PT956281E - Novas modificacoes do 2-amino-4-(4- fluorobenzilamino)-1-etoxicarbonil-aminobenzeno, bem como processos para a sua preparacao - Google Patents

Novas modificacoes do 2-amino-4-(4- fluorobenzilamino)-1-etoxicarbonil-aminobenzeno, bem como processos para a sua preparacao

Info

Publication number
PT956281E
PT956281E PT98904048T PT98904048T PT956281E PT 956281 E PT956281 E PT 956281E PT 98904048 T PT98904048 T PT 98904048T PT 98904048 T PT98904048 T PT 98904048T PT 956281 E PT956281 E PT 956281E
Authority
PT
Portugal
Prior art keywords
etoxicarbonyl
fluorobenzylamino
aminobenzene
amino
processes
Prior art date
Application number
PT98904048T
Other languages
English (en)
Inventor
Bernhard Kutscher
Karl-Friedrich Landgraf
Peter Meisel
Jurgen Schafer
Wilfried Thiel
Matthias Rischer
Alfred Olbrich
Original Assignee
Viatris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viatris Gmbh filed Critical Viatris Gmbh
Publication of PT956281E publication Critical patent/PT956281E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT98904048T 1997-01-20 1998-01-09 Novas modificacoes do 2-amino-4-(4- fluorobenzilamino)-1-etoxicarbonil-aminobenzeno, bem como processos para a sua preparacao PT956281E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19701694A DE19701694A1 (de) 1997-01-20 1997-01-20 Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
PT956281E true PT956281E (pt) 2002-12-31

Family

ID=7817756

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98904048T PT956281E (pt) 1997-01-20 1998-01-09 Novas modificacoes do 2-amino-4-(4- fluorobenzilamino)-1-etoxicarbonil-aminobenzeno, bem como processos para a sua preparacao

Country Status (31)

Country Link
US (2) US5914425A (pt)
EP (1) EP0956281B1 (pt)
JP (1) JP4138886B2 (pt)
CN (1) CN1125812C (pt)
AR (1) AR015349A1 (pt)
AT (1) ATE222235T1 (pt)
AU (1) AU730776B2 (pt)
BG (1) BG63893B1 (pt)
BR (1) BR9806784A (pt)
CA (3) CA2632585C (pt)
CZ (1) CZ301778B6 (pt)
DE (2) DE19701694A1 (pt)
DK (1) DK0956281T3 (pt)
EG (1) EG21239A (pt)
ES (1) ES2178152T3 (pt)
HK (1) HK1024230A1 (pt)
HU (1) HU227625B1 (pt)
ID (1) ID22645A (pt)
IL (1) IL130384A (pt)
IS (1) IS2115B (pt)
NO (2) NO311642B1 (pt)
NZ (1) NZ336205A (pt)
PL (1) PL195956B1 (pt)
PT (1) PT956281E (pt)
RU (1) RU2186765C2 (pt)
SK (1) SK285303B6 (pt)
TR (1) TR199901674T2 (pt)
TW (1) TW531527B (pt)
UA (1) UA63937C2 (pt)
WO (1) WO1998031663A1 (pt)
ZA (1) ZA98319B (pt)

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US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
AU2002338333A1 (en) * 2001-04-04 2002-10-21 Wyeth Methods for treating hyperactive gastric motility
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
BRPI0716715B1 (pt) * 2006-08-23 2021-07-06 Xenon Pharmaceuticals, Inc Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
KR20090083479A (ko) * 2006-11-28 2009-08-03 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US20100323016A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
EA201170230A1 (ru) * 2008-07-18 2011-08-30 Вэлиант Фармасьютикалс Интернешнл Препарат с модифицированной кинетикой высвобождения и способы его использования
US20100323015A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
DE102009013611A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Festes Retigabin in nicht-kristalliner Form
DE102009013613A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Trockenverarbeitung von Retigabin
DE102009013612A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Retigabin-Tabletten, bevorzugt mit modifizierter Freisetzung
WO2011039369A2 (en) 2009-10-02 2011-04-07 Medichem S.A. Amorphous forms of a 2-amino-4-(4-fluorobenzylamino)phenylcarbamate derivative
AU2011208745B2 (en) 2010-01-20 2013-11-14 Glaxo Group Limited Novel retigabine composition
US20130131164A1 (en) * 2010-02-19 2013-05-23 Medichem, S.A. Stabilized phenylcarbamate derivative in solid state
CN202095728U (zh) * 2010-10-29 2012-01-04 假日集团控股有限公司 行李箱把手
CN102464233A (zh) * 2010-11-18 2012-05-23 江苏邦威机械制造有限公司 一种卧式差速缠丝机用应力发生装置
SG191309A1 (en) 2011-01-18 2013-07-31 Glaxo Group Ltd Process for the preparation of retigabine
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
WO2013008250A2 (en) * 2011-07-01 2013-01-17 Dr.Reddys Laboratories Limited. Crystalline form of retigabine and processes for mixture of retigabine crystalline modifications
WO2013011518A1 (en) 2011-07-21 2013-01-24 Arch Pharmalabs Limited Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof
CN102531966B (zh) * 2011-12-23 2013-07-24 山东创新药物研发有限公司 瑞替加滨的晶型d及其制备方法
WO2013114379A1 (en) * 2012-01-30 2013-08-08 Symed Labs Limited Novel polymorphs of n-[2-amino-4-(4-fluorobenzylamino)-phenyl] carbamic acid ethyl ester and processes thereof
CN103373941B (zh) * 2012-04-11 2016-08-17 浙江九洲药物科技有限公司 瑞替加滨及其中间体的制备方法
WO2013179298A2 (en) * 2012-04-23 2013-12-05 Cadila Healthcare Limited A process for preparation of phenyl carbamate derivative and polymorphic forms thereof
WO2014023270A1 (en) 2012-08-09 2014-02-13 Zentiva, K.S. Salts or co-crystals of ethyl n-[2-amino-4-[(4-fluorophenyl)methylamino]-phenyl]carbamate
CN102964273B (zh) * 2012-12-06 2014-04-02 北京英科博雅科技有限公司 瑞替加滨的新晶型f及其制备方法
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DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung

Also Published As

Publication number Publication date
ZA98319B (en) 1998-05-07
PL335647A1 (en) 2000-05-08
NO993452D0 (no) 1999-07-13
ES2178152T3 (es) 2002-12-16
CA2634811C (en) 2012-11-20
ATE222235T1 (de) 2002-08-15
ID22645A (id) 1999-12-02
UA63937C2 (uk) 2004-02-16
IS5098A (is) 1999-06-29
BR9806784A (pt) 2000-05-02
DE19701694A1 (de) 1998-07-23
DK0956281T3 (da) 2002-11-04
CA2634811A1 (en) 1998-07-23
BG103657A (en) 2000-02-29
AR015349A1 (es) 2001-05-02
EP0956281A1 (de) 1999-11-17
SK95699A3 (en) 2000-03-13
HK1024230A1 (en) 2000-10-05
CN1125812C (zh) 2003-10-29
NO2011017I1 (no) 2011-09-26
EG21239A (en) 2001-03-31
NO311642B1 (no) 2001-12-27
BG63893B1 (bg) 2003-05-30
DE59805186D1 (de) 2002-09-19
CA2632585C (en) 2010-08-24
EP0956281B1 (de) 2002-08-14
IS2115B (is) 2006-06-15
CN1243506A (zh) 2000-02-02
PL195956B1 (pl) 2007-11-30
IL130384A0 (en) 2000-06-01
NO993452L (no) 1999-07-13
SK285303B6 (sk) 2006-10-05
IL130384A (en) 2003-02-12
CZ301778B6 (cs) 2010-06-23
TR199901674T2 (pt) 1999-10-21
WO1998031663A1 (de) 1998-07-23
HUP0000944A3 (en) 2000-10-30
HUP0000944A2 (hu) 2000-09-28
TW531527B (en) 2003-05-11
JP4138886B2 (ja) 2008-08-27
US6538151B1 (en) 2003-03-25
CZ250899A3 (cs) 1999-11-17
RU2186765C2 (ru) 2002-08-10
US5914425A (en) 1999-06-22
NZ336205A (en) 2000-01-28
HU227625B1 (en) 2011-09-28
AU6208198A (en) 1998-08-07
CA2278201C (en) 2009-06-16
CA2278201A1 (en) 1998-07-23
NO2011017I2 (no) 2013-04-02
CA2632585A1 (en) 1998-07-23
AU730776B2 (en) 2001-03-15
JP2001508077A (ja) 2001-06-19

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