TR199901674T2 - - Google Patents

Info

Publication number
TR199901674T2
TR199901674T2 TR1999/01674T TR9901674T TR199901674T2 TR 199901674 T2 TR199901674 T2 TR 199901674T2 TR 1999/01674 T TR1999/01674 T TR 1999/01674T TR 9901674 T TR9901674 T TR 9901674T TR 199901674 T2 TR199901674 T2 TR 199901674T2
Authority
TR
Turkey
Prior art keywords
compound
fluorobenzylamino
ethoxycarbonyl
amino
preparing
Prior art date
Application number
TR1999/01674T
Other languages
English (en)
Turkish (tr)
Inventor
Meisel Peter
Landgraf Karl-Friedrich
Schafer Jurgen
Thiel Wilfried
Rischer Matthias
Olbrich Alfred
Kutscher Bernhard
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of TR199901674T2 publication Critical patent/TR199901674T2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
TR1999/01674T 1997-01-20 1998-01-09 TR199901674T2 (cg-RX-API-DMAC7.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19701694A DE19701694A1 (de) 1997-01-20 1997-01-20 Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
TR199901674T2 true TR199901674T2 (cg-RX-API-DMAC7.html) 1999-10-21

Family

ID=7817756

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01674T TR199901674T2 (cg-RX-API-DMAC7.html) 1997-01-20 1998-01-09

Country Status (30)

Country Link
US (2) US5914425A (cg-RX-API-DMAC7.html)
EP (1) EP0956281B1 (cg-RX-API-DMAC7.html)
JP (1) JP4138886B2 (cg-RX-API-DMAC7.html)
CN (1) CN1125812C (cg-RX-API-DMAC7.html)
AR (1) AR015349A1 (cg-RX-API-DMAC7.html)
AT (1) ATE222235T1 (cg-RX-API-DMAC7.html)
AU (1) AU730776B2 (cg-RX-API-DMAC7.html)
BG (1) BG63893B1 (cg-RX-API-DMAC7.html)
BR (1) BR9806784A (cg-RX-API-DMAC7.html)
CA (3) CA2632585C (cg-RX-API-DMAC7.html)
CZ (1) CZ301778B6 (cg-RX-API-DMAC7.html)
DE (2) DE19701694A1 (cg-RX-API-DMAC7.html)
DK (1) DK0956281T3 (cg-RX-API-DMAC7.html)
EG (1) EG21239A (cg-RX-API-DMAC7.html)
ES (1) ES2178152T3 (cg-RX-API-DMAC7.html)
HU (1) HU227625B1 (cg-RX-API-DMAC7.html)
ID (1) ID22645A (cg-RX-API-DMAC7.html)
IL (1) IL130384A (cg-RX-API-DMAC7.html)
IS (1) IS2115B (cg-RX-API-DMAC7.html)
NO (2) NO311642B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ336205A (cg-RX-API-DMAC7.html)
PL (1) PL195956B1 (cg-RX-API-DMAC7.html)
PT (1) PT956281E (cg-RX-API-DMAC7.html)
RU (1) RU2186765C2 (cg-RX-API-DMAC7.html)
SK (1) SK285303B6 (cg-RX-API-DMAC7.html)
TR (1) TR199901674T2 (cg-RX-API-DMAC7.html)
TW (1) TW531527B (cg-RX-API-DMAC7.html)
UA (1) UA63937C2 (cg-RX-API-DMAC7.html)
WO (1) WO1998031663A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA98319B (cg-RX-API-DMAC7.html)

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TWI287984B (en) 2000-10-17 2007-10-11 Wyeth Corp Pharmaceutical composition for modulating bladder function
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
AR033095A1 (es) * 2001-04-04 2003-12-03 Wyeth Corp Metodos para el tratamiento de motilidad gastrica hiperactiva
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
PL2061465T3 (pl) * 2006-08-23 2014-03-31 Valeant Pharmaceuticals Int Pochodne 4-(N-azacykloalkilo) anilidów jako modulatory kanałów potasowych
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
ATE538084T1 (de) * 2006-11-28 2012-01-15 Valeant Pharmaceuticals Int Bicyclische 1,4-retigabin-analoga als kaliumkanalhemmer
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US20100323015A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
WO2010009433A1 (en) * 2008-07-18 2010-01-21 Valeant Pharmaceuticals International Modified release formulation and methods of use
US20100323016A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
DE102009013613A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Trockenverarbeitung von Retigabin
DE102009013611A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Festes Retigabin in nicht-kristalliner Form
DE102009013612A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Retigabin-Tabletten, bevorzugt mit modifizierter Freisetzung
WO2011039369A2 (en) 2009-10-02 2011-04-07 Medichem S.A. Amorphous forms of a 2-amino-4-(4-fluorobenzylamino)phenylcarbamate derivative
CN102802615A (zh) 2010-01-20 2012-11-28 葛兰素集团有限公司 新瑞替加滨组合物
WO2011101456A2 (en) * 2010-02-19 2011-08-25 Medichem S.A. Stabilized phenylcarbamate derivative in solid state
CN202095728U (zh) 2010-10-29 2012-01-04 假日集团控股有限公司 行李箱把手
CN102464233A (zh) * 2010-11-18 2012-05-23 江苏邦威机械制造有限公司 一种卧式差速缠丝机用应力发生装置
US9102593B2 (en) 2011-01-18 2015-08-11 Glaxo Group Limited Process for the preparation of retigabine
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
WO2013008250A2 (en) * 2011-07-01 2013-01-17 Dr.Reddys Laboratories Limited. Crystalline form of retigabine and processes for mixture of retigabine crystalline modifications
WO2013011518A1 (en) 2011-07-21 2013-01-24 Arch Pharmalabs Limited Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof
USD696019S1 (en) 2011-10-21 2013-12-24 Travelpro International Inc. Handle for luggage
CN102531966B (zh) * 2011-12-23 2013-07-24 山东创新药物研发有限公司 瑞替加滨的晶型d及其制备方法
WO2013114379A1 (en) * 2012-01-30 2013-08-08 Symed Labs Limited Novel polymorphs of n-[2-amino-4-(4-fluorobenzylamino)-phenyl] carbamic acid ethyl ester and processes thereof
CN103373941B (zh) * 2012-04-11 2016-08-17 浙江九洲药物科技有限公司 瑞替加滨及其中间体的制备方法
WO2013179298A2 (en) * 2012-04-23 2013-12-05 Cadila Healthcare Limited A process for preparation of phenyl carbamate derivative and polymorphic forms thereof
WO2014023270A1 (en) 2012-08-09 2014-02-13 Zentiva, K.S. Salts or co-crystals of ethyl n-[2-amino-4-[(4-fluorophenyl)methylamino]-phenyl]carbamate
CN102964273B (zh) * 2012-12-06 2014-04-02 北京英科博雅科技有限公司 瑞替加滨的新晶型f及其制备方法
USD773819S1 (en) 2015-05-27 2016-12-13 Travelpro Products, Inc. Handle for luggage
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
CN114667146A (zh) 2019-11-08 2022-06-24 泽农医药公司 治疗抑郁症的方法
MX2023009314A (es) 2021-02-09 2023-08-16 Xenon Pharmaceuticals Inc Apertura del canal de potasio dependiente de voltaje para usarse en el tratamiento de la anhedonia.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3917113A1 (de) * 1989-05-26 1990-11-29 Schwarzkopf Gmbh Hans Verfahren zur selektiven herstellung von n(pfeil hoch)4(pfeil hoch)-substituierten 1,4-diamino-2-nitrobenzolen
GB8921792D0 (en) * 1989-09-27 1989-11-08 May & Baker Ltd New compositions of matter
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung

Also Published As

Publication number Publication date
CN1125812C (zh) 2003-10-29
IL130384A (en) 2003-02-12
ATE222235T1 (de) 2002-08-15
ES2178152T3 (es) 2002-12-16
WO1998031663A1 (de) 1998-07-23
AU730776B2 (en) 2001-03-15
NZ336205A (en) 2000-01-28
UA63937C2 (uk) 2004-02-16
HUP0000944A2 (hu) 2000-09-28
CA2278201A1 (en) 1998-07-23
EG21239A (en) 2001-03-31
DK0956281T3 (da) 2002-11-04
DE59805186D1 (de) 2002-09-19
JP4138886B2 (ja) 2008-08-27
NO993452D0 (no) 1999-07-13
IS5098A (is) 1999-06-29
SK285303B6 (sk) 2006-10-05
ZA98319B (en) 1998-05-07
DE19701694A1 (de) 1998-07-23
CZ250899A3 (cs) 1999-11-17
CN1243506A (zh) 2000-02-02
NO2011017I1 (no) 2011-09-26
BG63893B1 (bg) 2003-05-30
EP0956281B1 (de) 2002-08-14
NO993452L (no) 1999-07-13
PL335647A1 (en) 2000-05-08
PT956281E (pt) 2002-12-31
HUP0000944A3 (en) 2000-10-30
US6538151B1 (en) 2003-03-25
CZ301778B6 (cs) 2010-06-23
US5914425A (en) 1999-06-22
TW531527B (en) 2003-05-11
IL130384A0 (en) 2000-06-01
PL195956B1 (pl) 2007-11-30
AU6208198A (en) 1998-08-07
JP2001508077A (ja) 2001-06-19
ID22645A (id) 1999-12-02
CA2634811C (en) 2012-11-20
CA2632585C (en) 2010-08-24
HU227625B1 (en) 2011-09-28
EP0956281A1 (de) 1999-11-17
NO2011017I2 (no) 2013-04-02
CA2632585A1 (en) 1998-07-23
HK1024230A1 (en) 2000-10-05
NO311642B1 (no) 2001-12-27
RU2186765C2 (ru) 2002-08-10
AR015349A1 (es) 2001-05-02
SK95699A3 (en) 2000-03-13
BR9806784A (pt) 2000-05-02
BG103657A (en) 2000-02-29
CA2278201C (en) 2009-06-16
CA2634811A1 (en) 1998-07-23
IS2115B (is) 2006-06-15

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