TW200736232A - Pyrimidine derivatives - Google Patents
Pyrimidine derivativesInfo
- Publication number
- TW200736232A TW200736232A TW096102121A TW96102121A TW200736232A TW 200736232 A TW200736232 A TW 200736232A TW 096102121 A TW096102121 A TW 096102121A TW 96102121 A TW96102121 A TW 96102121A TW 200736232 A TW200736232 A TW 200736232A
- Authority
- TW
- Taiwan
- Prior art keywords
- pyrimidine derivatives
- compounds
- ephb4
- epha2
- tumours
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76238706P | 2006-01-26 | 2006-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200736232A true TW200736232A (en) | 2007-10-01 |
Family
ID=38229185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW096102121A TW200736232A (en) | 2006-01-26 | 2007-01-19 | Pyrimidine derivatives |
Country Status (16)
Country | Link |
---|---|
US (1) | US20110046108A1 (zh) |
EP (1) | EP1981856A2 (zh) |
JP (1) | JP2009524632A (zh) |
KR (1) | KR20080089504A (zh) |
CN (1) | CN101374818A (zh) |
AR (1) | AR059218A1 (zh) |
AU (1) | AU2007209126B2 (zh) |
BR (1) | BRPI0707284A2 (zh) |
CA (1) | CA2640375A1 (zh) |
IL (1) | IL192610A0 (zh) |
NO (1) | NO20083059L (zh) |
NZ (1) | NZ569763A (zh) |
TW (1) | TW200736232A (zh) |
UY (1) | UY30107A1 (zh) |
WO (1) | WO2007085833A2 (zh) |
ZA (1) | ZA200806153B (zh) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
DK1534286T3 (da) | 2002-07-29 | 2010-04-26 | Rigel Pharmaceuticals Inc | Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser |
CN1849318B (zh) | 2003-07-30 | 2011-10-12 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物预防和治疗自体免疫疾病的方法 |
CN101115761B (zh) | 2005-01-19 | 2012-07-18 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物的前药及其应用 |
PL1984357T3 (pl) | 2006-02-17 | 2014-03-31 | Rigel Pharmaceuticals Inc | Związki 2,4-pirymidynodiaminy do leczenia lub zapobiegania chorób autoimmunologicznych |
ATE497496T1 (de) * | 2006-10-19 | 2011-02-15 | Rigel Pharmaceuticals Inc | 2,4-pyridimediamon-derivate als hemmer von jak- kinasen zur behandlung von autoimmunerkrankungen |
TWI432427B (zh) | 2006-10-23 | 2014-04-01 | Cephalon Inc | 作為ALK及c-MET抑制劑之2,4-二胺基嘧啶之融合雙環衍生物 |
AU2008244026A1 (en) * | 2007-04-27 | 2008-11-06 | Astrazeneca Ab | N' - (phenyl) -N- (morpholin-4-yl-pyridin-2-yl) -pyrimidine-2, 4-diamine derivatives as EphB4 kinase inhibitors for the treatment of proliferative conditions |
BRPI0814821A2 (pt) | 2007-07-16 | 2015-02-03 | Astrazeneca Ab | Composto, composição farmacêutica, e, processo para preparar um composto |
WO2009010794A1 (en) * | 2007-07-19 | 2009-01-22 | Astrazeneca Ab | 2,4-diamino-pyrimidine derivatives |
SI2178870T1 (sl) * | 2007-08-17 | 2018-11-30 | Lg Chem, Ltd. | Indolne in indazolne spojine kot inhibitor celične nekroze |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
ES2645689T3 (es) | 2008-05-21 | 2017-12-07 | Ariad Pharmaceuticals, Inc. | Derivados de fósforo como inhibidores de quinasas |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
US8338439B2 (en) * | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
RU2536584C2 (ru) | 2008-06-27 | 2014-12-27 | Авила Терапьютикс, Инк. | Гетероарильные соединения и их применение |
CN101659659B (zh) * | 2008-08-29 | 2013-01-02 | 和记黄埔医药(上海)有限公司 | 嘧啶衍生物及其医药用途 |
WO2010072155A1 (zh) * | 2008-12-26 | 2010-07-01 | 复旦大学 | 一种嘧啶类衍生物及其制备方法和用途 |
KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Egfr 억제제 및 질환 치료방법 |
IN2012DN02534A (zh) | 2009-09-16 | 2015-08-28 | Avila Therapeutics Inc | |
BR112012015721A2 (pt) | 2009-12-30 | 2017-09-26 | Avila Therapeutics Inc | modificação covalente de proteínas dirigida por ligante |
EP2536696A1 (en) | 2010-02-18 | 2012-12-26 | Concert Pharmaceuticals Inc. | Pyrimidine derivatives |
US20130023532A1 (en) * | 2010-03-26 | 2013-01-24 | Casillas Linda N | Indazolyl-pyrimidines as kinase inhibitors |
JP5607241B2 (ja) | 2010-05-21 | 2014-10-15 | ケミリア・エービー | 新規ピリミジン誘導体 |
EP2395001A1 (en) | 2010-05-21 | 2011-12-14 | Chemilia AB | Novel pyrimidine derivatives |
US8563568B2 (en) | 2010-08-10 | 2013-10-22 | Celgene Avilomics Research, Inc. | Besylate salt of a BTK inhibitor |
CN103269704B (zh) | 2010-11-01 | 2018-07-06 | 西建卡尔有限责任公司 | 杂环化合物和其用途 |
JP5956999B2 (ja) | 2010-11-01 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | ヘテロアリール化合物およびその使用 |
ES2665013T3 (es) | 2010-11-10 | 2018-04-24 | Celgene Car Llc | Inhibidores de EGFR selectivos de mutante y usos de los mismos |
MX2013010898A (es) | 2011-03-24 | 2013-12-06 | Chemilia Ab | Novedoso derivados de la pirimidina. |
EP2502924A1 (en) | 2011-03-24 | 2012-09-26 | Chemilia AB | Novel pyrimidine derivatives |
KR101884010B1 (ko) | 2011-05-04 | 2018-07-31 | 어리어드 파마슈티칼스, 인코포레이티드 | Egfr-유도된 암의 세포 증식을 억제하는 화합물 |
WO2013054351A1 (en) * | 2011-08-08 | 2013-04-18 | Cadila Healthcare Limited | Heterocyclic compounds |
EP2770830A4 (en) | 2011-10-28 | 2015-05-27 | Celgene Avilomics Res Inc | METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE) |
RS57901B1 (sr) | 2012-03-15 | 2019-01-31 | Celgene Car Llc | Soli inhibitora kinaze receptora epidermalnog faktora rasta |
MX356753B (es) | 2012-03-15 | 2018-06-12 | Celgene Avilomics Res Inc | Formas solidas de un inhibidor de cinasa del receptor del factor de crecimiento epidermico. |
JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
EP2711364A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
EP2711365A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
WO2014071832A1 (en) * | 2012-11-06 | 2014-05-15 | Shanghai Fochon Pharmaceutical Co Ltd | Alk kinase inhibitors |
WO2014100748A1 (en) | 2012-12-21 | 2014-06-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
EA201591051A1 (ru) | 2013-02-08 | 2016-06-30 | Селджен Авиломикс Рисерч, Инк. | Ингибиторы erk и варианты их применения |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
ES2741785T3 (es) | 2014-08-13 | 2020-02-12 | Celgene Car Llc | Formas y composiciones de un inhibidor de ERK |
ES2953512T3 (es) * | 2016-04-15 | 2023-11-14 | Epizyme Inc | Compuestos de arilo o heteroarilo sustituidos con amina como inhibidores de EHMT1 y EHMT2 |
WO2018195450A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
NZ761156A (en) | 2017-07-28 | 2024-01-26 | Yuhan Corp | Improved process for preparing aminopyrimidine derivatives |
CN111234067B (zh) * | 2018-11-29 | 2021-08-03 | 中国石油化工股份有限公司 | 用于烯烃聚合的固体催化剂组分和催化剂及其应用 |
CN113801108B (zh) * | 2020-06-16 | 2024-02-27 | 中国药科大学 | 蛋白激酶抑制剂及其衍生物,制备方法、药物组合物和应用 |
US20230373960A1 (en) * | 2020-09-22 | 2023-11-23 | Beigene, Ltd. | Indoline compounds and derivatives as egfr inhibitors |
WO2022068849A1 (en) * | 2020-09-30 | 2022-04-07 | Beigene, Ltd. | Bifunctional compounds for degradation of egfr and related methods of use |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1107957B1 (en) * | 1998-08-29 | 2006-10-18 | AstraZeneca AB | Pyrimidine compounds |
AU3704101A (en) * | 2000-02-17 | 2001-08-27 | Amgen Inc | Kinase inhibitors |
IL156306A0 (en) * | 2000-12-21 | 2004-01-04 | Glaxo Group Ltd | Pyrimidineamines as angiogenesis modulators |
US6939874B2 (en) * | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
AU2003231231A1 (en) * | 2002-05-06 | 2003-11-11 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
WO2004074244A2 (en) * | 2003-02-20 | 2004-09-02 | Smithkline Beecham Corporation | Pyrimidine compounds |
SG145749A1 (en) * | 2003-08-15 | 2008-09-29 | Novartis Ag | 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
WO2006129100A1 (en) * | 2005-06-03 | 2006-12-07 | Glaxo Group Limited | Novel compounds |
-
2007
- 2007-01-19 TW TW096102121A patent/TW200736232A/zh unknown
- 2007-01-24 UY UY30107A patent/UY30107A1/es not_active Application Discontinuation
- 2007-01-25 CA CA002640375A patent/CA2640375A1/en not_active Abandoned
- 2007-01-25 AU AU2007209126A patent/AU2007209126B2/en not_active Ceased
- 2007-01-25 BR BRPI0707284-8A patent/BRPI0707284A2/pt not_active IP Right Cessation
- 2007-01-25 JP JP2008551870A patent/JP2009524632A/ja active Pending
- 2007-01-25 CN CNA2007800034909A patent/CN101374818A/zh active Pending
- 2007-01-25 KR KR1020087020606A patent/KR20080089504A/ko not_active Application Discontinuation
- 2007-01-25 NZ NZ569763A patent/NZ569763A/en not_active IP Right Cessation
- 2007-01-25 WO PCT/GB2007/000251 patent/WO2007085833A2/en active Application Filing
- 2007-01-25 US US12/161,766 patent/US20110046108A1/en not_active Abandoned
- 2007-01-25 EP EP07700405A patent/EP1981856A2/en not_active Withdrawn
- 2007-01-26 AR ARP070100358A patent/AR059218A1/es not_active Application Discontinuation
-
2008
- 2008-07-03 IL IL192610A patent/IL192610A0/en unknown
- 2008-07-09 NO NO20083059A patent/NO20083059L/no not_active Application Discontinuation
- 2008-07-15 ZA ZA200806153A patent/ZA200806153B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0707284A2 (pt) | 2011-04-26 |
UY30107A1 (es) | 2007-08-31 |
WO2007085833A2 (en) | 2007-08-02 |
JP2009524632A (ja) | 2009-07-02 |
IL192610A0 (en) | 2009-08-03 |
CN101374818A (zh) | 2009-02-25 |
NZ569763A (en) | 2012-06-29 |
CA2640375A1 (en) | 2007-08-02 |
WO2007085833A3 (en) | 2007-09-27 |
ZA200806153B (en) | 2009-07-29 |
AU2007209126A1 (en) | 2007-08-02 |
EP1981856A2 (en) | 2008-10-22 |
KR20080089504A (ko) | 2008-10-06 |
AR059218A1 (es) | 2008-03-19 |
NO20083059L (no) | 2008-10-22 |
AU2007209126B2 (en) | 2012-01-19 |
US20110046108A1 (en) | 2011-02-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW200736232A (en) | Pyrimidine derivatives | |
SG170069A1 (en) | Quinoline derivatives | |
MX2012007273A (es) | Pteridinonas como inhibidores de la quinasa tipo polo. | |
TW200800944A (en) | Benzamide compounds | |
TW200602328A (en) | Quinazoline derivatives | |
TW200621762A (en) | Novel compounds | |
GB0612423D0 (en) | Therapeutic agents | |
MX2009000884A (es) | Derivados de piridizinona. | |
TW200730502A (en) | Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents | |
MX2009002010A (es) | Derivados de heteroarilo como inhibidores de la proteina cinasa. | |
IN2012DN01233A (zh) | ||
TW200612936A (en) | Indole derivatives | |
TW200639156A (en) | New compounds | |
MX2010009022A (es) | Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso. | |
TW200806300A (en) | New therapeutic combinations for the treatment of depression | |
TW200734334A (en) | Treatment of substance abuse | |
ECSP099767A (es) | Derivados de n' - (fenil) -n- (morfolin-4-il-piridin-2-il) -pirimidina-2, 4-diamina como inhibidores de quinasas ephb4 para el tratamiento de afecciones proliferativas | |
WO2012168885A9 (en) | Bisacodyl and its analogues as drugs for use in the treatment of cancer | |
TW200719899A (en) | Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents | |
MX2008012093A (es) | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de trastornos psicoticos. | |
TW200745085A (en) | Quinoline derivatives | |
IL191670A0 (en) | Compounds for the inhibition of apoptosis | |
TW200637824A (en) | Benzamide derivatives | |
TW200736220A (en) | Pyridylsulfonamide derivatives, their manufacture and use as pharmaceutical agents | |
TW200720239A (en) | Styrylsulfonamides, their manufacture and use as pharmaceutical agents |