DK0956281T3 - Hidtil ukendte modifikationer af 2-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzen, såvel som fremgangsmåder til deres fremstilling - Google Patents

Hidtil ukendte modifikationer af 2-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzen, såvel som fremgangsmåder til deres fremstilling

Info

Publication number
DK0956281T3
DK0956281T3 DK98904048T DK98904048T DK0956281T3 DK 0956281 T3 DK0956281 T3 DK 0956281T3 DK 98904048 T DK98904048 T DK 98904048T DK 98904048 T DK98904048 T DK 98904048T DK 0956281 T3 DK0956281 T3 DK 0956281T3
Authority
DK
Denmark
Prior art keywords
ethoxycarbonylaminobenzene
fluorobenzylamino
amino
preparation
methods
Prior art date
Application number
DK98904048T
Other languages
English (en)
Inventor
Peter Meisel
Karl-Friedrich Landgraf
Juergen Schaefer
Alfred Olbrich
Bernhard Kutscher
Matthias Rischer
Wilfried Thiel
Original Assignee
Viatris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viatris Gmbh filed Critical Viatris Gmbh
Application granted granted Critical
Publication of DK0956281T3 publication Critical patent/DK0956281T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DK98904048T 1997-01-20 1998-01-09 Hidtil ukendte modifikationer af 2-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzen, såvel som fremgangsmåder til deres fremstilling DK0956281T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19701694A DE19701694A1 (de) 1997-01-20 1997-01-20 Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung
PCT/EP1998/000086 WO1998031663A1 (de) 1997-01-20 1998-01-09 Neue modifikationen des 2-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonyl-aminobenzen sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DK0956281T3 true DK0956281T3 (da) 2002-11-04

Family

ID=7817756

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98904048T DK0956281T3 (da) 1997-01-20 1998-01-09 Hidtil ukendte modifikationer af 2-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzen, såvel som fremgangsmåder til deres fremstilling

Country Status (31)

Country Link
US (2) US5914425A (da)
EP (1) EP0956281B1 (da)
JP (1) JP4138886B2 (da)
CN (1) CN1125812C (da)
AR (1) AR015349A1 (da)
AT (1) ATE222235T1 (da)
AU (1) AU730776B2 (da)
BG (1) BG63893B1 (da)
BR (1) BR9806784A (da)
CA (3) CA2632585C (da)
CZ (1) CZ301778B6 (da)
DE (2) DE19701694A1 (da)
DK (1) DK0956281T3 (da)
EG (1) EG21239A (da)
ES (1) ES2178152T3 (da)
HK (1) HK1024230A1 (da)
HU (1) HU227625B1 (da)
ID (1) ID22645A (da)
IL (1) IL130384A (da)
IS (1) IS2115B (da)
NO (2) NO311642B1 (da)
NZ (1) NZ336205A (da)
PL (1) PL195956B1 (da)
PT (1) PT956281E (da)
RU (1) RU2186765C2 (da)
SK (1) SK285303B6 (da)
TR (1) TR199901674T2 (da)
TW (1) TW531527B (da)
UA (1) UA63937C2 (da)
WO (1) WO1998031663A1 (da)
ZA (1) ZA98319B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI287984B (en) 2000-10-17 2007-10-11 Wyeth Corp Pharmaceutical composition for modulating bladder function
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
WO2002080898A2 (en) * 2001-04-04 2002-10-17 Wyeth Methods for treating hyperactive gastric motility
US7799832B2 (en) * 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8293911B2 (en) * 2006-08-23 2012-10-23 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
CN101578259A (zh) * 2006-11-28 2009-11-11 威朗国际制药公司 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US20100323015A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
KR20110052641A (ko) * 2008-07-18 2011-05-18 베일언트 파마슈티컬스 인터내셔널 변형 방출형 제형 및 이의 이용 방법
US20100323016A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
DE102009013612A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Retigabin-Tabletten, bevorzugt mit modifizierter Freisetzung
DE102009013611A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Festes Retigabin in nicht-kristalliner Form
DE102009013613A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Trockenverarbeitung von Retigabin
WO2011039369A2 (en) 2009-10-02 2011-04-07 Medichem S.A. Amorphous forms of a 2-amino-4-(4-fluorobenzylamino)phenylcarbamate derivative
CN102802615A (zh) 2010-01-20 2012-11-28 葛兰素集团有限公司 新瑞替加滨组合物
US20130131164A1 (en) * 2010-02-19 2013-05-23 Medichem, S.A. Stabilized phenylcarbamate derivative in solid state
CN202095728U (zh) * 2010-10-29 2012-01-04 假日集团控股有限公司 行李箱把手
CN102464233A (zh) * 2010-11-18 2012-05-23 江苏邦威机械制造有限公司 一种卧式差速缠丝机用应力发生装置
SG191309A1 (en) 2011-01-18 2013-07-31 Glaxo Group Ltd Process for the preparation of retigabine
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
WO2013008250A2 (en) * 2011-07-01 2013-01-17 Dr.Reddys Laboratories Limited. Crystalline form of retigabine and processes for mixture of retigabine crystalline modifications
WO2013011518A1 (en) 2011-07-21 2013-01-24 Arch Pharmalabs Limited Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof
CN102531966B (zh) * 2011-12-23 2013-07-24 山东创新药物研发有限公司 瑞替加滨的晶型d及其制备方法
US20140350285A1 (en) * 2012-01-30 2014-11-27 Symed Labs Limited Novel polymorphs of n-[2-amino-4-(4-fluorobenzylamino)-phenyl] carbamic acid ethyl ester and processes thereof
CN103373941B (zh) * 2012-04-11 2016-08-17 浙江九洲药物科技有限公司 瑞替加滨及其中间体的制备方法
WO2013179298A2 (en) * 2012-04-23 2013-12-05 Cadila Healthcare Limited A process for preparation of phenyl carbamate derivative and polymorphic forms thereof
WO2014023270A1 (en) 2012-08-09 2014-02-13 Zentiva, K.S. Salts or co-crystals of ethyl n-[2-amino-4-[(4-fluorophenyl)methylamino]-phenyl]carbamate
CN102964273B (zh) * 2012-12-06 2014-04-02 北京英科博雅科技有限公司 瑞替加滨的新晶型f及其制备方法
USD773819S1 (en) 2015-05-27 2016-12-13 Travelpro Products, Inc. Handle for luggage

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung

Also Published As

Publication number Publication date
IS2115B (is) 2006-06-15
IL130384A (en) 2003-02-12
JP4138886B2 (ja) 2008-08-27
BR9806784A (pt) 2000-05-02
HU227625B1 (en) 2011-09-28
NO2011017I2 (no) 2013-04-02
CZ301778B6 (cs) 2010-06-23
NO2011017I1 (no) 2011-09-26
BG103657A (en) 2000-02-29
ES2178152T3 (es) 2002-12-16
DE59805186D1 (de) 2002-09-19
IS5098A (is) 1999-06-29
CA2632585C (en) 2010-08-24
EP0956281B1 (de) 2002-08-14
BG63893B1 (bg) 2003-05-30
CA2632585A1 (en) 1998-07-23
EG21239A (en) 2001-03-31
WO1998031663A1 (de) 1998-07-23
PL195956B1 (pl) 2007-11-30
UA63937C2 (uk) 2004-02-16
AU730776B2 (en) 2001-03-15
ZA98319B (en) 1998-05-07
PT956281E (pt) 2002-12-31
ID22645A (id) 1999-12-02
SK285303B6 (sk) 2006-10-05
AU6208198A (en) 1998-08-07
CA2278201C (en) 2009-06-16
TR199901674T2 (da) 1999-10-21
RU2186765C2 (ru) 2002-08-10
EP0956281A1 (de) 1999-11-17
PL335647A1 (en) 2000-05-08
HUP0000944A2 (hu) 2000-09-28
IL130384A0 (en) 2000-06-01
NO993452D0 (no) 1999-07-13
NO311642B1 (no) 2001-12-27
CA2634811C (en) 2012-11-20
CA2278201A1 (en) 1998-07-23
SK95699A3 (en) 2000-03-13
NZ336205A (en) 2000-01-28
JP2001508077A (ja) 2001-06-19
AR015349A1 (es) 2001-05-02
HK1024230A1 (en) 2000-10-05
CZ250899A3 (cs) 1999-11-17
ATE222235T1 (de) 2002-08-15
NO993452L (no) 1999-07-13
US5914425A (en) 1999-06-22
CN1243506A (zh) 2000-02-02
CA2634811A1 (en) 1998-07-23
US6538151B1 (en) 2003-03-25
HUP0000944A3 (en) 2000-10-30
CN1125812C (zh) 2003-10-29
DE19701694A1 (de) 1998-07-23
TW531527B (en) 2003-05-11

Similar Documents

Publication Publication Date Title
DK0956281T3 (da) Hidtil ukendte modifikationer af 2-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzen, såvel som fremgangsmåder til deres fremstilling
DK1176195T3 (da) Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle
DK1038008T3 (da) Fremgangsmåde til fremstilling af EGIII-lignende enzymer
DK1296935T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1123284T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1032566T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1173431T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1032565T3 (da) Fremgangsmåde til fremstilling af derivater af taxoid-klassen
DK1105382T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1159274T3 (da) Fremgangsmåde til fremstilling af citalopram
DK0937055T3 (da) Fremgangsmåde til fremstilling af d,I-alfa-tocopherol
DK1309581T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1142990T3 (da) Fremgangsmåde til fremstilling af transglutaminase
DK0996642T3 (da) Fremgangsmåde til fremstilling af heparin
DK1028960T3 (da) Fremgangsmåde til fremstilling af thiazolidinedion
DK0966445T3 (da) Fremgangsmåder til fremstilling af mellemprodukter til pesticider
DK1170591T3 (da) Fremgangsmåde til identifikation af kombinationer af forbindelser som terapeutiske midler
DK1326836T3 (da) Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-methylpyridin
DK0970939T3 (da) Fremgangsmåde til fremstilling af methanol
DK1296970T3 (da) Fremgangsmåde til fremstilling af citalopram
DK0864564T3 (da) Særlig fremgangsmåde til fremstillingen af alfa-bromlactamderivater
DK0927766T3 (da) Enzymatisk fremgangsmåde til fremstilling af (S)-cyanhydriner
DK0973769T3 (da) Fremgangsmåde til fremstilling af eprosartan
DK0951561T3 (da) Enzymatiske fremgangsmåder til fremstilling af (S)-cyanhydriner
DK0970073T3 (da) Fremgangsmåde til fremstilling af eprosartan