TW200904434A

TW200904434A - CCR2 receptor antagonists and uses thereof

CCR2 receptor antagonists and uses thereof Download PDF

Info

Publication number: TW200904434A
Authority: TW; Taiwan
Prior art keywords: group; alkyl; phenyl; amino; doc
Prior art date: 2007-05-31

Application number

TW097120340A

Other languages

English (en)

Chinese (zh)

Inventor

Heiner Ebel

Stefan Peters

Silke Hobbie

Original Assignee

Boehringer Ingelheim Int

Priority date

2007-05-31

Filing date

2008-05-30

Publication date

2009-02-01

2008-05-30 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2009-02-01 Publication of TW200904434A publication Critical patent/TW200904434A/zh

Links

102000004497 CCR2 Receptors Human genes 0.000 title abstract description 15
108010017312 CCR2 Receptors Proteins 0.000 title abstract description 15
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 55
201000010099 disease Diseases 0.000 claims abstract description 49
239000003814 drug Substances 0.000 claims abstract description 11
208000006673 asthma Diseases 0.000 claims abstract description 9
-1 -benzyl Chemical group 0.000 claims description 266
239000002253 acid Substances 0.000 claims description 153
125000000217 alkyl group Chemical group 0.000 claims description 118
150000003839 salts Chemical class 0.000 claims description 116
239000000203 mixture Substances 0.000 claims description 100
150000001875 compounds Chemical class 0.000 claims description 94
230000003287 optical effect Effects 0.000 claims description 83
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 57
125000003118 aryl group Chemical group 0.000 claims description 55
239000012453 solvate Substances 0.000 claims description 52
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 43
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 42
230000015572 biosynthetic process Effects 0.000 claims description 39
125000005842 heteroatom Chemical group 0.000 claims description 38
229910052736 halogen Inorganic materials 0.000 claims description 33
150000002367 halogens Chemical class 0.000 claims description 25
150000004677 hydrates Chemical class 0.000 claims description 23
239000003795 chemical substances by application Substances 0.000 claims description 22
125000001424 substituent group Chemical group 0.000 claims description 21
229920006395 saturated elastomer Polymers 0.000 claims description 20
125000002947 alkylene group Chemical group 0.000 claims description 17
125000000753 cycloalkyl group Chemical group 0.000 claims description 17
229910052757 nitrogen Inorganic materials 0.000 claims description 17
125000004433 nitrogen atom Chemical group N* 0.000 claims description 16
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241001465754 Metazoa Species 0.000 claims description 15
125000004429 atom Chemical group 0.000 claims description 15
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238000011282 treatment Methods 0.000 claims description 14
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 13
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