EA201391286A1 - Лечение солидных опухолей - Google Patents

Лечение солидных опухолей

Info

Publication number
EA201391286A1
EA201391286A1 EA201391286A EA201391286A EA201391286A1 EA 201391286 A1 EA201391286 A1 EA 201391286A1 EA 201391286 A EA201391286 A EA 201391286A EA 201391286 A EA201391286 A EA 201391286A EA 201391286 A1 EA201391286 A1 EA 201391286A1
Authority
EA
Eurasian Patent Office
Prior art keywords
agent
iron chelator
inhibits autophagy
chelator
possibly
Prior art date
Application number
EA201391286A
Other languages
English (en)
Other versions
EA025180B1 (ru
Inventor
Стиг Линдер
Мортен Фрикнес
Рольф Ларссон
Original Assignee
Виволюкс Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Виволюкс Аб filed Critical Виволюкс Аб
Publication of EA201391286A1 publication Critical patent/EA201391286A1/ru
Publication of EA025180B1 publication Critical patent/EA025180B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Хелатор железа, способный проникать в клетку, возможно в комбинации с агентом, ингибирующим аутофагию, применяют для лечения солидной раковой опухоли у субъекта. Предпочтительный хелатор представляет собой замещенный алкилом N-(1-пиридин-2-илметилиден)-N-(9Н-1,3,4,9-тетраазафлуорен-2-ил)гидразин. Предпочтительный агент, ингибирующий аутофагию, представляет собой хлорохин. Также раскрыта фармацевтическая композиция, включающая хелатор железа, фармацевтически приемлемый носитель и, возможно, агент, ингибирующий аутофагию; и способ лечения рака путем введения эффективного(ных) для борьбы с раком количества (количеств) хелатора железа или комбинации хелатора железа и агента, ингибирующего аутофагию.
EA201391286A 2011-03-21 2012-03-14 Лечение солидных опухолей EA025180B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1100201 2011-03-21
PCT/SE2012/000034 WO2012128689A1 (en) 2011-03-21 2012-03-14 Treatment of solid tumours

Publications (2)

Publication Number Publication Date
EA201391286A1 true EA201391286A1 (ru) 2014-03-31
EA025180B1 EA025180B1 (ru) 2016-11-30

Family

ID=46879602

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391286A EA025180B1 (ru) 2011-03-21 2012-03-14 Лечение солидных опухолей

Country Status (20)

Country Link
US (2) US20140073645A1 (ru)
EP (1) EP2688569B1 (ru)
JP (1) JP6064215B2 (ru)
KR (1) KR101937279B1 (ru)
CN (1) CN103547268B (ru)
AU (1) AU2012231814B2 (ru)
BR (1) BR112013024211B1 (ru)
CA (1) CA2830081C (ru)
DK (1) DK2688569T3 (ru)
EA (1) EA025180B1 (ru)
ES (1) ES2681703T3 (ru)
HU (1) HUE039021T2 (ru)
IL (1) IL228411A (ru)
MX (1) MX2013010770A (ru)
PL (1) PL2688569T3 (ru)
PT (1) PT2688569T (ru)
SG (2) SG10201605083SA (ru)
TR (1) TR201809040T4 (ru)
WO (1) WO2012128689A1 (ru)
ZA (1) ZA201307036B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE044767T2 (hu) * 2012-09-21 2019-11-28 Vivolux Ab Módszerek és eljárás szolid tumorok kezelésére
US11504346B2 (en) 2013-11-03 2022-11-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Redox-activated pro-chelators
CN105807976B (zh) 2014-12-31 2019-02-12 清华大学 静电传感器
US10548930B2 (en) * 2015-04-17 2020-02-04 Memorial Sloan Kettering Cancer Center Use of MVA or MVAΔE3L as immunotherapeutic agents against solid tumors
CN104997777A (zh) * 2015-07-24 2015-10-28 孔小乐 去铁酮的2比1锌络合物作为制备抗癌药物的应用
JP7103745B2 (ja) * 2015-10-05 2022-07-20 国立大学法人 岡山大学 癌幹細胞抑制剤、癌の転移又は再発の抑制剤並びに癌細胞の未分化マーカー発現抑制剤
CA3008084A1 (en) 2015-12-18 2017-06-22 Vivolux Ab Pharmaceutical composition comprising indole derivatives, process for preparation and use thereof
US20190358247A1 (en) * 2016-12-21 2019-11-28 The Medical College Of Wisconsin, Inc. Synergistic inihibition of tumor cell proliferation induced by combined treatment of metformin or metformin analogs and iron chelators
KR101859922B1 (ko) * 2017-02-07 2018-05-21 주식회사 온코크로스 클로페네신을 포함하는 대장암 증식 및 전이 억제용 조성물
US11364237B2 (en) * 2017-02-07 2022-06-21 Oncocross Co., Ltd. Composition for inhibiting cancer metastasis and treating cancer
CN106831776B (zh) * 2017-03-16 2018-12-07 河北科技大学 5,10-二氢吡啶并吡嗪并三嗪类化合物及其应用
WO2019101897A1 (en) * 2017-11-23 2019-05-31 Deutsches Krebsforschungszentrum Iron chelators in tumor therapy
CN109646679A (zh) * 2019-01-28 2019-04-19 中国科学院长春应用化学研究所 铁离子螯合剂及其可药用盐的用途
CN110585194A (zh) * 2019-10-12 2019-12-20 广州医科大学附属第五医院 倍半萜内酯类化合物在制备溶酶体自噬抑制剂以及抗癌药物中的应用
CN111849873A (zh) * 2020-07-30 2020-10-30 扬州大学 一种诱导鸡的胚胎干细胞自噬的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0233101A1 (fr) * 1986-01-13 1987-08-19 Ire-Celltarg S.A. Dérivés de vinblastine et composition pharmaceutique les contenant
US5480906A (en) * 1994-07-01 1996-01-02 Eli Lilly And Company Stereochemical Wortmannin derivatives
IL121272A (en) * 1997-07-10 2000-06-01 Can Fite Technologies Ltd Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia
US6660737B2 (en) * 2001-05-04 2003-12-09 The Procter & Gamble Company Medicinal uses of hydrazones
US20060252798A1 (en) * 2003-02-05 2006-11-09 Richardson Desi R Metal ion chelators and therapeutic use thereof
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
JP2008520669A (ja) * 2004-11-19 2008-06-19 シバ バイオメディカル，エルエルシー エリスロポエチン抵抗性を治療する方法
MX2008014292A (es) * 2006-05-09 2008-11-18 Novartis Ag Combinacion que comprende un quelante de hierro y un agente anti-neoplastico, y uso de la misma.
WO2009035534A2 (en) * 2007-09-07 2009-03-19 The Cleveland Clinic Foundation Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif)
KR101208587B1 (ko) * 2009-06-24 2012-12-06 여오영 하이드록시클로로퀸을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물
HUE044767T2 (hu) 2012-09-21 2019-11-28 Vivolux Ab Módszerek és eljárás szolid tumorok kezelésére

Also Published As

Publication number Publication date
ES2681703T3 (es) 2018-09-14
SG193494A1 (en) 2013-10-30
CA2830081C (en) 2020-09-22
PL2688569T3 (pl) 2018-09-28
JP6064215B2 (ja) 2017-02-01
US10022380B2 (en) 2018-07-17
IL228411A (en) 2016-12-29
AU2012231814A1 (en) 2013-09-26
ZA201307036B (en) 2014-05-28
CN103547268B (zh) 2017-02-22
US20170348317A1 (en) 2017-12-07
BR112013024211A2 (pt) 2016-12-20
EP2688569A1 (en) 2014-01-29
CA2830081A1 (en) 2012-09-27
BR112013024211B1 (pt) 2020-12-15
EA025180B1 (ru) 2016-11-30
MX2013010770A (es) 2014-03-27
EP2688569A4 (en) 2014-09-10
KR20140017619A (ko) 2014-02-11
EP2688569B1 (en) 2018-05-30
JP2014508804A (ja) 2014-04-10
US20140073645A1 (en) 2014-03-13
CN103547268A (zh) 2014-01-29
WO2012128689A1 (en) 2012-09-27
HUE039021T2 (hu) 2018-12-28
SG10201605083SA (en) 2016-08-30
PT2688569T (pt) 2018-08-06
DK2688569T3 (en) 2018-08-06
IL228411A0 (en) 2013-12-31
KR101937279B1 (ko) 2019-01-10
TR201809040T4 (tr) 2018-07-23
AU2012231814B2 (en) 2016-06-09

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM