BR9808466A - Method for oral protein distribution - Google Patents

Method for oral protein distribution

Info

Publication number
BR9808466A
BR9808466A BR9808466-6A BR9808466A BR9808466A BR 9808466 A BR9808466 A BR 9808466A BR 9808466 A BR9808466 A BR 9808466A BR 9808466 A BR9808466 A BR 9808466A
Authority
BR
Brazil
Prior art keywords
protein distribution
composition
oral protein
oral
hydrogel matrix
Prior art date
Application number
BR9808466-6A
Other languages
Portuguese (pt)
Inventor
Nicholas A Peppas
Anthony M Lowman
Tsuneji Nagai
Mariko Morishita
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of BR9808466A publication Critical patent/BR9808466A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"MéTODO PARA DISTRIBUIçãO ORAL DE PROTEìNAS" A presente invenção refere-se a uma composição e método para a administração oral de componentes bioativos a vertebrados. O método compreende a etapa de administrar oralmente ao vertebrado uma composição que compreende uma matriz de hidrogel intumescível e uma composição bioativa contida dentro de matriz de hidrogel."METHOD FOR ORAL DISTRIBUTION OF PROTEINS" The present invention relates to a composition and method for the oral administration of bioactive components to vertebrates. The method comprises the step of orally administering to the vertebrate a composition comprising an intumescible hydrogel matrix and a bioactive composition contained within the hydrogel matrix.

BR9808466-6A 1997-04-02 1998-04-02 Method for oral protein distribution BR9808466A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US6136797P 1997-10-08 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
BR9808466A true BR9808466A (en) 2001-08-07

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808466-6A BR9808466A (en) 1997-04-02 1998-04-02 Method for oral protein distribution

Country Status (14)

Country Link
EP (1) EP0975328A1 (en)
JP (1) JP2002512607A (en)
KR (1) KR20010005952A (en)
CN (1) CN1259045A (en)
AU (1) AU727053B2 (en)
BR (1) BR9808466A (en)
CA (1) CA2285457A1 (en)
IL (1) IL132176A0 (en)
NO (1) NO994757L (en)
NZ (1) NZ500075A (en)
PL (1) PL335974A1 (en)
TR (1) TR199903240T2 (en)
WO (1) WO1998043615A1 (en)
YU (1) YU49699A (en)

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US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
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JP5078014B2 (en) 2004-08-20 2012-11-21 マンカインド コーポレイション Catalytic reaction of diketopiperazine synthesis.
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diketopiperazine salts for drug delivery
WO2006110448A2 (en) * 2005-04-07 2006-10-19 Drexel University Bioactive thermogelling polymer systems and methods of their use
JP2009502908A (en) 2005-07-29 2009-01-29 スティッチング グロニンゲン セントル フォー ドラッグ リサーチ pH-controlled pulse delivery system, preparation and use thereof
ES2439455T3 (en) * 2005-08-01 2014-01-23 Mannkind Corporation Procedure of preserving the function of insulin producing cells
EP1928423B1 (en) 2005-09-14 2015-12-09 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US8377091B2 (en) 2006-06-15 2013-02-19 Microvention, Inc. Embolization device constructed from expansile polymer
EP2266639B1 (en) 2007-12-21 2016-10-05 MicroVention, Inc. Methods for preparing hydrogel filaments for biomedical use
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101558026B1 (en) 2008-06-13 2015-10-06 맨카인드 코포레이션 A dry powder inhaler and system for drug delivery
CA2728523C (en) 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (en) 2008-08-11 2018-02-11 曼凱公司 Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP2440184B1 (en) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
WO2011038291A1 (en) 2009-09-24 2011-03-31 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
KR101745748B1 (en) 2009-10-26 2017-06-12 마이크로벤션, 인코포레이티드 Embolization device constructed from expansile polymer
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
CA2801936C (en) 2010-06-21 2021-06-01 Mannkind Corporation Dry powder drug delivery system and methods
KR101940832B1 (en) 2011-04-01 2019-01-21 맨카인드 코포레이션 Blister package for pharmaceutical cartridges
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (en) 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
BR122019026637B1 (en) 2013-07-18 2023-09-26 Mannkind Corporation PHARMACEUTICAL DRY POWDER FORMULATIONS AND METHOD FOR MANUFACTURING A DRY POWDER FORMULATION
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
JP6599361B2 (en) 2014-04-29 2019-10-30 マイクロベンション インコーポレイテッド Polymer containing an active agent
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation

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US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
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Also Published As

Publication number Publication date
NZ500075A (en) 2001-03-30
CA2285457A1 (en) 1998-10-08
KR20010005952A (en) 2001-01-15
CN1259045A (en) 2000-07-05
TR199903240T2 (en) 2000-05-22
NO994757D0 (en) 1999-09-30
PL335974A1 (en) 2000-06-05
IL132176A0 (en) 2001-03-19
WO1998043615A1 (en) 1998-10-08
NO994757L (en) 1999-11-29
JP2002512607A (en) 2002-04-23
AU6880998A (en) 1998-10-22
YU49699A (en) 2002-12-10
EP0975328A1 (en) 2000-02-02
AU727053B2 (en) 2000-11-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007.