TW200401638A - Heterocyclic inhibitors of kinases - Google Patents

Info

Publication number

TW200401638A

TW200401638A TW092116280A TW92116280A TW200401638A TW 200401638 A TW200401638 A TW 200401638A TW 092116280 A TW092116280 A TW 092116280A TW 92116280 A TW92116280 A TW 92116280A TW 200401638 A TW200401638 A TW 200401638A

Authority

TW

Taiwan

Prior art keywords

ylamino

substituted

amino

ylmethyl

thiazol

Prior art date

2002-06-20

Links

• Espacenet
• Global Dossier
• Discuss

• 125000000623 heterocyclic group Chemical group 0.000 title claims description 41
• 239000003112 inhibitor Substances 0.000 title claims description 15
• 108091000080 Phosphotransferase Proteins 0.000 title description 8
• 102000020233 phosphotransferase Human genes 0.000 title description 8
• 150000001875 compounds Chemical class 0.000 claims abstract description 139
• 230000000694 effects Effects 0.000 claims abstract description 23
• 150000003839 salts Chemical class 0.000 claims abstract description 21
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• BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 claims abstract description 13
• 201000010099 disease Diseases 0.000 claims abstract description 13
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• 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 claims abstract description 12
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• 239000002246 antineoplastic agent Substances 0.000 claims abstract description 8
• -1 pyridin-2-ylamino Chemical group 0.000 claims description 158
• 239000000203 mixture Substances 0.000 claims description 80
• 125000003118 aryl group Chemical group 0.000 claims description 30
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 27
• 125000003107 substituted aryl group Chemical group 0.000 claims description 25
• 125000000217 alkyl group Chemical group 0.000 claims description 24
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 21
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• 125000001424 substituent group Chemical group 0.000 claims description 15
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• 239000001257 hydrogen Substances 0.000 claims description 14
• 229910052739 hydrogen Inorganic materials 0.000 claims description 14
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• 239000000651 prodrug Substances 0.000 claims description 11
• 229910052717 sulfur Inorganic materials 0.000 claims description 10
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• 125000000547 substituted alkyl group Chemical group 0.000 claims description 9
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• 125000004076 pyridyl group Chemical group 0.000 claims description 8
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