TW201202241A - Chemical compounds - Google Patents
Chemical compounds Download PDFInfo
- Publication number
- TW201202241A TW201202241A TW100109800A TW100109800A TW201202241A TW 201202241 A TW201202241 A TW 201202241A TW 100109800 A TW100109800 A TW 100109800A TW 100109800 A TW100109800 A TW 100109800A TW 201202241 A TW201202241 A TW 201202241A
- Authority
- TW
- Taiwan
- Prior art keywords
- amine
- dihydro
- ethenyl
- indol
- cancer
- Prior art date
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 85
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- LIVYKAHFQBZQRL-UHFFFAOYSA-N thieno[3,2-c]pyridin-4-amine Chemical compound NC1=NC=CC2=C1C=CS2 LIVYKAHFQBZQRL-UHFFFAOYSA-N 0.000 claims description 9
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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| CN108003163A (zh) * | 2017-11-30 | 2018-05-08 | 武汉中钰钰民医药科技有限公司 | 用作激酶抑制剂的吡唑并嘧啶类化合物及其应用 |
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| US8598156B2 (en) | 2010-03-25 | 2013-12-03 | Glaxosmithkline Llc | Chemical compounds |
| WO2012158123A1 (en) * | 2011-05-13 | 2012-11-22 | Agency For Science, Technology And Research | Compounds and methods for treating insulin resistance syndrome |
| ES2950569T3 (es) | 2011-07-19 | 2023-10-11 | Merck Sharp & Dohme | (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| US9550750B2 (en) | 2012-10-05 | 2017-01-24 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitors |
| TWI498325B (zh) * | 2013-01-18 | 2015-09-01 | Hoffmann La Roche | ３－取代吡唑及其用途 |
| ES2638317T3 (es) * | 2013-04-04 | 2017-10-19 | Janssen Pharmaceutica Nv | Nuevos derivados de N-(2,3-dihidro-1H-pirrolo[2,3-b]piridin-5-il)-4-quinazolinamina y N-(2,3-dihidro-1H-indol-5-il)-4-quinazolinamina como inhibidores de PERK |
| TWI482757B (zh) * | 2013-10-07 | 2015-05-01 | Luminescence Technology Corp | Ｖｅｇｆ－２／３受體及蛋白質酪胺酸激酶抑制劑及其醫藥用途 |
| WO2015056180A1 (en) * | 2013-10-15 | 2015-04-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Indoline derivatives as inhibitors of perk |
| BR112016012794A2 (pt) | 2013-12-05 | 2017-08-08 | Acerta Pharma Bv | Combinação terapêutica de um inibidor de pi3k e um inibidor de btk |
| US10272083B2 (en) | 2014-01-21 | 2019-04-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor |
| WO2015136463A1 (en) * | 2014-03-11 | 2015-09-17 | Glaxosmithkline Intellectual Property (No.2) Limited | Chemical compounds acting as perk inhibitors |
| US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
| US9949971B2 (en) | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
| RS62713B1 (sr) | 2014-08-11 | 2022-01-31 | Acerta Pharma Bv | Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora |
| LT3461821T (lt) | 2014-10-24 | 2020-08-10 | Bristol-Myers Squibb Company | Indolo karboksamido junginiai, naudotini kaip kinazės inhibitoriai |
| EA039885B1 (ru) | 2014-11-14 | 2022-03-23 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Производные 6-амино-7-бицикло-7-деазапурина в качестве ингибиторов протеинкиназы |
| WO2016126026A2 (ko) * | 2015-02-04 | 2016-08-11 | 서울대학교병원 | 당뇨병 치료 조성물 및 이의 용도 |
| JP6829215B2 (ja) | 2015-07-02 | 2021-02-10 | アセルタ ファーマ ビー．ブイ． | （Ｓ）−４−（８−アミノ−３−（１−（ブト−２−イノイル）ピロリジン−２−イル）イミダゾ［１，５−ａ］ピラジン−１−イル）−Ｎ−（ピリジン−２−イル）ベンザミドの固体形態及び製剤 |
| TW201722957A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產（第二）有限公司 | 化學化合物 |
| WO2017046739A1 (en) * | 2015-09-15 | 2017-03-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Imidazolidinone derivatives as inhibitors of perk |
| IL295649B2 (en) * | 2016-04-07 | 2025-12-01 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides useful as protein modulators |
| EP3960180A1 (en) * | 2016-04-15 | 2022-03-02 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
| WO2017189837A1 (en) * | 2016-04-29 | 2017-11-02 | The Trustees Of The University Of Pennsylvania | Protein kinase rna-like endoplasmic reticulum kinase (perk) inhibitors for prevention and/or treatment of lung injury and/or inflammation |
| EP3472133B1 (en) | 2016-06-13 | 2023-10-11 | Ramot at Tel-Aviv University Ltd. | Perk inhibitors and uses thereof in treating diseases associated with aggregation-prone proteins |
| US10561660B2 (en) | 2016-06-21 | 2020-02-18 | Nerviano Medical Sciences S.R.L. | N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors |
| EP3487503A1 (en) * | 2016-07-20 | 2019-05-29 | GlaxoSmithKline Intellectual Property Development Limited | Isoquinoline derivatives as perk inhibitors |
| US11759437B2 (en) | 2016-09-22 | 2023-09-19 | The University Of Hong Kong | Preventive and therapeutic approach for aberrant cell differentiation and ISR-associated diseases |
| EP3573608A1 (en) | 2017-01-30 | 2019-12-04 | Université de Liège | Perk and ire-1a inhibitors against neurodevelopmental disorders |
| CN106974910B (zh) * | 2017-03-02 | 2019-11-12 | 深圳大学 | 含索拉非尼和gsk2656157的药物组合物及用途 |
| CN106963769B (zh) * | 2017-03-03 | 2019-10-25 | 深圳大学 | 含pi3k抑制剂和perk抑制剂的药物组合物及其应用 |
| PT3593817T (pt) * | 2017-03-06 | 2024-12-17 | Tsubota Lab Inc | Composição para a utilização na prevenção ou supressão da miopia |
| US11014927B2 (en) * | 2017-03-20 | 2021-05-25 | Forma Therapeutics, Inc. | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators |
| WO2019021208A1 (en) * | 2017-07-27 | 2019-01-31 | Glaxosmithkline Intellectual Property Development Limited | USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS |
| MX2020004557A (es) | 2017-11-02 | 2020-10-05 | Calico Life Sciences Llc | Moduladores de la vía de estrés integrada. |
| CN111100130B (zh) * | 2018-10-29 | 2022-07-15 | 四川大学 | 4-氨基吡咯并嘧啶衍生物及其制备方法和用途 |
| CN111213632B (zh) * | 2019-11-19 | 2022-03-01 | 长春中医药大学 | 动物药环氧树脂标本制作方法 |
| KR20230035311A (ko) | 2020-06-08 | 2023-03-13 | 할리아 테라퓨틱스, 인코포레이티드 | Nek7 키나제의 억제제 |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| US20240382488A1 (en) | 2021-03-29 | 2024-11-21 | Halia Therapeutics, Inc. | Nek7 inhibitors |
| MX2023011464A (es) | 2021-04-05 | 2023-10-19 | Halia Therapeutics Inc | Inhibidores de la cinasa relacionada con el gen nunca en mitosis a 7 (nek7). |
| WO2023034236A1 (en) * | 2021-08-31 | 2023-03-09 | Wisconsin Alumni Research Foundation | Deuterated inhibitors of rip kinases |
| GB202407386D0 (en) | 2024-05-24 | 2024-07-10 | Apollo Ap45 Ltd | 1H-pyrazolo(4,3-D)pyrimidine derivatives |
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Cited By (1)
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| CN108003163A (zh) * | 2017-11-30 | 2018-05-08 | 武汉中钰钰民医药科技有限公司 | 用作激酶抑制剂的吡唑并嘧啶类化合物及其应用 |
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| EP2549868A4 (en) | 2013-08-07 |
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| JP5876031B2 (ja) | 2016-03-02 |
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