ATE256696T1 - Neue cofaktoren für methyltransferasen - Google Patents

Neue cofaktoren für methyltransferasen

Info

Publication number
ATE256696T1
ATE256696T1 AT99938363T AT99938363T ATE256696T1 AT E256696 T1 ATE256696 T1 AT E256696T1 AT 99938363 T AT99938363 T AT 99938363T AT 99938363 T AT99938363 T AT 99938363T AT E256696 T1 ATE256696 T1 AT E256696T1
Authority
AT
Austria
Prior art keywords
methyl transferases
cofactors
new
new cofactors
transferases
Prior art date
Application number
AT99938363T
Other languages
English (en)
Inventor
Marc Pignot
Elmar Weinhold
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE256696T1 publication Critical patent/ATE256696T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048Pyridine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052Imidazole radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14Pyrrolo-pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00Reaction characterised by the enzymatic activity
    • C12Q2521/10Nucleotidyl transfering
    • C12Q2521/125Methyl transferase, i.e. methylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT99938363T 1998-07-29 1999-07-28 Neue cofaktoren für methyltransferasen ATE256696T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98114201 1998-07-29
PCT/EP1999/005405 WO2000006587A1 (en) 1998-07-29 1999-07-28 New cofactors for methyltransferases

Publications (1)

Publication Number Publication Date
ATE256696T1 true ATE256696T1 (de) 2004-01-15

Family

ID=8232369

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99938363T ATE256696T1 (de) 1998-07-29 1999-07-28 Neue cofaktoren für methyltransferasen

Country Status (10)

Country Link
US (1) US6875750B1 (de)
EP (1) EP1102781B1 (de)
JP (1) JP2002521488A (de)
AT (1) ATE256696T1 (de)
CA (1) CA2338721C (de)
DE (1) DE69913705T2 (de)
DK (1) DK1102781T3 (de)
ES (1) ES2211138T3 (de)
PT (1) PT1102781E (de)
WO (1) WO2000006587A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1251609A (zh) 1997-02-12 2000-04-26 尤金·Y·查恩 分析聚合物的方法和产品
US6927065B2 (en) 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
EP1402071A4 (de) * 2001-06-08 2005-12-14 Us Genomics Inc Verfahren und produkte zur analyse von nukleinsäuren auf grundlage des methylierungsstatus
CN101001864A (zh) * 2004-06-14 2007-07-18 马普科技促进协会 生物分子中甲基化的序列特异性检测
CA2592274C (en) * 2004-12-28 2014-09-09 Advanced Life Science Institute, Inc. Blocked enzyme-probe complex
US7465544B2 (en) * 2006-01-11 2008-12-16 Wisconsin Alumni Research Foundation Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use
US20100137154A1 (en) * 2008-12-01 2010-06-03 Ach Robert A Genome analysis using a methyltransferase
LT5708B (en) 2009-04-02 2011-01-25 Biotechnologijos Inst Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases
EP2577275A1 (de) 2010-06-04 2013-04-10 Katholieke Universiteit Leuven K.U. Leuven R&D Optisches mapping von genomischer dna
GB201119903D0 (en) 2011-11-17 2011-12-28 Univ Vilnius Nucleic acid production and sequence analysis
US12054771B2 (en) 2014-02-18 2024-08-06 Bionano Genomics, Inc. Methods of determining nucleic acid structural information
EP3497239A4 (de) 2016-08-10 2020-02-26 Ramot at Tel-Aviv University Ltd. Analyse des methylierungsstatus und kopienzahl

Also Published As

Publication number Publication date
PT1102781E (pt) 2004-04-30
US6875750B1 (en) 2005-04-05
EP1102781A1 (de) 2001-05-30
DK1102781T3 (da) 2004-04-05
ES2211138T3 (es) 2004-07-01
CA2338721A1 (en) 2000-02-10
JP2002521488A (ja) 2002-07-16
WO2000006587A1 (en) 2000-02-10
DE69913705D1 (de) 2004-01-29
EP1102781B1 (de) 2003-12-17
CA2338721C (en) 2008-11-18
DE69913705T2 (de) 2004-09-30

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