TR199802140T2 - Karbapenem antibakteriyel bilesikleri, bu tür bilesikleri içeren bilesimler ve isleme yöntemleri. - Google Patents

Karbapenem antibakteriyel bilesikleri, bu tür bilesikleri içeren bilesimler ve isleme yöntemleri.

Info

Publication number
TR199802140T2
TR199802140T2 TR1998/02140T TR9802140T TR199802140T2 TR 199802140 T2 TR199802140 T2 TR 199802140T2 TR 1998/02140 T TR1998/02140 T TR 1998/02140T TR 9802140 T TR9802140 T TR 9802140T TR 199802140 T2 TR199802140 T2 TR 199802140T2
Authority
TR
Turkey
Prior art keywords
compounds
compositions containing
processing methods
carbapenem antibacterial
carbapenem
Prior art date
Application number
TR1998/02140T
Other languages
English (en)
Inventor
R. Wilkening Robert
W. Ratcliffe Ronald
A. Blizzard Timothy
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609741.5A external-priority patent/GB9609741D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of TR199802140T2 publication Critical patent/TR199802140T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Mevcut bulus, karbapenem çekirdeginin, bir CH2 grubu ile bagli olan bir naftasültam ile, pozisyon 2'de yer degistirdigi karbapenem antibakteriyellerle ilgilidir. Naftasültam daha sonra, en az bir katyonik grup içeren çesitli ikame gruplariyla yer degistirir. Bilesikler, formül (I) ile sunulurlar.Farmakolojik bilesikler ve kullanim yöntemleri de dahildir.
TR1998/02140T 1996-04-24 1997-04-21 Karbapenem antibakteriyel bilesikleri, bu tür bilesikleri içeren bilesimler ve isleme yöntemleri. TR199802140T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1618496P 1996-04-24 1996-04-24
GBGB9609741.5A GB9609741D0 (en) 1996-05-10 1996-05-10 Carbapenem antibacterial compounds compositions containing such componds and methods of treatment

Publications (1)

Publication Number Publication Date
TR199802140T2 true TR199802140T2 (tr) 1999-01-18

Family

ID=26309297

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/02140T TR199802140T2 (tr) 1996-04-24 1997-04-21 Karbapenem antibakteriyel bilesikleri, bu tür bilesikleri içeren bilesimler ve isleme yöntemleri.

Country Status (31)

Country Link
EP (1) EP0906313B1 (tr)
JP (1) JP3176068B2 (tr)
KR (1) KR20000010599A (tr)
CN (1) CN1074767C (tr)
AR (1) AR006810A1 (tr)
AT (1) ATE260915T1 (tr)
AU (1) AU707459B2 (tr)
BG (1) BG102949A (tr)
BR (1) BR9708864A (tr)
CA (1) CA2252402C (tr)
CO (1) CO4990968A1 (tr)
CZ (1) CZ340798A3 (tr)
DE (1) DE69727931T2 (tr)
EA (1) EA001296B1 (tr)
EE (1) EE03689B1 (tr)
ES (1) ES2216142T3 (tr)
HK (1) HK1021186A1 (tr)
HR (1) HRP970213A2 (tr)
HU (1) HUP9901778A3 (tr)
ID (1) ID16662A (tr)
IL (1) IL126480A0 (tr)
IS (1) IS4861A (tr)
NO (1) NO984949L (tr)
NZ (1) NZ332183A (tr)
PE (1) PE64298A1 (tr)
PL (1) PL186881B1 (tr)
SK (1) SK283550B6 (tr)
TR (1) TR199802140T2 (tr)
TW (1) TW539677B (tr)
WO (1) WO1997040048A1 (tr)
YU (1) YU46298A (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7163522B1 (en) 1994-03-02 2007-01-16 Scimed Life Systems, Inc. Block copolymer elastomer catheter balloons
US6406457B1 (en) 1994-03-02 2002-06-18 Scimed Life Systems, Inc. Block copolymer elastomer catheter balloons
AU728091B2 (en) * 1997-05-13 2001-01-04 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
US5908936A (en) * 1997-05-13 1999-06-01 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
EP1027352A4 (en) * 1997-10-23 2001-09-19 Merck & Co Inc ANTIBACTERIAL CARBAPENEM COMPOUNDS, COMPOSITIONS AND TREATMENT METHODS
US6140318A (en) 1997-10-23 2000-10-31 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
WO1999020628A1 (en) * 1997-10-23 1999-04-29 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6271222B1 (en) * 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
ATE263766T1 (de) * 1998-06-17 2004-04-15 Merck & Co Inc Verfahren zur synthese von carbapenem- zwischenprodukten
CA2335571A1 (en) * 1998-06-25 1999-12-29 Merck & Co. Inc. (heterocyclic) methyl substituted carbapenem antibacterials
AU4710999A (en) * 1998-06-25 2000-01-10 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US7672747B2 (en) 2000-03-30 2010-03-02 Lam Research Corporation Recipe-and-component control module and methods thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429341A3 (en) * 1989-11-20 1991-11-13 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and pharmaceuticals containing them
FR2661177A1 (fr) * 1990-04-23 1991-10-25 Rhone Poulenc Sante Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant.
US5451579A (en) * 1994-02-15 1995-09-19 Merck & Co., Inc. 1-β-methyl-carbapenem, compositions containing same and methods of use

Also Published As

Publication number Publication date
JP3176068B2 (ja) 2001-06-11
EE03689B1 (et) 2002-04-15
EA001296B1 (ru) 2000-12-25
HK1021186A1 (en) 2000-06-02
HUP9901778A3 (en) 2000-06-28
NO984949L (no) 1998-12-21
IL126480A0 (en) 1999-08-17
SK283550B6 (sk) 2003-09-11
ATE260915T1 (de) 2004-03-15
CA2252402A1 (en) 1997-10-30
CO4990968A1 (es) 2000-12-26
NO984949D0 (no) 1998-10-23
PL329376A1 (en) 1999-03-29
HUP9901778A2 (hu) 1999-09-28
EP0906313B1 (en) 2004-03-03
EA199800949A1 (ru) 1999-04-29
NZ332183A (en) 2000-05-26
BR9708864A (pt) 1999-08-03
CZ340798A3 (cs) 1999-03-17
DE69727931D1 (de) 2004-04-08
TW539677B (en) 2003-07-01
CA2252402C (en) 2002-12-24
EP0906313A1 (en) 1999-04-07
DE69727931T2 (de) 2005-04-14
YU46298A (sh) 2000-03-21
ID16662A (id) 1997-10-30
KR20000010599A (ko) 2000-02-15
AU2462997A (en) 1997-11-12
ES2216142T3 (es) 2004-10-16
CN1074767C (zh) 2001-11-14
WO1997040048A1 (en) 1997-10-30
PL186881B1 (pl) 2004-03-31
JPH11508279A (ja) 1999-07-21
IS4861A (is) 1998-10-06
AU707459B2 (en) 1999-07-08
PE64298A1 (es) 1998-10-30
BG102949A (bg) 1999-10-29
HRP970213A2 (en) 1998-06-30
EE9800355A (et) 1999-04-15
AR006810A1 (es) 1999-09-29
SK145498A3 (en) 1999-10-08
CN1222912A (zh) 1999-07-14

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