TR199903240T2 - Agiz yoluyla proteinlerin verilmesi için yöntem - Google Patents
Agiz yoluyla proteinlerin verilmesi için yöntemInfo
- Publication number
- TR199903240T2 TR199903240T2 TR1999/03240T TR9903240T TR199903240T2 TR 199903240 T2 TR199903240 T2 TR 199903240T2 TR 1999/03240 T TR1999/03240 T TR 1999/03240T TR 9903240 T TR9903240 T TR 9903240T TR 199903240 T2 TR199903240 T2 TR 199903240T2
- Authority
- TR
- Turkey
- Prior art keywords
- oral administration
- proteins
- hydrogel matrix
- composition
- bioactive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Bioaktif bilesenlerinin omurgalilara oral uygulanmasi için bir bilesim ve yöntem tarif edilmektedir. Bu yöntem bir büyüyebilen hidrojel matrisi ve bu hidrojel matris içinde yer alan bir bioaktif bilesimden olusan bir bilesimin omurgaliya oral olarak uygulanmasi adimindan olusur.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4228097P | 1997-04-02 | 1997-04-02 | |
US6136797P | 1997-10-08 | 1997-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199903240T2 true TR199903240T2 (tr) | 2000-05-22 |
Family
ID=26719055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1999/03240T TR199903240T2 (tr) | 1997-04-02 | 1998-04-02 | Agiz yoluyla proteinlerin verilmesi için yöntem |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0975328A1 (tr) |
JP (1) | JP2002512607A (tr) |
KR (1) | KR20010005952A (tr) |
CN (1) | CN1259045A (tr) |
AU (1) | AU727053B2 (tr) |
BR (1) | BR9808466A (tr) |
CA (1) | CA2285457A1 (tr) |
IL (1) | IL132176A0 (tr) |
NO (1) | NO994757L (tr) |
NZ (1) | NZ500075A (tr) |
PL (1) | PL335974A1 (tr) |
TR (1) | TR199903240T2 (tr) |
WO (1) | WO1998043615A1 (tr) |
YU (1) | YU49699A (tr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
DE10040592A1 (de) * | 2000-08-15 | 2002-03-07 | Aventis Res & Tech Gmbh & Co | Formulierung zur verbesserten Aufnahme von Wirkstoffen und deren Verwendung |
US6878384B2 (en) | 2001-03-13 | 2005-04-12 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
CA2479751C (en) | 2002-03-20 | 2008-06-03 | Trent Poole | Inhalation apparatus |
ES2385934T3 (es) | 2004-08-20 | 2012-08-03 | Mannkind Corporation | Catálisis de la síntesis de dicetopiperazina. |
KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
WO2006110448A2 (en) * | 2005-04-07 | 2006-10-19 | Drexel University | Bioactive thermogelling polymer systems and methods of their use |
CN101287443B (zh) | 2005-07-29 | 2013-05-29 | 斯蒂茨廷格罗宁根药物研究中心 | pH控制的脉冲释放系统、其制备方法和用途 |
CA2617226A1 (en) * | 2005-08-01 | 2007-02-08 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
DK1928423T3 (en) | 2005-09-14 | 2016-02-29 | Mannkind Corp | A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces |
US8039431B2 (en) | 2006-02-22 | 2011-10-18 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
KR101443926B1 (ko) | 2006-06-15 | 2014-10-02 | 마이크로벤션, 인코포레이티드 | 팽창성 중합체로 제조된 색전술용 장치 |
EP2231215B1 (en) | 2007-12-21 | 2019-01-30 | MicroVention, Inc. | Hydrogel filaments for biomedical uses |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
AU2009257311B2 (en) | 2008-06-13 | 2014-12-04 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
JP5667095B2 (ja) | 2009-03-11 | 2015-02-12 | マンカインド コーポレイション | 吸入器の抵抗を測定するための装置、システムおよび方法 |
CA2764505C (en) | 2009-06-12 | 2018-09-25 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
HUP0900482A2 (en) | 2009-08-03 | 2011-03-28 | Cera Med Kft | Pharmaceutical formulation for oral administration |
CN102665606A (zh) | 2009-09-24 | 2012-09-12 | 微排放器公司 | 用于生物医学用途的可注射水凝胶线丝 |
US9993252B2 (en) | 2009-10-26 | 2018-06-12 | Microvention, Inc. | Embolization device constructed from expansile polymer |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
RU2571331C1 (ru) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
CN105667994B (zh) | 2011-04-01 | 2018-04-06 | 曼金德公司 | 用于药物药盒的泡罩包装 |
WO2012145431A2 (en) | 2011-04-18 | 2012-10-26 | Microvention, Inc. | Embolic devices |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
WO2013158781A1 (en) | 2012-04-18 | 2013-10-24 | Microvention, Inc. | Embolic devices |
US9802012B2 (en) | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
ES2754388T3 (es) | 2013-03-15 | 2020-04-17 | Mannkind Corp | Composiciones y métodos de dicetopiperazina microcristalina |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
WO2015021044A1 (en) * | 2013-08-05 | 2015-02-12 | University Of Rochester | Compositions and methods for stimuli-responsive release of a therapeutic agent |
EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10124090B2 (en) | 2014-04-03 | 2018-11-13 | Terumo Corporation | Embolic devices |
WO2015167752A1 (en) | 2014-04-29 | 2015-11-05 | Microvention, Inc. | Polymers including active agents |
US10092663B2 (en) | 2014-04-29 | 2018-10-09 | Terumo Corporation | Polymers |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US10265405B2 (en) | 2014-11-18 | 2019-04-23 | Board Of Regents, The University Of Texas System | Polymers for delivery of factor VIII and/or factor IX |
WO2016201250A1 (en) | 2015-06-11 | 2016-12-15 | Microvention, Inc. | Expansile device for implantation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2976576A (en) * | 1956-04-24 | 1961-03-28 | Wichterle Otto | Process for producing shaped articles from three-dimensional hydrophilic high polymers |
US3220960A (en) * | 1960-12-21 | 1965-11-30 | Wichterle Otto | Cross-linked hydrophilic polymers and articles made therefrom |
DE1617393C2 (de) * | 1966-01-06 | 1982-11-11 | Československá akademie věd, Praha | Verfahren zur Herstellung von biologisch aktive Stoffe enthaltenden hydrophilen vernetzten Copolymeren |
US3607848A (en) * | 1967-08-07 | 1971-09-21 | Ceskoslovenska Akademie Ved | Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters |
US3885078A (en) * | 1968-03-06 | 1975-05-20 | Ceskoslovenska Akademie Ved | Hydrogel laminates and method of manufacturing thereof |
US4071508A (en) * | 1975-02-11 | 1978-01-31 | Plastomedical Sciences, Inc. | Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates |
FR2601026B1 (fr) * | 1986-04-15 | 1988-09-16 | Rhone Poulenc Chimie | Matiere seche hydratable en un gel aqueux contenant des particules de polymeres dispersees, procede pour sa preparation et son application en biologie |
-
1998
- 1998-04-02 CA CA002285457A patent/CA2285457A1/en not_active Abandoned
- 1998-04-02 NZ NZ500075A patent/NZ500075A/xx unknown
- 1998-04-02 JP JP54201598A patent/JP2002512607A/ja active Pending
- 1998-04-02 EP EP98914454A patent/EP0975328A1/en not_active Withdrawn
- 1998-04-02 TR TR1999/03240T patent/TR199903240T2/tr unknown
- 1998-04-02 PL PL98335974A patent/PL335974A1/xx unknown
- 1998-04-02 IL IL13217698A patent/IL132176A0/xx unknown
- 1998-04-02 YU YU49699A patent/YU49699A/sh unknown
- 1998-04-02 WO PCT/US1998/006563 patent/WO1998043615A1/en not_active Application Discontinuation
- 1998-04-02 KR KR1019997009029A patent/KR20010005952A/ko not_active Application Discontinuation
- 1998-04-02 CN CN98805351A patent/CN1259045A/zh active Pending
- 1998-04-02 AU AU68809/98A patent/AU727053B2/en not_active Ceased
- 1998-04-02 BR BR9808466-6A patent/BR9808466A/pt not_active IP Right Cessation
-
1999
- 1999-09-30 NO NO994757A patent/NO994757L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2285457A1 (en) | 1998-10-08 |
AU727053B2 (en) | 2000-11-30 |
NZ500075A (en) | 2001-03-30 |
JP2002512607A (ja) | 2002-04-23 |
EP0975328A1 (en) | 2000-02-02 |
BR9808466A (pt) | 2001-08-07 |
IL132176A0 (en) | 2001-03-19 |
YU49699A (sh) | 2002-12-10 |
AU6880998A (en) | 1998-10-22 |
PL335974A1 (en) | 2000-06-05 |
NO994757L (no) | 1999-11-29 |
NO994757D0 (no) | 1999-09-30 |
CN1259045A (zh) | 2000-07-05 |
KR20010005952A (ko) | 2001-01-15 |
WO1998043615A1 (en) | 1998-10-08 |
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