DE69727931D1 - Antibakterielle carbapenem-verbindungen, sie enthaltende zusammensetzungen undbehandlungsverfahren - Google Patents

Antibakterielle carbapenem-verbindungen, sie enthaltende zusammensetzungen undbehandlungsverfahren

Info

Publication number
DE69727931D1
DE69727931D1 DE69727931T DE69727931T DE69727931D1 DE 69727931 D1 DE69727931 D1 DE 69727931D1 DE 69727931 T DE69727931 T DE 69727931T DE 69727931 T DE69727931 T DE 69727931T DE 69727931 D1 DE69727931 D1 DE 69727931D1
Authority
DE
Germany
Prior art keywords
compositions containing
treatment methods
carbapenem compounds
antibacterial
antibacterial carbapenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69727931T
Other languages
English (en)
Other versions
DE69727931T2 (de
Inventor
R Wilkening
W Ratcliffe
A Blizzard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609741.5A external-priority patent/GB9609741D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69727931D1 publication Critical patent/DE69727931D1/de
Publication of DE69727931T2 publication Critical patent/DE69727931T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69727931T 1996-04-24 1997-04-21 Antibakterielle carbapenem-verbindungen, sie enthaltende zusammensetzungen undbehandlungsverfahren Expired - Lifetime DE69727931T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1618496P 1996-04-24 1996-04-24
US16184P 1996-04-24
GBGB9609741.5A GB9609741D0 (en) 1996-05-10 1996-05-10 Carbapenem antibacterial compounds compositions containing such componds and methods of treatment
GB9609741 1996-05-10
PCT/US1997/006626 WO1997040048A1 (en) 1996-04-24 1997-04-21 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Publications (2)

Publication Number Publication Date
DE69727931D1 true DE69727931D1 (de) 2004-04-08
DE69727931T2 DE69727931T2 (de) 2005-04-14

Family

ID=26309297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69727931T Expired - Lifetime DE69727931T2 (de) 1996-04-24 1997-04-21 Antibakterielle carbapenem-verbindungen, sie enthaltende zusammensetzungen undbehandlungsverfahren

Country Status (31)

Country Link
EP (1) EP0906313B1 (de)
JP (1) JP3176068B2 (de)
KR (1) KR20000010599A (de)
CN (1) CN1074767C (de)
AR (1) AR006810A1 (de)
AT (1) ATE260915T1 (de)
AU (1) AU707459B2 (de)
BG (1) BG102949A (de)
BR (1) BR9708864A (de)
CA (1) CA2252402C (de)
CO (1) CO4990968A1 (de)
CZ (1) CZ340798A3 (de)
DE (1) DE69727931T2 (de)
EA (1) EA001296B1 (de)
EE (1) EE03689B1 (de)
ES (1) ES2216142T3 (de)
HK (1) HK1021186A1 (de)
HR (1) HRP970213A2 (de)
HU (1) HUP9901778A3 (de)
ID (1) ID16662A (de)
IL (1) IL126480A0 (de)
IS (1) IS4861A (de)
NO (1) NO984949L (de)
NZ (1) NZ332183A (de)
PE (1) PE64298A1 (de)
PL (1) PL186881B1 (de)
SK (1) SK283550B6 (de)
TR (1) TR199802140T2 (de)
TW (1) TW539677B (de)
WO (1) WO1997040048A1 (de)
YU (1) YU46298A (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406457B1 (en) 1994-03-02 2002-06-18 Scimed Life Systems, Inc. Block copolymer elastomer catheter balloons
US7163522B1 (en) 1994-03-02 2007-01-16 Scimed Life Systems, Inc. Block copolymer elastomer catheter balloons
AU728091B2 (en) * 1997-05-13 2001-01-04 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
US5908936A (en) * 1997-05-13 1999-06-01 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
JP2001520229A (ja) * 1997-10-23 2001-10-30 メルク エンド カムパニー インコーポレーテッド カルバペネム系抗菌化合物、該化合物を含有する組成物および治療方法
US6140318A (en) * 1997-10-23 2000-10-31 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
AU739799B2 (en) * 1997-10-23 2001-10-18 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions and methods of treatment
US6271222B1 (en) * 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
US6489471B1 (en) * 1998-06-17 2002-12-03 Merck & Co., Inc. Process for the synthesis of carbapenem intermediates, and compounds produced
CA2335497A1 (en) * 1998-06-25 1999-12-29 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
EP1089999A4 (de) * 1998-06-25 2002-12-04 Merck & Co Inc Antibakterielle, heterozyklomethyl-substituierte carbapenem-verbindungen
US7672747B2 (en) 2000-03-30 2010-03-02 Lam Research Corporation Recipe-and-component control module and methods thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429341A3 (en) * 1989-11-20 1991-11-13 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and pharmaceuticals containing them
FR2661177A1 (fr) * 1990-04-23 1991-10-25 Rhone Poulenc Sante Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant.
US5451579A (en) * 1994-02-15 1995-09-19 Merck & Co., Inc. 1-β-methyl-carbapenem, compositions containing same and methods of use

Also Published As

Publication number Publication date
EP0906313B1 (de) 2004-03-03
SK283550B6 (sk) 2003-09-11
NO984949D0 (no) 1998-10-23
CN1074767C (zh) 2001-11-14
TR199802140T2 (xx) 1999-01-18
WO1997040048A1 (en) 1997-10-30
NZ332183A (en) 2000-05-26
EP0906313A1 (de) 1999-04-07
SK145498A3 (en) 1999-10-08
HK1021186A1 (en) 2000-06-02
CO4990968A1 (es) 2000-12-26
DE69727931T2 (de) 2005-04-14
EA001296B1 (ru) 2000-12-25
NO984949L (no) 1998-12-21
CA2252402C (en) 2002-12-24
YU46298A (sh) 2000-03-21
IL126480A0 (en) 1999-08-17
KR20000010599A (ko) 2000-02-15
CA2252402A1 (en) 1997-10-30
EE03689B1 (et) 2002-04-15
BG102949A (bg) 1999-10-29
AU2462997A (en) 1997-11-12
HUP9901778A3 (en) 2000-06-28
EA199800949A1 (ru) 1999-04-29
ID16662A (id) 1997-10-30
HRP970213A2 (en) 1998-06-30
ES2216142T3 (es) 2004-10-16
CN1222912A (zh) 1999-07-14
ATE260915T1 (de) 2004-03-15
JPH11508279A (ja) 1999-07-21
EE9800355A (et) 1999-04-15
JP3176068B2 (ja) 2001-06-11
BR9708864A (pt) 1999-08-03
CZ340798A3 (cs) 1999-03-17
HUP9901778A2 (hu) 1999-09-28
PL329376A1 (en) 1999-03-29
TW539677B (en) 2003-07-01
IS4861A (is) 1998-10-06
PL186881B1 (pl) 2004-03-31
AR006810A1 (es) 1999-09-29
PE64298A1 (es) 1998-10-30
AU707459B2 (en) 1999-07-08

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