TW200716644A - Aspartyl protease inhibitors - Google Patents
Aspartyl protease inhibitorsInfo
- Publication number
- TW200716644A TW200716644A TW095121028A TW95121028A TW200716644A TW 200716644 A TW200716644 A TW 200716644A TW 095121028 A TW095121028 A TW 095121028A TW 95121028 A TW95121028 A TW 95121028A TW 200716644 A TW200716644 A TW 200716644A
- Authority
- TW
- Taiwan
- Prior art keywords
- compounds
- aspartyl protease
- formula
- disclosed
- protease inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69032605P | 2005-06-14 | 2005-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200716644A true TW200716644A (en) | 2007-05-01 |
Family
ID=37074234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095121028A TW200716644A (en) | 2005-06-14 | 2006-06-13 | Aspartyl protease inhibitors |
Country Status (18)
Country | Link |
---|---|
US (1) | US7759354B2 (zh) |
EP (1) | EP1896477B1 (zh) |
JP (1) | JP2008543840A (zh) |
KR (1) | KR20080031189A (zh) |
CN (1) | CN101198609A (zh) |
AR (1) | AR054620A1 (zh) |
AT (1) | ATE482214T1 (zh) |
AU (1) | AU2006259675A1 (zh) |
CA (1) | CA2610812A1 (zh) |
DE (1) | DE602006017073D1 (zh) |
ES (1) | ES2350854T3 (zh) |
HK (1) | HK1109151A1 (zh) |
IL (1) | IL187623A0 (zh) |
MX (1) | MX2007016175A (zh) |
PE (1) | PE20070018A1 (zh) |
TW (1) | TW200716644A (zh) |
WO (1) | WO2006138192A1 (zh) |
ZA (1) | ZA200710337B (zh) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
CA2610812A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
CA2609582A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
EP2612854B1 (en) | 2005-10-25 | 2015-04-29 | Shionogi&Co., Ltd. | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors |
JP2009539983A (ja) | 2006-06-12 | 2009-11-19 | シェーリング コーポレイション | 複素環式アスパルチルプロテアーゼ阻害薬 |
US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
MX2009006227A (es) * | 2006-12-12 | 2009-06-22 | Schering Corp | Inhibidores de aspartil proteasa que contienen un sistema de anillo triciclico. |
TW200902526A (en) | 2007-04-24 | 2009-01-16 | Shionogi & Amp Co Ltd | Aminodihydrothiazin derivative substituted with a cyclic group |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
CN101848897A (zh) | 2007-09-06 | 2010-09-29 | 先灵公司 | γ分泌酶调节剂 |
WO2009061699A1 (en) | 2007-11-05 | 2009-05-14 | Schering Corporation | Gamma secretase modulators |
EP2227471A1 (en) | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
CA2721738A1 (en) | 2008-04-22 | 2009-10-29 | Schering Corporation | Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use |
NZ589590A (en) | 2008-06-13 | 2012-05-25 | Shionogi & Co | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
WO2010021680A2 (en) * | 2008-08-19 | 2010-02-25 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
JP5503663B2 (ja) | 2008-11-13 | 2014-05-28 | メルク・シャープ・アンド・ドーム・コーポレーション | ガンマセクレターゼモジュレータ |
AR074702A1 (es) | 2008-12-22 | 2011-02-02 | Schering Corp | Moduladores de gamma secretasa y composiciones farmaceuticas que los contienen |
WO2010075203A1 (en) | 2008-12-22 | 2010-07-01 | Schering Corporation | Gamma secretase modulators |
KR20120001756A (ko) | 2009-03-13 | 2012-01-04 | 비타이 파마슈티컬즈, 인코포레이티드 | 베타세크리타아제 저해제 |
EP2443118A1 (en) | 2009-06-16 | 2012-04-25 | Schering Corporation | Gamma secretase modulators |
EP2443121A2 (en) | 2009-06-16 | 2012-04-25 | Schering Corporation | Gamma secretase modulators |
EP2443119A1 (en) | 2009-06-16 | 2012-04-25 | Schering Corporation | Gamma secretase modulators |
US8563543B2 (en) | 2009-10-08 | 2013-10-22 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
WO2011044185A2 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
WO2011044184A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
US8999980B2 (en) | 2009-12-11 | 2015-04-07 | Shionogi & Co., Ltd. | Oxazine derivatives |
US8889703B2 (en) | 2010-02-24 | 2014-11-18 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
EP2634186A4 (en) | 2010-10-29 | 2014-03-26 | Shionogi & Co | naphthyridine |
WO2012138590A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
EP2694489B1 (en) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
BR112014004181A2 (pt) | 2011-08-22 | 2017-06-13 | Merck Sharp & Dohme | composto, composição farmacêutica, e, método de tratamento, prevenção, e / ou retardo do início de uma doença ou patologia |
TWI557112B (zh) | 2012-03-05 | 2016-11-11 | 百靈佳殷格翰國際股份有限公司 | β-分泌酶抑制劑 |
JP6482458B2 (ja) | 2012-03-19 | 2019-03-13 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | App特異性のbace(asbi)およびその使用 |
TW201422592A (zh) | 2012-08-27 | 2014-06-16 | Boehringer Ingelheim Int | β-分泌酶抑制劑 |
WO2014052398A1 (en) | 2012-09-28 | 2014-04-03 | Vitae Pharmaceuticals, Inc. | Inhibitor of beta-secretase |
EP2908825B1 (en) | 2012-10-17 | 2018-04-18 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
EP2908824B1 (en) | 2012-10-17 | 2018-05-02 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
US20140371283A1 (en) | 2013-02-12 | 2014-12-18 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
ES2612982T3 (es) | 2013-02-25 | 2017-05-19 | Merck Patent Gmbh | Derivados de 2-amino-3,4-dihidroquinazolina y su aplicación como inhibidores de la catepsina D |
WO2017142825A2 (en) | 2016-02-18 | 2017-08-24 | Merck Sharp & Dohme Corp. | N3-substituted iminopyrimidinones as antimalarial agents |
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JPS60173546A (ja) * | 1984-02-20 | 1985-09-06 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料の現像処理方法 |
IL102764A0 (en) * | 1991-08-16 | 1993-01-31 | Merck & Co Inc | Quinazoline derivatives,and pharmaceutical compositions containing them |
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WO1998002436A1 (en) * | 1996-07-15 | 1998-01-22 | Bristol-Myers Squibb Company | Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase |
FR2756282B1 (fr) * | 1996-11-22 | 1998-12-31 | Elf Aquitaine | Procede de synthese d'esters de l'acide mercapto-3-propionique |
EP1054871A2 (en) * | 1998-04-01 | 2000-11-29 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
EP1340760A1 (en) * | 2002-02-28 | 2003-09-03 | Sanofi-Synthelabo | Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives |
EP1295885A1 (en) | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives |
EP1340761A1 (en) | 2002-02-28 | 2003-09-03 | Sanofi-Synthelabo | Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives |
DK1430056T3 (da) * | 2001-09-21 | 2006-02-27 | Sanofi Aventis | Substituerede 2-pyrimidinyl - 6,7,8,9-tetrahydropyrimido-[1,2-a]pyrimidin-4-on- og 7-pyrimidinyl-2,3-dihydroimidazo [1,2-a] pyrimidin-5 (1H) onderivater mod neurodegenerative lidelser |
JP4472700B2 (ja) * | 2003-08-08 | 2010-06-02 | シェーリング コーポレイション | 複素環置換基を有する環状アミンbase−1阻害剤 |
AR045218A1 (es) | 2003-08-08 | 2005-10-19 | Schering Corp | Aminas ciclicas inhibidoras de bace-1 que poseen una benzamida sustituyente; composiciones farmaceuticas que las contienen y su uso en la fabricacion de medicamentos para tratar enfermedades cognitivas o neurodegenerativas. |
WO2005053811A2 (en) * | 2003-11-21 | 2005-06-16 | Johns Hopkins University | Biomolecule partition motifs and uses thereof |
US7700603B2 (en) * | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
EP2153832B1 (en) | 2003-12-15 | 2016-03-09 | Merck Sharp & Dohme Corp. | Heterocyclic aspartyl protease inhibitors |
JPWO2005073365A1 (ja) | 2004-01-29 | 2007-09-13 | 株式会社 ジャパン・ティッシュ・エンジニアリング | 移植用細胞の処理方法、細胞懸濁液、移植用補綴物、および損傷部位の治療方法 |
DE102004007076A1 (de) * | 2004-02-13 | 2005-08-25 | Bayer Cropscience Ag | Imidazolopyrimidine |
CA2578600A1 (en) * | 2004-06-16 | 2006-01-26 | Wyeth | Diphenylimidazopyrimidine and -imidazole amines as inhibitors of b-secretase |
WO2006009653A1 (en) * | 2004-06-16 | 2006-01-26 | Wyeth | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
ES2355733T3 (es) * | 2004-07-22 | 2011-03-30 | Schering Corporation | Inhibidores de amida beta-secretasa sustituidos. |
JP2008508289A (ja) * | 2004-07-28 | 2008-03-21 | シェーリング コーポレイション | 大環状βセクレターゼ阻害剤 |
WO2006044497A2 (en) | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer’s disease |
WO2006041404A1 (en) | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Substituted amino-compounds and uses thereof |
US7534807B2 (en) * | 2005-02-18 | 2009-05-19 | North Carolina State University | De novo synthesis of bacteriochlorins |
WO2006138217A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
US8110682B2 (en) * | 2005-06-14 | 2012-02-07 | Schering Corporation | Preparation and use of compounds as aspartyl protease inhibitors |
CA2610812A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
KR20080028881A (ko) * | 2005-06-14 | 2008-04-02 | 쉐링 코포레이션 | 헤테로사이클릭 아스파르틸 프로테아제 억제제, 이의제조방법 및 용도 |
PE20070078A1 (es) | 2005-06-14 | 2007-03-08 | Schering Corp | Compuestos heterociclicos macrociclicos como inhibidores de aspartil proteasa |
CA2609582A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
EP1896406A2 (en) | 2005-06-14 | 2008-03-12 | Shering Corporation | The preparation and use of compounds as protease inhibitors |
EP1928237A4 (en) * | 2005-09-02 | 2011-03-09 | Abbott Lab | NEW HETEROCYCLES BASED ON IMIDAZO |
AR057983A1 (es) * | 2005-10-27 | 2008-01-09 | Schering Corp | Inhibidores hterociclicos de aspartil proteasas |
CN101351460A (zh) * | 2005-10-31 | 2009-01-21 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
MX2008009354A (es) | 2006-01-18 | 2008-09-30 | Schering Corp | Moduladores de receptores cannabinoides. |
JP2009539983A (ja) * | 2006-06-12 | 2009-11-19 | シェーリング コーポレイション | 複素環式アスパルチルプロテアーゼ阻害薬 |
EP2086644A2 (en) | 2006-11-17 | 2009-08-12 | Schering Corporation | Combination of an inhibitor of dna polymerase-alpha and an inhibitor of a checkpoint kinase for proliferative disorders |
US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
MX2009006227A (es) | 2006-12-12 | 2009-06-22 | Schering Corp | Inhibidores de aspartil proteasa que contienen un sistema de anillo triciclico. |
-
2006
- 2006-06-12 CA CA002610812A patent/CA2610812A1/en not_active Abandoned
- 2006-06-12 ES ES06784753T patent/ES2350854T3/es active Active
- 2006-06-12 MX MX2007016175A patent/MX2007016175A/es unknown
- 2006-06-12 WO PCT/US2006/022698 patent/WO2006138192A1/en active Application Filing
- 2006-06-12 AU AU2006259675A patent/AU2006259675A1/en not_active Abandoned
- 2006-06-12 US US11/451,074 patent/US7759354B2/en active Active
- 2006-06-12 EP EP06784753A patent/EP1896477B1/en active Active
- 2006-06-12 DE DE602006017073T patent/DE602006017073D1/de active Active
- 2006-06-12 KR KR1020077029729A patent/KR20080031189A/ko not_active Application Discontinuation
- 2006-06-12 JP JP2008516963A patent/JP2008543840A/ja active Pending
- 2006-06-12 AR ARP060102466A patent/AR054620A1/es not_active Application Discontinuation
- 2006-06-12 CN CNA2006800212013A patent/CN101198609A/zh active Pending
- 2006-06-12 AT AT06784753T patent/ATE482214T1/de not_active IP Right Cessation
- 2006-06-13 TW TW095121028A patent/TW200716644A/zh unknown
- 2006-06-13 PE PE2006000661A patent/PE20070018A1/es not_active Application Discontinuation
-
2007
- 2007-11-25 IL IL187623A patent/IL187623A0/en unknown
- 2007-11-28 ZA ZA200710337A patent/ZA200710337B/xx unknown
-
2008
- 2008-03-18 HK HK08103079.0A patent/HK1109151A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE482214T1 (de) | 2010-10-15 |
EP1896477B1 (en) | 2010-09-22 |
KR20080031189A (ko) | 2008-04-08 |
AR054620A1 (es) | 2007-07-04 |
AU2006259675A1 (en) | 2006-12-28 |
US7759354B2 (en) | 2010-07-20 |
WO2006138192A1 (en) | 2006-12-28 |
JP2008543840A (ja) | 2008-12-04 |
DE602006017073D1 (en) | 2010-11-04 |
ZA200710337B (en) | 2008-12-31 |
EP1896477A1 (en) | 2008-03-12 |
HK1109151A1 (en) | 2008-05-30 |
MX2007016175A (es) | 2008-03-07 |
US20060281730A1 (en) | 2006-12-14 |
ES2350854T3 (es) | 2011-01-27 |
PE20070018A1 (es) | 2007-03-08 |
CA2610812A1 (en) | 2006-12-28 |
CN101198609A (zh) | 2008-06-11 |
IL187623A0 (en) | 2008-03-20 |
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