TR200000900T2 - Ters termal jelasyon özellikleri olan biolojik olarak bozulabilen düşük moleküler ağırlıkta triblok poli(laktid-co-Glikolid)polietilen glikol kopolimerleri - Google Patents
Ters termal jelasyon özellikleri olan biolojik olarak bozulabilen düşük moleküler ağırlıkta triblok poli(laktid-co-Glikolid)polietilen glikol kopolimerleriInfo
- Publication number
- TR200000900T2 TR200000900T2 TR2000/00900T TR200000900T TR200000900T2 TR 200000900 T2 TR200000900 T2 TR 200000900T2 TR 2000/00900 T TR2000/00900 T TR 2000/00900T TR 200000900 T TR200000900 T TR 200000900T TR 200000900 T2 TR200000900 T2 TR 200000900T2
- Authority
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- Prior art keywords
- molecular weight
- low molecular
- glycolide
- lactide
- polyethylene glycol
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
- C08L2666/14—Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
- C08L2666/18—Polyesters or polycarbonates according to C08L67/00 - C08L69/00; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biological Depolymerization Polymers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyethers (AREA)
Abstract
Bu bulus suda çözülebilen düsük moleküle agirlikta, termo-duyarli, biyolojik olarak bozulabilir, hidrofobik bloklardan yüksek bir agirlik yüzdesine sahip olan blok kopolimerleri ve bunlarin parenteral, oküler, topikal, transdermal, vajinal, bukkal, transmukozal, pulmoner, transüretal, rektal, nazal, oral ya da aural ilaç uygulamalarindaki kullanimi ile ilgilidir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/943,167 US6004573A (en) | 1997-10-03 | 1997-10-03 | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US09/164,865 US6117949A (en) | 1998-10-01 | 1998-10-01 | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000900T2 true TR200000900T2 (tr) | 2000-08-21 |
Family
ID=26860926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00900T TR200000900T2 (tr) | 1997-10-03 | 1998-10-02 | Ters termal jelasyon özellikleri olan biolojik olarak bozulabilen düşük moleküler ağırlıkta triblok poli(laktid-co-Glikolid)polietilen glikol kopolimerleri |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1034207B1 (tr) |
JP (3) | JP4656725B2 (tr) |
KR (2) | KR20010030891A (tr) |
CN (1) | CN1195788C (tr) |
AR (1) | AR015175A1 (tr) |
AT (1) | ATE290037T1 (tr) |
AU (1) | AU736812B2 (tr) |
BR (1) | BR9815239B1 (tr) |
CA (1) | CA2305621C (tr) |
DE (1) | DE69829204T2 (tr) |
ES (1) | ES2239408T3 (tr) |
HK (1) | HK1031736A1 (tr) |
IL (2) | IL135415A0 (tr) |
PT (1) | PT1034207E (tr) |
TR (1) | TR200000900T2 (tr) |
WO (1) | WO1999018142A1 (tr) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6201072B1 (en) * | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6841617B2 (en) | 2000-09-28 | 2005-01-11 | Battelle Memorial Institute | Thermogelling biodegradable aqueous polymer solution |
US7087244B2 (en) | 2000-09-28 | 2006-08-08 | Battelle Memorial Institute | Thermogelling oligopeptide polymers |
KR20010053259A (ko) * | 1998-06-30 | 2001-06-25 | 스티븐 엠. 오드레 | 생물학적 활성제의 서방성 수송을 위한, 열에 민감하며생분해가능한 히드로겔 |
WO2001041735A2 (en) * | 1999-12-07 | 2001-06-14 | Amgen Inc. | Thermosensitive biodegradable hydrogels based on low molecular weight pluronics |
US6998137B2 (en) * | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
US7018645B1 (en) * | 2000-04-27 | 2006-03-28 | Macromed, Inc. | Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties |
US6669959B1 (en) * | 2000-07-18 | 2003-12-30 | Aeropharm Technology Incorporated | Modulated release particles for lung delivery |
CN100408099C (zh) * | 2000-11-09 | 2008-08-06 | 阿斯特拉曾尼卡有限公司 | 含有嵌段共聚物的口服药物组合物 |
US20030003074A1 (en) * | 2001-06-14 | 2003-01-02 | Macromed, Inc. | Formulations of lymphokines and method of use thereof for local or both local and systemic control of proliferative cell disorders |
KR100527291B1 (ko) * | 2001-07-14 | 2005-11-09 | 주식회사 삼양사 | 약물 전달체용 양이온기-함유 양친성 블록 공중합체 및그의 음이온성 약물과의 복합체 |
DE60231325D1 (de) * | 2001-11-15 | 2009-04-09 | Biomatera Inc | Verfahren zur herstellung von gelen |
TW200307011A (en) * | 2002-04-18 | 2003-12-01 | Chugai Pharmaceutical Co Ltd | Hyaluronic acid modifier |
FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
MXPA05003659A (es) | 2002-10-31 | 2005-09-20 | Pfizer Prod Inc | Conjugados liquidos de compuestos farmaceuticos solidos. |
FR2855521B1 (fr) | 2003-05-28 | 2005-08-05 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques. |
WO2005003214A1 (ja) | 2003-07-07 | 2005-01-13 | Nof Corporation | 三元ブロック共重合体、その製造法及び生体内適合材料 |
FR2862536B1 (fr) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
FR2862535B1 (fr) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques |
FR2862541B1 (fr) * | 2003-11-21 | 2007-04-20 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques |
TW200538148A (en) * | 2004-01-13 | 2005-12-01 | Vasogenix Pharmaceuticals Inc | Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same |
US7976847B2 (en) | 2004-01-13 | 2011-07-12 | Vasogenix Pharmaceuticals, Inc. | Controlled release CGRP delivery composition for cardiovascular and renal indications |
EP1555278A1 (en) * | 2004-01-15 | 2005-07-20 | Innocore Technologies B.V. | Biodegradable multi-block co-polymers |
AU2005299748B2 (en) * | 2004-10-21 | 2009-04-09 | Tgel Bio Co., Ltd | In situ controlled release drug delivery system |
CA2628580C (en) * | 2005-12-06 | 2014-07-08 | Tyco Healthcare Group Lp | Bioabsorbable compounds and compositions containing them |
DK1983990T3 (da) | 2006-01-26 | 2011-07-11 | Us Gov Health & Human Serv | Allosteriske A3-adenosin-receptormodulatorer |
JP5019851B2 (ja) * | 2006-11-09 | 2012-09-05 | 学校法人 関西大学 | 温度応答性ゾル−ゲル転移を示す生分解性ポリマー及びその製造方法 |
EP2098256B1 (en) * | 2006-11-17 | 2016-06-08 | National Cerebral and Cardiovascular Center | Blood-coagulation inhibiting material, coating material and in vivo indwelling members made by using the material, and method of treatment |
PL2115029T3 (pl) | 2007-02-15 | 2016-01-29 | Tolmar Therapeutics Inc | Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów |
FR2915683B1 (fr) | 2007-05-03 | 2009-08-07 | Flamel Technologies Sa | Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif |
CN101333295B (zh) * | 2007-06-27 | 2011-01-05 | 中国科学院化学研究所 | 一种生物可降解高分子纳米粒子及其专用聚合物和它们的制备方法 |
US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
FR2919188B1 (fr) * | 2007-07-27 | 2010-02-26 | Proteins & Peptides Man | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
US8642062B2 (en) | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
JP4824710B2 (ja) * | 2008-02-08 | 2011-11-30 | 国立清華大学 | グラフト共重合体およびブロック共重合体の多機能混合ミセルならびにその製造方法 |
US8916188B2 (en) | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
JP5814793B2 (ja) * | 2008-11-25 | 2015-11-17 | エコール ポリテクニク フェデラル ド ローザンヌ(エーペーエフエル) | ブロックコポリマーおよびその使用 |
CN102639670B (zh) | 2009-09-18 | 2016-02-17 | 普罗赛瑞克斯医药发展公司 | 具有改进的释放特性的bab三嵌段聚合物 |
EP2382966A1 (en) * | 2010-03-12 | 2011-11-02 | DSM IP Assets B.V. | Micelle compositions and process for the preparation thereof |
JP5950901B2 (ja) * | 2010-03-26 | 2016-07-13 | エボニック コーポレイションEvonik Corporation | 安定剤として生分解性表面活性ブロックコポリマを含むマイクロカプセル化のためのエマルジョン |
CN102058909A (zh) * | 2011-01-18 | 2011-05-18 | 复旦大学 | 聚乙二醇-共聚酯嵌段共聚物防粘连材料及其制备方法与应用 |
CN102181048B (zh) * | 2011-03-11 | 2015-02-25 | 上海谊众生物技术有限公司 | 一种生物医用聚醚/聚酯嵌段共聚物的制备方法 |
CN102218027B (zh) * | 2011-04-22 | 2014-07-02 | 上海谊众生物技术有限公司 | 一种包载难溶性抗肿瘤药物的聚合物胶束冻干制剂 |
EP2596802A1 (en) | 2011-11-23 | 2013-05-29 | PLS-Design GmbH | Pharmaceutical composition for treatment of allergic reactions |
EP2813531B1 (en) * | 2012-02-08 | 2018-11-21 | Toray Industries, Inc. | Stimuli-responsive material and medical material comprising same |
EP2674167A1 (en) | 2012-06-14 | 2013-12-18 | PLS-Design GmbH | Controlled activation of complement components for use as endogenous adjuvant |
EP2674168A1 (en) | 2012-06-14 | 2013-12-18 | PLS-Design GmbH | Modulation of effector T cell responses by local depletion of complement component C3 |
JP6119608B2 (ja) * | 2012-09-24 | 2017-04-26 | 東レ株式会社 | ブロック共重合体の製造方法 |
CN103772686B (zh) * | 2012-10-26 | 2015-01-07 | 苏州雷纳药物研发有限公司 | 一种两亲性嵌段共聚物及其制备方法、以及该共聚物与抗肿瘤药物形成的胶束载药系统 |
EP2746396A1 (en) | 2012-12-20 | 2014-06-25 | PLS-Design GmbH | Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation |
CN103611196B (zh) * | 2013-04-17 | 2015-09-16 | 苏州工业园区汉德医院投资管理有限公司 | 一种pela/bmp-2微球及其制备方法 |
JP6176998B2 (ja) * | 2013-05-13 | 2017-08-09 | 学校法人 関西大学 | 温度応答性生分解性高分子組成物及びその製造方法 |
CN104689380A (zh) * | 2013-12-10 | 2015-06-10 | 复旦大学 | 一种由物理交联水凝胶构成的黏膜下注射材料及其应用 |
CN103819905B (zh) * | 2014-03-07 | 2016-01-20 | 山东理工大学 | 一种用聚三亚甲基碳酸酯与聚乙烯吡咯烷酮对聚肽膜亲水性进行改进的方法 |
EP2918262B1 (en) | 2014-03-10 | 2023-08-09 | PLS-Design GmbH | Induction of antigen-specific tolerance by peripheral phagocytosis |
CN104693431A (zh) * | 2014-12-01 | 2015-06-10 | 周益峰 | 一种三嵌段聚合物及其制备方法和应用 |
CN104606129B (zh) * | 2015-01-21 | 2018-05-04 | 中国人民解放军广州军区武汉总医院 | 罗哌卡因长效注射用温敏凝胶及其制备方法 |
CA2974715C (en) * | 2015-01-27 | 2020-05-05 | The Johns Hopkins University | Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces |
JP6584868B2 (ja) * | 2015-02-25 | 2019-10-02 | 学校法人 関西大学 | ゲル素材及びその製造方法 |
EP3095440B1 (en) | 2015-05-19 | 2020-01-15 | PLS-Design GmbH | Antigen-specific immunotherapy using tolerizing liposomes |
EP3342795B1 (en) * | 2015-08-24 | 2023-01-04 | 3-D Matrix, Ltd. | Biodegradable injectable gel |
CN105878174B (zh) * | 2016-04-26 | 2021-06-29 | 广州帝奇医药技术有限公司 | 一种固体分散体及其制备方法与应用 |
CN106349466B (zh) * | 2016-09-02 | 2019-09-20 | 广东众生药业股份有限公司 | 一种新的生物医用聚醚/聚酯嵌段共聚物的制备方法 |
WO2018183984A1 (en) * | 2017-03-31 | 2018-10-04 | Rowan University | Optically clear, in-situ forming biodegradable nano-carriers for ocular therapy, and methods using same |
EP3615586B1 (en) * | 2017-04-28 | 2021-02-17 | Evonik Operations GmbH | Biodegradable bone glue |
WO2019076478A1 (en) | 2017-10-18 | 2019-04-25 | Luxembourg Institute Of Health (Lih) | OLIGODESOXYNUCLEOTIDES INCORPORATED IN HYDROGEL AS TOLEROGENEOUS ADJUVANT FOR SUB-CUTANEOUS IMMUNOTHERAPY |
WO2019076477A1 (en) | 2017-10-18 | 2019-04-25 | Luxembourg Institute Of Health (Lih) | INDUCTION OF ALLERGEN-SPECIFIC TREGS PRIOR TO ORAL OR SUBLINGUAL IMMUNOTHERAPY OF FOOD ALLERGY |
CN109498804B (zh) * | 2018-12-04 | 2022-07-26 | 中国人民解放军军事科学院军事医学研究院 | 一种温度响应型狂犬疫苗递送系统 |
EP3679928A1 (fr) * | 2019-01-08 | 2020-07-15 | Atlangram | Composition pharmaceutique de type gel pour traiter/prevenir une infection |
CN110669184B (zh) * | 2019-10-16 | 2022-05-31 | 临沂大学 | 一种具有药物释放功能的形状记忆高分子材料的制备方法及所得产品和应用 |
GB202103785D0 (en) * | 2021-03-18 | 2021-05-05 | UCB Biopharma SRL | Formulations |
CN114699566B (zh) * | 2022-04-08 | 2022-12-20 | 海泽临床成果转化医学研究院(无锡)有限公司 | 一种可吸收结扎夹的制备方法 |
CN117547654A (zh) * | 2023-12-04 | 2024-02-13 | 上海长征医院 | 一种仿生负载rhBMP-2骨修复材料及其制备方法与应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0258780B1 (en) * | 1986-09-05 | 1993-06-23 | American Cyanamid Company | Polyesters containing alkylene oxide blocks as drug delivery systems |
US5612052A (en) * | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
KR0180334B1 (ko) * | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
US5702717A (en) * | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
FR2741628B1 (fr) * | 1995-11-29 | 1998-02-06 | Centre Nat Rech Scient | Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs |
CA2299393A1 (en) * | 1997-08-08 | 1999-02-18 | Sung Wan Kim | Injectable biodegradable block copolymer gels for use in drug delivery |
-
1998
- 1998-10-02 JP JP2000514947A patent/JP4656725B2/ja not_active Expired - Fee Related
- 1998-10-02 KR KR1020007003585A patent/KR20010030891A/ko active Search and Examination
- 1998-10-02 CA CA002305621A patent/CA2305621C/en not_active Expired - Lifetime
- 1998-10-02 AT AT98950839T patent/ATE290037T1/de active
- 1998-10-02 EP EP98950839A patent/EP1034207B1/en not_active Expired - Lifetime
- 1998-10-02 ES ES98950839T patent/ES2239408T3/es not_active Expired - Lifetime
- 1998-10-02 AR ARP980104933A patent/AR015175A1/es active IP Right Grant
- 1998-10-02 WO PCT/US1998/020649 patent/WO1999018142A1/en active IP Right Grant
- 1998-10-02 TR TR2000/00900T patent/TR200000900T2/tr unknown
- 1998-10-02 BR BRPI9815239-4A patent/BR9815239B1/pt not_active IP Right Cessation
- 1998-10-02 CN CNB988113112A patent/CN1195788C/zh not_active Expired - Lifetime
- 1998-10-02 AU AU96780/98A patent/AU736812B2/en not_active Expired
- 1998-10-02 KR KR1020007003583A patent/KR100633939B1/ko not_active IP Right Cessation
- 1998-10-02 PT PT98950839T patent/PT1034207E/pt unknown
- 1998-10-02 IL IL13541598A patent/IL135415A0/xx active IP Right Grant
- 1998-10-02 DE DE69829204T patent/DE69829204T2/de not_active Expired - Lifetime
-
2000
- 2000-04-02 IL IL135415A patent/IL135415A/en not_active IP Right Cessation
-
2001
- 2001-03-07 HK HK01101671A patent/HK1031736A1/xx not_active IP Right Cessation
-
2009
- 2009-12-28 JP JP2009297893A patent/JP4903256B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-11 JP JP2011152462A patent/JP2012012606A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE69829204D1 (en) | 2005-04-07 |
AU736812B2 (en) | 2001-08-02 |
ES2239408T3 (es) | 2005-09-16 |
CA2305621C (en) | 2009-01-20 |
KR20010030889A (ko) | 2001-04-16 |
EP1034207A1 (en) | 2000-09-13 |
BR9815239A (pt) | 2001-12-11 |
IL135415A0 (en) | 2001-05-20 |
CN1282345A (zh) | 2001-01-31 |
WO1999018142A1 (en) | 1999-04-15 |
CA2305621A1 (en) | 1999-04-15 |
HK1031736A1 (en) | 2001-06-22 |
ATE290037T1 (de) | 2005-03-15 |
IL135415A (en) | 2008-04-13 |
DE69829204T2 (de) | 2005-12-15 |
PT1034207E (pt) | 2005-07-29 |
EP1034207B1 (en) | 2005-03-02 |
KR100633939B1 (ko) | 2006-10-16 |
JP2002516910A (ja) | 2002-06-11 |
JP4656725B2 (ja) | 2011-03-23 |
JP2010144178A (ja) | 2010-07-01 |
JP2012012606A (ja) | 2012-01-19 |
AU9678098A (en) | 1999-04-27 |
JP4903256B2 (ja) | 2012-03-28 |
EP1034207A4 (en) | 2002-04-17 |
BR9815239B1 (pt) | 2010-07-13 |
KR20010030891A (ko) | 2001-04-16 |
CN1195788C (zh) | 2005-04-06 |
AR015175A1 (es) | 2001-04-18 |
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