NZ500075A - Method for the oral delivery of a protein encapsulated within a hydrogel matrix - Google Patents

Method for the oral delivery of a protein encapsulated within a hydrogel matrix

Info

Publication number
NZ500075A
NZ500075A NZ500075A NZ50007598A NZ500075A NZ 500075 A NZ500075 A NZ 500075A NZ 500075 A NZ500075 A NZ 500075A NZ 50007598 A NZ50007598 A NZ 50007598A NZ 500075 A NZ500075 A NZ 500075A
Authority
NZ
New Zealand
Prior art keywords
hydrogel matrix
oral delivery
protein encapsulated
protein
oral administration
Prior art date
Application number
NZ500075A
Inventor
Nicholas A Peppas
Anthony M Lowman
Tsuneji Nagai
Mariko Morishita
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of NZ500075A publication Critical patent/NZ500075A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A pharmaceutical composition for oral administration which comprises a swellable hydrogel matrix and a labile protein contained therein. The hydrogel matrix comprises a crosslinked co-polymer of methacrylic acid and poly(alkylene glycol) monomethacrylate. Also described is a method of administering a therapeutically effective amount of a protein to a non-human vertebrate which comprises orally administering the abovementioned composition. Further described is the use of the abovementioned composition in the preparation of a pharmaceutical composition formulated for oral administration.
NZ500075A 1997-04-02 1998-04-02 Method for the oral delivery of a protein encapsulated within a hydrogel matrix NZ500075A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US6136797P 1997-10-08 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
NZ500075A true NZ500075A (en) 2001-03-30

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ500075A NZ500075A (en) 1997-04-02 1998-04-02 Method for the oral delivery of a protein encapsulated within a hydrogel matrix

Country Status (14)

Country Link
EP (1) EP0975328A1 (en)
JP (1) JP2002512607A (en)
KR (1) KR20010005952A (en)
CN (1) CN1259045A (en)
AU (1) AU727053B2 (en)
BR (1) BR9808466A (en)
CA (1) CA2285457A1 (en)
IL (1) IL132176A0 (en)
NO (1) NO994757L (en)
NZ (1) NZ500075A (en)
PL (1) PL335974A1 (en)
TR (1) TR199903240T2 (en)
WO (1) WO1998043615A1 (en)
YU (1) YU49699A (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE10040592A1 (en) * 2000-08-15 2002-03-07 Aventis Res & Tech Gmbh & Co Composition for oral administration of drugs, e.g. peptidomimetics or sparingly soluble antibiotics, containing hydrogel copolymer of unsaturated acid and polyalkylene glycol ester as resorption improver
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
ATE385193T1 (en) 2002-03-20 2008-02-15 Mannkind Corp INHALATION DEVICE
CA2575692C (en) 2004-08-20 2014-10-14 Mannkind Corporation Catalysis of diketopiperazine synthesis
BR122019022692B1 (en) 2004-08-23 2023-01-10 Mannkind Corporation THERAPEUTIC DRY POWDER COMPOSITION CONTAINING DICETOPIPERAZINE, AT LEAST ONE TYPE OF CATION AND ONE BIOLOGICALLY ACTIVE AGENT
WO2006110448A2 (en) * 2005-04-07 2006-10-19 Drexel University Bioactive thermogelling polymer systems and methods of their use
DK1916995T4 (en) 2005-07-29 2022-10-03 Stichting Groningen Centre For Drug Res PH-CONTROLLED, PULSABLE DELIVERY SYSTEM, METHODS OF MANUFACTURE AND USE THEREOF
CA2617226A1 (en) * 2005-08-01 2007-02-08 Mannkind Corporation Method of preserving the function of insulin-producing cells
DK1937219T3 (en) 2005-09-14 2016-02-15 Mannkind Corp A method for drug formulation based on increasing the affinity of the crystalline surfaces of the microparticle of active principles
IN2015DN00888A (en) 2006-02-22 2015-07-10 Mannkind Corp
CA2655026C (en) 2006-06-15 2016-08-02 Microvention, Inc. Embolization device constructed from expansible polymer
EP2266639B1 (en) 2007-12-21 2016-10-05 MicroVention, Inc. Methods for preparing hydrogel filaments for biomedical use
KR101933816B1 (en) 2008-06-13 2019-03-29 맨카인드 코포레이션 A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI532497B (en) 2008-08-11 2016-05-11 曼凱公司 Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
EP2480166B1 (en) 2009-09-24 2017-11-29 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
US9993252B2 (en) 2009-10-26 2018-06-12 Microvention, Inc. Embolization device constructed from expansile polymer
JP5784622B2 (en) 2009-11-03 2015-09-24 マンカインド コーポレ−ション Apparatus and method for simulating inhalation activity
RU2531455C2 (en) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Systems and methods for dry powder drugs delivery
JP6133270B2 (en) 2011-04-01 2017-05-24 マンカインド コーポレイション Blister packaging for drug cartridge
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
ES2624294T3 (en) 2012-07-12 2017-07-13 Mannkind Corporation Dry powder drug delivery systems
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
EP2970149B1 (en) 2013-03-15 2019-08-21 MannKind Corporation Microcrystalline diketopiperazine compositions and methods
BR112016000937A8 (en) 2013-07-18 2021-06-22 Mannkind Corp dry powder pharmaceutical formulations, method for making a dry powder formulation and use of a dry powder pharmaceutical formulation
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
JP6599361B2 (en) 2014-04-29 2019-10-30 マイクロベンション インコーポレイテッド Polymer containing an active agent
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2024130101A1 (en) * 2022-12-16 2024-06-20 Wake Forest University Health Sciences Hydrogel compositions and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
IT1050353B (en) * 1966-01-06 1981-03-10 Ceskoslovenska Akademie Ved SUPPORTS FOR BIOLOGICALLY ACTIVE SUBSTANCES
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (en) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie DRY MATERIAL MOISTURIZABLE IN AN AQUEOUS GEL CONTAINING PARTICLES OF DISPERSE POLYMERS, METHOD FOR ITS PREPARATION AND ITS APPLICATION IN BIOLOGY

Also Published As

Publication number Publication date
CA2285457A1 (en) 1998-10-08
JP2002512607A (en) 2002-04-23
AU6880998A (en) 1998-10-22
NO994757D0 (en) 1999-09-30
EP0975328A1 (en) 2000-02-02
IL132176A0 (en) 2001-03-19
KR20010005952A (en) 2001-01-15
TR199903240T2 (en) 2000-05-22
PL335974A1 (en) 2000-06-05
YU49699A (en) 2002-12-10
BR9808466A (en) 2001-08-07
NO994757L (en) 1999-11-29
AU727053B2 (en) 2000-11-30
CN1259045A (en) 2000-07-05
WO1998043615A1 (en) 1998-10-08

Similar Documents

Publication Publication Date Title
NZ500075A (en) Method for the oral delivery of a protein encapsulated within a hydrogel matrix
ES2569949T3 (en) Pharmaceutical formulations comprising a peptide complexed with a diketopiperazine
NZ508037A (en) A stabilized antihistamine syrup containing aminopolycarboxylic acid as stabilizer
ATE131039T1 (en) MEDICINAL GEL FORM IN A DISPENSER.
BR9406363A (en) Pharmaceutical composition process for the preparation of the same use and process for the treatment of diseases related to gastric acid
DK372786D0 (en) PHARMACEUTICAL PREPARATIONS OF PHENINDAMINE
MY109512A (en) Pharmaceutical composition
DK0949907T3 (en) Methods and compositions for improved bioavailability and biologically active agents for mucosal administration
AR002355A1 (en) COMPOSITIONS AND METHODS FOR LOCAL ADMINISTRATION OF PHARMACEUTICALLY ACTIVE AGENTS.
CA2276183A1 (en) Pharmaceutical preparations of glutathione and methods of administration thereof
RU2000112650A (en) REGULATED PROGESTIN THERAPY
IL117356A (en) Controlled release matrix and pharmaceutical compositions for oral administration containing it
EP0783299A4 (en) Compounds and compositions for delivering active agents
CA2326198A1 (en) Cosolvent formulations
DE69133623D1 (en) HOLDING NEW PHARMACEUTICAL FORMULATIONS AND PROCESS FOR THEIR PREPARATION
KR850700213A (en) Acetaminophen Gelatin Capsule
NZ237930A (en) Wafer for administration of medicaments through the sub-lingual mucosa
IL78061A (en) Pharmaceutical compositions based on simethicone and guar gum for protection of the oesogastroduodenal mucous membrane
FI963394A (en) Anti-cough composition containing anti-cough agent and benzydamine
ES2095183A1 (en) Gelling aqueous compositions for intranasal administration of drugs.
Kellaway et al. Oral mucosal drug delivery
DK0524696T3 (en) Oral preparations containing dapiprazole
HUP9904320A3 (en) Pharmaceutical compositions of weak acid drugs for colonic delivery
CA2259270A1 (en) Pharmaceutical preparation containing nimesulide for oral administration
NZ500640A (en) A method of preventing pregnancy using a composition of a condensation polymer of an aldehyde and an aromatic sulphonic acid

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)