TW200918069A - Quinazolinone compounds and methods of use thereof - Google Patents

Quinazolinone compounds and methods of use thereof Download PDF

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Publication number
TW200918069A
TW200918069A TW097123156A TW97123156A TW200918069A TW 200918069 A TW200918069 A TW 200918069A TW 097123156 A TW097123156 A TW 097123156A TW 97123156 A TW97123156 A TW 97123156A TW 200918069 A TW200918069 A TW 200918069A
Authority
TW
Taiwan
Prior art keywords
group
compound
propyl
acid
aryl
Prior art date
Application number
TW097123156A
Other languages
English (en)
Chinese (zh)
Inventor
Ji-Feng Liu
Syed M Ali
Mark A Ashwell
Ping Ye
You-Sheng Guan
Shi-Chung Ng
Rocio Palmer
Dan Yohannes
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of TW200918069A publication Critical patent/TW200918069A/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/90Oxygen atoms with acyclic radicals attached in position 2 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW097123156A 2007-06-22 2008-06-20 Quinazolinone compounds and methods of use thereof TW200918069A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94583807P 2007-06-22 2007-06-22

Publications (1)

Publication Number Publication Date
TW200918069A true TW200918069A (en) 2009-05-01

Family

ID=39846620

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097123156A TW200918069A (en) 2007-06-22 2008-06-20 Quinazolinone compounds and methods of use thereof

Country Status (13)

Country Link
US (1) US8232285B2 (https=)
EP (1) EP2173724B1 (https=)
JP (1) JP2010530885A (https=)
KR (1) KR20100024494A (https=)
CN (1) CN101801937A (https=)
AU (1) AU2008268613A1 (https=)
BR (1) BRPI0813355A2 (https=)
CA (1) CA2704282A1 (https=)
IL (1) IL202740A0 (https=)
MX (1) MX2009013815A (https=)
TW (1) TW200918069A (https=)
WO (1) WO2009002808A2 (https=)
ZA (1) ZA201000183B (https=)

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WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2021012208A (es) 2013-10-04 2023-01-19 Infinity Pharmaceuticals Inc Compuestos heterocíclicos y usos de los mismos.
US20150132575A1 (en) * 2013-11-14 2015-05-14 Honeywell International Inc. Luminescent fibers, articles including the same, and methods of forming the same
NZ724368A (en) 2014-03-19 2023-07-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP4585268A3 (en) 2015-09-14 2025-10-15 Twelve Therapeutics, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
EP3790878A1 (en) * 2018-05-11 2021-03-17 The United States of America, as represented by the Secretary, Department of Health and Human Services Quinoline compounds and their preparation and use as antimalarial agents
CN113354590A (zh) * 2020-03-05 2021-09-07 宁波康柏睿格医药科技有限公司 拮抗nod1/2受体信号通路的喹唑啉酮类化合物

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Also Published As

Publication number Publication date
EP2173724B1 (en) 2012-12-05
WO2009002808A3 (en) 2009-07-23
WO2009002808A2 (en) 2008-12-31
CN101801937A (zh) 2010-08-11
KR20100024494A (ko) 2010-03-05
BRPI0813355A2 (pt) 2014-12-30
ZA201000183B (en) 2011-03-30
US20090130097A1 (en) 2009-05-21
AU2008268613A1 (en) 2008-12-31
IL202740A0 (en) 2010-06-30
US8232285B2 (en) 2012-07-31
MX2009013815A (es) 2010-03-01
JP2010530885A (ja) 2010-09-16
CA2704282A1 (en) 2008-12-31
EP2173724A2 (en) 2010-04-14

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