ES2046950A1 - Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. - Google Patents
Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente.Info
- Publication number
- ES2046950A1 ES2046950A1 ES929201189A ES9201189A ES2046950A1 ES 2046950 A1 ES2046950 A1 ES 2046950A1 ES 929201189 A ES929201189 A ES 929201189A ES 9201189 A ES9201189 A ES 9201189A ES 2046950 A1 ES2046950 A1 ES 2046950A1
- Authority
- ES
- Spain
- Prior art keywords
- ester
- benzoylphenyl
- preparation
- hydrolysis
- propionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCESO PARA LA PRODUCCION DE ACIDO S-(+)-2-(3-BENZOILFENII, PROPIONICO POR HIDROLISIS ENANTIOSELECTIVA CATALIZADA ENZIMATICAMENTE. UN PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO S-(+)-2-(3-BENZOILFENIL) PROPIONICO (I) POR HIDROLISIS ESTEREOSELECTIVA DEL ENANTIOMERO R DE UN ESTER RACEMICO DEL ACIDO 2-(3-BENZOILFENIL) PROPIONICO, CATALIZADA POR UNA LIPASA. LA HIDROLISIS SE REALIZA EN UNA MEZCLA DE DOS DISOLVENTES ORGANICOS, UNO MAYORITARIO INMISCIBLE EN AGUA Y OTRO (EN PROPORCION DEL 5 AL 25% V/V) QUE ES TOTAL O PARCIALMENTE MISCIBLE EN AGUA, EL CUAL PERMITE SOLUBILIZAR UNA CIERTA CANTIDAD DE AGUA, NO SUPERIOR AL 5% (V/V). LA HIDROLISIS VA SEGUIDA DE UN REPARTO ENTRE UN DISOLVENTE ORGANICO INMISCIBLE EN AGUA Y UN MEDIO ACUOSO ALCALINO, QUEDANDO EN ESTA SEGUNDA FASE EL ESTER REMANENTE DE CONFIGURACION S QUE POSTERIORMENTE SE HIDROLIZA AL ACIDO S-(+)-2-(3-BENZOILFENIL) PROPIONICO EN MEDIO ACUOSO. EL COMPUESTO DEL TITULO ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES TIENE PROPIEDADES ANTIINFLAMATORIAS Y ANALGESICAS. FORMULA
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201189A ES2046950B1 (es) | 1992-06-08 | 1992-06-08 | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
AU43181/93A AU4318193A (en) | 1992-06-08 | 1993-05-26 | A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective hydrolysis |
DE69315577T DE69315577D1 (de) | 1992-06-08 | 1993-05-26 | VERFAHREN ZUR HERSTELLUNG VON S-(1)-2-(3-benzoylphenyl)PROPIONSÄURE DURCH ENZYMKATALINIERTE ENANTIOSELEKTIVE HYDROLYSE. |
DE0644949T DE644949T1 (de) | 1992-06-08 | 1993-05-26 | VERFAHREN ZUR HERSTELLUNG VON S-(1)-2-(3-benzoylphenyl)PROPIONSÄURE DURCH ENZYMKATALINIERTE ENANTIOSELEKTIVE HYDROLYSE. |
EP93912795A EP0644949B1 (en) | 1992-06-08 | 1993-05-26 | A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective hydrolysis |
ES93912795T ES2072837T1 (es) | 1992-06-08 | 1993-05-26 | Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. |
PCT/EP1993/001321 WO1993025703A1 (en) | 1992-06-08 | 1993-05-26 | A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective hydrolysis |
AT93912795T ATE160820T1 (de) | 1992-06-08 | 1993-05-26 | Verfahren zur herstellung von s-(1)-2-(3- benzoylphenyl)propionsäure durch enzymkatalinierte enantioselektive hydrolyse. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201189A ES2046950B1 (es) | 1992-06-08 | 1992-06-08 | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2046950A1 true ES2046950A1 (es) | 1994-02-01 |
ES2046950B1 ES2046950B1 (es) | 1994-10-01 |
Family
ID=8277264
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09201189A Expired - Fee Related ES2046950B1 (es) | 1992-06-08 | 1992-06-08 | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
ES93912795T Pending ES2072837T1 (es) | 1992-06-08 | 1993-05-26 | Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93912795T Pending ES2072837T1 (es) | 1992-06-08 | 1993-05-26 | Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0644949B1 (es) |
AT (1) | ATE160820T1 (es) |
AU (1) | AU4318193A (es) |
DE (2) | DE69315577D1 (es) |
ES (2) | ES2046950B1 (es) |
WO (1) | WO1993025703A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5912164A (en) * | 1993-03-03 | 1999-06-15 | Laboratorios Menarini S.A. | Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis |
GB9304256D0 (en) * | 1993-03-03 | 1993-04-21 | Chiros Ltd | Arylalkanoic acid resolution |
DE10004926A1 (de) | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
US8173840B2 (en) | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
US7589233B2 (en) | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
KR20230085223A (ko) | 2008-12-04 | 2023-06-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0227078A1 (en) * | 1985-12-20 | 1987-07-01 | Wisconsin Alumni Research Foundation | Process for preparing (S)-alpha-methylarylacetic acids |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2596415B1 (fr) * | 1986-03-26 | 1988-07-01 | Elf Aquitaine | Procede pour l'execution de reactions enzymatiques au sein d'un solvant organique |
US5108916A (en) * | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
ATE151813T1 (de) * | 1990-02-26 | 1997-05-15 | Rhone Poulenc Inc | Stereospezifische trennung durch hydrolyse von 2- arylpropionsäureestern mit leberenzymen |
-
1992
- 1992-06-08 ES ES09201189A patent/ES2046950B1/es not_active Expired - Fee Related
-
1993
- 1993-05-26 DE DE69315577T patent/DE69315577D1/de not_active Expired - Lifetime
- 1993-05-26 AT AT93912795T patent/ATE160820T1/de not_active IP Right Cessation
- 1993-05-26 DE DE0644949T patent/DE644949T1/de active Pending
- 1993-05-26 ES ES93912795T patent/ES2072837T1/es active Pending
- 1993-05-26 AU AU43181/93A patent/AU4318193A/en not_active Abandoned
- 1993-05-26 WO PCT/EP1993/001321 patent/WO1993025703A1/en active IP Right Grant
- 1993-05-26 EP EP93912795A patent/EP0644949B1/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0227078A1 (en) * | 1985-12-20 | 1987-07-01 | Wisconsin Alumni Research Foundation | Process for preparing (S)-alpha-methylarylacetic acids |
Non-Patent Citations (2)
Title |
---|
CHEM. PHARM. BULL., Vol. 37, n 10, Octubre 1989, JP; H. AKITA et al.: "Enzymatic hydrolysis in organic solvents for Kinetic resolution of water-insoluble alfa-acyloxy esters with inmobilized lipases", pßg. 2876-2878. * Todo el documento * * |
N.L. ALLINGER et al.: "Química Orgánica", 1986, pág. 743-749, Editorial RevertÚ, S.A., Barcelona, Espa±a. * |
Also Published As
Publication number | Publication date |
---|---|
AU4318193A (en) | 1994-01-04 |
EP0644949A1 (en) | 1995-03-29 |
DE644949T1 (de) | 1996-09-12 |
ES2072837T1 (es) | 1995-08-01 |
ES2046950B1 (es) | 1994-10-01 |
DE69315577D1 (de) | 1998-01-15 |
ATE160820T1 (de) | 1997-12-15 |
EP0644949B1 (en) | 1997-12-03 |
WO1993025703A1 (en) | 1993-12-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000401 |