TR200402470T4 - Aminometil-aril-sikloheksanol-türevlerinin enzimatik rasemat ayırma yöntemi. - Google Patents

Aminometil-aril-sikloheksanol-türevlerinin enzimatik rasemat ayırma yöntemi.

Info

Publication number
TR200402470T4
TR200402470T4 TR2004/02470T TR200402470T TR200402470T4 TR 200402470 T4 TR200402470 T4 TR 200402470T4 TR 2004/02470 T TR2004/02470 T TR 2004/02470T TR 200402470 T TR200402470 T TR 200402470T TR 200402470 T4 TR200402470 T4 TR 200402470T4
Authority
TR
Turkey
Prior art keywords
aminomethyl
aryl
cyclohexanol derivatives
racemate separation
enzymatic racemate
Prior art date
Application number
TR2004/02470T
Other languages
English (en)
Inventor
Buschmann Helmut
Kaulartz Dagmar
Griebel Carsten
Gais Hans-Joachim
Original Assignee
Grnenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7629816&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200402470(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grnenthal Gmbh filed Critical Grnenthal Gmbh
Publication of TR200402470T4 publication Critical patent/TR200402470T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bu bulus, bir aminometil-aril-sikloheksanol-türevlerinin enzimatik resemat ayirma yöntemiyle ilgilidir.
TR2004/02470T 2000-02-04 2001-01-18 Aminometil-aril-sikloheksanol-türevlerinin enzimatik rasemat ayırma yöntemi. TR200402470T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10004926A DE10004926A1 (de) 2000-02-04 2000-02-04 Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten

Publications (1)

Publication Number Publication Date
TR200402470T4 true TR200402470T4 (tr) 2004-12-21

Family

ID=7629816

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/02470T TR200402470T4 (tr) 2000-02-04 2001-01-18 Aminometil-aril-sikloheksanol-türevlerinin enzimatik rasemat ayırma yöntemi.

Country Status (21)

Country Link
US (1) US7168937B2 (tr)
EP (1) EP1252327B1 (tr)
JP (1) JP2003528049A (tr)
AR (1) AR027327A1 (tr)
AT (1) ATE274599T1 (tr)
AU (2) AU2001230192B2 (tr)
CA (1) CA2399819C (tr)
CO (1) CO5271656A1 (tr)
DE (2) DE10004926A1 (tr)
DK (1) DK1252327T3 (tr)
ES (1) ES2227118T3 (tr)
HK (1) HK1051558A1 (tr)
HU (1) HUP0204430A3 (tr)
MX (1) MXPA02007594A (tr)
NZ (1) NZ521087A (tr)
PE (1) PE20011075A1 (tr)
PT (1) PT1252327E (tr)
SI (1) SI1252327T1 (tr)
TR (1) TR200402470T4 (tr)
UY (1) UY26574A1 (tr)
WO (1) WO2001057232A1 (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
DE10059413A1 (de) * 2000-11-30 2002-06-20 Gruenenthal Gmbh Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
ATE391498T1 (de) * 2002-11-22 2008-04-15 Gruenenthal Gmbh Verwendung von (1rs,3rs,6rs)-6- dimethylaminomethyl-1-(3-methoxy-phenyl)- cyclohexan-1,3-diol zur behandlung von entzündungsschmerz
US7094795B2 (en) 2003-02-27 2006-08-22 Sanofi-Aventis Deutschland Gmbh Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives
DE10308350B4 (de) * 2003-02-27 2006-06-01 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten
DE102004038403B4 (de) * 2004-08-07 2006-08-31 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten
US20060211887A1 (en) * 2005-02-25 2006-09-21 Gruenenthal Gmbh Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds
DE102007022790A1 (de) 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur Schmerzbehandlung bei Arthrose

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN162851B (tr) * 1980-09-19 1988-07-16 Pfizer
JP3049403B2 (ja) 1991-11-01 2000-06-05 チッソ株式会社 光学活性トランス−２−アリール−１−シクロヘキサノール誘導体およびその製造法
CA2068038A1 (en) 1991-05-08 1992-11-09 Christopher Yee Enzymatic resolution of .alpha.-tertiary carboxylic acid esters
CA2087359A1 (en) 1992-01-15 1993-07-16 Ramesh N. Patel Enzymatic processes for resolution of enantiomeric mixtures of compoundsuseful as intermediates in the preparation of taxanes
DE4217506A1 (de) 1992-05-27 1993-12-02 Boehringer Mannheim Gmbh Mikrobielle Esterase zur enantioselektiven Spaltung von 1-Arylalkylestern
ES2046950B1 (es) 1992-06-08 1994-10-01 Menarini Lab Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente.
JPH07101921A (ja) 1993-10-01 1995-04-18 Chisso Corp 光学活性トリフルオロメチルベンジルアルコール誘導体およびその製造法
DE4414273A1 (de) 1994-04-23 1995-10-26 Chemie Linz Deutschland Enzymatische Racematspaltung asymmetrischer Alkohole mittels Vinylestern mehrbasiger Carbonsäuren
US5696299A (en) 1994-10-26 1997-12-09 The Nisshin Oil Mills, Ltd. Optical resolution for producing optically active alcohol
EP0710725A1 (en) * 1994-11-01 1996-05-08 Takeda Chemical Industries, Ltd. Production of optically active compounds
JPH08322590A (ja) 1995-06-05 1996-12-10 Chisso Corp 光学活性２ー（１−ナフチル）シクロヘキサン−１−オール誘導体及びその製造方法
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
JPH09121564A (ja) 1995-10-27 1997-05-06 Kasei Optonix Co Ltd 静電アクチュエータ
DE19547766A1 (de) * 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
WO1998040053A1 (en) * 1997-03-11 1998-09-17 Darwin Discovery Limited Dosage forms comprising separate portions of r- and s-enantiomers

Also Published As

Publication number Publication date
AU2001230192B2 (en) 2006-07-13
EP1252327A1 (de) 2002-10-30
WO2001057232B1 (de) 2002-01-10
DE10004926A1 (de) 2001-08-09
AU3019201A (en) 2001-08-14
DE50103394D1 (de) 2004-09-30
HUP0204430A3 (en) 2005-05-30
SI1252327T1 (en) 2004-12-31
AR027327A1 (es) 2003-03-26
HUP0204430A2 (en) 2003-05-28
US7168937B2 (en) 2007-01-30
JP2003528049A (ja) 2003-09-24
EP1252327B1 (de) 2004-08-25
UY26574A1 (es) 2001-04-30
CO5271656A1 (es) 2003-04-30
ATE274599T1 (de) 2004-09-15
NZ521087A (en) 2005-11-25
CA2399819A1 (en) 2001-08-09
US20030186396A1 (en) 2003-10-02
HK1051558A1 (en) 2003-08-08
WO2001057232A1 (de) 2001-08-09
ES2227118T3 (es) 2005-04-01
MXPA02007594A (es) 2002-12-13
PT1252327E (pt) 2004-12-31
DK1252327T3 (da) 2004-11-01
PE20011075A1 (es) 2001-12-29
CA2399819C (en) 2011-04-12

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