DE69913705D1 - Neue cofaktoren für methyltransferasen - Google Patents

Neue cofaktoren für methyltransferasen

Info

Publication number
DE69913705D1
DE69913705D1 DE69913705T DE69913705T DE69913705D1 DE 69913705 D1 DE69913705 D1 DE 69913705D1 DE 69913705 T DE69913705 T DE 69913705T DE 69913705 T DE69913705 T DE 69913705T DE 69913705 D1 DE69913705 D1 DE 69913705D1
Authority
DE
Germany
Prior art keywords
methyl transferases
cofactors
new
new cofactors
transferases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69913705T
Other languages
English (en)
Other versions
DE69913705T2 (de
Inventor
Marc Pignot
Elmar Weinhold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Application granted granted Critical
Publication of DE69913705D1 publication Critical patent/DE69913705D1/de
Publication of DE69913705T2 publication Critical patent/DE69913705T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/125—Methyl transferase, i.e. methylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69913705T 1998-07-29 1999-07-28 Neue cofaktoren für methyltransferasen Expired - Lifetime DE69913705T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98114201 1998-07-29
EP98114201 1998-07-29
PCT/EP1999/005405 WO2000006587A1 (en) 1998-07-29 1999-07-28 New cofactors for methyltransferases

Publications (2)

Publication Number Publication Date
DE69913705D1 true DE69913705D1 (de) 2004-01-29
DE69913705T2 DE69913705T2 (de) 2004-09-30

Family

ID=8232369

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69913705T Expired - Lifetime DE69913705T2 (de) 1998-07-29 1999-07-28 Neue cofaktoren für methyltransferasen

Country Status (10)

Country Link
US (1) US6875750B1 (de)
EP (1) EP1102781B1 (de)
JP (1) JP2002521488A (de)
AT (1) ATE256696T1 (de)
CA (1) CA2338721C (de)
DE (1) DE69913705T2 (de)
DK (1) DK1102781T3 (de)
ES (1) ES2211138T3 (de)
PT (1) PT1102781E (de)
WO (1) WO2000006587A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3935509B2 (ja) 1997-02-12 2007-06-27 ワイ． チャン，ユージーン ポリマー分析のための方法および製品
US6927065B2 (en) 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AU2002318336A1 (en) * 2001-06-08 2002-12-23 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
CN101001864A (zh) * 2004-06-14 2007-07-18 马普科技促进协会 生物分子中甲基化的序列特异性检测
US20080153089A1 (en) * 2004-12-28 2008-06-26 Advanced Life Science Institute, Inc. Blocked Enzyme-Probe Complex
US7465544B2 (en) 2006-01-11 2008-12-16 Wisconsin Alumni Research Foundation Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use
US20100137154A1 (en) * 2008-12-01 2010-06-03 Ach Robert A Genome analysis using a methyltransferase
LT5708B (en) 2009-04-02 2011-01-25 Biotechnologijos Inst Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases
WO2011150475A1 (en) 2010-06-04 2011-12-08 Katholieke Universiteit Leuven K.U. Leuven R&D Optical mapping of genomic dna
GB201119903D0 (en) 2011-11-17 2011-12-28 Univ Vilnius Nucleic acid production and sequence analysis
US20160369331A1 (en) 2014-02-18 2016-12-22 Bionano Genomics, Inc. Improved methods of determining nucleic acid structural information
WO2018029693A1 (en) 2016-08-10 2018-02-15 Ramot At Tel-Aviv University Ltd. Analysis of methylation status and copy number

Also Published As

Publication number Publication date
PT1102781E (pt) 2004-04-30
DE69913705T2 (de) 2004-09-30
ATE256696T1 (de) 2004-01-15
ES2211138T3 (es) 2004-07-01
EP1102781B1 (de) 2003-12-17
US6875750B1 (en) 2005-04-05
WO2000006587A1 (en) 2000-02-10
DK1102781T3 (da) 2004-04-05
EP1102781A1 (de) 2001-05-30
CA2338721C (en) 2008-11-18
CA2338721A1 (en) 2000-02-10
JP2002521488A (ja) 2002-07-16

Similar Documents

Publication Publication Date Title
BR9900177A (pt) Inibidores de metaloprotease.
ATE256696T1 (de) Neue cofaktoren für methyltransferasen
AR006390A1 (es) Derivados de lactama
PT1001930E (pt) Derivados de n-hidroxiformamida como inibidores de metaloproteinases de matriz
JO2654B1 (en) Multiple aryl caroxa amides are useful as lipid - lowering agents
GB9919776D0 (en) Compoujnds
TR200100472T2 (tr) Lipaz inhibitörleri ile sitozan içeren farmasötik bileşimler
BR0207278A (pt) Derivados de ftalazinona-piperidina como inibidores de pde4
DE122010000035I2 (de) Substituierte thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
DE69703201T2 (de) Hydroxyamidinderivate verwendbar als stickoxidsynthese inhibitoren
TR200003384T2 (tr) Arginin türevleri kullanılarak oksazolidinon antibakteriyel maddelerin etkisinin arttırılması
DE69821530D1 (de) Dihydrobenzifurane
NO20061316L (no) Imidazopyndinderivater som induserbare NO-syntaseinhibitorer
PT1080104E (pt) Certos tiois heteroarilo substituidos inibidores da enzima conversora da endotelina
BR9902084A (pt) Heterociclos.
BR0115996A (pt) Sulfamidotienopirimidinas
EA200000628A1 (ru) Ингибиторы металлопротеаз матрикса
BRPI0415034A (pt) derivados de aminopiridina como inibidores de não-sintase induzìveis
BR9912307A (pt) Inibidores fkbp
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
ATE403741T1 (de) 7-alkoxycumarinverbindungen als cytochrom p450- substrate
TR200402470T4 (tr) Aminometil-aril-sikloheksanol-türevlerinin enzimatik rasemat ayırma yöntemi.
TR200000624T2 (tr) Bir enzimin etkinliğinin arttırılması ile ilgili bir yöntem.
DE69703115T2 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
ATE238287T1 (de) 6-azauracilderivate als il-5 inhibitoren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition