YU9499A - Sinteza bisindolilmalimida - Google Patents

Sinteza bisindolilmalimida

Info

Publication number
YU9499A
YU9499A YU9499A YU9499A YU9499A YU 9499 A YU9499 A YU 9499A YU 9499 A YU9499 A YU 9499A YU 9499 A YU9499 A YU 9499A YU 9499 A YU9499 A YU 9499A
Authority
YU
Yugoslavia
Prior art keywords
reaction
bisindolylmalimides
optionally substituted
synthesis
indole
Prior art date
Application number
YU9499A
Other languages
English (en)
Inventor
Margaret Mary Faul
Larry Winneroski Leonard Jr.
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU9499A publication Critical patent/YU9499A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Ovaj pronalazak daje reakciju opciono supstituiranih indol-3-acetamida sa opciono supstituiranim metil indol-3-glioksil reagensom da bi se dobili moćni PKC inhibitori. Reakcija je vrlo efikasna i robusna makrokristalizacione metodologije.
YU9499A 1996-08-23 1997-08-22 Sinteza bisindolilmalimida YU9499A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2412096P 1996-08-23 1996-08-23

Publications (1)

Publication Number Publication Date
YU9499A true YU9499A (sh) 2000-03-21

Family

ID=21818966

Family Applications (1)

Application Number Title Priority Date Filing Date
YU9499A YU9499A (sh) 1996-08-23 1997-08-22 Sinteza bisindolilmalimida

Country Status (16)

Country Link
US (2) US5990319A (sh)
EP (1) EP0825190A1 (sh)
JP (1) JP2000516632A (sh)
KR (1) KR20000068323A (sh)
CN (1) CN1228082A (sh)
AU (1) AU716840B2 (sh)
BR (1) BR9711363A (sh)
CA (1) CA2263862A1 (sh)
EA (1) EA001392B1 (sh)
HU (1) HUP0003203A3 (sh)
IL (1) IL128376A0 (sh)
NO (1) NO990832L (sh)
NZ (1) NZ334030A (sh)
PL (1) PL331899A1 (sh)
WO (1) WO1998007693A1 (sh)
YU (1) YU9499A (sh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
EP2289892B1 (en) 2005-02-09 2012-08-22 ArQule, Inc. Maleimide derivatives, pharmaceutical compositions amd methods for treatment of cancer
JP5425060B2 (ja) 2007-06-22 2014-02-26 アークル インコーポレイテッド ピロリジノン、ピロリジン−２，５−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法
AU2008268613A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
US8513292B2 (en) 2007-06-22 2013-08-20 Arqule, Inc. Compositions and methods for the treatment of cancer
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
AU2013252944B2 (en) * 2012-04-23 2017-04-13 Arqule, Inc. Highly pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione and methods of preparing same
CN104496970B (zh) * 2014-12-17 2017-01-11 河南师范大学 3,4-二(3-吲哚)-2,5-二酮-3-吡咯啉亚胺类化合物及其制备方法和应用
CN104710412B (zh) * 2015-03-27 2017-03-22 河南师范大学 具有抗癌活性的3,4‑二（3‑吲哚）‑2,5‑二酮‑1‑吡咯胺硫脲类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5339712A (en) * 1993-10-25 1994-08-23 Daryoush Keyvani Hand tool having offset work elements
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
HUP0003203A3 (en) 2002-01-28
EA001392B1 (ru) 2001-02-26
CN1228082A (zh) 1999-09-08
NO990832D0 (no) 1999-02-22
IL128376A0 (en) 2000-01-31
NZ334030A (en) 2000-08-25
HUP0003203A2 (hu) 2001-06-28
AU4157097A (en) 1998-03-06
KR20000068323A (ko) 2000-11-25
AU716840B2 (en) 2000-03-09
US5948907A (en) 1999-09-07
CA2263862A1 (en) 1998-02-26
EA199900221A1 (ru) 1999-08-26
EP0825190A1 (en) 1998-02-25
NO990832L (no) 1999-04-13
BR9711363A (pt) 1999-08-17
US5990319A (en) 1999-11-23
PL331899A1 (en) 1999-08-16
JP2000516632A (ja) 2000-12-12
WO1998007693A1 (en) 1998-02-26

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