TW201004954A - Solid dosage formulations of telcagepant potassium - Google Patents
Solid dosage formulations of telcagepant potassium Download PDFInfo
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- TW201004954A TW201004954A TW098121909A TW98121909A TW201004954A TW 201004954 A TW201004954 A TW 201004954A TW 098121909 A TW098121909 A TW 098121909A TW 98121909 A TW98121909 A TW 98121909A TW 201004954 A TW201004954 A TW 201004954A
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- Taiwan
- Prior art keywords
- oxo
- solid dosage
- dosage form
- pharmaceutical formulation
- potassium
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- 239000007787 solid Substances 0.000 title claims abstract description 40
- 239000000203 mixture Substances 0.000 title claims description 146
- 238000009472 formulation Methods 0.000 title claims description 128
- YFGDMOOZPZGCFG-LEVQAPRMSA-N potassium;n-[(3r,6s)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-3h-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide;ethanolate Chemical compound [K+].CC[O-].FC1=CC=CC([C@H]2CN(CC(F)(F)F)C(=O)[C@H](NC(=O)N3CCC(CC3)N3C(NC4=NC=CC=C43)=O)CC2)=C1F YFGDMOOZPZGCFG-LEVQAPRMSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 40
- 239000004480 active ingredient Substances 0.000 claims abstract description 21
- 239000004475 Arginine Substances 0.000 claims abstract description 19
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000008180 pharmaceutical surfactant Substances 0.000 claims abstract description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 38
- 239000007909 solid dosage form Substances 0.000 claims description 35
- -1 2-oxo-2,3-dihydro-1H-imidazo[4 , 5-b]pyridin-1-yl Chemical group 0.000 claims description 31
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 26
- 239000011591 potassium Substances 0.000 claims description 26
- 229910052700 potassium Inorganic materials 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 25
- RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 claims description 25
- HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 claims description 22
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 7
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- 238000001237 Raman spectrum Methods 0.000 claims description 7
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- 239000007789 gas Substances 0.000 claims description 7
- 238000001228 spectrum Methods 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 5
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 claims description 4
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- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 3
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- QHGUCRYDKWKLMG-QMMMGPOBSA-N (R)-octopamine Chemical compound NC[C@H](O)C1=CC=C(O)C=C1 QHGUCRYDKWKLMG-QMMMGPOBSA-N 0.000 claims 1
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- ACVSHQGHCWUJFU-UHFFFAOYSA-N 2h-imidazole Chemical compound C1N=CC=N1 ACVSHQGHCWUJFU-UHFFFAOYSA-N 0.000 claims 1
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- 229930182558 Sterol Natural products 0.000 claims 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims 1
- LCGHVVVYWWMNFB-UHFFFAOYSA-N [K].NC=O Chemical compound [K].NC=O LCGHVVVYWWMNFB-UHFFFAOYSA-N 0.000 claims 1
- 125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 claims 1
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- LLLCSBYSPJHDJX-UHFFFAOYSA-M potassium;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O LLLCSBYSPJHDJX-UHFFFAOYSA-M 0.000 claims 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract description 30
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- 229950002563 telcagepant Drugs 0.000 abstract 2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Urology & Nephrology (AREA)
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- Immunology (AREA)
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- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| US13354208P | 2008-06-30 | 2008-06-30 |
Publications (1)
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| TW201004954A true TW201004954A (en) | 2010-02-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098121909A TW201004954A (en) | 2008-06-30 | 2009-06-29 | Solid dosage formulations of telcagepant potassium |
Country Status (16)
| Country | Link |
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| US (1) | US20100009967A1 (enExample) |
| EP (1) | EP2303238A1 (enExample) |
| JP (2) | JP2011526909A (enExample) |
| KR (1) | KR20110025926A (enExample) |
| CN (1) | CN102076330A (enExample) |
| AR (1) | AR072395A1 (enExample) |
| AU (1) | AU2009267145A1 (enExample) |
| CA (1) | CA2728547A1 (enExample) |
| CR (1) | CR20110038A (enExample) |
| DO (1) | DOP2010000409A (enExample) |
| IL (1) | IL209833A0 (enExample) |
| MX (1) | MX2010014524A (enExample) |
| RU (1) | RU2011103170A (enExample) |
| SV (1) | SV2010003774A (enExample) |
| TW (1) | TW201004954A (enExample) |
| WO (1) | WO2010002763A1 (enExample) |
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| JP5243548B2 (ja) * | 2007-10-25 | 2013-07-24 | プロテウス デジタル ヘルス， インコーポレイテッド | 情報システムのための流体伝達ポート |
| EP2249833B1 (en) * | 2008-02-05 | 2012-10-17 | Merck Sharp & Dohme Corp. | Prodrugs of cgrp receptor antagonist |
| WO2017001434A1 (en) * | 2015-06-29 | 2017-01-05 | Galderma Research & Development | Cgrp receptor antagonist compounds for topical treatment of skin disorders |
Family Cites Families (6)
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| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| ATE209491T1 (de) * | 1997-03-13 | 2001-12-15 | Hexal Ag | Stabilisierung von säureempfindluchen benzimidazolen unter verwendung von aminosäure/cyclodextrin kombinationen |
| US6174548B1 (en) * | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| JO2355B1 (en) * | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| AU2007238896A1 (en) * | 2006-04-10 | 2007-10-25 | Merck Sharp & Dohme Corp. | CGRP antagonist salt |
| CA2662748A1 (en) * | 2006-09-08 | 2008-03-13 | Merck & Co., Inc. | Liquid pharmaceutical formulations for oral administration of a cgrp antagonist |
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2009
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- 2009-06-29 AU AU2009267145A patent/AU2009267145A1/en not_active Abandoned
- 2009-06-29 RU RU2011103170/15A patent/RU2011103170A/ru not_active Application Discontinuation
- 2009-06-29 US US12/493,311 patent/US20100009967A1/en not_active Abandoned
- 2009-06-29 CN CN2009801252261A patent/CN102076330A/zh active Pending
- 2009-06-29 AR ARP090102404A patent/AR072395A1/es unknown
- 2009-06-29 WO PCT/US2009/049009 patent/WO2010002763A1/en not_active Ceased
- 2009-06-29 CA CA2728547A patent/CA2728547A1/en not_active Abandoned
- 2009-06-29 MX MX2010014524A patent/MX2010014524A/es not_active Application Discontinuation
- 2009-06-29 TW TW098121909A patent/TW201004954A/zh unknown
- 2009-06-29 EP EP09774214A patent/EP2303238A1/en not_active Withdrawn
- 2009-06-29 KR KR1020107029334A patent/KR20110025926A/ko not_active Withdrawn
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2010
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2011
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- 2011-07-13 JP JP2011155043A patent/JP2011246478A/ja not_active Withdrawn
Also Published As
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| MX2010014524A (es) | 2011-02-24 |
| CA2728547A1 (en) | 2010-01-07 |
| CN102076330A (zh) | 2011-05-25 |
| AU2009267145A1 (en) | 2010-01-07 |
| EP2303238A1 (en) | 2011-04-06 |
| RU2011103170A (ru) | 2012-08-10 |
| CR20110038A (es) | 2011-03-16 |
| WO2010002763A1 (en) | 2010-01-07 |
| AR072395A1 (es) | 2010-08-25 |
| JP2011526909A (ja) | 2011-10-20 |
| JP2011246478A (ja) | 2011-12-08 |
| KR20110025926A (ko) | 2011-03-14 |
| IL209833A0 (en) | 2011-02-28 |
| US20100009967A1 (en) | 2010-01-14 |
| SV2010003774A (es) | 2011-03-23 |
| DOP2010000409A (es) | 2011-02-15 |
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