:ctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accucggtat attactgtgc gaaagagctc 300 ttgtactttg actactgggg tcggggaacc ctgj»tcaccg tctcgagc 348 <210> 827 <21i> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 827 gaggtgcagc tgttggagtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tgg:atgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactagagtg ggtctcagcg att-ctggtg atggttatcg tacatactac 180 -401· 163920·序列表.doc 201245225 gcagactccg tgaaa^gccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagttg 300 gagttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348 <210> 828 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 828 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggsggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgsgct 120 ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctg 300 cagttctltg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 829 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 829 gaggtgcagc tgttggagtc tgggggaggc ttsstacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gucaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagctg 300 cicttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348 <210> 830 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 830 gaggtgcagc tgttggagtc tgggesaggc ttggtacggc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120 ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagttg 300 gagttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348 163920·序列表.doc •402· 201245225 <210> 831 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 831. gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga ctcttctttg tgttggagtc cctccggatt gactagagtg tgaaaggccg acagcctgcg actaccgggg tgggggaggc cacctttgag ggtctcagcg gttcaccatc tgccgaggac tcggggaacc ttggtacagc tggtatgaga atttctggtg tcccgcgaca accgcggtat ctggtcaccg ctggggggtc tgcagtgggt atggltatcg attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccgggct tacatactac cacgctgtat gaaagagttg 60 120 180 240 300 348
<210> 832 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 832 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gagtattttg tgttggagtc cctccggatt gactagagtg tgaaaggccg acagcctgcg actactgggg tgggggaggc catctttgag ggtctcagcg gttcaccatc tgccgaggat tcggggaacc ttggtacagc ig)；tatgaga atuctggtg tcccgcgaca accgcggtat cti.gtcaccg ctggggggtc tgcagtgggt atggttatcg attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccgggct tacatactac cacgctgtat gaaaaacttg 60 120 180 240 300 348 <210> 833 <211> 348 <212> DNA <213>人工序列 <220>
<223>人工序列之描述：合成聚核苷酸 <400> 833 60 120 180 240 300 348 gaggtgcggc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagttg cagttclttg actactgggg tcggggaacc ctggtcaccg tctcgagc <210> 834 <211> 348 <212> DNA <213>人工序列 403 - 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 834 gaggtgcagc tgttggggtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaag£gcc£ gttcaccatc tcccgcsaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgc£ tgccgaggat accgcggtat aitactgttc gaaagagccg 300 tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 835 <21I> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 835 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac ISO gcagactccg tgaagggccg gttcaccatc 〖cccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 836 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 836 gaggtgcagc tgttggcgtc tgggggaggc ttggiacasc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg gatctcagct attagtggaa gtggtggtag cacatactac 180 gcagactccg tgaagggccg gtttaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 837 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <4〇ft> 837 gasgtgcasc tgttggaicc tgggggaggc ttggtacagcctggggggtc cctgcgtctc 60 163920·序列表.doc -404- 201245225 tcctgtgcag cctccggatt cacctttggg aangaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct auagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttttg actactgggg tcagggaacc cti：gtcaccg tctcgagc 348 <210> 838 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 838
gaggtgcagc tgttggggtc tgggggaggc tt£：gtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gai;gaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct auagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 839 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 839
gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctgggggctc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgctaatga acagcctgcg tgccgaggat accgcggtat attactgttc gaaagagccg 300 ittcgtttrg actactgggg tcagggagcc ctggtcaccg tctcgagc 348 <210> 840 <211> 348 <212> 腿 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 840 gaggtgcagc tgttggatcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg aaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggictcatct attagtggta gtggtggtag cacatactac 180 gcagactccg ttaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920-序列表.doc •405 - 201245225 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 ttacgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 841 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 841 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctltgag gaggaggaga tgatctgggt ccgccaggct 120 cctgggaagg gtctagagtg gatctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc caccgcgaca attctaagaa cactctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgttc gaaasagccg 300 tttcgmig actacagggg tctgggaacc ttggtcaccg tctcgagc 348 <210> 842 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 842
gaggtgcagc tgttggatcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg aaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attagcggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaseaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 ttacgttttg a.ctactgggg tcaggggacc ctggtcaccg tctcgagc 348 <210> 843 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 843
gaggtgcagc tgttggattc tgggggaggc tttgtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caoctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg gatctcagct attagtggta gtggtggtag cacatsctac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgct£tat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtgt attactgtgc gaaagagccg 300 tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 163920·序列表.doc •406· 201245225 <210> 844 <211> 348 <212> IWA <213>人工序列 <220> <223>人工序列之描述··合成聚核苷酸 <400> 844 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttcgttttg tgttggatcc tgggggaggc ttf：gtacagc ctggggggtc cctgcgtctc cctccggatt cacctttgag ga^gaggaga tgatttgggt ccgccaggct gtctagagtg gatctcagct attagtggta gtggtggtag cacataclac tgaagggccg gttcaccatc tcccgcgaca attccaataa cacgctgtat acagcctgcg tgccgaggat accgcggtat attactgtgg gagagagccg actactgggg tcaggsaacc ctsgtcaccg tctcgagc 60 120 180 240 300 348 <210> 845 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 845 gaggtgcggc tgttggagtc tggggaaggc ttggtacagc ctggggggtc cctgcglctc tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac gcagactccg igaagggccg gttcaccatc tcacgcgaca attccaagaa cacfictgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc <210> 846 <211> 348 <212> DNA <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 348 <400> 846 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttcgttttg agttggagtc tgggggaggc ctggtacagc ctggggggtc cctgcgtctc cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct gtctagagt£ ggtctcagct attEigtggta gtggtggtag cacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggat accgcgstat attactgtgg gaaagagccg actactgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348 <210> 847 <211> 348 <212> DNA <213>人工序列 <220> 163920-序列表.doc 407- 201245225 <223>人工序列之描述：合成聚核苷酸 <400> 847 gaggtgcagc tgttggcgtc tgggggaggc ttg£tacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gasgaggaga tgatttgggt ccgtcaggct 120 ccagggaagg gtctagagtg ggcctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gtccaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg igccgaggat accgcggtat attactgtgg gaaagagccg 300 ttctactacg accactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 848 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 848 gaggtgcagc tgttggcgtc tggsg^aggc ttggtacagc ciggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacclttgag gaggaggaga tgatttgggt ccgtcaggct 120 ccagggaagg gictagastg ggtctcagct attagtggta gtggtggtag cacatactac ISO gcagactccs tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga.acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 ttctacttcg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 849 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 849 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gagaaggaga tgatttgggt ccgtcaegct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 ttcttctacg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 850 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 850 gaegtgcagc tgttggcgtc tsgsegaggc ttggtacagc ctggggggtc cctgcgtctc 60 163920·序列表,doc -408- 201245225 tcctgcgcas cctccggatt cacctttccc cagiaggaga tgatttgggt ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcagct attigtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccrgcgaca attccaagaa cacgctgtat 240 ctgcaaaiga acagcctgcg tgccgaggat acc；»cggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctg：jtcaccg tctcgagc 348 <210> 851 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 851
gaggtgcagc tgttggcgtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttttc gccj>ccgaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accucggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctgutcaccg tctcgagc 348 <210> 852 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 852
gaggtgcagc tgttggcgtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gagnaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtaggc ccggtacgag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accncggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctgi>tcaccg tctcgagc 348 <210> 853 <211> 348 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 853 gaggtgcagc tgttggcgtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt caccttcgag gag^aggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtcgga tgggtttcag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920·序列表.doc •409· 201245225 ctscaaatga acagcctgcs tgccgaggat accgcggtat attactgtgg g&aagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 854 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 854 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccagect 120 ccagggaagg gtctagagtg ggtctcagct at tagteggt ggggtcacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaa^aa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggat accgcggtat attactgtgg gaaagagccg 300 tttcgltatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 855 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 855 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtegee tcggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgeegaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagssaacc ctggtcaccg tctcgagc 348 <210> 856 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 856
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ciggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcagct aitagtcgct ggggtgccag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acascctgcg tgeegaggat accgcggtat attactgtgg gaaagagccg 300 tttcgltatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 857 163920-序列表.doc •410· 201245225 <211> 34E <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 857 gaggtgcagc tgttggcgtc tgggggaggc tlt：gtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gai:gaggaga tgatugggt ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcagct atiagtaggc agggtgggag cacatactac ig〇 gcagactccg tgaagggccg gtlcaccatc tccxgtgaca attccaagaa cacgctgtat 24〇 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atiactgigg gaaagagccg 3〇〇 tttcgttatg actactgggg tcagggaacc ct|；gtcaccg tctcgagc 345 <210> 858 <211> 348 <212> DNA <213>人工序列
<220> <223>人工序列之描述：合成聚核苷酸 <400> 858 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcfitctc ζ〇 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtgtgt ccggttggag cacatactac ig〇 ^cagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 3〇〇 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 345 <210> 859 <211> 348 <212>1M <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 859 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ccggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gagnaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct att;igtcggt ggggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accjscggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctgutcaccg tctcgagc 348
<210> 860 <211> 348 <1\2> DNA 人工序列 <220> <223>人工序列之描述：合成聚核苷酸 -411 - 163920-序列表.doc 201245225 <400> 860 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtcgga acggtctgag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg saaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 861 <211> 348 <212> 腕· <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 861 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctgggggglc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggi ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtgggc tgggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcsgtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 862 <211> 348 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 862 gaggtscagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcetctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtclagagtg ggtctcagct attagtgcgt tgggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgltatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 863 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400〉 863 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 163920·序列表.doc -412- 201245225 ccagggaagg gtctagagig ggtctcagct attagtcgca ggggttacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat acc^cggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctg：gtcaccg tctcgagc 348 <210> 864 <2U> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 864
gaggtgcagc tgttggcgtc tgggggaggc ttgistacagc ctgsggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gagj；aggaga tgatttgggt ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcagct atugtaggc acggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc ccccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accj：cggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcaggga%cc ctgjjtcaccg tctcgagc 348 <210> 865 <211> 348 <212> Wh <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 865
gaggt^cagc tgttggcgtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag £agi；aggaga tgatttgggt ccgccaggct 120 ccagggaagg gtclagagtg ggtctcaagc att^igcagga gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 cigcaaatga acagcctgcg tgccgaggat acciicggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctgjitcaccg tctcgagc 348 <210> 866 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 866 gaggtgcagc tgttggcgtc tgggggaggc ttg|：tacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gag|：aggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtcgga tcggtaacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcs： tgccgaggat acciicggtat attactgtgg gaaagagccg 300 163920-序列表.doc -413- 201245225 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 867 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 867 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cclccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtgggc acggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 868 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 868 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct atttcgaggt ggggtggtag cacatactac 180 gcagactccg tgaagggccg ettcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagaeccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 869 <2il> 348 <212> IXNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 869 gaggtgcagc tgttggcgtc iseesgassc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgget ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgc£gtat attactgtgg gaaagagccg 300 ttcatgtatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 870 <211> 348 163920-序列表.doc 414- 201245225 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 870 gaggtgcagc tcctgcgcag ccagggaagg gcagactccg ctgcaaatga ttcccgtacg tgttggcgtc tgggggaggc cctccggatt cacctttgag glctagagtg ggtctcagct tgaagggccg gttcaccatc acagcctgcg tgccgaggat actactgggg tcagggaacc ttgi；tacagc ctggggggtc cctgcgtctc gag£；aggaga tgatttgggt ccgtcaggct att£.gtggta gtggtggtag cacatactac tcccgcgaca attccaagaa cacgctgtat acc£：cggtat attactgtgg gaaagagccg ctgsitcaccg tctcgagc 60 120 180 240 300 348
<210> 87i <211> 348 <212> DNA <213>人工序列 <220〉 <223>人工序列之描述：合成聚核苷酸 <400> 871 gaggtgcagc tcctgcgcag ccagggaagg gcagaciccg ctgcaaatga tttcgttatg tgttggcgtc cctccggatt gtctagagtg tgaagggccg acagcctgcg actactgggg tgggggaggc cacctttgag 2gtctc&gct gttcaccatc tgccgaggat tcagggaacc ttgi：tgcagc gag{：aggaga atti-.gtggta tcccgcgaca acci:cggtat ctgiitcaccg
Ctggggggtc tgatttgggt fitggtggtgg attccaagaa attactgtgg tctcgagc cctgcgtctc ccgtcaggct cacatactac cacgctgtat gaaagagccg 60 120 180 240 300 348 <210> 872 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 872 60 120 180 240 300 348 gaggtgcagc tgitggcgtc tgggggaggc ttgutacagc ctggggggtc cctgcgtctc tcctgcgcag cctccggatt cacctttgag gaguaggaga tgatttgggt ccgtcaggct ccagggaagg gtctagagtg ggtctcagct attiigtggta gtggtggtag cacatactac gcagactccg tgaagggcce gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accucggtat attactgtgg gaaagagccg ttgtactatg actactgggg tcagggaacc ctgjjtcaccg tctcgagc <210> 873 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 -415- 163920-序列表.doc 201245225 <400> 873 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccg^att caccttlgag gaggaggaga tgatttgggt ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ct£caaatga acagcctgcg tgccgaggat accgcggtat attacigteg gaaagagccc 300 atstactatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 874 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <40Q> 874 gaggtgcagc tgttggcgtc tggggsaggc ttggtacagc ctggggggic cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtagga acggtttcag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgigg tcagggaacc ctggtcaccg tctcgagc 348 <210> 875 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 875 gaggtgcagc tgttggcfitc tgggggaggc itggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtcgca cgggtgggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 876 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 876 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 163920·序列表.doc -416- 201245225 ccagggaagg gtctagagtg ggtctcagct attg.gtcggg agggtgggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accs；cggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctgitcaccg tctcgagc 348 <210> 877 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 877
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccgggtt cccctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtcggc agggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 878 <211> 348 <212> WA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400〉 878
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtcicagct attagtaggg gcggtgggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 879 <231> 348 <212> m <2】3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 879 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggcl 120 ccagggaagg gtctagagtg ggtctcagct attagtcgca cgggttacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 163920·序列表.doc -417- 201245225 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <21Q> 880 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 880 gaggtgcagc tgttggcgtc tgggggaggc tcctgcgcag cctccggatt cacctttgag ccagggaagg gtctagagtg ggtctcasct gcagactccg tgaagggccg gttcaccatc ctgcaaaiga acagcctgcg tgccgaggat tttcgttatg actactgggg tcagggaacc <210> 881 <211> 348 <212> DNA <213>人工序列 <220> ttggtacagc ctggggggtc cctgcgtctc gaggaggaga tgatttgg£t ccgccaggct attagtagga acggtaggag cacatactac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgg gaaagagccg ctggtcaccg tctcgagc 60 120 180 240 300 348
<223>人工序列之描述：合成聚核苷酸 <400> 881 gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgcscas cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac gcagactccg tgaagggccg gticaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg tttcgttatg actactgggg tcassgaacc ctggtcaccg tctcgagc <210> 882 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 882 gagstgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatitgggt ccgccaggct ccagggaagg gtctagagte ggtctcagct attagtagga agggtagcag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg tttcgttaig actactgggg tcagggaacc ctggtcaccg tctcgagc <210> 883 <211> 348 <212> DNA 60 120 180 240 300 348 60 120 180 240 300 348
163920·序列表.doc 418- 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 883 gaggtgcagc tgttggcgtc Cgggggaggc ttg£；taca£c ctggsgggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gags：aggaga t^atttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attzigtcggg gcggttggag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat acc{：cggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctgs：tcaccg tctcgagc 348 <210> 884 <2U> 348 <212> DNA <213>人工序列 <220>
<223>人工序列之描述：合成聚核苷酸 <400〉 884 gaggtgcagc tgttggcgtc tgggggaggc ttg{：tacagc ctgggggglc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gags：aggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct att£.gtcgct cgggttacag cacatactac 180 gcagactccg tgaagggccg ittcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat acciicggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcafiggaacc ctgiitcaccg tctcgagc 348 <210> 885 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 gaggtgcagc tgttggcgtc tgggggaggc ttg^tacagc ctgggggglc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gagi：aggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attugtagga acggtatgag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accncggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctgj【tcaccg tctcgagc 348 <210> 886 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 •419· 163920-序列表.doc 201245225 <400> 886 gaggtgcagc tgttgeagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt caccttl^ag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acaecctgcg tgccgaggat accgcggtai attactgtgs gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> S87 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 887 gaggigcagc tgttggagtc tggggaaggc ttggtacagc ctggggggic cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagcatgaga tgatttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgcigtat 240 ctgcaaatga acagcctgcg tcccgaggac accgcggtat attactgtgc gaaagagccg 300 cttaggtttg actactgggg ccagggaacc ctggtcaccg tctcgagc 348
<210> 888 <211> 348 <2!2> DNA <2i3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 888 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatc cacctttact gagtatgaga tgatttgggt ccgccaggct 120 ccagggaagg gtctggagtg gatctcatct atttcgggta atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat atttctgtgc gaaagagccg 300 cttagstttg actacagggg tcagggaacc ctggtcacce tctcgagc 348
<210> 889 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 889 gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgcaaggct 120 ccagggaagg gtatggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180 163920·序列表.d〇c •420·
201245225 gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa catgctgtat ctgcaaatga acagcctgcg tgccgaggac accicggcat attactgtgc gaaagagccg cttaggtttg gctactgggg tcagggtacc ctgitcaccg tctcgagc <210> 890 <211> 348 <212> 1M <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 890 gaggtgcagc tgttggattc tgggggaggc ttg；>tacagc ctggggggtc actgcgtctc tcctgigcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct ccagggaagg gtctggagtg ggtctcaict atttcgggta atggtgctaa tacatactac gcagactccg tgaagggccg gttcaccatc tccogcgaca attccaagaa cacgctgtat ctacaaatga acagcctgcg tgccgaggac accjjcggtat altactgtgc gaaagagccg cttaggtttg actactgggg tcggggaacc ctgutcaccg tctcgagc <210> 891-<211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述··合成聚核苷酸 240 300 348 60 120 180 240 300 348 <400> 891 gaggtgcagc tcctgtgcag ccagggaaga gcagactccg ctgcaaatga cttaggtaig tgttggggtc cctccggatt gtctggagtg tgaagggccg acagcctgcg acgactgggg agggggaggc cacctttact ggtctcatct gttcaccatc tgccgaggac tcagggaacc ttg]*tacagc gagtatgaga atticgggta tccogcgaca accgcggtat ctgutcaccg ctggggggtc tgatttgggt atggtgctaa attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaagagccg 60 120 180 240 300 348
<210> 892 <211> 348 <212> WK <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 348 <400> 892 gaggtgcagc tcctgttcag ccagggaagg gcagactccg ctgcaaatga cttaggtttg cgttggagtc cctccggatt gtctggagtg tgaagggccg acagcctgcg actactgggg tgggggaggc cacctttaat ggtctcatct gttcaccatc tgccgaggac tcagggaacc ttg：>tacagc gagtatgaga atttcgggta tccogcgaca acc；5cggtat ctg；;tcaccg ctggggggtc tgatttgggt atggtgctaa attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaagagccg -421 - 163920·序列表.doc 201245225 <210> 893 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 893 gaggtgcagc tgttggagtc tgggsaaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gagtatgaga tgatttgggt ccgccaggct 120 ccagggaaag gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctscg tgccgaggac accgcggtat attactgtgc gaaagagccg 300 cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 894 <211> 348 <212> &NIA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 894 gaggtgcagc tgttggaccc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagtctgaga tgatttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgggaa atggtgctaa tacatactac 180 gcggactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcccgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300 cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 895 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 895 gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgcaaggct 120 ccagggaagg gtatfigagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tcccgaggac accgcggtat attactgtgc gaaagagccg 300 cttaggtttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 896 <211> 348 <212> DNA <213>人工序列 163920·序列表.doc 422- 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 896 gaggtgcagc tgttggagtc tggggtaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgcaaggcc 120 ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaaccg 300 cttaggtttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 897 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
gaggtgcagt tgttggagtc tcggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 (cctgtgcag cctccggatt cacctttact gagcatgaga tgatttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgggta aLggtgctaa tacatactac 180 gcagactccg tgaagggccg gttctccgtc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300 cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 898 <211> 348 <212> C^A <213>人工序列 <220> <M3>人工序列之描述：合成聚核苷酸 <400> 898 gaggtgcagc cgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgctg cctccggatt cacctuact gagtatgaga tgatttgggt ccgccaggct 120 ccagggaagg gtciggagtg ggtcicatct atttcgggta atggtgctaa tacatactac 180 gcagactccg tgaagggccs gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300 cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 899 <211> 348 <212> DNA <^13>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 899 -423- 163920-序列表,doc 201245225 gaggtgcagc tgttggagtc tgcgggaggc ttggtacagc ctgggeggcc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gagtatgaga tgatttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatca atttc^ggta atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccaic tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300 cttaggtttg actactgggg tcagggagcc ctggtcaccg tctcgagc 348 <210> 900 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 900 gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctggggggtc gctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct 120 ccagggaagg gtclggastg ggtctcatct atttcgggta atggtgctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300 cttagging acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 901 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 901 gaggtgcagc tgttggagtc tgggggaggc itggtacagc ctggggggtc tctgcgtctc 60 tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggictcaggt attagtagac gtggttttac tacatactac 180 gcagaclccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg atttgaggta tgcgcgtttt gactactcgg gtcagggaac cctggtcacc 360 gtctcgagc 369
<210> 902 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 902 gaggagcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cct£cstctc 60 tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 】63920·序列表.d〇c -424- 201245225 ccagggaagg gtciagagtg ggtctcaggt at:agtagac gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg ctacgaggta cgcgcgtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 903 <211> 369 <212> DNA <213：>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 903
gaggtgcagc tgttggagtc tgggggaggc ttjigtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat ati：tatgaga tstcgtgggt ccgccagect 120 ccagggaagg gtctagagtg ggtctcaggt atlagtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca atttcaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg atatgaggta tgcgcgtttt gactacgggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 904 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 904
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagtaggc giggtcttac tacatactac 180 gcagactccg tgaagggccg gucaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg atatgaggta tgcgcgtttt gacaactggg gtcagggaac cctggtcacc 360 gtctcgaac 369 <210> 90S <211> 369 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 905 gaggtgcagc tgttggagtc tgggggaggc ttegtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat acgtatgaga tgtcgtgggt ccgccaggct 120 163920·序列表.doc 425 - 201245225 ccagsgaagg gtctagagtg ggtctcaggt attggtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccs gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacstatg atttgaggta tgcgcgtitt gactactcgg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 906 <211> 369 <212> WW <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 906 gaggtgcagc tgatggagtc agggggaggc ttggtacagc clggggggtc cctgcgtctc 60 tcctgtacag cctccggatt ctcctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 ccagggaaag gtctagagtg ggtctcaggt attagtaggc gtggttatac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccs 300 attacitatg atatgag£ta tgcgcgutt gactactggg gtcggggaac cctggtcacc 360 gtctcgagc 369
<210> 907 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 907 gaggtgcagc tgttggagtc tgggggaggc ngglgcagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cgcctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gactagagtg ggtctcaggt attagtaggc atggttttac tacgtactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg atatgcggta tgcgcgttct gactactggg glcagggaac cctggtcacc 360 gtctcgagc 369
<210> 908 <211> 369 <212> DNA <213〉人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 908 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc clggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 163920-序列表.doc •426· 201245225 ccagggaagg gtctagagtg ggtctcaggt attagtaggc glggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atttctglgc gaaagagccg 300 attacgtatg atatgaggta tgcgcgttct gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 909 <221> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷 <400> 909
gaggigcagc tgttggagtc tggggggggc tlsgttcagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccgggtt cacctttaat at；>tatgaga tgtcgtmt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcxgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatt ctatgaggta tgcgcgtttt ga>:tactcge gtctgggaac catg£tcacc 360 gtctcgagc 369 <210> 910 <211> 369 <212> WA <213>人工序列 <220> <223>人工序列之描述•合成聚核苷醚 <400> 910
gaggtgcagc tgctggagtc tgggggaggc tt：>gtacagc ctggggggtc ccttcgtctc 60 tcctgtacag cctccggatt caccttlaat atj^tatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt at:agtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc toxgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcs tgccgaggat aci;gcgetat attactgtgc gaaagagccg 300 attacgtatg atatgaggta tgcgcgtttt ga<uacagtg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 911 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷駔 <400> 911 gaggtgcagc tgttggagtc tsgaggaggc tt^tacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat atjnatgaga tgtcgtgggt ccgcaaggct 120 163920·序列表.doc -427- 201245225 ccagggaags gtctagagtg ggtctcaggt attagtaggc atggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg atatgaggta tgcgcgtttt gaccactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 912 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 912 gaggtgcagc tgtlcgagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaggagccg 300 attacgtatg atatgaggta tgcgcgtttt gactactggg gicggggaac cctggtcacc 360 gtctcgagc 369
<210> 913 <211> 369 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 913 gaggtgcagc tgitggagtc tgggggaggc ttggtacagc ctgggggatc cctgcgtctc 60 tcctgtacag cctccggttt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attact^tgc saaagagccg 300 attacgtatg atatgaggta 丨gcgcgtttt gactactggg gtcggggaac cctggtcacc 360 gtctcgagc 369
<210> 914 <211> 369 <212> dm <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 914 gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt ctcctttaat atgtatgaga tgtcstgggt ccgccasgct 120 163920·序列表.doc •428. 201245225 ccagggaagg gtctagagtg ggtctcaggt ai tagtaggc gtggtutac tacaiactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg aiatgaggta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgggc 369 <210> 915 <211> 369 <212> DNA <2Π>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 915
gaggtgcagc tgttggagtc tgggggaggc tt：|gtacaac ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttaat atjstatgaga tgtcgtgggt ccgcaaggct 120 ccagggaagg gtctagagtg ggtctcaggt at;agtaggc gtggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300 attacgtatg atatga&gta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 916 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 916
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg cgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctgitcaccg tctcgagc 348 <210> 917 <211> 348 <212> DNA <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 917 gaggtgcagc tgttggagtc tgggggaggc ttgjitacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gatutgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attiiatccgc agggtacgcg tacatactac 180 163920-序列表.doc •429- 201245225 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 918 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 918 gaggtgcagc tgttggagtc tgg£ggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgcagaggat accgcggtat attactgtac gaaacttccg 300 tttatttttg aaiactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 919 <21l> 348 <212> DNA <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 919 gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctctcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggiacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attacigtgc gaaacttccg 300 tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 920 <211> 348 <212> DNA <2】3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 920 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattaigaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggiacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaactucg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 163920·序列表.doc -430- 201245225 <2i0> 921 <211> 348 <212> DMA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 921 gaggtgcagc tcctgtgcag ccagggaa£g gcagactccg ctgcaaatga tttattittg tgctggagtc cctccggatt gtctagagcg tgaagggccg acagcctgcg acaaccgggg tgggggaggc ctcctttcgg ggtctcagct gucaccatc tgccgaggat tcagggaacc trggtacagc gjittatgaga ai taatccgc tcccgcgaca accgcggtat ctggtcaccg ctggggggtc tgtggtggta agggtacgcg attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct tacatattac cacgctgtat gaaacttccg 60 120 180 240 300 348
<210> 922 <211> 348 <212> DMA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醍 <400> 922 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttatttttg tgttggagtc tgggggaggc cctccggatt cacctttcgg gtctagagc^ ggtctcagct tgaagggccg gitcaccatc acagcctgcg tgccgaggat scgactgggg tccgggaacc ttggtacagc ctggggggtc cctgcgtctc gattatgaga tgtggtgggt ccgccaggct attaatccgc agggtacgcg tacatactac tc:cgcgaca attccaagaa cacgctgtat ac:tcggtat atcactgtgc gaaacctccg ctigtcaccg tctcgagc 60 120 180 240 300 348 <210> 923 <211> 348 <212> DNA <213>人工序列 <220>
<223>人工序列之描述：合成聚核苷酸 <400> 923 60 120 180 240 300 348 gaggtgcagc tgttggagtc tgggggaggc itugtacagc ctggggggtc ccggcgtctc tcctgtgcag cctccggatt cacctttcgg gauatgaga tgtggtgggt ccgccaggct ccggggaagg gtctagagcg ggtctcagct atv.aatccgc agggtacgcg tacatactac gcagactccg tgaagggccg gttcacgatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat acc:gcggtat attactgtgc gaaacttccg tttacttttg aggactgggg tcagggaacc ctiigtcaccg tctcgagc <210> 924 <211> 348 <212> DNA <213>人工序列 431 · 163920-序列表.doc 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 924 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat actgcggtat attact£tgc gaaacttccg 300 tttatgtttg acgaccgggg tcamaacc ctggtcaccg tctcgagc 348 <210> 925 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 925 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctscstctc 60 tcctgtgcag cctccggatt c&cctttcgg gattatgaga tgtsgtgggt ccgccaggct 120 ccagggaagg tictagagcg ggtctcagct attaatccgc agggtacgcg tacatacuc 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300 tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 926 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 926 gaggtgcagc tgttggagtc tgggggaggc ttg£tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg agccgaggat actgcggtat attactgtgc gaaacttccg 300 tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 927 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 927 gaggtgcagc tgttggagtc tgggggasgc ttgatacagc ctsgsgggtc cctgcgtcic 60 163920-序列表.doc •432· 201245225 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct atlaatccgc agggtacgcg tacatactac 180 gcasactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgttt gaaacttccg 300 tUattttcg actactgggg tcagggaacc ctiigtcaccg tctcgagc 348 <210> 928 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 928
gaggtgcagc tgttggagtc tgggggaggc ttigtacagc ctggggggtc cctgcgtcta 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaacccgc agggtacgcg tacatactat 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgatgat accgcggtat atcactgtac gaaacttccg 300 tttatttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 929 <211> 348 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 929
gaggtgcagc tgttggagtc tgggggaggc ttgj!tacagc ctggggggtc (Xtgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gatnatgaga tgtggtgggt ccgccaggct 120 ccagggatgg ttctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctatat 240 ctgcaaatga acagcctgcg tgccgaggat acc^icggtat attactgtgc gaaacttccg 300 utttttttg actccagggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 930 <211> 34g <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 930 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccgggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920·序列表.doc -433 - 201245225 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgaec 348 <210> 931 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 931 gaggtgcagc tgtlggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc aggstacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 932 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 932
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctstgcag cctccggatt ctccttlcgg gattatgaga tgtggtggta ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatattac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg 丨cagggaacc ctggtcaccg tctcgagc 348 <210> 933 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述··合成聚核苷酸 <400> 933
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg ttctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg 丨gaagggccg gttcaccatc tcccgcgaba attccaagaa catgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 163920-序列表.doc •434· 201245225 <210> 934 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 934 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttacttttg tgttggagtc cctccggatt gtctagagcg tgaagggccg acagcctgcg aggactgggg tgggggaggc cacctttcgg ggtctcagct gttcaccatc tgccgaggat ccagggaacc ttggtacagc gattatgaga attaatccgc tcccgcgaca accgcggtat ctggtcaccg ctggggggtc tgtggtgggt agggtacgcg attccaagaa atcactgLgc tctcgagc cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaacttccg 60 120 180 240 300 348 <210> 935 <211> 348 <212> Wh <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 935 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggatt cacctttcgg ccagggaagg gtctagagcg ggtctcagct gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggat tttacttttg aggactgggg tcagggaacc tt.sgtacagc ctggggggtc cctgcgtctc gattatgaga tgtggtgggt ccgccaggct attaatccgc agggtacgcg tacacaciac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtac gaaacttccg ctjigtcaccg tctcgagc <210> 936 <2U> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 936 gaggtgcagc tgttggagtc tgggggaggc ttygtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgttt gaaacttccg tttacttttg aggactgggg tcagggaacc ct|；gtcaccg tctcgagc <210> 937 <211> 348 <212> DNA <213>人工序列 <220> 163920·序列表.doc -435· 60 120 180 240 300 348 60 120 180 240 300 348 201245225 <223>人工序列之描述：合成聚核苷酸 <400> 937 gaggtscagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaacccgc agggtacgcg tacatactat 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgatgat accgcggtat atcactgtac gaaacttccg 300 tttatttttg aatactggee tcagggaacc ctggtcaccg tctcgagc 348 <210> 938 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 938 gaggtgcagc tgttggagtc tggsggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgatgggccg ettcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat aitactgtgc gaaagaacct 300 tatagttttg actcctgggg tcagggaacc ctggicaccg tctcgagc 348
<210> 939 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述··合成聚核苷酸 <400> 939 gagstgcagc tgttggagtc tggggsaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgatgggccg gticaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaagaacct 300 tatagltalg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 940 <21l> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 940 gaggtgcagc tgttggagtc tgggggaggc ttggtacaac ctggggggtc cctgcgtctc 60 163920-序列表.doc -436· 201245225 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccgggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggiacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 941 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 941
gaggtgcagc tgttggagtc tgggggaggc tti>£tacagc ctggggggtc cctgcgtcta 60 tcctgtgcag cctccggatt cacctttcgg ga:tatgaga tgtggtgggt ccgccgggct 120 ccagggaagg gtctagagcg ggtctcagct at:aatccgc agggtacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgagsat acv.gcggtat attactgtgc gaaacttccg 300 tctatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 942 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 942
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtcicagcl attaatccgc agggtacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300 tttatgtttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 943 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 943 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac ISO gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920-序列表.doc •437- 201245225 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 944 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 944 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacclttgct gggtatgagt tgtggtgggt ccgccaggct 120 ccagggaagg gtclagagcg ggtclcagct attaatccgc agggtacgcg 丨acatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300 tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 945 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 945
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtaigaga tgtggtggtt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttLtg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 946 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 946
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctitgct gfigtatgaga tgtggtggtt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcs tgccgaggat aclgcggtat attactgtgc gaaacttccg 300 tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 947 163920-序列表.doc •438- <400〉 947 gaggtgcagc tcctgtgcag cca£ggaagg gcagactccg ctgcaaatga tttacttUg 201245225 <211> 348 <212> DNA <21?>人工序列 <220> <223>人工序列之描述：合成聚核苷狻 tgttggagtc tgggggaggc uggtacagc ctggggggtc cctgcgtctc cctccggatt cacctttcgg giittat^aga tgtggtgggc ccgccaggct gtcta£a£tg 2gtctcagct aitaatccgc agggtacgcg tacatactac tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg acgactgggg tcagggaacc ctggtcaccg tctcgagc <210> 948 <211> 348 <212> 腕 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷毗 60 120 180 240 300 348
<400> 948 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttatgmg tgttggagtc cctccggatt gtctagagtg tgatgggccg acagcctgcg acgaccgggg tgggggaggc cacctttcgg ggtctcagct gttcaccatc tgccgaggat tcagggaacc
Uggtacagc gattatgaga at:aatccgc tcccgcgaca act.gcggtat ctiigtcaccg ctggggggtc tgtggtgggt agggtacgcg attccaagaa attactgtgc tctcgagc cctgcgtcta ccgccaggct tacatactac cacgctgtat gaaacttccg 60 120 180 240 300 348 <210> 949 <211> 348 <212> Wk <213>人工序列 <220>
<223>人工序列之描述：合成聚核苷敗 <400> 949 60 120 180 240 300 348 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagaficg ggtctcagct attaatccgc agggtacgcg tacatactac gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat ctgcaaatia acagcctgcg tgccgaggac acc.?cggtat attactgtgc gaaacttccg acctacutt ccgaccgggg tcagggaacc ctgjitcaccg tctcgagc <210> 950 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 •439· 163920·序列表.d〇c 201245225 <400> 950 gaggtgcagc tgtt^sagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtciagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttttctttg aggagtgggg tcagggaacc ctggtcaccg tctcgasc 348 <210> 951 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 951 gaggtgcagc tsttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tglsgtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 acgtacttta aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 952 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 952 gaggtgcagc tgttggagtc tgg£g£aggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttt ccgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 953 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 953 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccutcgg gatlatgaga tgtggtgggt ccgccaggct 120 163920-序列表.doc •440· 201245225 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg 丨gaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tsccgaggac accgcggtat atcactgtgc gaaacttccg 300 atgitctttg aggactgggg tcagggaacc ctggtcaccg tctcgaac 348 <210> 954 <211> 348 <212> DNA <2i3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 954
gaggtgcagc tgttggagtc tgggggaggc ttiigtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg ga:tatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct atr.aatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttccgtttt cggagtgggg tcagggaacc ctggtcaccg tctcgagc 348 9SS <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 955
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattat£aga tgtggtgegt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatgg acagcctgcg tgccgaggac accgcgglat attactgtgc gaaacttccg 300 ttttactttt ccgagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 956 <211> 348 <212> DKA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 956 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtaacct cacatactac ISO gcagaciccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accucggtat attactgtgc gaaacttccg 300 163920·序列表.doc •441 · 201245225 tttacttttg aggacigggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 957 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 957 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggggstc cctgcgictc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc ccggtacctt gacataclac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 958 <21]> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 958 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctsgggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggigggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtggctt gacatactac ]80 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 959 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 959
gaggtgcagc tgttggagtc tggggeaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctltcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccga tgggtgggtt cacatactac 180 gcagactccg (gaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctecg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 960 <211> 348 163920-序列表.doc 442· 201245225 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 960 gaggtgcagc tcctgtgcas ccagggaagg gcagactccg ctgcaaatga tttacttttg tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct gtctagagcg £gtctcagcc attaatccgt ggggttcgca cacatactac tfiaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcclgcg tgccgaggat accgcggtat attactgtgc gaaacttccg aggactgggg tcagggaacc ctggtcaccg tctcgagc <210> 961 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醚 <400> 961 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttacttttg tfittggagtc tgggggaggc ttugtacagc ctggggggtc cctgcgtctc cctccggatt cacctttcgg ga:tatgaga tgtggtgggt ccgccaggct gtctagagcg ggtctcagct atr.aatccgt ccggtgggct gacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggat accgcggtat attactgtsc gaaacttccg acgaccgggg tcagggaacc ctggtcaccg tctcgagc <210> 962 <211> 348 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷毗
<400〉 962 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc acggttcgtt gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcgetat attactgtgc gaaacttccg tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc <210> 963 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc • 443 - 201245225 <40Q> 963 gaggtgcagc tgttggagtc tgggggagsc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gatlatgaga igtggtgggt ccgccaggct 120 ccagggaagg stctagagcg ggtctcagct attaatccgg ccggtcggtt gacatactac 180 gcagactccs tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 964 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 964
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggggstc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaaee gtctagagcg ggtctcagct attaatccgt ggggtagctt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttug aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 965 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 965
gaggtgcagc tgttggagtc tggsggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccc gactacgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 966 <21]> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 966 gaggtgcagc tgttggagtc tggmaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag actccggatt cacctttccg cccgtggaga tgtggtgggt ccgccaggct 120 444- 163920·序列表.doc 201245225 ccagggaagg gtctagagcg ggtctcagct atlaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 967 <211> 348 <212> DNA 人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 967
gaggtgcagc tgttggagtc tgggggaggc ttgitacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtgggct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcc:gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctgitcaccg tctcgagc 348 <210> 968 <211> 348 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醆 <400> 968
gaggtgcagc tgttggagtc tgggggaggc ttgitacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtaacca cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 969 <211> 348 <212> DNA <2】3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 969 gaggtgcagc tgttggagtc tgggggaggc ttgitacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct att.iatccgc acggtggcta cacatactac ISO gcagactccg tgaagggccg gttcaccatc tcc>;gcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 163920·序列表.doc -445- 201245225 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <21Q> 970 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 970 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggsggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaggg gtctagagcg ggtctcagct attaatccgc ccggiatgct cacatactac 180 gcagactccg t^aagfgccg gttcaccatc tcccgcgaca attocaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 971 <21I> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 971 gaggtgcagc tgttggagtc tggggia£gc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtcastt gacatactac 180 gcagactccg tgaagggccs gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggicaccg tctcgagc 348 <210> 972 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 972
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtggcta cacatactac 180 gcagactccg tgaagggccg attcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg igccgasgat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 973 <211> 348 <212> DNA 163920-序列表.doc 446 - 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷齪 <400> 973 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgt cgggtgggct gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcclgcg tgccgaggat accgcggtat attactgtgc gaaacttccg tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348
<210> 974 <211> 348 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 974 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctltcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct att.iatccgt cgggtgggtt gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat acci»cggtat attactgtgc gaaacttccg tttacttttg acgactgggg tcagggaacc ctgiucaccg tctcgagc 60 120 180 240 300 348 <210> 975 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 975 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attnatccgt cgggtacgct cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accv.cggtat attactgtgc gaaacttccg tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348 <210> 976 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920·序列表.d〇c -447- 201245225 <400> 976 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaasg gtctagagcg ggtctcagct attaatccgt acggttcgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 Utactittg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 977 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 977 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaaucgt ggggtggcta cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 978 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 978 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt.cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtgggct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttus aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 979 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 979 gaggtgcagc tgttggagtc tgggg£&ggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgt£gtg£gt ccgccagfct 120 ccagggaagg gtctagagcg ggtctcagc丨 attaatccgt ggggttccca cacatactac 180 163920·序列表.doc •448- 240201245225 gcagactccg tgaagggccg gttcaccatc Lcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcsgtat attactgtgc gaaacttccg tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 300 348 <210> 980 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃
<400> 980 gaggtgcagc tgttggagtc tgggggaggc tt.igtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg stctagagcg ggtctcagct at^aatccgt ggggtacctt gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg tttacttttg acgactgggg tcagggaacc cti：gtcaccg tctcgagc <210〉 981 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 348 <400> 981 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt caccutcgg gattatgaga tstggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccga acggtcggct gacatactac gcagactccg tgaagggccg gtlcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg tttacttttg cggactgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348
<210> 982 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 982 gaggtgcagc tgttggagtc tgggggaggc ttg^tacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctltcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct att.iatccgt ggggtcagct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctgirtcaccg tctcgagc 348 163920·序列表.doc •449- 201245225 <210> 983 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 983 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 ccctetgcag cctccggatt cacctttcgg gatcatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcs ggtctcagct attaatccgc acggtggcct cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgc^aca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttactttts acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 984 <211> 348 <212> IM <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 9S4 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctggagcg ggtctcagct attaatccgg cgggtatgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 985 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 985 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcas cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc acggtacctt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acaecctgc£ tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 986 <211> 348 <212> DNA <2】3>人工序列 163920-序列表.doc 450- 201245225 <220> <223>人工序列之描述•·合成聚核苷酸 <400> 986 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctstgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtxcgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat a<:cgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 987 <211> 348 <212> im <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃
gaggtgcagc tgttggagtc tgggggaggc tiggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct aitaatccgt acggtggcct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 酸 核 聚 成 合 描 之 列?· 冬序 88 A工 工- 9834DN人 人 0>1>2>3>0>3> 11 1L 11 1 ΤΛ ΟΛ <2<2<2<2<2<2 <400> 988 Eaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttacttttg tgttfigagtc tgggggaEgc ttggtacagc ctggggggtc cctgcgtctc 60 cctccggatt cacctttcgg gattacgaga tgtggtgggt ccgccaggct 120 gtctagagcg ggtctcagct attaatccgg ccggtttctt gacatactac 180 tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 989 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 989 451 - 163920-序列表.doc 201245225 gaggtgcagc tgttggagtc tgggggaggc ttggtacggc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctggagcg ggtctcagct attaatccgt acggtggcct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttltg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 990 <211> 348 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 990
gaggtgcagc tgttggagtc tgggggaggc ttggtacaec ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccaggsaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180 gcagactccg igaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat auactgtgc gaaacttccg 300 tttactttcg aggactgggg tcasggaacc ctggtcaccg tctcgagc 348 <210> 991 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 991
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggggstc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaage gtctagagcg ggtctcagct attaatccgt ggegtgggtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 992 <211> 348 <2I2> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 992 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagascg ggtctcagct attaatccgt acggtgggct gacatactac 180 -452- 163920-序列表.doc
201245225 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatgg acagcctgcg tgccgaggat ai：cgcggtat attactgtgc naaacttccg tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc <210> 993 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 993 gaggtgcagc tgttfigagtc tgggEfiaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct altaatccgt ggggtacgtt gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg tttacttcig aggactgggg tcagggaacc clggtcaccg tctcgagc <210> 994 <211> m <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷瞍 240 300 348 60 120 180 240 300 348 <400> 994 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttacttttg tgttggagtc cctccggatt gtctagagcg tgaagggccg acagcctgcg Qggactgggg tgggggaggc cacctttcgg ggtctcagct gucaccatc tgccgaggat tcggggaacc ttggtacagc gattatgaga attaatccgt tcccgcgaca accgcggtat ctggtcaccg ctggggggtc tgtggtgggt ggg£tggcta attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct cacatactac cacgctgtat gaaacttccg 60 120 180 240 300 348
<210> 995 <211> 348 <212> IM <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 995 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtaacct gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 163920-序列表.doc 60 120 180 240 300 348 •453 - 201245225
<210> 996 <2Π> 348 <212> DNA Ο13》人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 996 gaggtgcagc tgttggagtc tgggggaggc Itggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gatiatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc acggtgggtt cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactetgc gaaacttccg tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348 <210> 997 <211> 348 <2I2> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 997 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttactttig tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcstctc cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct gtctagagcg ggtctcagct attaatccgg ccggtttcta cacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat aca^cctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg acgactgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348 <210> 998 <21]> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 998 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttacttttg tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct gtctagagcg ggtctcagct attaatccgg cgggtggcct cacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg 〖gccgaggat accgcggtat attactgtgc gaaacttccg acgactgggg 〖cagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348 <210> 999 <211> 348 <212> DNA <213>人工序列 163920.序列表.doc 454- 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 999 gaggtgcagc tgttggagtc tgggggaggc ti.ggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cgcctttcgg gattatgaga tgtggtgggt ccgccaggcl 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc acggttccct cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttactlttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1000 <21】> 348 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷瞍
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt gattatgaga tgtggtgggt ccgccaggct 120 ccagsgaagg gtctagagcg ggtctcagct attaatccgg ccggtgggta cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300 tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1001 <211> 348 <212> mk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醍
<400> 1001 gaggtgcagc tcctgtgcag ccagggaagg gcagactcc£ ctgcaaatga ttttggttta tgttggagtc cctccggatt gtctagagcg tgaagggccg acagcctgcg cggagtgggg tgggggaggc cacctttcgg ggtctcagct gttcaccatc tgccgaggac tcagggaacc tt.igtacagc gattatgaga at taatccgc tcccgcgaca accgcggtat ctggtcaccg
Ctggggggtc tgtggtgggt agggtacgcg attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaacttccg 60 120 180 240 300 348 <210> 1002 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酕 <400> 1002 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 455 · 163920·序列表.doc 201245225 tcctgtgcas cctccggatt cacctttcgg gattalgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 ttcatgtttt ccgaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <2I0> 1003 <211> 348 <212> ΚΊΑ <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1003 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 ccctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac ISO gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttttgtttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1004 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1004 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 acgcggtttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1005 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1005 gaggtgcagc tgitggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct atiaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccalc tcccgcgaca attccaagaa cacgclgtai 240 163920-序列表.doc •456- 201245225 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 300 348 <210> 1006 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷瞍
<400> 1006 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc <210> 1007 <21l> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷齪 60 120 180 240 300 348 <400> 1007 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac gcagactccg tgaagggccg sttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg acgttcttta aggactgsgg tcasgsaacc ctngtcaccg tctcgagc 60 120 180 240 300 348
<210> 1008 <211> 348 <212> DNA <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1008 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga tttttctttc tgttggagtc cctccggatt gtctagagcg tgaagggccg acagcctgcg agmtgggg tgggggaggc cacctttcgg ggtctcagct gttcaccatc tgccgaggat tcagggaacc ttjigtacagc gauatgaga attaatccgc tcccgcgaca accgcggtat ctggtcaccg
Ctggggggtc tgtggtgggt agfigtacacg attccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaacttccg 60 120 180 240 300 348 •457- 163920·序列表.doc 201245225 <2i0> 1009 <211> 348 <212> K^A <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1009 gaggtgcagc tgttggagic tgggggaggc ttggtacagc ctgggg£gtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 cagttgttlc acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1010 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1010 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 cagctctttg a8gactgm tcagggaacc ctggtcaccg tctcgagc 348 <210> 1011 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1011 gaggtgcagc tsttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtcta^agcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300 tttgggtttt ccgagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1012 <211> 348 <212> DNA <213>人工序列 <220> 163920·序列表.doc 458· 201245225 <223>人工序列之描述：合成聚核苷睃 <400> 1012 gaggtgcagc tgttggagtc tgggggaggc tiggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gz.ttatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc aggglacgcg tacalaciac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 cagttgtttc aggactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1013 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1013
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac ac:gcggtat attactgtgc gaaacttccg 300 tttttctttc acgagtgggg tcagggaacc ctigtcaccg tctcgagc 348 <210> 1014 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之指述··合成聚核苷醚 <400> 1014
gaggtgcagc tgttggagtc tgggggaggc ttijgtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg g(tcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acogcggtat attactgtgc gaaacttccg 300 cactacttta aggactgggg tcagggaacc cti>gtcaccg tctcgagc 348 <210> 1015 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1015 gaggtgcagc tgttggagtc tgggggaggc ttngtacagt ctggggggtc cctgcgtctc 60 163920·序列表,doc -459- 201245225 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 ttttactttg aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1016 <211> 348 <212> DNA <213>人工序列 <22Q> <223>人工序列之描述：合成聚核苷酸 <400> 1016 gaggtgcagc tgltggagtc tgggggaggc 〖tggtacagc ctggggggtc cc丨gcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttaggtttt ccgaccgggg tcagggaacc ctg£tcaccg tctcgagc 348
<210> 1017 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1017 gaggtgcagc t£ttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac ISO gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 acgctgtttc aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1018 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1018 gaggtgcagc tgttggagtc tggsgg^ggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatcc£c agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920·序列表.doc -460- 300 201245225 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg ttttactttt ccgagtgggg tcagggaacc ctggtcaccg tctcgaac <210> 1019 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷骏 348 <400> 1019 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga ttttggtttc ^ttggagtc cctccggatt gtctagagcg tgaagggccg acagcctgcg aggagtgggg tgggggaggc cacctttcgg ggtctcagct gttcaccatc tgccgaggac tcagggaacc tiggtacagc gattatgaga ar.taatccgc tcccgcgaca accgcggtat clggtcaccg ctggggggtc tgtggtgggt agggtacgcg atlccaagaa attactgtgc tctcgagc cctgcgtctc ccgccaggct tacatactac cacgctgtat gaaacttccg 60 120 180 240 300 348
<2!0> 1020 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1020 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga mtactttc tgttggagtc tgggggaggc cctccggatt cacctttcgg gtctagagcg ggtctcagct igaagggccg gttcaccatc acagcctgcg tgccgaggac aggagtgggg tcagggaacc ttggtacagc ctggggggtc cctgcgtctc gattatgaga tgtggtgggt ccgccaggct attaatccgt ggggttcgtt gacatactac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gaaacttccg ctggtcaccg tctcgagc 60 120 180 240 300 348
<210> 1021 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1021 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc, tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat ac:gcggtat atcactgtgc gaaacttccg atgttctttg aggactgggg tcagggaacc ctggtcaccg tctcgaac <210> 1022 163920·序列表.doc 60 120 180 240 300 348 -461 - 201245225 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1022 gaggtgcagc tgttggastc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg eattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg sgtctcagct attaatccst ggggttcgtt gacataciac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc acgagtggsg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1023 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1023 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg eattatgaga t£tggtgggi ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac ]80 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acascctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttttctttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1024 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1024 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttttctttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1025 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc -462- 201245225 <4〇〇> 1025 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg g.ittatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtciagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180 gcagactccg tgaagggccg gttcaccatc toccgcgaca attccaagaa cacgctgtat 240 dgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 ctttactttc aggagtgggg tcagggaacc c:gglcaccg tctcgagc 348 <210> 1026 <211> 348 <212> DNA <2】3>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1026
gaggtgcagc tgttggagtc tgggggaggc tiggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg giitiatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacsctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300 atgttctttg aggactgggg tcagggaacc ciggtcaccg tctcgaac 348 <210> 1027 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1027
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gactatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg gglctcagct attaatccgt ggggtgggtt cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1028 <211> 348 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <4Q0> 1028 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 163920-序列表.d〇c •463 · 201245225 ccagggaagg gtctaeagce ggtctcagct attaatccgt ggggtgggtt cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctKcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 tttttctttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1029 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1029 gaggtgcagc tgltggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 clgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300 tttttctttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348 列 序 308JA工 1034i 人 0>1>2>3> <21<21<21<21 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1030 gaggtgcagc tgttggagtc igggggaggc ttggtacagc ctggggggtc cctgcgtcic 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgl ggggtgggtt gacatactac 180 gcagactccg t^aagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg igccgaggat accgcggtat altactgtgc gaaacttccg 300 ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1031 <211> 348 <212> DNA <213>人工序列 <220> <223>人土序列之描述：合成聚核苷酸
<40Q> 1031 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctaeagcg ggtctcagct attaatccgl ggggtgggtt gacatactac 180 gcagactccg tgaaggcccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaactlcce 300 163920·序列表 _doc -464- 201245225 atgttctttg aggactgggg tcagggaacc ctggtcaccg tctcgaac <210> 1032 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷i後 <400> 1032 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc
<210> 1033 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1033 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat ac:gcggtat attactgtgc gaaacttccg tttttctttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc <210> 1034 <211> 348 <212> DNA <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1034 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccg£att cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaags gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac gcagactccg tgaagggccg gttcaccatc tc:cgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat ac:gcggtat attactgtgc gaaacttccg tttttctttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc <210> 1035 <211> 348 -465- 163920·序列表.doc 201245225 <212> DNA 人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1035 gaggtgcagc tgttggagtc tgg£ggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaeect 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca aitccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtal atcactgtgc gaaacttccg 300 atgttctttg aggactgggg tcagggaacc ctggtcaccg tctccagc 348 <210> 1036 <211> 357 <212> MW <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1036
gaggtgcagc tgttggagac tgggggaggc ttggtacagc ctgggggstc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg acttatcata tgcagtgggt ccgccgggct 120 ccagggaagg gcctggagtg ggtctcaatg attgatgcgg atggtcttgg gacatactac 180 gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccaaggac accgcggtat attactgtgc gagaccgggt 300 ccgcagtttg gtcagtttga ctacttgg£t cagggaaccc tggtcaccgt ctcgagc 357 <210> 1037 <211> 3S7 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1037 gaggtgcagc tgtttgagtc teggggaggc ttgKtacaga ctggsgggtc cctgcgtctc 60 tcct£t£cag cctccggatt caccttttce acttatcata tgcagtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaatg atlgatgcgg atggtcttgg gaaatactac 180 gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaacc£ggt 300 ccgcagtttg gtcagtatga ctaclggggt cagggaaccc tgfitcaccgt ctcgagc 357
<210> 1038 <211> 363 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表,doc •466- 201245225 <400> 1038 gaggtgcagc tgttggagtc agggggaggc tcggtacagc ctggggggtc cctgcggctc 60 tcctgttcag cttccggatt caccttttcg giigtatgata tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg aftagtgcgt cgggtgttta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcct 300 aatcgttitg cgcttaaiag tmgactac af:gggtcg£g gaaccctggt caccgtctcg 360 age 363 <210> 1039 <211> 363 <212> 腿 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1039
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cttccggatt caccttttcg gggtatgata tgcagtgggt ccgccaggct 120 ccagggaggg gtctagagtg ggtctcaacg attagtgcgt cgggtgttta tacatactac 180 acagactccg tgaagggccg gttcaccacc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtac gaaatatcca 300 aatcgttttg egegtaataa ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 age 363 <210> 1040 <211> 324 <212> DMA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1040
gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120 ggggaagccc ctaagctcct gategagagt tcttccggtt cgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tcigcaacct 240 gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcagccaa 300 gggaccaagg tggaaatcaa aegg 324 <210> 1041 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1041 163920·序列表.doe •467- 201245225 gacatccaga igacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcagacag ttctattttg tgggcgttag cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgagagt tcatccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1042 <211> 324 <212> DMA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1042 gacatccaga tgaccgtgtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcagatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgaga^t tcttccggat tgcafiagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ciacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324
<210> 1043 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1043 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tg£gacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcgaccaa 300 gggaccaagg tggaaatcaa acgg 324
<210> 1044 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1044 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgagagt tctaccggtt tgcaaagtgg ggtcccatca 180 163920-序列表.doc -468- 201245225 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa gggaccaagg tggaaatcaa acgg 240 300 324 <210> 1045 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷狻
<400> 1045 gacatccaga tgaccgtgtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaaatag ttctattttg tnggcgttag cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcgagagt tcttccggat tgcaaagcgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ti:cactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgttcag autgcggttt ggcctggtac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324 <210> 1046 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1046 gacatccaga tgacccagtc tccatcctcc cigtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcagatag ttctattttg tsggcettag cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcgagagt tcttccggit tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac ettcgaccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324
<210> 1047 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1047 gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca gggaaagccc ctgagctcct gatcgagagt tcttccggtc tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324 163920-序列表.doc -469- 201245225 <210> 1048 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1048 gacatccaga igacccagtc tccatcctcc atcacttgcc gggcgaatag ttctatattg gggaaagccc ctaagctcct gatcgagagt cgtttcagcg gcagtggatc tgggacagat gaagattttg ctacgtacta ctgtgttcag gggaccaagg tggaaaacaa acgg <210> 1049 <211> 324 <212> DNA <213>人工序列 <220> ctgtctgcat ctgtaggaga ccgtgtcacc t£ggC£ttgg cttgstacca gcagaaacca tcttccggtt tgcaaagtgg ggtcccatca ttcactctca ccatcagcag tctgcaacct aatgcggttt ggoctggtac gttcggccaa 60 120 180 240 300 324 <223>人工序列之描述：合成聚核苷酸
<400> 1049 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaaatag ttctattctg tgggcgitag cttggtacca gcagaaacct gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca cgtttca^tg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaaccc gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa g£g&ccaagg tggaaatcaa acgg 60 120 180 240 300 324 <210> 1050 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1050 gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctgtaggaga ccgtgtcacc atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg gatcccatca cgtitcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgticag aatgcggttt ggcctggtac gttcggccaa gggaccaagg tggaaatcaa acgg
60 120 180 240 300 324 <210> 1051 <211> 324 <212> DNA <213>人工序列 163920-序列表.doc 470- 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1051 gacatccaga tgacccagic tccatcctcc ctgtctgcat ctgttggaga ccgtgtcacc atcacttgcc gggcaaatag ttctattttg tjjggcgttag cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcgagagt tottccggat tgcaaagcgg ggtcccatca cgUtcagtg gcagtggatc tgggacagat t icactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgttcag antgcggttt ggcctggtac gttcggccaa gggaccaag^ tggaaatcaa acgg 60 120 180 240 300 324 <210> 1052 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1052 gacatcctgt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgigtcacc atcacttgcc gggcaaatag uctattttg tgggcgttag cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagai ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324 <210> 1053 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃
<400> 1053 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaaatag ttctattttg tgggcgUag cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca cgtttcagtg gaagtggaac tgggacagat tt:actctca ccatcagcgg tctgcaacct gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcgaccaa gggaccaagg iggaaatcaa acgg 60 120 180 240 300 324 <210> 1054 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1054 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 163920-序列表.doc -471- 201245225 atcccttgcc gggcaaatas ttctattttg tgggcgttag cttggtacca gcagaaacca 120 gggaaagccc ctaa^ctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtgcatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300 gggaccaagg tggagatcaa acgg 324 <210> 1055 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1055 gacatccaga tggcccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggaic tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac gttaggccaa 300 gggaccaaag tggaaatcaa acgg 324
<210> 1056 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1056 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 ggggaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgccatcag tatgcgagtc caccttigac gttcggccaa 300 gggaccaatg tggaaatcaa acgg 324
<210> 1057 <211> 324 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1057 gacatccaga tgacccagtc tccatcctcc ctatctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcstttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgit tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctecaacct 240 163920-序列表.doc -472- 201245225 gaagattttg ctgcgtacta ctgtcatcag tucgagagtc cacctttgac gtttggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1058 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷瞍 <400> 1058 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg gacgattgag 〇i;tcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcgcgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag utgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324
苷 核 聚 成 合 述 描 之 列 列 序 序 594 A工 工 1032g 人 人 1Λ 1* 1* Ti <400> 1059 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga acgtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattctg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac Etraggccaa 300 gggaccaaag tggaaatcaa acgg 324 DNA 人工序列 <210> 1060 <211> 324 <212> <213> <220> <223>人工序列之描述：合成聚核苷酸 <400> 1060 gacatccaga tgacccagtc tccatcctcc ctstctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagcca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 gsgaafigccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tt:actctca ccatcagcag tctgcaacct 240 gaagatittg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac gttaggccaa 300 gggaccaaag tggaaatcaa acgg 324 •473 · 163920-序列表.doc 201245225 <210> 1061 <2Π> 324 <212> DNA <213>人工序列 <22Q> <223>人工序列之描述：合成聚核苷酸 <400> 1061 gacatccaga taacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca gggaaagacc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca cgtttcastg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag tatgagagtc ctcctttgac gttcggccaa gggaccaaag tggaaatcaa acg£ <210> 1062 <211> 324 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 324
<400> 1062 gacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtca gacgattgag ggggaagccc ctaagctcct gatctatctt cgtttcagtg gcagtggatc tgggacagat gaagattttg ctacgtacta ctgtcatcag gggaccaaag tggaaatcaa atgg <210> 1063 <211> 324 <212> DNA <213>人工序列 <220> ctgtctgcat ctgtaggaga ccgtgtcacc cgtcgtttaa attggtatca gcagaaacca gcucccgtt 〖gcaa时igg ggtcccatca ttcactctca ccatcagcag tctgcaacct tatgagagtc cacctttgac gttcggccaa 60 120 180 240 300 324 <223>人工序列之描述：合成聚核苷酸 <400> 1063 gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc atcacttgcc gggcaagtca gacgattgag cgtcstttaa attggtatca gcagaaacca gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagaa ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg
60 120 180 240 300 324 <210> 1064 <2I1> 324 <212> DNA <213>人工序列 <220> 474· 163920-序列表.d〇c 201245225 <223>人工序列之描述：合成聚核苷後 <400> 1064 gacatccaga tgtcccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcgtuaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgct tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgicatcag tatgagagtc cacctttgat gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1065 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1065
gacatccaga tgacccagtc tccatccicc ct：>tctgcat ctgtaggaga ccglgtcacc 60 attacttgcc gggcaagtca gacgattgag cgccgtttaa attggtatca gcagaaacca 120 gggaaagacc ctaagctcct gatctatctt gcctcccgtt tgcaaagtgg gglcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttoactctca ccatcagcag tctgcaacca 240 gaagattttg ctacgtacta ctgtcatcag ta:gagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1066 <2Π> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述··合成聚核苷醚 <400> 1066 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ccgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgixgtttaa actggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcrtcccgtt tgcaaaglgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tai.gagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1067 <211> 324 <212> DNA <2丨3>人工序列 <220> <223>人工序列之描述：合成聚核苷酕 <400> 1067 gacatccaga tgacccagtc tccatcctcc cti：tttgcat ctgtagggga ccgtgtcacc 60 -475· 163920·序列表.doc 201245225 atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tggsacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattltg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 Sggaccaaag tggaaatcaa acgg 324 <210> 1068 <211> 324 <212> DNA <213;►人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1068 gacatccaga cgacccagta tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtcgattgag cgtcgtttaa attggtatca gcagaaacca 120 ggggaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagactctg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gctcggccaa 300 gggactaaag tggaaatcaa acgg 324
<210> 1069 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1069 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg gacgattgag cglcgttvaa aUggUlca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcgcgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatccg tatgagagtc cacctttgac gttcggccaa 300 Sgsaccaaag tggaaatcaa acgg 324
<210> 1070 <211> 324 <212> jm <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <40Q> 1070 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaastca ggcgattgag cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatct 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcagcca 240 163920·序列表.doc -476- 201245225 gaagattttg ctacgtacta ctgtcatcag latgcgagtc cacctttgac gctcggccaa 300 gggaccaaag tggaaatcaa acgg 324 酸 苷 核 聚 成 合 述 描 之 歹 歹 序 序 714A工 工 1032DN人 人 0>1>2>3>0>3> lull 22 <400> 1071 aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggcgattgag cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttctcgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1072 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1072 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattggg cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt g:ttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggtcagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tutgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1073 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1073 gacatccaga tgacccagtc tccatcctcc ctttctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gagcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gottcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagaa t:tactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1074 -477- 163920·序列表.doc 201245225 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1074 gacatccaga tgacccagac tccatcctcc atcacttgcc gggcaagtca gacgattgag ggggaagccc ctaagctcct gatctatctt cgtttcagtg gcagtggatc t^gaca^at gaagattttg ccacgtacta ctgtcatcag gggaccaaag tgaaaatcaa acgg <210> 1075 <211> 324 <212> DNA <213>人工序列 <220> ctgtctgcat ctgtaggaga ccgtgtcacc cgtcgtttaa attggtatca gcagaaacca gcttcccgtt tgcaaagtgg ggtcccatca ttcactctca ccatcagcag tctecaacct tatgagagtc cacctttgac gttcggccaa 60 120 180 240 300 324 <223>人工序列之描述：合成聚核苷酸
<400> 1075 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagtgtcacc atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca gggaaagccc ctaagctcct s^tctatctt gcttcccgtt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaaccc gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg <210> 1076 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 60 120 180 240 300 324 <400> 1076 cacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtca gacgattgag gggaaagccc ctaagctcct gatctatctt cgtttcagtg gcagtgsatc tgggacagat gaagattttg ctacgtacta ctgccatcag gggaccaaag tggaaatcaa acgg <210> 1077 <211> 324 <212> DNA <213>人工序列 <220> ctgtctgcat ctgtaggaga ccgtgtcacc cgtcgtttaa attggtatca gcagaaacca gcttcccgtt tgcaaagtgg ggtcccatca ttcactctca ccatcagcag tctgcaacct tatgagagtc cacctttgac gttcggccaa 60 120 180 240 300 324
<223>人工序列之描述：合成聚核苷酸 -478 - 163920-序列表.d〇c 201245225 <400> 1077 gacgtccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 ggggaagccc ctaagctcct gatctatctt acttcccgtt tgcaaagcgg ggtcccatca 180 cgtttcagtg gtagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgccatcag tatgcgagtc cacctttgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1078 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1078
gacatccaga tgacccagtc gccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt g:ttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaccag t.Ugagagtc cacctttgac gttcggccaa 300 gggaccaaag tggtaatcaa acgg 324 <210> 1079 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1079
gacatccaga tgacccagtc tccatcctcc cigtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtca gacgattgag cutcgtttaa attggtatca gcagaaacct 120 £ggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcastggatc tgggacagat tr.cactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1080 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1080 gacatccaga tgacccagtc tccatcctcc clgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gccgattgag cgtcgtttaa attggtatca gcagaagcca 120 163920-序列表.doc •479· 201245225 gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacatacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1081 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1081 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattggg cgtcgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324
<210> 1082 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1082 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtcgattgag cgccgtttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc ctcctttgac gttcggccaa 300 gggaccaaag tggaaatcat acgg 324 <210> 1083 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1083 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacct 120 gggaaagccc ctaagctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 163920-序列表.doc •480· 201245225 gggaccaaag tggaaatcaa acgg 324 <210> 1084 <211> 324 <2i2> im <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1084 gacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtca gtcgattgag gggaaagccc ctaagctcct gatctatctt cgtttcagtg gcagtggatc tgggacagat gaagattttg ctacgtacta ctgtcatcag gggaccaaag tggaaatcaa acgg ctgtctgcat ctgtaggaga ccgtgtcacc c£：ccgtttaa attggtatca gcagaaacca gcttcccgtt tgcaaagtgg ggtcccatca ttcactctca ccatcagcag tctgcaacct tatgagagtc ctcctttgac gttcggccaa 60 120 180 240 300 324
<210> 1085 <211> 324 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷iife <400> 1085 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacct gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag ttcgagcacc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg 60 120 180 240 300 324
<210> 1086 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1086 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc atcacttgcc gggcaagttt ccccattgac cgtcgtttaa attggtatca gcagaaacct gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca cgcttcagtg gcagtggatc tgggacagat tt:actctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg 60 120 180 240 300 324 <210> 1087 <211> 324 163920-序列表.doc -481 · 201245225 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1087 gacatccasa tgacccagtc tccatcctcc atcacttgcc gggcaagttc caccattggc gggaaagccc ctaggctcct gatctatctt cgcttcagtg gcagtggatc tgggacagat gaagattttg ctacgtacta ctgtcatcag gggaccaaag tggaaatcaa acgg <210> 1088 <211> 324 <212> DNA <213>人工序列 <220> ctgtctgcat ctgtaggaga ccgagtcacc cgtcgtttaa attggtatca gcagaaacct gctacccgtt tgcaaagtgg ggtcccatca ttcactctca ccatcagcag tctgcaacct tatgagagtc cacctttgac gttcggccaa 60 120 180 240 300 324 <223>人工序列之描述：合成聚核苷酸 <40〇> 1088 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagttacc atcacttgcc gsgcaagttc ccagattggg cgtcgtttaa attggtacca gcagaaacca gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca-cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg
60 120 180 240 300 324 <210> 1089 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1089 gacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtga gcggattggg gggaaagccc ctaggctcct gatctatctt cgcttcagtg gcagtggatc tgggacagat gaasattttg ctacgtacta ctgtcatcag gggaccaaag tggaaatcaa acgg <210> 1090 <211> 324 <212> DNA <213>人工序列 <220> ctgtctgcat ctgtaggaga ccgagtcacc cgtcgtttaa attggtatca gcagaaacca gctacccgtt tgcaaagtgg ggtcccatca ttcactctca ccatcagcag tctgcaacct tatgagagtc cacctttgac gttcggccaa
120 180 240 300 324 <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc •482· 201245225 <400> 1090 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgaetcacc 60 atcacttgcc gggcaagtca gcagattggc cgccgtttaa attggtatca gcagaaacct 120 gggaaagccc ctaggctcct gatctatctt g:tacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag ntgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1091 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1091
gacatccaga tgacccagtc tccatcctcc c:gtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtca gccgattgcc ci^cgtttaa attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat tv.cactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tiitgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1092 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1092
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtgg gaacattggc citcgtttaa attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa gcgg 324 <210> 1093 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1093 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtcg gaacattgac cgtcgtttaa attggtacca gcagaaacca 120 163920-序列表.doc -483- 201245225 gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1094 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <40Q> 1094 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtca gagcattggg cgtcgtttaa attggtacca gcagaaacct 120 gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaastgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324
<210> 1095 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1095 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtca gaacattggg acgcgtttaa attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1096 <211> 324 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1096 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtga ggtcattggg cgtcgtttaa attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300 163920·序列表.doc • 484· 201245225 gggaccaaag tggaaatcaa acgg 324 <210> 1097 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1097 gacatccaga tgacccagtc tccatcctcc ctitctgcat ctgtaggaga ccgagtcacc atcacttgcc gggcaagtga ggcgattggc cgtcgtttaa attggtatca gcagaaacca gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg 60 120 180 240 300 324
<210> 1098 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷瞍 <400> 1098 gacatccaga tgacccagtc tccatcctcc ctj；tctgcat ctgtaggaga ccgagtcacc atcacttgcc gggcaagtac cagcattgcg cgtcgtttaa attggtatca gcagaaacct gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca cgcttcagtg gcagtggatc tgggacagat tti：actctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag ta:gagagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg 60 120 180 240 300 324
<210> 1099 <211> 324 <212> DNA <213>人工序列 <220> <223>•人工序列之描述：合成聚核苷酜 <400> 1099 gacatccaga tgacccagtc tccatcctcc ctitctgcat ctgtaggaga ccgagtcacc atcacttgcc gggcaagttt gaacattggg cglcgtttaa attggtacca gcagaaacca gggaaagccc ctaggctcct gatctatctt gc:acccgtt tgcaaagtgg ggtcccatca cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa gggaccaaag tggaaatcaa acgg .. 60 120 180 240 300
<210> 1100 <211> 324 <212> DNA 163920-序列表.doc •485 · 324 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1100 gacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtca gacgattgag gggaaagccc ctaggctcct gatctatctt cgcttcagtg gcagtggatc tgggacagat gaagattttg ctacgtacta ctgtcatcag gggaccaaag tggaaatcaa acgg ctgtctgcat ctgtaggaga ccgagtcacc cgtcgtttaa attggtacca gcagaaacca tcgtcgaagt tgcaaagtgg ggtcccatca ttcactctca ccatcagcas tctgcaacct tatgagagtc caccttt£ac gttcggccaa 60 120 180 240 300 324 <210> 1101 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1101 gaggtgcagc tgttggagtc tggggsaggc ttggttcagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatc caccattgct gggtatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg tgtctcagct attagtggta gtggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgagacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc
60 120 180 240 300 348 <210> 1102 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1102 gaggtgcagc cgttggagtc tgggggaggc tcctgtgcag cctccggatt cacctttgct ccagggaagg gtctagagcg gatctcagct gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggat tatagttttg actactgggg tcagggaacc ttggtacagc ctggggggtc cctgcgtctc gggtatgaga tgtggtgggt ccgccaggct attagcggta gtggtggtag cacatactac tcccgcgacg attccaagaa cacgctgtat accgcggtat attactgtgc gagagatcct ctggtcaccg tctcgagc
120 180 240 300 348 <210> 1103 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc -486- 201245225 <400> 1103 gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag ccaccggatc cacctttgct g{：gtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtccagagcg ggtctcagct altagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300 tacagttatg actactgggg tcagggaacc ctggtctccg tctcgagc 348 <210> 1104 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1104
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggact cacctttgct gggtatgaga tgtggtgggt ccgccaggca 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcagtat atcactgtgc gagagatcct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1105 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1105
gaggtgcagc tgttggagtc tgggggaggc ttigtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactctg tgaagggccg gttcaccatc tc:cgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat acogcggtat atcactgtgc gaaagaacct 300 tatagttatg actactgggg tcagggaacc ct：igtcaccg tctcgagc 348 <210> 1106 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醚 <400> 1106 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatc cacctttgct ggjjtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 163920-序列表.doc •487· 201245225 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tcccgaggat accgcggtat attactgtgt gaaagatcct 300 tatagttttg actactgggg tcagggaacc ctgstcaccg tctcgagc 348 <210> 1107 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1107 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatc caccattgcc gggtatgaga tgtggtgggt ccgccaggct 120 ccggggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300 tatagttttg actactgggg tcagggaacc ccggtcaccg tctcgagc 348
<210〉 1108 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1108 gaggtgcagc tgatggagtc tgggggagsc ttgstacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatc cacctttgct gggtatgaga tgtggtggta ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtagaag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1109 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1109 gaggtgcagc tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacgtactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcagtat attactgtgc gaaagaacct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 163920·序列表.doc -488 · 60201245225 <210> 1110 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷狡 <400> 1110 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatc caccattgct gggtatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcca tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 120 180 240 300 348
<210> 1111 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1111 gaggtgcagc tgttggagtc tgggggaggc tt^gtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgct gg.itatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat acogcggtat attactgtgc gagagaccct tatagttttg actactgggg tcagggaacc ctugtctccg tctcgagc 60 120 180 240 300 348
<210> 1112 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1112 gaggtgcagc tgttggagtc tgggggaggc ttugtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt caccattgct ggjitatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctccgct atiagtggta gtggtggtag cacatactac gcggactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct tatagttttg actactgggg tcagggaacc ctggtcaccg tttcgagc 60 120 180 240 300 348 <210> 1113 <211> 348 <212> DNA <213>人工序列 163920·序列表.doc 489- 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1113 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg tgtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc acccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tsccgaggat accgcggtat attactgtgc gaaagagcct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1114 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述··合成聚核苷酸 <400> 1114 gaggtgcagc tgttggastc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga. tgtggtggtt ccgccaggct 120 ccagggaagg gtctagagcg gstctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg ataccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accscggtat attactgtgc gaaagatcct 300 tatagttttg actactggcg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1115 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <40.0> 1115 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatc cacctttgct gggtatgagg tgtggtgggt ccgccaggct 120 ccagggaagg gtctggagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcgglat attactgtgc gagagatcct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1116 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1116 163920·序列表.doc •490· 201245225 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatc cacctttgct g；igtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg gatctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc toccgcgacg attccaagaa cacgctgtat 240 ctgaaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300 tatagttttg actactgggg tcagggaacc c:ggtcaccg tctcgagc 348 <210> 1117 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1117
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct giigtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct altagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1118 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1118
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggact cacctttgct gggtatgaga tgtggtgggt ccgccgggct 120 ccagggaagg gtctagagcg ggtcgcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1119 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1119 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggcc 120 ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtggtag cacatactac 180 163920·序列表.doc •491 · 201245225 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct tatagttttg actaccgggg tcagggaacc ctggtcaccg tctcgagc <21Q> 1120 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1120 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cccccggatt caccttagct gggtatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc <210> 1121 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 240 300 348 120 180 240 300
<400> 1121 gaggtgcagc tgttggagtc tgggggaggc tcctgtgcag cctccggact cacctttgct ccagggaagg gtctagagcg ggtctcagct gcagactccg tgaagggccg gttcaccacc ctgcaaatga acagcctgcg tgccgaggat tatagttttg actactgggg tcggggaacc <210> 1122 <211> 348 <212> DNA <213>人工序列 <220> ttggtacagc ctggggggtc cctgcgtctc gggtatgaga tgtggtgggt ccgtcgggct attagtggta gtggtggtag cacatactac tcccgcgacg attccaagaa cacgctgtat accgcggtat attactgtgc gagagatcct ctggtcaccg tctcgagc 60 120 180 240 300 348
<223>人工序列之描述：合成聚核苷酸 <400> 1122 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ccggggggtc cctgcgtctc tcctgtgccg cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct ccagggaags gtctagagcg ggtctcagct attagtggta scggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgc^stat attactgtgc gaaagaacct tatagttatg actactgggg tcatggaacc ctgsttactg tctcgagc 60 120 180 240 300 348 • 492· 163920·序列表.doc 60201245225 <210> 1123 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1123 gaggtgcagc cgttggagtc tgggggaggc t'：ggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgct gjjgtatgaga tgtggtgggt ccgccaggct ccag£gaagg gtctagagcg ggtctcagct ai:tagtggta gtggtggtaa cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat acxggggtat attactgtgc gagagatcct tatagttttg actactgggg tcagggtacc ctggtcaccg tctcgagc 120 180 240 300 348
<210> 1124 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1124 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct tatagttttg actcctgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348
<210> 1125 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1125 gaggcgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt aaccttcgct gggtatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg cgtctcagct attagtggta gtggcggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 60 120 180 240 300 348 <210> 1126 <211> 348 <212> DNA <213>人工序列 163920·序列表.doc 493- 201245225 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1126 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatc cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttctccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300 tatagttttg accactgggg tcagggaacc ct£gtcaccg tctc£a$c 348 <210〉 1127· <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1127 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctcgggatc cacctttgct gggtatgaga tgtggtgggt ccgcagggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta etggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc sagagatcct 300 tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1128 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1128 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300 tatagttttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1129 <2U> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1129 ,Λ gaggtgcagc tgttggagtc tgggggaggc ttggtagagc ctggggggtc cctgcgtctc 60 163920-序列表.doc •494- 201245225 tcctgtgcag cctccggatt cacctttgct gjjgtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcs ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat aocgcggtat attactgtgc gaaagaacct 300 tatagttttg accaccgggg tcagggaacc oggtcaccg tctcgagc 348 <210> 1130 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1130
gaggtgcagc tgttggagtc tgggggaggc tiggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggata cacctttgct g{：gtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300 tatagttttg accaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1131 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1131
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaagaacct 300 tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1132 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1132 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 163920·序列表.doc -495- 201245225 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300 tatagttttg acaactiggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1133 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1133 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactctg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300 tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1134 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1134 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 cccgggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300 tatagttttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 1135 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1135 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactctg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaagaacct 300 tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 163920-序列表.doc •496· 201245225 <210> 1136 <211> 348 <212> DNA <2]3>人工序列 <220> <223>人工序列之描述：合成聚核苷骏 <400> 1136 gaggtgcagc tgttggagtc tgggggaggc tlggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gjgtatgaga tgtggtggtt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300 tatagttttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1137 <211> 348 <212> DNA <213>人工序列 <223>人工序列之描述：合成聚核苷酸 <400> 1137 gaggtgcagc tgttggagtc tgggggaggc tlggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggcc 120 ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300 tatagttttg actaccgggg tcagggaacc ct^gtcaccg tctcgagc 348
<210> 1138 <211> 348 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1138 gaggtgcagc tgttggagtc tgggggaggc tt；;gtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggcc ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct tatagttttg actactgggg tcagggaacc ct；;gtcaccg tctcgagc 60 120 180 240 300 <210> 1139 <211> 360 <212> DNA <213>人工序列 <220> 163920-序列表.doc 497· 348 201245225 <223>人工序列之描述：合成聚核苷酸 <400> 1139 gaggtgcagc tgttggagtc tggggggggc tt£gtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttccg actgctgaga tgctgtgggt ccgcaaggct ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc saaagagccg gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc <210> 1140 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1140 gaggtgcagc tgttggtgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttccg actgctgaga tgttgtgggt ccgccaggct ccagggaagg gtccagagtg ggtctcatca atttcggcta gtggtggttc tacatactat gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc <210> 1141 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1141 gaggtgcagc tgttggagtc tgggggaggc tcgtgtgcag cctccggatt cacctttccg ccagggatgg gtctagagtg ggtctcatct gcagactccg tgaagggccg gttcaccatc ctgcaaatga acagcctgcg tgccgaggac gtgagttatg tggcgacgtt tgactactgg ttggtacagc ctggggggtc cctgcgtctc actgccgaga tggtgtgggt ccgcaaggct atttcggcta gtggtggtta tacatactac tcccgcgaca attccaagaa catgctgtat accgcggtat attactgtgc gaaagagccg ggtcagggag ccctggtcac cgtcacgagc <210> 1142 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1142 gaggtgcagc tgttggtgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc -498- 163920·序列表.doc
201245225 tcctgtgcag cctccggatt cacctttccg aotgctgaga tigtgtgggt ccgccaggct ccagggaagg gtctagagts ggtctcatct atttcggcta gtggtggttc tacatactac gcagactccg tgaagggccg gttctccatc toccgcgacg attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac aocgcggtat attactgtgc gaaagagccg gtgagttatg tggcgacgtt tgactactgg gutcatggag ccctggtcac cgtctcgagc <210> 1143 <211> 360 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1143 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacatttccg actgctgaga tgttgtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg agccgaggac accgcggtat attactgtgc gaaagagccg gtgagttatg tggcaacgtt tgactactgg g£tcagggaa ccctggtcac cgtctcgagc <210> 1144 <21】> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 120 180 240 300 360 60 120 180 240 300 360
60 120 180 240 300 360 <400> 1144 gaggcgcagc tgttggagtc tggg£gtggc tcctgtgcag cctccggatt cacctttccg ccagggaagg gtctagagtg gatctcatct gcagactccg tgaagggccg gttcaccatc ctgcaattga acagcctgcg tgcciaggac gtgagttatg tggcgacgtt tgactactgg ttggtacagc ctggggggtc cctgcgtctc actgctgaga tggtgtgggt ccgccaggct atttcggcta gtggtggttc tacatactac tcccgcgaca attccaagaa cacgctgtat accgcggtat attactgtgc gaaagagccg ggtcggggaa ccctggtcac cgtctcgagc <210> 1145 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷蚝 <400> 1145 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg tgttggagtc cctccggatt gtctagagtg tgaagggccg tgggggaggc cacatttccg ggtctcatct gttcaccatc tt.igtacagc actgctgaga atttcggcta tcccgcgaca ctggggggtc tgttgtgggt gtggtggttc attccaagag cctgcgtctc ccgccaggct tacatactac cacgctgtat 60 120 180 240 -499· 163920-序列表.doc 201245225 300 360 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg gtgagttatg tggcgacgtt tgactactgg ggtccaggag ccctggtcac cgtctcgagc <210> 1146 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1146 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gtgagttatg tgttggagtc cctccggatt gtctagagtg tgaagggcc£ acagcctgcg tggcgacgtt cgggggaggc cacctttccg ggtctcatct gttcaccatc tgccgaggac tgactactgg ttggtacagc actgctgaga atttcggcta tcccgcgaca accgcggtat ggtcagggaa ctggggggtc tgctgtgggt gtggtggttc attccaagaa attactgtgc ccctggtcac cctgcgtctc ccgcaaggct tacatactac cacgctgttt caaagagccg cgtctcgagc 60 120 180 240 300 360 <210> 1147 <211> 360 <212> DNA <213>人工序列
<220> <223>人工序列之描述：合成聚核苷酸 <400> 1147 gaggtgcagc tcctgtgcag ccagggaagg gcagactccg ctgcaaatga gtgagttatg tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc cctccggatt cacatttccg actgctgaga tgttgtgggt ccgccaggct gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg tggcgacgtt tgactactgg ggtccaggag ccctggtcac cgtctcgagc 60 120 180 240 300 360 <210> 1148 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1148 gagstgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttccg actgctgaga tgctgtgggt ccgccaggct ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ttgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg gtgtattatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360 <210> 1149 163920-序列表.doc •500· 201245225 <211> 360 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1149 gaggtgcagc tgttggagtc cgggggaggc t '.ggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttccg actgctgaga tgctgtgggt ccgcaaggct ccagggaagg gtctagagtg ggtctcatct autcggcta gtggtggttc tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaagagccg gtgagttatg tggcgacgtt tgactactgg gi；tcagggaa ccctggtcac cgtctcgagc 60 120 180 240 300 360
<210> 1150 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1150 aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt actctgttaa cttggtacca gcataaacca gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324
<210> 1151 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1151 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca cggaaagccc ctaaactcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcatcct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggtcaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324 <210> 1152 <211> 324 <212> DNA <213>人工序列 <220> <2M>人工序列之描述：合成聚核苷酸 163920·序列表.doc .501 · 201245225 <400> 1152 gacatccaga tgacccagtc tccgtcctcc ctgactgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct ggtcacttat ggttccitgt tscaaagtgg ggtcccatca 180 cgtttcagtg gcagtgsatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt sscctcctac gttcggccaa 300 gggaccaagg tggaaaacat acgg 324 <210> 1153 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1153 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattgct actctgttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300 ggsaccaagg tggaaatcaa acgg 324
<210> 1154 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1154 gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattgct actctgttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324
<210> 1155 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1155 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120 163920·序列表.doc -502· 201245225 gggaaagcca ctaagctcct gatcacttat gi；ttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagactttg ctacgtacta ctgtggtcag ggggtgctgt ggcccccgac gttcggccag 300 gggaccaagg tggaaatcaa acgt 324 <210> 1156 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述•·合成聚核苷酸 <400> 1156
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt tctctgttat cttggtacca gcataaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1157 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1157
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttoactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1158 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醚 <400> 1158 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tt:actctca ccatcagcag tctgcaacct 240 gaagattttg caacgtacta ctgtggtcag gg^gtgctgt ggcctgcgac gttcggccaa 300 163920·序列表.doc •503 - 201245225 gggaccaagg tggaaatcaa acgg 324 <210> 1159 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1159 gacatccaga tgactcagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cctggtacca gcataaacca 120 gggaaagccc ctaagctcct gatcacctat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gca^t£gatc tgggacagaa ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggagtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1160 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400〉 1160 gacatccaga tgacccagtc tccatcctcc ctgactgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagaa ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1161 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1161 aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1162 <211> 324 163920·序列表.doc 504- 201245225 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1162 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcaattgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca gggaaagccc ctaagctcct gatcacttat g£ttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324
<210> 1163 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1163 gacatccagt tgacccagtc accatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca gggaaagcca ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324
<210> 1164 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1164 gacatccaga tgacacagtc tccatcctcc ctgtatgcat ctgtaggaga ccgtgtcacc atcacttgcc gggtaagtca ttttattggt actctgttat cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat tt:actctca gcatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggigtgctgt ggcccccgac gttcggacaa gggaccaagg tggaaatcaa acag 60 120 180 240 300 324 <210> 1165 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920-序列表.doc - 505 - 201245225 <40Q> 1165 gacattcaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120 aggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1166 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1166 gacatccaga ttatccagtc tccatcctcc ctttctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300 gggaccaagg tg^aaatcaa acgg 324
<210> 1167 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1167 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120 gggaaagccc ctaagctcct gatcacttat sgttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324
<210> 1168 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1168 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120 163920·序列表.doc -506- 201245225 gggaaagccc caaagctcct gatcacttat gr.ttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag g£ggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tagaaaacaa acgg 324 <210> 1169 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1169
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcttaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaacgtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 £ggaccaagg tggaaatcaa acgg 324 <210> 1170 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷耻 <400> 1170
gacatccaga tgacccaggc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcagagtgg ggtcccatca ISO cgtttcagtg gtagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg ttgaaaacaa acgg 324 <210> 1171 <211> 324 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1171 gacatccaga tgacccagtc tccatcctcc ct；;tctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt tctctgttat cttggtacca gcagaaacca 120 gggaaagccc caaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcgctctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggijgtgctgt ggcctgcgac gttcggccaa 300 163920·序列表.doc -507- 201245225 gggaccaagg tggaaatcaa acgg 324 <210> 1172 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1172 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag Sg£gtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1173 <211> 324 <212> DNA <213》人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1173 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1174 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1174
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctggtat cttggtacca gcagaaaccg 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gtacggccaa 300 gggaccaagg tggaaatcaa ac£g 324 <210> 1175 <211> 324 <212> DNA 163920•序列表.doc 508- 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1175 gacatccaga atcacttgcc gggaaagccc cgtttcagtg gaagattttg gggaccaagg tgacccagtc tccatcctct gggcaagtca ttttattggt ctaagctcct gatcacttat gcagtggatc tgggacagat ctacgtacta ctgtggtcag tggaaaacaa acgg cigtctgcat ctgtaggaga ccgtgtcacc aotctggtat cttggtacca gcagaaacca gi；ttccttgt tgcaaagtgg ggtcccatca t:cactctca ccatcagcag tctgcaacct gi；ggtgctgt ggcctgcgac tttcggccaa <210> 1176 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷傻 <400> 1176 gacatcaaga tgacccagtc tccatcctcc clgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcgagtca ttttattggt actctggtat cttggtacca gcagaaacca gggaaagccc caaagctcct gatcacttat ggttccatgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa gggaccaagg tggaaatcaa acgg <210> 1177 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1177 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc aggcaagtca ttttattggt actctggtat cctggtacca gcagaaacca gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcccgcgac gttcggccaa gggaccaagg tggaaatcaa acgg <210> 1178 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 163920·序列表.doc -509- 60 120 180 240 300 324 60 120 180 240 300 324 60 120 180 240 300 324 201245225 <400> 1178 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120 gggaaagccc-ctaagctcct gatcacttat ggttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1179 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1179
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1180 <211> 324 <212> DNA <213>人工序列 <220〉 <223>人工序列之描述：合成聚核苷酸 <400> 1180
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaaccg 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatt tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag gaggtgctgt ggcctgcgac gttcggccaa 300 gggactaagg tggaaatcaa acgg 324 <210> 1181 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1181 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtctcc 60 atcacttgcc gagcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
Sggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 •510- 163920·序列表.doc 240201245225 cgtttcagtg gcagtggatt tgggacagat ttcactctca ccatcagcag tctgcaacct gaagatcttg ctacgtacta ctgtggtcag gaggtgctgt ggcctgcgac gttcggccaa gggaccaagg tggaaatcaa acgg 300 324 <210> 1182 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1182 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc aggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcacttat gsttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatt tgggacagat ttcactctca ccatcagcag tctgcaaccc gaagattttg ctacgtacta ctgtggtcag gaggtgctgt ggcctgcgac gttcggccaa ggiaccaagg tggaaatcaa acgg 60 120 180 240 300 324 <210> 1183 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1183 gacatccaga tgacccagtc tccatcctcc ctgtctgcat cagtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacct £ggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatt tgggacagaa tt:actctca ccatcggcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggsgtgctgt ggcctgcgac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324
<210> 1184 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酞 <400> 1184 gacatccaga tgacccagtc accatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca gggaaagcca ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggj；gtgctgt ggcctccgac gttcggccaa gggaccaagg tggaaatcaa acgg 60 120 180 240 300 324 163920·序列表.doc •511 - 201245225 <210> 1185 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1185 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca cttcattgcc agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tmacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1186 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1186 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca tttcattgcc cagctgttat cttggtacca ggtgaaacca 120 ggsaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1187 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1187 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc £ggcaagtca tttcattgcc cagctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctstggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcag acgg 324 <210> 1188 <211> 324 <212> DNA <213>人工序列 163920·序列表.doc 512· 201245225 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1188 gacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtca ttacattgcc gggaaagccc ctaagctcct gatcacttat cgtttcagtg gcagtggatc tgggacagat gaagattttg ctacgtacta ctgtggtcag gggacaacgg tggaaatcaa acgg ctgtctgcat ctgtaggaga ccgtgtcacc tocctgttat cttggtacca ggtgaaacca gi^ttccttgt tgcagagtgg ggccccatca tlcactctca ccatcagcag tctgcaacct 郎ggtgctgt ggcctgcgac gttcggccaa 60 120 180 240 300 324
<210> 1189 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1189 gacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtca ttttattggt gggaaagccc ctaagctcct gatcacttgg cgtttcagtg gcagtggatc tgggacagat gaagattttg ctacgtacta ctgtggtcag gggacaacgg tggaaatcaa acgg ci.gtctgcat ctgtaggaga ccgtgtcacc ai；tctgttat cttggtacca ggtgaaacca gcctcctact tgcaaagtgg ggtcccatca tlcactctca ccatcagcag tctgcaacct gi：ggtgctgt ggcctgcgac gttcggccaa <210> 1190 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1190 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca gggaaagccc ctaagctcct gatcacttgg acgtcctact tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa gggacaacgg tggaaatcaa acgg <210> 1191 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1191 163920·序列表.doc •513- 60 120 180 240 300 324 60 120 180 240 300 324 201245225 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtstcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcactt£g tcgtcctact tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1192 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1192 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttgg gggtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324
<210> 1193 <211> 324 <212> DNA <213>人工序列 <22Q> <223>人工序列之描述：合成聚核苷酸 <400> 1193 gacatccaga tsacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gsgcaastca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttgg gcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324
<210> 1194 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1194 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttgg agctcctggt tgcaaagtgg ggtcccatca 180 163920-序列表.doc -514· 201245225 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa gggacaacgg tggaaatcaa acgg 240 300 324 <210> 1195 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1195 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttggattgcc c；igctgttat cttggtacca ggtgaaacca gggaaagccc ctaagctcct gatcacttat giutccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag gj^ggtgctgt ggcctgcgac gttcggccaa gggacaacgg tggaaatcaa acgg 60 120 180 240 300 324 <210> 1196 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1196 gacatccaga tgacccagtc tccatcctcc ci:gtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt tcgctcttac gctggtacca ggtgaaacca gggaaagccc ctaagctcct gatcacttat g{：ttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag g£：ggtgctgt ggcctgcgac gttcggccaa gggacaacgg tggaaatcaa acgg 60 120 180 240 300 324
<210> 1197 <211> 324 <2i2> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1197 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca tcggattgcc cagctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag gsggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 163920·序列表.doc -515- 201245225 <210> 1198 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1198 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttacattgcc tccctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1199 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之猫述：合成聚核苷酸
<400> 1199 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatccggttc ggctccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1200 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1200 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttac aagtcctact tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1201 <211> 324 <212> DNA <213>人工序列 163920·序列表.doc 516· 60201245225 <220> <2M>人工序列之描述：會成聚核苷睃 <400> 1201 gacatccaga tgacccagtc tccatcctcc cigtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttttattggt aiitctgttat cttggtacca ggtgaaacca gggaaagccc ctaagctcct gatcacttgg gj：ctcctact tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat. ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag gj：ggtgctgt ggcctgcgac gttcggccaa gggacaacgg tggaaatcaa acgg 120 180 240 300 324 <210> 1202 <211> 324 <212> DNA <213>人工序列 <220> <2M>人工序列之描述：合成聚核苷睃
<400〉 1202 gacatccaga atcacttgcc gggaaagccc cgtttcagtg gaagattctg gggacaacgg tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc gggcaagtca ttttatttgg gggcccttat cttggtacca ggtgaaacca ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa tggaaatcaa acgg 60 120 180 240 300 324 <210> 1203 <211> 324 <21.2> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1203 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca ttggattgcc accctgttat cttggtacca ggtgaaacca gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa gggacaacgg tggaaatcaa acgg 60 120 180 240 300 324 <210> 1204 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醚 <400> 1204 gacatccaga tgacccagtc tccatcctcc ct.gtctgcat ctgtaggaga ccgtgtcacc 60 163920-序列表.doc -517- 201245225 atcacttgcc gggcaagtca ttttatttgg gggcccttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg £gtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324 <210> 1205 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1205 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agcctcttaa actggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324
<210> 1206 <211> 324 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1206 ggcatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120 gggaaagccc ctaagctcct gatcacttac gggtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacasat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300 gggacaacgg tggaaatcaa acgg 324
<210> 1207 <211> 5 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <400> 1207 Gly Gly Gly Gly Ser 1 5
<210> 1208 <211> 15 <212> PRT 163920-序列表.doc 518· 201245225 <213>人工序列 <220> <223>人工序列之描述：合成肽 <400> 1208
Gly Gly Gly Gly Ser Gly Gly Gly Glv Ser Gly Gly Gly Gly Ser 15 10 15 <210> 1209 <211> 25 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <400> 1209
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 15 10 15
Gly Gly Gly Ser Gly Gly Gly Gly Sei 20 25 <210> 1210 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1210
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie Thr Cys Arg Ala 130 135 140 -519- 163920-序列表.doc 201245225
Ser Arg Pro lie Gly Thr Thr Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Trp Asn Ser Arg Leu Gin Ser Gly 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190
Thr lie Ser Ser Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225 <210> 1211 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1211
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie Thr Cys Arg Ala 130 135 140
Ser Arg Pro lie Gly Thr Met Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Ala Phe Ser Arg Leu Gin Ser Gly •520·
163920-序列表.doc 201245225 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 lS：i 190
Thr lie Ser Ser Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Ala Gly Thr His His Thr Thr Ph<; Gly Gin Gly Thr Lys Val Glu 210 215 220
He Lys Arg 225 <210> 1212 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽
<400> 1212
Glu Val Gin Leu Leu Glu Ser Gly Gb Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie Thr Cys Arg Ala 130 135 140
Ser Arg Pro lie Gly Thr Thr Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Trp Asn Ser Arg Leu Gin Ser Gly 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190 •521 · 163920-序列表.doc 201245225
Thr lie Ser Ser Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225 <210> 1213 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1213
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr He Thr Cys Arg Ala 130 135 140
Ser Arg Pro lie Gly Thr Met Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Ala Phe Ser Arg Leu Gin Ser Gly 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190
Thr lie Ser Ser Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205 - 522-
163920·序列表.doc 201245225
Gin Ala Gly Thr His His Thr Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225 <210> 1214 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1214
Asp lie Gin Met Thr Gin Scr Pro Se:: Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Thr 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Trp Asn Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Alg. Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Gli, lie Lys Arg Thr Val Ala Ala 100 101 110
Pro Ser Glu Val Gin Leu Leu Glu Sei Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr 210 215 220 - 523 - 163920·序列表.doc 201245225
Leu Val Thr Val Ser Ser 225 230 <210〉 1215 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1215
Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His His Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1216 524-
163920·序列表.doc 201245225 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1216
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Als. Ser Arg Pro lie Gly Thr Thr 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gl> Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Trp Asn Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp • 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1217 <211> 230 <212> PRT <213>人工序列 <220> - 525 - 163920-序列表.doc 201245225 <223>人工序列之描述：合成多肽 <400> 1217
Asp lie G】n Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Va】G】y 15 10 15
Asp Arg Val Thr He Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu He 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His His Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn TTir 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1218 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1218
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly •526-
163920·序列表.doc 201245225 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ah. Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Gli. lie Lys Arg Thr Val Ala Ala 100 lOf 110 ❿
Pro Ser Glu Val Gin Leu Leu Glu Sei Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1219 <211> 230 <212> PRT <213>人工序列 <220> <2M>人工序列之描述：合成多肽 <400> 1219
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30 • 527- 163920·序列表 _doc 201245225
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1220 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1220
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45 -528-
163920-序列表.doc 201245225
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr L<：u Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Val His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 18.5 190
Leu Tyr Leu Gin Met Asn Ser Leu Ari» Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gin Glu Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1221 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1221
Asp lie Gin Met Thr Gin Ser Pro Sev Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ah. Ser Arg Pro He Gly Thr Thr 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Trp Asn Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 -529- 163920-序列表.doc 201245225
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu 130 135 140
Glu Glu Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Trp Val Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Tlu 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1222 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1222
Glu Val Gla Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys • 530-
163920-序列表.doc 201245225 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 10:5 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arj： Val Thr lie Thr Cys Arg Ala 130 135 140
Ser Arg Pro lie Gly Thr Thr Leu Sty Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Trii Asn Ser Arg Leu Gin Ser Gly 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 18f 190
Thr lie Ser Ser Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225 <210> 1223 <211> 230 <212> PRT <213>人工序列 <220> <2M>人工序列之描述：合成多肽 <400> 1223
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Gin Trp He Gly Ser Gin 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Met Trp Arg Ser Ser Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Gly Leu Arg His Pro Lys 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu He Lys Arg Thr Val Ala Ala 100 105 110 -531 - 163920-序列表.doc 201245225
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe TTir Phe Glu 130 135 140
Glu Glu Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Trp Val Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1224 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1224
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125 -532-
163920·序列表.doc 201245225
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr He Thr Cys Arg Ala 130 135 140
Ser Gin Trp lie Gly Ser Gin Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Met Trp Arg Ser Ser Leu Gin Ser Gly 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190
Thr lie Ser Ser Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Gly Leu Arg His Pro Lys Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225
<210> 1225 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1225
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie Thr Cys Arg Ala 130 135 140 - 533 - 163920-序列表.doc 201245225
Ser Arg Pro lie Gly Thr Thr Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Trp Asn Ser Arg Leu Gin Ser Gly 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190
Thr lie Ser Ser Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225 <210> 1226 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1226
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Asp lie Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie Thr Cys Arg Ala 130 135 140
Ser Arg Pro lie Gly Thr Met Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Ala Phe Ser Arg Leu Gin Ser Gly •534·
163920·序列表.doc 201245225 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190
Thr lie Ser Asn Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225 <210> 1227 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 ❿
<400> 1227
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Thr 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Trp Asn Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Ser Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu 130 135 140
Glu Glu Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Trp Val Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190 - 535 - 163920-序列表.doc 201245225
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Cly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1228 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1228
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly TTir Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu 130 135 140
Glu Glu Glu Met lie Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Trp Val Ser Ala lie Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205 -536-
163920-序列表.doc 201245225
Tyr Cys Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Val Ser Ser 225 230 <210> 1229 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1229
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Fro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Glu 100 105 110
Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly Ser 115 120 125
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr Glu 130 135 140
Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val Ser 145 150 155 160
Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val Lys 165 170 175
Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 180 185 190
Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 195 200 205
Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val Thr 210 215 220 - 537- 163920·序列表.doc 201245225
Val Ser Ser 225 <210> 1230 <211> 231 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1230
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Ala Ser Thr Ser 100 105 110
Gly Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin 115 120 125
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 130 135 140
Arg Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu 145 150 155 160
Glu Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala 165 170 175
Asp Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn 180 185 190
Thr Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 195 200 205
Tyr Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly 210 215 220
Thr Leu Val Thr Val Ser Ser 225 230 <210> 1231 163920-序列表.doc - 538- 201245225 <211> 229 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1231
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe wSer Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Asn Lea Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Gly Gly Gly Gly 100 105 110
Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly 115 120 125
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp 130 135 140
Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg 145 150 155 160
Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser 165 170 175
Val Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu 180 185 190
Tyr Leu Gin Met Asn Scr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 195 200 205
Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu 210 215 220
Val Thr Val Ser Ser 225 <210> 1232 <211> 239 <212> PRT <213>人工序列 <220> 539 · 163920-序列表.doc 201245225 <223>人工序列之描述：合成多肽 <400> 1232
Asp He Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Lea Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Gly Gly Gly Gly 100 105 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gin Leu Leu 115 120 125
Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly Ser Leu Arg Leu Ser 130 135 140
Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr Glu Met Trp Trp Val 145 150 155 160
Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val Ser Ala lie Asn Pro 165 170 175
Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 180 185 190 lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gin Met Asn Ser 195 200 205
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Pro Phe 210 215 220
Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 225 230 235 <210> 1233 <211> 249 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1233
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly •540·
163920-序列表.doc 201245225 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Gly Gly Gly Gly 100 105 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125
Gly Gly Gly Gly Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu 130 135 140
Val Gin Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 145 150 155 160
Thr Phe Arg Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys 165 170 175
Gly Leu Glu Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr 180 185 190
Tyr Ala Asp Scr Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser 195 200 205
Lys Asn Thr Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr 210 215 , 220
Ala Val Tyr Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly 225 230 235 240
Gin Gly Thr Leu Val Thr Val Ser Ser 245 <210> 1234 <211> 227 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1234
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15 -541 - 163920-序列表.doc 201245225
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Thr Val Ala Asp He Gin Met Thr Gin Ser Pro Ser 115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie Thr Cys Arg Ala 130 135 140
Ser Arg Pro lie Gly Thr Met Leu Ser Trp Tyr Gin Gin Lys Pro Gly 145 150 155 160
Lys Ala Pro Lys Leu Leu lie Leu Ala Phe Ser Arg Leu Gin Ser Gly 165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190
Thr lie Ser Asn Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala 195 200 205
Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly Thr Lys Val Glu 210 215 220 lie Lys Arg 225 <210> 1235 <211> 231 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1235
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 -542-
163920-序列表.doc 201245225
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Giy Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Ser Gly Pro Ser Asp lie Gin Met Thr 115 120 125
Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie 130 135 140
Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met Leu Ser Trp Tyr Gin 145 150 155 160
Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie Leu Ala Phe Ser Arg 165 170 175
Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 180 185 190
Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro Glu Asp Phe Ala Thr 195 200 205
Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly 210 215 220
Thr Lys Val Glu He Lys Arg 225 230 <210> 1236 <211> 229 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1236
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45 - 543 163920-序列表.doc 201245225
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Gly Gly Gly Gly Ser Asp He Gin Met Thr Gin Ser 115 120 125
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr lie Thr Cys 130 135 140
Arg Ala Ser Arg Pro lie Gly Thr Met Leu Ser Trp Tyr Gin Gin Lys 145 150 155 160
Pro Gly Lys Ala Pro Lys Leu Leu lie Leu Ala Phe Ser Arg Leu Gin 165 170 175
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 180 185 190
Thr Leu Thr lie Ser Asn Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr 195 200 205
Cys Ala Gin Ala Gly Thr His Pro Thr Thr Phe Gly Gin Gly Thr Lys 210 215 220
Val Glu lie Lys Arg 225 <210> 1237 <211> 239 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1237
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala He Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr • 544·
163920-序列表.doc 201245225 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125
Gly Gly Ser Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala 130 135 140
Ser Val Gly Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie 145 150 155 160
Gly Thr Met Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys 165 170 175
Leu Leu lie Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg 180 185 190
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn 195 200 205
Leu Gin Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr 210 215 220
His Pro Thr Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg 225 230 235 <210> 1238 <211> 249 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1238
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 - 545 - 163920-序列表.doc 201245225
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Gin 130 135 140
Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 145 150 155 160
Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met Leu Ser Trp 165 170 175
Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie Leu Ala Phe 180 185 190
Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 195 200 205
Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro Glu Asp Phe 210 215 220
Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr Thr Phe Gly 225 230 235 240
Gin Gly Thr Lys Val Glu lie Lys Arg 245 <210> 1239 <211> 230 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1239
Asp lie Gin Met Thr Gin Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 15 10 15
Asp Arg Val Thr lie Thr Cys Arg Ala Ser Arg Pro lie Gly Thr Met 20 25 30
Leu Ser Trp Tyr Gin Gin Lys Pro Gly Lys Ala Pro Lys Leu Leu lie 35 40 45
Leu Ala Phe Ser Arg Leu Gin Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Leu Gin Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gin Ala Gly Thr His Pro Thr 85 90 95 •546-
163920-序列表.doc 201245225
Thr Phe Gly Gin Gly Thr Lys Val Glu lie Lys Arg Thr Val Ala Ala 100 105 110
Pro Ser Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro 115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg 130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu 145 150 155 160
Arg Val Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp 165 170 175
Ser Val Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr 180 185 190
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gin Gly Thr 210 215 220
Leu Val Thr Va丨 Ser Ser 225 230 <210> 1240 <211> 681 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1240 60 120 180 240 300 360 420 480 540 600 660 681 gaggtgcagc tgttggagtc tgggggaggc ttigtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcg£ gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac gcagactccg tgaagggccg gttcaccatc tcocgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgeegaggae accgcggtat attactgtgc gaaacttccg ttttactttc aggagtgggg tcagggaacc ct：>gtcaccg tctcgagcgc tagcaccgac atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc aettgeeggg caagtcgtcc gattgggacg ac.ittaagtt ggtaccagca gaaaccaggg aaagccccta agctcctgat cctttggaat tcocgtttgc aaagtggggt cccat.cacgt ttcagtggca gtggatctgg gacagatttc actctcacca teageagtet gcaacctgaa gattttgcta cgtactactg tgcgcaggct gg：sacgcatc etaegaegtt cggccaaggg accaaggtgg aaatcaaacg g
<210> 1241 <211> 681 <212> DNA -547- 163920-序列表.doc 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1241 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcs tacatactac 180 gcagactccg tgaagggccg sttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360 atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420 acttgccggg caagtcgtcc gattgggacg atgttaagtt ggtaccagca gaaaccaggg 480 aaagccccta agctcctgat ccttgctttt tcccgtttgc aaagtggggt cccatcacgt 540 ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgcgcaggct gggacgcatc atacgac^tt cggccaaggg 660 accaaggtgg aaatcaaacg g 681 <210> 1242 <211> 681 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1242
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgt££tgg£t ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360 atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420 acttgccggg caagtcgtcc gattgggacg acgttaagtt ggtaccagca gaaaccaggg 480 aaagccccta agctcctgat cctttggaat tcccgtttgc aaagtggggt cccatcacgt 540 ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600 gattttgcta cgtactactg tgcgcaggct gggacgcatc ctacgacgtt cggccaaggg 660 accaaggtgg aaatcaaacg g 681 <210> 1243 <211> 681 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 • 548- 163920-序列表.doc 201245225 <400> 1243 gaggtgcagc tgttggagtc tggggaaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360 atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420 acttgccggg caagtcgtcc gattgggacg atgttaagtt ggtaccagca gaaaccaggg 480 aaagccccta agctcctgat ccttgctttt tcccgtttgc aaagtggggt cccatcacgt 540 ttcagtggca.gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600 gattttgcta cgtactactg tgcgcaggct gggacgcatc atacgacgtt cggccaaggg 660 accaaggtgg aaatcaaacg g 681
<210> 1244 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷醚
<400> 1244 gacatccaga tgacccagtc tccatcctcc ct；;tctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtcg tccgattggg ac；>acgttaa gttggtacca ecagaaacca gggaaagccc ctaagctcct gatcctttgg aattcccgtt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttoactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgcgcag gc:gggacgc atcctacgac gttcggccaa g£gaccaagg tggaaatcaa acgtacggtg gc:gcaccat ctgaggtgca gctgttggag tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag cgggtctcag ctattaatcc gcagggtacg cgnacatact acgcagactc cgtgaagggc cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg cgtgccgagg acaccgcggt atattactgt gcnaaacttc cgttttactt tcaggagtgg ggtcagggaa ccctggtcac cgtctccagc 60 120 180 240 300 360 420 480 540 600 660 690 <210> 1245 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷断 <400> 1245 gacatccaga tgacccagtc tccatcctcc cti；tctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtcg tccgattggg acg;atgttaa gttggtacca gcagaaacca 60 163920.序列表.d〇c - 549- 120 201245225 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcatacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360 tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420 ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480 cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660 ggtcagggaa ccctggtcac cgtctccagc 690 <210> 1246 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1246
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgacgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcctttgg aattcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360 tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420 ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480 cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcacgagtgg 660 ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1247 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1247 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 163920·序列表.doc -550- 201245225 gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcatacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360 tctgggggag gcttggtaca gcctgggggg ti:cctgcgtc tctcctgtgc agcctccgga 420 ttcacctttc gggattatga gatgtggtgg guccgccagg ctccagggaa gggtctagag 480 cgggtctcag ctattaatcc gcagggtacg cf；tacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcacgagtgg 660 ggtcagggaaccctggtcac cgtctccagc 690 <210> 1248 <211> 690 <212> Wk <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1248
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360 tccgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420 ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480 cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660 ggtcagggaa ccctggtcac cgtctccagc 690 <210> 1249 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1249 gacatccaga tgacccagtc tccatcctcc ctitctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg aciatgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tt:actctca ccatcagcag tctgcaacct 240 gaagatgttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360 tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420 -551 · 163920·序列表.doc 201245225 ttcacctttc gggattatga gatgtggtgg gtccgccagg ctcca^ggaa ££2tctagag 480 cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660 ggtcagggaa ccctggtcac cgtctccagc 690 <210> 1250 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <4〇〇> 1250 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcastg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag gctggggtgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360 tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420 ttcacctttc gggattatga gatgtggtgs gtccgccagg ctccagggaa gggtctagag 480 cgggtctcag ctattaatcc gcagggtacs cgtacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660 ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1251 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1251
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgacgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcctttgg aattcccgtt t£caaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360 tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga 420 ttcacctttg ag^aggagga gatgatttgg gtccgccags ctccagggaa gggtctagag 4S0 tgggtctcag ctattagtag gaacggttac agcacatact acgcagactc cgtgaagggc 540 163920·序列表.doc -552- 201245225 cggttcacca tctcccgcga caattccaag aac：acgctgt atctgcaaat gaacagcctg cgtgccgagg ataccgcggt atattactgt ggs：aaagagc cgtttcgtta tgactactgg ggtcagggaa ccctggtcac cgtctccagc 600 660 690 <210> 1252 <211> 681 <212> mk <213>人工序列 <220> <223>人工序列之描述·•合成聚核苷酸
<400> 1252 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgcgcag cctccggatt cacctttgag ga^gaggaga tgatttgggt ccgccaggct ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc acttgccggg caagtcgtcc gattgggacg acittaagtt ggtaccagca gaaaccaggg aaagccccta agctcctgat cctttggaac tcccgtttgc aaagtggggt cccatcacgt ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa gattttgcta cgtactactg tgcgcaggct ggiacgcatc ctacgacgtt cggccaaggg accaaggtgg aaatcaaacg g 60 120 180 240 300 360 420 480 540 600 660 681 <210> 1253 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1253 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtca gtggattggg tctcagttat cttggtacca gcagaaacca gggaaagccc ctaagctcct gatcatgtgg cgttcctcgt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct gaagattttg ctacgtacta ctgtgctcag ggtttgaggc atcctaagac gttcggccaa gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga ttcacctttg aggaggagga gatgatttgg gtccgccagg ctccagggaa gggtctagag tgggtctcag ctattagtag gaacggttac agcacatact acgcagactc cgtgaagggc cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg cgtgccgagg ataccgcggt atattactgt gggaaagagc cgtttcgtta tgactactgg ggtcagggaa ccctggtcac cgtctccagc 60 120 180 240 300 360 420 480 540 600 660 690 163920·序列表.doc •553 · 201245225 <210> 1254 <211> 681 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1254 gaggtgcagc tgttggagtc tgg££gaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360 atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420 acttgccggg caagtcagtg gattgggtct cagttatctt ggtaccagca gaaaccaggg 480 aaagccccta agctcctgat catgtggcgt tcctcgttgc aaagtggggt cccatcacgt 540 ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600 gattttgcta cgtactactg tgctcagggt ttgaggcatc ctaa^acgtt cggccaaggg 660 accaaggtgg aaatcaaacg g 681
<210> 1255 <211> 681 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1255
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagcgc ttcaaccgac 360 atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420 acttgccggg caagtcgtcc gattgg£acg acgttaagtt ggtaccagca gaaaccaggg 480 aaagccccta agctcctgat cctttggaat tcccgtttgc aaagtggggt cccatcacgt 540 ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600 gattttgcta cgtactactg tgcgcaggct g££acgcatc ctacgacgtt cggccaaggg 660 accaaggtgg aaatcaaacg g 681 <21Q> 1256 <211> 681 <212> DNA
163920·序列表.doc •554- 201245225 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1256 gaggtgcagc tgttggcgtc tgggggaggc tv.ggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggcc 120 ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat acicgcggtat attactgtgg gaaagagccg 300 tttcgttatg actactgggg tcagggaacc ci:ggtcaccg tctcgagcgc ttcaaccgac 360 atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420 acttgccggg caagtcgtcc gattgggacg al.gttaagtt ggtaccagca gaaaccaggg 480 aaagccccta agctcctgat ccttgctttt tcccgtttgc aaagtggggt cccatcacgt 540 ttcagtggca gtggatctgg gacagatttc acitctcacca tcagcaatct gcaacctgaa 600
gattttgcta cgtactactg cgcgcaggct gj；gacgcatc ctacgacgtt cggccaaggg 660 accaaggtgg aaatcaaacg g 681 <210> 1257 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷睃 <400> 1257 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgacgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatedttgg a^.ttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tlcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acggaccgtg gcggcgccga gtgaggtgca ectgttggcg 360 tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga 420 ttcacctttg aggaggagga gatgatttgg gtccgccagg ctccagggaa gggtctagag 480 tgggtctcag ctattagtag gaacggttac ai；cacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag ag.cacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg ataccgcggt atattactgt gegaaagage cgtttcgtta tgactactgg 660 ggtcagggaa ccctggtcac cgtctccagc 690 <210> 1258 <211> 690 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 -555 - 163920-序列表.doc 201245225 <400> 1258 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acggaccgtg gcggcgccga gtgasgtgca actgttggcg 360 tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga 420 ttcacctttg aggaggagga gatgatttgg gtccgccagg ctccagggaa gggtctagag 480 tgggtctcag ctattagtag gaacggttac agcacatact acgcagactc cgtgaagggc 540 cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600 cgtgccgagg ataccgcggt atattactgt gggaaagagc cgtttcgtta tgactactgg 660 ggtcagggaa ccctggtcac cgtctccagc 690 <210> 1259 <211> 681 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1259
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccfitgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgtacggtg gcggaggtgc agctgttgga gtctggggga 360 ggcttggtac agcctggggg gtccctgcgt ctctcctgtg cagcctccgg attcaccttt 420 cgggattatg agatgtggtg ggtccgccag gctccaggga agggtctaga gcgggtctca 480 gctattaatc cgcagggtac gcgtacatac tacgcagact ccgtgaaggg ccggttcacc 540 atctcccgcg acaattccaa gaacacgctg tatctgcaaa tgaacagcct gcgtgccgag 600 gacaccgcgg tatattactg tgcgaaactt ccgttttact ttcacgagtg gggtcaggga 660 accctg$tca ccgtctccag c 681 <210> 1260 <211> 693 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1260 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120 • 556 · 163920-序列表.doc 201245225 gggaaagccc ctaagctcct gatccttgct tutcccgtt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat tixactctca ccatcagcaa tctgcaacct gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa gggaccaagg tggaaatcaa acgggctagc acxtcaggtc catcggaggt gcagctgttg gagtctgggg gaggcttggt acagcctggg g{；gtccctgc gtctctcctg tgcagcctcc ggattcacct ttcgggatta tgagatgtgg tg;ggtccgcc aggctccagg gaagggtcta gagcgggtct cagctattaa tccgcagggt acgcgtacat actacgcaga ctccgtgaag ggccggttca ccatctcccg cgacaattcc aagaacacgc tgtatctgca aatgaacagc ctgcgtgccg aggacaccgc ggtatattac tgtgcgaaac ttccgtttta ctttcacgag tggggtcagg gaaccctggt caccgtctcc age 180 240 300 360 420 480 540 600 660 693
<210> 1261 <211> 687 <212> 腿 <213>人工序列 <220> <223>人工序列之描述：合成聚核苷2唆 <400> 1261 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa gggaccaagg tggaaatcaa acggggtgga ggtggctctg aggtgcagct gttggagtct gggggaggct tggtacagcc tggggggtcc ct.icgtctct cctgtgcagc ctccggattc acctttcggg attatgagat gtggtgggtc cg:caggctc cagggaaggg tetagagegg gtctcagcta ttaatccgca gggtacgcgt acitactacg cagactccgt gaagggccgg ttcaccatct cccgcgacaa ttccaagaac ac：ictgtatc tgcaaatgaa cagcctgcgt gccgaggaca ccgcggtata ttactgtgcg aaacttccgt tttactttca cgagtggggt cagggaaccc tggtcaccgt ctccagc 60 120 180 240 300 360 420 480 540 600 660 687 <210> 1262 <211> 717 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1262 gacatccaga tgacccagtc tccatcctcc atcacttgcc gggcaagtcg tccgattggg gggaaagccc ctaagctcct gatccttgct cgtttcagtg gcagtggatc tgggacagat ctj;tctgcat ctgtaggaga ccgtgtcacc acgatgttaa gttggtacca gcagaaacca tutcccgtt tgcaaagtgg ggtcccatca ttcactctca ccatcagcaa tctgcaacct 60 120 180 240 163920·序列表.doc -557- 201245225 gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acggggtgga ggtggctctg gaggtggcgg tagcggcgga 360 ggcggttcag aggtgcagct gttggagtct gggggaggct tggtacagcc tggggggtcc 420 ctgcgtctct cctgtgcagc ctccggattc acctttcggg attatgagat gtggtgggtc 480 cgccaggctc cagggaaggg tctagagcgg gtctcagcta ttaatccgca gggtacgcgt 540 acatactacg cagactccgt gaagggccgg ttcaccatct cccgcgacaa ttccaagaac 600 acgctgtatc tgcaaatgaa cagcctgcgt gccgaggaca ccgcggtata ttactgtgcg 660 aaacttccgt tttactttca cgagtggggt cagggaaccc tggtcaccgt ctccagc 717 <210> 1263 <211> 747 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1263 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc g£gcaagtcg tccgattggg acgatgttaa gttgstacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagts gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300 gggaccaasg tggaaatcaa acggggtgga ggtggctctg gaggtggcgg tagcggcggt 360 ggcggttcag gtgscggagg ttctggaggc ggtggatctg aggtgcagct gttggagtct 420 gggggaggct tggtacagcc tggggggtcc ctgcgtctct cctgtgcagc ctccggattc 480 acctttcggg attatgagat gtggtgggtc cgccaggctc cagggaaggg tctagagcgg 540 gtctcagcta ttaatccgca gggtacgcgt acatactacg cagactccgt gaagggccgg 600 ttcaccatct cccgcgacaa ttccaagaac acgctgtatc tgcaaatgaa cagcctgcgt 660 gccgaggaca ccgcggtata ttactgtgcg aaacttccgt tttactttca cgagtg£ggt 720 cagggaaccc tggtcaccgt ctccagc 747
<210> 1264 <2U> 681 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1264
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccga^gac accgcsstat attactgtgc gaaacttccg 300 ttttactttc acgagtgggg tcagggaacc ctggtcaccg tttcgagcac ggtggcggac 360 163920-序列表.doc -558- 201245225 atccagatga cccagtctcc atcctccctg acttgccggg caagtcgtcc gattgggacg aaagccccta agctcctgat ccttgctttt ttcagtggca gtggatctgg gacagatttc gattttgcta cgtactactg cgcgcaggct accaaggtgg aaatcaaacg g tctgcatctg taggagaccg tgtcaccatc aigttaagtt ggtaccagca gaaaccaggg tcccgtttgc aaagtggggt cccatcacgt actctcacca tcagcaatct gcaacctgaa g£：gacgcatc ctacgacgtt cggccaaggg 420 480 540 600 660 681 <210> 1265 <211> 693 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1265 60 120 180 240 300 360 420 480 540 600 660 693
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcacctca ggtccatcgg acatccagat gacccagtct ccatcctccc tgtctgcatc tgtaggagac cgtgtcacca tcacttgccg ggcaagtcgt ccgattggga cgatgttaag ttggtaccag cagaaaccag ggaaagcccc taagctcctg atccttgctt tttcccgttt gcaaagtggg gtcccatcac gtttcagtgg cagtggatct gggacagatt tcactctcac catcagcaat ctgcaacctg aagattttgc tacgtactac tgcgcgcagg ctgggacgca tcctacgacg ttcggccaag ggaccaaggt ggaaatcaaa egg <210> 1266 <211> 687 <212> m <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1266 gaggtgcagc tgttggagtc tgggggaggc ttjgtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc acgagtgggg tcagggaacc ctggtcaccg tetegagegg tggaggegge 360 tctgacatcc agatgaccca gtctccatcc tccctgtctg catctgtagg agaccgtgtc 420 accatcactt gccgggcaag tegteegatt ggj^acgatgt taagttggta ccagcagaaa 480 •559 · 163920·序列表.doc 201245225 ccagggaaag cccctaagct cctgatcctt gctttttccc gtttgcaaag tggggtccca 540 tcacgtttca gtggcastgg atctgggaca gatttcactc tcaccatcag caatctgcaa 600 cctgaagati ttgctacgta ctactgcgcg caggctggga cgcatcctac gacgttcggc 660 caagggacca aggtggaaat caaacgg 687 <210> 1267 <211> 717 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1267
gaggtgcagc tgttggagtc tgggggagsc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc acgagtgggg tcaeggaacc ctggtcaccg tctcgagcgg tggaggtggc 360 tctggaggtg gcggtagcgg cggtggcggt tcagacatcc agatgaccca gtctccatcc 420 tccctgtctg catctgtagg agaccgtgtc accatcactt gccgggcaag tcgtccgatt 480 gggacgatgt taagttggta ccagcagaaa ccagggaaag cccctaagct cctgatcctt 540 gctttttccc gtttgcaaag tggggtccca tcacgtttca gtggcagtgg atctgggaca 600 gatttcactc tcaccatcag caatctgcaa cctgaagatt ttgctacgta ctactgcgcg 660 caggctggga cgcatcctac gacgttcggc caagggacca aggtggaaat caaacgg 717 <210> 1268 <211> 747 <212> DNA <213>人工序列 <220> <223>人工序列之描述：合成聚核苷酸 <400> 1268
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcct£C£ tgccgaggac accgcggtat attactgtgc gaaacttccg 300 ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgs tggaggtggc 360 tctggaggtg gcggtagcgg cggtggcggt tcaggtggcg gaggttctgg aggcggtgga 420 tctgacatcc agatgaccca gtctccatcc tccctgtctg catctgtagg agaccgtgtc 480 accatcactt gccgggcaag tcgtccgatt gggacgatgt taagttggta ccagcagaaa 540 ccagggaaag cccctaagct cctgatcctt gctttttccc gtttgcaaag tggggtccca 600 tcacgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag caatctgcaa 660 -560- 163920·序列表.doc 720201245225 cctgaagatt ttgctacgta ctactgcgcg caigctggga cgcatcctac gacgttcggc caagggacca aggtggaaat caaacgg 747 <210> 1269 <211> 690 <212> <213> DNA 人工序列 <220> <223>人工序列之描述：合成聚核苷酸
<400> 1269 gacatccaga tgacccagtc tccatcctcc ctj；tctgcat ctgtaggaga ccgtgtcacc atcacttgcc gggcaagtcg tccgattggg acj；atgttaa gttggtacca gcagaaacca gggaaagccc ctaagctcct gatccttgct ttr.tcccgtt tgcaaagtgg gfitcccatca cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct gaagattttg ctacgtacta ctgcgcgcag gci:gggacgc atcctacgac gttcggccaa gggaccaagg tggaaatcaa acggaccgta gc{：gcgccga gtgaggtgca gctgttggag tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg cgtgccgagg acaccgcggt atattactgt gcg;aaacttc cgttttactt tcacgagtgg ggtcagggaa ccctggtcac cgtctccagc 60 120 180 240 300 360 420 480 540 600 660 690 <210> 1270 <211> 44 <212> PRT <213>人工序列 <220> <223>人工序列之描述··合成多肽 <400> 1270 Cys Scr Pro Gly Phe Gly Val Lys Gin lie Ala Thr Gly Val Ser Asp 15 10 15
Thr lie Cys Glu Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser 20 25 30
Ala Phe Glu Lys Cys His Pro Trp Ser Cys Glu <210> 1271 <211> 44 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1271 Cys Ser Pro Gly Tyr Arg Val Lys Glu Ala Cys Gly Glu Leu Thr Gly 1 5 10 15 163920-序列表.d〇c -561 - 201245225
Thr Val Cys Glu Pro Cys Pro Pro Gly Thr Tyr lie Ala His Leu Asn 20 25 30
Gly Leu Ser Lys Cys Leu Gin Cys Gin Met Cys Asp 35 40 <210> 1272 <211> 44 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1272
Cys Gin Pro Gly Gin Lys Leu Val Ser Asp Cys Thr Glu Phe Thr Glu 15 10 15
Thr Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp Asn 20 25 30
Arg Glu Thr His Cys His Gin His Lys Tyr Cys Asp 35 40 <210> 1273 <211> 19 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <400> 1273
Asp Pro Gly Gly Gly Gly Gly Arg Leu Val Pro Arg Gly Phe Gly Thr 15 10 15
Gly Asp Pro <210> 1274 <211> 5 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <220> <221> MOD RES <222> (1)7.(1) <2b> As^)或Gly <220> <221> MOD RES <222> (4)7,(4) <223> Met 或Leu <400> 1274
Xaa Tyr Glu Xaa Trp 1 5 163920·序列表.doc - 562 -
201245225 <210> 1275 <211> 17 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <220> <221> M0D.RES <222> (5)..(5) <223> Gin、Tyr、Pro、Trp 或 Ala <220> <221> MOD RES <222> (7)..(7) <223> Tlir、Ser、Asn、Gly、Met或Gin <220>
<221> ra.RES <222> (8)..(8) <223> Ajrg、Leu ' Tyr、His 或Phe <220>
<221> MOD.RES <222> (16)..(16) <223> Lys 或Ivlet <400> 1275
Ala lie Asn Pro Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val Xaa 15 10 15
Gly <210> 1276 <211> 7 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <220>
<221> MOD RES <222> (1)..(1) <223> teu 或Pro <220> <221> M0D.RES <222> (3)..(3) <223> Phe、Gin、Thr 或Met <220> <221> W3D RES <222> (4)..(4) <223> Tyr、Pro、Leu、Thr、lie、Phe 或Met <220>
<221> MOD RES <222> (6)..(6) <223> όΐη、His、Asp、Ser、Lys、Glu 或 Gly <220> <221> MOD RES <222> (7)..(7) <223> Glu、Asp 或Tyr <400> 1276 -563 - 163920-序列表.doc 201245225
Xaa Pro Xaa Xaa Phe Xaa Xaa <210> 1277 <211> 30 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <220> <221> MOD RES <222> (18)..(18) <223> Leu或Arg <220〉 <221> MC» RES <222> (30)..(30) <223> Arg 或人la <400> 1277
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Xaa Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa 20 25 30 <210> 1278 <211> 14 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <220> <221> MOD RES <222> (4)..(4) <223> όΐη或Arg <220> <221> MOD RES <222> (8)..(8) <223> Lys 或Arg <220> <221> MOD RES <222> (9)..(9) <223> Gly 或 Val <400> 1278
Trp Val Arg Xaa Ala Pro Gly Xaa Xaa Leu Glu Arg Val Ser <210> 1279 <211> 32 <212> PRT <213>人工序列 <220> <223>人工序列之描述··合成多肽 <220>
<221> M0D.RES 564-
163920·序列表.doc 201245225 <222> (12)..(12) <223> Thr或Met <220> <221〉MOD RES <222> (23)..(23) <223> 01u 或Xsp <220> <221> M0D.RES <222> (26)..(26) <223> Ala 或 Ser <220> <221> M0D.RES <222> (29)..(29) <223> Tyr或His <220> <221> MOD RES <222> (31*)..(31) <223> Ala 或Thr <400> 1279
Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Xaa Lys Tyr Leu Gin 15 10 15
Met Asn Ser Leu Arg Ala Xaa Asp Thr Xaa Val Tyr Xaa Cys Xaa Lys 20 25 30 <210> 1280 <211> 11 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成肽 <220> <221> MOD RES <222> (1)..(1) <223> Trp 或 Arg <220> <221> MOD RES <222> (3)..(3) <223> Gin 或Ριό <220> <221> MOD RES <222> (11)..(11) <223> Ser或Asn <400> 1280
Xaa Gly Xaa Gly Thr Leu Val Thr Val Ser Xaa 1 5 10 <210> 1281 <211> 116 <212> PRT <213>人工序列 <220〉 <223>人工序列之描述：合成多肽 <220> <221> MOD RES <222> (13)..(13) -565 - 163920-序列表.doc 201245225 <223> Gin或Arg <220> <221> M0D.RES <222> (99)..(99) <223> Glu 或 Gly <22Q> <221> MOD RES <222> (101)..(101) <223〉Ala、Leu 或Glu <220> <221> M0D.RES <222> (102)..(102) <223> Phe 或Tyr <220> <221〉 MOD RES <222> (106)..(106) <223> Trp^Aig <400> 1281
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Xaa Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
Glu Met Gin Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala lie Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Xaa Leu Xaa Xaa Phe Asp Tyr Xaa Gly Arg Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 1282 <211> 116 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <220> <221> MOD RES <222> (28)..(28) <223> Thr或Pro <220> <221> MOD RES <222> (50)..(50) <223> Ala ic* Ser 163920-序列表.doc 566-
201245225 <220> <221> MOD RES <222> (53)..(53) <223> Arg或 01y <220> <221> MOD_RES <222> (54)..(54) <223> Arg、5er、Asn、Gin、Gly、F[is 或Leu <220> <221> MOD.RES <222> (56)..(56) <223> iTyr、Phe、Trp 或 Gly <220> <221> MOD.RES <222> (57)..(57) <223> Ser 或 Gly <220> <221> MOD RES <222> (102)..(102) <223〉Arg、Met 或Pro <400> 1282
Glu Val Gin Leu Leu Ala Ser Gly Gly Gly Leu Va] Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Xaa Phe Glu Glu Glu 20 25 30
Glu Met lie Trp Val Arg Gin Ala Prc Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Xaa lie Ser Xaa Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Gly Lys Glu Pro Phe Xaa Tyr Asp Tyr Trp Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> 1283 <211> 118 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <220> <221> M0D.RES <222> (36)..(36) <223> Met 或Leu <220>
<221> mDJSS 567 - 163920-序列表.doc 201245225 <222> (39)..(39) <223> Val 或Phe <220> <221> MOD RES <222> (76)..(76) <223> Asp 或Asn <220> <221> MOD.RES <222> (77)..(77) <223> Ser或Τΐιτ <220> <221> MOD RES <222> (97)..(97) <223> T>r或His <220> <221> MOD RES <222> (100)..(100) <223> Lys 或Arg <220> <221> MOD.RES <222〉 （101)..(101) <223> Asp^Glu <220> <221> MOD RES <222> (105)..(105) <223> Tyr^Phe <220> <221> MOD RES <222> (108),.(108) <223> Tip 或Arg <220> <221> M0D.RES <222> (109)..(109) <223> Gly^Arg <220> <221> MOD_RES <222> (1ΐϋ)..(110) <223> Gin 或His <400> 1283
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Thr 20 25 30
Arg Tyr Glu Xaa Trp Trp Xaa Arg Gin Ala Pro Gly Lys Gly Leu Glu 35 40 45
Arg Val Ser Ala lie Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 50 55 60
Ser Val Lys Gly Arg Phe Thr He Ser Arg Asp Xaa Xaa Lys Asn Thr 65 70 75 80
Leu Tyr Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95
Xaa Cys Ala Xaa Xaa Pro Tyr Ser Xaa Asp Tyr Xaa Xaa Xaa Gly Thr 100 105 110 •568- 163920·序列表.doc 201245225
Leu Val Thr Val Ser Ser 115 <210〉 1284 <2ll> 232 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1284
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 15 10 15
Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30
Lys Asp Thr Leu Met lie Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gin 65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gin 85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100 105 110
Leu Pro Ala Pro lie Glu Lys Thr lie Ser Lys Ala Lys Gly Gin Pro 115 120 125
Arg Glu Pro Gin Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140
Lys Asn Gin Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160
Asp lie Ala Val Glu Trp Glu Ser Asn Gly Gin Pro Glu Asn Asn Tyr 165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gin Gin Gly Asn Val Phe 195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gin Lys 210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys 225 230 569- 163920-序列表.doc 201245225 <210> 1285 <211> 229 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1285
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 15 10 15
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 20 25 30
Leu Met lie Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 35 40 45
Ser Gin Glu Asp Pro Glu Val Gin Phe Asn Trp Tyr Val Asp Gly Val 50 55 60
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gin Phe Asn Ser 65 70 75 80
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gin Asp Trp Leu 85 90 95
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 100 105 110
Ser lie Glu Lys Thr lie Ser Lys Ala Lys Gly Gin Pro Arg Glu Pro 115 120 125
Gin Val Tyr Thr Leu Pro Pro Ser Gin Glu Glu Met Thr Lys Asn Gin 130 135 140
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp lie Ala 145 150 155 160
Val Glu Trp Glu Ser Asn Gly Gin Pro Glu Asn Asn Tyr Lys Thr Thr 165 170 175
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 180 185 190
Thr Val Asp Lys Ser Arg Trp Gin Glu Gly Asn Val Phe Ser Cys Ser 195 200 205
Val Met His Glu Ala Leu His Asn His Tyr Thr Gin Lys Ser Leu Ser 210 215 220
Leu Ser Leu Gly Lys 225 <210> 1286 <211> 351 <212> PRT <213>人工序列 -570-
163920·序列表.doc 201245225 <220> <223>人工序列之描述：合成多肽 <400> 1286
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45'
Ser Ala lie Asn Pro Gin Gly Thr kr\i Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg As]) Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Arg Phe Ser Asp Arg Gly Gin Gly Thr Leu Val 100 10i; 110
Thr Val Ser Ser Ala Ser Thr Glu Prc Lys Ser Ser Asp Lys Thr His 115 120 125
Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 130 135 140
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met lie Ser Arg Thr 145 150 155 160
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 165 170 175
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 180 185 190
Thr Lys Pro Arg Glu Glu Gin Tyr Asn Ser Thr Tyr Arg Val Val Ser 195 200 205
Val Leu Thr Val Leu His Gin Asp Trp Leu Asn Gly Lys Glu Tyr Lys 210 215 220
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro lie Glu Lys Thr lie 225 230 235 240
Ser Lys Ala Lys Gly Gin Pro Arg Glu Pro Gin Val Tyr Thr Leu Pro 245 250 255
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gin Val Ser Leu Thr Cys Leu 260 265 270
Val Lys Gly Phe Tyr Pro Ser Asp lie Ala Val Glu Trp Glu Ser Asn -571 - 163920-序列表.doc 201245225 275 280 285
Gly Gin Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 290 295 300
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 305 310 315 320
Trp Gin Gin Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 325 330 335 .
His Asn His Tyr Thr Gin Lys Ser Leu Ser Leu Ser Pro Gly Lys 340 345 350 <210> 1287 <211> 348 <212> PRT <213>人工序列 <220> <223>人工序列之描述：合成多肽 <400> 1287
Glu Val Gin Leu Leu Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Gly 15 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30
Glu Met Trp Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Arg Val 35 40 45
Ser Ala lie Asn Pro Gin Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Leu Pro Phe Arg Phe Ser Asp Arg Gly Gin Gly Thr Leu Val 100 105 110
Thr Val Ser Ser Ala Ser Thr Glu Ser Lys Tyr Gly Pro Pro Cys Pro 115 120 125
Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 130 135 140
Pro Pro Lys Pro Lys Asp Thr Leu Met lie Ser Arg Thr Pro Glu Val 145 150 155 160
Thr Cys Val Val Val Asp Val Ser Gin Glu Asp Pro Glu Val Gin Phe 165 170 175
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 180 185 190 -572·
163920-序列表.doc 201245225
Arg Glu Glu Gin Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 195 200 205
Val Leu His Gin Asp Trp Leu Asn Gl/ Lys Glu Tyr Lys Cys Lys Val 210 215 220
Ser Asn Lys Gly Leu Pro Ser Ser Ι1«ϊ Glu Lys Thr lie Ser Lys Ala 225 230 235 240
Lys Gly Gin Pro Arg Glu Pro Gin Vai Tyr Thr Leu Pro Pro Ser Gin 245 250 255
Glu Glu Met Thr Lys Asn Gin Val Se:: Leu Thr Cys Leu Val Lys Gly 260 26：i 270
Phe Tyr Pro Ser Asp lie Ala Val Glu Trp Glu Ser Asn Gly Gin Pro 275 280 285
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 290 295 300
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gin Glu 305 310 315 320
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 325 330 335
Tyr Thr Gin Lys Ser Leu Ser Leu Ser Leu Gly Lys 340 345 -573 - 163920-序列表.doc

Claims (1)

  1. 201245225 七、申請專利範圍： 1. 一種包含第一可變域之抗體多肽，其中該抗體多肽特異 性結合人類CD40之抗原決定基，其中該抗體多肽與域抗 體（domain antibody，dAb) BMS3h-56-269 (SEQ ID NO: 417)競爭結合於CI)40，其中CD40包含SEQ ID NO: 1之胺 基酸序列，且其中該抗原決定基包含至少一個選自由 Trpl09、Leul21、Hisl22、Serl24、Serl56、Alal57、 Phel58、Glul59及Hisl62組成之群的CD40胺基酸殘基。
    2. 如請求項1之抗體多肽，其中該第一可變域包含選自由 BMS3h-37、BMS3h-38、BMS3h-56及 BMS3h-198 組成之 系群的抗體多肽之一之胺基酸序列，且其中該第一可變 域之表觀結合常數為1 pM至100 nM。 3. 如請求項1至2中任一項之抗體多肽，其中該第一可變域 包含選自由BMS3h-37、BMS3h-38及BMS3h-56組成之系 群的抗體多肽之一之胺基酸序列，且其中該第一可變域 之hIZCD40L驅動之人類B細胞增殖EC5〇為0.01 nM至 100.0 nM。 4. 如請求項1之抗體多肽，其中該第一可變域之胺基酸序 列包含： (a) 與 BMS3h-56-269 (SEQ ID NO: 417)之 CDR1區有至 多兩個胺基酸不同的CDR1區， (b) 與 BMS3h-56-269 (SEQ ID NO: 417)之 CDR2 區有至 多兩個胺基酸不同的CDR2區， (c) 與BMS3h-56-269 (SEQ ID NO: 417)之CDR3區有至 163920.doc 201245225 多兩個胺基酸不同的CDR3區， (d) 與 BMS3h-56-269 (SEQ ID NO: 417)之 FR1 區有至多 兩個胺基酸不同的FR1區， (e) 與BMS3h-56-269 (SEQ ID NO: 417)之FR2區有至多 兩個胺基酸不同的FR2區， (f) 與 BMS3h-56-269 (SEQ ID NO: 417)之 FR3 區有至多 兩個胺基酸不同的FR3區，及 (g) 與BMS3h-56-269 (SEQ ID NO: 417)之FR4區有至多 兩個胺基酸不同的FR4區。 5. 如請求項1之抗體多肽，其中該第一可變域之胺基酸序 列包含： (a) 與 BMS3h-56-269 (SEQ ID NO: 417)之 CDR1區有至 多兩個胺基酸不同的CDR1區， (b) 與 BMS3h-56-269 (SEQ ID NO: 417)之 CDR2 區有至 多兩個胺基酸不同的CDR2區， (c) 與 BMS3h-56-269 (SEQ ID NO: 417)之 CDR3 區有至 多兩個胺基酸不同的CDR3區。 6. 如請求項1之抗體多肽，其中該第一可變域之胺基酸序 列與 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列有至多10個胺基酸不 同。 7. 如請求項6之抗體多肽，其中該第一可變域之胺基酸序 列與 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列有至多5個胺基酸不同。 163920.doc 201245225 8·如請求項7之抗體多肽’其中該第一可變域之胺基酸序 列與 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列有兩個胺基酸不同。 9.如請求項8之抗體多肽，其中該第一可變域之胺基酸序 列與 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列有一個胺基酸不同。 10·如請求項2至3中任一項之抗體多肽，其中該抗體多肽係 選自BMS3h-56之系群，且其中該第一可變域之胺基酸序
    列進一步包含： ⑷具有序列 X丨-Tyr-Glu-Y丨-Trp (SEQ ID NO: 1274)之 CDR1區，其中XAAsp 或 Gly，且 YAMet 或 Leu; (b) 具有序列 Ala-Ile-Asn-Pro-X2_Gly-Y2-Z2-Thr-Tyr-Tyr· Ala-Asp-Ser-Val-A2-Gly (SEQ ID NO: 1275)之 CDR2 區，其中 X2 為 Gin、Tyr、Pro、Trp 或 Ala，Y2 為 Thr、 Ser、Asn、Gly、Met 或 Gin，Z2為 Arg、Leu、Tyr、His 或Phe，且A2為Lys或Met ;及 (c) 具有序列X3-Pro-Y3-Z3-Phe-A3-B3(SEQ ID NO: 1276) 之 CDR3 區，其中 X3 為 Leu 或 Pro，Y3 為 Phe、Gin、Thr 或 Met，Z3 為 Tyr、Pro、Leu、Thr、lie、Phe 或 Met， A3 為 Gin、His、Asp、Ser、Lys、Glu 或 Gly，且 B3 為 Glu、Asp 或 Tyr。 11·如請求項l〇之抗體多肽，其中該第一可變域之胺基酸序 列包含： (a)具有序列 Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly- 163920.doc 201245225 Leu-Val-Gln-Pro-Gly-Gly-Ser-Xj-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Y, (SEQ ID NO: 1277)之FR1 區，其中X〗為Leu或Arg，且Y丨為Arg或Ala; (b)具有序列1'叩-\^1-八巧-乂2-八18-?1>〇-01;/-丫2-22-1^11-0111-Arg-Val-Ser (SEQ ID NO: 1278)之 FR2 區，其中 X2 為 Gin 或 Arg，Y2 為 Lys 或 Arg，且 Z2 為 Gly 或 Val ; (C)具有序列入巧-?116-1'1111-116-861>八1§-八3卩-八511-861>-1^3_八511-X3-Lys-Tyr-Leu-Gin-Met-Asn-Ser-Leu-Arg-Ala-Y3-Asp-Thr-Z3-Val-Tyr-A3-Cys-B3-Lys (SEQ ID NO: 1279)之 FR3 區，其中 X3 為 Thr 或 Met，Y3 為 Glu或 Asp，Z3為 Ala 或 Ser，A3 為 Tyr 或 His，且 B3 為 Ala或 Thr ;及 (d)具有序列 X4-Gly-Y4-Gly-Thr-Leu-Val-Thr-Val-Ser-Z4 (SEQ ID NO: 1280)之 FR4 區，其中 X4為 Trp或 Arg，Y4 為 Gin 或 Pro，且 Z4 為 Ser 或 Asn。 12·如請求項2至3中任一項之抗體多肽，其中該第一可變域 包含 BMS3h-56-258 (SEQ ID NO: 10)或 BMS3h-56-269 (SEQ ID NO: 417)之胺基酸序列。 13.如請求項2至3中任一項之抗體多肽，其中該抗體多肽係 選自BMS3h-3 7之系群，其中該第一可變域包含序列〇111-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Xi-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Glu-Trp-Tyr-Glu-Met-GIn-Trp-Val-Arg-Arg-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser-Ala-Ile-Ser-Gly-Asp-Gly-Tyr-Arg-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly- 163920.doc •4- 201245225 Arg-Phe-Thr-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Tyr-Cys-Ala-Lys-Yj-Leu-Z^Aj-Phe-Asp-Tyr-B i-Gly-Arg-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (SEQ ID NO: 1281);且 其中Xi為Gin或Arg ; YigGlu或Gly;乙1為八1&、Leu或 Glu ;八丨為卩!^或Tyr ;且仏為！^或Arg。
    14.如請求項2至3中任一項之抗體多肽，其中該抗體多肽係 選自BMS3h-38之系群，其中該第一可變域包含序列〇111-Val-Gln-Leu-Leu-Ala-Ser-Gly-Gly-Gly-Leu-Yal-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Xi-Phe-Glu-Glu-Glu-Glu-Met-Ile-Trp-Val-Arg-Gln-Ala- Pro-Gly-Lys-Gly-L,eu-Glu-Trp-Val-Ser-Y i-Ile-Ser-Z^Ai-Gly-Bi-Ci-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-A]*g-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-L eu-Gin-Met-Asn-Ser-L eu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Tyr-Cy s-Gly-I,y s-Glu-Pro-Phe-D i - Tyr-Asp-Tyr-Trp-Gly-Gln-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (SEQ ID NO: 1282);且 其中 乂1為1'111* 或 Pro ; 丫1為 Ala 或 Ser ;乙,為 Arg 或 Gly ; Αι 為 Arg、Ser、Asn、Gin、Gly、His 或 Leu ; B1g Tyr、 Phe、Trp 或 Gly ; Ci 為 Ser 或 Gly ;且 Di 為 Arg、Met 或 Pro 〇 15.如請求項2至3中任一項之抗體多肽，其中該抗體多肽係 I63920.doc 201245225 選自BMS3h-198之系群，其中該第一可變域包含序列 Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Ala-Gly-Try-Glu-X^Trp-Trp-Y^Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Arg-Val-Ser-Ala-Ile-Ser-Gly-Ser-Gly-Gly-Ser-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Zi-Ai-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-B i-Cys-Ala-Ci-Di-Pro-Tyr-Ser-Ei-Asp-Tyr- F,-G,-H,-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (SEQ ID NO: 1283);且 其中 Xi 為 Met或 Leu ; Yi 為 Val 或 Phe ; Zi 為 Asp或 Asn ; Ai為Ser或Thr ; B丨為Tyr或His ; C丨為Lys或Arg ; D丨為Asp 或 Glu，E 丨為 Tyr 或 Phe ; Fi 為 Trp 或 Arg ; G 丨為 Gly 或 Arg ; 且Hi為Gin或His 〇 16. 如請求項i至15中任一項之抗體多肽，其中該抗體多肽 為域抗體（dAb)。 17. 如請求項1至丨6中任一項之抗體多肽，其中該抗體多肽 為包含該第一可變域及Fc域之融合多肽》 18. 如請求項17之融合多肽，其中該融合多肽包含IgG4 Fc 域。 19·如請求項丨8之融合多肽，其中該融合多肽包含IgGi Fc 域0 20.如請求項17至19中任一項之融合多肽，其中該融合多肽 163920.doc • 6- 201245225 包含選自由BMS3h-37、BMS3h-38及BMS3h-56組成之系 群的抗體多肽之一之胺基酸序列，且其中該融合多肽之 hIZCD40L驅動之人類B細胞增殖EC5。為0.001 nM至100.0 nM 〇 21. 如請求項1至20中任一項之抗體多肽，其中該抗體多肽 進一步包含特異性結合第二抗原之第二可變域，其中該 第二抗原為除人類CD40以外之抗原。 22. 如請求項21之抗體多肽’其中該第二抗原為分化簇 0 (cluster of differentiation，CD)分子或主要組織相容性複 合體（Major Histocompatibility Complex，MHC) II類分 子。 23. 如請求項21之抗體多肽，其中該第二抗原為血清白蛋白 (SA) 〇 24· —種核酸，其編碼如請求項1至23中任一項之抗體多 肽。 25. —種載體’其包含如請求項24之核酸。 26. —種經分離之宿主細胞，其包含如請求項25之載體。 27_ —種醫藥組合物，其包含治療有效量之如請求項丨之抗 體多肽及醫藥學上可接受之載劑。 28.如請求項27之醫藥組合物，其進一步包含免疫抑制/免疫 調節劑及/或消炎劑。 29· -種治療需要該治療之患者的免疫疾病之方法，其包含 向該患者投與治療有效量之如請求項27之醫藥組合物。 3 0.如睛求項29之方法，其中該醫藥組合物係與免疫抑制/免 163920.doc 201245225 疫調節劑及/或消炎劑組合投與β 31. 32. 如請求項29之方法，其中該免疫疾病為自體免疫疾病或 移植相關疾病β 如請求項29之方法’其中該免疫疾病係選自由以下組成 之群.又迪森氏病（Addison’s disease)、過敏症、僵直性 脊椎炎、哮喘、動脈粥樣硬化、自體免疫性耳病、自體 免疫性眼病、自體免疫肝炎、自體免疫腮腺炎、結腸 炎、冠心病、克羅恩氏病（Crohn’s disease)、糖尿病（包 括1型及/或2型糖尿病）、附睪炎、絲球體腎炎、葛瑞夫 茲氏病（Graves’ disease)、格-巴二氏徵候群（Guillain_ Barre syndrome)、橋本氏病（Hashimoto’s disease)、溶血 性貧血、特發性血小板減少性紫癜、發炎性腸病、對重 組藥品之免疫反應、全身性紅斑狼瘡、男性不育症、多 發性硬化症、重症肌無力、天疱瘡、牛皮癖、風濕熱、 類風濕性關節炎、類肉瘤病、硬皮病、休格連氏症候群 (Sjogten’s syndrome)、脊椎關節病、甲狀腺炎、移植排 斥反應、血管炎、AIDS、異位性過敏症、支氣管哮喘、 濕疹、麻風病、精神分裂症、遺傳性抑鬱症、組織及器 官之移植、慢性疲勞症候群、阿茲海默氏病（Alzheimer's disease)帕金森氏病（Parkinson’s disease)、心肌梗塞、 中風、自閉症、癲癇症、阿瑟氏現象（Arthus's phenomenon)、全身性過敏反應、酒精成癮及藥物成 癮。 163920.doc
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