IL132176A0 - Method for oral delivery of proteins - Google Patents

Method for oral delivery of proteins

Info

Publication number
IL132176A0
IL132176A0 IL13217698A IL13217698A IL132176A0 IL 132176 A0 IL132176 A0 IL 132176A0 IL 13217698 A IL13217698 A IL 13217698A IL 13217698 A IL13217698 A IL 13217698A IL 132176 A0 IL132176 A0 IL 132176A0
Authority
IL
Israel
Prior art keywords
proteins
oral delivery
oral
delivery
Prior art date
Application number
IL13217698A
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of IL132176A0 publication Critical patent/IL132176A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
IL13217698A 1997-04-02 1998-04-02 Method for oral delivery of proteins IL132176A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US6136797P 1997-10-08 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
IL132176A0 true IL132176A0 (en) 2001-03-19

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13217698A IL132176A0 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Country Status (14)

Country Link
EP (1) EP0975328A1 (en)
JP (1) JP2002512607A (en)
KR (1) KR20010005952A (en)
CN (1) CN1259045A (en)
AU (1) AU727053B2 (en)
BR (1) BR9808466A (en)
CA (1) CA2285457A1 (en)
IL (1) IL132176A0 (en)
NO (1) NO994757L (en)
NZ (1) NZ500075A (en)
PL (1) PL335974A1 (en)
TR (1) TR199903240T2 (en)
WO (1) WO1998043615A1 (en)
YU (1) YU49699A (en)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE10040592A1 (en) * 2000-08-15 2002-03-07 Aventis Res & Tech Gmbh & Co Composition for oral administration of drugs, e.g. peptidomimetics or sparingly soluble antibiotics, containing hydrogel copolymer of unsaturated acid and polyalkylene glycol ester as resorption improver
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
ES2425392T3 (en) 2002-03-20 2013-10-15 Mannkind Corporation Cartridge for an inhalation device
CN101010305B (en) 2004-08-20 2010-08-11 曼金德公司 Catalysis of diketopiperazine synthesis
KR101644250B1 (en) 2004-08-23 2016-07-29 맨카인드 코포레이션 Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery
US8110212B2 (en) 2005-04-07 2012-02-07 Drexel University Bioactive thermogelling polymer systems and methods of their use
AU2005334837B2 (en) 2005-07-29 2012-07-19 Stichting Groningen Centre For Drug Research PH-controlled pulsatile delivery system, methods for preparation and use thereof
BRPI0614489A2 (en) * 2005-08-01 2011-03-29 Mannkind Corp method for preserving the function of insulin producing cells
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
DK1986679T3 (en) 2006-02-22 2017-11-20 Mannkind Corp PROCEDURE FOR IMPROVING THE PHARMACEUTICAL PROPERTIES OF MICROPARTICLES INCLUDING DICETOPIPERAZINE AND AN ACTIVE INGREDIENT
WO2007147145A2 (en) 2006-06-15 2007-12-21 Microvention, Inc. Embolization device constructed from expansible polymer
CA2709379C (en) 2007-12-21 2016-08-16 Microvention, Inc. Hydrogel filaments for biomedical uses
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA2728230C (en) 2008-06-13 2017-10-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
AU2009259883B2 (en) 2008-06-20 2015-02-05 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI494123B (en) 2008-08-11 2015-08-01 Mannkind Corp Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
SG176738A1 (en) 2009-06-12 2012-01-30 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
JP2013505791A (en) 2009-09-24 2013-02-21 マイクロベンション インコーポレイテッド Injectable hydrogel fiber for medical use
WO2011053555A1 (en) 2009-10-26 2011-05-05 Microvention, Inc. Embolization device constructed from expansile polymer
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2582421A1 (en) 2010-06-21 2013-04-24 MannKind Corporation Dry powder drug delivery system and methods
ES2625858T3 (en) 2011-04-01 2017-07-20 Mannkind Corporation Blister pack for pharmaceutical cartridges
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
WO2014012069A2 (en) 2012-07-12 2014-01-16 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
BR112016000937A8 (en) 2013-07-18 2021-06-22 Mannkind Corp dry powder pharmaceutical formulations, method for making a dry powder formulation and use of a dry powder pharmaceutical formulation
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
CN106456836B (en) 2014-04-29 2019-12-06 微仙美国有限公司 Polymers comprising active agents
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
IT1050353B (en) * 1966-01-06 1981-03-10 Ceskoslovenska Akademie Ved SUPPORTS FOR BIOLOGICALLY ACTIVE SUBSTANCES
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (en) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie DRY MATERIAL MOISTURIZABLE IN AN AQUEOUS GEL CONTAINING PARTICLES OF DISPERSE POLYMERS, METHOD FOR ITS PREPARATION AND ITS APPLICATION IN BIOLOGY

Also Published As

Publication number Publication date
KR20010005952A (en) 2001-01-15
JP2002512607A (en) 2002-04-23
CN1259045A (en) 2000-07-05
AU727053B2 (en) 2000-11-30
EP0975328A1 (en) 2000-02-02
AU6880998A (en) 1998-10-22
NO994757D0 (en) 1999-09-30
BR9808466A (en) 2001-08-07
CA2285457A1 (en) 1998-10-08
NZ500075A (en) 2001-03-30
YU49699A (en) 2002-12-10
PL335974A1 (en) 2000-06-05
WO1998043615A1 (en) 1998-10-08
NO994757L (en) 1999-11-29
TR199903240T2 (en) 2000-05-22

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