ES2046950B1 - Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. - Google Patents
Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente.Info
- Publication number
- ES2046950B1 ES2046950B1 ES09201189A ES9201189A ES2046950B1 ES 2046950 B1 ES2046950 B1 ES 2046950B1 ES 09201189 A ES09201189 A ES 09201189A ES 9201189 A ES9201189 A ES 9201189A ES 2046950 B1 ES2046950 B1 ES 2046950B1
- Authority
- ES
- Spain
- Prior art keywords
- hydrolysis
- acid
- ester
- propionico
- enantious
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCESO PARA LA PRODUCCION DE ACIDO S-(+)-2-(3-BENZOILFENII, PROPIONICO POR HIDROLISIS ENANTIOSELECTIVA CATALIZADA ENZIMATICAMENTE. UN PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO S-(+)-2-(3-BENZOILFENIL) PROPIONICO (I) POR HIDROLISIS ESTEREOSELECTIVA DEL ENANTIOMERO R DE UN ESTER RACEMICO DEL ACIDO 2-(3-BENZOILFENIL) PROPIONICO, CATALIZADA POR UNA LIPASA. LA HIDROLISIS SE REALIZA EN UNA MEZCLA DE DOS DISOLVENTES ORGANICOS, UNO MAYORITARIO INMISCIBLE EN AGUA Y OTRO (EN PROPORCION DEL 5 AL 25% V/V) QUE ES TOTAL O PARCIALMENTE MISCIBLE EN AGUA, EL CUAL PERMITE SOLUBILIZAR UNA CIERTA CANTIDAD DE AGUA, NO SUPERIOR AL 5% (V/V). LA HIDROLISIS VA SEGUIDA DE UN REPARTO ENTRE UN DISOLVENTE ORGANICO INMISCIBLE EN AGUA Y UN MEDIO ACUOSO ALCALINO, QUEDANDO EN ESTA SEGUNDA FASE EL ESTER REMANENTE DE CONFIGURACION S QUE POSTERIORMENTE SE HIDROLIZA AL ACIDO S-(+)-2-(3-BENZOILFENIL) PROPIONICO EN MEDIO ACUOSO. EL COMPUESTO DEL TITULO ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES TIENE PROPIEDADES ANTIINFLAMATORIAS Y ANALGESICAS. FORMULA
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201189A ES2046950B1 (es) | 1992-06-08 | 1992-06-08 | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
DE69315577T DE69315577D1 (de) | 1992-06-08 | 1993-05-26 | VERFAHREN ZUR HERSTELLUNG VON S-(1)-2-(3-benzoylphenyl)PROPIONSÄURE DURCH ENZYMKATALINIERTE ENANTIOSELEKTIVE HYDROLYSE. |
PCT/EP1993/001321 WO1993025703A1 (en) | 1992-06-08 | 1993-05-26 | A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective hydrolysis |
DE0644949T DE644949T1 (de) | 1992-06-08 | 1993-05-26 | VERFAHREN ZUR HERSTELLUNG VON S-(1)-2-(3-benzoylphenyl)PROPIONSÄURE DURCH ENZYMKATALINIERTE ENANTIOSELEKTIVE HYDROLYSE. |
AT93912795T ATE160820T1 (de) | 1992-06-08 | 1993-05-26 | Verfahren zur herstellung von s-(1)-2-(3- benzoylphenyl)propionsäure durch enzymkatalinierte enantioselektive hydrolyse. |
ES93912795T ES2072837T1 (es) | 1992-06-08 | 1993-05-26 | Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. |
EP93912795A EP0644949B1 (en) | 1992-06-08 | 1993-05-26 | A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective hydrolysis |
AU43181/93A AU4318193A (en) | 1992-06-08 | 1993-05-26 | A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective hydrolysis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201189A ES2046950B1 (es) | 1992-06-08 | 1992-06-08 | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2046950A1 ES2046950A1 (es) | 1994-02-01 |
ES2046950B1 true ES2046950B1 (es) | 1994-10-01 |
Family
ID=8277264
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09201189A Expired - Fee Related ES2046950B1 (es) | 1992-06-08 | 1992-06-08 | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
ES93912795T Pending ES2072837T1 (es) | 1992-06-08 | 1993-05-26 | Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93912795T Pending ES2072837T1 (es) | 1992-06-08 | 1993-05-26 | Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0644949B1 (es) |
AT (1) | ATE160820T1 (es) |
AU (1) | AU4318193A (es) |
DE (2) | DE69315577D1 (es) |
ES (2) | ES2046950B1 (es) |
WO (1) | WO1993025703A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5912164A (en) * | 1993-03-03 | 1999-06-15 | Laboratorios Menarini S.A. | Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis |
GB9304256D0 (en) * | 1993-03-03 | 1993-04-21 | Chiros Ltd | Arylalkanoic acid resolution |
DE10004926A1 (de) | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
US7589233B2 (en) | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
US8173840B2 (en) | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
CN105820107B (zh) | 2007-06-04 | 2022-09-09 | 泰飞尔公司 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途 |
KR20200022525A (ko) | 2008-12-04 | 2020-03-03 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ218717A (en) * | 1985-12-20 | 1989-10-27 | Wisconsin Alumni Res Found | Process for preparing an (s)alpha-methylarylacetic acid from a mixture of (r) and (s)-#a#-methylarylacetic acid esters |
FR2596415B1 (fr) * | 1986-03-26 | 1988-07-01 | Elf Aquitaine | Procede pour l'execution de reactions enzymatiques au sein d'un solvant organique |
US5108916A (en) * | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
JPH05505936A (ja) * | 1990-02-26 | 1993-09-02 | ローヌ ― プーラン インコーポレイテッド | 肝酵素による2―アリールプロピオン酸エステル化合物の加水分解による立体特異的分割 |
-
1992
- 1992-06-08 ES ES09201189A patent/ES2046950B1/es not_active Expired - Fee Related
-
1993
- 1993-05-26 ES ES93912795T patent/ES2072837T1/es active Pending
- 1993-05-26 DE DE69315577T patent/DE69315577D1/de not_active Expired - Lifetime
- 1993-05-26 AU AU43181/93A patent/AU4318193A/en not_active Abandoned
- 1993-05-26 WO PCT/EP1993/001321 patent/WO1993025703A1/en active IP Right Grant
- 1993-05-26 AT AT93912795T patent/ATE160820T1/de not_active IP Right Cessation
- 1993-05-26 DE DE0644949T patent/DE644949T1/de active Pending
- 1993-05-26 EP EP93912795A patent/EP0644949B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU4318193A (en) | 1994-01-04 |
ES2046950A1 (es) | 1994-02-01 |
WO1993025703A1 (en) | 1993-12-23 |
DE69315577D1 (de) | 1998-01-15 |
ATE160820T1 (de) | 1997-12-15 |
EP0644949B1 (en) | 1997-12-03 |
ES2072837T1 (es) | 1995-08-01 |
EP0644949A1 (en) | 1995-03-29 |
DE644949T1 (de) | 1996-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000401 |