ATE403741T1 - 7-alkoxycumarinverbindungen als cytochrom p450- substrate - Google Patents

7-alkoxycumarinverbindungen als cytochrom p450- substrate

Info

Publication number
ATE403741T1
ATE403741T1 AT99923518T AT99923518T ATE403741T1 AT E403741 T1 ATE403741 T1 AT E403741T1 AT 99923518 T AT99923518 T AT 99923518T AT 99923518 T AT99923518 T AT 99923518T AT E403741 T1 ATE403741 T1 AT E403741T1
Authority
AT
Austria
Prior art keywords
cytochrome
substrates
alkoxycumarine
compounds
enzyme
Prior art date
Application number
AT99923518T
Other languages
English (en)
Inventor
Stephen Clarke
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE403741T1 publication Critical patent/ATE403741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99923518T 1998-05-08 1999-04-28 7-alkoxycumarinverbindungen als cytochrom p450- substrate ATE403741T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9810016.7A GB9810016D0 (en) 1998-05-08 1998-05-08 Compounds

Publications (1)

Publication Number Publication Date
ATE403741T1 true ATE403741T1 (de) 2008-08-15

Family

ID=27772877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99923518T ATE403741T1 (de) 1998-05-08 1999-04-28 7-alkoxycumarinverbindungen als cytochrom p450- substrate

Country Status (8)

Country Link
US (1) US6617124B1 (de)
EP (1) EP1075539B1 (de)
JP (1) JP2002514438A (de)
AT (1) ATE403741T1 (de)
DE (1) DE69939257D1 (de)
ES (1) ES2312207T3 (de)
GB (1) GB9810016D0 (de)
WO (1) WO1999058710A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420130B1 (en) 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
US6514687B1 (en) 1998-12-14 2003-02-04 Vertex Pharmaceuticals (San Diego), Llc Optical molecular sensors for cytochrome P450 activity
JP2002532487A (ja) * 1998-12-14 2002-10-02 オーロラ バイオサイエンシーズ コーポレイション シトクロムｐ４５０活性に対する光学分子センサ
US6143492A (en) * 1998-12-14 2000-11-07 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
US6420131B1 (en) 1999-08-19 2002-07-16 Gentest Corporation Use of fluorescein aryl ethers in high throughput cytochrome P450 inhibition assays
US6207404B1 (en) 1999-09-30 2001-03-27 Gentest Corporation Coumarin-based CYP3A fluorescent assay reagents
US7056654B2 (en) * 1999-12-13 2006-06-06 Smithkline Beecham Corporation Screening assay for inhibitors of human cytochrome P-450
WO2001044494A2 (en) * 1999-12-13 2001-06-21 Smithkline Beecham P.L.C. P450 enzyme substrate
AU2001271985A1 (en) * 2000-07-12 2002-01-21 American Home Products Corporation Method for testing for inhibition of drug-metabolizing cytochrome p450 isozymes
JP2022554230A (ja) * 2019-10-25 2022-12-28 クウォク ジェシカ 神経系の状態の処置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE734121A (de) * 1968-06-14 1969-11-17

Also Published As

Publication number Publication date
EP1075539B1 (de) 2008-08-06
ES2312207T3 (es) 2009-02-16
EP1075539A1 (de) 2001-02-14
WO1999058710A1 (en) 1999-11-18
JP2002514438A (ja) 2002-05-21
GB9810016D0 (en) 1998-07-08
US6617124B1 (en) 2003-09-09
DE69939257D1 (de) 2008-09-18

Similar Documents

Publication Publication Date Title
AU3933700A (en) Power supply compensation for noise shaped, digital amplifiers
DE69905582T2 (de) Heterocyclische verbindungen als rotamase-enzymen inhibitoren
JO2654B1 (en) Multiple aryl caroxa amides are useful as lipid - lowering agents
EP1464673A3 (de) Polyanhydride mit biologisch aktiven Degradationsprodukten
MXPA03000136A (es) Derivados anticonvulsivos utiles para prevenir el desarrollo de la diabetes mellitus de tipo ii o del sindromex.
AR006390A1 (es) Derivados de lactama
EA200001129A3 (ru) Способ получения 4-карбоксиамино-2-замещенного-1,2,3,4-тетрагидрохинолина
ATE403741T1 (de) 7-alkoxycumarinverbindungen als cytochrom p450- substrate
DE69832200D1 (de) 2,3-substituierte indolverbindungen als cox-2 inhibitoren
IL138688A0 (en) Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
DE69913705D1 (de) Neue cofaktoren für methyltransferasen
MXPA03003942A (es) Compuestos bis-heterociclicos con actividad antitumoral y quimiosensibilizante.
AU3163100A (en) Benzofuran-2-one
GB9918429D0 (en) Organic compounds
AP2001002045A0 (en) FKBP inhibitors.
AU4156499A (en) Benzenesulphonamide derivatives as pyruvate dehydrogenase activators
DE60104205D1 (de) Enzymsubstrat
GB9902068D0 (en) Compounds
ATE337411T1 (de) Diethoxyfluorescein als indikator für cytochrome p450
NO20041537L (no) Fremgangsmate ved fremstilling av 14beta-hydroksy-baccatin III-1, 14-karbonat
NO20041542L (no) Fremgangsmate ved fremstilling av 14 beta-hydroksy-baccatin III-1,14-karbonat
ATE243698T1 (de) 1,2-dihydro-1-oxo-pyrazino(1,2-)indolederivate
WO2001044494A3 (en) P450 enzyme substrate
ATE264308T1 (de) Aminoalkyl-3,4-dihydrochinolin-derivate als no synthase inhibitoren
AU1783700A (en) 1,8-benzonaphthyridine derivatives

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties