CN108003163A - 用作激酶抑制剂的吡唑并嘧啶类化合物及其应用 - Google Patents
用作激酶抑制剂的吡唑并嘧啶类化合物及其应用 Download PDFInfo
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- CN108003163A CN108003163A CN201711244216.2A CN201711244216A CN108003163A CN 108003163 A CN108003163 A CN 108003163A CN 201711244216 A CN201711244216 A CN 201711244216A CN 108003163 A CN108003163 A CN 108003163A
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- cycloalkyl
- alkynyl
- alkenyl
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- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
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- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物 | LD50(mg/kg) | 95%可信限 |
式1所示化合物 | 168.9 | 104.0-118.5 |
Claims (10)
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1960993A (zh) * | 2004-04-02 | 2007-05-09 | Osi制药公司 | 6,6-双环取代的杂双环蛋白激酶抑制剂 |
CN101389630A (zh) * | 2005-12-29 | 2009-03-18 | 艾博特公司 | 蛋白激酶抑制剂 |
TW201202241A (en) * | 2010-03-25 | 2012-01-16 | Glaxosmithkline Llc | Chemical compounds |
WO2016123151A1 (en) * | 2015-01-26 | 2016-08-04 | University Of Washington | Bumped kinase inhibitor compositions and methods for treating cancer |
-
2017
- 2017-11-30 CN CN201711244216.2A patent/CN108003163B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1960993A (zh) * | 2004-04-02 | 2007-05-09 | Osi制药公司 | 6,6-双环取代的杂双环蛋白激酶抑制剂 |
CN101389630A (zh) * | 2005-12-29 | 2009-03-18 | 艾博特公司 | 蛋白激酶抑制剂 |
TW201202241A (en) * | 2010-03-25 | 2012-01-16 | Glaxosmithkline Llc | Chemical compounds |
WO2016123151A1 (en) * | 2015-01-26 | 2016-08-04 | University Of Washington | Bumped kinase inhibitor compositions and methods for treating cancer |
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