TR201809040T4 - Solid tümörlerin tedavisi. - Google Patents
Solid tümörlerin tedavisi. Download PDFInfo
- Publication number
- TR201809040T4 TR201809040T4 TR2018/09040T TR201809040T TR201809040T4 TR 201809040 T4 TR201809040 T4 TR 201809040T4 TR 2018/09040 T TR2018/09040 T TR 2018/09040T TR 201809040 T TR201809040 T TR 201809040T TR 201809040 T4 TR201809040 T4 TR 201809040T4
- Authority
- TR
- Turkey
- Prior art keywords
- cells
- treatment
- mcs
- compound
- hct116
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 30
- 150000001875 compounds Chemical class 0.000 claims abstract description 25
- 201000011510 cancer Diseases 0.000 claims description 9
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 60
- 210000002236 cellular spheroid Anatomy 0.000 description 25
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 10
- 239000002356 single layer Substances 0.000 description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 230000006698 induction Effects 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 230000035899 viability Effects 0.000 description 8
- 230000004900 autophagic degradation Effects 0.000 description 7
- 231100000135 cytotoxicity Toxicity 0.000 description 6
- 230000003013 cytotoxicity Effects 0.000 description 6
- 230000014509 gene expression Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- CDEURGJCGCHYFH-DJLDLDEBSA-N 5-ethynyl-2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C#C)=C1 CDEURGJCGCHYFH-DJLDLDEBSA-N 0.000 description 5
- 102000011727 Caspases Human genes 0.000 description 5
- 108010076667 Caspases Proteins 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000002246 antineoplastic agent Substances 0.000 description 5
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 4
- 102000013563 Acid Phosphatase Human genes 0.000 description 4
- 108010051457 Acid Phosphatase Proteins 0.000 description 4
- 102000003952 Caspase 3 Human genes 0.000 description 4
- 108090000397 Caspase 3 Proteins 0.000 description 4
- 108020004459 Small interfering RNA Proteins 0.000 description 4
- 230000006907 apoptotic process Effects 0.000 description 4
- 230000030833 cell death Effects 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- XDHNQDDQEHDUTM-XJKSCTEHSA-N (3z,5e,7r,8s,9r,11e,13e,15s,16r)-16-[(2s,3r,4s)-4-[(2r,4r,5s,6r)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one Chemical compound CO[C@H]1\C=C\C=C(C)\C[C@@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](O)C1 XDHNQDDQEHDUTM-XJKSCTEHSA-N 0.000 description 3
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- XDHNQDDQEHDUTM-UHFFFAOYSA-N bafliomycin A1 Natural products COC1C=CC=C(C)CC(C)C(O)C(C)C=C(C)C=C(OC)C(=O)OC1C(C)C(O)C(C)C1(O)OC(C(C)C)C(C)C(O)C1 XDHNQDDQEHDUTM-UHFFFAOYSA-N 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- OEUUFNIKLCFNLN-LLVKDONJSA-N chembl432481 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC(O)=CC=2)O)=N1 OEUUFNIKLCFNLN-LLVKDONJSA-N 0.000 description 3
- 229960003677 chloroquine Drugs 0.000 description 3
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000026731 phosphorylation Effects 0.000 description 3
- 238000006366 phosphorylation reaction Methods 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- WVWOOAYQYLJEFD-UHFFFAOYSA-N 1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol Chemical compound C1=CN=C([N+]([O-])=O)N1CC(O)CN1CCCCC1 WVWOOAYQYLJEFD-UHFFFAOYSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 2
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 2
- 102100034836 Proliferation marker protein Ki-67 Human genes 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000004264 monolayer culture Methods 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000036284 oxygen consumption Effects 0.000 description 2
- 229950010456 pimonidazole Drugs 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- MTAWKURMWOXCEO-UHFFFAOYSA-N taspine Chemical compound O1C(=O)C2=C(CCN(C)C)C=C(OC)C3=C2C2=C1C(OC)=CC=C2C(=O)O3 MTAWKURMWOXCEO-UHFFFAOYSA-N 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- QPOUCHIQTFZFLC-JNKAUUNZSA-N 1-[(3s,8r,9s,10s,13s,14s,17s)-17-(dimethylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]-3-[2-phenyl-1-(1,3-thiazol-2-yl)ethyl]urea Chemical compound N([C@@H]1CC2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)N(C)C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 QPOUCHIQTFZFLC-JNKAUUNZSA-N 0.000 description 1
- IUCNQFHEWLYECJ-FNAJZLPOSA-L Atractyloside Chemical compound [K+].[K+].O1[C@H](CO)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H](OC(=O)CC(C)C)[C@@H]1O[C@H]1C[C@@]2(C)[C@@H]3CC[C@@H](C(=C)[C@@H]4O)C[C@]34CC[C@@H]2[C@H](C(O)=O)C1 IUCNQFHEWLYECJ-FNAJZLPOSA-L 0.000 description 1
- 102100035656 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 Human genes 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 101100325855 Caenorhabditis elegans bec-1 gene Proteins 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101000803294 Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 Proteins 0.000 description 1
- 101000945496 Homo sapiens Proliferation marker protein Ki-67 Proteins 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 108010020437 Ki-67 Antigen Proteins 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 101100338491 Oryza sativa subsp. japonica HCT1 gene Proteins 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 238000011579 SCID mouse model Methods 0.000 description 1
- 101100495309 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CDH1 gene Proteins 0.000 description 1
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 1
- 102000044159 Ubiquitin Human genes 0.000 description 1
- 108090000848 Ubiquitin Proteins 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- FYQXODZRNSCOTR-UHFFFAOYSA-N atractyloside Natural products O1C(CO)C(OS(O)(=O)=O)C(OS(O)(=O)=O)C(OC(=O)CC(C)C)C1OC1CC2(C)C3CCC(C(=C)C4O)CC34CCC2C(C(O)=O)C1 FYQXODZRNSCOTR-UHFFFAOYSA-N 0.000 description 1
- 230000009789 autophagic cell death Effects 0.000 description 1
- 210000004957 autophagosome Anatomy 0.000 description 1
- 230000005033 autophagosome formation Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000003021 clonogenic effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000081 effect on glucose Effects 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000012835 hanging drop method Methods 0.000 description 1
- 201000003911 head and neck carcinoma Diseases 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229940080817 rotenone Drugs 0.000 description 1
- JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1100201 | 2011-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201809040T4 true TR201809040T4 (tr) | 2018-07-23 |
Family
ID=46879602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2018/09040T TR201809040T4 (tr) | 2011-03-21 | 2012-03-14 | Solid tümörlerin tedavisi. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20140073645A1 (enExample) |
| EP (1) | EP2688569B1 (enExample) |
| JP (1) | JP6064215B2 (enExample) |
| KR (1) | KR101937279B1 (enExample) |
| CN (1) | CN103547268B (enExample) |
| AU (1) | AU2012231814B2 (enExample) |
| BR (1) | BR112013024211B1 (enExample) |
| CA (1) | CA2830081C (enExample) |
| DK (1) | DK2688569T3 (enExample) |
| EA (1) | EA025180B1 (enExample) |
| ES (1) | ES2681703T3 (enExample) |
| HU (1) | HUE039021T2 (enExample) |
| IL (1) | IL228411A (enExample) |
| MX (1) | MX2013010770A (enExample) |
| PL (1) | PL2688569T3 (enExample) |
| PT (1) | PT2688569T (enExample) |
| SG (2) | SG193494A1 (enExample) |
| TR (1) | TR201809040T4 (enExample) |
| WO (1) | WO2012128689A1 (enExample) |
| ZA (1) | ZA201307036B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2884832C (en) * | 2012-09-21 | 2020-09-15 | Vivolux Ab | Means and method for treating solid tumours |
| US12383518B2 (en) | 2013-11-03 | 2025-08-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Disulfide-masked pro-chelator compositions and methods of use |
| US11504346B2 (en) | 2013-11-03 | 2022-11-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redox-activated pro-chelators |
| CN105807976B (zh) | 2014-12-31 | 2019-02-12 | 清华大学 | 静电传感器 |
| CN107847534B (zh) * | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| CN104997777A (zh) * | 2015-07-24 | 2015-10-28 | 孔小乐 | 去铁酮的2比1锌络合物作为制备抗癌药物的应用 |
| JP7103745B2 (ja) * | 2015-10-05 | 2022-07-20 | 国立大学法人 岡山大学 | 癌幹細胞抑制剤、癌の転移又は再発の抑制剤並びに癌細胞の未分化マーカー発現抑制剤 |
| HUE059610T2 (hu) | 2015-12-18 | 2022-12-28 | Vivolux Ab | Gyógyszerészeti készítmény, amely indolszármazékokat tartalmaz, valamint eljárás annak elõállítására és felhasználására |
| WO2018119207A1 (en) * | 2016-12-21 | 2018-06-28 | The Medical College Of Wisconsin, Inc. | Synergistic inihibition of tumor cell proliferation induced by combined treatment of metformin compounds and iron chelators |
| WO2018147612A1 (ko) * | 2017-02-07 | 2018-08-16 | 주식회사 온코크로스 | 암의 전이 억제 및 치료용 조성물 |
| KR101859922B1 (ko) * | 2017-02-07 | 2018-05-21 | 주식회사 온코크로스 | 클로페네신을 포함하는 대장암 증식 및 전이 억제용 조성물 |
| CN106831776B (zh) * | 2017-03-16 | 2018-12-07 | 河北科技大学 | 5,10-二氢吡啶并吡嗪并三嗪类化合物及其应用 |
| WO2019101897A1 (en) * | 2017-11-23 | 2019-05-31 | Deutsches Krebsforschungszentrum | Iron chelators in tumor therapy |
| CN109646679A (zh) * | 2019-01-28 | 2019-04-19 | 中国科学院长春应用化学研究所 | 铁离子螯合剂及其可药用盐的用途 |
| CN110585194A (zh) * | 2019-10-12 | 2019-12-20 | 广州医科大学附属第五医院 | 倍半萜内酯类化合物在制备溶酶体自噬抑制剂以及抗癌药物中的应用 |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| CN111849873A (zh) * | 2020-07-30 | 2020-10-30 | 扬州大学 | 一种诱导鸡的胚胎干细胞自噬的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4831038A (en) * | 1986-01-13 | 1989-05-16 | Ire-Celltarg S.A. | Vinblastine derivatives and pharmaceutical composition containing them |
| US5480906A (en) * | 1994-07-01 | 1996-01-02 | Eli Lilly And Company | Stereochemical Wortmannin derivatives |
| IL121272A (en) * | 1997-07-10 | 2000-06-01 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia |
| US6660737B2 (en) * | 2001-05-04 | 2003-12-09 | The Procter & Gamble Company | Medicinal uses of hydrazones |
| JP2006516979A (ja) * | 2003-02-05 | 2006-07-13 | ニューサウス イノベーションズ ピーティーワイ リミテッド | 金属イオンキレート化剤およびその治療的使用 |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| WO2006055412A1 (en) | 2004-11-19 | 2006-05-26 | Shiva Biomedical, Llc | Methods of treating erythropoietin-resistance |
| BRPI0711385A2 (pt) * | 2006-05-09 | 2011-11-08 | Novartis Ag | combinação compreendendo um quelante de ferro e um agente anti-neoplástico e seu uso |
| WO2009035534A2 (en) * | 2007-09-07 | 2009-03-19 | The Cleveland Clinic Foundation | Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif) |
| KR101208587B1 (ko) * | 2009-06-24 | 2012-12-06 | 여오영 | 하이드록시클로로퀸을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물 |
| CA2884832C (en) | 2012-09-21 | 2020-09-15 | Vivolux Ab | Means and method for treating solid tumours |
-
2012
- 2012-03-14 ES ES12760260.5T patent/ES2681703T3/es active Active
- 2012-03-14 CN CN201280024388.8A patent/CN103547268B/zh active Active
- 2012-03-14 MX MX2013010770A patent/MX2013010770A/es active IP Right Grant
- 2012-03-14 EP EP12760260.5A patent/EP2688569B1/en active Active
- 2012-03-14 CA CA2830081A patent/CA2830081C/en active Active
- 2012-03-14 PL PL12760260T patent/PL2688569T3/pl unknown
- 2012-03-14 KR KR1020137027532A patent/KR101937279B1/ko active Active
- 2012-03-14 PT PT127602605T patent/PT2688569T/pt unknown
- 2012-03-14 SG SG2013069729A patent/SG193494A1/en unknown
- 2012-03-14 EA EA201391286A patent/EA025180B1/ru not_active IP Right Cessation
- 2012-03-14 HU HUE12760260A patent/HUE039021T2/hu unknown
- 2012-03-14 AU AU2012231814A patent/AU2012231814B2/en active Active
- 2012-03-14 TR TR2018/09040T patent/TR201809040T4/tr unknown
- 2012-03-14 DK DK12760260.5T patent/DK2688569T3/en active
- 2012-03-14 WO PCT/SE2012/000034 patent/WO2012128689A1/en not_active Ceased
- 2012-03-14 JP JP2014501035A patent/JP6064215B2/ja active Active
- 2012-03-14 US US14/006,277 patent/US20140073645A1/en not_active Abandoned
- 2012-03-14 SG SG10201605083SA patent/SG10201605083SA/en unknown
- 2012-03-14 BR BR112013024211-6A patent/BR112013024211B1/pt active IP Right Grant
-
2013
- 2013-09-12 IL IL228411A patent/IL228411A/en active IP Right Revival
- 2013-09-18 ZA ZA2013/07036A patent/ZA201307036B/en unknown
-
2017
- 2017-06-16 US US15/625,337 patent/US10022380B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140017619A (ko) | 2014-02-11 |
| JP6064215B2 (ja) | 2017-02-01 |
| ZA201307036B (en) | 2014-05-28 |
| CA2830081A1 (en) | 2012-09-27 |
| KR101937279B1 (ko) | 2019-01-10 |
| US10022380B2 (en) | 2018-07-17 |
| AU2012231814A1 (en) | 2013-09-26 |
| EA201391286A1 (ru) | 2014-03-31 |
| BR112013024211B1 (pt) | 2020-12-15 |
| SG10201605083SA (en) | 2016-08-30 |
| US20140073645A1 (en) | 2014-03-13 |
| SG193494A1 (en) | 2013-10-30 |
| BR112013024211A2 (pt) | 2016-12-20 |
| PL2688569T3 (pl) | 2018-09-28 |
| CN103547268A (zh) | 2014-01-29 |
| CA2830081C (en) | 2020-09-22 |
| DK2688569T3 (en) | 2018-08-06 |
| IL228411A (en) | 2016-12-29 |
| ES2681703T3 (es) | 2018-09-14 |
| EA025180B1 (ru) | 2016-11-30 |
| AU2012231814B2 (en) | 2016-06-09 |
| HUE039021T2 (hu) | 2018-12-28 |
| JP2014508804A (ja) | 2014-04-10 |
| WO2012128689A1 (en) | 2012-09-27 |
| EP2688569B1 (en) | 2018-05-30 |
| IL228411A0 (en) | 2013-12-31 |
| US20170348317A1 (en) | 2017-12-07 |
| CN103547268B (zh) | 2017-02-22 |
| PT2688569T (pt) | 2018-08-06 |
| EP2688569A4 (en) | 2014-09-10 |
| MX2013010770A (es) | 2014-03-27 |
| EP2688569A1 (en) | 2014-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR201809040T4 (tr) | Solid tümörlerin tedavisi. | |
| Yuan et al. | Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells | |
| Tandon et al. | Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells | |
| Crea et al. | Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer | |
| Jia et al. | β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer | |
| Kim et al. | Inhibition of tumor growth and angiogenesis of tamoxifen-resistant breast cancer cells by ruxolitinib, a selective JAK2 inhibitor | |
| Feng et al. | Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway | |
| Perez-Lorenzo et al. | A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms | |
| Hung et al. | Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential | |
| Chen et al. | Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma | |
| Xi et al. | HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo | |
| Kim et al. | Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3 | |
| Kindt et al. | Pharmacological inhibition of macrophage migration inhibitory factor interferes with the proliferation and invasiveness of squamous carcinoma cells | |
| JP2023175773A (ja) | 微小残存がんを治療する方法 | |
| Yue et al. | α‐lipoic acid targeting PDK1/NRF2 axis contributes to the apoptosis effect of lung cancer cells | |
| US12352752B2 (en) | Application of Niemann-Pick C1 protein in diagnosis and treatment of cancer | |
| Kashyap et al. | In vitro anticancer efficacy of a polyphenolic combination of Quercetin, Curcumin, and Berberine in triple negative breast cancer (TNBC) cells | |
| Sun et al. | Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1 | |
| da Costa et al. | Src kinase activation by nitric oxide promotes resistance to anoikis in tumour cell lines | |
| Shen et al. | Effect of claudin 1 on cell proliferation, migration and apoptosis in human cervical squamous cell carcinoma | |
| CN114949226B (zh) | B7-h3基因抑制剂在制备治疗非小细胞肺癌药物中的应用 | |
| Brown et al. | Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma | |
| Mitchell et al. | Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling | |
| Hung et al. | The exosomal compartment protects epidermal growth factor receptor from small molecule inhibitors | |
| Jiang et al. | MYCL promotes the progression of triple‑negative breast cancer by activating the JAK/STAT3 pathway |