TR200402517T2 - HBV ilaç direnci tespit metotları - Google Patents

HBV ilaç direnci tespit metotları

Info

Publication number
TR200402517T2
TR200402517T2 TR2004/02517T TR200402517T TR200402517T2 TR 200402517 T2 TR200402517 T2 TR 200402517T2 TR 2004/02517 T TR2004/02517 T TR 2004/02517T TR 200402517 T TR200402517 T TR 200402517T TR 200402517 T2 TR200402517 T2 TR 200402517T2
Authority
TR
Turkey
Prior art keywords
hbv
nucleic acid
relates
drug resistance
detection methods
Prior art date
Application number
TR2004/02517T
Other languages
English (en)
Other versions
TR200402517T1 (tr
Inventor
Abdurrahman Bozdayi Mi̇that
Original Assignee
Innogenetics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics N.V. filed Critical Innogenetics N.V.
Publication of TR200402517T2 publication Critical patent/TR200402517T2/tr
Publication of TR200402517T1 publication Critical patent/TR200402517T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Buluş izole edilmiş bir HBV polinükleik asidi ya da onun bir parçasına ilişkin olup, özelliği, HBV ters transkriptaz alanının kodon 204'ünü içermesi, bu kodon 204'ün de bir serini kodlamasıdır. Mevcut buluş ayrıca, söz konusu DNA nükleik asit polimorfizmlerine ek olarak kullanılan oligonükleotidleri içeren HBV soylarının biyolojik bir örneğindeki güvenilir bir tespit için olan metotlarla ilgilidir. Buluş, ayrıca, HBV nükleik asit polimorfizmlerini içeren HBV varyantlarının antiviral bileşiklerine karşı hassasiyeti test eden metotlara ek olarak, HBV nükleik asit polimorfizmlerini içeren vektörlere ilişkindir.
TR2004/02517T 2002-03-29 2002-03-29 HBV ilaç direnci tespit metotları TR200402517T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2002/003559 WO2003083094A1 (en) 2002-03-29 2002-03-29 Hbv drug resistance drug resistance detection methods

Publications (2)

Publication Number Publication Date
TR200402517T2 true TR200402517T2 (tr) 2007-01-22
TR200402517T1 TR200402517T1 (tr) 2007-12-24

Family

ID=28459435

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/02517T TR200402517T1 (tr) 2002-03-29 2002-03-29 HBV ilaç direnci tespit metotları

Country Status (5)

Country Link
US (2) US8278432B2 (tr)
AU (1) AU2002308114A1 (tr)
CA (1) CA2480382C (tr)
TR (1) TR200402517T1 (tr)
WO (1) WO2003083094A1 (tr)

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CN101203528A (zh) 2005-03-15 2008-06-18 基因创新有限公司 对核苷类似物敏感性降低的乙型肝炎病毒变异体及其用途
EP1858915B1 (en) * 2005-03-15 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Variants of hepatitis b virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof
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US9297033B2 (en) * 2013-12-13 2016-03-29 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using hydrolysis probes with 3′ hairpin structure
CN111118210A (zh) * 2018-10-31 2020-05-08 深圳华大因源医药科技有限公司 乙型肝炎病毒基因组突变检测方法及试剂盒和应用
CN110195129B (zh) * 2019-06-05 2023-04-07 中国人民解放军军事科学院军事医学研究院 一种靶向hbv耐药突变基因的pcr-crispr检测方法

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Also Published As

Publication number Publication date
TR200402517T1 (tr) 2007-12-24
WO2003083094A1 (en) 2003-10-09
US8278432B2 (en) 2012-10-02
US20130040284A1 (en) 2013-02-14
US8686126B2 (en) 2014-04-01
CA2480382A1 (en) 2003-10-09
US20060165725A1 (en) 2006-07-27
CA2480382C (en) 2015-12-22
AU2002308114A1 (en) 2003-10-13

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