TW201200524A - Spiro isoxazoline compounds as SSTR5 antagonists - Google Patents

Info

Publication number

TW201200524A

TW201200524A TW100117097A TW100117097A TW201200524A TW 201200524 A TW201200524 A TW 201200524A TW 100117097 A TW100117097 A TW 100117097A TW 100117097 A TW100117097 A TW 100117097A TW 201200524 A TW201200524 A TW 201200524A

Authority

TW

Taiwan

Prior art keywords

substituted

group

doc

mmol

halogen

Prior art date

2010-05-18

Links

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• -1 Spiro isoxazoline compounds Chemical class 0.000 title claims description 148
• 239000005557 antagonist Substances 0.000 title abstract description 25
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 184
• 125000000217 alkyl group Chemical group 0.000 claims description 141
• 229910052736 halogen Inorganic materials 0.000 claims description 112
• 125000003118 aryl group Chemical group 0.000 claims description 110
• 150000003839 salts Chemical class 0.000 claims description 99
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 95
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 82
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• 125000001424 substituent group Chemical group 0.000 claims description 42
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• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical class NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 25
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