TW200633716A - Compositions and methods for stabilizing active pharmaceutical ingredients - Google Patents

Compositions and methods for stabilizing active pharmaceutical ingredients

Info

Publication number
TW200633716A
TW200633716A TW094143885A TW94143885A TW200633716A TW 200633716 A TW200633716 A TW 200633716A TW 094143885 A TW094143885 A TW 094143885A TW 94143885 A TW94143885 A TW 94143885A TW 200633716 A TW200633716 A TW 200633716A
Authority
TW
Taiwan
Prior art keywords
compositions
methods
active pharmaceutical
pharmaceutical ingredients
stabilizing active
Prior art date
Application number
TW094143885A
Other languages
English (en)
Inventor
William Michael Nichols
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of TW200633716A publication Critical patent/TW200633716A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW094143885A 2004-12-13 2005-12-12 Compositions and methods for stabilizing active pharmaceutical ingredients TW200633716A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63545004P 2004-12-13 2004-12-13

Publications (1)

Publication Number Publication Date
TW200633716A true TW200633716A (en) 2006-10-01

Family

ID=36129953

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094143885A TW200633716A (en) 2004-12-13 2005-12-12 Compositions and methods for stabilizing active pharmaceutical ingredients

Country Status (15)

Country Link
US (1) US20060127473A1 (zh)
EP (1) EP1874275A1 (zh)
JP (1) JP2008523044A (zh)
KR (1) KR20080013847A (zh)
CN (1) CN101262852A (zh)
AR (1) AR052153A1 (zh)
AU (1) AU2005315291A1 (zh)
BR (1) BRPI0518553A2 (zh)
CA (1) CA2590834A1 (zh)
MX (1) MX2007007069A (zh)
NZ (1) NZ555909A (zh)
RU (1) RU2391115C2 (zh)
TW (1) TW200633716A (zh)
WO (1) WO2006064327A1 (zh)
ZA (1) ZA200705750B (zh)

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NZ588134A (en) * 2005-06-17 2010-11-26 Aft Pharmaceuticals Ltd Novel pharmaceutical for use in a method for treatment of upper respiratory mucosal congestion
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
US8940796B2 (en) 2006-02-21 2015-01-27 Wyeth Llc Phenylephrine liquid formulations
TWI411451B (zh) 2006-06-01 2013-10-11 Msd Consumer Care Inc 用於結腸吸收之脫羥腎上腺素醫藥調配物及組合物
EP2029114B1 (en) * 2006-06-01 2014-09-24 Merck Sharp & Dohme Corp. Pharmaceutical compositions for sustained release of phenylephrine
AU2007254819A1 (en) * 2006-06-01 2007-12-13 Schering Corporation Phenylphrine pulsed release formulations and pharmaceutical compositions
NZ573174A (en) * 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
US9005652B2 (en) 2006-07-25 2015-04-14 Wyeth Chewable tablet containing phenylephrine
US20090068262A1 (en) * 2007-04-04 2009-03-12 Ilan Zalit Rapid dissolution of combination products
WO2008150493A1 (en) * 2007-06-01 2008-12-11 Schering-Plough Healthcare Products, Inc. Pharmaceutical composition comprising a substrate and a coating containing an active ingredient and polyvinylalcohol
US8323695B2 (en) * 2007-08-13 2012-12-04 Mcneil-Ppc, Inc. Method for stabilizing phenylephrine
US9078824B2 (en) * 2007-09-24 2015-07-14 The Procter & Gamble Company Composition and method of stabilized sensitive ingredient
PE20091084A1 (es) * 2007-12-07 2009-07-23 Schering Plough Healthcare Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal
US20090214665A1 (en) * 2008-02-26 2009-08-27 Lai Felix S Controlled Release Muscarinic Receptor Antagonist Formulation
US8491930B2 (en) * 2008-04-23 2013-07-23 Farmasierra Manufacturing, S.L. Pharmaceutical formulation containing ibuprofen and codeine
US20110189274A1 (en) * 2008-10-06 2011-08-04 Swati Mukherjee Stable Pharmaceutical Compositions Of Montelukast Or Its Salts Or Solvates Or Hydrates
US10130627B2 (en) * 2008-12-19 2018-11-20 GlaxoSmithKine Consumer Healthcare S.A. Phenylephrine formulations with improved stability
EP2379057B1 (en) 2008-12-19 2013-07-17 Novartis AG Phenylephrine formulations with improved stability
US8603527B2 (en) * 2010-10-25 2013-12-10 Signal Pharmaceuticals, Llc Pharmaceutical formulations of a substituted diaminopurine
ITMI20112221A1 (it) * 2011-12-05 2013-06-06 Altergon Sa Formulazioni stabili in capsule di gelatina molle di antiaggreganti piastrinici, acidi grassi omega-3 e amilosio
WO2016090389A1 (en) * 2014-12-01 2016-06-09 Rathogwa Michael T Decongestant gum
US11278506B2 (en) * 2015-10-09 2022-03-22 Rb Health (Us) Llc Pharmaceutical formulation
EP3481379A4 (en) * 2016-07-05 2020-03-11 GlaxoSmithKline Consumer Healthcare Holdings (US) LLC ORAL GALENIC FORM CONTAINING A QUICK RELEASE EXTERIOR COATING
CN106727370A (zh) * 2016-12-07 2017-05-31 万全万特制药（厦门）有限公司 一种含有盐酸齐拉西酮的口崩片及其制备方法
WO2018207257A1 (ja) * 2017-05-09 2018-11-15 大塚製薬株式会社 包装薬剤
CN108670811A (zh) * 2018-05-22 2018-10-19 河南华冠新能源科技有限公司 量子自发热温灸理疗片配方及其制备方法
WO2020150460A1 (en) * 2019-01-18 2020-07-23 Milne Iii Donald A Micronized aspirin formulation
CN110279695B (zh) * 2019-08-07 2022-04-08 北京博智绿洲医药科技有限公司 一种治疗流涕、鼻塞等感冒症状的药物组合物及其制备方法和用途
CN111214449B (zh) * 2020-03-02 2021-09-07 广东彼迪药业有限公司 一种盐酸西替利嗪片剂及其制备方法

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US2881113A (en) * 1957-01-29 1959-04-07 Ortho Pharma Corp Therapeutically active compositions containing amphetamines
BE611639A (zh) * 1960-12-28
US3352752A (en) * 1963-07-25 1967-11-14 Tintex Corp Intestinal adsorbent compositions
US3337402A (en) * 1963-09-03 1967-08-22 Hoffmann La Roche Stable and palatable pharmaceutical composition
US3337403A (en) * 1963-09-05 1967-08-22 Hoffmann La Roche Stable and palatable pharmaceutical compositions
US3449266A (en) * 1964-05-25 1969-06-10 Drackett Co Stabilized solid granular perfume composition
US3272594A (en) * 1965-10-22 1966-09-13 Merck & Co Inc Preparation of magnesium trisilicate
US3567819A (en) * 1969-01-30 1971-03-02 Hoffmann La Roche Cold tablet
US3636200A (en) * 1969-06-09 1972-01-18 Hoffmann La Roche Pharmaceutical suspension
IL58462A0 (en) * 1978-10-27 1980-01-31 Beecham Group Ltd Intramammary compositions comprising a penicillin
US4327076A (en) * 1980-11-17 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
US4327077A (en) * 1981-05-29 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
US4581232A (en) * 1983-07-20 1986-04-08 Warner-Lambert Company Magnesium trisilicate suitable for preparation of medicament adsorbates
US4493827A (en) * 1983-11-14 1985-01-15 Ronald Valle Method of inducing sleep
US4910023A (en) * 1988-06-09 1990-03-20 Warner-Lambert Company Drug in combination with flavor masking agent and method for making same
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
WO1999063969A1 (en) * 1998-06-08 1999-12-16 Groenewoud Pieter J Stabilized thyroxine medications
US6399101B1 (en) * 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
SI21221A (sl) * 2002-06-21 2003-12-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Hitro razpadljive tablete
MXPA05005781A (es) * 2002-11-29 2005-12-12 Forest Laboratories Combinacion de ibuprofeno y oxicodona para alivio de dolor agudo.
US20040162273A1 (en) * 2003-01-23 2004-08-19 The Procter & Gamble Company Powder pharmaceutical compositions
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets

Also Published As

Publication number Publication date
US20060127473A1 (en) 2006-06-15
AR052153A1 (es) 2007-03-07
KR20080013847A (ko) 2008-02-13
NZ555909A (en) 2009-11-27
CA2590834A1 (en) 2006-06-22
CN101262852A (zh) 2008-09-10
WO2006064327A1 (en) 2006-06-22
ZA200705750B (en) 2008-11-26
JP2008523044A (ja) 2008-07-03
RU2391115C2 (ru) 2010-06-10
RU2007126652A (ru) 2009-01-20
BRPI0518553A2 (pt) 2008-11-25
EP1874275A1 (en) 2008-01-09
AU2005315291A1 (en) 2006-06-22
MX2007007069A (es) 2008-01-30

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