TW200745079A - Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor - Google Patents

Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor

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Publication number
TW200745079A
TW200745079A TW095132161A TW95132161A TW200745079A TW 200745079 A TW200745079 A TW 200745079A TW 095132161 A TW095132161 A TW 095132161A TW 95132161 A TW95132161 A TW 95132161A TW 200745079 A TW200745079 A TW 200745079A
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TW
Taiwan
Prior art keywords
methyl
polymorphs
methods
benzonitrile
dioxo
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Application number
TW095132161A
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English (en)
Chinese (zh)
Inventor
Keith Lorimer
Mark Andres
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Takeda Pharmaceuticals Co
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Publication of TW200745079A publication Critical patent/TW200745079A/zh

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
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  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Communicable Diseases (AREA)
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TW095132161A 2005-09-16 2006-08-31 Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor TW200745079A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71813305P 2005-09-16 2005-09-16

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TW200745079A true TW200745079A (en) 2007-12-16

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TW095132161A TW200745079A (en) 2005-09-16 2006-08-31 Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor

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Country Link
US (1) US20070066635A1 (enExample)
EP (1) EP1934198B1 (enExample)
JP (1) JP5124464B2 (enExample)
KR (1) KR20080056183A (enExample)
CN (1) CN101360735A (enExample)
AR (1) AR056518A1 (enExample)
AT (1) ATE518851T1 (enExample)
AU (1) AU2006292637A1 (enExample)
BR (1) BRPI0616215A2 (enExample)
CA (1) CA2622698A1 (enExample)
CR (1) CR9881A (enExample)
EA (1) EA015359B1 (enExample)
GE (1) GEP20115171B (enExample)
IL (1) IL190170A0 (enExample)
MA (1) MA29800B1 (enExample)
NO (1) NO20081581L (enExample)
NZ (1) NZ566798A (enExample)
PE (1) PE20070766A1 (enExample)
TW (1) TW200745079A (enExample)
WO (1) WO2007035372A2 (enExample)
ZA (1) ZA200802856B (enExample)

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CN104151291B (zh) * 2014-08-08 2016-01-20 江苏德源药业股份有限公司 一种苯甲酸阿格列汀多晶型晶体的制备方法
CN104803976A (zh) * 2015-05-18 2015-07-29 苏州亚宝药物研发有限公司 一种苯甲酸阿格列汀原料药的工业生产方法
CN107810005B (zh) * 2015-06-17 2021-04-20 赫克萨尔股份公司 阿格列汀制剂
CN106349215B (zh) * 2015-07-15 2022-02-08 深圳信立泰药业股份有限公司 一种化合物a苯甲酸盐的无定形及其制备方法和含有该无定形的药物组合物
CN105820153A (zh) * 2016-03-15 2016-08-03 威海迪素制药有限公司 一种苯甲酸阿格列汀新晶型
CN107573321A (zh) * 2017-09-04 2018-01-12 东南大学 4位取代的苯甲酸与阿格列汀形成的盐晶及制备方法
TR202022144A1 (tr) 2020-12-29 2022-07-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Alogli̇pti̇n i̇çeren farmasöti̇k kompozi̇syonlar
TR202022612A2 (tr) * 2020-12-31 2022-07-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Alogli̇pti̇ni̇n farmasöti̇k kapsül kompozi̇syonlari

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ATE518851T1 (de) 2011-08-15
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