AR072395A1 - Formulacion de dosificacion solida de telcagepant potasico - Google Patents

Formulacion de dosificacion solida de telcagepant potasico

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Publication number
AR072395A1
AR072395A1 ARP090102404A ARP090102404A AR072395A1 AR 072395 A1 AR072395 A1 AR 072395A1 AR P090102404 A ARP090102404 A AR P090102404A AR P090102404 A ARP090102404 A AR P090102404A AR 072395 A1 AR072395 A1 AR 072395A1
Authority
AR
Argentina
Prior art keywords
oxo
ppm
solid dosage
azepan
imidazo
Prior art date
Application number
ARP090102404A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR072395A1 publication Critical patent/AR072395A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente también se refiere a una forma amorfa de la sal potásica de telcagepant. Reivindicacion 1: Una formulacion farmacéutica de dosificacion solida que comprende (i) N-[(3R,6S)-6-(2,3-difluorofenil)-2-oxo-1-(2,2,2-trifluoroetil)azepan-3-il]-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida potásica o el hidrato o etanolato de la misma, o una forma amorfa de la misma; (ii) arginina; y (iii) un tensoactivo farmacéuticamente aceptable. Reivindicacion 12: La formulacion farmacéutica de dosificacion solida de la reivindicacion 8, en la que el etanolato de la Forma I de N-[(3R,6S)-6-(2,3-difluorofenil)-2-oxo-1-(2,2,2-trifluoroetil)azepan-3-il]-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida potásica presenta picos en el espectro de RMN de carbono-13 en estado solido de uno o más de 109,1 ppm, 55,8 ppm y 54,6 ppm. Reivindicacion 13: La formulacion farmacéutica de dosificacion solida de la reivindicacion 8, en la que el espectro Raman del etanolato de la Forma I de N-[(3R,6S)-6-(2,3-difluorofenil)-2-oxo-1-(2,2,2-trifluoroetil)azepan-3-il]-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida potásica presenta picos (cm-1) de uno o más de 646,3, 707,4, 761,5, 832,9, 1063,3, 1365,5, 1402,0, 1445,7 y 1455,3. Reivindicacion 14: La formulacion farmacéutica de dosificacion solida de la reivindicacion 10, en la que el hidrato de N-[(3R,6S)-6-(2,3-difluorofenil)-2-oxo-1-(2,2,2-trifluoroetil)azepan-3-il]-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida potásica presenta picos en el espectro de RMN de carbono-13 en estado solido de uno o más de 126,1 ppm, 54,4 ppm y 36,6 ppm. Reivindicacion 15: La formulacion farmacéutica de dosificacion solida de la reivindicacion 10, en la que el espectro Raman del hidrato de N-[(3R,6S)-6-(2,3-difluorofenil)-2-oxo-1-(2,2,2-trifluoroetil)azepan-3-il]-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida potásica presenta picos (cm-1) de uno o más de 646,8, 707,0, 753,7, 832,7, 1064,7, 1364,3, 1403,0 y 1441,0. Reivindicacion 16: La formulacion farmacéutica de dosificacion solida de la reivindicacion 11, en la que la forma amorfa de N-[(3R,6S)-6-(2,3-difluorofenil)-2-oxo-1-(2,2,2-trifluoroetil)azepan-3-il]-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida potásica presenta picos en el espectro de RMN de carbono-13 en estado solido de uno o más de 126,0 ppm, 53,7 ppm y 29,1 ppm. Reivindicacion 17: La formulacion farmacéutica de dosificacion solida de la reivindicacion 11, en la que el espectro Raman de la forma amorfa de N-[(3R,6S)-6-(2,3-difluorofenil)-2-oxo-1-(2,2,2-trifluoroetil)azepan-3-il]-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida potásica presenta picos (cm-1) de uno o más de 646,8, 706,8, 752,3, 832,4, 1063,6, 1365,2 y 1437,6.
ARP090102404A 2008-06-30 2009-06-29 Formulacion de dosificacion solida de telcagepant potasico AR072395A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13354208P 2008-06-30 2008-06-30

Publications (1)

Publication Number Publication Date
AR072395A1 true AR072395A1 (es) 2010-08-25

Family

ID=41057505

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102404A AR072395A1 (es) 2008-06-30 2009-06-29 Formulacion de dosificacion solida de telcagepant potasico

Country Status (16)

Country Link
US (1) US20100009967A1 (es)
EP (1) EP2303238A1 (es)
JP (2) JP2011526909A (es)
KR (1) KR20110025926A (es)
CN (1) CN102076330A (es)
AR (1) AR072395A1 (es)
AU (1) AU2009267145A1 (es)
CA (1) CA2728547A1 (es)
CR (1) CR20110038A (es)
DO (1) DOP2010000409A (es)
IL (1) IL209833A0 (es)
MX (1) MX2010014524A (es)
RU (1) RU2011103170A (es)
SV (1) SV2010003774A (es)
TW (1) TW201004954A (es)
WO (1) WO2010002763A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5243548B2 (ja) * 2007-10-25 2013-07-24 プロテウス デジタル ヘルス， インコーポレイテッド 情報システムのための流体伝達ポート
JP2011511792A (ja) * 2008-02-05 2011-04-14 メルク・シャープ・エンド・ドーム・コーポレイション Ｃｇｒｐ受容体アンタゴニストのプロドラッグ
WO2017001434A1 (en) * 2015-06-29 2017-01-05 Galderma Research & Development Cgrp receptor antagonist compounds for topical treatment of skin disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
WO1998040069A2 (en) * 1997-03-13 1998-09-17 Hexal Ag Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations
US6174548B1 (en) * 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
JO2355B1 (en) * 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
JP2009533440A (ja) * 2006-04-10 2009-09-17 メルク エンド カムパニー インコーポレーテッド Ｃｇｒｐ拮抗薬塩
CN101511184A (zh) * 2006-09-08 2009-08-19 默克公司 用于口服给药cgrp拮抗剂的液体药物制剂

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Publication number Publication date
DOP2010000409A (es) 2011-02-15
JP2011526909A (ja) 2011-10-20
JP2011246478A (ja) 2011-12-08
AU2009267145A1 (en) 2010-01-07
CA2728547A1 (en) 2010-01-07
US20100009967A1 (en) 2010-01-14
CR20110038A (es) 2011-03-16
WO2010002763A1 (en) 2010-01-07
CN102076330A (zh) 2011-05-25
MX2010014524A (es) 2011-02-24
SV2010003774A (es) 2011-03-23
TW201004954A (en) 2010-02-01
KR20110025926A (ko) 2011-03-14
EP2303238A1 (en) 2011-04-06
IL209833A0 (en) 2011-02-28
RU2011103170A (ru) 2012-08-10

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